ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_2600
This variant impacts the gene HHAT (hedgehog acyltransferase) on Chromosome 1. Is the change likely to result in a pathogenic outcome?
Pathogenic; Chondrodysplasia-pseudohermaphroditism syndrome
CCCAGAGTGATCACATGCCCTTCAAGTATTTTATGATAGTATTCACATGTATATATATTCACACACACACACAAATCAGATTTTTTCCTGACTCTTTATCAGGCACGTCCAAGAATGCTGAAAGTTTATTCCTAGCCCTTCCAGCAGGTATGACTGTAGTCTGATTTCCAAAAGTCTGAAGAACCTGTTTGATCACTTCTGAATGGGAACAAGACGCAGCGGTTCCTGGGGGTTTCTCCTTGTAGGATGTATGGCTTTCACATTTGAACCACCATCTGCCATCACCCAAACTGTATATTCAGAAAGTGGCTTATGTTTTT...
CCCAGAGTGATCACATGCCCTTCAAGTATTTTATGATAGTATTCACATGTATATATATTCACACACACACACAAATCAGATTTTTTCCTGACTCTTTATCAGGCACGTCCAAGAATGCTGAAAGTTTATTCCTAGCCCTTCCAGCAGGTATGACTGTAGTCTGATTTCCAAAAGTCTGAAGAACCTGTTTGATCACTTCTGAATGGGAACAAGACGCAGCGGTTCCTGGGGGTTTCTCCTTGTAGGATGTATGGCTTTCACATTTGAACCACCATCTGCCATCACCCAAACTGTATATTCAGAAAGTGGCTTATGTTTTT...
Task1_train_2601
This sequence change occurs on Chromosome 1, altering KCNH1 (potassium voltage-gated channel subfamily H member 1). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; not provided
AGCTACATATTGTGTGCTCCAAAGTCAAGCAGGAATAAAGTTGGGGCTTTTCTTTTTCTTTCTTTCTTTCTTTTTTAAAATAATACTATCTATGTCTCTATGTAGTTTGAATCTCAATTCTAACTTCAGAGTAACTTAATCTCCTCCAGCCTCAGTTTTCTAATAAATCATTTGTAAAAGATAAAACACATGTCTGCAATCTCTACCAGTACCTGGCAACTTAATGGGCTAGCATACTACGTTAATTATCATCAGAGGCTGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGCGGGCAGATCAC...
AGCTACATATTGTGTGCTCCAAAGTCAAGCAGGAATAAAGTTGGGGCTTTTCTTTTTCTTTCTTTCTTTCTTTTTTAAAATAATACTATCTATGTCTCTATGTAGTTTGAATCTCAATTCTAACTTCAGAGTAACTTAATCTCCTCCAGCCTCAGTTTTCTAATAAATCATTTGTAAAAGATAAAACACATGTCTGCAATCTCTACCAGTACCTGGCAACTTAATGGGCTAGCATACTACGTTAATTATCATCAGAGGCTGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGCGGGCAGATCAC...
Task1_train_2602
Here’s a variant in KCNH1 (potassium voltage-gated channel subfamily H member 1) located on Chromosome 1. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Temple-Baraitser syndrome
TCGGGCCTCTTGTGCTTACCCCCTTCAAGAAGGATAACAGGGTTGCTGTGGAGGCTAAATGAGACACTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTG...
TCGGGCCTCTTGTGCTTACCCCCTTCAAGAAGGATAACAGGGTTGCTGTGGAGGCTAAATGAGACACTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTG...
Task1_train_2603
Here is a genetic alteration in KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Temple-Baraitser syndrome
AGGGTTGCTGTGGAGGCTAAATGAGACACTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTT...
AGGGTTGCTGTGGAGGCTAAATGAGACACTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTT...
Task1_train_2604
An alteration has been detected in KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Temple-Baraitser syndrome
CTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGT...
CTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGT...
Task1_train_2605
This mutation occurs in KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Zimmermann-Laband syndrome 1
CTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGT...
CTAGTGCAAGACCAGGCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGT...
Task1_train_2606
Here is a genetic alteration in KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; not provided
GCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGTCGAAAGAATCAGTAT...
GCATGTAGAAGAAGCACAACAAATATCTGTTCTTAATGCATGTTCAAGAAATGGTAGCTGAGGTTGTAGTAGTGGTGTTATGGTTATCACGGCAAATAGTCAGCAAAACCAAAGTAATGTTCAAGTTGAGGATTAAATTCAGTTCAATGTTTCCTTTTAAACTGTCAACTCTCAACTGACAATTCTAATGAAGGAAGACTAGGAACATAAGTAGCTGATCCCAAAGCCAGTTGAATTTGGTTTGCAATGTGTCATTATGTATTTTTACGATCATGTTATCTTTCTGTTTTCCTCATTCTAACGGTCGAAAGAATCAGTAT...
Task1_train_2607
Given a variant located on Chromosome 1 and affecting KCNH1 (potassium voltage-gated channel subfamily H member 1), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; not provided
TTTCGACTGACAAAGTGGCTCATCTCCCCCTCCCTCTAAGAGAAGGAAATCAAATCATGTCCTGAGCACAGTGCATCTGGTTGTTTATCGGGTGCCCCAAGGCTCACAAAAATGCTGTAAGTAAGCACTGCCTAGGAAATACGTGCAGTTAAGGCTGAAACAGTTCTAGAAGAGAAAAGATCTTAAATCCTTTTCTGTGACATGAGAAAGCACCTCAAATTCTAATTAAGATGAAGCAATTAGCCACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACA...
TTTCGACTGACAAAGTGGCTCATCTCCCCCTCCCTCTAAGAGAAGGAAATCAAATCATGTCCTGAGCACAGTGCATCTGGTTGTTTATCGGGTGCCCCAAGGCTCACAAAAATGCTGTAAGTAAGCACTGCCTAGGAAATACGTGCAGTTAAGGCTGAAACAGTTCTAGAAGAGAAAAGATCTTAAATCCTTTTCTGTGACATGAGAAAGCACCTCAAATTCTAATTAAGATGAAGCAATTAGCCACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACA...
Task1_train_2608
A change on Chromosome 1 affects gene KCNH1 (potassium voltage-gated channel subfamily H member 1). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Zimmermann-Laband syndrome 1
GAAGCAATTAGCCACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAG...
GAAGCAATTAGCCACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAG...
Task1_train_2609
This variant affects gene KCNH1 (potassium voltage-gated channel subfamily H member 1) located on Chromosome 1. Evaluate its biological effect and specify any disease association.
Pathogenic; Zimmermann-Laband syndrome 1
CACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTG...
CACCCACAGATCCTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTG...
Task1_train_2610
The variant affects gene KCNH1 (potassium voltage-gated channel subfamily H member 1), which is on Chromosome 1. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Zimmermann-Laband syndrome 1
CTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTT...
CTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTT...
Task1_train_2611
The variant affects gene KCNH1 (potassium voltage-gated channel subfamily H member 1), which is on Chromosome 1. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Zimmermann-Laband syndrome 1
CTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTT...
CTTAACACTGCTTCCCATGGCCAGGCAATTATCTCTATTAAAACACATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTT...
Task1_train_2612
Given this variant in gene KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; not provided
CATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTTTCCCTGGTCAGTATAACAATTTGTCAACTCCACCCTACATCAAGC...
CATTTTAAAGTAAGGAACAAACCCAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTTTCCCTGGTCAGTATAACAATTTGTCAACTCCACCCTACATCAAGC...
Task1_train_2613
This variant affects the gene KCNH1 (potassium voltage-gated channel subfamily H member 1) found on Chromosome 1. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Zimmermann-Laband syndrome 1
CAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTTTCCCTGGTCAGTATAACAATTTGTCAACTCCACCCTACATCAAGCAAAACAGTTTCTACCTACTGAAA...
CAAAGCTCCATAGGCACACACTTCCCACAAATCAATTACCCCCTTAGACACATTCCTTAAATACTCTCAGGAAAACTCTGCCTGCAGAGAGGGCTTTTATGAAAGGACTCCATCAGACATGATGAGACTGTTGCAAAAAAGGAGGTACCAAGCAGCAAATGTGACAATTTGAGGTAACAAAATCCACTCACAAAGCGGGATGCTGAATCTCTGGTCAGTTGGACAAAGCAAGGCAAGCTGAAGCCTCAGGTTTCCCTGGTCAGTATAACAATTTGTCAACTCCACCCTACATCAAGCAAAACAGTTTCTACCTACTGAAA...
Task1_train_2614
An alteration has been detected in KCNH1 (potassium voltage-gated channel subfamily H member 1) on Chromosome 1. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Temple-Baraitser syndrome
CTGAATCTAGAGCATCTGAGCATCCAAATTCTCTCCTTCCAGCTCTACATTGGCAGCATTTTGTAGGAAGAGCTACCCTTCACTGGAAAGAGAAGTGGTAATAGTTCTGTTTTCCCAGAGAAAAGGCTGCTGTCCCACCAACCGCTGGTACTGATCTGAAGGCAGAAAGGCATCATTATGCCACTAGTAAAACATGGAGTCACTGGCCAGGTCTTGATATCCCGGCAGGGAGCAAGCTGTTCCTTTCAACGTTCTCAAGCCTGAGTCCTATGAGCCGTTTAGTTCTGAAATGTGTCTTGAGCCTCAACTTGGCTTCCTAG...
CTGAATCTAGAGCATCTGAGCATCCAAATTCTCTCCTTCCAGCTCTACATTGGCAGCATTTTGTAGGAAGAGCTACCCTTCACTGGAAAGAGAAGTGGTAATAGTTCTGTTTTCCCAGAGAAAAGGCTGCTGTCCCACCAACCGCTGGTACTGATCTGAAGGCAGAAAGGCATCATTATGCCACTAGTAAAACATGGAGTCACTGGCCAGGTCTTGATATCCCGGCAGGGAGCAAGCTGTTCCTTTCAACGTTCTCAAGCCTGAGTCCTATGAGCCGTTTAGTTCTGAAATGTGTCTTGAGCCTCAACTTGGCTTCCTAG...
Task1_train_2615
A mutation in FLVCR1 (FLVCR choline and heme transporter 1), located on Chromosome 1, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Inborn genetic diseases
TAGGGTTCTAGATATCAGCACATTTTAAGATTAAATGCATGGTAAGAACTTTTGTACTATATACACCTAGTTTGAACTTAAATTTAATAACAAACTCTTTGGAGTCTCTCTCTCTCTCTTTTTTTTTTTTTCCCAAACATAGCTTCCCAAGGAGCAGAAGGGCTGAATTTTCTCTAGTTCCAGGAAGACCGCAAGGCTACTGTGCTCTGGATGTCTCGTTTTTATTTTTTTATTTTTTTATTCTCCAGATCTCAAGACGGTGTCTGGCACATACCATTCAATACAAGTTTGGTACCTGGAACCCACTGAATATGCATGTC...
TAGGGTTCTAGATATCAGCACATTTTAAGATTAAATGCATGGTAAGAACTTTTGTACTATATACACCTAGTTTGAACTTAAATTTAATAACAAACTCTTTGGAGTCTCTCTCTCTCTCTTTTTTTTTTTTTCCCAAACATAGCTTCCCAAGGAGCAGAAGGGCTGAATTTTCTCTAGTTCCAGGAAGACCGCAAGGCTACTGTGCTCTGGATGTCTCGTTTTTATTTTTTTATTTTTTTATTCTCCAGATCTCAAGACGGTGTCTGGCACATACCATTCAATACAAGTTTGGTACCTGGAACCCACTGAATATGCATGTC...
Task1_train_2616
The variant affects gene FLVCR1 (FLVCR choline and heme transporter 1), which is on Chromosome 1. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; not provided
GGTCGAGCAACCGGATCTGCTCCATCATAGCCCGTCTCAGTCGCTTCATTCAAGTCAGCGGGGTGAGGTTGAGGGGATTCCAACTTCACAAGGGCAGATTTCTCATGGACTCTCTTTCTCTGGTTGTACTGGAACACTTTCTGGCGTTATTCCTCTGCTGGGACAGCATGAACTTATGAAACGTGGTCCTGTCTGCCCTAAAGCCAGGGTCTCACCGACAAGGACAGCGATGCTGGGGCGAGAAATAAAGTTCGTCCTGGGCCTGCGTACGGTACAGCGCCCTTGGGAAGCCCTTGTGGAGTTAAGGGTGATGCCCACTT...
GGTCGAGCAACCGGATCTGCTCCATCATAGCCCGTCTCAGTCGCTTCATTCAAGTCAGCGGGGTGAGGTTGAGGGGATTCCAACTTCACAAGGGCAGATTTCTCATGGACTCTCTTTCTCTGGTTGTACTGGAACACTTTCTGGCGTTATTCCTCTGCTGGGACAGCATGAACTTATGAAACGTGGTCCTGTCTGCCCTAAAGCCAGGGTCTCACCGACAAGGACAGCGATGCTGGGGCGAGAAATAAAGTTCGTCCTGGGCCTGCGTACGGTACAGCGCCCTTGGGAAGCCCTTGTGGAGTTAAGGGTGATGCCCACTT...
Task1_train_2617
Consider a variant on Chromosome 1 in gene FLVCR1 (FLVCR choline and heme transporter 1). Determine its clinical classification and disease relevance.
Pathogenic; not provided
CAGTTCCAAGCTGCCCACTTGTTAGAGGAGCCACTGCTTACCAGGCATCTGGTTTAATAAAACATGGCTAGAGCGACTGCATGTTAAAGTGAGTAACTAGGCACTCACAAGGCACCTATAAGGTTAATGCTAAAGGTCTGAAAATAGCCGCATTCTAAGCTGACCAACAATTATAATTACACAATATTTATGGCCATACAGGACATCTCCCACCAAGTCTGCGGAATTGTCCAGATGTCCTGAGTTTTTTTTTTTTTTTTAGACAAGGTCTCACTTTGTCGCCCAGGCTAGGCTGGAGGGCAGTGTGGTGCGATCTCAGC...
CAGTTCCAAGCTGCCCACTTGTTAGAGGAGCCACTGCTTACCAGGCATCTGGTTTAATAAAACATGGCTAGAGCGACTGCATGTTAAAGTGAGTAACTAGGCACTCACAAGGCACCTATAAGGTTAATGCTAAAGGTCTGAAAATAGCCGCATTCTAAGCTGACCAACAATTATAATTACACAATATTTATGGCCATACAGGACATCTCCCACCAAGTCTGCGGAATTGTCCAGATGTCCTGAGTTTTTTTTTTTTTTTTAGACAAGGTCTCACTTTGTCGCCCAGGCTAGGCTGGAGGGCAGTGTGGTGCGATCTCAGC...
Task1_train_2618
An alteration has been detected in FLVCR1 (FLVCR choline and heme transporter 1) on Chromosome 1. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Posterior column ataxia-retinitis pigmentosa syndrome
TGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCAATTCTCCTGCCTCAACCTCCCCAGTAGCTGGGACTACAGGCGCACACCACTGCGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGACTGGTCACGAACTCCTTGGCCAGACTGGTGTCGAACTCCTGACCTCGTGATCCACCTGCCTCAGCCTCCCAAAGTGTTGGGATTACACGCGTGAGCCACTGCGCCCAGCCAAGAATTTCTTAATG...
TGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCAATTCTCCTGCCTCAACCTCCCCAGTAGCTGGGACTACAGGCGCACACCACTGCGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGACTGGTCACGAACTCCTTGGCCAGACTGGTGTCGAACTCCTGACCTCGTGATCCACCTGCCTCAGCCTCCCAAAGTGTTGGGATTACACGCGTGAGCCACTGCGCCCAGCCAAGAATTTCTTAATG...
Task1_train_2619
Mutation context: Chromosome 1, Gene FLVCR1 (FLVCR choline and heme transporter 1). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Posterior column ataxia-retinitis pigmentosa syndrome
CCTTAGCTTCATTATTTTAAAATGATAGCTTAGAGTGAAACCTACTTGATATATAGATGAAGGGAGCATATGTAAAGGATTATATTTCTTAAGTCTTTCATCCGTTATACATTTAGAAAACTTGATAGGCATAGATGTGTGTTCTTTGCCACTGTGGCTTCCTTCTCAGGGTAACTGCCATTCATTCACCAAACTCCTGTTGTGTGCATCTTTCTTAGATGAAAATTATGGCTGGCATTATGTGATCCCTGTTCTTAAGATGTTTGTGGTCTAAATGGAGCAAATAAGGCATTCACATGTGAAAAGTTAAATAATATAAC...
CCTTAGCTTCATTATTTTAAAATGATAGCTTAGAGTGAAACCTACTTGATATATAGATGAAGGGAGCATATGTAAAGGATTATATTTCTTAAGTCTTTCATCCGTTATACATTTAGAAAACTTGATAGGCATAGATGTGTGTTCTTTGCCACTGTGGCTTCCTTCTCAGGGTAACTGCCATTCATTCACCAAACTCCTGTTGTGTGCATCTTTCTTAGATGAAAATTATGGCTGGCATTATGTGATCCCTGTTCTTAAGATGTTTGTGGTCTAAATGGAGCAAATAAGGCATTCACATGTGAAAAGTTAAATAATATAAC...
Task1_train_2620
This alteration occurs within gene FLVCR1 (FLVCR choline and heme transporter 1) located on Chromosome 1. Is it associated with a disease or is it a benign variant?
Pathogenic; not provided
TGGGAATAACAAGAGAACTGGAATTAGAAGTGGAATATGAAGAGGTAACTGAATTGCTGCATCTTATGGTAAAACCTGAAGAAATGAAGGGTTGCTTCTTTTTTTTTGGGGGGGGGTGCCGGAATGTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACAGCAAGCTCTGCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTTGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTTTTGA...
TGGGAATAACAAGAGAACTGGAATTAGAAGTGGAATATGAAGAGGTAACTGAATTGCTGCATCTTATGGTAAAACCTGAAGAAATGAAGGGTTGCTTCTTTTTTTTTGGGGGGGGGTGCCGGAATGTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACAGCAAGCTCTGCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTTGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTTTTGA...
Task1_train_2621
Consider a variant on Chromosome 1 in gene USH2A (usherin). Determine its clinical classification and disease relevance.
Pathogenic; not provided
CTGCCTCCAGGAACAACACACTTCCCATTCACCAAGGAAACTAGACTGGCAGGGCTTAGAAGGCGAGCAACCTTGGTTTTCCGGCATCACTCAACACGTGGTTCTGAGCCCTGTGTCAGAATCACTGGACAGGACTTATTTAAAGAGCAGATTCTGAGCCTCCTTGAGTCTGAATCTCTGCCAGAGGCCCGGGAAACTACAATAAACAAGCACATGAGGTGATTCCTATGCGTACTTAACTTGGCAAACCATTGCAAAGAAAAAGTCCCAGGCCAGAAGTCAATAGAAAATCTGTGTTGGTGTTCTCATCCCAGTAACAA...
CTGCCTCCAGGAACAACACACTTCCCATTCACCAAGGAAACTAGACTGGCAGGGCTTAGAAGGCGAGCAACCTTGGTTTTCCGGCATCACTCAACACGTGGTTCTGAGCCCTGTGTCAGAATCACTGGACAGGACTTATTTAAAGAGCAGATTCTGAGCCTCCTTGAGTCTGAATCTCTGCCAGAGGCCCGGGAAACTACAATAAACAAGCACATGAGGTGATTCCTATGCGTACTTAACTTGGCAAACCATTGCAAAGAAAAAGTCCCAGGCCAGAAGTCAATAGAAAATCTGTGTTGGTGTTCTCATCCCAGTAACAA...
Task1_train_2622
This is a variant in USH2A (usherin), located on Chromosome 1. Is this mutation a likely cause of disease or not?
Pathogenic; not provided
CGTCCCGATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATC...
CGTCCCGATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATC...
Task1_train_2623
Consider this mutation in USH2A (usherin) on Chromosome 1. Is this a benign change or a disease-causing variant?
Pathogenic; Usher syndrome type 2A
GATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATCCTCAAA...
GATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATCCTCAAA...
Task1_train_2624
This is a variant in USH2A (usherin), located on Chromosome 1. Is this mutation a likely cause of disease or not?
Pathogenic; not provided
ATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATCCTCAAAA...
ATTTGTGGAGAGGACAGTCCTGAGGGTGGGGCAGGATGGGTTCTCAGTTCAGCTGTCGGTCCTTTGCTGCAACAGTTGAAGCAGGTGCAGGCCTCTACTCCAATAGAGTAGTTAGTGAAGGCTTGAAGGCCATGGAGAGTCTGCTGGGTGGCCATGCCTTCGGATAGCTGTGGAAGGAAGGAAGGCTAGATAAAGGCAGTGTCAAACATTAAAGGTGTTTGATGAATGTTATCCAAGATCCCACCTCCTACAAATGGAGTACCATGCCAGGCACTCTGGGAGACACAACATGGCATTTAGCATGACATTTATCCTCAAAA...
Task1_train_2625
The following genetic variant occurs in USH2A (usherin) on Chromosome 1. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; not provided
TGAGACTTCCACAGATCATGTGACCAGAATTTAACCCAATGACACAACACAATACCAGAGAAAGTTTGTGTTTCTTATATATGGGTCATTAAGTTGCGTTTAATTAGCGGCTGAAGATTTTATGCTGATTTCATCCAGCTCTCTCACGAAGGTACCATTTTTATTTGTAAGGGAGACTAGATAACTGACAGCTTGATAACGTGACACTTCTCAATAAAGGTAATGAGAAAAGAACAAAAGGGCAGGCACGTAGGTTCTGGCTGTTTCTAACAGTGTTACGTTTCCGATGGTGGCATCGGTAAGTATTTTGTTCCTTTATG...
TGAGACTTCCACAGATCATGTGACCAGAATTTAACCCAATGACACAACACAATACCAGAGAAAGTTTGTGTTTCTTATATATGGGTCATTAAGTTGCGTTTAATTAGCGGCTGAAGATTTTATGCTGATTTCATCCAGCTCTCTCACGAAGGTACCATTTTTATTTGTAAGGGAGACTAGATAACTGACAGCTTGATAACGTGACACTTCTCAATAAAGGTAATGAGAAAAGAACAAAAGGGCAGGCACGTAGGTTCTGGCTGTTTCTAACAGTGTTACGTTTCCGATGGTGGCATCGGTAAGTATTTTGTTCCTTTATG...
Task1_train_2626
Located on Chromosome 1, this mutation impacts USH2A (usherin). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Retinitis pigmentosa
TTTTGCCTCATAGCTGGTCTCTGCTACTTGAAAAGGTCTATTTACATAGCAGGGACTTCTCCTTTCCAACAAAATGAGTTTTTGTGAGTATTTAGTGCCTATGGCTGTAAATGAGCACTTTTTTCTCTATTCCCAACCACCATTGATTTTATGACACCTTCAATTTTCCCGCAGGCACCCAGCTATCTTCTTTCTACCTTTATTCCTTTTAGTTCTAGCCTTTTCCTCTTCTATTTTCTACCTCCCCTCTTTGCTCTTTGAATCACTGCTTTCTGTTCTTGTACATGTTCTGTCTCTTCCACCTTTTTGCTTTCTTAATT...
TTTTGCCTCATAGCTGGTCTCTGCTACTTGAAAAGGTCTATTTACATAGCAGGGACTTCTCCTTTCCAACAAAATGAGTTTTTGTGAGTATTTAGTGCCTATGGCTGTAAATGAGCACTTTTTTCTCTATTCCCAACCACCATTGATTTTATGACACCTTCAATTTTCCCGCAGGCACCCAGCTATCTTCTTTCTACCTTTATTCCTTTTAGTTCTAGCCTTTTCCTCTTCTATTTTCTACCTCCCCTCTTTGCTCTTTGAATCACTGCTTTCTGTTCTTGTACATGTTCTGTCTCTTCCACCTTTTTGCTTTCTTAATT...
Task1_train_2627
Here is a mutation in USH2A (usherin) on Chromosome 1. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; not provided
CCTTTTTCCCTTTGTGACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATA...
CCTTTTTCCCTTTGTGACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATA...
Task1_train_2628
This mutation is located in gene USH2A (usherin) on Chromosome 1. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Usher syndrome
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
Task1_train_2629
A genomic change on Chromosome 1 affects USH2A (usherin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Usher syndrome type 2A
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
Task1_train_2630
This mutation occurs in USH2A (usherin) on Chromosome 1. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Retinitis pigmentosa 39
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
Task1_train_2631
The gene USH2A (usherin) on Chromosome 1 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Retinitis pigmentosa 39
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
Task1_train_2632
A genomic change on Chromosome 1 affects USH2A (usherin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Usher syndrome type 2A
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
ACTTATTTTATTCCCACTTTCTTCTCCTCCTCCCCTGGTTCTCCTCTCATGCCGATCTCCACCATGACAGGGCTACCAGTTTATTGGTGATCAAATCCATAGCTGTGTATGGTAGATCTGACTTCTAAGCAATTCTGTGAAGTCAATTTTGATTTCCCACATAAAGATTATTCATTTTCTGGGTTATCCGTGGTAGTTTTTAAATTTTGGGCTGGATTCCTTCTGCTACTTAGGACTTTCCCAGACTATTTCTTCTTACTGACCAGCTGGGGGTGCTGAAAGGAGGACACACACATTTGCAATATTCAGTGAACATTAAT...
Task1_train_2633
This variant impacts the gene USH2A (usherin) on Chromosome 1. Is the change likely to result in a pathogenic outcome?
Pathogenic; not provided
TGTTTTATGTCAATGCCACTTACAGATTCAGTTAGAGTGGATAATGAAGAGATTTCTCTCACATTCTTAAATATCCTTGCAATTTATCAGATAAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAA...
TGTTTTATGTCAATGCCACTTACAGATTCAGTTAGAGTGGATAATGAAGAGATTTCTCTCACATTCTTAAATATCCTTGCAATTTATCAGATAAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAA...
Task1_train_2634
The gene USH2A (usherin) is located on Chromosome 1, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Usher syndrome type 2A
AAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCA...
AAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCA...
Task1_train_2635
A variant was discovered in gene USH2A (usherin), Chromosome 1. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Retinitis pigmentosa 39
AAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCA...
AAATTAAACTTTTCTTTCCAGCCTGGAAAAAGCATTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCA...
Task1_train_2636
This sequence variant lies in USH2A (usherin) on Chromosome 1. Is it clinically significant, and what condition might it cause if any?
Pathogenic; USH2A-related disorder
TTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTT...
TTCCTTTCATGCCTGGACAAACTCTTTCACCTCTAGAATACTTTTTGAATAAGAGTTTCAAAAGGGAGCAAATTGATATGGTTTTTGAAAGTTGGAGGTACAGTCAGGTAAAGAGGAAGCCAGTCTAGAATATACAGCTCTGCAGCTACAGTGGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTT...
Task1_train_2637
A variant was discovered in gene USH2A (usherin), Chromosome 1. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; not specified
GGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTTCAACAGCACTATATATCAGAGGTAATTATAGGAGGATCTAATCTACACATCACTAGATTACAATAATAGCTGAATTTTACCTGAGGTAGTTGGAAATCAACACTCTTTCAGCCTTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATT...
GGACCTTTTTAATGCCCTGAATCAGTGTAAGGTAATATAAAAGCCAACTCACATAGCATGTGGATTAGCTGCAGAGGATACCTGAGGAAGTTTTAATTACTGTTTAATATTTAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTTCAACAGCACTATATATCAGAGGTAATTATAGGAGGATCTAATCTACACATCACTAGATTACAATAATAGCTGAATTTTACCTGAGGTAGTTGGAAATCAACACTCTTTCAGCCTTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATT...
Task1_train_2638
A mutation found in USH2A (usherin) on Chromosome 1 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; not provided
TAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTTCAACAGCACTATATATCAGAGGTAATTATAGGAGGATCTAATCTACACATCACTAGATTACAATAATAGCTGAATTTTACCTGAGGTAGTTGGAAATCAACACTCTTTCAGCCTTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATTTTAAGCATAAAATGTCTCTTATTACCCTTCTCTCTGGGGATGTAAGTTACTTAAAATGTGATGGGGAAAACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGT...
TAATAGACCCTAAATAATTGTCATGAGTAGATGCATAAAACCACGAATGTTTCATTTCAACAGCACTATATATCAGAGGTAATTATAGGAGGATCTAATCTACACATCACTAGATTACAATAATAGCTGAATTTTACCTGAGGTAGTTGGAAATCAACACTCTTTCAGCCTTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATTTTAAGCATAAAATGTCTCTTATTACCCTTCTCTCTGGGGATGTAAGTTACTTAAAATGTGATGGGGAAAACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGT...
Task1_train_2639
Here is a mutation in USH2A (usherin) on Chromosome 1. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; not provided
TTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATTTTAAGCATAAAATGTCTCTTATTACCCTTCTCTCTGGGGATGTAAGTTACTTAAAATGTGATGGGGAAAACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGTGTGGAGAACAACGCACTTCCATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAAC...
TTTAATTTTTTTAAGTGATTCTGTTCATTTTACTAAATTTTAAGCATAAAATGTCTCTTATTACCCTTCTCTCTGGGGATGTAAGTTACTTAAAATGTGATGGGGAAAACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGTGTGGAGAACAACGCACTTCCATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAAC...
Task1_train_2640
A variant affecting Chromosome 1, within the gene USH2A (usherin), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Retinitis pigmentosa
AACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGTGTGGAGAACAACGCACTTCCATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAACAAATTTTGTTTTAGTCTAACTCTGGCTGGTAATTGCGCTCATTGATTGGCACTTTTTAACCTTAAAATAATACATCATTTTCTTCACAGTCTGGCCAGATGACCCTA...
AACTGCCAAACAATTATTTAAACAATGGGCAAGATTCTTTTGTGTGGAGAACAACGCACTTCCATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAACAAATTTTGTTTTAGTCTAACTCTGGCTGGTAATTGCGCTCATTGATTGGCACTTTTTAACCTTAAAATAATACATCATTTTCTTCACAGTCTGGCCAGATGACCCTA...
Task1_train_2641
Gene USH2A (usherin) on Chromosome 1 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Retinitis pigmentosa 39
CATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAACAAATTTTGTTTTAGTCTAACTCTGGCTGGTAATTGCGCTCATTGATTGGCACTTTTTAACCTTAAAATAATACATCATTTTCTTCACAGTCTGGCCAGATGACCCTATCGGGGCTGTCAGAACTGTCCAGGGGCCTGCGTATTTCCAGGGGGACTAGCCTCATCTCTGT...
CATGCATGTCACAGAGCCCAGATGGGACCGCTAGGAAAACATGAGCTAGCAAAGTGGCACTGTCCTGAGAAACCATAAGAAAGTAGAGTCAGAGAAGCCTTATTATTCCTGGAAGAAGTGCTGGATTTGATAAGAAGGCTCTTCACGAAACAAATTTTGTTTTAGTCTAACTCTGGCTGGTAATTGCGCTCATTGATTGGCACTTTTTAACCTTAAAATAATACATCATTTTCTTCACAGTCTGGCCAGATGACCCTATCGGGGCTGTCAGAACTGTCCAGGGGCCTGCGTATTTCCAGGGGGACTAGCCTCATCTCTGT...
Task1_train_2642
A mutation on Chromosome 1 affecting USH2A (usherin) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; not provided
ACCCACCTTCAATTCTACCTTGAAATCTTTAATAGTTCTCAAACTCCATTGGTCCTTATATAGTCCATTTTCCACAGGGTAGCCAGAGTGATTTTTAAAAACGTAAATTTGATCATGCTATTCCTTTGCTTAAAGCCTTCAGTAATTTTTCATTGCACTTGGAACAAATTCTAAACTTTACCACAGCCTACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTT...
ACCCACCTTCAATTCTACCTTGAAATCTTTAATAGTTCTCAAACTCCATTGGTCCTTATATAGTCCATTTTCCACAGGGTAGCCAGAGTGATTTTTAAAAACGTAAATTTGATCATGCTATTCCTTTGCTTAAAGCCTTCAGTAATTTTTCATTGCACTTGGAACAAATTCTAAACTTTACCACAGCCTACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTT...
Task1_train_2643
This sequence variant lies in USH2A (usherin) on Chromosome 1. Is it clinically significant, and what condition might it cause if any?
Pathogenic; not specified
TACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGC...
TACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGC...
Task1_train_2644
Located on Chromosome 1, this mutation impacts USH2A (usherin). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Retinitis pigmentosa 39
ACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGCT...
ACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGCT...
Task1_train_2645
This mutation occurs in USH2A (usherin) on Chromosome 1. Does this change lead to a known medical condition, or is it benign?
Pathogenic; not specified
ACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGCT...
ACAATGTTGGGACAATCTGTCTCCTACCAGTCCCTCCAACCTCTTCTAGTGCCATCTTTCTTTCTCCCAAATACTTCATACACACTAGCTTTCTTCTCTTTCCTTGAATACACCAAGTTCATTCCTGGCTTCAGGCCTTGCATTTGCTGTTCATTTTGTCTGGAACATTTTGCCCCCATATCCTCACATGACTAACTCTGTCTTGTCATTCAGGACTCAGCTCAAATGTCAACTTGATTCAAATGATATTCCATTCTAAAATAGCCTGAGCAGGCATAATTACATTATTCTATTTAATTTTCTTTATAGCATTCATCGCT...
Task1_train_2646
This sequence variant lies in USH2A (usherin) on Chromosome 1. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Retinitis pigmentosa 39
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
Task1_train_2647
This sequence change occurs on Chromosome 1, altering USH2A (usherin). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Retinitis pigmentosa 39
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
Task1_train_2648
The variant affects gene USH2A (usherin), which is on Chromosome 1. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Usher syndrome type 2A
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
CCACTAAAAAGTATCTTTTACACTTAAGAACACTGCTTCTAATGCTTATCATATAGGAACTAGAAGACATAATATAAAAGACTCTAGTACATAATTTACTATCTAATAAAAATATAGTACTAATTCTGAAACAGATAAAAATGAAGATAAAACAATTATCCTTTCATTTACATATTGCTTATTTTTTAGTCATATGAGAAAATTAAACATGAGGACAGTGGGAAAACATTGTACTTTAAACTATTAATTTAAAAGGGCTCTTCTGGAGTTTAATGAAAATATATTTGCTCACTGTAATTTAAATATTTTGATAAATGTTA...
Task1_train_2649
Here is a mutation in USH2A (usherin) on Chromosome 1. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Retinitis pigmentosa
TTTACAGTATTTTTCATTGAAGCGGGCTTTCTGCATTATATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAA...
TTTACAGTATTTTTCATTGAAGCGGGCTTTCTGCATTATATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAA...
Task1_train_2650
The following genetic variant occurs in USH2A (usherin) on Chromosome 1. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Usher syndrome type 2A
TTTACAGTATTTTTCATTGAAGCGGGCTTTCTGCATTATATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAA...
TTTACAGTATTTTTCATTGAAGCGGGCTTTCTGCATTATATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAA...
Task1_train_2651
The gene USH2A (usherin) on Chromosome 1 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Retinitis pigmentosa
ATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAATCAGAAATATTATTCTTCAAATTAATGTTTGCTGAGAAG...
ATTTCCTGTTTTCCCTCTCTATAGCTGCCATGGAATAGGCACTGTAATCACGAGCTTTATTTACAAAACCAACAGAGTGAAGCCACGTCCTGGTCTATAACAGATACTCTATTTCCCTTTATTCTGAATAGGAATTTGATGTGCTTTTCTCATGCAATTAGCATTAAGTGGATGAAAGAAAACTATTTCAAGAGGGTGGACATTTTAGAGCCTGCACTAATGTGCTTAGCGTAAAATGGAAATTCACATTAACCATTTTTACGTGTTCATGTGTTTTTGAATCAGAAATATTATTCTTCAAATTAATGTTTGCTGAGAAG...
Task1_train_2652
The gene USH2A (usherin) is located on Chromosome 1, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Retinitis pigmentosa
TGCTTACCTCAAAATATAATGTTGCACTAAGTCACAAGGCAACCCAATAATGACTAAATGGCTCAATGAAGGCTATTCAGCTTACAGAGGAAAAATGCAGCTACCATAAGTGGTCACAACCCAAGGTACATGGGTGAAGTGAACAACTGTCTTTCCAAACTCCCCATTCACTGATTTAATATAAAAGGAATGGTATAATGTCAATGATCCAATCTAAGGAGTCCCATGGAAATGAATGTTCAAGGTAATTCTGACCTATATGACTTGCATTGGATATATAGAAGAGTAAGCCGGGCGTGGTGGCTCATGCCTGTAATCCC...
TGCTTACCTCAAAATATAATGTTGCACTAAGTCACAAGGCAACCCAATAATGACTAAATGGCTCAATGAAGGCTATTCAGCTTACAGAGGAAAAATGCAGCTACCATAAGTGGTCACAACCCAAGGTACATGGGTGAAGTGAACAACTGTCTTTCCAAACTCCCCATTCACTGATTTAATATAAAAGGAATGGTATAATGTCAATGATCCAATCTAAGGAGTCCCATGGAAATGAATGTTCAAGGTAATTCTGACCTATATGACTTGCATTGGATATATAGAAGAGTAAGCCGGGCGTGGTGGCTCATGCCTGTAATCCC...
Task1_train_2653
An alteration has been detected in USH2A (usherin) on Chromosome 1. Is it pathogenic, and if so, what disease is involved?
Pathogenic; not provided
GTGCCTATGCAAAAAGCATGGAATTGTTCTAGGACTAATAACTTTTGACTGGGCCAATCAGCTGCCATCTATCTATCTAAATGGTGGCTCACTCAGAAAGGTTTCCAGAAGTCTGTTGAACAAAATGTTGCATTCTTGCACTGTGGCTGAGCAGTGTGGCTGAATGTTTCATTTGGATGGCTCTTGCACAGTGTGCAAAGATGTTGCTCTTCTAAAGTTTTAAGCATATGAAAAGAATCAGAGCTACTCTGTGTAAGTTTGTTTCCTCCTGGGCTTCCTCTGTCAAGGCTGGCTTCTATGAAATGTCCCTTTCTTTATTT...
GTGCCTATGCAAAAAGCATGGAATTGTTCTAGGACTAATAACTTTTGACTGGGCCAATCAGCTGCCATCTATCTATCTAAATGGTGGCTCACTCAGAAAGGTTTCCAGAAGTCTGTTGAACAAAATGTTGCATTCTTGCACTGTGGCTGAGCAGTGTGGCTGAATGTTTCATTTGGATGGCTCTTGCACAGTGTGCAAAGATGTTGCTCTTCTAAAGTTTTAAGCATATGAAAAGAATCAGAGCTACTCTGTGTAAGTTTGTTTCCTCCTGGGCTTCCTCTGTCAAGGCTGGCTTCTATGAAATGTCCCTTTCTTTATTT...
Task1_train_2654
Here is a genetic alteration in USH2A (usherin) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Retinal dystrophy
ATGGAATTGTTCTAGGACTAATAACTTTTGACTGGGCCAATCAGCTGCCATCTATCTATCTAAATGGTGGCTCACTCAGAAAGGTTTCCAGAAGTCTGTTGAACAAAATGTTGCATTCTTGCACTGTGGCTGAGCAGTGTGGCTGAATGTTTCATTTGGATGGCTCTTGCACAGTGTGCAAAGATGTTGCTCTTCTAAAGTTTTAAGCATATGAAAAGAATCAGAGCTACTCTGTGTAAGTTTGTTTCCTCCTGGGCTTCCTCTGTCAAGGCTGGCTTCTATGAAATGTCCCTTTCTTTATTTTACTCCCACATTGTTTG...
ATGGAATTGTTCTAGGACTAATAACTTTTGACTGGGCCAATCAGCTGCCATCTATCTATCTAAATGGTGGCTCACTCAGAAAGGTTTCCAGAAGTCTGTTGAACAAAATGTTGCATTCTTGCACTGTGGCTGAGCAGTGTGGCTGAATGTTTCATTTGGATGGCTCTTGCACAGTGTGCAAAGATGTTGCTCTTCTAAAGTTTTAAGCATATGAAAAGAATCAGAGCTACTCTGTGTAAGTTTGTTTCCTCCTGGGCTTCCTCTGTCAAGGCTGGCTTCTATGAAATGTCCCTTTCTTTATTTTACTCCCACATTGTTTG...
Task1_train_2655
This sequence variant lies in USH2A (usherin) on Chromosome 1. Is it clinically significant, and what condition might it cause if any?
Pathogenic; not specified
TTTTGGAAGCTGGAAAGTAGATGAATGTGGCAGAGACAATGCAATGTGCTCAGTGATGTCCATGTTTCCCTTTTCTCTCTGGGAACATGGGATGTTGAAACCTGGCTGCAGTAGGAGAAGCCACCTGACTAGATATGTCTGTGTGACTAGTGCATAGAAAGGATGTACTCTATATCCAGGTAGGAACTGTCTGTGTGCAATTGTCCCCTCTTGCGCCTTTTCCATTATGATCCAAGGGCTGCATGAAGCATCACAAGATGTAAGGGGCTTCGGTTCTAGAGATGTTACTTGGAAGACAACTGCCTAACTCATAATGAATT...
TTTTGGAAGCTGGAAAGTAGATGAATGTGGCAGAGACAATGCAATGTGCTCAGTGATGTCCATGTTTCCCTTTTCTCTCTGGGAACATGGGATGTTGAAACCTGGCTGCAGTAGGAGAAGCCACCTGACTAGATATGTCTGTGTGACTAGTGCATAGAAAGGATGTACTCTATATCCAGGTAGGAACTGTCTGTGTGCAATTGTCCCCTCTTGCGCCTTTTCCATTATGATCCAAGGGCTGCATGAAGCATCACAAGATGTAAGGGGCTTCGGTTCTAGAGATGTTACTTGGAAGACAACTGCCTAACTCATAATGAATT...
Task1_train_2656
Here is a genetic alteration in USH2A (usherin) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Retinal dystrophy
TTTTGGAAGCTGGAAAGTAGATGAATGTGGCAGAGACAATGCAATGTGCTCAGTGATGTCCATGTTTCCCTTTTCTCTCTGGGAACATGGGATGTTGAAACCTGGCTGCAGTAGGAGAAGCCACCTGACTAGATATGTCTGTGTGACTAGTGCATAGAAAGGATGTACTCTATATCCAGGTAGGAACTGTCTGTGTGCAATTGTCCCCTCTTGCGCCTTTTCCATTATGATCCAAGGGCTGCATGAAGCATCACAAGATGTAAGGGGCTTCGGTTCTAGAGATGTTACTTGGAAGACAACTGCCTAACTCATAATGAATT...
TTTTGGAAGCTGGAAAGTAGATGAATGTGGCAGAGACAATGCAATGTGCTCAGTGATGTCCATGTTTCCCTTTTCTCTCTGGGAACATGGGATGTTGAAACCTGGCTGCAGTAGGAGAAGCCACCTGACTAGATATGTCTGTGTGACTAGTGCATAGAAAGGATGTACTCTATATCCAGGTAGGAACTGTCTGTGTGCAATTGTCCCCTCTTGCGCCTTTTCCATTATGATCCAAGGGCTGCATGAAGCATCACAAGATGTAAGGGGCTTCGGTTCTAGAGATGTTACTTGGAAGACAACTGCCTAACTCATAATGAATT...
Task1_train_2657
A variant was discovered on Chromosome 1, affecting USH2A (usherin). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; not provided
CCTTATTGCTGATATGAAGACACTTTGAGTGGTCTGGATAGAAGATCAAATCAGTCACAATAGTCCCTTAGGCCAAAGCCTAGTCCAGGCAAGGCTCTTACTCTCTTTAATTCTATGAAGGCTGAGAGAGATGAGGAAGCTGCAGAAGAATAGATGAAAGCTAACAGAAGTTGGTTCATGAGGTTTAAGAAAAAAAGCCATCTTCATAACATAAAAGTGCAAGGTGAAGCAGCAAGTGCTGATGTAGAAACTGCTGCCTCAAGTTACCCAGAACACCTAGGTAAGATCACTGATGAAGGTGGCTACACTAAACAACAGAT...
CCTTATTGCTGATATGAAGACACTTTGAGTGGTCTGGATAGAAGATCAAATCAGTCACAATAGTCCCTTAGGCCAAAGCCTAGTCCAGGCAAGGCTCTTACTCTCTTTAATTCTATGAAGGCTGAGAGAGATGAGGAAGCTGCAGAAGAATAGATGAAAGCTAACAGAAGTTGGTTCATGAGGTTTAAGAAAAAAAGCCATCTTCATAACATAAAAGTGCAAGGTGAAGCAGCAAGTGCTGATGTAGAAACTGCTGCCTCAAGTTACCCAGAACACCTAGGTAAGATCACTGATGAAGGTGGCTACACTAAACAACAGAT...
Task1_train_2658
Here is a mutation in USH2A (usherin) on Chromosome 1. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; not provided
AATTTAACTGACATCCTTTATTCTCTTTTACCGCAATACCTGTGTTGCCTCTTTAAGCTCAACAATAAAAATAAGACTTTGTTTAAGGCATCATTAAATAGTGTGTCTCGTTTTAGTGTAATAAGGTATGACATTTGCATTATAAGAATAACCAAATGTGATGTTTCTTTTCAAGACTATGTGGTGAGATTTGCACACGCCTGTTTTCTAAAGCCTAACTTTTGCTTCCCTATTCATCAATTTACATTTATTTTCTATAAAAGGTGACCCGTATGATTTTTTTTTTTTTGTAGAGTAGATTTGTCTAAATCATTTTTAAA...
AATTTAACTGACATCCTTTATTCTCTTTTACCGCAATACCTGTGTTGCCTCTTTAAGCTCAACAATAAAAATAAGACTTTGTTTAAGGCATCATTAAATAGTGTGTCTCGTTTTAGTGTAATAAGGTATGACATTTGCATTATAAGAATAACCAAATGTGATGTTTCTTTTCAAGACTATGTGGTGAGATTTGCACACGCCTGTTTTCTAAAGCCTAACTTTTGCTTCCCTATTCATCAATTTACATTTATTTTCTATAAAAGGTGACCCGTATGATTTTTTTTTTTTTGTAGAGTAGATTTGTCTAAATCATTTTTAAA...
Task1_train_2659
Here is a genetic alteration in USH2A (usherin) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Retinitis pigmentosa
CCAGTGAACCAATGACACGAATTTTCCTGGGGCCCATCTCAGATGCTCCTTTTGCTTCCAACCTCACCCCTTTCCAACCCCTGAGTTGAACCCGTACCGCAAAAATTCTTTAAGTCAAATCTCGTAATTGCTTCCAATTTGTCTGTTTTGCTTTTGGCAATTAACAAACTGAAATGTTATCACGAAGGAGTTCATCTCATTTATAAGACCAGGTTTTCCCTCCACTAAAATATGCAGGCACTCTGTTCTTTATTACCAGCAGGAGATAAATGGCTGGTTTTCGTTGCTGAAGAATATATAATGGTTAAAAAGTCACTTTT...
CCAGTGAACCAATGACACGAATTTTCCTGGGGCCCATCTCAGATGCTCCTTTTGCTTCCAACCTCACCCCTTTCCAACCCCTGAGTTGAACCCGTACCGCAAAAATTCTTTAAGTCAAATCTCGTAATTGCTTCCAATTTGTCTGTTTTGCTTTTGGCAATTAACAAACTGAAATGTTATCACGAAGGAGTTCATCTCATTTATAAGACCAGGTTTTCCCTCCACTAAAATATGCAGGCACTCTGTTCTTTATTACCAGCAGGAGATAAATGGCTGGTTTTCGTTGCTGAAGAATATATAATGGTTAAAAAGTCACTTTT...
Task1_train_2660
An alteration has been detected in USH2A (usherin) on Chromosome 1. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Retinal dystrophy
TCCTCATAGAAAACATTGAATAGTATTTCCCTGCATGTGTGGATAATCTAAAGAACAAGAATTATCATTAAGAAATATTAGATGAACAAAAAAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGA...
TCCTCATAGAAAACATTGAATAGTATTTCCCTGCATGTGTGGATAATCTAAAGAACAAGAATTATCATTAAGAAATATTAGATGAACAAAAAAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGA...
Task1_train_2661
This alteration in USH2A (usherin) on Chromosome 1 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Retinitis pigmentosa 39
TCCTCATAGAAAACATTGAATAGTATTTCCCTGCATGTGTGGATAATCTAAAGAACAAGAATTATCATTAAGAAATATTAGATGAACAAAAAAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGA...
TCCTCATAGAAAACATTGAATAGTATTTCCCTGCATGTGTGGATAATCTAAAGAACAAGAATTATCATTAAGAAATATTAGATGAACAAAAAAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGA...
Task1_train_2662
A genomic change on Chromosome 1 affects USH2A (usherin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Retinitis pigmentosa
AAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGATTCATAGATTTCTTAAGTCAATAAGGACACATTAAAAGAATCATCAACAAAAAGAAGCTGAATCTGTAATATCCTTCATGATTGTGCTAGC...
AAATTGAACTCTTTCAAAATTTATTCTGATTTCTGCCAGCAAAATATTTAAAAATAGAAATGATAAATTTTCTGTTTCAATGAAATTTTTTATTTAAAATGTCATAGCATCGGGCTCTATTTAGATGAATATCTTAAGAAACCGTTGTACACCATTGCCACGTTTGACTGAATTTTGTTGAGTATCACATCATAATTTAATGATAGAAAACTCTGCCTTTTAAGATTGATTCATAGATTTCTTAAGTCAATAAGGACACATTAAAAGAATCATCAACAAAAAGAAGCTGAATCTGTAATATCCTTCATGATTGTGCTAGC...
Task1_train_2663
A variant affecting Chromosome 1, within the gene USH2A (usherin), has been observed. Determine if it's benign or associated with disease.
Pathogenic; not provided
ATTTGACGGTCATTTAAACTTCCATTTAAAAATATAAGATCTAAATTTTCATACTGTGCATTGTTTTTTAAATGAATACAAATGCCACAGGGAAATAACCTTATGAATCCTAGCACTTTAGAAAAAGTTCTTAACAATTATGATGTTCTACAAGTAATTTTGAAAATCTTGATAATCCCAACTTTGACTTGGGAAAATCTACTGACTCAGGGTGTTATTCTATCATTTGCATAATATAAAATAAATGTGTAGGTATTAGATCACCAGAATTCACATTTAGGATGGGAAGAGAGTTTTCAGTATAAACAGCAATACATGAA...
ATTTGACGGTCATTTAAACTTCCATTTAAAAATATAAGATCTAAATTTTCATACTGTGCATTGTTTTTTAAATGAATACAAATGCCACAGGGAAATAACCTTATGAATCCTAGCACTTTAGAAAAAGTTCTTAACAATTATGATGTTCTACAAGTAATTTTGAAAATCTTGATAATCCCAACTTTGACTTGGGAAAATCTACTGACTCAGGGTGTTATTCTATCATTTGCATAATATAAAATAAATGTGTAGGTATTAGATCACCAGAATTCACATTTAGGATGGGAAGAGAGTTTTCAGTATAAACAGCAATACATGAA...
Task1_train_2664
A genetic alteration is present in USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) on Chromosome 1. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Usher syndrome
AATAAAGTAGGACAGCTTTAAGGGAAACAAAGTGAACATAAAAGATAAGAGGAAACACCAAAGGGGAGAACCACTCTCTGAGCAGTTAAAACACTACAGACACCTATAGAAAACACACAGGCCACAAGATCGAGTTGCAAGGAAAGGGACAATGGGAGTGACGCTGATTTTATTAGTTCGGAAATGTGGTACAGGGCAAAGTACAGTACAGTCTAACAGATGGTCTTCTCATAAGGGACAGAGCAAAACTGACTCAAAAATAATTAAATAGTGCAATTATTCTCCAACCCTTGGGAGCATGTAGCTGCTCAGTGTTGTGG...
AATAAAGTAGGACAGCTTTAAGGGAAACAAAGTGAACATAAAAGATAAGAGGAAACACCAAAGGGGAGAACCACTCTCTGAGCAGTTAAAACACTACAGACACCTATAGAAAACACACAGGCCACAAGATCGAGTTGCAAGGAAAGGGACAATGGGAGTGACGCTGATTTTATTAGTTCGGAAATGTGGTACAGGGCAAAGTACAGTACAGTCTAACAGATGGTCTTCTCATAAGGGACAGAGCAAAACTGACTCAAAAATAATTAAATAGTGCAATTATTCTCCAACCCTTGGGAGCATGTAGCTGCTCAGTGTTGTGG...
Task1_train_2665
A variant affecting Chromosome 1, within the gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Usher syndrome type 2A
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
Task1_train_2666
Mutation context: Chromosome 1, Gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Retinitis pigmentosa 39
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
Task1_train_2667
A variant was discovered in gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2), Chromosome 1. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Usher syndrome
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
TTTATATAGATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTT...
Task1_train_2668
The gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) is located on Chromosome 1, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Usher syndrome type 2
ATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTA...
ATCAGTGTCTCTCAAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTA...
Task1_train_2669
The following genetic variant occurs in USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) on Chromosome 1. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Retinal dystrophy
AAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTATCTTACAATTTTG...
AAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTATCTTACAATTTTG...
Task1_train_2670
A genetic alteration is present in USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) on Chromosome 1. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Retinitis pigmentosa 39
AAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTATCTTACAATTTTG...
AAGGCATCTGAGTCAGAATCTTAGGGGACAGGGGTCCCTAACATCTGTATTTTTAATAACCATTCCAGGTGATGTCAATGTATCTTGAATAGTAAAAATAATGGCTAATTTTGACTTCTACGTTCCAGCTACCATACGTCAATATTTTTTCAGTGTTTTGAGACCACTGATATGGATGATACTACAGTAATAAAAATTTAATATTACTCACTAATAAAATATCTTCCAGTATCACAGACTTAGTCATAGTGTGTAGGTAAAATTATTCCCTTTGGGTCTATGGTGATGTTTTAAACTTCTGTTATTATCTTACAATTTTG...
Task1_train_2671
This gene mutation involves USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) on Chromosome 1. Is it associated with any clinical condition, or is it benign?
Pathogenic; not provided
CAGCCTCAGTCCTCAGATATGGCAGACCGTAATGTTAAGTTTTATGAAAGACTGCTTCCTTTCAGTTGCATGGGAAGTGTTAAAAGAAAGCCAAGCACATAATAGGCACTCCGTATATATTTATCTAAGTGTATTGATTTTTTTTTGTTTTGTTTGTTTTGAGACAGAGCTCTCTTGCCCAGGCTGGAGTGCAGAGGTGCAATCACAGGTCACTGCAGCCTTCGACTCCCAGTCTTCAGCAATCCTCTTGCCTCAGCTTCCCGAGTAGCTGGAACTAGCTACAGTGTCTGGCTAACTTTTTATTTTTATTTTTATTTTCA...
CAGCCTCAGTCCTCAGATATGGCAGACCGTAATGTTAAGTTTTATGAAAGACTGCTTCCTTTCAGTTGCATGGGAAGTGTTAAAAGAAAGCCAAGCACATAATAGGCACTCCGTATATATTTATCTAAGTGTATTGATTTTTTTTTGTTTTGTTTGTTTTGAGACAGAGCTCTCTTGCCCAGGCTGGAGTGCAGAGGTGCAATCACAGGTCACTGCAGCCTTCGACTCCCAGTCTTCAGCAATCCTCTTGCCTCAGCTTCCCGAGTAGCTGGAACTAGCTACAGTGTCTGGCTAACTTTTTATTTTTATTTTTATTTTCA...
Task1_train_2672
A variant affecting Chromosome 1, within the gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2), has been observed. Determine if it's benign or associated with disease.
Pathogenic; not provided
CAAGGAAAAGCAGTTACAGTTGCCCATTGTATTTAGAGAAATGTATAAAAATGTTTATAGCAGTCTTATTCATTGAAGCAAAACATGGGAACAACCAATACATCATTGGTAAGAGAAGAGAAATACTACACAGCCAAGAAAATGTATACCTATGTGGACACATAAATGACTCAGAAACAATGTTGAGTGCTAAAGAGAGAGTATAAAACCAATTTTATAAATTTCAAAAGCAAGAATTTGTAGGCATTCATTAGGTGTTCAAACTATAAAAATGCATGTGAATAACAAATACAAAATTCTGATTACCTATGACATCTGAA...
CAAGGAAAAGCAGTTACAGTTGCCCATTGTATTTAGAGAAATGTATAAAAATGTTTATAGCAGTCTTATTCATTGAAGCAAAACATGGGAACAACCAATACATCATTGGTAAGAGAAGAGAAATACTACACAGCCAAGAAAATGTATACCTATGTGGACACATAAATGACTCAGAAACAATGTTGAGTGCTAAAGAGAGAGTATAAAACCAATTTTATAAATTTCAAAAGCAAGAATTTGTAGGCATTCATTAGGTGTTCAAACTATAAAAATGCATGTGAATAACAAATACAAAATTCTGATTACCTATGACATCTGAA...
Task1_train_2673
This variant affects gene USH2A, USH2A-AS2 (usherin| USH2A antisense RNA 2) located on Chromosome 1. Evaluate its biological effect and specify any disease association.
Pathogenic; not provided
ATGTATACCTATGTGGACACATAAATGACTCAGAAACAATGTTGAGTGCTAAAGAGAGAGTATAAAACCAATTTTATAAATTTCAAAAGCAAGAATTTGTAGGCATTCATTAGGTGTTCAAACTATAAAAATGCATGTGAATAACAAATACAAAATTCTGATTACCTATGACATCTGAAAGGAGATGGAAACAAGATAGGAAAGACTTTATAGATAGACCAAAAATGATAATATTCAGTTATCAGGCGTGGTGGTAGGTCCAGGAGTGTTCACTATATTATTATACTTGATTATCTATATGTCATATGAAAAATATATAA...
ATGTATACCTATGTGGACACATAAATGACTCAGAAACAATGTTGAGTGCTAAAGAGAGAGTATAAAACCAATTTTATAAATTTCAAAAGCAAGAATTTGTAGGCATTCATTAGGTGTTCAAACTATAAAAATGCATGTGAATAACAAATACAAAATTCTGATTACCTATGACATCTGAAAGGAGATGGAAACAAGATAGGAAAGACTTTATAGATAGACCAAAAATGATAATATTCAGTTATCAGGCGTGGTGGTAGGTCCAGGAGTGTTCACTATATTATTATACTTGATTATCTATATGTCATATGAAAAATATATAA...
Task1_train_2674
Assess the clinical impact of this variant on gene USH2A (usherin), found on Chromosome 1. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Retinal dystrophy
CAGGCCTCTTCCTTTCTCTACCCATAGGCACCCCCTAAGTACTCTAGAGGGATGAATAGTGGGCTGGGTTCCAGTACGAACTGCCAGGGCCAAAGGCCAGGGGAACCTGGGTCTCTGACTGTGTGGCATAACAATGGAAATCCCTGTTCATATTTCTAATGCCCACCTTCTTTGAGAGAAGAGGCAAAGTTATTTGTGTTTGTTTTTCCAGAGCCCAATCCACTCCAATTAGCCCTACTTACATCTGTTCCCTTGGCTTTCAATACCATCCTTTGCTGGAAGTTCTGACTTCAGAACTAGACTTGTTTCTTGAGCAGCCT...
CAGGCCTCTTCCTTTCTCTACCCATAGGCACCCCCTAAGTACTCTAGAGGGATGAATAGTGGGCTGGGTTCCAGTACGAACTGCCAGGGCCAAAGGCCAGGGGAACCTGGGTCTCTGACTGTGTGGCATAACAATGGAAATCCCTGTTCATATTTCTAATGCCCACCTTCTTTGAGAGAAGAGGCAAAGTTATTTGTGTTTGTTTTTCCAGAGCCCAATCCACTCCAATTAGCCCTACTTACATCTGTTCCCTTGGCTTTCAATACCATCCTTTGCTGGAAGTTCTGACTTCAGAACTAGACTTGTTTCTTGAGCAGCCT...
Task1_train_2675
Given this context: Chromosome 1, gene USH2A (usherin) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; not specified
CAGGCCTCTTCCTTTCTCTACCCATAGGCACCCCCTAAGTACTCTAGAGGGATGAATAGTGGGCTGGGTTCCAGTACGAACTGCCAGGGCCAAAGGCCAGGGGAACCTGGGTCTCTGACTGTGTGGCATAACAATGGAAATCCCTGTTCATATTTCTAATGCCCACCTTCTTTGAGAGAAGAGGCAAAGTTATTTGTGTTTGTTTTTCCAGAGCCCAATCCACTCCAATTAGCCCTACTTACATCTGTTCCCTTGGCTTTCAATACCATCCTTTGCTGGAAGTTCTGACTTCAGAACTAGACTTGTTTCTTGAGCAGCCT...
CAGGCCTCTTCCTTTCTCTACCCATAGGCACCCCCTAAGTACTCTAGAGGGATGAATAGTGGGCTGGGTTCCAGTACGAACTGCCAGGGCCAAAGGCCAGGGGAACCTGGGTCTCTGACTGTGTGGCATAACAATGGAAATCCCTGTTCATATTTCTAATGCCCACCTTCTTTGAGAGAAGAGGCAAAGTTATTTGTGTTTGTTTTTCCAGAGCCCAATCCACTCCAATTAGCCCTACTTACATCTGTTCCCTTGGCTTTCAATACCATCCTTTGCTGGAAGTTCTGACTTCAGAACTAGACTTGTTTCTTGAGCAGCCT...
Task1_train_2676
This variant affects gene USH2A (usherin) located on Chromosome 1. Evaluate its biological effect and specify any disease association.
Pathogenic; Retinal dystrophy
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
Task1_train_2677
This mutation is located in gene USH2A (usherin) on Chromosome 1. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Usher syndrome type 2A
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
Task1_train_2678
A mutation in USH2A (usherin), located on Chromosome 1, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Retinitis pigmentosa 39
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
CCAAACCTGGCAAGTCAGCCAAAGGATCAAACCAATAACTTAGTATATACATGGTTATATTAAAAGTTAAAGGGGTCTTAAAAGTAAAGCCAAGCTACCACTAAAAAGGGCATCAGCAATGTCCCAGAACATGCCTGAACACAGAAGAACTTCTCATTCTCCAGGAATCACCAAAGCTCCAGGGAGTAGTTCAAGCCAAAATTGTGATCTCCCTGCCTTGTCCTTCAAATGGTGTGTACTCCAAGCATATTTTCTGTGCAGCTGGAGGCTTTGTTATAGACAGAAGGATCCTGCTTAGTGAGGCCAGTGTTTACAGCCTA...
Task1_train_2679
This mutation occurs in USH2A (usherin) on Chromosome 1. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Usher syndrome
CTAATGCATAGGGCAGGCAGATTCTATTCTGTAGACATGTTTCCTGCTCTTCTATTCCCATCTCCATGATCCAGCTAGTTTCTAGGGACGGGCATGTCTCTCTTCAGGTTCTTTAGTTTGCTTATATCTATGAAAAGGCAGACTAGATCTCATCTACAAGAATTATACTAATAACAGCTCTAGACACTATTGCATATGAGGTTCAGATGGGAACCACCATGATATGCAGCCTAAAGGAGAAAAGACTTGGGTGGATATAATGTTATTGAAAATGTTATTGGAAGGATGATAAATTAGGTTAACGACAGCCCCCAAGGAAG...
CTAATGCATAGGGCAGGCAGATTCTATTCTGTAGACATGTTTCCTGCTCTTCTATTCCCATCTCCATGATCCAGCTAGTTTCTAGGGACGGGCATGTCTCTCTTCAGGTTCTTTAGTTTGCTTATATCTATGAAAAGGCAGACTAGATCTCATCTACAAGAATTATACTAATAACAGCTCTAGACACTATTGCATATGAGGTTCAGATGGGAACCACCATGATATGCAGCCTAAAGGAGAAAAGACTTGGGTGGATATAATGTTATTGAAAATGTTATTGGAAGGATGATAAATTAGGTTAACGACAGCCCCCAAGGAAG...
Task1_train_2680
This alteration in USH2A, USH2A-AS1 (usherin| USH2A antisense RNA 1) on Chromosome 1 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
GGAATCTACCATATCAGTGAAGTTTTTAGGAGTTCAAGTGGCCTGAGACATGCTAGGATATCCCCTCCAAAATAAAGGACAAATTATTGCACCTTGCTTCTACCACCACTAAGAAGGAAACAAAATGTCTAGTTGACCTCTTCACATTCTGAAGGGAGCATATTCCACATTTGAGAATACTGTTCTGAGAAATTTACTGAGTAATATGGAATGCTGCCAGTTTTGAGTGTATCCCAGAGGCGGAAAGGGCTCTGCACCAGGTCCAGCCTGTGGTACAGGCAGATGAGCCACTTGGGACATAACATGTAGTAATTTTTACA...
GGAATCTACCATATCAGTGAAGTTTTTAGGAGTTCAAGTGGCCTGAGACATGCTAGGATATCCCCTCCAAAATAAAGGACAAATTATTGCACCTTGCTTCTACCACCACTAAGAAGGAAACAAAATGTCTAGTTGACCTCTTCACATTCTGAAGGGAGCATATTCCACATTTGAGAATACTGTTCTGAGAAATTTACTGAGTAATATGGAATGCTGCCAGTTTTGAGTGTATCCCAGAGGCGGAAAGGGCTCTGCACCAGGTCCAGCCTGTGGTACAGGCAGATGAGCCACTTGGGACATAACATGTAGTAATTTTTACA...
Task1_train_2681
This variant lies on Chromosome 1 and affects the gene USH2A, USH2A-AS1 (usherin| USH2A antisense RNA 1). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Autosomal recessive retinitis pigmentosa
AAAAAACAAGTCTTATGAAATAAATTATACCAACTTAGTTTCAATATATGATTATACTGGAAAAATACAAGTGACATACAAAGAGGGAGGCTTGTACACATAATATTATATTAAGAAAAAATGCCCTGTTTAATCAATATAGAGGGAGAATTCTGTCACAGAATTCTGCAAACTCAAAAAATGTCCAAATGAAGCCCTAAGCCAATTCTGAAAGGACATTAGTTAAAAATAACAATACCTGTGAAAACGCCATGGGAATAGACTGTTGAGGTGATTGTTCAGAAAGCATATTGATGTCATACCCCACAACTTTTCCTCTT...
AAAAAACAAGTCTTATGAAATAAATTATACCAACTTAGTTTCAATATATGATTATACTGGAAAAATACAAGTGACATACAAAGAGGGAGGCTTGTACACATAATATTATATTAAGAAAAAATGCCCTGTTTAATCAATATAGAGGGAGAATTCTGTCACAGAATTCTGCAAACTCAAAAAATGTCCAAATGAAGCCCTAAGCCAATTCTGAAAGGACATTAGTTAAAAATAACAATACCTGTGAAAACGCCATGGGAATAGACTGTTGAGGTGATTGTTCAGAAAGCATATTGATGTCATACCCCACAACTTTTCCTCTT...
Task1_train_2682
A genetic alteration is present in USH2A (usherin) on Chromosome 1. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; not provided
CTAAAAGAGAAAAAAACATCTCATCTTAGGATATCAAAAAGTTAATTGATTGCAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAAT...
CTAAAAGAGAAAAAAACATCTCATCTTAGGATATCAAAAAGTTAATTGATTGCAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAAT...
Task1_train_2683
Consider a variant on Chromosome 1 in gene USH2A (usherin). Determine its clinical classification and disease relevance.
Pathogenic; Usher syndrome
CATCTTAGGATATCAAAAAGTTAATTGATTGCAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAATAAATCGCTCTGTTGTGGCTGG...
CATCTTAGGATATCAAAAAGTTAATTGATTGCAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAATAAATCGCTCTGTTGTGGCTGG...
Task1_train_2684
A variant has been detected on Chromosome 1 in USH2A (usherin). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; not provided
CAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAATAAATCGCTCTGTTGTGGCTGGTGGTAGAATTATAAACAATTTCAGGGGACAT...
CAAATTTGAAAGGATTAACCTGAAGGTAAAAAGAGTGAATGTGCTGTATCTGTCATTTAGGCTGTCTGCCCAGGTCTCCATAATCTTCCTGTCTTCTGGGATACTTACCACCTTGCTTCTACCTGATGAAATGGTCCCTAAAAGCTATACTCATTTTATAAGTACGTGACACCCCTGGCCACAATGAATTGGCTCAGAGGTAACCAACCAAACAAAACTGAGTCAATTCGAATTTTCCTCTAGAAATTATAACTAAGAGGTAGCTAATAAATCGCTCTGTTGTGGCTGGTGGTAGAATTATAAACAATTTCAGGGGACAT...
Task1_train_2685
This variant affects the gene USH2A (usherin) found on Chromosome 1. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Usher syndrome
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
Task1_train_2686
This variant affects gene USH2A (usherin) located on Chromosome 1. Evaluate its biological effect and specify any disease association.
Pathogenic; Usher syndrome type 2A
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
Task1_train_2687
A variant on Chromosome 1 in gene USH2A (usherin) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Retinitis pigmentosa 39
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
Task1_train_2688
This variant impacts the gene USH2A (usherin) on Chromosome 1. Is the change likely to result in a pathogenic outcome?
Pathogenic; not provided
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
TACAGGCGAGTTAGCACACTTGGCATTTAATTCACATTCTTCTCCCTTTTTATTCTAGATGAATGACCTACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAA...
Task1_train_2689
The gene USH2A (usherin), on Chromosome 1, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Retinitis pigmentosa
ACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAATAACACTAGAAATAATAATTATTTATAATACTGAAGTAATTTAGTCTTCACAAAATATATATTTATGTT...
ACTTTAATAAAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAATAACACTAGAAATAATAATTATTTATAATACTGAAGTAATTTAGTCTTCACAAAATATATATTTATGTT...
Task1_train_2690
Here is a genetic alteration in USH2A (usherin) on Chromosome 1. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; not provided
AAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAATAACACTAGAAATAATAATTATTTATAATACTGAAGTAATTTAGTCTTCACAAAATATATATTTATGTTTCCTGCAGA...
AAATTATTGGTGCTAATGTATTTTACTGGTGATAGAATCATTAGTAAGATTTAACAGTTTTGTTAACTCTAACAGTTTGCTTTCTGAAGCGTATACAACATACACTTGTATTTTCTGGGCTTCTTTTTTTTTCATATTAACAAGGTGAAATTGAATAAAGTTACTTGCTGATCCCATTAGGAAAGTAAATATATATGCATATCAAGTTTTTGTTTTTATAAAAAGTACTACATTTGCAGAAATAACACTAGAAATAATAATTATTTATAATACTGAAGTAATTTAGTCTTCACAAAATATATATTTATGTTTCCTGCAGA...
Task1_train_2691
Assess the clinical impact of this variant on gene USH2A (usherin), found on Chromosome 1. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Usher syndrome type 2
GTCTTTCATAATTCCATCCAATAATTAGCTCCACTTTATAAGATGTTAAGAAAGAAATCTAGAGCCAGTAGTATGCTGGAGTACACTGCACTGGCTCATAAGAGCAGATTAAGTACATTTCTTCTGAAATCCATGTTCAGTGACATCTCACTGGTAGATTGAAATTGATTATGGTGGCCTTTTTTTTTTCTTAGTCAGTTGTTAATTATTTACAAGCACAGAACCACCCAAGGTTGTCTAGCATCCCTATAAAACGGACTTGAAATAGAAGTTTGAGTTCAGAAAAATCAGGTTTCAATTTCTTGTAGATCTGAATGGTG...
GTCTTTCATAATTCCATCCAATAATTAGCTCCACTTTATAAGATGTTAAGAAAGAAATCTAGAGCCAGTAGTATGCTGGAGTACACTGCACTGGCTCATAAGAGCAGATTAAGTACATTTCTTCTGAAATCCATGTTCAGTGACATCTCACTGGTAGATTGAAATTGATTATGGTGGCCTTTTTTTTTTCTTAGTCAGTTGTTAATTATTTACAAGCACAGAACCACCCAAGGTTGTCTAGCATCCCTATAAAACGGACTTGAAATAGAAGTTTGAGTTCAGAAAAATCAGGTTTCAATTTCTTGTAGATCTGAATGGTG...
Task1_train_2692
Given this context: Chromosome 1, gene USH2A (usherin) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; not provided
TTGAAATTTCTCCAATATTTGAAGACTACAGAAATAATCAATAATCAATAATATGAAAACTCATATTCTGATAGATATTGGCTATTGAGCTAGTTAAAAATTAAATTGATTTATAATATTTCTAGACTATTTCCATTTACATATGCTGTTGACTCCCAAATCCATATCTCCAATCCAGAAATCTCTCTTTTATTTATGAATTAATGAATATTTATCGCGTGATTACTATGTACCAAATACTGTGCTAAGTGCTGTGTAATACAGTAGTAAACTAAATACACAATACCCATTGCATCTCTTTCACAAAGCTCTCTTACAGT...
TTGAAATTTCTCCAATATTTGAAGACTACAGAAATAATCAATAATCAATAATATGAAAACTCATATTCTGATAGATATTGGCTATTGAGCTAGTTAAAAATTAAATTGATTTATAATATTTCTAGACTATTTCCATTTACATATGCTGTTGACTCCCAAATCCATATCTCCAATCCAGAAATCTCTCTTTTATTTATGAATTAATGAATATTTATCGCGTGATTACTATGTACCAAATACTGTGCTAAGTGCTGTGTAATACAGTAGTAAACTAAATACACAATACCCATTGCATCTCTTTCACAAAGCTCTCTTACAGT...
Task1_train_2693
A mutation in USH2A (usherin), located on Chromosome 1, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Usher syndrome type 2A
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2694
Located on Chromosome 1, this mutation impacts USH2A (usherin). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Usher syndrome type 2A
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2695
This genomic variant is located on Chromosome 1, within the USH2A (usherin) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Retinitis pigmentosa 39
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2696
The gene USH2A (usherin) is located on Chromosome 1, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Retinal dystrophy
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2697
Gene USH2A (usherin) on Chromosome 1 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Retinitis pigmentosa 39
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2698
Gene USH2A (usherin) on Chromosome 1 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Usher syndrome
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
CTATAATATCCTAAAATAAATTTCACAGAGAAGTGAAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTT...
Task1_train_2699
This variant affects gene USH2A (usherin) located on Chromosome 1. Evaluate its biological effect and specify any disease association.
Pathogenic; Retinitis pigmentosa 39
AAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTTCAGCAGTGAGACCTCACTCTGTTAGTTCATGGCTG...
AAGTAACTAACTAAAACACAAGTGTAGGGCAAGGTCCAAGAGGCAGAGATGTTCACAAGTCATACATGAGTGTATGAGACAGTGCTACCATCTGAAAAGCTAAAATGCACTAACATATAAGCCCATATTTATGTAACAAAATGATAGAAATATAAGCATTTTATATAGTTTGTATGTTTGTCCCCTCCAAATCTCATGTTGAAATGTGATCCCCAGTGTTGGAGGTGAGCCTGGTGGGAGATGTTTGGGTTATGGAGGTGGATCCTTCATGAAGTGCCTTCCCTTCAGCAGTGAGACCTCACTCTGTTAGTTCATGGCTG...