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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_44500	A variant found on Chromosome 16 is being studied. Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?	Benign	CCAGCTGGAGTGGCAGTGGTATGACCTCGGCTCAGTCAACATTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGTGCACGCCACCAAGCCTGACTAATTTTTGTAGTTTTAGTAGAGAGGGGGTTTCACCAAGTTGGCCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCACCTGCTTCGGCCTCTGAAAGTGCTGGGATTGCAGGCGTGAGACACCGTGCCCGGCCAAGTGTGGGGCTCCTAATGAGAGCTGGCATACAGGTGTGGCGGGGACATGAGCTGCTCCCCT...	CCAGCTGGAGTGGCAGTGGTATGACCTCGGCTCAGTCAACATTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGTGCACGCCACCAAGCCTGACTAATTTTTGTAGTTTTAGTAGAGAGGGGGTTTCACCAAGTTGGCCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCACCTGCTTCGGCCTCTGAAAGTGCTGGGATTGCAGGCGTGAGACACCGTGCCCGGCCAAGTGTGGGGCTCCTAATGAGAGCTGGCATACAGGTGTGGCGGGGACATGAGCTGCTCCCCT...
Task1_train_44501	An alteration has been detected on Chromosome 16. Is it pathogenic, and if so, what disease is involved?	Benign	TTTTCAGTGTATTTGAGGTTATTTTTATTTATGCCTCTGTTTATGGCAAGCAATGCTGGTTTTCCATTTGAATAGTAATAAAGTTTTCCTGTTTAAATATACTTAATTAAATAAAAAAGAGAATCCACTGAAAGAAAAATAGTAAGCAAATAAAATTAGAATTGAGGCCGGGCACAGTGGCTCATGCCTGTACTCCCAGCACTTTGGGAGGCTGAGGTGGGCAAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCCGGAAAGGTGGTGCAC...	TTTTCAGTGTATTTGAGGTTATTTTTATTTATGCCTCTGTTTATGGCAAGCAATGCTGGTTTTCCATTTGAATAGTAATAAAGTTTTCCTGTTTAAATATACTTAATTAAATAAAAAAGAGAATCCACTGAAAGAAAAATAGTAAGCAAATAAAATTAGAATTGAGGCCGGGCACAGTGGCTCATGCCTGTACTCCCAGCACTTTGGGAGGCTGAGGTGGGCAAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCCGGAAAGGTGGTGCAC...
Task1_train_44502	A mutation is present on Chromosome 16. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	TCTTTAAAGCTTCTGGATTTTTAATTAAAATTATTAAGGCCTTTCCCATCCCAAGATTATAAAAGAATTTGCCCATGTTCACTTTTTACATTGGAATCTTTGGAGTTTTATTCTGTTGCAAAGGTAAGATGTGAATACTATTTTATCTTAGATTTTTTTTAAGTTGTCAAATTAAAAAAAAATTTTTTAAGAGAGTCTCGCTCTGTTGCCCATGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGATTCCAGTGATCCTCGTGCCTTAGCCTCCCTAGTAGCTGGGACTACAGTCGCGTGCC...	TCTTTAAAGCTTCTGGATTTTTAATTAAAATTATTAAGGCCTTTCCCATCCCAAGATTATAAAAGAATTTGCCCATGTTCACTTTTTACATTGGAATCTTTGGAGTTTTATTCTGTTGCAAAGGTAAGATGTGAATACTATTTTATCTTAGATTTTTTTTAAGTTGTCAAATTAAAAAAAAATTTTTTAAGAGAGTCTCGCTCTGTTGCCCATGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGATTCCAGTGATCCTCGTGCCTTAGCCTCCCTAGTAGCTGGGACTACAGTCGCGTGCC...
Task1_train_44503	Here is a genetic alteration on Chromosome 16. Based on the data, is it a benign variant or a cause of disease?	Benign	TTAAAGTACAGTGTGGGCCAAAGTTCTCCTATGACCTCTGACCACTGGTGAAGGAGACACCTCTTCTCCCTTTCTCTTGTTTCAACAGATGAATTTGACAACGCCCATTTTACACTCCTTGGGGTCCCCAACAAACCCCTGCAGTGTTTGGTGAGTGTCCTTTGCCCTGCCCTTGGGTTTGCTAAGGGGCACCAGCCCCAAGCACCTCTGGTCCTGGGATCTACACCCCGCGCACCTTCTCAGGTGCCTGCTTGGGACTCCCGCTCCCCACATCACCCCATCCGGGTTCACGACTTCGGGCGCCCCCTCGGTCCAATGCA...	TTAAAGTACAGTGTGGGCCAAAGTTCTCCTATGACCTCTGACCACTGGTGAAGGAGACACCTCTTCTCCCTTTCTCTTGTTTCAACAGATGAATTTGACAACGCCCATTTTACACTCCTTGGGGTCCCCAACAAACCCCTGCAGTGTTTGGTGAGTGTCCTTTGCCCTGCCCTTGGGTTTGCTAAGGGGCACCAGCCCCAAGCACCTCTGGTCCTGGGATCTACACCCCGCGCACCTTCTCAGGTGCCTGCTTGGGACTCCCGCTCCCCACATCACCCCATCCGGGTTCACGACTTCGGGCGCCCCCTCGGTCCAATGCA...
Task1_train_44504	A mutation is present on Chromosome 16. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	CCTAAATAACAGAAATTTATTTTTGCACAGTTCTGGAGGCTAGAAGTCCAAGATCAAGGTGACAGCATGGTTGATGTCTTTTTTTTTTTTTTTTTTTGGAGACAGAGTCTTACTCTGTCGCCCATGCTGGAGTGCAGTGGCGCAATCTCAGCTCCCTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTGCCTCAGTCTCCCAAGTGGCTGGGACTACATGTGTACAACACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCT...	CCTAAATAACAGAAATTTATTTTTGCACAGTTCTGGAGGCTAGAAGTCCAAGATCAAGGTGACAGCATGGTTGATGTCTTTTTTTTTTTTTTTTTTTGGAGACAGAGTCTTACTCTGTCGCCCATGCTGGAGTGCAGTGGCGCAATCTCAGCTCCCTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTGCCTCAGTCTCCCAAGTGGCTGGGACTACATGTGTACAACACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCT...
Task1_train_44505	A genomic variant on Chromosome 16 is under review. What is the biological outcome — benign or pathogenic?	Benign	ACCGCTACTGGCTCTTTCGAGAAGCGAACCTGGAGCCCGGCTACCCACAGCCGCTGACCAGCTATGGCCTGGGCATCCCCTATGACCGCATTGACACGGCCATCTGGTGGGAGCCCACAGGCCACACCTTCTTCTTCCAAGAGGACAGGTGAGCAGTGCGTCCCTCCCCTAAGGGGAGAAGGCCCCATCTAGGCCCCCCTCAACCTCAGGCCTACCCAGAAAGAATCCACTGCCTGTGGGGAACGGGTCCTGGCCCAAGCAGGATCTCTAGGTCCACAGCCTGGTGCTTTTGTTCACAGGTACTGGCGCTTCAACGAGGA...	ACCGCTACTGGCTCTTTCGAGAAGCGAACCTGGAGCCCGGCTACCCACAGCCGCTGACCAGCTATGGCCTGGGCATCCCCTATGACCGCATTGACACGGCCATCTGGTGGGAGCCCACAGGCCACACCTTCTTCTTCCAAGAGGACAGGTGAGCAGTGCGTCCCTCCCCTAAGGGGAGAAGGCCCCATCTAGGCCCCCCTCAACCTCAGGCCTACCCAGAAAGAATCCACTGCCTGTGGGGAACGGGTCCTGGCCCAAGCAGGATCTCTAGGTCCACAGCCTGGTGCTTTTGTTCACAGGTACTGGCGCTTCAACGAGGA...
Task1_train_44506	Assess the clinical impact of this variant found on Chromosome 16. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	GGACCGGGCCAAAGCCGAGGCAGTGAATAAGAGGCTCCGGAAGCAGCTGGCCGAGTTCCGGGCACCACAGGTGATGACTTACGTCCGGGAGAAGATCTTAAATGCGGACCTGGAGAAGAGCATCAGGATGTGGGAAAGGAAAGTGGAGATAGCAGAGGTGAGCCACGGGGAGCCCCAAGATGGGCAGTCTTTTATGTCTTCAACGTTTTCACTTAGGATTTTGTTCTTTGGGGTAAGAATACAGATGTTTGGATATGTAATTTCTGGGAGAAACCTCAGCAGTTGCTTTAACTATTAAACCAAGACGAAGGATGATTTGT...	GGACCGGGCCAAAGCCGAGGCAGTGAATAAGAGGCTCCGGAAGCAGCTGGCCGAGTTCCGGGCACCACAGGTGATGACTTACGTCCGGGAGAAGATCTTAAATGCGGACCTGGAGAAGAGCATCAGGATGTGGGAAAGGAAAGTGGAGATAGCAGAGGTGAGCCACGGGGAGCCCCAAGATGGGCAGTCTTTTATGTCTTCAACGTTTTCACTTAGGATTTTGTTCTTTGGGGTAAGAATACAGATGTTTGGATATGTAATTTCTGGGAGAAACCTCAGCAGTTGCTTTAACTATTAAACCAAGACGAAGGATGATTTGT...
Task1_train_44507	Chromosome 16 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	CGGGGAGCCCCAAGATGGGCAGTCTTTTATGTCTTCAACGTTTTCACTTAGGATTTTGTTCTTTGGGGTAAGAATACAGATGTTTGGATATGTAATTTCTGGGAGAAACCTCAGCAGTTGCTTTAACTATTAAACCAAGACGAAGGATGATTTGTTTTTTTTGAAAGTTCCCCCTTTTGCATTGTTAGGGGCAGAGTCTTTTCCATTTTCAGGGAGAAACTCTGTAGTAATAGTGTGTTTTTAGTTGCTTGTTATCTTAATGAATTCTAGAAGTTTCTGAATCCCTCTGCACTGGTAATTTAGTGATTGCTACTTTATAC...	CGGGGAGCCCCAAGATGGGCAGTCTTTTATGTCTTCAACGTTTTCACTTAGGATTTTGTTCTTTGGGGTAAGAATACAGATGTTTGGATATGTAATTTCTGGGAGAAACCTCAGCAGTTGCTTTAACTATTAAACCAAGACGAAGGATGATTTGTTTTTTTTGAAAGTTCCCCCTTTTGCATTGTTAGGGGCAGAGTCTTTTCCATTTTCAGGGAGAAACTCTGTAGTAATAGTGTGTTTTTAGTTGCTTGTTATCTTAATGAATTCTAGAAGTTTCTGAATCCCTCTGCACTGGTAATTTAGTGATTGCTACTTTATAC...
Task1_train_44508	Mutation context: Chromosome 16. Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.	Benign	CATAGGAGTTTTGTGTGACCTGGGCCCCGGATGCTGGGCCCCACAGATGCCACCTGAGTTGCAAGTTGGCCATCCCAGGCTGTGCCCAACTCCCCTTTGCCCTTAGGGAGGACTTGGCGCACTGTTCTGATGGCAGTGCTGGGCCTACTGGGGGAAGGGACTCTTCCTTCCGTGCTGGGGGTCCAGGGCCAGGGGCCGTGTCCTGCCAGGGAAGCCTGTCTGGGGGTGAGGCACACTCCCCTCACCCGCCCCAGGGCTTGGGGTCAGAGCTGGGTCTATGGCACCTGAGAAGGCCTTTTGAAACAACTCATGGCTGCACC...	CATAGGAGTTTTGTGTGACCTGGGCCCCGGATGCTGGGCCCCACAGATGCCACCTGAGTTGCAAGTTGGCCATCCCAGGCTGTGCCCAACTCCCCTTTGCCCTTAGGGAGGACTTGGCGCACTGTTCTGATGGCAGTGCTGGGCCTACTGGGGGAAGGGACTCTTCCTTCCGTGCTGGGGGTCCAGGGCCAGGGGCCGTGTCCTGCCAGGGAAGCCTGTCTGGGGGTGAGGCACACTCCCCTCACCCGCCCCAGGGCTTGGGGTCAGAGCTGGGTCTATGGCACCTGAGAAGGCCTTTTGAAACAACTCATGGCTGCACC...
Task1_train_44509	This mutation occurs on Chromosome 16. Does this change lead to a known medical condition, or is it benign?	Benign	TTTATGGGAGCCTTGGAGAGAGCGGAGCATGGCCCCTGCACTTACAGACGGGGAAGCCTAGAATCCCACAGCCTTTCAGACACCGAGACAGGAAACCAGTCTCCTTCCTTCATGCCAAGCTGCAGGTAAGATGCTGGTAGGCTGACAGTCTCAAAGACCCAAATTCCTCCCAGGGAATGCCAGGAGGCTGCCTTCACCGCCCAGATACCACCTGTTCCTTCTTTGACAAGGGCACTTAGAACTGAACTACTCATGGATGCAAAAGGACATTTAGAACTGAATCTCTCATGGATGCATCCTTTTTCTATGATGGAGACAGA...	TTTATGGGAGCCTTGGAGAGAGCGGAGCATGGCCCCTGCACTTACAGACGGGGAAGCCTAGAATCCCACAGCCTTTCAGACACCGAGACAGGAAACCAGTCTCCTTCCTTCATGCCAAGCTGCAGGTAAGATGCTGGTAGGCTGACAGTCTCAAAGACCCAAATTCCTCCCAGGGAATGCCAGGAGGCTGCCTTCACCGCCCAGATACCACCTGTTCCTTCTTTGACAAGGGCACTTAGAACTGAACTACTCATGGATGCAAAAGGACATTTAGAACTGAATCTCTCATGGATGCATCCTTTTTCTATGATGGAGACAGA...
Task1_train_44510	Chromosome 16 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	CAGTCTCCTTCCTTCATGCCAAGCTGCAGGTAAGATGCTGGTAGGCTGACAGTCTCAAAGACCCAAATTCCTCCCAGGGAATGCCAGGAGGCTGCCTTCACCGCCCAGATACCACCTGTTCCTTCTTTGACAAGGGCACTTAGAACTGAACTACTCATGGATGCAAAAGGACATTTAGAACTGAATCTCTCATGGATGCATCCTTTTTCTATGATGGAGACAGAAAAGGATGGTCTTATCTGAAACCCTGCAAGCCCCGGTCTGCCCTGCCTTGCCTACTCTTGCTCCCCAAGGTGAGGTGGCATGGAGGAGCAGGGTTC...	CAGTCTCCTTCCTTCATGCCAAGCTGCAGGTAAGATGCTGGTAGGCTGACAGTCTCAAAGACCCAAATTCCTCCCAGGGAATGCCAGGAGGCTGCCTTCACCGCCCAGATACCACCTGTTCCTTCTTTGACAAGGGCACTTAGAACTGAACTACTCATGGATGCAAAAGGACATTTAGAACTGAATCTCTCATGGATGCATCCTTTTTCTATGATGGAGACAGAAAAGGATGGTCTTATCTGAAACCCTGCAAGCCCCGGTCTGCCCTGCCTTGCCTACTCTTGCTCCCCAAGGTGAGGTGGCATGGAGGAGCAGGGTTC...
Task1_train_44511	Here’s a variant located on Chromosome 16. What is the predicted biological effect — harmless or disease-causing?	Benign	TCTCGATAGGATGGAGTTGATGGTCAATCAAGCAGTAGAATGGGATGAAAATCTGCAATAGTTAAAAAATCTTTGCGTGTAAGGAAAAGAACGGCAATGACAAGGGAGAAAAGAGAGCCTTCTCTTTTTCTTAAATAAGACAGGAAACTGCATTATTTCCCTTGCTGGAGTGGCAGCAGCCTCATTGGTTTTCATAAAACATCATTTCTGCAGTGCGGCCTGTTGATAAGGTTGTTCCAAGATGGGAGGACAGACACGAGGCCGACTACTCATGACAGAACTAGGCCTTCTCTCAAAGCCTCTAACGTGTGCTGTTTCTC...	TCTCGATAGGATGGAGTTGATGGTCAATCAAGCAGTAGAATGGGATGAAAATCTGCAATAGTTAAAAAATCTTTGCGTGTAAGGAAAAGAACGGCAATGACAAGGGAGAAAAGAGAGCCTTCTCTTTTTCTTAAATAAGACAGGAAACTGCATTATTTCCCTTGCTGGAGTGGCAGCAGCCTCATTGGTTTTCATAAAACATCATTTCTGCAGTGCGGCCTGTTGATAAGGTTGTTCCAAGATGGGAGGACAGACACGAGGCCGACTACTCATGACAGAACTAGGCCTTCTCTCAAAGCCTCTAACGTGTGCTGTTTCTC...
Task1_train_44512	Chromosome 16 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	TACTGGTCTTTCATCTTAGGGTAGGGAGGGACATGGACATGGATGGACACACACACACACACACACACACACACACCCACAAGCTCTATGCCCTCGTGGCATTCTCTCCCAGCATGAGAGCATGTGTCATGCTGGATGCTGTAGCTTACCATATAAGCCCATGTTCTTGGCATATGATTGGCAGAGGCAAACATTAATGCCCTGTTCGATGAAGTGGCGCACAGCCCAGGCATCCTTATCACCATCACCACTGGCAAAGCCTTGGTAGGCCATGTCAAAGAACGCAAAGAGATTCCTTTTCTGAGAAGGAACGAAAGATC...	TACTGGTCTTTCATCTTAGGGTAGGGAGGGACATGGACATGGATGGACACACACACACACACACACACACACACACCCACAAGCTCTATGCCCTCGTGGCATTCTCTCCCAGCATGAGAGCATGTGTCATGCTGGATGCTGTAGCTTACCATATAAGCCCATGTTCTTGGCATATGATTGGCAGAGGCAAACATTAATGCCCTGTTCGATGAAGTGGCGCACAGCCCAGGCATCCTTATCACCATCACCACTGGCAAAGCCTTGGTAGGCCATGTCAAAGAACGCAAAGAGATTCCTTTTCTGAGAAGGAACGAAAGATC...
Task1_train_44513	This genomic variant is located on Chromosome 16. Can you determine its pathogenicity and name any linked disease?	Benign	TGCCTGCAGTCCCAGCTACTTGGGAGGCTGAAGCAGGAGGACCACTTGAGCCTGGAAGGTCAGGCTGCAGTGAGCCATGATTGTGCCACTGCACTCCAGCCTGGGCAACACAGTGAGACCCTGTATTTAAAGAAAAAAAAAAAGGGAATTTTTTTTGGTACATATTTTGCAGCACTGTGGTTCCCCTGTGTAAGATTAGTCGAGAGAAGGAACAATAAAATCTGTAACTGGTTATGATCAATTAGTTGTAAACACCATTACACTTGGACCAGCCTATGTTCAGATTTTGATCTAAGATACAACATTAAAATGTCATACTG...	TGCCTGCAGTCCCAGCTACTTGGGAGGCTGAAGCAGGAGGACCACTTGAGCCTGGAAGGTCAGGCTGCAGTGAGCCATGATTGTGCCACTGCACTCCAGCCTGGGCAACACAGTGAGACCCTGTATTTAAAGAAAAAAAAAAAGGGAATTTTTTTTGGTACATATTTTGCAGCACTGTGGTTCCCCTGTGTAAGATTAGTCGAGAGAAGGAACAATAAAATCTGTAACTGGTTATGATCAATTAGTTGTAAACACCATTACACTTGGACCAGCCTATGTTCAGATTTTGATCTAAGATACAACATTAAAATGTCATACTG...
Task1_train_44514	Consider this mutation on Chromosome 16. Is this a benign change or a disease-causing variant?	Benign	TTTATAATTGTCTACAAGCTCCTAGAAAAAAAGGCTTATTCATTTTTGTATCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTT...	TTTATAATTGTCTACAAGCTCCTAGAAAAAAAGGCTTATTCATTTTTGTATCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTT...
Task1_train_44515	Given this variant on Chromosome 16, classify it as benign or pathogenic. Include the disorder it may cause if applicable.	Benign	TTATTCATTTTTGTATCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTT...	TTATTCATTTTTGTATCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTT...
Task1_train_44516	A mutation found on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	TCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTTTCAAAATGAATGCTA...	TCCATAGCACCTGGCATGGCTTCTGGCAGGGAAGTGGCATGCAATAAATTTTTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTTTCAAAATGAATGCTA...
Task1_train_44517	A mutation on Chromosome 16 is under review. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.	Benign	TTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTTTCAAAATGAATGCTAGATCTTTCTGGCTCTAACCTGTTAAAAGGGTCCTGCGGTTTCTTTCTGCAT...	TTTTAAATGTAATAATTTTAGCTCATTGTTATTAGTACTATGTGTATTAGTGGGGCATTCCCATTTCAGTTTTGGACACATTACCATGAGGGAGAAAATCAGAAATCAAAGAAGAAATTTCTACTAAGCTTCATATAATACATGAAAATAATCCTAGCATATCTAATATATGTAAGAAATAATGGTGCAGTTACTAATATAATACATTATACAATGTTTCATAGCATATATACTATGTGAGACGTGTCACTTTTTCAAAATGAATGCTAGATCTTTCTGGCTCTAACCTGTTAAAAGGGTCCTGCGGTTTCTTTCTGCAT...
Task1_train_44518	This variant is found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.	Benign	ATCTTATTTTGGAAGGGATTCTCATACTCTGGATAATCAGACTTCTTTTCTCTAAGACTTACAAATTACAAGAACGATCTGATCTTACAGTCGAGGAAAAAGAAGAACTGATTGAAGAGTGGTAACCAGAACCTCTTGTTCCTCCTGTCCCAAAAGACCATCCTGCTCTCAATTACAACATCGTTTCAGGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTAAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACAAGCC...	ATCTTATTTTGGAAGGGATTCTCATACTCTGGATAATCAGACTTCTTTTCTCTAAGACTTACAAATTACAAGAACGATCTGATCTTACAGTCGAGGAAAAAGAAGAACTGATTGAAGAGTGGTAACCAGAACCTCTTGTTCCTCCTGTCCCAAAAGACCATCCTGCTCTCAATTACAACATCGTTTCAGGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTAAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACAAGCC...
Task1_train_44519	A mutation is present on Chromosome 16. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	TCAATTACAACATCGTTTCAGGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTAAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACAAGCCACCATGCCCACCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGAATGATCTCGATCTCCTTTTTTTTAATTAAAAAGTAAACTTTAATGTCGAAAATGCAAACTTGGGGAGGGCAGAAAGATCACACACAAGGCTGTCACTTCACACGTGGA...	TCAATTACAACATCGTTTCAGGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTAAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACAAGCCACCATGCCCACCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGAATGATCTCGATCTCCTTTTTTTTAATTAAAAAGTAAACTTTAATGTCGAAAATGCAAACTTGGGGAGGGCAGAAAGATCACACACAAGGCTGTCACTTCACACGTGGA...
Task1_train_44520	A mutation has occurred on Chromosome 16. What is the medical relevance of this mutation?	Benign	GAAAGTCAGCAAGAGATGCAAGCTTTCATTCTGTGTTCCTAGGCAAAGAGAATACTTAGGCGATATTTGGGCAACTAGTAGAGCAGACATTATCTCCTGCTCACAGAAACCACTGTACGAAGATTATCCTGTTGATTACCAATATTTGAGGATACAGATTTTATACTCCTTAAAAAATACTGTAATTATTCTGTTAGACATATTTGTGTGTCTATAATCTTTGGGCACTTCAAAGTACACTAGAAATGAGTCTGGTGTTCAAGAGATACATAAAACATAATAATCTCTCCTTGGTTTGGAAGGTGTAAGATAGTTGGAAT...	GAAAGTCAGCAAGAGATGCAAGCTTTCATTCTGTGTTCCTAGGCAAAGAGAATACTTAGGCGATATTTGGGCAACTAGTAGAGCAGACATTATCTCCTGCTCACAGAAACCACTGTACGAAGATTATCCTGTTGATTACCAATATTTGAGGATACAGATTTTATACTCCTTAAAAAATACTGTAATTATTCTGTTAGACATATTTGTGTGTCTATAATCTTTGGGCACTTCAAAGTACACTAGAAATGAGTCTGGTGTTCAAGAGATACATAAAACATAATAATCTCTCCTTGGTTTGGAAGGTGTAAGATAGTTGGAAT...
Task1_train_44521	A variant on Chromosome 16 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	TTTAATACTCTGTGCAACACACAATATAGGGAAGCCAGGGTTGAAAATCTTTCCTCTATCATTTCCAAGCAAAGTGGTCTTGGGCAAGTTACTTCAGCTCATTATGTTTTAATTTCCCCTTACAGAGATTTCATCAGTTCTAATACTTTGTCTATATTTATCAATAGTATTTTGCTTTGCAACTTTCTTTTGGATTCATAATCTATTTAATCTCACCATGCCCTCTATATTAAAGGATGAGTGGGAAGTGGGAGTCCCTTGTAGATAATTACCAATTAATGTGAAGGTTTAAAAAAAAATGTCCTATGTGGATTTTGTCC...	TTTAATACTCTGTGCAACACACAATATAGGGAAGCCAGGGTTGAAAATCTTTCCTCTATCATTTCCAAGCAAAGTGGTCTTGGGCAAGTTACTTCAGCTCATTATGTTTTAATTTCCCCTTACAGAGATTTCATCAGTTCTAATACTTTGTCTATATTTATCAATAGTATTTTGCTTTGCAACTTTCTTTTGGATTCATAATCTATTTAATCTCACCATGCCCTCTATATTAAAGGATGAGTGGGAAGTGGGAGTCCCTTGTAGATAATTACCAATTAATGTGAAGGTTTAAAAAAAAATGTCCTATGTGGATTTTGTCC...
Task1_train_44522	This genomic variant is located on Chromosome 16. Can you determine its pathogenicity and name any linked disease?	Benign	ATCGGAATCTCATGCATGTCACAGTTTGAAAACCACTGTCATGAAACAGGCTGTGCAGATGTCTCTGTGACGAGAATCACCCAAGTCACCTATTAAGCATAAAGCTCTACTCCACCCTGCAGGTTCTGGTCCAGTGAGCCAGAGATGTGCATTTAACAAGGGTCCCATGATTCTTAGTTATCATGGCTGTTTGGGAAATGTTCCTTCAGAGGGTGTTTATGCACCAGTTAATAGGTAGAATTCAAAATGTGAAGCAGCTTCCAATTTTGAGATTGTGAGTTTCTCTAGAAATTGTGTAATTTTTGCCAGAGGGAGGGGCA...	ATCGGAATCTCATGCATGTCACAGTTTGAAAACCACTGTCATGAAACAGGCTGTGCAGATGTCTCTGTGACGAGAATCACCCAAGTCACCTATTAAGCATAAAGCTCTACTCCACCCTGCAGGTTCTGGTCCAGTGAGCCAGAGATGTGCATTTAACAAGGGTCCCATGATTCTTAGTTATCATGGCTGTTTGGGAAATGTTCCTTCAGAGGGTGTTTATGCACCAGTTAATAGGTAGAATTCAAAATGTGAAGCAGCTTCCAATTTTGAGATTGTGAGTTTCTCTAGAAATTGTGTAATTTTTGCCAGAGGGAGGGGCA...
Task1_train_44523	Chromosome 16 is altered by this variant. Does this mutation result in a disease or is it benign?	Benign	GAAACAGGCTGTGCAGATGTCTCTGTGACGAGAATCACCCAAGTCACCTATTAAGCATAAAGCTCTACTCCACCCTGCAGGTTCTGGTCCAGTGAGCCAGAGATGTGCATTTAACAAGGGTCCCATGATTCTTAGTTATCATGGCTGTTTGGGAAATGTTCCTTCAGAGGGTGTTTATGCACCAGTTAATAGGTAGAATTCAAAATGTGAAGCAGCTTCCAATTTTGAGATTGTGAGTTTCTCTAGAAATTGTGTAATTTTTGCCAGAGGGAGGGGCAAGAGTTGGAGTTTTGCATCCTCTATCTATATTAGAAAATCAC...	GAAACAGGCTGTGCAGATGTCTCTGTGACGAGAATCACCCAAGTCACCTATTAAGCATAAAGCTCTACTCCACCCTGCAGGTTCTGGTCCAGTGAGCCAGAGATGTGCATTTAACAAGGGTCCCATGATTCTTAGTTATCATGGCTGTTTGGGAAATGTTCCTTCAGAGGGTGTTTATGCACCAGTTAATAGGTAGAATTCAAAATGTGAAGCAGCTTCCAATTTTGAGATTGTGAGTTTCTCTAGAAATTGTGTAATTTTTGCCAGAGGGAGGGGCAAGAGTTGGAGTTTTGCATCCTCTATCTATATTAGAAAATCAC...
Task1_train_44524	Given this context: Chromosome 16 — does this variant present pathogenic behavior, and if so, what disease does it relate to?	Benign	TGTCTGCAGGCAAGCAGCCCTCACCCACAGGGCCAGGTGGCTCCTGGGCAGGAGGGCCCCTCCATGGCTCTGTCTGCCAGAGGAAGTGGCCCTTGCTCTGGGTGGCTGCTGTTGTGGGGATCCCAGCCCTGTCCCAAAAGTCAGCCCTGAGCTGGTGCATGCACTAGAGTTCCTGGAGCTGATCTCTGTCAACCTGCTTCTGTTTCCCTGGAGGAAGGAAATCAGGTCCCTAAAGGTAGGCACTGCCACATGTCTGAGCAAGGGGGATTCAGCCAGGGGTTGGGGCTCTGCCTCTGGGAGAAACAGCATGCCCATCATAT...	TGTCTGCAGGCAAGCAGCCCTCACCCACAGGGCCAGGTGGCTCCTGGGCAGGAGGGCCCCTCCATGGCTCTGTCTGCCAGAGGAAGTGGCCCTTGCTCTGGGTGGCTGCTGTTGTGGGGATCCCAGCCCTGTCCCAAAAGTCAGCCCTGAGCTGGTGCATGCACTAGAGTTCCTGGAGCTGATCTCTGTCAACCTGCTTCTGTTTCCCTGGAGGAAGGAAATCAGGTCCCTAAAGGTAGGCACTGCCACATGTCTGAGCAAGGGGGATTCAGCCAGGGGTTGGGGCTCTGCCTCTGGGAGAAACAGCATGCCCATCATAT...
Task1_train_44525	This alteration on Chromosome 16 may affect genome function. Does it lead to a disease or is it benign?	Benign	TGCTCTGGGTGGCTGCTGTTGTGGGGATCCCAGCCCTGTCCCAAAAGTCAGCCCTGAGCTGGTGCATGCACTAGAGTTCCTGGAGCTGATCTCTGTCAACCTGCTTCTGTTTCCCTGGAGGAAGGAAATCAGGTCCCTAAAGGTAGGCACTGCCACATGTCTGAGCAAGGGGGATTCAGCCAGGGGTTGGGGCTCTGCCTCTGGGAGAAACAGCATGCCCATCATATCCATTGACTTCAGTCCCATTTCAGTTTAAGAAATTGAGGGCTAAAGAGACAGATGCAACTTATCCATGGTCAACAGCTAGCAAGTGGTACAAC...	TGCTCTGGGTGGCTGCTGTTGTGGGGATCCCAGCCCTGTCCCAAAAGTCAGCCCTGAGCTGGTGCATGCACTAGAGTTCCTGGAGCTGATCTCTGTCAACCTGCTTCTGTTTCCCTGGAGGAAGGAAATCAGGTCCCTAAAGGTAGGCACTGCCACATGTCTGAGCAAGGGGGATTCAGCCAGGGGTTGGGGCTCTGCCTCTGGGAGAAACAGCATGCCCATCATATCCATTGACTTCAGTCCCATTTCAGTTTAAGAAATTGAGGGCTAAAGAGACAGATGCAACTTATCCATGGTCAACAGCTAGCAAGTGGTACAAC...
Task1_train_44526	A variant on Chromosome 16 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	AGCAAGACGCCGTCTCTTAAATGTATAAACAAACAAAAATACATTAATTACCATCCAGCTCAACTTTGCATTTCCCTCCCCTTCTATGGCACCCGCTGGCATATCCTTCTCCTAATTTCAACAAACTTCCACAAATCTCAAGCATTTCAATCCTCTCTATGTGGTTTCACTACTTCCCAAGAGCTCTCCACCACCCTGAGTACGCTGGGGGCCTGCCCGCACTGTCTACCCTCTGCAGATCCCAGCCACGGTACTCCTGCCACCACTTGCCAAGCCACCCCCTTCCCAGCCACTGGAGCTAGGGACTTTCAGTTCTTTTA...	AGCAAGACGCCGTCTCTTAAATGTATAAACAAACAAAAATACATTAATTACCATCCAGCTCAACTTTGCATTTCCCTCCCCTTCTATGGCACCCGCTGGCATATCCTTCTCCTAATTTCAACAAACTTCCACAAATCTCAAGCATTTCAATCCTCTCTATGTGGTTTCACTACTTCCCAAGAGCTCTCCACCACCCTGAGTACGCTGGGGGCCTGCCCGCACTGTCTACCCTCTGCAGATCCCAGCCACGGTACTCCTGCCACCACTTGCCAAGCCACCCCCTTCCCAGCCACTGGAGCTAGGGACTTTCAGTTCTTTTA...
Task1_train_44527	Here is a mutation located on Chromosome 16. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?	Benign	AGGAATTAAGTGACCATAAAGAGAAACATCCAAGGTTGTCAAGAGTCCCGGAGTGCACAGGGGAATATCTGTGCCATCAGCCCCTGGTCCCCATCGGCTGACTCCGCTATCACTCCTTCTACTGCCAGGGGTTCCCACCCCCAGGTATCCATTTCTTACCTGGATGGCAGCATCCCACCCCACCACGCACTGGTCTTCCTGCCTCCAGCCTGGTTCACCTTCCATTCACCTCATGAACACTGCAAGCAGGTTTTCTGAATCTCACACCTGACCTCCTGATAGAGTCCCAGATCCTGCACCTCTCCAGCCTCAACTCTGCC...	AGGAATTAAGTGACCATAAAGAGAAACATCCAAGGTTGTCAAGAGTCCCGGAGTGCACAGGGGAATATCTGTGCCATCAGCCCCTGGTCCCCATCGGCTGACTCCGCTATCACTCCTTCTACTGCCAGGGGTTCCCACCCCCAGGTATCCATTTCTTACCTGGATGGCAGCATCCCACCCCACCACGCACTGGTCTTCCTGCCTCCAGCCTGGTTCACCTTCCATTCACCTCATGAACACTGCAAGCAGGTTTTCTGAATCTCACACCTGACCTCCTGATAGAGTCCCAGATCCTGCACCTCTCCAGCCTCAACTCTGCC...
Task1_train_44528	Consider this mutation on Chromosome 16. Is this a benign change or a disease-causing variant?	Benign	AGTCCCGGCTACTCAGGAGGCTGAGGCAGAAGGACTGCTTGAGCCTGGGAGGCAGAGGTTGTGGTGAGCTGTGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGACACCCTGCCTCAAAAAACAAAAACAAAACAAAAAAGGCAAAAAACAAAAAACCCAAAACCATGAGTTCACACTGATACCTCCAATTCCAATCCAATGCCATATACATTTAACTTATTTGACCAATGCCTGTATGCAGCCCCTCTTCCATCACCTCCATCCCTGCACAGATGCCCTCCTTACCACATGACCCTGCCCTGGGCCACCCCACT...	AGTCCCGGCTACTCAGGAGGCTGAGGCAGAAGGACTGCTTGAGCCTGGGAGGCAGAGGTTGTGGTGAGCTGTGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGACACCCTGCCTCAAAAAACAAAAACAAAACAAAAAAGGCAAAAAACAAAAAACCCAAAACCATGAGTTCACACTGATACCTCCAATTCCAATCCAATGCCATATACATTTAACTTATTTGACCAATGCCTGTATGCAGCCCCTCTTCCATCACCTCCATCCCTGCACAGATGCCCTCCTTACCACATGACCCTGCCCTGGGCCACCCCACT...
Task1_train_44529	Chromosome 16 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	AAAGATTCCTACAGCAGAGTACTGAGCAGCCTGGAAGAAGGAAGCAGCTCTCTACACCCCAAGCTCCCCGCTCTGTGACTTCTTTAGTGCTCCTTGTAATATTAGGTATTAGGGAAGAGCAAGGGAAAATGGGCAAGAGGGCTTAATTCTAAGGACTCTTTTATTTTTCAAGCCCTCTCAAAACACCAATCCATCCTGAAATAGAGACTTGGGGAAATCTGTAAATGCTTAGGACAGTGGTTCCTTCTCAGAAGAATGGGCTCACATTTGAGTATAAAGTATAATTAAATGAACGGTGGTGAGTATCCTAAAAAAAGGTT...	AAAGATTCCTACAGCAGAGTACTGAGCAGCCTGGAAGAAGGAAGCAGCTCTCTACACCCCAAGCTCCCCGCTCTGTGACTTCTTTAGTGCTCCTTGTAATATTAGGTATTAGGGAAGAGCAAGGGAAAATGGGCAAGAGGGCTTAATTCTAAGGACTCTTTTATTTTTCAAGCCCTCTCAAAACACCAATCCATCCTGAAATAGAGACTTGGGGAAATCTGTAAATGCTTAGGACAGTGGTTCCTTCTCAGAAGAATGGGCTCACATTTGAGTATAAAGTATAATTAAATGAACGGTGGTGAGTATCCTAAAAAAAGGTT...
Task1_train_44530	A mutation is present on Chromosome 16. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	CACAATGAGAGATACCAGACTTCAAGTCCCTGAAAAGGTGAGCTTTAAATCCAAATTTGGGCATGTTCTGAAAGTCTAAATATAATCTTTAAAGAATAATATACAGGCCATCTTTAAAACAGCATTTTTGTTGACACTGTAAAGAGAGATACCCCTAGACTAAGCCTAAAAGACATCACAAACAACAGGCATTATTGTTAATTATATGCTAACACCTACGGATCAATACAAGAGCTTAGGAAGTGCCCATATTCCATGAATAAAGGAATAACGACTACTCCTTTGTATTAATAACAATAAAGACAGTAATGATGGGTAAC...	CACAATGAGAGATACCAGACTTCAAGTCCCTGAAAAGGTGAGCTTTAAATCCAAATTTGGGCATGTTCTGAAAGTCTAAATATAATCTTTAAAGAATAATATACAGGCCATCTTTAAAACAGCATTTTTGTTGACACTGTAAAGAGAGATACCCCTAGACTAAGCCTAAAAGACATCACAAACAACAGGCATTATTGTTAATTATATGCTAACACCTACGGATCAATACAAGAGCTTAGGAAGTGCCCATATTCCATGAATAAAGGAATAACGACTACTCCTTTGTATTAATAACAATAAAGACAGTAATGATGGGTAAC...
Task1_train_44531	This variant is found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.	Benign	GAGCTGCCACATCTGGGCATTGTGGCTGACCACCACGGGGATTATGTGTTCACGTGGCTCCACCCAATGCAGGGCCAAGGTGAGGTAGGCATGGGAACCTTTTGGGACAGCAGGCAAAGACCAGGGTCACCAGCCTGGACAGGCCCTCTGGGGGCTGCTCCCCCTAGGCCTAGCCCCACCCCCATGGTAGAAGGGTATCTCACTTCCAAGTGACACCCCCTCCCTGCCTTGGCCACAGCCTCCCTCCCTTTCCCCACCACACACCATTGAGAGTCTGGAGGCGCCAATCCCGTTGCACCGTGGGGTTGGGACCAAGGGTG...	GAGCTGCCACATCTGGGCATTGTGGCTGACCACCACGGGGATTATGTGTTCACGTGGCTCCACCCAATGCAGGGCCAAGGTGAGGTAGGCATGGGAACCTTTTGGGACAGCAGGCAAAGACCAGGGTCACCAGCCTGGACAGGCCCTCTGGGGGCTGCTCCCCCTAGGCCTAGCCCCACCCCCATGGTAGAAGGGTATCTCACTTCCAAGTGACACCCCCTCCCTGCCTTGGCCACAGCCTCCCTCCCTTTCCCCACCACACACCATTGAGAGTCTGGAGGCGCCAATCCCGTTGCACCGTGGGGTTGGGACCAAGGGTG...
Task1_train_44532	An alteration has been detected on Chromosome 16. Is it pathogenic, and if so, what disease is involved?	Benign	GGGGGCGGGGCCTGGCGCTCGGTGGAAGGGGCGGGCGCTCCATACCATCTGGATGGGGCGAGCTAACTCCAAGGAAGGGGGTGTGGTCGCAGGACTGGGTCTTAGAGGGGCAAGGCTGGGCTGGGTGGGGGAAGCCCAGGAGGGCAGCCCAACGCGCCCCGACTGTCGAGGCCCGGGACCCTGACAGTGAACCCCACACGCCCAGCACGGACGACAGCCACGCGCGCGGGAACTGGGGGCTGCTGGACCAGATGGCGGCTCTGCGCTGGGTGCAGGAGAACATCGCAGCCTTCGGGGGAGACCCAGGAAATGTGACCCTG...	GGGGGCGGGGCCTGGCGCTCGGTGGAAGGGGCGGGCGCTCCATACCATCTGGATGGGGCGAGCTAACTCCAAGGAAGGGGGTGTGGTCGCAGGACTGGGTCTTAGAGGGGCAAGGCTGGGCTGGGTGGGGGAAGCCCAGGAGGGCAGCCCAACGCGCCCCGACTGTCGAGGCCCGGGACCCTGACAGTGAACCCCACACGCCCAGCACGGACGACAGCCACGCGCGCGGGAACTGGGGGCTGCTGGACCAGATGGCGGCTCTGCGCTGGGTGCAGGAGAACATCGCAGCCTTCGGGGGAGACCCAGGAAATGTGACCCTG...
Task1_train_44533	Here is a genetic alteration on Chromosome 16. Based on the data, is it a benign variant or a cause of disease?	Benign	AGTGAAAACTGGCCATGAATGATGGAGGGGAAGAAGGGAGAAGTATGGCCTGCTGGAGATTTGAGGACCACAAATTCTCAGATCATAGTTTAGATGGGTTATGATGTTCATTCCCAAGCCTCTAGGCAACTGCAAATCCTGAAGCCCTCCCTTGCTCCTGGGTCAGGGTAGATGCCCCAACTCAGGATGGACCCCCACTCAGTACCACTTCAGCTCTGGCCCAGGTGGTAGTGATGAGCAGGATGGGAGCAGGGGGACAAGAGAGAGTCATGGGCCCTTCCTGGGCTGTGTGCTGTGTCTGATAACTCATCATTAGATGG...	AGTGAAAACTGGCCATGAATGATGGAGGGGAAGAAGGGAGAAGTATGGCCTGCTGGAGATTTGAGGACCACAAATTCTCAGATCATAGTTTAGATGGGTTATGATGTTCATTCCCAAGCCTCTAGGCAACTGCAAATCCTGAAGCCCTCCCTTGCTCCTGGGTCAGGGTAGATGCCCCAACTCAGGATGGACCCCCACTCAGTACCACTTCAGCTCTGGCCCAGGTGGTAGTGATGAGCAGGATGGGAGCAGGGGGACAAGAGAGAGTCATGGGCCCTTCCTGGGCTGTGTGCTGTGTCTGATAACTCATCATTAGATGG...
Task1_train_44534	This variant is found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.	Benign	CACTCCCTAGATGTTCTCATCCACTCTTGTGGTTTTACATACATTAGCTCAGACTTCTTCCATAAACTTTAGACCAGTGTTGCCAATTTCAGTGCAATTTGAGATACTGTCTATTTGCCCAGGCTGGTCTTGAATTCCTGGCCTCAAGCAATCTTCCCACCTCAGCCTTCCAACTAGCTGGAACCACAGGCACATGCCATCATGTCCATCTTCACTGCAGTGTCATCACTTGAATGTTTAATAGGCATATCAAACAGAATATGTCCTCTGTCTGGGATGTTCCTCCCCCTGTATAATGGCATGGGTCACTCTCTCACTTT...	CACTCCCTAGATGTTCTCATCCACTCTTGTGGTTTTACATACATTAGCTCAGACTTCTTCCATAAACTTTAGACCAGTGTTGCCAATTTCAGTGCAATTTGAGATACTGTCTATTTGCCCAGGCTGGTCTTGAATTCCTGGCCTCAAGCAATCTTCCCACCTCAGCCTTCCAACTAGCTGGAACCACAGGCACATGCCATCATGTCCATCTTCACTGCAGTGTCATCACTTGAATGTTTAATAGGCATATCAAACAGAATATGTCCTCTGTCTGGGATGTTCCTCCCCCTGTATAATGGCATGGGTCACTCTCTCACTTT...
Task1_train_44535	A mutation found on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	GCTTCACTCCCTTTAACTAACTGTACAGTTTTTTGGACTCCTCACCCCTTTACAGGTTTCTGCTTGGCCCAGTCCCCTCCATCTCCCCTTCTTTCATTCGACATACCTCCTCGAAATTACCAGAATACGCCTGTTTTTTTCACGTCTCGGGTCCTTCCGCCAAGAATGCCTTTGCAATATATTCCTGGAGCAAACTCTTAACCATTCTTCAAGGCTCAGTTTAGGCCTCACTTCCTCCAGGAAGCCTTCCCCGCGTCTAGTGTCCCACTGCTTCGGCGACTTCTTTACTCAGAGCTGTCACTGTTGGAGTCTAGGTCCGT...	GCTTCACTCCCTTTAACTAACTGTACAGTTTTTTGGACTCCTCACCCCTTTACAGGTTTCTGCTTGGCCCAGTCCCCTCCATCTCCCCTTCTTTCATTCGACATACCTCCTCGAAATTACCAGAATACGCCTGTTTTTTTCACGTCTCGGGTCCTTCCGCCAAGAATGCCTTTGCAATATATTCCTGGAGCAAACTCTTAACCATTCTTCAAGGCTCAGTTTAGGCCTCACTTCCTCCAGGAAGCCTTCCCCGCGTCTAGTGTCCCACTGCTTCGGCGACTTCTTTACTCAGAGCTGTCACTGTTGGAGTCTAGGTCCGT...
Task1_train_44536	A genetic alteration is present on Chromosome 16. Is this variant benign or disease-causing, and if the latter, which condition is involved?	Benign	CCATTGAGTTATAGGTGGAAATGGGGGGCAGGGACCCCTGATGCTGTCGGCCTCCCTGTAACTGTCAATTATTCCTTCTTAATGTCTCCAGTCCCTTGTGCATGCCACCATCATAGCAAAAGCCTCCTGACTTCTGGCCTCCTGTCTTGCACTTCCAATCCTCTCAATACCAGCTACCCCAACTGCTTTCTCCGACATAAATCTGATCATACACACACACAAACATCCCATATATTTGATGTCACCCTATCCATGTCCATGGGTTAATGGCCACAGTTTCCATGGCTGAGCCTGAGTTGAGCCAGGTGAGTCTCAGACAT...	CCATTGAGTTATAGGTGGAAATGGGGGGCAGGGACCCCTGATGCTGTCGGCCTCCCTGTAACTGTCAATTATTCCTTCTTAATGTCTCCAGTCCCTTGTGCATGCCACCATCATAGCAAAAGCCTCCTGACTTCTGGCCTCCTGTCTTGCACTTCCAATCCTCTCAATACCAGCTACCCCAACTGCTTTCTCCGACATAAATCTGATCATACACACACACAAACATCCCATATATTTGATGTCACCCTATCCATGTCCATGGGTTAATGGCCACAGTTTCCATGGCTGAGCCTGAGTTGAGCCAGGTGAGTCTCAGACAT...
Task1_train_44537	Consider a variant on Chromosome 16. Determine its clinical classification and disease relevance.	Benign	AGAAGGGAGGGTAGAACTGGGAGGCTCTAGATTAGGAGATGAGATGCAAGGCCAGAGGGACACATTCTCCCCTCTGGCAAAGGCAGGTCTGGGCTGGGGGAATATTTTGGAGGGGAGGAAGGCACTCCTGAGTTCCCCCAGGGACACTAGGCCCGGCCCAAGACACTGTCAAGCTCCCTTCCACCAACCAGGGCCAGGAGATGAGTCAGAGGCTGTGGCCAGGAGCTTCCTCCTAGTCTAGGAGGAAATGAGCAAGGCTTTCTGAGATCTGAAAGCTCTTTAAAAAGGAAGCCCCCAGGGGAACTCTAGGGGCTAGGCTC...	AGAAGGGAGGGTAGAACTGGGAGGCTCTAGATTAGGAGATGAGATGCAAGGCCAGAGGGACACATTCTCCCCTCTGGCAAAGGCAGGTCTGGGCTGGGGGAATATTTTGGAGGGGAGGAAGGCACTCCTGAGTTCCCCCAGGGACACTAGGCCCGGCCCAAGACACTGTCAAGCTCCCTTCCACCAACCAGGGCCAGGAGATGAGTCAGAGGCTGTGGCCAGGAGCTTCCTCCTAGTCTAGGAGGAAATGAGCAAGGCTTTCTGAGATCTGAAAGCTCTTTAAAAAGGAAGCCCCCAGGGGAACTCTAGGGGCTAGGCTC...
Task1_train_44538	This mutation occurs on Chromosome 16. Does this change lead to a known medical condition, or is it benign?	Benign	GGGATGCCCAGAGGGGCACAGTAGAAAGCTCCTCAGTCCTGTCAGAAGGGCCAGGCCCCTCTGGAGTGGAGAGTCTCCTATGCCCCATGTCCTCCCACCTCAGCTTGGCACAGGGTGAGAGTGACACCCCAGGGGTAGGGTTGGTAGGGGACCCAGGTCCAAGCAGGGCGATGCCATCTGGCTTGAGCCCTGGGGCATTGGACAGCGACCCTGTGGGCCTTGGAGACCCTTTATCAGAAATATCAAAGCTGCTGGAGGCAGGTAAGGAAGGCTGGGCTAGGGAAGTCTGGGAAGGGAATGGGGATGCCTGGAGAGATGAG...	GGGATGCCCAGAGGGGCACAGTAGAAAGCTCCTCAGTCCTGTCAGAAGGGCCAGGCCCCTCTGGAGTGGAGAGTCTCCTATGCCCCATGTCCTCCCACCTCAGCTTGGCACAGGGTGAGAGTGACACCCCAGGGGTAGGGTTGGTAGGGGACCCAGGTCCAAGCAGGGCGATGCCATCTGGCTTGAGCCCTGGGGCATTGGACAGCGACCCTGTGGGCCTTGGAGACCCTTTATCAGAAATATCAAAGCTGCTGGAGGCAGGTAAGGAAGGCTGGGCTAGGGAAGTCTGGGAAGGGAATGGGGATGCCTGGAGAGATGAG...
Task1_train_44539	Located on Chromosome 16, this mutation has been observed. What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?	Benign	CAGGAGCAGGTCAGGCAAGGGGAGAAGTTTCTGCAGCCGCTGACTGGCTGGGAGGCGGCTGAACTGGACCCCCCTGGGGCACGCTTTCTGGCCCTGCGAGCCCAGCTGACTGAATTCTCTAGGGCTTTGGCCCAGCGGTGCCAGCGGCTGGCGGATGCTGAGAGGCTGTTTCAGCTCTTCAGGGAGGTGGGTGAGAGTCTCCCCAGCTCCAAGTGATCCATGAGGCCGGAGGGATGGCAGCCCCAGCTTCAGCAGAGCCTGAGCTTTTCTTGGTCATGCTGCCTGTTCTCTTCCCTGGTCTTCAGTTTGACCCTAAAACC...	CAGGAGCAGGTCAGGCAAGGGGAGAAGTTTCTGCAGCCGCTGACTGGCTGGGAGGCGGCTGAACTGGACCCCCCTGGGGCACGCTTTCTGGCCCTGCGAGCCCAGCTGACTGAATTCTCTAGGGCTTTGGCCCAGCGGTGCCAGCGGCTGGCGGATGCTGAGAGGCTGTTTCAGCTCTTCAGGGAGGTGGGTGAGAGTCTCCCCAGCTCCAAGTGATCCATGAGGCCGGAGGGATGGCAGCCCCAGCTTCAGCAGAGCCTGAGCTTTTCTTGGTCATGCTGCCTGTTCTCTTCCCTGGTCTTCAGTTTGACCCTAAAACC...