ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_25100
The gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25101
The gene COL1A1 (collagen type I alpha 1 chain), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Infantile cortical hyperostosis
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25102
Here is a mutation in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Osteogenesis imperfecta with normal sclerae, dominant form
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25103
A variant found in Chromosome 17 affects COL1A1 (collagen type I alpha 1 chain). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Ehlers-Danlos syndrome, arthrochalasia type
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25104
Consider a variant on Chromosome 17 in gene COL1A1 (collagen type I alpha 1 chain). Determine its clinical classification and disease relevance.
Pathogenic; Osteogenesis imperfecta type I
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25105
This gene mutation involves COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it associated with any clinical condition, or is it benign?
Pathogenic; Osteogenesis imperfecta, perinatal lethal
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
CATGGATCCTCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCTGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAG
Task1_train_25106
A variant found in Chromosome 17 affects COL1A1 (collagen type I alpha 1 chain). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Osteogenesis imperfecta type I
TCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGAT
TCACTTAATACTCACAGCAGCACCTTTAGGTCCAGGGAATCCCATCACACCAGCCTGACCACGGGCACCAGGTGGGCCTGGGGGTCCGGGGCGACCATCTTGACCGGCGGGACCCTAAGGATGGGAGGCACGAAAGCAGCAGTGAGGACAGCAGGGAGGCAGACAGGACAATGGCAGGGGGTTCAGGGGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACTCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGAT
Task1_train_25107
Consider this mutation in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Infantile cortical hyperostosis
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25108
Here’s a variant in COL1A1 (collagen type I alpha 1 chain) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Ehlers-Danlos syndrome, arthrochalasia type
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25109
This mutation is located in gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Osteogenesis imperfecta with normal sclerae, dominant form
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25110
This variant affects the gene COL1A1 (collagen type I alpha 1 chain) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Postmenopausal osteoporosis
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25111
Gene COL1A1 (collagen type I alpha 1 chain), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Osteogenesis imperfecta type I
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25112
This mutation is located in gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Osteogenesis imperfecta, perinatal lethal
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25113
This variant lies on Chromosome 17 and affects the gene COL1A1 (collagen type I alpha 1 chain). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Osteogenesis imperfecta type III
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25114
Given this context: Chromosome 17, gene COL1A1 (collagen type I alpha 1 chain) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; COL1A1-related disorder
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25115
Mutation context: Chromosome 17, Gene COL1A1 (collagen type I alpha 1 chain). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Osteogenesis imperfecta with normal sclerae, dominant form
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25116
With a mutation on Chromosome 17 in gene COL1A1 (collagen type I alpha 1 chain), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Osteogenesis imperfecta type I
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25117
The variant affects gene COL1A1 (collagen type I alpha 1 chain), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Osteogenesis imperfecta
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
GGGAGTGATACTTACAGGGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCTGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATA
Task1_train_25118
Gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Osteogenesis imperfecta type I
GGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGG
GGGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCATCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGG
Task1_train_25119
A variant has been detected on Chromosome 17 in COL1A1 (collagen type I alpha 1 chain). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Osteogenesis imperfecta type I
GGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGG
GGGGCCAGTTTTGCCATCAGGACCAGGGCTGCCAGGGCTTCCAGTCAGACCCTAGGGAGGCAGAGAGGTATGAGTGGGACTTGGGGAGAAGCATGATGGAGGTGGGGGAGGACTCCAGAGGGCAGACCCTTGGGCCTGATCCAGAACGCCTCATCCCAGACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACGATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGG
Task1_train_25120
This genomic variant is located on Chromosome 17, within the COL1A1 (collagen type I alpha 1 chain) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Osteogenesis imperfecta type I
ACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGA
ACCCTACACGGGATGGTCAGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACGTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGA
Task1_train_25121
A mutation found in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Osteogenesis imperfecta type I
AGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTG
AGGGCCTGGCCAAGCCAGGCTGAAAGCCTGGGGCCTCACCTTGGCACCAGGCAGACCAGCTTCACCGGGACGACCAGCTTCACCAGGAGATCCTTTGGGGCCAGCAGGGCCAGGAGAACCACGTTCACCAGCGGGACCCTGGTTGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCTACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTG
Task1_train_25122
A variant found in Chromosome 17 affects COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Osteogenesis imperfecta type I
TGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAA
TGGGGGAAGTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCTATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAA
Task1_train_25123
A variant affecting Chromosome 17, within the gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), has been observed. Determine if it's benign or associated with disease.
Pathogenic; not provided
GTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAG
GTCACAGGAACAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCATCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAG
Task1_train_25124
A genetic alteration is present in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; not provided
CAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGA
CAGTTAGGGTCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCGAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGA
Task1_train_25125
A change on Chromosome 17 affects gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Osteogenesis imperfecta type I
TCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAG
TCTCAAGTTTGTGGCTCTTTGCCACGGGCCAAAAGAGGAAGAAGATGCCCAGGGAGCGGCAGGGTCAGCCCCCCGGCCGCAAGGAGAGGTTACCTTGGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACTCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAG
Task1_train_25126
A genomic change on Chromosome 17 affects COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Osteogenesis imperfecta type I
GGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAA
GGGACCAGCAACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGAGCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAA
Task1_train_25127
A genetic alteration is present in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Osteogenesis imperfecta type I
ACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATC
ACACCATCTGCGCCAGGGAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACTAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATC
Task1_train_25128
This alteration occurs within gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) located on Chromosome 17. Is it associated with a disease or is it a benign variant?
Pathogenic; Osteogenesis imperfecta, perinatal lethal
GAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGT
GAAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCATCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGT
Task1_train_25129
Given this variant in gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Osteogenesis imperfecta type I
AAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTC
AAACCACGGCTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACAATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTC
Task1_train_25130
This is a variant in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), located on Chromosome 17. Is this mutation a likely cause of disease or not?
Pathogenic; Infantile cortical hyperostosis
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACAACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
Task1_train_25131
Given a variant located on Chromosome 17 and affecting COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Osteogenesis imperfecta type I
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACAACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
Task1_train_25132
A genetic alteration is present in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Osteogenesis imperfecta type I
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
CTACCAGGTCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACTACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACA
Task1_train_25133
A variant on Chromosome 17 in gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Osteogenesis imperfecta type I
TCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACT
TCCACCCTGCAGGAGGAGAGGAGGCCAGTGAACTCCGCGACACACAGGCACCAGCCAGGCAATGAGGGTGGAGCGGGAGGGGGCGGGCAGGGACACTTACACGCTCGCCAGGGGGTCCGGGCAGGCCAGTGGGTCCGGGTTCACCTCGAGCTCCTCGCTTTCCTTCCTCTCCAGCAGGGCCAGGGGGTCCTTGAACACCAACAGGGCCCTGGAGAGGGCCGAGAGGAGGAGGCGGCCTGTGGTGAGGGGCCATCCTGTGCCAGCCTCAGAGCCGGCTGAGGCTGGGCCTCCAGTGTCAGGGGTTCCTGGGGGTGTGGCAGGGACTCCCCCAGAAGACTAGGGGCTCCTCTTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAATCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACT
Task1_train_25134
The variant affects gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Osteogenesis imperfecta type I
TTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAA
TTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCGCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAA
Task1_train_25135
The gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Osteogenesis imperfecta type I
TTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAA
TTCCTTTCTGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCTCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAA
Task1_train_25136
This genomic variant is located on Chromosome 17, within the COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Osteogenesis imperfecta type I
TGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATG
TGGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTTCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATG
Task1_train_25137
Here is a variant affecting COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Osteogenesis imperfecta
GGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGT
GGATTTCCCTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCTAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGT
Task1_train_25138
Here is a variant affecting COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Osteogenesis imperfecta type I
CTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACT
CTCAGGGGGCTCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGACAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACT
Task1_train_25139
Assess the clinical impact of this variant on gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Osteogenesis imperfecta type I
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCGGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25140
The gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; COL1A1-related disorder
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25141
This alteration in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Osteogenesis imperfecta
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25142
The gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Osteogenesis imperfecta type I
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25143
Located on Chromosome 17, this mutation impacts COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Osteoporosis
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25144
Consider this mutation in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Osteogenesis imperfecta with normal sclerae, dominant form
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25145
Here is a mutation in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Osteogenesis imperfecta type III
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25146
A variant has been detected on Chromosome 17 in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Osteogenesis imperfecta type I
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25147
This mutation is located in gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Osteogenesis imperfecta, perinatal lethal
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25148
This variant lies on Chromosome 17 and affects the gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Infantile cortical hyperostosis
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25149
This variant affects the gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Ehlers-Danlos syndrome, arthrochalasia type
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25150
A variant was discovered in gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901), Chromosome 17. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25151
A change on Chromosome 17 affects gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
TCCTAGGGCAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCTGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTA
Task1_train_25152
This variant affects the gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Osteogenesis imperfecta type III
CAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAG
CAGGGTGGGCTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATTCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAG
Task1_train_25153
A change on Chromosome 17 affects gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Osteogenesis imperfecta type I
CTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTA
CTGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCATCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTA
Task1_train_25154
Given this variant in gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; not provided
TGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAG
TGGGCTGCAAGAAGGATGGCGGGGAGACTTACAGGCTCTCCCTTAGCACCAGTGTCTCCTTTGCTGCCAGGAGCACCAGGTTCACCCTGCAAGGGGGGAGAAGAGGATGAGCTGAGAGTCGGGGGCGCTCAGTTGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACACTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAG
Task1_train_25155
Consider this mutation in COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; not provided
TGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGG
TGGCCTGCGTCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCTCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGG
Task1_train_25156
This alteration occurs within gene COL1A1, LOC126862586 (collagen type I alpha 1 chain| CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48273702-48274901) located on Chromosome 17. Is it associated with a disease or is it a benign variant?
Pathogenic; Osteogenesis imperfecta type I
TCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGG
TCTTCCTGCTCCCCAGATGAGAGCCGCACTGGAGCCAGTGCATGGGGTGGGCAGAAGGGAGAGTTTGGTACTCACGCTGTTACCCTTGGGACCAGGAGGGCCGCCGGGGCCCTGGGGTCCAGAGGGGCCTCGGGCACCAGGGAAGCCAGGAGCACCAGCAATACCAGGAGCACCCTGTGGGAGGCAGACAGCCAGGGCGTGAGCCTAGGAGCAGAGGGAAAGGGGCAGGCAGGCTGCAGGCGGCAGGAGTGGGACTGAAGCCTGGCAGGATACTTACATTGGCACCTTTAGCACCAGGCTGTCCATCAGCACCAGGGTTTCCCTGTGGCACAGAGAAAGGAGTGTCAGCAACAGGCAAGGACTCTGAGGTTAGAAAGTGGCAAAGGGGACACTGAGTCGGGGACACTTACAGCAGGGCCAGCAGCACCAGCAGGGCCAGGGGGGCCAGGCTCACCACGCACACCCTGGGGACCTTCAGAGCCTCGGGGCCCTTGGGGACCAGCTTCACCCTGAATCAGAAGAAAGGACATATCAGAAGCCACCCTGGGAAACCCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCAACAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGG
Task1_train_25157
With a mutation on Chromosome 17 in gene COL1A1 (collagen type I alpha 1 chain), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Osteogenesis imperfecta type I
CCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCC
CCAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGAGCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCC
Task1_train_25158
A sequence alteration has been identified in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it disease-inducing or harmless?
Pathogenic; Osteogenesis imperfecta type I
CAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCG
CAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACATGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCG
Task1_train_25159
The gene COL1A1 (collagen type I alpha 1 chain), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Osteogenesis imperfecta type I
CAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCG
CAACCTTGCCTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACTTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCG
Task1_train_25160
A genomic change on Chromosome 17 affects COL1A1 (collagen type I alpha 1 chain). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Osteogenesis imperfecta type I
CTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTC
CTCTCGGGATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACATCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTC
Task1_train_25161
Here’s a variant in COL1A1 (collagen type I alpha 1 chain) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Osteogenesis imperfecta type I
ATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTC
ATGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGAACCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTC
Task1_train_25162
The gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Osteogenesis imperfecta type I
TGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCG
TGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACACATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCG
Task1_train_25163
Given this variant in gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Osteogenesis imperfecta type I
TGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCG
TGGCAGGAGGAAGGGGAGACAGGGACAGGAGAGCAATGATCAGGACTCTAAGATCAGAGACGGAGAACCCAGGACAAAGGTGTTAGTGAACGGGCTGCTCTCTTGCCACTCTGGGTCCCTTTGGTTTGGGGAACAGGGAGACATGAACCCCTTGGCCCATGAGGGTCATGCTTAGAGGAGAGTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACGCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCG
Task1_train_25164
Gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Osteogenesis imperfecta type I
GTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCA
GTGGGGGGTCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCTAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCA
Task1_train_25165
This alteration in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Osteogenesis imperfecta type I
TCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCC
TCTCACCTTAGCACCAACAGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGTCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCC
Task1_train_25166
Mutation context: Chromosome 17, Gene COL1A1 (collagen type I alpha 1 chain). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Osteogenesis imperfecta type I
AGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACA
AGCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGAACTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACA
Task1_train_25167
Located on Chromosome 17, this mutation impacts COL1A1 (collagen type I alpha 1 chain). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Osteogenesis imperfecta type I
GCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACAC
GCACCAGGGAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACTTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACAC
Task1_train_25168
This sequence change occurs on Chromosome 17, altering COL1A1 (collagen type I alpha 1 chain). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Ehlers-Danlos syndrome, arthrochalasia type
GAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTT
GAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGACTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTT
Task1_train_25169
Here is a mutation in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Osteogenesis imperfecta type I
GAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTT
GAAGCCAGGAGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGACTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTT
Task1_train_25170
An alteration has been detected in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Osteogenesis imperfecta type I
AGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCC
AGGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGAGCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCC
Task1_train_25171
A mutation in COL1A1 (collagen type I alpha 1 chain), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; not provided
GGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCC
GGACCAGCGGGGCCGGTGGGACCCTGTGAATGAAATGGAGATGTCAGCGAGAAGGAAGAGATGGCAGCTGCAAGTCACACCCTGGGACAGAGGAAGTCCTGGGGTTCAGACCAACATAACCTGCTCCCATTGTCAGCCCCAAGAGCAGATACTGAGACCCCTCCCCACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACACTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCC
Task1_train_25172
This alteration in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
ACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAG
ACTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCATCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAG
Task1_train_25173
This variant lies on Chromosome 17 and affects the gene COL1A1 (collagen type I alpha 1 chain). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Osteogenesis imperfecta
CTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGC
CTCCCAGGCCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACGAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGC
Task1_train_25174
A mutation in COL1A1 (collagen type I alpha 1 chain), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Osteogenesis imperfecta type I
CCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGC
CCCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGTCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGC
Task1_train_25175
This genomic variant is located on Chromosome 17, within the COL1A1 (collagen type I alpha 1 chain) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Osteogenesis imperfecta type I
CCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCG
CCTGAGGCCTACAGGCCACACTCACAGGGGGCCCGGCAGCACCAGTAGCACCATCATTTCCACGAGCACCCTGCAGGAGAGAGGGGAAGCCCCGTTAAGTCCACTGAGCACTGGCCAGTCCCTAGAGTTCCTGGGGAGCCCCTTCCAGAGCTCAGGGATCCCCCAAGGGGCCAGGAGTACTTACAGCAGGGCCAGGGGCTCCAGGGCGACCTCTCTCACCAGGCAGGCCACGGGGGCCCTGACAACCAAACCAAGAGAAGTCAGATGAGATGGGAGACAGCCTTGTTCCCCCAGGCCTCCATCTTGCCCCTGCCTCCTGCCCCATCCCTGCCCTCTGGAACTGGGCACACTCACCATCTGACCAGGAGCTCCATTTTCACCAGGGCTGCCAGGCTCACCCTGTAGATCAGAGAATAATGAGTGAGAAATTCATTCATGGTGGGACTCTGGGGATGTGGAGGACCATGATGTTCAGACAGCCTCTTACCTTAGGACCAGCAGGACCAGCATCTCCCTTGGCACCATCCAAACCACTGAAACCCTAAAGCAGGAAAGAGGTAGAAGGTAAGAACCTGTGGAGGGGGTGGAACAGCCTTGACATCCACCTAGATCTGAGAAAGAGCCTTGGGAGGTCATCACCGCCATCCCTTTGTTTCTGAGCTAGACTAAACCCCAACTGGCTCTAGATCTCACCCAATCGTTTAATCGGGACTGCTTTCCCATGGAGGGAGGTGCTTTTGGATGTCCACTCTCTGTCCCTTGGGACTTCTGTAGCTGCCACCCACCATGATGCAACTCAGTATCTTTTGGGGAAGAGGTTGGGACTGGATGGGGGTATGCTAGGGACTTGGGGAGCTTAAATGACTCAAAGGTGACTCACTCTGTGTCCCTTCATTCCAGGGAGGCCAGCTGTTCCGGGCAATCCTCGAGCACCCTGGAGAGAGATGAAGAAGACAAGGAAGGGCCATTAGAACACATCACTGTGGACCCAGCTCCTAAATGAAGCCCAAGTGCAGTGAAGCCCAGGTTCAGCCACAGCCCCCTGCTCACCTGAGGCCCAGGAGGCCCACGCTCACCAGGACGACCAGGTTTTCCAGCTTCCCCCTGAGAGGGAGAGAAAAGACCATCATGCCTCTGCCTCCCCACCACCGCCTAGGGGCTGGAAAAGTGGAGAAGGTCTCAGTCTTCTTTGGATTGTTGCAGGTCAGGTTTGGGGGCCCAGAATCTTATCTTTGAATCTAGAGCTCAGTTTAAATCTACAGTGAAACCTTCGTTTGGTGAAATCTGAGTGCCTCTAAAGGAATTTCTGTCTACTTCTGTCACCAGCATTTTAATTTCACCATCTGCGCACCAATTTCCCCAAAGGGATGGGGTTGGGGATTGCTCTAAGGTGGCTGGGGTGAGGAGAACAGTCACTTTGTTGGGGACATGGAATCATCTCACTAAGCGAAAAGATCATTGTTCCAGGGCAGTCCGTGCATCAGAGAGGACTTGCCCTCCTTCCTCTGAGTATCGTTCCCAAATGTGGTGGAGTGGAAATTGCAGGACCCAACCCATGGAGGCCATGGGGTCAGATGGTATCTTCTTGCTGGGGATACTTACATCATCTCCATTCTTTCCAGGGGGACCTGGGGGACCTCGGGGACCCATGGGACCCTAGAAAAGATAGAAGAGGTGGTTAGAATATGGATAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCTAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCG
Task1_train_25176
This variant impacts the gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; Osteogenesis imperfecta type I
TAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACC
TAAGAAAAAAAGAAGGGGAAGGCTGGGATTGAAGGGAAGAGGTAAGGAAGACCCCAGGCCTGGGAGTTCTTCTATAGGAGAGTCTGTGTGTTTGTAGAAGGAGTATGAATCTGTATAGAGAGTGCTTACTGAAGCTCCAGGCTCGCCAGGCTCACCAGGGGGACCTTGGAAGCCTTGGGGACCCTTGAGAAGAAGGAAAAAGATGGGTTAGAAGACAAGTCCCTGTCAACCTTCTCCAATCTTACCAAGAGATCTCTGAGCATCTCTCCTGCCCTCATCCCAGTCTTCCCTCCAAAAGACCAAAGCCCAAGGAGGCATATGAAGACGTCCTGGATACTCACAGGTGCACCAGGGGGGCCAGGGAGACCACGAGGACCAGAGGGACCCTATAGAGGGAGAAGAAAGGGGGGTCATGGTGATCCCTCTGTAGGAAAGCATGTGGATGTAGTCATTCATGCCTGTTGGGACCACCCAGTCGTCCTGCATCCTTTCTGGACTCTGAGGTCCCAAAGGTGATCTGGACCTCCCAAGCTGTCTATACCAGCCGCCTATGCCCACCTCCTCTGGATACCCATTCTCTCTTCTGTCATCCATGCTCCCCCTGCTGGCTCACCATGGGGCCAGGCACGGAAATTCCTCCGGTTGATTTCTCATCATAGCCATAAGACAGCTGGGGAGCAAAGTTCTAGAACAAACAAGAGAAGTCAGAGTGAGGACAGTGAATTGAAAGGCAGAAGACGGCACTGAGGATGGAAGAAACTGACATCATGCACTTCCTGGTGTGATGTGCTGAGAAGAATAACATTGCTTTTAAGACATTCCTGCAAAGATGCATCCCTGCATCTAATCTAATGAGACAATCCCAAATTGAGGGACAGTCTGCAAAACAACTGGACTCATCAAAACTCCCAGTGCCACTAAAGACAAAGAAAGTCTGAGGAACGTTCTACATTTGTGGAAACTAGAGACATGATGATTAAACGCAATACATAATCCTGGACTGGATCCCAGATTGGGGTGGTGGGGGGTGGAATCTATAAAGGACATTATCGGGACATCGGTGAACTTTGAATACGGACTGCACATTAGAGAGTGAATTTAATCATTGTGTAGGTCAGTTAAGAGAATGCTCTTGTTTTTAGGAAAAACACACCTAAGTATTTAGGCGCAAAAGAGCCTGATGTTAGCAACTTGCTCAAACAGTTCAGAAAAAAAAAGATACATATACATAAACAGAGACTAATAAAGCACATGTCACAAACTGTGAAGGGTATGTGAGAGTTTCCTGTAGGATTCTTGCAACTTTTCTGTAAGTTTGAAATTATTTCAAAGTATAAAATTATGTCATCTGCCAAAAAACAAAAACAAAACAGGGGAGAGTGGACACACAAGGCCTCTCCACTTACTCCTCCGAGGCCAGGGGGTCCGGGAGGTCCGGGGGGTCCGGGGGGTCCGGGAAGTCCAGGCTGTCCAGGGATGCCATCTCGGCCAGGGGGGCCTGCGGGTCCCTGCAGGGGGAGAGGGCGGGGCCGGGGTGAGCGTGGGGCCGAGAGCCATGCCCACCTGCAGCCCCCCACAGCCCAGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACCCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACC
Task1_train_25177
A variant was discovered in gene COL1A1 (collagen type I alpha 1 chain), Chromosome 17. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Osteogenesis imperfecta type I
AGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCA
AGAGTGCAACGCTTACCCTTGGGCCTCGGGGGCCAGTGTCTCCCTTGGGTCCCTGTGGGATTGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCGGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCA
Task1_train_25178
This mutation is located in gene COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Osteogenesis imperfecta type I
TGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGC
TGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAAAATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGC
Task1_train_25179
A variant was discovered in gene COL1A1 (collagen type I alpha 1 chain), Chromosome 17. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Osteogenesis imperfecta type I
TGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGC
TGGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAATATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGC
Task1_train_25180
A variant on Chromosome 17 in gene COL1A1 (collagen type I alpha 1 chain) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Osteogenesis imperfecta type I
GGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCT
GGGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACGTGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCT
Task1_train_25181
Here’s a variant in COL1A1 (collagen type I alpha 1 chain) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Osteogenesis imperfecta type I
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACAAGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
Task1_train_25182
A genetic alteration is present in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Osteogenesis imperfecta type I
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACACGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
Task1_train_25183
A mutation found in COL1A1 (collagen type I alpha 1 chain) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Osteogenesis imperfecta type I
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACATGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
GGGGAGAAGAAACAAGAGGCCAGGTTAGAGAAGGGAGGACTGTGAGGAGTCACGGGCCGCGCAGGGGCAAAATTCGAGGGCAGGAGATTACCTCGACGCCGGTGGTTTCTTGGTCGGTGGGTGACTCTAGGGGACGAAGAGACGCGCGTTAGAGCCAAGGTTTGCTAATGCTGCTCCCGTCGGCAGAGGCCTCCAGCACGGAGGGCCAGCGAGCGCCGACCACCCCCAGCCCCAGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCAGGCCCCGAGCGCAGCCGCACCTGAGCCGTCGGGGCAGACGGGACAGCACTCGCCCTCGGGGACTTCGGCGCCGGGGCAGTTCTTGGTCTCGTCACAGATCACGTCATCGCACAACACCTTGCCGTTGTCGCAGACGCAGATCCGGCAGGGCTCGGGTTTCCACACGTCTCGGTCATGGTACCTGAGGCCGTTCTGTACGCAGGTGATTGGTGGGACTGGGACAGGCGGAAGAGGGGCGTTGTCAGTAGTGACTGCAACCCCCAGCTTAACCACCTTTCCCCCGGGTCTAAGAGGCACACTTGGATTTTTCACTTCCCGCCCCTCCCCCCGTTCTTCTTTCCTCAAATCCTTAAAAGCTCGCCTGCTCCTCATCAGCGCGGGTGACAGCGCCGAGGCGCCTGGCCAGGGAGGCTGTAACTCTTTCCAGTTCTCAGGAATTTAAACAAAGCTTTAGTCCGCGGTGGCTTCCAACTCCAACCTCAGCCCATTGGCGCTGAAGCCAAGTGAAATAAAAACCACAGGGTGAGAGGGGGAGGGCGGGGGGAGAATAGGAGGGGCCCCATCGGGAGGGCAGGCTCGTGGGGAGTGGCTTGCGTGGTAGAGACAGGAGGAGGGCGAGGGAGGAGAGAAGGGAGGTCCAGCCCTCATCCCGCCCCCATTCCCTGGGCAGGTGGGGTGGCGGGGGCGGGGCTAGGAGAATGGGAGCGGCTGATTGGAAGGGAGGCCCCCCCAAGACTTGAAATGTACCTCAAAATTAGGAGACACCCTAACCTCCAGCACCTAGACATCTTAAAAGCCCGCTCTCGGGGCCATCCCCAGTCCCCCAAAGCCAGCCAATGCCTCCAGGTCACTTTTAGCCAAAGAACCAAAAAGTCCGCAAATAGTCCAGAAGTTAGCTAACCACTCCCACCGCGCTAGCGGCTCCCCAGACGGCCACTAGGTGTCGGGCAACGCTAAGCAATGGGGCCGGGGCGGGGCCGACCTCACCGGCCCGACTACCTCTTTAAGAGGCTTGGGCTGCCCCATCCCTGGCTTTACTTTCCAGATCTAGAGGTGGGGGTCCGCACCCAGCAATAACCCGGGTCTTCCCGCTCCGGCTCCTGCCCCAGTAAGCGTTGGACCGGGAGACGCAGTGCTCAGCATCGGTCAGCAGGGGGCGCAAGGACCCCGCCCCGCCGAGTCCGCGCCAAAGTTTCTCATCCTCCACCCGCCCACGCTCCGCACCCCCTCCGCGGCTGCCCAGCACCCCCACGGCCCCAGCAACACTCTAGCCCGCAGAGAGGGCAATCTTTCCTTATGAATCATCCCACGGCCTTCCTGATTGCTTCTACATCTTGGGCTTCAAATGCCCCGCTCGGCGCCCCCATCCCATCTTCGACGTGCTTTCCTCACTCTGCACCCAGATCCCCACTTCCCCGGTTGCGCGCTCGGGATTCTCTCTTGCACCAACTCACGCCGCGCTCCACCCTCACCTCCCGCTCCCGGGGCGCGTTCAACCCCAACCTCGCCCCAGGGTGAGCTCCCTCCTGTCTCAGGGCGCCGAGGAAGAGCCCTCATCATCTCCCTTCCATTCCCGAGTCTCCGGATCATCCACGTCTCGTTTTAAGCCGCGGCCCCCGGGACCAAGCGCAAGGCGCGATATAGAGTATCCTTGCACTCCCAAAAGTTTGGGACTTACTGTCTTCGTCTTGGCCCTCGACTTGGCCTTCCTCTTGGCCGTGCGTCAGGAGGGCGGTGGCCGCTAAGAGGAGCAGGAGCCGGAGGTCCACAAAGCTGAACAGGTCTAGACCCTAGACATGTAGACTCTTTGTGGCTGGGGAGGGGGTTAGCGTCCGCTCATGCGTGGCCTCACACTCCGCGTGCCTCCTGCTCCGACCCCGAGGAGAAACTCCCGTCTGCTCCGACGACTGGCCCGGGCCCCTTTTATACTGTCCTGATGGAGAGCAGGGAGGAACCCTGCCCCTCGGAGAGGGGGAGCCGGCCGCCCGTGCCCCAGCCAATCAGAGCTGCCTGGCCCGGCCCCCAATTTGGGAGTTGGAATGGAGAGGGGGAGGAGGAGGGAAGGGAGTCCACCCCACATCTCCCCTCTTCGCAGCTCTGCCTCCCCAGCCCCCCAGCCCAGCCTGGGCCAGAGGTGCTGTGGTAGGGGTGCAGCTGGGTCCTCAGAATGGCGTGGGCTAACCAGTGGGTAGGGGTGCCCCTCTGCTCTCTTCCTGGGACCTCCAATCTAGAAGAAGTGGAACTGGGGAACTGGGGAGCTGGGTGGGGAGACTTCCAAAGGTGGAAGGGTTGGGGGTGTTGGGGAGGGGGTCCTCCTGGCTGTGCCCCAGTCACCCTCTGATATCCTGGCAAGAGCTAAGGGAGGGGCATAAAGAGGCATGCTGAGGACCTCTCCAAAACAGAGGAAGCTGGGAATTAAAAAGATGTGCCTGTTTGGGGGTGTCTTCTGGTGTGGCTAGGGGATGGAGCTTAGGAATATTTGGGGAACAATTTACAGATTCCTTTCTAGACATTAAGAATCAGATATCTGAGGGAGGGGTGCAGGCAAGGGAGTTTTAATTTTGAGGATGTCAATTCTTCTGCTGTGCTCCAGAACAGAATCAAATGCCTTCCTCCAAACCCTAGGCATGATTGAGAGATGGAGTGGGGAGGCTGAGGTGCAGGGTGAGAAACATGACTAGGTGGCCTCTGCAGAAGAAAGCTTTGGTGGTTGGGTGATGGAGCAGCCAAGGTAGGGGTGGGGGATTCTAGGGACACAGAGGTGGGGATTGGGGCTTGCAATCCCCTAAAAATTCATCCCCCAAACTCTTCCACCCCAGAGTTGGGAAGTATTTTTAGTGGGAGGCCTGTGATCATTGGTGACTTAGAGAAGAGTTTTGTTTGCCATGGCTGTGGCCAGGGGCTGCTTAGAGACCCTCCTTCCCAGCACAGTCAAACCAGAGAGAACCTGGGTGGAGGGAGGGCACTTAGCTAAAGGGGTGTCTTTCTGGGAGCTGCATAAAGCCCCTTCTCCAGTTGTACCTGGACTCAGTGTTGGGGATGTATGGGATATTTTGGGTGTCTGGGTGAAACTTTCCTTTGGGGGTGTGGGATGGGCTGCAGAGGATGATTGACTTTGTTTTAGGGGCTACTTCCCACTGCCTCATCTCTTTCTTGAAAATCCCGGTCATTGCTCTATGCCTTAGGAACCAGAGAGAATCATCTGTACACTCTGAAAGGGTCTGGGGACCCGAAGGACAGCAGGCTATATCTAAGGAAGATGGCTCTAGAACTCCACGTCCTTTCTTCCTCCATGTCCCATTCCCCCAACAAGGCTCTGCCTCAACCCCAATCTACCTCGTCCTGAGAAACTCTGTAGGGCTGAGAGAAGGCCTGGGGGTCTCCTTGCAGTGCCCTGTTCATTTCTCTCCCTCCTGTGCAGCTCCCCACCCCGGGTGCTCCAGAGCTGCAAACGTGGAAGCGGGGAGTCCCGCCTCCCCCAAACCATCCAAGATTCCATTGCCTCCCCCCGCCCCTCTCCACGCCCTCCCCCAGCTGGTTTTGTGCAACGAAGGCAAAGGGGAAAAAAAAGGAACAGAAGGGGAGGGAGCCACGTCGGCTGGCCGGCTGGCCGTGGGCAGCCAGGATGAGCGGTGCGGGTGGGGCAGCAGAGGGAGACTGCAGGGGCTATAATTAAAGGGAAAATATAGAGTTTCCAGAGAGGCAGGGCTGGAGACAGCAATGGAGGGATGGACCTTCATCAATTATCCCGACCATGTGGCAGCAACTTGTGGCCCAGGGTCTGCCCCCGCCTAGTGCCAGCGACTGCAGGGCAGGACTAGGGGGCTG
Task1_train_25184
A genetic alteration is present in XYLT2 (xylosyltransferase 2) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; not provided
GAGAGCCAGCCGGCGGGTCCCACCTGCCCCACCCCCGGAAGCCCCAGGCCGCCAGAACCTGAGTGGGGCAGCAGCTGGGGAGGCGCTGGTAGGGGCAGCTGGCTTCCCACCACACGGAGATACAGGGAGCGTGGAGGGCGCCCCCCAGCCCACGGACAATGGCTTCACCCCCAAGTGCGAGATCGTGGGCAAGGACGCACTGTCTGCACTGGCCCGGGCCAGCACCAAGCAGTGCCAGCAGGAGATCGCCAATGTGGTGTGCCTGCACCAGGCTGGGAGCCTCATGCCCAAGGCTGTGCCCCGGCACTGTCAGCTGACTGGTGAGGGACAGGGGTGCTCCAGCCCTTCCCAGGCGGGGGCAGGGGGGTGGCATGGCCCGGATCCTCACCCCTATCTCTCTGAGGAAGAAAGAGCCAAGGGGATCCTACCTCCCTGCCTAAGTCTTCATCCAGTGTACTTACTAAGTGGCAGAGGCAGAGTGGGGACCCACGAGCATGGAGCTCCAAGTCTAGGTTTCTTCGGAAGGCAGGCAGCTCCCTCTTCCCATCTCACCCCCACCCTGTGACCTAGGGTGGGCCTCGCCAACGCCTGTCCTCTGCTCTCAGGGAAGATGAGCCCCGGCATCCAGTGGGATGAGAGCCAAGCCCAGCAGCCCATGGATGGCCCCCCGGTGCGAATCGCCTACATGCTGGTGGTTCACGGCCGCGCCATCCGCCAGCTGAAGCGTCTCCTCAAGGCCGTTTATCACGAGCAGCACTTCTTTTACATCCATGTGGACAAGGTACTGTGGTGGGGAGAGGCCAAGGGGTCTGGGATGAGCAGAGCAGAAACAGAAGGTTGCAGACAGACAGAGTCTCTGACCTGGCCCAGGTAGCCTAGGAGGGAAACTGAGGCCCTGAACAGGGGAGTGGCAGCACGAGCCAGCTCAGCCGCTTAGGGGCTGGAGCCCTGCCCTGTGCTTTCCTCGTCTTGTGTCCCTTCACTCTGTCCTGGGGTGGGATTGGGGATGGCGATAACACTGGAGGCTAGCTGAGTGTCTCCTCCCCACCAGCGTTCCGACTACCTGCACCGGGAGGTGGTGGAGCTGGCCCAGGGCTATGATAACGTGCGGGTGACGCCCTGGCGCATGGTTACCATCTGGGGCGGGGCCAGCCTCCTGAGGATGTACCTGCGGAGCATGCGGGACCTGCTAGAGGTGCCTGGCTGGGCCTGGGACTTCTTCATCAACCTCAGTGCCACTGACTATCCAACCAGGTGTGGGGATGGGGCTCTGAGTCCTCTGCATGGGAGGGGACCCCTGTCTGGGCACCTGGGGTTGGAGGGCTTTGGTGGACCTTCTCTGCCCCATAAGCGTAACTCTGGGATCCGCCCTGCTCAGACATGGGCCCCTGGGCCCCAGCTATGTTTTAGGGGAGGGGTTGGTGTAAGATGATCTAAGAATTGAGCATGATAGGAGATGGGGAGGAGGAGGAGCCAGAGGTCTGTACCTGGTGTTCTGGGTCAGACAGCAAGGGGCAGAGGAAGGATGGGGTGGTCTTCCTCAGGGGCCTCTGGTGCTCACCACCCCAGACATCAGCCAGGGGTAGGGCACATGGCCAGCCAGCAATCAGGCAGAGAAGAAAAGCCAGAAGGTCCGCTCTGGGCCAGTGACTGAGCAACTATCTCATGTGGCTGCCTGTCACCCCATTCCTTCACCAGGACCAATGAGGAGCTGGTGGCATTCCTATCCAAGAACCGGGACAAGAATTTCCTCAAGTCACATGGCCGGGACAACTCCAGGTGAGGGGGTGGGGAAGGAGGCCCTGGCCCCAGAGTCTTGTCCCAACCCCTCCCACACAGTTGGGCTCGGTGGCTCCAGCCCTGGGTTTCAAAGCCTCCACACCAGTCACAGGTTGAGGAGTGTTGGTTGCCAGGCGGGTGAAAGAGCTTAGACCCCACCCTGCAGGATCCCCAGCCATGGCCTCTCTGCTGCCCACAGGTTCATCAAGAAACAGGGCCTGGACCGGCTCTTCCATGAGTGCGACTCACACATGTGGCGCCTGGGCGAGCGGCAGATCCCAGCAGGCATTGTGGTGGATGGCGGTTCTGACTGGTTCGTGCTGACACGCAGCTTTGTGGAGTATGTGGTGTACACAGATGACCCGCTTGTGGCCCAGCTGCGCCAGTTCTACACATACACACTGCTCCCAGCCGAGGTGGGTAGCCCAGCAGGCATGAAGGCCAGGGAGGGCGTGGGTTGGGCTGCCTGCAGCTCACCTTCCACTCTCCCTTGCTGCTTGCAGTCCTTCTTCCACACGGTGCTGGAGAACAGCCTGGCCTGTGAGACCCTCGTGGACAACAACCTGCGGGTCACCAACTGGAACCGCAAGCTGGGCTGCAAGTGCCAGTACAAGCACATTGTGGACTGGTGTGGCTGCTCCCCCAACGACTTCAAGCCACAGGACTTCCTCCGGCTGCAGGTGCTTGCCCGAGGCCCCAAGGCCCCTGGCTAGGTCTTCTCCCCTGGCTTTTCACCAGGAAAATGGCAGGGTGGGCCAGTAAGAGAATCTGGGGGGCCACGGCCTGCAGCAACCCTCAGGGGTCTGGGGCTACAACAGCAGCAGGAAAAGCCGCAGGAGGCTGAGCTCTAGGCAGTGCTGAGGGGCCAGCCCCACCATGCCCTCTGGGGCTTCCAGAGCCCTTCACCCTCCTTGCCTCTCCCACTCCAGCAAGTCTCCAGACCCACCTTCTTCGCCCGGAAGTTCGAGTCGACTGTGAACCAGGAGGTGCTGGAAATCCTGGACTTCCACCTGTATGGCAGCTACCCCCCCGGCACGCCAGCCCTCAAGGCCTACTGGGAGAACACCTACGACGCGGCTGATGGCCCCAGTGGGCTCAGTGATGTCATGCTCACTGCTTACACAGCCTTCGCCCGCCTCAGCCTGCACCATGCCGCCACTGCTGCACCCCCAATGGGCACCCCACTCTGCAGGTGAGACCCCCTTCTGACATACAGCAGGCCCTTGGGGTGTGGTGCCCTAGGGGGAGGCCAACCAGAGAGTGACGTCCCCTGCCCACAACAAGGCCCCAGTCTGAAGCAGGGAAAAATGCAAATACCGAAAAGACGGCTAGAGCCAGGCATGCAGGTGCTGTGGGGGTGAGATCTGGGGAAAGGAAGTGCCTGGGGATGGGACTCCCCAGAGCCCCCTCCCTGGGACTCCAGGCCAAGTCAGGTGTGCTGATGGCATCTCCCTTTCTCCCTGCTGGCACCTTAGGTTTGAGCCCAGGGGCTTGCCGTCCAGCGTGCACCTGTATTTCTATGACGACCATTTCCAGGGCTACCTGGTGACGCAGGCGGTGCAGCCCTCAGCCCAGGGGCCGGCAGAGACGCTTGAGATGTGGCTGATGCCCCAAGGGTCGCTGAAGCTGTTGGGGCGCAGTGACCAGGCCAGCCGGCTCCAGAGTCTGGAGGTGGGACAGGTCCCCCACTTGCTTTCTCCCAACCCCCACCCAGACTTGGGGTAGTGGGAAGAGAGGGACAGACACCAAGGGAGGGGTAAGGTTATTTTTCCCAGTCATGGCAGCCATGGTGATGCCCCCATGCAGACATCCTGTGTCACCCCCCAGCCTGTGCACACTGAGGAGCACCTCCTGGTTGGGGTATGCAGAGGACATGCAGGGAGCAGGGAGGGAATTATCAGTTCCACTACAACACAAGCCCAATCTTCCAGACTACAGAGATTTCGCCTAGAGGGGCAGGGACATTCGAGTTGGGCCATGAAACTACACTTCTGAGTGGCTCCTCATAGTCTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTGTCGCAGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTACCTCAGCCTCCCGCGTAGCTGGGACTACAGGCGCGCGCCACCACGCCCAGCTAATTTTTTTTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGACCAGGATGATCTCGATCTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAGAGTGCTGGGAATACAAGCGCAAGCCACCGCGCCTGGCCCCTCCTCATAGTCTCTTTC
GAGAGCCAGCCGGCGGGTCCCACCTGCCCCACCCCCGGAAGCCCCAGGCCGCCAGAACCTGAGTGGGGCAGCAGCTGGGGAGGCGCTGGTAGGGGCAGCTGGCTTCCCACCACACGGAGATACAGGGAGCGTGGAGGGCGCCCCCCAGCCCACGGACAATGGCTTCACCCCCAAGTGCGAGATCGTGGGCAAGGACGCACTGTCTGCACTGGCCCGGGCCAGCACCAAGCAGTGCCAGCAGGAGATCGCCAATGTGGTGTGCCTGCACCAGGCTGGGAGCCTCATGCCCAAGGCTGTGCCCCGGCACTGTCAGCTGACTGGTGAGGGACAGGGGTGCTCCAGCCCTTCCCAGGCGGGGGCAGGGGGGTGGCATGGCCCGGATCCTCACCCCTATCTCTCTGAGGAAGAAAGAGCCAAGGGGATCCTACCTCCCTGCCTAAGTCTTCATCCAGTGTACTTACTAAGTGGCAGAGGCAGAGTGGGGACCCACGAGCATGGAGCTCCAAGTCTAGGTTTCTTCGGAAGGCAGGCAGCTCCCTCTTCCCATCTCACCCCCACCCTGTGACCTAGGGTGGGCCTCGCCAACGCCTGTCCTCTGCTCTCAGGGAAGATGAGCCCCGGCATCCAGTGGGATGAGAGCCAAGCCCAGCAGCCCATGGATGGCCCCCCGGTGCGAATCGCCTACATGCTGGTGGTTCACGGCCGCGCCATCCGCCAGCTGAAGCGTCTCCTCAAGGCCGTTTATCACGAGCAGCACTTCTTTTACATCCATGTGGACAAGGTACTGTGGTGGGGAGAGGCCAAGGGGTCTGGGATGAGCAGAGCAGAAACAGAAGGTTGCAGACAGACAGAGTCTCTGACCTGGCCCAGGTAGCCTAGGAGGGAAACTGAGGCCCTGAACAGGGGAGTGGCAGCACGAGCCAGCTCAGCCGCTTAGGGGCTGGAGCCCTGCCCTGTGCTTTCCTCGTCTTGTGTCCCTTCACTCTGTCCTGGGGTGGGATTGGGGATGGCGATAACACTGGAGGCTAGCTGAGTGTCTCCTCCCCACCAGCGTTCCGACTACCTGCACCGGGAGGTGGTGGAGCTGGCCCAGGGCTATGATAACGTGCGGGTGACGCCCTGGCGCATGGTTACCATCTGGGGCGGGGCCAGCCTCCTGAGGATGTACCTGCGGAGCATGCGGGACCTGCTAGAGGTGCCTGGCTGGGCCTGGGACTTCTTCATCAACCTCAGTGCCACTGACTATCCAACCAGGTGTGGGGATGGGGCTCTGAGTCCTCTGCATGGGAGGGGACCCCTGTCTGGGCACCTGGGGTTGGAGGGCTTTGGTGGACCTTCTCTGCCCCATAAGCGTAACTCTGGGATCCGCCCTGCTCAGACATGGGCCCCTGGGCCCCAGCTATGTTTTAGGGGAGGGGTTGGTGTAAGATGATCTAAGAATTGAGCATGATAGGAGATGGGGAGGAGGAGGAGCCAGAGGTCTGTACCTGGTGTTCTGGGTCAGACAGCAAGGGGCAGAGGAAGGATGGGGTGGTCTTCCTCAGGGGCCTCTGGTGCTCACCACCCCAGACATCAGCCAGGGGTAGGGCACATGGCCAGCCAGCAATCAGGCAGAGAAGAAAAGCCAGAAGGTCCGCTCTGGGCCAGTGACTGAGCAACTATCTCATGTGGCTGCCTGTCACCCCATTCCTTCACCAGGACCAATGAGGAGCTGGTGGCATTCCTATCCAAGAACCGGGACAAGAATTTCCTCAAGTCACATGGCCGGGACAACTCCAGGTGAGGGGGTGGGGAAGGAGGCCCTGGCCCCAGAGTCTTGTCCCAACCCCTCCCACACAGTTGGGCTCGGTGGCTCCAGCCCTGGGTTTCAAAGCCTCCACACCAGTCACAGGTTGAGGAGTGTTGGTTGCCAGGCGGGTGAAAGAGCTTAGACCCCACCCTGCAGGATCCCCAGCCATGGCCTCTCTGCTGCCCACAGGTTCATCAAGAAACAGGGCCTGGACCGGCTCTTCCATGAGTGCGACTCACACATGTGGCGCCTGGGCGAGTGGCAGATCCCAGCAGGCATTGTGGTGGATGGCGGTTCTGACTGGTTCGTGCTGACACGCAGCTTTGTGGAGTATGTGGTGTACACAGATGACCCGCTTGTGGCCCAGCTGCGCCAGTTCTACACATACACACTGCTCCCAGCCGAGGTGGGTAGCCCAGCAGGCATGAAGGCCAGGGAGGGCGTGGGTTGGGCTGCCTGCAGCTCACCTTCCACTCTCCCTTGCTGCTTGCAGTCCTTCTTCCACACGGTGCTGGAGAACAGCCTGGCCTGTGAGACCCTCGTGGACAACAACCTGCGGGTCACCAACTGGAACCGCAAGCTGGGCTGCAAGTGCCAGTACAAGCACATTGTGGACTGGTGTGGCTGCTCCCCCAACGACTTCAAGCCACAGGACTTCCTCCGGCTGCAGGTGCTTGCCCGAGGCCCCAAGGCCCCTGGCTAGGTCTTCTCCCCTGGCTTTTCACCAGGAAAATGGCAGGGTGGGCCAGTAAGAGAATCTGGGGGGCCACGGCCTGCAGCAACCCTCAGGGGTCTGGGGCTACAACAGCAGCAGGAAAAGCCGCAGGAGGCTGAGCTCTAGGCAGTGCTGAGGGGCCAGCCCCACCATGCCCTCTGGGGCTTCCAGAGCCCTTCACCCTCCTTGCCTCTCCCACTCCAGCAAGTCTCCAGACCCACCTTCTTCGCCCGGAAGTTCGAGTCGACTGTGAACCAGGAGGTGCTGGAAATCCTGGACTTCCACCTGTATGGCAGCTACCCCCCCGGCACGCCAGCCCTCAAGGCCTACTGGGAGAACACCTACGACGCGGCTGATGGCCCCAGTGGGCTCAGTGATGTCATGCTCACTGCTTACACAGCCTTCGCCCGCCTCAGCCTGCACCATGCCGCCACTGCTGCACCCCCAATGGGCACCCCACTCTGCAGGTGAGACCCCCTTCTGACATACAGCAGGCCCTTGGGGTGTGGTGCCCTAGGGGGAGGCCAACCAGAGAGTGACGTCCCCTGCCCACAACAAGGCCCCAGTCTGAAGCAGGGAAAAATGCAAATACCGAAAAGACGGCTAGAGCCAGGCATGCAGGTGCTGTGGGGGTGAGATCTGGGGAAAGGAAGTGCCTGGGGATGGGACTCCCCAGAGCCCCCTCCCTGGGACTCCAGGCCAAGTCAGGTGTGCTGATGGCATCTCCCTTTCTCCCTGCTGGCACCTTAGGTTTGAGCCCAGGGGCTTGCCGTCCAGCGTGCACCTGTATTTCTATGACGACCATTTCCAGGGCTACCTGGTGACGCAGGCGGTGCAGCCCTCAGCCCAGGGGCCGGCAGAGACGCTTGAGATGTGGCTGATGCCCCAAGGGTCGCTGAAGCTGTTGGGGCGCAGTGACCAGGCCAGCCGGCTCCAGAGTCTGGAGGTGGGACAGGTCCCCCACTTGCTTTCTCCCAACCCCCACCCAGACTTGGGGTAGTGGGAAGAGAGGGACAGACACCAAGGGAGGGGTAAGGTTATTTTTCCCAGTCATGGCAGCCATGGTGATGCCCCCATGCAGACATCCTGTGTCACCCCCCAGCCTGTGCACACTGAGGAGCACCTCCTGGTTGGGGTATGCAGAGGACATGCAGGGAGCAGGGAGGGAATTATCAGTTCCACTACAACACAAGCCCAATCTTCCAGACTACAGAGATTTCGCCTAGAGGGGCAGGGACATTCGAGTTGGGCCATGAAACTACACTTCTGAGTGGCTCCTCATAGTCTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTGTCGCAGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTACCTCAGCCTCCCGCGTAGCTGGGACTACAGGCGCGCGCCACCACGCCCAGCTAATTTTTTTTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGACCAGGATGATCTCGATCTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAGAGTGCTGGGAATACAAGCGCAAGCCACCGCGCCTGGCCCCTCCTCATAGTCTCTTTC
Task1_train_25185
The gene CACNA1G (calcium voltage-gated channel subunit alpha1 G) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits
TCACAGCTCACTTTTCTCTGTCTCTGGGAATGTGTGTCCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGTGAGCCCCAGGCTCAGAGGTGGGGCTGTGGTGAAGGAGGCTGGAGGGGGCACAGGGCCATGCTTAGTGATACCTGCTGACTCCGGTGGAGGTGGGCTCCACGAAGAGATCAGCCCTTCACACCCTCTGCTGTCTAACCACCAGCATGTCGCAAAGCCCAGTCCATCCCACAGTGCCCCAAAAAGTGGGCCCATGGGGTCTCTAGCCGTCCTTAAAGATGAAGAAACAGAGGCTCAGAGAGGGTAAGGGGCTTGCCCAGGGCCACAGAGCTACATGGTGGAGCAGGAAGCACACGTGGCAGTGGGGGCAGGCAGCCCTGGATGTGAATCCTGTGCAAATCCTGACCCCACCATTGTCAGCTCAATGACCTGGAGCAGCTGACTTACCAGGGCCTCAGTTTCATTAACTGGTGAATGGAGTCATAATAGAATCTCCTCGGAGGTCACAATAAGGATGCAATGAGATGATGTGTATATTTCTTTAACATGGTGGAAGGGACGGATATATTGTCAAGATAATTCCTTTCCTCACTCCATATTTGCAGAAACAGAAATGCAGAAAATGAAATTGCTCGCTCAGTTTTGATTCCCAGACCCACTCTGGTTTTGGTTTCTGGATTTCCAGGGTTTTTGTGTCCCTTCTCCTACCTGGCGGAGGGCAGAGGGTGTGACCATCTCTCAGGGCCCCTCCAGCTGCAGCTCAGTTATGGAACCCTGAGAGGGAGGGCTCTCCTGGAGCCTGGAGTGTGACTCCAGCTTGACCCCTCAAGGGCTGGGGTACTTGGAGCTGATGCAGGAGGCACTTTGGGGGCAGGTGATAGGTGATTCAGCCACACATCCTAGACTTCAAATGTCTCCTTCTCCTCCTCCCCATCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGGTAGGGCTGAGGTGGGCAGGATCCATCTGTGGGCTCAGGTCACTCAGCATGGGCTGATTCCAGGACAGAAAGAGCAAGGCAGGGTGGCAAAATGCCATGAAAGAAGCATCATATTTTACAGCAGAGGCTGTTGCTGGTAGCCTGTGGGCCAAATCTGGGCATGTTTTATTGGTCTACAACATGTTTAACATGTTTTGAATTAGTGATGAATATTTTTAAACTGGTGAATTTGGGCTGTGTGCAGTGGCTCACACCTGTAATGCCAGTGCATTGGGAGGCCTAGGCAAGAGGATCACTTGAGGCCAGGAGTTGGAGACCAGCCTGGGCATCATAGCAAGACCCCCAGCTCTACAAAAAATAAAAACAATTAGCCGGGTGTGGTGGTATCATCTGGAGTCCCAGCTGAGGTGGGAGGATCTCTTGAGCCCAGGAGTTTGAGGCTGCAATAAGCTGTGATCGCACCACTGCACTCCAGCCTAAGCAATAGAACAAGACCCTGTCTCTAAAAAAAGAAAAAATAATGGTGAGTTTTACACAGAAATTCAGATTTGTGTCTACTCAGGAAAAGTCTGAAGATCTGGGAAGACTGGGCTTGCATTCCCTCAAGGCAGGAGTCAGCCAGAACAAAGAGGCAGTTTTGGATGGAGAATCTACTCTCCCCTTTACCACAGTCCCCGCCCCTCCCTACTGCTTCACATCAAACCCACACCATTCATTTCCATCGCCTGTCAGGCGGCTGTAGCTATTTGGGTTCGCAGGAACCCAGGCTGTGGGCAGCTCCTAAGACAGCTTGCCCTCGGGCTGATGCCTCCGCCTGTCCTTCCTGCTCCCCGCCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAGTAAGGAGAAGCAGATGGCTGGTCGGTAGTCTTTCCACCTCTCTCTGGGTCGTGCTTGACCTTGGCCTTGCGACTGCAGGGGGCTGGGCGCTGGGGCCGGGGGCAGGGAGAAGAGGCTCCCACCCCCCTCCTCACCTCCTTCTCCCCAAGAGCATGTCTGCCTTTAGAGCGAGCATGAAGCAGACCACTTCAGCCCCATGGGTAGGGGGAGCTGTCCCCACCCTGGGGCCTCCCAGGACCTCAGCATCATCCTCCCCAGATGATGCCAAATGGAGGTTGACACCCAGCCTCCCCGAGCTTGACTCTCAGAGGAGCCTCACTGGCTGCTCCACTGCCCCATGCCAGCATCCAGAGGCCCAGGGTGGGCAGCAAGCATCTCAACCCTGCACCCACCTAGTGTCTGCAGCTGCCGAGCAAAGCCTCAGCAGATCTCAGTAATGGACAACAGCGTAAAAGAGAACCCAGACACCCCTCCCTCCCTATCTCTAACAAAACTTTCTACCATGATATATATATATATATATATATATTTCTGCTAAACTTAAAAAAAGAAAAAGCAAAAACAAAAACAAAAAAAGAAAACTCCCCTTGGCTTGGGGAAGTTCTGGAATAACCTGGGGCCCTGGAGCCCCTCACCTCCTCACCTGTGCTCCCCAGCATCTCTTGGCATTGGGTGGGTGAAGCCCCCATCCGTCCGTCCTCATGCCCTTATGCCATGGGTGGGCCGAGACTAAGTGAGAAGACAGAGGCCAGGAAGGATGTGAGAGACACAGCAGGCGCCCAGGCCCCTTTGTTTCTGGGGCATCCCCAGATGCGTCTGCACCTGTCTCCCTCTCTCCCGGGCTCCAGGGCTCCCATCTGCCTGGTACAGCGTAATCTCCGCGCCTCTCTCTCTCTCTCAGTCACGGCCCACGTCTCTCTAAGTGTCTTTGTGTGTGGGTTTATCTAAGCCTTTGTGTGTCTGTCTGTGTGTCTCTCTCTGTTTGGGGTGAGGGTTTCCCATGCTCTCTTCACCTTTTCACAAATCGTCTTCCTTCCGCCGATAAGATGGGTGCGGTGGCCTGAGTTTTCCTTTGGTGTGTTCACATGTGAGTACCACCAAATGAGTGAGGGGTTGCCGTGCCCCTGCCTCCCCTCTGCCCTCAGCTCTATCTCCCTCGGCCTGGGAGTGGCACTCTGAGGCGGGGGGAGAGTGTGGGAGTTGCAGACGAGGGTGGAGGTGGGAGGGGGCCTGTGTTCCCTGTGAAGAGCGGGAGCTGCTCCAGGATGTGGGGGAGACACTGGCCTCTGGGCAGCAATGGGAGGTGCCGTTCTCCACGTCCCCAACCCTCACTATCAGCACCCCCAAGGCCTTCTGCTCGGCTCAGGGTAGGGGTCCGGGTTCGGCTTCCCTGTGGATATCTGCAGCTGAGCAGGTGCAGTGTCCCCTGTGGCCACCGTCCCACTCCTGCTCCATCCTCCCCACCCCCACCTCACAGTCAGGCAGATGGAATTCTTTTGGCAGGCGGCACTTGTGGCCCCTGCCTGCCCAGCTGGCTCCCCTTCTGGGGTCTGTAGCTGTCTCAGGTGCAGCTGAGGCCACAACGCAGGAGAAGCGGACATCTGTTCTGATGACCGGCTGCCTGCCCCTCCCGGTGCCTCCCTGCCCCGTGACCCTGACCAGCTAGCCACATTGCTTGTCTTCCTCAAGTGCCCTGTGCCCCCAGCTTCGGGCTGGACATTCAGAGCCAGCCACCCAATGGGCTCAGCGCACCCCACCCATAGGCAGAGTGAGGTGGGAGCTGAGGGGAAGCCGCCCCTGAGGGGCCCTGCCCAGCGCACCTGGTCCGGCCAGTGACCAATGTCGTGTTTCGTTCTTTTAGATCTAATGCTGGACGATGTAATTGCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGGTACTGCGTCTGGGGTG
TCACAGCTCACTTTTCTCTGTCTCTGGGAATGTGTGTCCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGTGAGCCCCAGGCTCAGAGGTGGGGCTGTGGTGAAGGAGGCTGGAGGGGGCACAGGGCCATGCTTAGTGATACCTGCTGACTCCGGTGGAGGTGGGCTCCACGAAGAGATCAGCCCTTCACACCCTCTGCTGTCTAACCACCAGCATGTCGCAAAGCCCAGTCCATCCCACAGTGCCCCAAAAAGTGGGCCCATGGGGTCTCTAGCCGTCCTTAAAGATGAAGAAACAGAGGCTCAGAGAGGGTAAGGGGCTTGCCCAGGGCCACAGAGCTACATGGTGGAGCAGGAAGCACACGTGGCAGTGGGGGCAGGCAGCCCTGGATGTGAATCCTGTGCAAATCCTGACCCCACCATTGTCAGCTCAATGACCTGGAGCAGCTGACTTACCAGGGCCTCAGTTTCATTAACTGGTGAATGGAGTCATAATAGAATCTCCTCGGAGGTCACAATAAGGATGCAATGAGATGATGTGTATATTTCTTTAACATGGTGGAAGGGACGGATATATTGTCAAGATAATTCCTTTCCTCACTCCATATTTGCAGAAACAGAAATGCAGAAAATGAAATTGCTCGCTCAGTTTTGATTCCCAGACCCACTCTGGTTTTGGTTTCTGGATTTCCAGGGTTTTTGTGTCCCTTCTCCTACCTGGCGGAGGGCAGAGGGTGTGACCATCTCTCAGGGCCCCTCCAGCTGCAGCTCAGTTATGGAACCCTGAGAGGGAGGGCTCTCCTGGAGCCTGGAGTGTGACTCCAGCTTGACCCCTCAAGGGCTGGGGTACTTGGAGCTGATGCAGGAGGCACTTTGGGGGCAGGTGATAGGTGATTCAGCCACACATCCTAGACTTCAAATGTCTCCTTCTCCTCCTCCCCATCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGGTAGGGCTGAGGTGGGCAGGATCCATCTGTGGGCTCAGGTCACTCAGCATGGGCTGATTCCAGGACAGAAAGAGCAAGGCAGGGTGGCAAAATGCCATGAAAGAAGCATCATATTTTACAGCAGAGGCTGTTGCTGGTAGCCTGTGGGCCAAATCTGGGCATGTTTTATTGGTCTACAACATGTTTAACATGTTTTGAATTAGTGATGAATATTTTTAAACTGGTGAATTTGGGCTGTGTGCAGTGGCTCACACCTGTAATGCCAGTGCATTGGGAGGCCTAGGCAAGAGGATCACTTGAGGCCAGGAGTTGGAGACCAGCCTGGGCATCATAGCAAGACCCCCAGCTCTACAAAAAATAAAAACAATTAGCCGGGTGTGGTGGTATCATCTGGAGTCCCAGCTGAGGTGGGAGGATCTCTTGAGCCCAGGAGTTTGAGGCTGCAATAAGCTGTGATCGCACCACTGCACTCCAGCCTAAGCAATAGAACAAGACCCTGTCTCTAAAAAAAGAAAAAATAATGGTGAGTTTTACACAGAAATTCAGATTTGTGTCTACTCAGGAAAAGTCTGAAGATCTGGGAAGACTGGGCTTGCATTCCCTCAAGGCAGGAGTCAGCCAGAACAAAGAGGCAGTTTTGGATGGAGAATCTACTCTCCCCTTTACCACAGTCCCCGCCCCTCCCTACTGCTTCACATCAAACCCACACCATTCATTTCCATCGCCTGTCAGGCGGCTGTAGCTATTTGGGTTCGCAGGAACCCAGGCTGTGGGCAGCTCCTAAGACAGCTTGCCCTCGGGCTGATGCCTCCGCCTGTCCTTCCTGCTCCCCGCCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACGTGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAGTAAGGAGAAGCAGATGGCTGGTCGGTAGTCTTTCCACCTCTCTCTGGGTCGTGCTTGACCTTGGCCTTGCGACTGCAGGGGGCTGGGCGCTGGGGCCGGGGGCAGGGAGAAGAGGCTCCCACCCCCCTCCTCACCTCCTTCTCCCCAAGAGCATGTCTGCCTTTAGAGCGAGCATGAAGCAGACCACTTCAGCCCCATGGGTAGGGGGAGCTGTCCCCACCCTGGGGCCTCCCAGGACCTCAGCATCATCCTCCCCAGATGATGCCAAATGGAGGTTGACACCCAGCCTCCCCGAGCTTGACTCTCAGAGGAGCCTCACTGGCTGCTCCACTGCCCCATGCCAGCATCCAGAGGCCCAGGGTGGGCAGCAAGCATCTCAACCCTGCACCCACCTAGTGTCTGCAGCTGCCGAGCAAAGCCTCAGCAGATCTCAGTAATGGACAACAGCGTAAAAGAGAACCCAGACACCCCTCCCTCCCTATCTCTAACAAAACTTTCTACCATGATATATATATATATATATATATATTTCTGCTAAACTTAAAAAAAGAAAAAGCAAAAACAAAAACAAAAAAAGAAAACTCCCCTTGGCTTGGGGAAGTTCTGGAATAACCTGGGGCCCTGGAGCCCCTCACCTCCTCACCTGTGCTCCCCAGCATCTCTTGGCATTGGGTGGGTGAAGCCCCCATCCGTCCGTCCTCATGCCCTTATGCCATGGGTGGGCCGAGACTAAGTGAGAAGACAGAGGCCAGGAAGGATGTGAGAGACACAGCAGGCGCCCAGGCCCCTTTGTTTCTGGGGCATCCCCAGATGCGTCTGCACCTGTCTCCCTCTCTCCCGGGCTCCAGGGCTCCCATCTGCCTGGTACAGCGTAATCTCCGCGCCTCTCTCTCTCTCTCAGTCACGGCCCACGTCTCTCTAAGTGTCTTTGTGTGTGGGTTTATCTAAGCCTTTGTGTGTCTGTCTGTGTGTCTCTCTCTGTTTGGGGTGAGGGTTTCCCATGCTCTCTTCACCTTTTCACAAATCGTCTTCCTTCCGCCGATAAGATGGGTGCGGTGGCCTGAGTTTTCCTTTGGTGTGTTCACATGTGAGTACCACCAAATGAGTGAGGGGTTGCCGTGCCCCTGCCTCCCCTCTGCCCTCAGCTCTATCTCCCTCGGCCTGGGAGTGGCACTCTGAGGCGGGGGGAGAGTGTGGGAGTTGCAGACGAGGGTGGAGGTGGGAGGGGGCCTGTGTTCCCTGTGAAGAGCGGGAGCTGCTCCAGGATGTGGGGGAGACACTGGCCTCTGGGCAGCAATGGGAGGTGCCGTTCTCCACGTCCCCAACCCTCACTATCAGCACCCCCAAGGCCTTCTGCTCGGCTCAGGGTAGGGGTCCGGGTTCGGCTTCCCTGTGGATATCTGCAGCTGAGCAGGTGCAGTGTCCCCTGTGGCCACCGTCCCACTCCTGCTCCATCCTCCCCACCCCCACCTCACAGTCAGGCAGATGGAATTCTTTTGGCAGGCGGCACTTGTGGCCCCTGCCTGCCCAGCTGGCTCCCCTTCTGGGGTCTGTAGCTGTCTCAGGTGCAGCTGAGGCCACAACGCAGGAGAAGCGGACATCTGTTCTGATGACCGGCTGCCTGCCCCTCCCGGTGCCTCCCTGCCCCGTGACCCTGACCAGCTAGCCACATTGCTTGTCTTCCTCAAGTGCCCTGTGCCCCCAGCTTCGGGCTGGACATTCAGAGCCAGCCACCCAATGGGCTCAGCGCACCCCACCCATAGGCAGAGTGAGGTGGGAGCTGAGGGGAAGCCGCCCCTGAGGGGCCCTGCCCAGCGCACCTGGTCCGGCCAGTGACCAATGTCGTGTTTCGTTCTTTTAGATCTAATGCTGGACGATGTAATTGCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGGTACTGCGTCTGGGGTG
Task1_train_25186
Given this context: Chromosome 17, gene CACNA1G (calcium voltage-gated channel subunit alpha1 G) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Spinocerebellar ataxia type 42
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCACATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
Task1_train_25187
Here is a variant affecting CACNA1G (calcium voltage-gated channel subunit alpha1 G) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCACATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
Task1_train_25188
The gene CACNA1G (calcium voltage-gated channel subunit alpha1 G) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Spinocerebellar ataxia type 42
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
GGTAGGAGCGAGTGGACCAGCCATCTGGCCCCCCCACCTCCAGCTGAGGAACCTCTGGGCAAGGTTAACACAGCCTGAGCCAGGGTACCTCTGTGCCAAGCAAGTGCTAGGCACACTACATGGGTTCCTCTTGTGCCCCTTGGAGGTGGGTATCATCTTTGTTTTATAGATGAGGACACTGAGGCTCAGAGATGTTAGTTGATGTGGCCAAGGTCACACAGAAAGGGAGTGGAGGACCTGGTTTCTTCATCCAGCAAATGTTGAGCGTCTACTATGAGCTGCGCTCTGGATCTTTGAGGGTAAAAAGGCAGATGGATGCCTGCCCTTCTGGAGTTGAGATTCTAGCGAACGTCCAGCTCCAGAGCTCACCTGTGACCTTGCCACTTCTCCAGTCAGCCTCCCTTGGCTGCCTTCCAGCCGTCGGTTTCCCTGTCCATCCAATGAGGGGGTTGAATTTGTAATGCACAAGGCCCCTTCCAGTCCTGGCATGCCGTGTCATCTAGTACATTCTCATGTGATCTCCTCACCATCTCCCAAGGAGAAAGATCCTTTAGCATAAGGTTGATTCATTCATGTGAATAAGTGCCCTACTCCCTTCTGGGGTTTGGTGGCTAATGGCCAGCCATCATGATGGGAACAGAGAAGACAGGGCTCCTTGGAGTTCCCCTGCCTCTCAGACCTGGGCGGTATGATGGAGGGGCGGGGGGACAAGCCCCAGCCCTGGGCCTTAAGGGACCCTGCATCTTGCCCCCATCCCTGCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTAACGGAGAAAAGGGGGGTCTTGGGGACTTGCGTAGAGATAGAAAGGAATGAGTCTCTTGGGGAAATACCCAGGAAGACCTAGTGTCTAAGACTTTTCTTAATTCCTGAGGTTCAGCCCCCACCCTGTGGCTGACGTAGGGGACTAGGGGATGGGAAGGCATGGTCTCCAGGACCAGGAGATGGGAAGGCATGGAGAGAATTTGACAAGACAGGGCCTGGGGGATGCTGGCAGCTAGAAATCAGTGTGACCTAGCCTGGGGCTTAAGAGCACAGAGCCTGGAGCCAGACTGCCTGAACTGGATTTGAATCCTGGTCTCACCACTTAGTAGCTGGTGGCCTTGGGTAAGTTACTTAACCTCTCTGTGCCTCAGTTTCCTCATTTGTAAAATGAGAGAAAATAATAGTATCCACATCACAGAGTTGTGAGATTATGAATTCCTATTTGGTTTTGAGGGTGTTTTTCGTTTTGTTTTGTTTTGTTTTGTTTTCTGATGCCCAGGCTGGAGTGCAGCAGCTCAGTCATGGCTCACAGCAGCCTTGACCTCCTGAGTTCAAGCTGTCCTTTCACCTCAGTCTCCCAGGTAGCTGGGACTACGGGCACCCACTGCCACACGCAGCTAATTATTTTTTATTTTTATTTTTAGTAGATACAGGGTCTCACTATGTTGCCCAGGCTGTTCTCGAACTCCTGAGCTCAAGTGATCCTCCCACCTCAGACTCCCAAAGTGTTGGGACTGCAGGTGTGAGTTCCTATTTGTAAAGCTCTTAAAAGTGCCTGGTGCATAGTGAACACCATATAAGTGCTAAATTAAAAATAAAAGCAAATGAATACAAATGAAAAGCAGAGGCTTTTGAGCTAAAGTCCTAGTCCTACTCGTGCCACCAGTTGGCTGTGTGGCCTTAGATAAGCCACGCCTCTTCTCTGTGGGATGGGAGGCTGGACCCGCTGATGTCTGCCCTCCTTTCAAGCCCTGTCTTTCTGTGCCACGACTGCCCCCTCCTTCAGGAACCCCCTCCCCCAACTCAGGGAGCTGTATTCTGGGCTTTCCAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCACATTGCCCGAGGTTGGTGCCCAGCCCACGCACCTGCCCTCCTAGGGTGACCAGCCCAGGGAGAGAGAGCAAGGGTCGGCTTTGTGGCTGGTCAAGGCCTGGGCGGCTGTGGGTTCCCATGGGTCTTTCTCCCAGCTTCTGCCAAGGGAGGCTGGAGACAGGGCTGAGGATGGGGATGCAACCTGGCTGGCCCGGAGATGGCCATCCCAGCAGCCCCAGCCCAGCCCTGGTCCTGACTCTGCCAGCTGTCTGGCCGGGGACCCAAAGAGGCCAGCTCATGACGTTGTCCTGTTCTGCAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTAGCCGGGAGGTGGGGGGCCTCTGGGGAGGGGGAGGTGCTTTCCAGAGGGAAGGGGCTCAGAGAAGCTGACTGGGAGACCCAGCGGCATCGTTTCTATTTCTTCTCCTTTTTTCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGGTGAGTTGGGGTAGGGGAGGGTGGAGGAGCCAGGGCTGGAGACCAGGGGGCTCCTGGACTAACATGGGCCTCTCCCCCTTTCCCTCCTCCCCCAGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGTAAGGGCCCAGGGTTGGCCTAGGCTCCAGGGAGGCAGCCCCACTTCCTGAGCTAGGATTCCTTGGGAAGATGAATTGGCCACAAATAAAAGCATGTGACCTTCTCTCCCCCGTGCTAGAACACTCTGGAACTCCCTCTCCCAGGAACATGCTCTGACTCACACTTGTAGTGCTCCTCTGCCCCCAAACACTCCCTCCTCCTCCCCTTCCTTCCCATCCTCCAATGCTCTGTGACACCAGTGACCTGATTTTCCACAACAGCTCCAACAACTGTCCTCCCCAGCCTCACCCCTCTATTCCACCCTCCCCAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGTGAGCAGACACCCACCCCAGCCGTGAGAGGAGCTGGGGCAGGAGAAGGGTGTGGAGGGTGGTGGGCGGGAGCCAAGCGGGCAGCACACAAACCCTAGGCTCCTCCTGGAGGCTCCCGCCCTCCGTCCTGGATGCTGAGCGAGCAGTCACTGCCCCTCCCCAGGGATGGCTGCCCACACTCACCCCACAGGGCCACCCCAGCAGACGGGCCAGCTTAGCCATGCCCTGCTCCTCCAGCCTGGTCTGGCCTCCCCTTCCTGACTCATAGGTTCAAGGCTAAGTTTTCTGTTTCCTTCCTGTTTCTTTCTTACCCTTGCCCAACTGCCAAATCTCTTTCCTACCCACCCTTTAACCTGCCTGATTCTCTTCCATCTCTCCATCCTTTTATCTTCTCTTTACCGCTCTCTCTCTCTCCCCCCGCCGTGGGCTCTGCTCATTTTCCATCTCCCATCTCTCCTTCCTCCTTCGCCTTCCCTCTTCCCCACCCCCTCCTCTTTTTCTCTTTGTTGCTGTGTGTGTTTTTGTGTGTGTGCACATGTGCATGTGTGTTGTCTGGGTGTCACCTCTTTCTCCTCTGTTTCTCTTGTCAATCCCCTTCC
Task1_train_25189
Assess the clinical impact of this variant on gene COX11 (cytochrome c oxidase copper chaperone COX11), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Mitochondrial complex IV deficiency, nuclear type 23
GTTCACTAATGAGAGTCATTCTTTGTGATTTTCTCATCTGTAAATAGTAAGGCTTGGGAATACAGTAGTTTATGGTATAGAAATATTAATGCTAACAAAATAGATGAGCAATAGGAGTAGCACTGAAATCAGGCATTTGTTTTTCATATGCAGTTAATACTTGTTAACCGGTACCAGTAGACCCATTTACCGTTAGTCCTCCAAATAGGTCTGAATTTTTCCTATTTTCAGCACTACTAATCCCATGTATTTACTATTTAATGGTCACCAATGAACTATCAAAACTTATTTATTCCCCTTATACCCTCCCCTATGGAAGAAGCACATTCTTACCTTTCTTCTACTAGACTGTGACTCTCCAGCTTCCCAGTAAAGACAAGAGAGTTATCAAGGAATGGGGAAAGAGAAGGACAGGATGAATACTGGCCATTTTCTTCTCTTTATTTTAGAAGAAAGTGGATGATCAGCTCACTACCACATCAAAGGTGCCAACTCTCTAAAACGTAGACTCTGTGCAGCTTTGAAGCCTGGAAGACAATACCTACCAACATGTCAAAGCCATGGTGGCACATTTCTGCTATAATGAAGATTAAATAGAATAACAGTTCCAGGATAACACTGATTCCTGACAACAGCGTGAGATTTCAACAGAACTTGTTTGGAACAAATACTCACTTAAAACTTCAGCAGAAGAAAAATTACTTAGTCCTTAGGCCAACCAATTTAACTGCAGTGTCATGTTTCACAGGCCTTCCTACATTTAGAAATCGTCACACAGCTGTGATAAGAGTAGATTATTTTACTATGAAATAATTCTGAATAGATGAAAGCATAAAATGTGAGAAACTGAATGTATTATTCAGGAAGAATACTGAGTGCCTTCATTTAACTAAAGTTGAATGTAAAAGTCAATTTGCACTTCTTTATAATCCTCTGGTTTAGAATTATAAATTGTTAAAACCTTGATAATTGTCATTTAATTATATTTCAGGTGTCCTGAACAGGTCACTAGACTCTACATTGGGCAGCCTTTAAATATGATTCTTTGTAATGCTAAATAGCCTTTTTTTCTCTTTTTACTGCAACTTAATATTTCTATTTAGAACACAGAAAATGAAAATATTTAGAATAAGTTGTACATTTGATGACAAATAAATCACTATTAAAACAATTTAATACTTTTTTTTTTTAACAAAGGTTTGTTTCCAGAAGAACTTTTGATGTCAGTAAATCTTCACAATCCCACCTGTACATTTTAACATTCATGGACTTGTAATGGTGATGCTTTGGCTAACAGCCTAGTAGATGTATTTTATTTCAATTTTATGATACTACAGTTTCAAAGTAATTATTCAGAACTCTGAATATAAAATAGCCCTAAACCTTAAAGGACAAATCAAATTTGAAATAAGAATTTAAATCTTTGGACAAGCTGTTAGGGCTTAGTGACTCCTCTTCTACTTTGAGCTTTTAAAATACTGACTATTCATAATGAAGGAAAATAGCAACCAACTCTTTTAGACACAATAAACATGGTTAGAAGTTCTGGCCTATGACTTGAAACAAATAACCCTGAGCATACATTTTTGAAAAACATTGTCAGATTCATTGCTGTAAGTATGAAGAGTTAATAATCTGGAAGGGAATTATGGAATTAAGCTGAACCCATGCCTGCATATTTAAAAAACAAAGCGGCTTATTTTAATAGTATCAAACTCTTCAGTATGGTATTGAATAGTCAGTCATATATTCTAGCTAGGCATATGAGTTTCTTATGATAAAAGCTGAACTTGTTCTCTCAAGTTTAAGTGAAAAAAATTAGTTGAGAAAAAATAATTATTTAAAATATAAGCCTTCATATTATTGTACAATATTTCTCCTTTGAGAAGATAGGATATATGATTTTCCCAAAAATCACAACTTTGAAGGAAGACTTAGTTGCTGACTTCAATTATATCCTGGAACTGGCAACTTGTGCCCTTCCTTTGCTTCAAAAAAAGTGTAAGAAAGAGTGATAAGATCAACTTTAATCATTCTTGGATCTTCAGCAAATTCAGGATCAATGTAGAAAAACACTGGCATATCTACTTCCTCTTGGGGATTAAGCCTTTGTTCTTCAAAACAGAAGCACTGGAAATTATAGAAAGATTTTAATAACATTTCTATTCTCGTATTACATAACAGAAACTATACAGTTCTTTTATCTTAGCATTCCAGTACACTTCGTGATTTTAATAAGCATACTATTAAATACACAGTTCTGTGATAAATTAAGAGCATCTTTTCATCTCAATGAGTTCTGCTTTAAGGATGAAGAACAAATTCTAATCTTAAAAGCAGATATCCATTTGGTTTGGTTCTCAATCTCTGCATAGCAGGTATAGATAGTGAAGAAAAATAGCTTGATGTTTAGAAGAAATTCGTTTTCAGAAATCACAAGATCTACTAAAACACTAAGTTTCATACTAAACCGTTTCATGTATCTTTATCATATTCTGTAAAGTTTACACTTTGATGTACCTGTATTTTATTGAAATACTGTCCAGCTTCAAATGGAACAATATTGTATGTAGAAATTCCAATTACTGGTTTGTCAGTAGGATTCTTAGCTCTGTAAAACGCCAGTGCAGTCTCTCCTGGCACCACCTGTTTTAAAGAATATATATATTATCAATACTTTGAATCTCACAAAGTTCCTCTTTTCCCTGCTAAATTAGTCTCATTATTTTGCCTATTCATCAGACCATAATACCTAATCTAATGTAGGGTTCAGCAAAATAAATTGTGAATATTACCCATAAACATATCTGAGTTTAAAAACTTACTTGCATATGTCAATGAAGAACCAATGTTCTAATATCCATAATTAGTTATGAACTGTCCTCTTGTATATTTGAGGTCTTCAAGGAATAATCGGCAAATTACATTATTTAAAATGTGTCCAAGCCAATCATATCACAGCCCTAGCCCAACTTTTCTGTAACACTTATACCTGAATGTCATGATTGACTATTTTTTTTAAAAAGATACCAACATTAAACTTACCTTAAAATCAGAATAAAACTGACTGACTAGAACCTTTATTATGCCACAAAGTGTTAATACTTTGGAGAAAATAAGGGAATAGCGAGGCTTAAAAAAATTTTCCAAAGGATATTCTGTCACTTGTACCAATTCAGCCACTAATACCTTTGTATACTACCACGTAATTGGAGAAGATTCATAATCATAACCTATAAAATCTTTATTAAGAGATTCAGTCATGTTTACTAAACTGGGCAAGCACTAATATTTATAAGGCTTTTCCAATATGGGTTGAAATTAACTCACTCTGGCTAATCCTCAATTAATGAGATTTCAGTTAAAATCTTTCTTACAGTTGGTTAAAATTTTAGGAAAGCGTTTAGGTATAGTCTCAGTCTCACTGGAGTATAACATAACTATTTACTACTTATTGATTATTTCAAAGGCCCTCAATTTGTTTTCTTTTAGAAGGACAGGGATACTTTTGATATAAACCAGTAAACTACTCATTGTAACCAATGCTTTTCCACATTTTTCCCATGTCTTCTATGCCTGAGGAAAAGTCAGGAAGCTATATAGCCTGACGGTTACTGCTACTCCCAACTGTTTCACTCATCTAAACTTAATTTCAAAATACTGACGGGTTCCATTACTATAAATTTTTTTATTCCCATAGACTACTTTTTAATAGTGCTTTACACCTAATGTAACAGAATTTATACTTTAACTTTTAAGTTACATGATAGTAAAAGTCAATTTGGAACAATGGAAAATGCCATGTTTTATTAGAATCATAGTGTTAAAATTAGTCCTCTGACAGTTTAAGTGATGAAAGAAAGGAATTTACATTAATAAAGTAATCTTTTAATGACTGGTTAGTCACTTACATATATTTCTGTTTGCTGAGGTCTAAAGTTCCACTGGAGACTTGCATGCACATCTGCATTAAAGCTAATTTTAATGATTCGATCTTTAACAGGCACCATGTTTTCAATCTTGTCTGAGGCATGACCTGCAACTGCTGATCCTCCAAGTCCAGTAGTCTAGAAAAAGATACCAAATATGTTAAACA
GTTCACTAATGAGAGTCATTCTTTGTGATTTTCTCATCTGTAAATAGTAAGGCTTGGGAATACAGTAGTTTATGGTATAGAAATATTAATGCTAACAAAATAGATGAGCAATAGGAGTAGCACTGAAATCAGGCATTTGTTTTTCATATGCAGTTAATACTTGTTAACCGGTACCAGTAGACCCATTTACCGTTAGTCCTCCAAATAGGTCTGAATTTTTCCTATTTTCAGCACTACTAATCCCATGTATTTACTATTTAATGGTCACCAATGAACTATCAAAACTTATTTATTCCCCTTATACCCTCCCCTATGGAAGAAGCACATTCTTACCTTTCTTCTACTAGACTGTGACTCTCCAGCTTCCCAGTAAAGACAAGAGAGTTATCAAGGAATGGGGAAAGAGAAGGACAGGATGAATACTGGCCATTTTCTTCTCTTTATTTTAGAAGAAAGTGGATGATCAGCTCACTACCACATCAAAGGTGCCAACTCTCTAAAACGTAGACTCTGTGCAGCTTTGAAGCCTGGAAGACAATACCTACCAACATGTCAAAGCCATGGTGGCACATTTCTGCTATAATGAAGATTAAATAGAATAACAGTTCCAGGATAACACTGATTCCTGACAACAGCGTGAGATTTCAACAGAACTTGTTTGGAACAAATACTCACTTAAAACTTCAGCAGAAGAAAAATTACTTAGTCCTTAGGCCAACCAATTTAACTGCAGTGTCATGTTTCACAGGCCTTCCTACATTTAGAAATCGTCACACAGCTGTGATAAGAGTAGATTATTTTACTATGAAATAATTCTGAATAGATGAAAGCATAAAATGTGAGAAACTGAATGTATTATTCAGGAAGAATACTGAGTGCCTTCATTTAACTAAAGTTGAATGTAAAAGTCAATTTGCACTTCTTTATAATCCTCTGGTTTAGAATTATAAATTGTTAAAACCTTGATAATTGTCATTTAATTATATTTCAGGTGTCCTGAACAGGTCACTAGACTCTACATTGGGCAGCCTTTAAATATGATTCTTTGTAATGCTAAATAGCCTTTTTTTCTCTTTTTACTGCAACTTAATATTTCTATTTAGAACACAGAAAATGAAAATATTTAGAATAAGTTGTACATTTGATGACAAATAAATCACTATTAAAACAATTTAATACTTTTTTTTTTTAACAAAGGTTTGTTTCCAGAAGAACTTTTGATGTCAGTAAATCTTCACAATCCCACCTGTACATTTTAACATTCATGGACTTGTAATGGTGATGCTTTGGCTAACAGCCTAGTAGATGTATTTTATTTCAATTTTATGATACTACAGTTTCAAAGTAATTATTCAGAACTCTGAATATAAAATAGCCCTAAACCTTAAAGGACAAATCAAATTTGAAATAAGAATTTAAATCTTTGGACAAGCTGTTAGGGCTTAGTGACTCCTCTTCTACTTTGAGCTTTTAAAATACTGACTATTCATAATGAAGGAAAATAGCAACCAACTCTTTTAGACACAATAAACATGGTTAGAAGTTCTGGCCTATGACTTGAAACAAATAACCCTGAGCATACATTTTTGAAAAACATTGTCAGATTCATTGCTGTAAGTATGAAGAGTTAATAATCTGGAAGGGAATTATGGAATTAAGCTGAACCCATGCCTGCATATTTAAAAAACAAAGCGGCTTATTTTAATAGTATCAAACTCTTCAGTATGGTATTGAATAGTCAGTCATATATTCTAGCTAGGCATATGAGTTTCTTATGATAAAAGCTGAACTTGTTCTCTCAAGTTTAAGTGAAAAAAATTAGTTGAGAAAAAATAATTATTTAAAATATAAGCCTTCATATTATTGTACAATATTTCTCCTTTGAGAAGATAGGATATATGATTTTCCCAAAAATCACAACTTTGAAGGAAGACTTAGTTGCTGACTTCAATTATATCCTGGAACTGGCAACTTGTGCCCTTCCTTTGCTTCAAAAAAAGTGTAAGAAAGAGTGATAAGATCAACTTTAATCATTCTTGGATCTTCAGGAAATTCAGGATCAATGTAGAAAAACACTGGCATATCTACTTCCTCTTGGGGATTAAGCCTTTGTTCTTCAAAACAGAAGCACTGGAAATTATAGAAAGATTTTAATAACATTTCTATTCTCGTATTACATAACAGAAACTATACAGTTCTTTTATCTTAGCATTCCAGTACACTTCGTGATTTTAATAAGCATACTATTAAATACACAGTTCTGTGATAAATTAAGAGCATCTTTTCATCTCAATGAGTTCTGCTTTAAGGATGAAGAACAAATTCTAATCTTAAAAGCAGATATCCATTTGGTTTGGTTCTCAATCTCTGCATAGCAGGTATAGATAGTGAAGAAAAATAGCTTGATGTTTAGAAGAAATTCGTTTTCAGAAATCACAAGATCTACTAAAACACTAAGTTTCATACTAAACCGTTTCATGTATCTTTATCATATTCTGTAAAGTTTACACTTTGATGTACCTGTATTTTATTGAAATACTGTCCAGCTTCAAATGGAACAATATTGTATGTAGAAATTCCAATTACTGGTTTGTCAGTAGGATTCTTAGCTCTGTAAAACGCCAGTGCAGTCTCTCCTGGCACCACCTGTTTTAAAGAATATATATATTATCAATACTTTGAATCTCACAAAGTTCCTCTTTTCCCTGCTAAATTAGTCTCATTATTTTGCCTATTCATCAGACCATAATACCTAATCTAATGTAGGGTTCAGCAAAATAAATTGTGAATATTACCCATAAACATATCTGAGTTTAAAAACTTACTTGCATATGTCAATGAAGAACCAATGTTCTAATATCCATAATTAGTTATGAACTGTCCTCTTGTATATTTGAGGTCTTCAAGGAATAATCGGCAAATTACATTATTTAAAATGTGTCCAAGCCAATCATATCACAGCCCTAGCCCAACTTTTCTGTAACACTTATACCTGAATGTCATGATTGACTATTTTTTTTAAAAAGATACCAACATTAAACTTACCTTAAAATCAGAATAAAACTGACTGACTAGAACCTTTATTATGCCACAAAGTGTTAATACTTTGGAGAAAATAAGGGAATAGCGAGGCTTAAAAAAATTTTCCAAAGGATATTCTGTCACTTGTACCAATTCAGCCACTAATACCTTTGTATACTACCACGTAATTGGAGAAGATTCATAATCATAACCTATAAAATCTTTATTAAGAGATTCAGTCATGTTTACTAAACTGGGCAAGCACTAATATTTATAAGGCTTTTCCAATATGGGTTGAAATTAACTCACTCTGGCTAATCCTCAATTAATGAGATTTCAGTTAAAATCTTTCTTACAGTTGGTTAAAATTTTAGGAAAGCGTTTAGGTATAGTCTCAGTCTCACTGGAGTATAACATAACTATTTACTACTTATTGATTATTTCAAAGGCCCTCAATTTGTTTTCTTTTAGAAGGACAGGGATACTTTTGATATAAACCAGTAAACTACTCATTGTAACCAATGCTTTTCCACATTTTTCCCATGTCTTCTATGCCTGAGGAAAAGTCAGGAAGCTATATAGCCTGACGGTTACTGCTACTCCCAACTGTTTCACTCATCTAAACTTAATTTCAAAATACTGACGGGTTCCATTACTATAAATTTTTTTATTCCCATAGACTACTTTTTAATAGTGCTTTACACCTAATGTAACAGAATTTATACTTTAACTTTTAAGTTACATGATAGTAAAAGTCAATTTGGAACAATGGAAAATGCCATGTTTTATTAGAATCATAGTGTTAAAATTAGTCCTCTGACAGTTTAAGTGATGAAAGAAAGGAATTTACATTAATAAAGTAATCTTTTAATGACTGGTTAGTCACTTACATATATTTCTGTTTGCTGAGGTCTAAAGTTCCACTGGAGACTTGCATGCACATCTGCATTAAAGCTAATTTTAATGATTCGATCTTTAACAGGCACCATGTTTTCAATCTTGTCTGAGGCATGACCTGCAACTGCTGATCCTCCAAGTCCAGTAGTCTAGAAAAAGATACCAAATATGTTAAACA
Task1_train_25190
This alteration occurs within gene NOG (noggin) located on Chromosome 17. Is it associated with a disease or is it a benign variant?
Pathogenic; NOG-related-symphlangism spectrum disorder
CAGAAAGGTAGGGCTGGAAGAGAAATCTATTAATAGTTACGTCACTAATGCGAAAAGTGAGAAAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGG
CAGAAAGGTAGGGCTGGAAGAGAAATCTATTAATAGTTACGTCACTAATGCGAAAAGTGAGAAAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCCGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGG
Task1_train_25191
This is a variant in NOG (noggin), located on Chromosome 17. Is this mutation a likely cause of disease or not?
Pathogenic; Brachydactyly type B2
AAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCA
AAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCGCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCA
Task1_train_25192
Given a variant located on Chromosome 17 and affecting NOG (noggin), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; not provided
AAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCA
AAAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCTCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCA
Task1_train_25193
Consider a variant on Chromosome 17 in gene NOG (noggin). Determine its clinical classification and disease relevance.
Pathogenic; Proximal symphalangism 1A
AAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCAC
AAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCGGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCAC
Task1_train_25194
This variant affects the gene NOG (noggin) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Tarsal-carpal coalition syndrome
AAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCAC
AAATGACTTGTCCGAGTTATATCAGGGTGGACCCCGGGCAAGACTCAGGTGCCTCTGCTGTCAGCTCACCTTTCAAGTTTCTGGTCCCCACTCGCACCCACTGAGACCAGAGACCGATTTACCTGAGGCAGAAGGTGCTGCACGCATTCTTGTGAAATTTGAGGGGACCGAGAAGGAATCTCAGGAAGTTTGTTTACACTGGGGGCCTGGAGACCTTCGGGAAAATAGCCAGAACCAAAACGGACCAGTCAGCAGACGCAGACACACACAAAGTGACAGGGACACAGAAGCAGAAGCTGAACTGGGCAGAGCGGGCAGCGGCCGACCCACCTCGCACGGCCGCCCCCGCCAGCGCCAGGTGCAGGGCTCATAGCGGGCCAGCAGAGGGCGCGCCGCCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCGGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCAC
Task1_train_25195
A mutation in NOG (noggin), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Brachydactyly type B2
CCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCA
CCCCCAGGGAGCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCGGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCA
Task1_train_25196
A sequence alteration has been identified in NOG (noggin) on Chromosome 17. Is it disease-inducing or harmless?
Pathogenic; not provided
GCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCC
GCCGAGCGGCGGCCGCGCGGAGCCGGGCGGGCTAGGGGAGCCGCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCTGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCC
Task1_train_25197
The gene NOG (noggin) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Proximal symphalangism 1A
GCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTA
GCAGGCGAGCCAGTCGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTACTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTA
Task1_train_25198
Assess the clinical impact of this variant on gene NOG (noggin), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Proximal symphalangism 1A
CGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTAATTATTTCAAACCT
CGCGCCCCTGAGGCTAGGCCACTCAGGGTGCAGGACCCGGCCAAGGAGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGTGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTAATTATTTCAAACCT
Task1_train_25199
Consider this mutation in NOG (noggin) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Tarsal-carpal coalition syndrome
AGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCGGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTAATTATTTCAAACCTGCGCCTGGTCCCCAGCGCAGTCTCAATGCCCCCGGCCCCGCCCGCC
AGGAGGAGGATGGTGAGGAGCGGAACCCCCTCGTGGGCCCGAGGGGCAGACAGACAGGAGTGCTTCCTAAGAATTACATCACGCTGCGCAACGCTGCGGCTCTCGGACTCCCTGGTGCAAAGGGGGGTGGGGTAGGGGCTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATGTGTGTTGGGGGGAGGGGACTTAGAGCAAGAGCCCGGGAGAGAAGAAGACGCGCTCGGGGAAAACGCTCCATGCACATGGAGAAATTTCTTGCTCCGAACTGCATGCACCGAGAAACGAGCCCCCAGCACTTCCCCGCTGCTCCCCTCCCAGTGCAAAGCACCCAGCTAGTGAGAAACCCTCCAGCCCCACCTCAAGCACCGCCCCCCCTCCCCAAACACCGGCTCTGCACCCTCCAGCCCGGCTCCAGCGCCGCCGCGAGCTTTCCCCAGGACTGGCCCTGGCGGGGCGCCTAGAGCCCCAGTTGCATTGCTCCAGGAGAAAGGAGGGGGGCGGTGCATTTTGCAGGAGGAGGAGAAGGGGGGTGGGTGGTGGGGGAGAGAGAAAATTGCGCGGAGACCTGCCAAGCGCCACCGCCGCCGCCACCGCCGCTGCCGCCGCCGCCGCCGCCGCCTGTGAGCTCCGGCGGGCAGCCGGACTGTCGGCTTCCCGGGGCATCTGGGTCCGGCGGGGCACAGCCCTGGGCGCTGCCGAAGCCGCCGCCGCCGCCTCCGCGGCGAGTACAGGCGGCTTCCCCCGGAGCCTGTGCAGCTCCAGCTCCTCGGGGGTGGAGAAGTGGGGGGTGGGGTTGTTGTTTGGGGGGAAGAAGGGGGAGGGGGCAACGCCGAGAGAGTCAGTGGTTTCCATGGTGATGGAGCTGAAAGTGCAGGAAATTTAAAGGCTTGGACCCTGCGAGACAGACAAACCGGTGCCAACGTGCGCGGACGCCGCCGCCGCCGCCGCCGCTGGAGTCCGCCGGGCAGAGCCGGCCGCGGAGCCCGGAGCAGGCGGAGGGAAGTGCCCCTAGAACCAGCTCAGCCAGCGGCGCTTGCACAGAGCGGCCGGACGAAGAGCAGCGAGAGGAGGAGGGGAGAGCGGCTCGTCCACGCGCCCTGCGCCGCCGCCGGCCCGGGAAGGCAGCGAGGAGCCGGCGCCTCCCGCGCCCCGCGGTCGCCCTGGAGTAATTTCGGATGCCCAGCCGCGGCCGCCTTCCCCAGTAGACCCGGGAGAGGAGTTGCGGCCAACTTGTGTGCCTTTCTTCCGCCCCGGTGGGAGCCGGCGCTGCGCGAAGGGCTCTCCCGGCGGCTCATGCTGCCGGCCCTGCGCCTGCCCAGCCTCGGGTGAGCCGCCTCCGGAGAGACGGGGGAGCGCGGCGGCGCCGCGGGCTCGGCGTGCTCTCCTCCGGGGACGCGGGACGAAGCAGCAGCCCCGGGCGCGCGCCAGAGGCATGGAGCGCTGCCCCAGCCTAGGGGTCACCCTCTACGCCCTGGTGGTGGTCCTGGGGCTGCGGGCGACACCGGCCGGCGGCCAGCACTATCTCCACATCCGCCCGGCACCCAGCGACAACCTGCCCCTGGTGGACCTCATCGAACACCCAGACCCTATCTTTGACCCCAAGGAAAAGGATCTGAACGAGACGCTGCTGCGCTCGCTGCTCGGGGGCCACTACGACCCAGGCTTCATGGCCACCTCGCCCCCCGAGGACCGGCCCGGCGGGGGCGGGGGTGCAGCTGGGGGCGCGGAGGACCTGGCGGAGCTGGACCAGCTGCTGCGGCAGCGGCCGTCGGGGGCCATGCCGAGCGAGATCAAAGGGCTAGAGTTCTCCGAGGGCTTGGCCCAGGGCAAGAAGCAGCGCCTAAGCAAGAAGCTGCGGAGGAAGTTACAGATGTGGCTGTGGTCGCAGACATTCTGCCCCGTGCTGTACGCGTGGAACGACCTGGGCAGCCGCTTTTGGCCGCGCTACGTGAAGGTGGGCAGCTGCTTCAGTAAGCGCTCGTGCTCCGTGCCCGAGGGCATGGTGTGCAAGCCGTCCAAGTCCGTGCACCTCACGGTGCTGCTGTGGCGCTGTCAGCGGCGCGGGGGCCAGCGCTGCGGCTGGATTCCCATCCAGTACCCCATCATTTCCGAGTGCAAGTGCTCGTGCTAGAACTCGGGGGCCCCCTGCCCGCACCCGGACACTTGATCGATCCCCACCGACGCCCCCTGCACCGCCTCCAACCAGTTCCACCACCCTCTAGCGAGGGTTTTCAATGAACTTTTTTTTTTTTTTTTTTTTTTTTTTCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGTGTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTTTAAAAAAAAGTAAGCAAAAGAAAAAAAAAAGAACAGAGAAAAGAGAGACTTATTCTGGTTGTTGCTAATAATGTTAACCTGCTATTTATATTCCAGTGCCCTTCGCATGGCGAAGCAGGGGGGAAAAGTTATTTTTTTCTTGAAGTACAAAGAGACGGGGGAACTTTTGTAGAGGACTTTTTAAAAGCTATTTTCCATTCTTCGGAAAGTGTTTTGGTTTTCCTTGGACCTCGAAGAAGCTATAGAGTTCAATGTTATTTTACAGTTATTGTAAATATAGAGAACAAATGGAATGACTAATCATTGTAAATTAAGAGTATCTGCTATTTATTCTTTATAATATCCCGTGTAGTAAATGAGAAAGAAGTGCAGAGCAGGATTAAAGAAAACCACTAAAACCGACTGCGCTCCACACTGATTTTCTGTGTTGGTGATTGATGGGGGTGGGAGGGCGTGGGAGGGGGCGGGTAGGGGATGCTGCTGTGCCTCCTACCCCGTTGGGGAAGGGGCTCATCCCCTCGGACTCCCCTCCTGTGGTATGATGGAGGTGACTTAGTTTTTTGAGGGCGTTGGGGGGGGGGGCGATATTCTCTAACCCCTCACTAAAACATCACGTGGCCTCCGCCTAGTCTCCTAGCTTTTCCCCCTATGTCACCAAAGCTCGGGCCTGTAGTGACCTCGACACCCAGCCGGCCCCCTGGAGCTGACCCCAGGCTGGGCCGAGGGGCGGGGGGAGGGTGGGCGGCCGCTTTGTCCTGCCTGACAGGCCCTTCACAATGGGGACACGTGTCTTTCACACCTACCCTGGGGGCGGAGTGCCGCTGAAACTTGACCCCCGAGGAATGGGGAGGGGGGGAGATCAGAGCGCGCCCACCCAGATCCCGCCACCCCTCCCGCCTCGTACCCCCCACCTCAATATCCAGCCCATGTTAACCCTTTGCATGCCCGGAAGCTACGGTGGTACGAACTGAGGCAATCCCTTGGAATCAACAAGGCTCACAGCCTCCGGGATCTTGCAGGTCCGAGCCCCGAAATCCCAGGCCCTCGGCCGGAGGTGCTGGGGATATCAGGGAGATTTGACACTGGCCTCCCCTCTCCCCGGGGACCTAAGGAAGACTAAGGGCCATGGTTTCGGAGGGGTCCGAATCTGGGTGAAAATCACCACCTCTGGCATCTGCTTTTGGGAAGAGAGTATGCCTGTGCTCGGGCACTTTCTCCCCTTGAGGGGTGGGGAGGAGGGAGAAATCGGAACCGGAATCTTTGCGCTTTAAGATTAGATAGGGGCAGAAGGCACGTAACCCATTAAAGGGACGTGCAAAACATCACTCCCACCCCACCCCTTAAAAAGCCAACTCCTTGGGACCGACGCCTGACTCTCGCATGCGTCCCTCCGCCTCAGTCCCCAGTGGCGCCCGTCCTCACAGCTCCACGTGGGCCAGCCTCCTGACACTGCTCAGCGCTCTCTTTATTTATCTTGGACTCCAAAGTCGCTCTCCTTTGCTCCCTCCCCACCTCCCTGCCACCTCTCCGCGCCTCCCTCCCGGCGTTCCTTCCACCCCACCCCCCACCCCCCCCAACCCCCCAAGTCCGGAGTCCCGGCGAATCTATGCTAATTATTTCAAACCTGCGCCTGGTCCCCAGCGCAGTCTCAATGCCCCCGGCCCCGCCCGCC