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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_44200	Located on Chromosome 16, this mutation has been observed. What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?	Benign	GCGCACACCTGTAATCCCAAATAACTCGGGAGGCTGAGAAAGAAGAATCACTTGAACCCGGGAGGCGGAGGTCCACTGCGCTCCAGCATGGGTGACAGACCGAGGCTCTGTCTCAAAAACAAATAGAGATGAGGTCTTGCTATGTTGTCCAGGCTAGTCTAGAAATCCAGGGCTAAAGCCATCTTCCCCCTTCAGCCTCTCTAGTAGCTGAGACTACAGGTTAGAACCACCAACCCAGACTTCTCCCTGTACATTTCAATAATTATTTCAAAACTTAAAAATCTGAAAGAAAGCAAACTGCTTGATAGTGGCAGAAAGCA...	GCGCACACCTGTAATCCCAAATAACTCGGGAGGCTGAGAAAGAAGAATCACTTGAACCCGGGAGGCGGAGGTCCACTGCGCTCCAGCATGGGTGACAGACCGAGGCTCTGTCTCAAAAACAAATAGAGATGAGGTCTTGCTATGTTGTCCAGGCTAGTCTAGAAATCCAGGGCTAAAGCCATCTTCCCCCTTCAGCCTCTCTAGTAGCTGAGACTACAGGTTAGAACCACCAACCCAGACTTCTCCCTGTACATTTCAATAATTATTTCAAAACTTAAAAATCTGAAAGAAAGCAAACTGCTTGATAGTGGCAGAAAGCA...
Task1_train_44201	A variant on Chromosome 16 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	AAGCCCCCTCCTCCATCAGGACCCAAAGGCCCAGGGCCTGCACCCAGGGTACAAGTCTCTTACAGGGTCTTGAAATGTCCGCACTGCAAAAGGGGCCCGGGCCCCCCACTTTCCATGAGACTTTAGGGTGCAGGGCAGAGAGGGGATGGTTTTAGGGTCGGTCAGCTGGATGTCAGTGCTCTCACTTCTCCCGGTTCCCCTGCCCTGAAGTGGAGGTGATAGGGGGACTGGAGCAGGCCTGCTGCACGGCTGTGTGTGGCCCAGCCTTAGGGCGGAGTCCAGGCTCCCAGGCCTGGCACAAACTCAGACCATACCATGTC...	AAGCCCCCTCCTCCATCAGGACCCAAAGGCCCAGGGCCTGCACCCAGGGTACAAGTCTCTTACAGGGTCTTGAAATGTCCGCACTGCAAAAGGGGCCCGGGCCCCCCACTTTCCATGAGACTTTAGGGTGCAGGGCAGAGAGGGGATGGTTTTAGGGTCGGTCAGCTGGATGTCAGTGCTCTCACTTCTCCCGGTTCCCCTGCCCTGAAGTGGAGGTGATAGGGGGACTGGAGCAGGCCTGCTGCACGGCTGTGTGTGGCCCAGCCTTAGGGCGGAGTCCAGGCTCCCAGGCCTGGCACAAACTCAGACCATACCATGTC...
Task1_train_44202	Consider this mutation on Chromosome 16. Is this a benign change or a disease-causing variant?	Benign	CACAACCGGTCGCACACAGGTAAGAGGCCGGGGCCGGGCGGCTTGGCCCATGAAGGGGGCGCTCAGCTGAGACCGGCTGGGCAGGTCCCCAGGGGGAGGGGACTGTTAAGTAAATCCCGGGCCTCAGAGATAAGGGTTGATGTCATCGCCCAGGGGTCCCTTTTCCAATGCAGTTTGCTAGGGGAAGCATCCCCTGGGGGTCAGACCCCCACCCAGCACCTGCTCTTGGAGCACCAATGCCATTTCCTGGTTCCCGTGGGTATCTTCTGACTAATGCCACCTCTGTGATCGCAGAGGCCAGGTCGGCTTCACTCCTCACT...	CACAACCGGTCGCACACAGGTAAGAGGCCGGGGCCGGGCGGCTTGGCCCATGAAGGGGGCGCTCAGCTGAGACCGGCTGGGCAGGTCCCCAGGGGGAGGGGACTGTTAAGTAAATCCCGGGCCTCAGAGATAAGGGTTGATGTCATCGCCCAGGGGTCCCTTTTCCAATGCAGTTTGCTAGGGGAAGCATCCCCTGGGGGTCAGACCCCCACCCAGCACCTGCTCTTGGAGCACCAATGCCATTTCCTGGTTCCCGTGGGTATCTTCTGACTAATGCCACCTCTGTGATCGCAGAGGCCAGGTCGGCTTCACTCCTCACT...
Task1_train_44203	Chromosome 16 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	CCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCTCGCCACTGCACTCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAGTAGATGAATGACTCTGCAGAGTTTTCCCAGGCCTGGCACTGCCCCTGGGGCTGCCATGTAGCCAGTGTCCCCACCTGAGCCCTGTGGCCCCCCAGCTCCAGCTCTGTCACCAGCCTCAGCTCCCCGCCTCCCTCCCTCACAGGGGACACCTGCCAATGCCTGTGGCCTCTGCCCCTCCTCCAGGAACCTTCCCGCCGGCCACTTCCTGGCGGCCCGCAGCCCC...	CCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCTCGCCACTGCACTCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAGTAGATGAATGACTCTGCAGAGTTTTCCCAGGCCTGGCACTGCCCCTGGGGCTGCCATGTAGCCAGTGTCCCCACCTGAGCCCTGTGGCCCCCCAGCTCCAGCTCTGTCACCAGCCTCAGCTCCCCGCCTCCCTCCCTCACAGGGGACACCTGCCAATGCCTGTGGCCTCTGCCCCTCCTCCAGGAACCTTCCCGCCGGCCACTTCCTGGCGGCCCGCAGCCCC...
Task1_train_44204	A mutation on Chromosome 16 is under review. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.	Benign	CGCTTTCTGGGCAAAGGCTTGGAGGTCAAAGAAAGCTACCTAGTGAGGATACCGTACACACCCACACTGCCTTGAGATGCAGACAGCCACCATCTACCAGGCCCAGGTCCCACATGACGAAGAGGTCAGCCAGCCTCACCAGCAAGTACGACCAGGGTGTGGCCAAAACCACCCTGCCTGGCTAGTTTCACTGCTTAAATGGGAGTCCTCTCGGTCTTCAGCTGGACAAAAGTGGAACTGACTGTACCGTTTGGACTAAAAAGCTGCAATCTTCCATGTGACTGGGTTTCTCTCCTGAGTCTTGTGTGTGTAGGGGGCTC...	CGCTTTCTGGGCAAAGGCTTGGAGGTCAAAGAAAGCTACCTAGTGAGGATACCGTACACACCCACACTGCCTTGAGATGCAGACAGCCACCATCTACCAGGCCCAGGTCCCACATGACGAAGAGGTCAGCCAGCCTCACCAGCAAGTACGACCAGGGTGTGGCCAAAACCACCCTGCCTGGCTAGTTTCACTGCTTAAATGGGAGTCCTCTCGGTCTTCAGCTGGACAAAAGTGGAACTGACTGTACCGTTTGGACTAAAAAGCTGCAATCTTCCATGTGACTGGGTTTCTCTCCTGAGTCTTGTGTGTGTAGGGGGCTC...
Task1_train_44205	A mutation has occurred on Chromosome 16. What is the medical relevance of this mutation?	Benign	CTTTTTTTTTTCTGTGATGGAGTTTCACTCCTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTTGGCTCACTGCAACCTCTGCCCCCCAGGTTCAAGCGATTCTCTTGCTTCAGCCTCCTTACTAGCTGGGATTACAGGCATGTACCACCACATCCGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCTAACTCCTGACCTCAGGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCAGGAGCCACCATACCCGGCCCGGCTTATTCACTTTTTAAACAGAT...	CTTTTTTTTTTCTGTGATGGAGTTTCACTCCTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTTGGCTCACTGCAACCTCTGCCCCCCAGGTTCAAGCGATTCTCTTGCTTCAGCCTCCTTACTAGCTGGGATTACAGGCATGTACCACCACATCCGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCTAACTCCTGACCTCAGGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCAGGAGCCACCATACCCGGCCCGGCTTATTCACTTTTTAAACAGAT...
Task1_train_44206	A mutation on Chromosome 16 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	TGCCTGGCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTTGCTGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTTAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCATAAACTACCACGCCTGGCCTCCAAGACTCTGGAGAGAGGGTGACATTGCTGACACCTTGATTTTGAACTTCTAGCTTCTAGAATATCAGAGAATCGATTTCTGTGGTTTTTGTTTTTGTTTTTGAGACAGAGTCTAGCTCTGTCGCTCAGGCCGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCGCCT...	TGCCTGGCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTTGCTGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTTAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCATAAACTACCACGCCTGGCCTCCAAGACTCTGGAGAGAGGGTGACATTGCTGACACCTTGATTTTGAACTTCTAGCTTCTAGAATATCAGAGAATCGATTTCTGTGGTTTTTGTTTTTGTTTTTGAGACAGAGTCTAGCTCTGTCGCTCAGGCCGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCGCCT...
Task1_train_44207	A mutation is present on Chromosome 16. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	GCTGGGATTACAAGCATAAACTACCACGCCTGGCCTCCAAGACTCTGGAGAGAGGGTGACATTGCTGACACCTTGATTTTGAACTTCTAGCTTCTAGAATATCAGAGAATCGATTTCTGTGGTTTTTGTTTTTGTTTTTGAGACAGAGTCTAGCTCTGTCGCTCAGGCCGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCGCCTCTTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCAC...	GCTGGGATTACAAGCATAAACTACCACGCCTGGCCTCCAAGACTCTGGAGAGAGGGTGACATTGCTGACACCTTGATTTTGAACTTCTAGCTTCTAGAATATCAGAGAATCGATTTCTGTGGTTTTTGTTTTTGTTTTTGAGACAGAGTCTAGCTCTGTCGCTCAGGCCGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCGCCTCTTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCAC...
Task1_train_44208	A mutation located on Chromosome 16 is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.	Benign	GTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAAACCCCCGTCTCCACTAAAAATACAAAAATTAGCTGGGTGTGGTTGCAGGCACCCGTAACCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCACTTGAACCCAGGAGGTGGAGATTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGGTGGGGTCGGTGGGGCGGCATGGTGGTTCACGCCTGTAATCTCAGCATTTTGGGAGGCTGAGGTGGGCAGATCACAAGGTCAGGA...	GTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAAACCCCCGTCTCCACTAAAAATACAAAAATTAGCTGGGTGTGGTTGCAGGCACCCGTAACCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCACTTGAACCCAGGAGGTGGAGATTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGGTGGGGTCGGTGGGGCGGCATGGTGGTTCACGCCTGTAATCTCAGCATTTTGGGAGGCTGAGGTGGGCAGATCACAAGGTCAGGA...
Task1_train_44209	Here is a mutation located on Chromosome 16. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?	Benign	AGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGGTGGGGTCGGTGGGGCGGCATGGTGGTTCACGCCTGTAATCTCAGCATTTTGGGAGGCTGAGGTGGGCAGATCACAAGGTCAGGAGATCGAGACCATCCTCGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCTGGATGTGGTGGCAGGTACCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAAGTGGAGCTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGTGA...	AGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGGTGGGGTCGGTGGGGCGGCATGGTGGTTCACGCCTGTAATCTCAGCATTTTGGGAGGCTGAGGTGGGCAGATCACAAGGTCAGGAGATCGAGACCATCCTCGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCTGGATGTGGTGGCAGGTACCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAAGTGGAGCTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGTGA...
Task1_train_44210	Consider this mutation on Chromosome 16. Is this a benign change or a disease-causing variant?	Benign	CCAGGCAGGATCACAACGGTGGCTAATATTTAATGAACCCCGACTTCGTGCCAGGCCCTGCCCCACCTCCTTCACCCTCCAACAACCTGCCAAGGAGTTTCACAAATGACCAGCTGAGTGAGGGCTGCTTGCCGGGCGGCCAGGGCAGATGGAGTCCACATCTGATGCACCCAGTCCTGTCCCCACTCATTCACTGGCCTCCCCAAGGGCTGTCATCTAGAGGGAGGGGCTTTCCCCCTTGGCTCATTCATTCCCAAGACCCACACAGCAAGCCAGGACTTGAATCATGATGGCGTCAACTGCTTCATCTTTTTTTTTTT...	CCAGGCAGGATCACAACGGTGGCTAATATTTAATGAACCCCGACTTCGTGCCAGGCCCTGCCCCACCTCCTTCACCCTCCAACAACCTGCCAAGGAGTTTCACAAATGACCAGCTGAGTGAGGGCTGCTTGCCGGGCGGCCAGGGCAGATGGAGTCCACATCTGATGCACCCAGTCCTGTCCCCACTCATTCACTGGCCTCCCCAAGGGCTGTCATCTAGAGGGAGGGGCTTTCCCCCTTGGCTCATTCATTCCCAAGACCCACACAGCAAGCCAGGACTTGAATCATGATGGCGTCAACTGCTTCATCTTTTTTTTTTT...
Task1_train_44211	A mutation located on Chromosome 16 is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.	Benign	CAGAGTGGGTGTTGCCCTTGAGGAGCTGTGAGCTGAGTCCCGTGGGGGTGTTGCAGAGGCCCCAGTCTCCCTTCTGCCCCAAGTCCAAGCCCACTCTTGGGGAGCTGTGAGGCTGAGGGTGCATTCTCCCAAAGCTGCTCCAGCTCATCCCAGGCAGCCTCGGGTTGCCAGTCTCCTAAGTGACCCAACATCTGTGCCCCCTTTGCTGGCAGCACTCCGCCCCATCCTTGTCCCCTGCCTCGTCCTCTGCCCCTTGCAAGCTTCCCTGGCTCTGTCTGCCCTCTGCCCAGAGGCCCTGCCCTACCCAGTGTGTGCTGGAG...	CAGAGTGGGTGTTGCCCTTGAGGAGCTGTGAGCTGAGTCCCGTGGGGGTGTTGCAGAGGCCCCAGTCTCCCTTCTGCCCCAAGTCCAAGCCCACTCTTGGGGAGCTGTGAGGCTGAGGGTGCATTCTCCCAAAGCTGCTCCAGCTCATCCCAGGCAGCCTCGGGTTGCCAGTCTCCTAAGTGACCCAACATCTGTGCCCCCTTTGCTGGCAGCACTCCGCCCCATCCTTGTCCCCTGCCTCGTCCTCTGCCCCTTGCAAGCTTCCCTGGCTCTGTCTGCCCTCTGCCCAGAGGCCCTGCCCTACCCAGTGTGTGCTGGAG...
Task1_train_44212	A mutation on Chromosome 16 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	AGTGGGAGTTTGCCCCAACCCCGGGCTGAGGGCCAGAGCGGCCCTTCTGGACGCACGTGATGCCAATTTCCTTCAGGTCGCTCTCAGTGAGGGTCAGAAAGATGCGGAGGTCCACGTCCTGCTCCTCAAACACCTGCAGGTACTTCAGACACCCGATCTGCTCCAGCAGTGCGGCAAGGTCCTGGCAGGCACAGGGGACAGGTTGGGGGAGGTAGTGGCTGACGACGAAGCAGAGACGTTTTCCTCCACTCGGAGCCCCACCACTTCCCCAGGCTCAGAACCAAGACAGTGCCTTGTGTGTGGCGCCCAGGCTGTCCCCT...	AGTGGGAGTTTGCCCCAACCCCGGGCTGAGGGCCAGAGCGGCCCTTCTGGACGCACGTGATGCCAATTTCCTTCAGGTCGCTCTCAGTGAGGGTCAGAAAGATGCGGAGGTCCACGTCCTGCTCCTCAAACACCTGCAGGTACTTCAGACACCCGATCTGCTCCAGCAGTGCGGCAAGGTCCTGGCAGGCACAGGGGACAGGTTGGGGGAGGTAGTGGCTGACGACGAAGCAGAGACGTTTTCCTCCACTCGGAGCCCCACCACTTCCCCAGGCTCAGAACCAAGACAGTGCCTTGTGTGTGGCGCCCAGGCTGTCCCCT...
Task1_train_44213	A variant on Chromosome 16 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	CAGCAAAGCCAGTGCTTTAACAAATAACCAGCCAGGCCGGGCATGGCACCAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGCGGGCGGATCACGATGTCAGGAATTTGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACTAAAAATACAAAAAATTAGATGGGCATGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGAGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCCAGATGACAGTGCG...	CAGCAAAGCCAGTGCTTTAACAAATAACCAGCCAGGCCGGGCATGGCACCAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGCGGGCGGATCACGATGTCAGGAATTTGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACTAAAAATACAAAAAATTAGATGGGCATGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGAGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCCAGATGACAGTGCG...
Task1_train_44214	Consider a variant on Chromosome 16. Determine its clinical classification and disease relevance.	Benign	CTGTGTCTCTGTGTAGGGGTGGAAGGGCAACAGCCACCTGTCCTGCCACAGGGAGAAAGGCAAGCTGCAGTGAAGCTGGGAGAGGCAGAGGTGGAGGCAGGGCCCCAGGGTCCCGTAAGGCCCCTCTATATGCCTGCCCTCCCCACACTTTGGTTGCTCCGCACTTGAGGAATCTGAGAACCAGTGAATCCCTTTTCACCTGACCAGCAGTGGGTTTCTGTGTCTGGAAACCAAAAGTACCTAACAGAAGTGGCTACACCTGGCTGGGCGCGGTGGCTCATGCCTATAATCCCGGCACTTTGGAAGGCCGAGGCAGGCAG...	CTGTGTCTCTGTGTAGGGGTGGAAGGGCAACAGCCACCTGTCCTGCCACAGGGAGAAAGGCAAGCTGCAGTGAAGCTGGGAGAGGCAGAGGTGGAGGCAGGGCCCCAGGGTCCCGTAAGGCCCCTCTATATGCCTGCCCTCCCCACACTTTGGTTGCTCCGCACTTGAGGAATCTGAGAACCAGTGAATCCCTTTTCACCTGACCAGCAGTGGGTTTCTGTGTCTGGAAACCAAAAGTACCTAACAGAAGTGGCTACACCTGGCTGGGCGCGGTGGCTCATGCCTATAATCCCGGCACTTTGGAAGGCCGAGGCAGGCAG...
Task1_train_44215	A mutation on Chromosome 16 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	GCCCAGGGAGCTGCACCGCCACTGCCCCTCGAGGCTGGCGCCAAGCCTGGTGGTGCAGCTGGTCTTCTCCACTCTCGTTGCAGTGGTGAGTCCTGGTGTCTCCGCCCACTGCTCCCATGTGCCACTGCTGCAGAGCTGGGACACCACCGGAGAAGGGACAGATTCGCCACGAGGAGTGGTGGACCCACTGCACACTCAGCCACCGAGGCCCATGCTCCACAGGGAGACAAGAGCATCCCCTGGCTCCGTGGCTAGCCAGCCCCAGGACCCCATTGCGGCAGACGGGGGACTTCAGGATGCCTCTGGGCCAGTGGCTCCCA...	GCCCAGGGAGCTGCACCGCCACTGCCCCTCGAGGCTGGCGCCAAGCCTGGTGGTGCAGCTGGTCTTCTCCACTCTCGTTGCAGTGGTGAGTCCTGGTGTCTCCGCCCACTGCTCCCATGTGCCACTGCTGCAGAGCTGGGACACCACCGGAGAAGGGACAGATTCGCCACGAGGAGTGGTGGACCCACTGCACACTCAGCCACCGAGGCCCATGCTCCACAGGGAGACAAGAGCATCCCCTGGCTCCGTGGCTAGCCAGCCCCAGGACCCCATTGCGGCAGACGGGGGACTTCAGGATGCCTCTGGGCCAGTGGCTCCCA...
Task1_train_44216	This sequence variant lies on Chromosome 16. Is it clinically significant, and what condition might it cause if any?	Benign	TCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCGCCACCACAGCGGGGTAATTTTTGTATTATTATTATTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGAGATCTCGGCTCACTGCAATCTCTGCCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGTTGGGACTATAGGCGCGTGCCACCATGGCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCGTGTTACCCAGGATGGTCTTGATCTCCTGA...	TCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCGCCACCACAGCGGGGTAATTTTTGTATTATTATTATTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGAGATCTCGGCTCACTGCAATCTCTGCCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGTTGGGACTATAGGCGCGTGCCACCATGGCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCGTGTTACCCAGGATGGTCTTGATCTCCTGA...
Task1_train_44217	This sequence change occurs on Chromosome 16. What is the medical significance of this variant — is it benign or linked to a disease?	Benign	ACCACAGCGGGGTAATTTTTGTATTATTATTATTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGAGATCTCGGCTCACTGCAATCTCTGCCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGTTGGGACTATAGGCGCGTGCCACCATGGCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCGTGTTACCCAGGATGGTCTTGATCTCCTGACCTTGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGACCA...	ACCACAGCGGGGTAATTTTTGTATTATTATTATTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGAGATCTCGGCTCACTGCAATCTCTGCCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGTTGGGACTATAGGCGCGTGCCACCATGGCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCGTGTTACCCAGGATGGTCTTGATCTCCTGACCTTGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGACCA...
Task1_train_44218	A variant was discovered on Chromosome 16. Please indicate if this mutation results in a known disease or if it's non-harmful.	Benign	TTCTCTGCCCATAAACACCCGGGTCCCAGGCCCTCCTTCCTTTCCCTTTGGTGCTCCCTCCTCCCCACGTACCATTGCGCGTGCAGCTGGAGCAGAATACCCTCATTTTTAGGAATCTAGTGATGCCTCTTGCCTCAGGGAAACGTTTCTTTGATGGGGAGTTTGAGATTTCTTTTCCTTGTTTATGCTTTATTTGTGGTAATGAAAGAGCGAATGACTGAACAGCCATGGCAAGGCAGACCTACAGGCGAGGCCGCAGCAGAGGGTGGGGCAGAGCAGCCTCGGGGTCTGGGGGCTGCAGGGGTTTCCCTGGCGCAGCG...	TTCTCTGCCCATAAACACCCGGGTCCCAGGCCCTCCTTCCTTTCCCTTTGGTGCTCCCTCCTCCCCACGTACCATTGCGCGTGCAGCTGGAGCAGAATACCCTCATTTTTAGGAATCTAGTGATGCCTCTTGCCTCAGGGAAACGTTTCTTTGATGGGGAGTTTGAGATTTCTTTTCCTTGTTTATGCTTTATTTGTGGTAATGAAAGAGCGAATGACTGAACAGCCATGGCAAGGCAGACCTACAGGCGAGGCCGCAGCAGAGGGTGGGGCAGAGCAGCCTCGGGGTCTGGGGGCTGCAGGGGTTTCCCTGGCGCAGCG...
Task1_train_44219	A variant was discovered on Chromosome 16. Please indicate if this mutation results in a known disease or if it's non-harmful.	Benign	TTCTGAGTTTCACGAACATGTTCCAGTCAATGAGCCCGGCACGGTGGGCTTCCTCCGGGGACAGCTCGCGGCCTGTGTCAGGGTGGATGACTACGATGGAGCGCCGCAGGTGGTTCTCCCGCTGCTCCCGCTTGACGGCCACGGAGCCCAGGCGCTTCTGCAGCTCGTCGATCTCGAGGTCTTTGTCCTTGGAGAGCCTCTTGAGGTCATCCAGTTCCCTCTCCAGGGACCACAGTCTGGAGTCATGGTTGGTCCCAGAGTCCGCCACGGTCATGTTCCGCAGGTCTCGTGTTTCCGTCGCTGCCATGTTGATTTCCGAT...	TTCTGAGTTTCACGAACATGTTCCAGTCAATGAGCCCGGCACGGTGGGCTTCCTCCGGGGACAGCTCGCGGCCTGTGTCAGGGTGGATGACTACGATGGAGCGCCGCAGGTGGTTCTCCCGCTGCTCCCGCTTGACGGCCACGGAGCCCAGGCGCTTCTGCAGCTCGTCGATCTCGAGGTCTTTGTCCTTGGAGAGCCTCTTGAGGTCATCCAGTTCCCTCTCCAGGGACCACAGTCTGGAGTCATGGTTGGTCCCAGAGTCCGCCACGGTCATGTTCCGCAGGTCTCGTGTTTCCGTCGCTGCCATGTTGATTTCCGAT...
Task1_train_44220	A mutation found on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	CAGGGAGGACACAGCTGTGGCAGGCCTCTGCCCTGCTCCACCTCCCAAAGGCTTGGCTCCCCAGAAAGGGGCTTGTTGACCTCTGACCCTCCCTTGCCAGTGTGTGCCTGGGGCTGCGGAAACGGCCATCTCACCTTCTGGTTCTTCAGCTTGGTCTCCATCTGGCTGAGGCTGTCTGTCTCCTGGGGCTCGTAACTGGGGATGCTGACTAGGAACTGCAGCACGTGGTCATGGCCGCGGTGGAAGTGCTCGTAGGCTGCCTTGGCGCTCTGTAGGCTCTGCGCCCTGTCAAGGCAAAGCGTTCAGGCCTCAGCCACAGC...	CAGGGAGGACACAGCTGTGGCAGGCCTCTGCCCTGCTCCACCTCCCAAAGGCTTGGCTCCCCAGAAAGGGGCTTGTTGACCTCTGACCCTCCCTTGCCAGTGTGTGCCTGGGGCTGCGGAAACGGCCATCTCACCTTCTGGTTCTTCAGCTTGGTCTCCATCTGGCTGAGGCTGTCTGTCTCCTGGGGCTCGTAACTGGGGATGCTGACTAGGAACTGCAGCACGTGGTCATGGCCGCGGTGGAAGTGCTCGTAGGCTGCCTTGGCGCTCTGTAGGCTCTGCGCCCTGTCAAGGCAAAGCGTTCAGGCCTCAGCCACAGC...
Task1_train_44221	A mutation found on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	GCTGTGAGGACAGAAATGAGCTGGGAACCTGGGCAGCCCACCACCCCCTGCACCCACAGAGGCGGGACTGCGGACTCTGGCTGGGCAGACACCCCAGAGGAGCCTGACAGCTCCTTAGATGCGGACAGCAAGTGCTCACTGTGGCACTGGCCTTTCTGTGCTCCTGGGCTCAGAGCTCTTCTCCCTCCTTCCCTCCTCTTTCGTAGGAAGTCTCACTACCTAAAATTGTCTGTCCAATAATCACCACCAAGATGTTACTTCTGAGGGAGCATACACAGTAGGTGCTCAATAAATACTTAATAAATGAAGGCATTCCTTGA...	GCTGTGAGGACAGAAATGAGCTGGGAACCTGGGCAGCCCACCACCCCCTGCACCCACAGAGGCGGGACTGCGGACTCTGGCTGGGCAGACACCCCAGAGGAGCCTGACAGCTCCTTAGATGCGGACAGCAAGTGCTCACTGTGGCACTGGCCTTTCTGTGCTCCTGGGCTCAGAGCTCTTCTCCCTCCTTCCCTCCTCTTTCGTAGGAAGTCTCACTACCTAAAATTGTCTGTCCAATAATCACCACCAAGATGTTACTTCTGAGGGAGCATACACAGTAGGTGCTCAATAAATACTTAATAAATGAAGGCATTCCTTGA...
Task1_train_44222	Chromosome 16 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	CAACAGAGATGTCCCCTCAGAGGTCATGGTTCTCAGGCCAAGGGTCATTTCAGGATGGTCATCATGGCCATCATCGTGGCCGTGGCGTCAGACTGAGAGTGATCCCTGTAGATTCCAGGATCTGCAGCCAGGCTTGGGAACTGCTCTTAGGAATACACCTGAATGACTCTAAGGCGCCTGACTTTGCAGCTCCTTTTTAAGAGGCAGAGCCCGTTTCCCTTCTCCCTGAATCTGAGCTGGCCTGGTGACTTGTGCAGGCGCCCACCAGGGCTGCCAGATCTTTAAAGAGAAACCAGCAAGCTGGAATTTTTGTCAATCTC...	CAACAGAGATGTCCCCTCAGAGGTCATGGTTCTCAGGCCAAGGGTCATTTCAGGATGGTCATCATGGCCATCATCGTGGCCGTGGCGTCAGACTGAGAGTGATCCCTGTAGATTCCAGGATCTGCAGCCAGGCTTGGGAACTGCTCTTAGGAATACACCTGAATGACTCTAAGGCGCCTGACTTTGCAGCTCCTTTTTAAGAGGCAGAGCCCGTTTCCCTTCTCCCTGAATCTGAGCTGGCCTGGTGACTTGTGCAGGCGCCCACCAGGGCTGCCAGATCTTTAAAGAGAAACCAGCAAGCTGGAATTTTTGTCAATCTC...
Task1_train_44223	This variant lies on Chromosome 16. Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?	Benign	AATGCGTGTAAAGAGGTTTGCAGCCCCGGGACCGGGTTTTCAGCTGGTTTTTCTACCCCAAAGTCCAATGCGTGCAGGCTGTCATCAGCACCACAGACAGCACCAGAACCCATCATAATGTCCCAGAAGGTTTTATTGCTAAATTAGTGTCAGAGCTCCAGGGAACACATTCAGATATAGTCACACTGAGTCAGAGCTCGAGGGAAGAGCTGTAAGCTGGGAACCAGAGAACCGATGACAAGGCAGCGGCCTCTTCTGGCAGCTTCCGGAGGAGCCCCCACTTAATGGGACGTCATCACTTGAGGCAGCAGGTAACGTTT...	AATGCGTGTAAAGAGGTTTGCAGCCCCGGGACCGGGTTTTCAGCTGGTTTTTCTACCCCAAAGTCCAATGCGTGCAGGCTGTCATCAGCACCACAGACAGCACCAGAACCCATCATAATGTCCCAGAAGGTTTTATTGCTAAATTAGTGTCAGAGCTCCAGGGAACACATTCAGATATAGTCACACTGAGTCAGAGCTCGAGGGAAGAGCTGTAAGCTGGGAACCAGAGAACCGATGACAAGGCAGCGGCCTCTTCTGGCAGCTTCCGGAGGAGCCCCCACTTAATGGGACGTCATCACTTGAGGCAGCAGGTAACGTTT...
Task1_train_44224	A genomic change on Chromosome 16 is noted. Classify this variant as benign or pathogenic, and name the disease if relevant.	Benign	CTGGAGGTGTTCCAGGAAAGGCCTTGGGCTCTGGAATTTCTGTGGCTTCCGCTCCAGTCCCTAGGACAGTCCTCGTGTTGGGCTCTGGGGACGGGCAGCTGACCAGGTAGTACACAGCAGGCCCCTACCACCCTAGCCATAGGCAGCCCCAGCCCCTCTGTGTCATAAAGGCCTAGCTAGGGTAGGACCTCTGGAAGTCTCCTGGGAACTTCTCTCCCTTCTCCTGCGTGACTTTTGGTGGCAGCTACGAAACTGACTCACTGGATTTCTGCTTTCACTCTCTCCTGTCCACCTGTAGGTGGATGATGAGGCCACAGTGG...	CTGGAGGTGTTCCAGGAAAGGCCTTGGGCTCTGGAATTTCTGTGGCTTCCGCTCCAGTCCCTAGGACAGTCCTCGTGTTGGGCTCTGGGGACGGGCAGCTGACCAGGTAGTACACAGCAGGCCCCTACCACCCTAGCCATAGGCAGCCCCAGCCCCTCTGTGTCATAAAGGCCTAGCTAGGGTAGGACCTCTGGAAGTCTCCTGGGAACTTCTCTCCCTTCTCCTGCGTGACTTTTGGTGGCAGCTACGAAACTGACTCACTGGATTTCTGCTTTCACTCTCTCCTGTCCACCTGTAGGTGGATGATGAGGCCACAGTGG...
Task1_train_44225	Given this context: Chromosome 16 — does this variant present pathogenic behavior, and if so, what disease does it relate to?	Benign	GTGAGGCCTTCATTGTATTTCTTCCTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTATGTCCCAGACTGGAGTGCAATGGCGCCATCTCGGCTCACTGCAGCCTCCGCCTTCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCCACCACCACGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAACGATCCACCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTGT...	GTGAGGCCTTCATTGTATTTCTTCCTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTATGTCCCAGACTGGAGTGCAATGGCGCCATCTCGGCTCACTGCAGCCTCCGCCTTCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCCACCACCACGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAACGATCCACCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTGT...
Task1_train_44226	An alteration has been detected on Chromosome 16. Is it pathogenic, and if so, what disease is involved?	Benign	GAGGGGGAAGCAGTGCAGAGGGAGCTGCCCACAGTGAGGCCCTGCCCCTCGGTCAGTCCGGCACACACTGGAGGCCATGAGGAGGAGCCCTGCGGTTACTGTGGCTGGGCTGAGCCTCACTGAAGTAGTTGCTTCCATTTAGAGCTCATGTTATATTTAGGTTGGTACAAAAGTAATCATGGTTTTTGCCATTAAAAATGGCAACTACTTTTGCACCAACCCAATATGAAAACAAAAAGCACCTTAAATACCAGAACTCCACTCGGGGCTTTTGCTCCTAGGGTAGAATTGGTGGGAATTGCCTGCAGGCTTACATGGTT...	GAGGGGGAAGCAGTGCAGAGGGAGCTGCCCACAGTGAGGCCCTGCCCCTCGGTCAGTCCGGCACACACTGGAGGCCATGAGGAGGAGCCCTGCGGTTACTGTGGCTGGGCTGAGCCTCACTGAAGTAGTTGCTTCCATTTAGAGCTCATGTTATATTTAGGTTGGTACAAAAGTAATCATGGTTTTTGCCATTAAAAATGGCAACTACTTTTGCACCAACCCAATATGAAAACAAAAAGCACCTTAAATACCAGAACTCCACTCGGGGCTTTTGCTCCTAGGGTAGAATTGGTGGGAATTGCCTGCAGGCTTACATGGTT...
Task1_train_44227	Consider a variant on Chromosome 16. Determine its clinical classification and disease relevance.	Benign	TGAGAGCCAGGTGGCTGGGGTGCAGTCTGCGGGAGCTCGGGGGTCTCTTGGCCTCCGTGTGTCCTAGTGTCTTTGTTGGTGAGATGGGACAGTGACAGCACACCCTCACAGTTGCTGGGGGCTGACAAATGTCAGGTCTGAGGACAGTTGCTGGCCCACTATGGGGCCAGTTCCCCTTCTCTACAGTCACCCTGCTCGTCTTCCACCGACTGGGTGCTCAGGACAGTGGCGTGGTGGATCCGCCTGTACATCCTGTGCTCCAGCGTCCTGCAGGCCACAGCTGTGTCCAGCCCTGACCCCGACTGCCCCTCCCGCCACCT...	TGAGAGCCAGGTGGCTGGGGTGCAGTCTGCGGGAGCTCGGGGGTCTCTTGGCCTCCGTGTGTCCTAGTGTCTTTGTTGGTGAGATGGGACAGTGACAGCACACCCTCACAGTTGCTGGGGGCTGACAAATGTCAGGTCTGAGGACAGTTGCTGGCCCACTATGGGGCCAGTTCCCCTTCTCTACAGTCACCCTGCTCGTCTTCCACCGACTGGGTGCTCAGGACAGTGGCGTGGTGGATCCGCCTGTACATCCTGTGCTCCAGCGTCCTGCAGGCCACAGCTGTGTCCAGCCCTGACCCCGACTGCCCCTCCCGCCACCT...
Task1_train_44228	A variant was discovered on Chromosome 16. What is its functional impact — neutral or pathogenic? State the disease if pathogenic.	Benign	GTCTTAAATAGAAAACGAAAGCGCTGGAGCTGTCAGAGGTGCTGACACCCACCTGCAGTGCTGACTCAATGGTTTTGTTTTTTGAACAGGGGTGTTTTTAAAGGGTACAAGCACACCTGCAGTTCTTCTCTCAGGTCTTCTGGAGAGATTCAGGAGGCAGGGTCATGAGTCCCAGGGACTCTGGGATTCTTACCTTGTGCAAAATATCCCGCAGCAGCTCAGAATCTGATGAGTCTCTTAACTTTGCTTCTAAGCTCTGTGTGGAGGGGAAAGAGAGAAATCTCAAGGGCGCATTCACAGGAACATTAAACACGCAATAG...	GTCTTAAATAGAAAACGAAAGCGCTGGAGCTGTCAGAGGTGCTGACACCCACCTGCAGTGCTGACTCAATGGTTTTGTTTTTTGAACAGGGGTGTTTTTAAAGGGTACAAGCACACCTGCAGTTCTTCTCTCAGGTCTTCTGGAGAGATTCAGGAGGCAGGGTCATGAGTCCCAGGGACTCTGGGATTCTTACCTTGTGCAAAATATCCCGCAGCAGCTCAGAATCTGATGAGTCTCTTAACTTTGCTTCTAAGCTCTGTGTGGAGGGGAAAGAGAGAAATCTCAAGGGCGCATTCACAGGAACATTAAACACGCAATAG...
Task1_train_44229	A variant affecting Chromosome 16 has been observed. Determine if it's benign or associated with disease.	Benign	CGGGCATGAACCACCGCATCCAACCCTGTCCTCTACTCTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGTCTCGCTCCCTCACCCAGGCTGGAGTGCAGTGGCATGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTTGTATTTTTGGTAGACACAGGGTTTCACCGTGTTAACCAGAATGGTCTTGATCTCCTGACCTCGTGCCGCCCGCCTCGGCCTCCCAAAGTGTCCTCTGCTCTTT...	CGGGCATGAACCACCGCATCCAACCCTGTCCTCTACTCTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGTCTCGCTCCCTCACCCAGGCTGGAGTGCAGTGGCATGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTTGTATTTTTGGTAGACACAGGGTTTCACCGTGTTAACCAGAATGGTCTTGATCTCCTGACCTCGTGCCGCCCGCCTCGGCCTCCCAAAGTGTCCTCTGCTCTTT...
Task1_train_44230	A variant affecting Chromosome 16 has been observed. Determine if it's benign or associated with disease.	Benign	TTCATCCTGGGAGGCTCTGCCCCAGGCTTTTTAAACCGTGTCCCTGGCATGGTTCAGATTCTACATCTCCCTTCCCCAAGCAGGCTGAAGAGCTAGAAAAGGCCGGGCACGGTGGCTCACACCTATGATCCCACTTTGGGAGGCCAAAGCAGTGTATCACTTGAGCCCAAGGGTTTGAAACCAGCCCTGGCAACATGCTGAGACCCTATCTCTACAAAAACTACAAAACTAAAAAAATTTAGCCTGGCATGGAGGCATGCACCTGTAGCCCCAGCTACTCGAGAGGCTTAGGTGGCAGGGTCACTTGAGCCTGGGAGGTG...	TTCATCCTGGGAGGCTCTGCCCCAGGCTTTTTAAACCGTGTCCCTGGCATGGTTCAGATTCTACATCTCCCTTCCCCAAGCAGGCTGAAGAGCTAGAAAAGGCCGGGCACGGTGGCTCACACCTATGATCCCACTTTGGGAGGCCAAAGCAGTGTATCACTTGAGCCCAAGGGTTTGAAACCAGCCCTGGCAACATGCTGAGACCCTATCTCTACAAAAACTACAAAACTAAAAAAATTTAGCCTGGCATGGAGGCATGCACCTGTAGCCCCAGCTACTCGAGAGGCTTAGGTGGCAGGGTCACTTGAGCCTGGGAGGTG...
Task1_train_44231	This alteration occurs on Chromosome 16. Is it associated with a disease or is it a benign variant?	Benign	ACTGTTCTTACTCCTGTTGCATGTCTGGAATTTTTCTTGATAAAAAAATTTGGAAAGAAAAGGGAAAAAGGCAAAGAGCTTTAATTTCAAGTGAAACCATCTTGTAGACTAAGGTTTTGAAAGGCAAGTGGCAGGGTTGGGAGACCTGTTTCTGAAGGTGCTCACTCTCTGAAATCTCTCAGACCCCAGCTTCCCAGCAGTTTTCTCTCTGTTCTCTGTGCTCCCGGAGTCCTCTGCACCGCCCCCTGCCACTGCCTCTCATTCATTCATTTCTCAGATAGTTATGCGCAGCTCCAGGCACCAGATTCTGTGCTGGGTGC...	ACTGTTCTTACTCCTGTTGCATGTCTGGAATTTTTCTTGATAAAAAAATTTGGAAAGAAAAGGGAAAAAGGCAAAGAGCTTTAATTTCAAGTGAAACCATCTTGTAGACTAAGGTTTTGAAAGGCAAGTGGCAGGGTTGGGAGACCTGTTTCTGAAGGTGCTCACTCTCTGAAATCTCTCAGACCCCAGCTTCCCAGCAGTTTTCTCTCTGTTCTCTGTGCTCCCGGAGTCCTCTGCACCGCCCCCTGCCACTGCCTCTCATTCATTCATTTCTCAGATAGTTATGCGCAGCTCCAGGCACCAGATTCTGTGCTGGGTGC...
Task1_train_44232	Here’s a variant located on Chromosome 16. What is the predicted biological effect — harmless or disease-causing?	Benign	AGGCACGCTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATAACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGTTGGGCACAGTGGTGTGCCCCTGTAGTCCCAGCTACTTGTGAGGCTAAGAAGGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCTCTGTACTCTAGCCTGGGCAACAGAATGAGGAAAAAAAAAAAAAACGAACAAAAAAAACTTGGTATGATAATCATCCATCCT...	AGGCACGCTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATAACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGTTGGGCACAGTGGTGTGCCCCTGTAGTCCCAGCTACTTGTGAGGCTAAGAAGGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCTCTGTACTCTAGCCTGGGCAACAGAATGAGGAAAAAAAAAAAAAACGAACAAAAAAAACTTGGTATGATAATCATCCATCCT...
Task1_train_44233	A mutation found on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	ACGCTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATAACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGTTGGGCACAGTGGTGTGCCCCTGTAGTCCCAGCTACTTGTGAGGCTAAGAAGGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCTCTGTACTCTAGCCTGGGCAACAGAATGAGGAAAAAAAAAAAAAACGAACAAAAAAAACTTGGTATGATAATCATCCATCCTTCAC...	ACGCTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATAACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGTTGGGCACAGTGGTGTGCCCCTGTAGTCCCAGCTACTTGTGAGGCTAAGAAGGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCTCTGTACTCTAGCCTGGGCAACAGAATGAGGAAAAAAAAAAAAAACGAACAAAAAAAACTTGGTATGATAATCATCCATCCTTCAC...
Task1_train_44234	An alteration has been detected on Chromosome 16. Is it pathogenic, and if so, what disease is involved?	Benign	GAGGTTACAGTGAACTGTGACTGCACCACTGCACTCCCGCCTGGGCAATAGAGCGAGACTCTGTCTCTAAAAATAAAAATAGCAAAGAAGTAACAAGAGGTGGGATCTAACACCGGTTCTGTCTTTCCATTGGAAACCCAGAGCTCTTTCCATGACCCCTGCCCAGGGTGAATATTGTTTGTCTGAAGGAATCCAGGAGCCTTGTGGATTGGAGCTTATGCTGTGCCATTGTCTTTGGATGGATTGAAGGGTTTGACATGCCAGGGCTGGGACATGATGACAGTCTTATTCTGCCTGCCTCAGGCTTCAGGAAACAACTG...	GAGGTTACAGTGAACTGTGACTGCACCACTGCACTCCCGCCTGGGCAATAGAGCGAGACTCTGTCTCTAAAAATAAAAATAGCAAAGAAGTAACAAGAGGTGGGATCTAACACCGGTTCTGTCTTTCCATTGGAAACCCAGAGCTCTTTCCATGACCCCTGCCCAGGGTGAATATTGTTTGTCTGAAGGAATCCAGGAGCCTTGTGGATTGGAGCTTATGCTGTGCCATTGTCTTTGGATGGATTGAAGGGTTTGACATGCCAGGGCTGGGACATGATGACAGTCTTATTCTGCCTGCCTCAGGCTTCAGGAAACAACTG...
Task1_train_44235	This mutation occurs on Chromosome 16. Does this change lead to a known medical condition, or is it benign?	Benign	CCGGGAAATCAAACACCCTCTGTAAACTCATTACACATTATGTGGAAAATGTGAAATGCATTCAAACAAATGATGGGTGACCATGTATTAGTCTGTTCCCGCAATGCTACAAAAAAAAATACCTGGGATTGGGTAATTTTTAAAGAAAAGAGGTTTAATTGGCTCATGGTTCTGCAGGCTTTACAGGAAGCATGATGCTGGCATGTGCTCAGCTTCTGGGGAGGCCTCAGGAAACTTCCAATCATGGTGGAAGGCAAAGGGCAAGCGAGGTGCCTCACATGGTAGGAATAGGAGCAAGAGAGCAAGCAGGGAGGAGCCAC...	CCGGGAAATCAAACACCCTCTGTAAACTCATTACACATTATGTGGAAAATGTGAAATGCATTCAAACAAATGATGGGTGACCATGTATTAGTCTGTTCCCGCAATGCTACAAAAAAAAATACCTGGGATTGGGTAATTTTTAAAGAAAAGAGGTTTAATTGGCTCATGGTTCTGCAGGCTTTACAGGAAGCATGATGCTGGCATGTGCTCAGCTTCTGGGGAGGCCTCAGGAAACTTCCAATCATGGTGGAAGGCAAAGGGCAAGCGAGGTGCCTCACATGGTAGGAATAGGAGCAAGAGAGCAAGCAGGGAGGAGCCAC...
Task1_train_44236	A mutation has occurred on Chromosome 16. What is the medical relevance of this mutation?	Benign	ATGGATGAATAAAATGTGATCTAACAGCTGAGCACTATGCTCAGCTGCCTGTAATCCCAGCTACTCCAGAGGCTGAGGTGGATTGCTCAAGGACAGGAGTTCAAGACCTGCCTGGGCAGCATAGCACAGACACGACCTCTAAAAGTAATAATAAAATATATCTTCCATAAAATAAAATACTATTCAGCCATAAAATGAAATAAACTAGATTCATACTACAACTTGGATGAATCTTGAAAACATTATGCTAAGAGAAAAAGCCAGACACAAAAGGTCACATATGCTTCCACTTATAAGAAATATTCAGGTTACGCAAATTA...	ATGGATGAATAAAATGTGATCTAACAGCTGAGCACTATGCTCAGCTGCCTGTAATCCCAGCTACTCCAGAGGCTGAGGTGGATTGCTCAAGGACAGGAGTTCAAGACCTGCCTGGGCAGCATAGCACAGACACGACCTCTAAAAGTAATAATAAAATATATCTTCCATAAAATAAAATACTATTCAGCCATAAAATGAAATAAACTAGATTCATACTACAACTTGGATGAATCTTGAAAACATTATGCTAAGAGAAAAAGCCAGACACAAAAGGTCACATATGCTTCCACTTATAAGAAATATTCAGGTTACGCAAATTA...
Task1_train_44237	This is a variant located on Chromosome 16. Is this mutation a likely cause of disease or not?	Benign	CATGAAAAAATGCTCACCATCACTGGCCATCAGAGGAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCCTTGTGGAAGTCAGTGTGGCAATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTA...	CATGAAAAAATGCTCACCATCACTGGCCATCAGAGGAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCCTTGTGGAAGTCAGTGTGGCAATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTA...
Task1_train_44238	This alteration on Chromosome 16 may affect genome function. Does it lead to a disease or is it benign?	Benign	CATCACTGGCCATCAGAGGAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCCTTGTGGAAGTCAGTGTGGCAATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACA...	CATCACTGGCCATCAGAGGAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCCTTGTGGAAGTCAGTGTGGCAATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACA...
Task1_train_44239	Given this context: Chromosome 16 — does this variant present pathogenic behavior, and if so, what disease does it relate to?	Benign	TTCAAAGGCTCCCCATTGCTCTTAGGTAGGAATCCAAACCCTTCACCAGGCCTACCCAGACCCACCTGCCCCTTCCTCCAGCTTCATCCCGGACGCTTCCTTTGCCCTTGCTGCTCTCTCCGGAATCCTCTTCCCACCAACTTTTGGCCGCTCAACTCCCTGTTGATCTGTTCTCGGTGGCAACGTCCCCTGCTTCTCTGCTCCACCCAGTGTGGGTCCCATGAGAATATCTGGCTCACCCACCCTTGCTCCCTCCCTATAAAAATGTTGCAATGATTTCATGGAAACTCCTGTTTCGAGGCCAGTCATGGTGGCTCACG...	TTCAAAGGCTCCCCATTGCTCTTAGGTAGGAATCCAAACCCTTCACCAGGCCTACCCAGACCCACCTGCCCCTTCCTCCAGCTTCATCCCGGACGCTTCCTTTGCCCTTGCTGCTCTCTCCGGAATCCTCTTCCCACCAACTTTTGGCCGCTCAACTCCCTGTTGATCTGTTCTCGGTGGCAACGTCCCCTGCTTCTCTGCTCCACCCAGTGTGGGTCCCATGAGAATATCTGGCTCACCCACCCTTGCTCCCTCCCTATAAAAATGTTGCAATGATTTCATGGAAACTCCTGTTTCGAGGCCAGTCATGGTGGCTCACG...