question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Determine if the mutation at chromosome 1, position 169572348 in gene F5 (coagulation factor V) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
CTACAATTCTTACCTCCTCCCTTATTTGAAATGAAACCTGCATGTGACATTTTGATATTTTGAGGTTTCTCCCCCTTCTTCTTTACATTGCTGAACTTCTGATGCAGTCGTCTAGAAGCCTCATAAGTAGGTGAAGTGGTTGTTCACTATGTCACTGTATGATTTTAAGAACATAGGAGAAACTCCTGTTCCCACTACCTCACCCAGAGTCTTGCCAAATTCACTTTGGAAGAAATCTCAGTGCCACAGTTAATGCTTCATTGTTTTTCCTCAAGCCAAAGATTAAGTGCTAATGCAAGTACTCCTAAGGAAGGTAGTTC...
CTACAATTCTTACCTCCTCCCTTATTTGAAATGAAACCTGCATGTGACATTTTGATATTTTGAGGTTTCTCCCCCTTCTTCTTTACATTGCTGAACTTCTGATGCAGTCGTCTAGAAGCCTCATAAGTAGGTGAAGTGGTTGTTCACTATGTCACTGTATGATTTTAAGAACATAGGAGAAACTCCTGTTCCCACTACCTCACCCAGAGTCTTGCCAAATTCACTTTGGAAGAAATCTCAGTGCCACAGTTAATGCTTCATTGTTTTTCCTCAAGCCAAAGATTAAGTGCTAATGCAAGTACTCCTAAGGAAGGTAGTTC...
benign
17,623
Is the variant located on chromosome 1 at position 170539403, gene GORAB (golgin, RAB6 interacting), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Geroderma_osteodysplastica']
CTCTTCTCCTTGTGTTGTGGTGGCCAGCAACACTGAATACTGACTGTACAGTCAGCCTAGAGCCTTGAGAGACTAATCAGCAGAACCTCTCTGTTAGCCTTTAGTTGGCACTTGGCATTAATGAAAAATAAACCTTTGTGGTTTAAAACCACTAAGATTTGCCCCTACAGCGTAATCTAGATTTTCCTGATTGAAACAGTTCCCTACATTTAAAAATCAAGATATTTTACATAAAAGTCTAAATTGTAATCATAAAAATCAAAATATCTGGCTATGGTGACCTAAATTTTTTAATGATAGCAATTGACTAAAGGTGACTC...
CTCTTCTCCTTGTGTTGTGGTGGCCAGCAACACTGAATACTGACTGTACAGTCAGCCTAGAGCCTTGAGAGACTAATCAGCAGAACCTCTCTGTTAGCCTTTAGTTGGCACTTGGCATTAATGAAAAATAAACCTTTGTGGTTTAAAACCACTAAGATTTGCCCCTACAGCGTAATCTAGATTTTCCTGATTGAAACAGTTCCCTACATTTAAAAATCAAGATATTTTACATAAAAGTCTAAATTGTAATCATAAAAATCAAAATATCTGGCTATGGTGACCTAAATTTTTTAATGATAGCAATTGACTAAAGGTGACTC...
pathogenic
17,648
Mutation at chromosome 1, position 170539554, within GORAB (golgin, RAB6 interacting): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Geroderma_osteodysplastica']
CTAAGATTTGCCCCTACAGCGTAATCTAGATTTTCCTGATTGAAACAGTTCCCTACATTTAAAAATCAAGATATTTTACATAAAAGTCTAAATTGTAATCATAAAAATCAAAATATCTGGCTATGGTGACCTAAATTTTTTAATGATAGCAATTGACTAAAGGTGACTCGGAATTTGCCCCCTTTACACTAGACTTACGCTTCTCAGTTCACCACAGTCTCCTTGATATTTGCAGCCCCTAATACAGAGTGTGGGAAGCAATATGTTCTGTGTTTAAGTGGCCTGATTTGCTTATTGTTTATTGTTTAAAATTAGCATTT...
CTAAGATTTGCCCCTACAGCGTAATCTAGATTTTCCTGATTGAAACAGTTCCCTACATTTAAAAATCAAGATATTTTACATAAAAGTCTAAATTGTAATCATAAAAATCAAAATATCTGGCTATGGTGACCTAAATTTTTTAATGATAGCAATTGACTAAAGGTGACTCGGAATTTGCCCCCTTTACACTAGACTTACGCTTCTCAGTTCACCACAGTCTCCTTGATATTTGCAGCCCCTAATACAGAGTGTGGGAAGCAATATGTTCTGTGTTTAAGTGGCCTGATTTGCTTATTGTTTATTGTTTAAAATTAGCATTT...
pathogenic
17,651
Regarding the variant found on chromosome 1 at position 171636250 in gene MYOC (myocilin): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Glaucoma_of_childhood']
TTGGCTGACAACACATTGATGTGATGGAATCCAAGCTGAACTGGCAAATGAAGTGTTCTACCATTAGGTACAATGGCAACTGAAGAGGGAAATTAAGTTTGTTATTAAAAAATAATGCAGCTAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTCTGGAGGCCGAGATGGGAGGATTACTTGAGGCCAGGAGTTTGAGACAAGTTGGTCAACATAGTACAATCCTGTCTCTACAAAAAAATTTAGAAAATAATAATATTGCTATAAGGGCTGAGGATAATGGAGTTATTAATGGGTGTATTAATAACCGTAAAGTCAC...
TTGGCTGACAACACATTGATGTGATGGAATCCAAGCTGAACTGGCAAATGAAGTGTTCTACCATTAGGTACAATGGCAACTGAAGAGGGAAATTAAGTTTGTTATTAAAAAATAATGCAGCTAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTCTGGAGGCCGAGATGGGAGGATTACTTGAGGCCAGGAGTTTGAGACAAGTTGGTCAACATAGTACAATCCTGTCTCTACAAAAAAATTTAGAAAATAATAATATTGCTATAAGGGCTGAGGATAATGGAGTTATTAATGGGTGTATTAATAACCGTAAAGTCAC...
pathogenic
17,733
Mutation at chromosome 1, position 171636337, within MYOC (myocilin): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Glaucoma_of_childhood']
GGAAATTAAGTTTGTTATTAAAAAATAATGCAGCTAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTCTGGAGGCCGAGATGGGAGGATTACTTGAGGCCAGGAGTTTGAGACAAGTTGGTCAACATAGTACAATCCTGTCTCTACAAAAAAATTTAGAAAATAATAATATTGCTATAAGGGCTGAGGATAATGGAGTTATTAATGGGTGTATTAATAACCGTAAAGTCACCGCACTAGCCCTGACTTTTCTTTTCCCCTGGTACATTAATAACTTGAGTTATTAATGTTCTGGAGATGATGGTCGTGATGGTTGCCC...
GGAAATTAAGTTTGTTATTAAAAAATAATGCAGCTAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTCTGGAGGCCGAGATGGGAGGATTACTTGAGGCCAGGAGTTTGAGACAAGTTGGTCAACATAGTACAATCCTGTCTCTACAAAAAAATTTAGAAAATAATAATATTGCTATAAGGGCTGAGGATAATGGAGTTATTAATGGGTGTATTAATAACCGTAAAGTCACCGCACTAGCCCTGACTTTTCTTTTCCCCTGGTACATTAATAACTTGAGTTATTAATGTTCTGGAGATGATGGTCGTGATGGTTGCCC...
pathogenic
17,743
Clinical classification of chromosome 1, position 173825449, gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial): benign or pathogenic? Disease(s) if pathogenic?
benign
CATTGGGGGGTGGGGGGATGGGAGTGAAGAAAGTTCCAGTAGACAATTCTTTAAGAGGTTAAATGACAGCCCTATACCCAAACATGCACCCCCTACTCTAGACAGATGATCACTCTACTGTTCTCCCTGCCTTTTTATTCACCTTATCGCCAATTAAAAACACTTCTCTACTCCCGTTTGTCTCAGTAAATCTTATCCATTTTCCATGTGCCATCTCCTCAGAAGTTTTCCTGAGCTTGGCAGGGCTAGTTCTCTTGACAATTCCACTTGCAGTTGTGGTTCACAGCACACAAGTAAAGCTTTGTTGTTTCTCTTGTGAT...
CATTGGGGGGTGGGGGGATGGGAGTGAAGAAAGTTCCAGTAGACAATTCTTTAAGAGGTTAAATGACAGCCCTATACCCAAACATGCACCCCCTACTCTAGACAGATGATCACTCTACTGTTCTCCCTGCCTTTTTATTCACCTTATCGCCAATTAAAAACACTTCTCTACTCCCGTTTGTCTCAGTAAATCTTATCCATTTTCCATGTGCCATCTCCTCAGAAGTTTTCCTGAGCTTGGCAGGGCTAGTTCTCTTGACAATTCCACTTGCAGTTGTGGTTCACAGCACACAAGTAAAGCTTTGTTGTTTCTCTTGTGAT...
benign
17,822
Regarding the variant at chromosome 1 and position 173826717, affecting gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
AGTTGAAGGGCGCTTGGACCCCAGCGGCGATCTGTGTTTGGGTTCGCGCTCTGGGAGAATTTTGGCTTTGCTCGCCTTCCTCTTTCAGAAGACTCGAAATCGGCCAGCAGGTCTGCGAGATTTGAAACGCGACTGTTACTCCTTGTTTTCCGGTTCTGGCCGCGGGAGCCTCTCGAGAAGCGTGGAAAGAGGAGAAGGGCGTATACCTTGTGACCGCCTCTGGTTGTCTTGGGCTCGCGCCTGGCGCCGCTACGTGGAGTCGCTCTCTCGTCGTCACTTTTGGCTGCCGACTTGTTGAGTAGAAGTGCAGACTGATGCTT...
AGTTGAAGGGCGCTTGGACCCCAGCGGCGATCTGTGTTTGGGTTCGCGCTCTGGGAGAATTTTGGCTTTGCTCGCCTTCCTCTTTCAGAAGACTCGAAATCGGCCAGCAGGTCTGCGAGATTTGAAACGCGACTGTTACTCCTTGTTTTCCGGTTCTGGCCGCGGGAGCCTCTCGAGAAGCGTGGAAAGAGGAGAAGGGCGTATACCTTGTGACCGCCTCTGGTTGTCTTGGGCTCGCGCCTGGCGCCGCTACGTGGAGTCGCTCTCTCGTCGTCACTTTTGGCTGCCGACTTGTTGAGTAGAAGTGCAGACTGATGCTT...
pathogenic
17,825
Gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial) variant at chromosome 1, position 173828312—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
benign
GTTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGA...
GTTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGA...
benign
17,829
Variant chromosome 1, position 173828312, gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial): benign or pathogenic? Disease(s)?
pathogenic; ['Abnormal_foot_morphology', 'CNS_demyelination', 'Cerebral_cortical_atrophy', 'Clubfoot', 'Difficulty_walking', 'Dysmetria', 'EMG:_axonal_abnormality', 'Gait_ataxia', 'Gait_imbalance', 'Gout', 'Hypertensive_disorder', 'Impaired_vibration_sensation_in_the_lower_limbs', 'Leukoencephalopathy_with_brain_stem_a...
GTTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGA...
GTTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGA...
pathogenic
17,830
The mutation impacting DARS2 (aspartyl-tRNA synthetase 2, mitochondrial) on chromosome 1 at position 173828313: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
TTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGAC...
TTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGAC...
benign
17,832
Does the chromosome 1 mutation at position 173828313 within gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
TTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGAC...
TTTTCTAGTGTACAAGTGGCTGTTAAACACTAGATTCATACTAAAGCTAAATAGTTCCTACACCGTCCATTTCTGCAGTTTCTAAAATCCTATTTCATTTGAGGAAGAAATGTGCAATATTAAGAATTGGGTAATTAGGATTTTAGGTCAATGCAAATGCTAGAAGATCAAAAAAATTTTGATTTCCTAACACAAGACAGAAATTTACATTCAGTTATTCACTTGGCTTTTGACACATTTGCAGGTAAATTTAATAGTGAATGAATTAAATTACATACTCTGACTTATTTTATTTTATAAATTTCCCCTGTAGCCCTGAC...
benign
17,833
Does the genetic variant at chromosome 1, position 173833440, impacting gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
CACAGACATGTATGTTTTATACTATACACTATAAGGACTTTGCACATTTTACATATGTAAATAAATGCATAGATTCTACAAATGTGTATTTTGTGTATATCCTGATGAGTAATTTTTAAAACCCTTCCTTCTCACTCTCCAAGAAAATGCCAACAGGTGAGATTGAAATCAAAGTTAAAACAGCTGAGCTTCTGAATGCCTGCAAGAAGCTGCCCTTTGAAATTAAGAACTTCGTGAAGGTACCAACCTCTGTTATTAATAAAATAGAGTATCTAGAAAATGTTGATGACTAGTCAAGTATTTTCAGAGTTTTTTAAAGA...
CACAGACATGTATGTTTTATACTATACACTATAAGGACTTTGCACATTTTACATATGTAAATAAATGCATAGATTCTACAAATGTGTATTTTGTGTATATCCTGATGAGTAATTTTTAAAACCCTTCCTTCTCACTCTCCAAGAAAATGCCAACAGGTGAGATTGAAATCAAAGTTAAAACAGCTGAGCTTCTGAATGCCTGCAAGAAGCTGCCCTTTGAAATTAAGAACTTCGTGAAGGTACCAACCTCTGTTATTAATAAAATAGAGTATCTAGAAAATGTTGATGACTAGTCAAGTATTTTCAGAGTTTTTTAAAGA...
pathogenic
17,848
Variant in DARS2 (aspartyl-tRNA synthetase 2, mitochondrial), chromosome 1, position 173836919—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
TGGATCCAAGCGATTCTCATGGCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCATGCCCGGCTAACTTTTGTATTTACTTTAGTAGAGACGGAGTTTCACCGTTTTGGCCAGGCTGGTCTCGAACACCTGACCTGAAATGATCCGCACACCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTTACTCAGTCTCATTTGAGTTTTATAGATGTAATCATTAATAAATTGGTATTTTTTGTTTTTGTTTTTGTTTTTTTAGACAGTCTCGTTCTGTCACCTGAATCCGCCTACTGGATTCAA...
TGGATCCAAGCGATTCTCATGGCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCATGCCCGGCTAACTTTTGTATTTACTTTAGTAGAGACGGAGTTTCACCGTTTTGGCCAGGCTGGTCTCGAACACCTGACCTGAAATGATCCGCACACCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTTACTCAGTCTCATTTGAGTTTTATAGATGTAATCATTAATAAATTGGTATTTTTTGTTTTTGTTTTTGTTTTTTTAGACAGTCTCGTTCTGTCACCTGAATCCGCCTACTGGATTCAA...
benign
17,853
Gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial) variant at chromosome 1, position 173839470—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
TTTTTGAGGAAATATAGAAAACTTTGTGAGCTAGATCGTTGAGGACAGAGCTACATTTCAGCAGGTGAAGATGAGAGTTGGAATGGCATAGCACAGAAAGTCTCAAGTGTATCCATGGCACAGTAAAGATTTCACTTTGGCCAAAGCAAAAGAGTATATATGAAGAAGCATGGGCTAAAAAAAATGTTTTAATAAAAAGAGCTGGCATGGACTGATTTGCATGCTAGTCTAAATACATGAATATCCAGAGGTGCCAGTGTTTATTTTGAAAACAATATATAGAATAGTTAACTTCTCATAGGTCAGCTGTATGTCTAATT...
TTTTTGAGGAAATATAGAAAACTTTGTGAGCTAGATCGTTGAGGACAGAGCTACATTTCAGCAGGTGAAGATGAGAGTTGGAATGGCATAGCACAGAAAGTCTCAAGTGTATCCATGGCACAGTAAAGATTTCACTTTGGCCAAAGCAAAAGAGTATATATGAAGAAGCATGGGCTAAAAAAAATGTTTTAATAAAAAGAGCTGGCATGGACTGATTTGCATGCTAGTCTAAATACATGAATATCCAGAGGTGCCAGTGTTTATTTTGAAAACAATATATAGAATAGTTAACTTCTCATAGGTCAGCTGTATGTCTAATT...
pathogenic
17,862
Determine if the mutation at chromosome 1, position 173840925 in gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
AGATGCGTGCCACCATGCCCAGCTGATTTTTTGTGTTTTTATTAGAGATGGGGTTTGACCATGTTGGCCAGGATGGTCTGGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGTTTACAGGCGTGAGCCACCACGCCTGGCCAATAGCATTTTAATCATGTGTTGAAGTGAAAAAATTATGAGCTTTGGAGTTGGACAGACCTGGGATCAGATGTAGCTTCGCTGCTTACTAATTGCACATACGCAAATAAGTAACTTAGTTCTCTGAGCCTTCATGAAATGGTTGTGGGAACTAAGCAAGTTA...
AGATGCGTGCCACCATGCCCAGCTGATTTTTTGTGTTTTTATTAGAGATGGGGTTTGACCATGTTGGCCAGGATGGTCTGGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGTTTACAGGCGTGAGCCACCACGCCTGGCCAATAGCATTTTAATCATGTGTTGAAGTGAAAAAATTATGAGCTTTGGAGTTGGACAGACCTGGGATCAGATGTAGCTTCGCTGCTTACTAATTGCACATACGCAAATAAGTAACTTAGTTCTCTGAGCCTTCATGAAATGGTTGTGGGAACTAAGCAAGTTA...
pathogenic
17,865
Evaluate the clinical significance of the mutation at chromosome 1, position 173840937 in gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
CCATGCCCAGCTGATTTTTTGTGTTTTTATTAGAGATGGGGTTTGACCATGTTGGCCAGGATGGTCTGGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGTTTACAGGCGTGAGCCACCACGCCTGGCCAATAGCATTTTAATCATGTGTTGAAGTGAAAAAATTATGAGCTTTGGAGTTGGACAGACCTGGGATCAGATGTAGCTTCGCTGCTTACTAATTGCACATACGCAAATAAGTAACTTAGTTCTCTGAGCCTTCATGAAATGGTTGTGGGAACTAAGCAAGTTAATGTATGTAAGG...
CCATGCCCAGCTGATTTTTTGTGTTTTTATTAGAGATGGGGTTTGACCATGTTGGCCAGGATGGTCTGGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGTTTACAGGCGTGAGCCACCACGCCTGGCCAATAGCATTTTAATCATGTGTTGAAGTGAAAAAATTATGAGCTTTGGAGTTGGACAGACCTGGGATCAGATGTAGCTTCGCTGCTTACTAATTGCACATACGCAAATAAGTAACTTAGTTCTCTGAGCCTTCATGAAATGGTTGTGGGAACTAAGCAAGTTAATGTATGTAAGG...
pathogenic
17,866
Is the variant located on chromosome 1 at position 173845271, gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
CATACAAAGAAAATTTTTTCTTAGGTTCACAATGCTTAAAAGAGAGAGAGAATAAGGGCCAAGCGTGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCACGTCTGTACTAAAAATGTAAAAAATTAGCCAGGTGTGGTTGTGCGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGAAGAATCGCTTGAACCCCGGAGGCGGAGGTTGCCGTGATCTGAGATTGCCTCACTGCACTCCAGCCTGGGCAACA...
CATACAAAGAAAATTTTTTCTTAGGTTCACAATGCTTAAAAGAGAGAGAGAATAAGGGCCAAGCGTGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCACGTCTGTACTAAAAATGTAAAAAATTAGCCAGGTGTGGTTGTGCGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGAAGAATCGCTTGAACCCCGGAGGCGGAGGTTGCCGTGATCTGAGATTGCCTCACTGCACTCCAGCCTGGGCAACA...
pathogenic
17,870
Variant chromosome 1, position 173853398, gene DARS2 (aspartyl-tRNA synthetase 2, mitochondrial): benign or pathogenic? Disease(s)?
pathogenic; ['Leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement-high_lactate_syndrome']
AGGGGTAGTGAAATTAGTCATATAACCATGAAAAAATATTTTCAGTGTCAAGATTTCACAAATGAAGAAAATTAGGAGTCTCAAATTTTTATACATCATGCATTCGTAAATTGTGGAGGGACGGATCAGACCACTGGCGAGCTGGAGGGCTGGCAGACACCCCTGGACCAACTTGGTCAAAGTGGGACCCTTTTTCCTCAAGAACAGCAGCTGTAGGTGATGAGTGCCATCATGCACTGGCTGAGTCATGATTCTTCAGGGGATATGGAAGACTGAATTAGCTTTAGGGATCTTTGTAAAATATAGAAAAGTATAGTACA...
AGGGGTAGTGAAATTAGTCATATAACCATGAAAAAATATTTTCAGTGTCAAGATTTCACAAATGAAGAAAATTAGGAGTCTCAAATTTTTATACATCATGCATTCGTAAATTGTGGAGGGACGGATCAGACCACTGGCGAGCTGGAGGGCTGGCAGACACCCCTGGACCAACTTGGTCAAAGTGGGACCCTTTTTCCTCAAGAACAGCAGCTGTAGGTGATGAGTGCCATCATGCACTGGCTGAGTCATGATTCTTCAGGGGATATGGAAGACTGAATTAGCTTTAGGGATCTTTGTAAAATATAGAAAAGTATAGTACA...
pathogenic
17,873
Does the variant on chromosome 1 at location 173909873 affecting gene SERPINC1 (serpin family C member 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Hereditary_antithrombin_deficiency']
ACAAAAATTAGCCAGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGAAGACTGAGGCAGGAGAATCGCTTGAACTCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCAACAAGAGCAAAACTGCATCTCAAAAATAATAATAATAATAATAATAATAATAATAATAATAATAATAAAAGTACTTTGGGCTTGTTCAGCATGGCTCCTGATAATTCATTCTCAGGCTTCAGCTTTTTGTGGGAGAGAGAAACGGCAAGACTCTGTTCTTACAGAAAAAACTCACTCCATCCAG...
ACAAAAATTAGCCAGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGAAGACTGAGGCAGGAGAATCGCTTGAACTCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCAACAAGAGCAAAACTGCATCTCAAAAATAATAATAATAATAATAATAATAATAATAATAATAATAATAAAAGTACTTTGGGCTTGTTCAGCATGGCTCCTGATAATTCATTCTCAGGCTTCAGCTTTTTGTGGGAGAGAGAAACGGCAAGACTCTGTTCTTACAGAAAAAACTCACTCCATCCAG...
pathogenic
17,912
Gene SERPINC1 (serpin family C member 1) variant at chromosome position 173911958 on chromosome 1: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Hereditary_antithrombin_deficiency']
GTTCTCAGGGCTGAACTTTGACTTCCACAGGCCCTGGAAGAGAATCACAAAGTAAGAACACAAACATTCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAA...
GTTCTCAGGGCTGAACTTTGACTTCCACAGGCCCTGGAAGAGAATCACAAAGTAAGAACACAAACATTCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAA...
pathogenic
17,926
A genetic variant at chromosome 1, position 173911974, affecting gene SERPINC1 (serpin family C member 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Hereditary_antithrombin_deficiency']
TTTGACTTCCACAGGCCCTGGAAGAGAATCACAAAGTAAGAACACAAACATTCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAATGAGTGACAAAGCCAC...
TTTGACTTCCACAGGCCCTGGAAGAGAATCACAAAGTAAGAACACAAACATTCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAATGAGTGACAAAGCCAC...
pathogenic
17,928
Is the chromosome 1, position 173912025 variant in SERPINC1 (serpin family C member 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
TCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAATGAGTGACAAAGCCACGAAAACACAAAGGAACAGTAAATGCATTTTACTAGGTGAAAGAAGCCAATC...
TCATAGGAGGATAGTTATTGACACAAGACATATCCATATTATAGTGTTACATTAATATATAATTATTCGGAAAAAAGACTGGCGGGATATGCACAAAAAGGTTAACAATGGCTGTGTCAGAATGATGGAATTATGAGTAGGTTTATTCATAACTGTCAAACCTTGGAAGCAGCCAAAATGTCCTTCAGTAGATGAATAGACAGACTGTGGTACATCCAGACCAAATGTAATGCTATTCCATGCTAAGAAGAAATGAGTGACAAAGCCACGAAAACACAAAGGAACAGTAAATGCATTTTACTAGGTGAAAGAAGCCAATC...
benign
17,931
Chromosome 1, position 173914677, gene SERPINC1 (serpin family C member 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Hereditary_antithrombin_deficiency']
TTTTGGTTTTATCTGTTCTCTGCCTTTGGTTTTCCTGATTTTGCTCCAATAGGCACTTTTTTTAGGGGGGGATTATGCTTTTGATCAAAAGCTTGGTGCTGAATCTCTCTTTTCTCCAGAGAGATTCAGTCTCACCCTGCTTTCCCAACACATGGCGTTTGTGTAGAGGGGAGGACCAAAGGAACATGTGTGGTTTGGAAGCAGTGTTCTGTTCTGTTCTTCTTGTAGGAAGGGTTACATTTAAGATCTTACCTGGGGACAGAGACATGAGTGATATGGAAGTACTTTGAGACCAGTACCAATGTATACAAAAATGACTG...
TTTTGGTTTTATCTGTTCTCTGCCTTTGGTTTTCCTGATTTTGCTCCAATAGGCACTTTTTTTAGGGGGGGATTATGCTTTTGATCAAAAGCTTGGTGCTGAATCTCTCTTTTCTCCAGAGAGATTCAGTCTCACCCTGCTTTCCCAACACATGGCGTTTGTGTAGAGGGGAGGACCAAAGGAACATGTGTGGTTTGGAAGCAGTGTTCTGTTCTGTTCTTCTTGTAGGAAGGGTTACATTTAAGATCTTACCTGGGGACAGAGACATGAGTGATATGGAAGTACTTTGAGACCAGTACCAATGTATACAAAAATGACTG...
pathogenic
17,935
Considering the genetic mutation at chromosome 1, position 173914683, impacting SERPINC1 (serpin family C member 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['SERPINC1-related_disorder']
TTTTATCTGTTCTCTGCCTTTGGTTTTCCTGATTTTGCTCCAATAGGCACTTTTTTTAGGGGGGGATTATGCTTTTGATCAAAAGCTTGGTGCTGAATCTCTCTTTTCTCCAGAGAGATTCAGTCTCACCCTGCTTTCCCAACACATGGCGTTTGTGTAGAGGGGAGGACCAAAGGAACATGTGTGGTTTGGAAGCAGTGTTCTGTTCTGTTCTTCTTGTAGGAAGGGTTACATTTAAGATCTTACCTGGGGACAGAGACATGAGTGATATGGAAGTACTTTGAGACCAGTACCAATGTATACAAAAATGACTGAAGGGC...
TTTTATCTGTTCTCTGCCTTTGGTTTTCCTGATTTTGCTCCAATAGGCACTTTTTTTAGGGGGGGATTATGCTTTTGATCAAAAGCTTGGTGCTGAATCTCTCTTTTCTCCAGAGAGATTCAGTCTCACCCTGCTTTCCCAACACATGGCGTTTGTGTAGAGGGGAGGACCAAAGGAACATGTGTGGTTTGGAAGCAGTGTTCTGTTCTGTTCTTCTTGTAGGAAGGGTTACATTTAAGATCTTACCTGGGGACAGAGACATGAGTGATATGGAAGTACTTTGAGACCAGTACCAATGTATACAAAAATGACTGAAGGGC...
pathogenic
17,936
Located at chromosome 1 position 179551292, the variant affecting gene NPHS2—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Nephrotic_syndrome,_type_2', 'Steroid-resistant_nephrotic_syndrome']
CCAGTTTCTGAAGAATTTTACCTTTGACTATCCACTATACTCTTTCACCTAAACACAGTTTTATAGCAACTTATCGCTATGATTTCCTTCTTATCAAGCCCACCAACTGCAACAGTTGGTTAATTTGAAAGACAACGCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAG...
CCAGTTTCTGAAGAATTTTACCTTTGACTATCCACTATACTCTTTCACCTAAACACAGTTTTATAGCAACTTATCGCTATGATTTCCTTCTTATCAAGCCCACCAACTGCAACAGTTGGTTAATTTGAAAGACAACGCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAG...
pathogenic
18,011
Evaluate this variant at chromosome 1, position 179551376, gene NPHS2: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Nephrotic_syndrome,_type_2', 'Steroid-resistant_nephrotic_syndrome']
TCCTTCTTATCAAGCCCACCAACTGCAACAGTTGGTTAATTTGAAAGACAACGCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAGCCATTTTTACCCTGGTGTTCACTTCTGCTTGTTCTGCTTTTGGCTTCTGTTATGCCTGACCCAGCATGACTCTACCTTCTTCTT...
TCCTTCTTATCAAGCCCACCAACTGCAACAGTTGGTTAATTTGAAAGACAACGCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAGCCATTTTTACCCTGGTGTTCACTTCTGCTTGTTCTGCTTTTGGCTTCTGTTATGCCTGACCCAGCATGACTCTACCTTCTTCTT...
pathogenic
18,014
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 179551428, gene NPHS2: what disease(s) if pathogenic?
pathogenic; ['Nephrotic_syndrome,_type_2']
GCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAGCCATTTTTACCCTGGTGTTCACTTCTGCTTGTTCTGCTTTTGGCTTCTGTTATGCCTGACCCAGCATGACTCTACCTTCTTCTTCATTACACATGCCAAAATTTGCTATCCTGAGATCAGGAACCGTCATATATGG...
GCATGCCAGCAAGCAGACCTGAAAGCCCTCTGGCATGCCAATGAGAAATTTAAATATTGACCTGTGCCAGACATCAGAGGAAACCAAACAATAGGAGATACCATAGGCACTCCCCAGATATGCAAGCAAAATCTGCCTTTGACAAAAAACCAGTGTTATAAGGAAGTATGAAGAGTCATAAAAGCCATTTTTACCCTGGTGTTCACTTCTGCTTGTTCTGCTTTTGGCTTCTGTTATGCCTGACCCAGCATGACTCTACCTTCTTCTTCATTACACATGCCAAAATTTGCTATCCTGAGATCAGGAACCGTCATATATGG...
pathogenic
18,016
Variant at chromosome position 179552619, chromosome 1, gene NPHS2: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Chronic_kidney_disease', 'Focal_segmental_glomerulosclerosis', 'NPHS2-related_disorder', 'Nephrotic_range_proteinuria', 'Nephrotic_syndrome,_type_2', 'Steroid-resistant_nephrotic_syndrome']
GTATATCCGACTCCAAGTACATCTCTCTTTTTTGCATTCACTCTGAAACATTTAAGTGTCACTTTAGGTAACTATCAGGGTTAGGTGTGAGGAATTCAGGGTGGAGCAAAAAGATTGAGTGTGGTTGAGGAAAACTAAGACTTGGTAGTATCATTGGAGAGAAGACTGCATCTTTGGGACAGAAGAGCAATAGAGTGTGACAAGCCCAATGATAGGTGCTTGTAGGAAGGGCTGTGGGAGCTGTGGCAACCTTGCCAAAGGGGTCAGAGGACATACAGTGAAAGGGACATCTGAACCAAGTTCCCAGAAGTCAAAATTTA...
GTATATCCGACTCCAAGTACATCTCTCTTTTTTGCATTCACTCTGAAACATTTAAGTGTCACTTTAGGTAACTATCAGGGTTAGGTGTGAGGAATTCAGGGTGGAGCAAAAAGATTGAGTGTGGTTGAGGAAAACTAAGACTTGGTAGTATCATTGGAGAGAAGACTGCATCTTTGGGACAGAAGAGCAATAGAGTGTGACAAGCCCAATGATAGGTGCTTGTAGGAAGGGCTGTGGGAGCTGTGGCAACCTTGCCAAAGGGGTCAGAGGACATACAGTGAAAGGGACATCTGAACCAAGTTCCCAGAAGTCAAAATTTA...
pathogenic
18,034
Is chromosome 1, position 179559729, gene NPHS2 (NPHS2 stomatin family member, podocin) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Nephrotic_syndrome,_type_2']
TATTTTAAGGATTTAGCTATAAGGATGTTACTCACAGTATTGCTAATTGGAATACAAATTGGAAAGAATTTAACATCAACAATAGGGAATTGGTTGAGTAAATTGTGATACAGCCACTAAATGAAATGCTGTATGTCCATTTAAAATAAAGAGATAGAAGCATTTAGCTAATATATGAAAAGATGATCACAATATATTGTTGGGTTAAGAAAGACACATTACAAAACAGTATATATGGTATGATATATGTGTGTATATATATATACCCATCTGTAAATATAACCACATACACTGAAAAATCTGAAAGGATATACTCCAAA...
TATTTTAAGGATTTAGCTATAAGGATGTTACTCACAGTATTGCTAATTGGAATACAAATTGGAAAGAATTTAACATCAACAATAGGGAATTGGTTGAGTAAATTGTGATACAGCCACTAAATGAAATGCTGTATGTCCATTTAAAATAAAGAGATAGAAGCATTTAGCTAATATATGAAAAGATGATCACAATATATTGTTGGGTTAAGAAAGACACATTACAAAACAGTATATATGGTATGATATATGTGTGTATATATATATACCCATCTGTAAATATAACCACATACACTGAAAAATCTGAAAGGATATACTCCAAA...
pathogenic
18,061
Variant in NPHS2 (NPHS2 stomatin family member, podocin), chromosome 1, position 179559760—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Nephrotic_syndrome,_type_2', 'Steroid-resistant_nephrotic_syndrome']
TCACAGTATTGCTAATTGGAATACAAATTGGAAAGAATTTAACATCAACAATAGGGAATTGGTTGAGTAAATTGTGATACAGCCACTAAATGAAATGCTGTATGTCCATTTAAAATAAAGAGATAGAAGCATTTAGCTAATATATGAAAAGATGATCACAATATATTGTTGGGTTAAGAAAGACACATTACAAAACAGTATATATGGTATGATATATGTGTGTATATATATATACCCATCTGTAAATATAACCACATACACTGAAAAATCTGAAAGGATATACTCCAAAATATCAACAGTTAACTATGGGTAACAGGATT...
TCACAGTATTGCTAATTGGAATACAAATTGGAAAGAATTTAACATCAACAATAGGGAATTGGTTGAGTAAATTGTGATACAGCCACTAAATGAAATGCTGTATGTCCATTTAAAATAAAGAGATAGAAGCATTTAGCTAATATATGAAAAGATGATCACAATATATTGTTGGGTTAAGAAAGACACATTACAAAACAGTATATATGGTATGATATATGTGTGTATATATATATACCCATCTGTAAATATAACCACATACACTGAAAAATCTGAAAGGATATACTCCAAAATATCAACAGTTAACTATGGGTAACAGGATT...
pathogenic
18,063
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 179561279, gene NPHS2 (NPHS2 stomatin family member, podocin): what disease(s) if pathogenic?
benign
GTAATCTGCTTTACTCAACGTCTGCTGATTTAAATGTTAATCCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAG...
GTAATCTGCTTTACTCAACGTCTGCTGATTTAAATGTTAATCCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAG...
benign
18,069
A genetic alteration at chromosome 1, position 179561303, in gene NPHS2 (NPHS2 stomatin family member, podocin)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Nephrotic_syndrome,_type_2']
CTGATTTAAATGTTAATCCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATA...
CTGATTTAAATGTTAATCCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATA...
pathogenic
18,072
Variant in gene NPHS2 (NPHS2 stomatin family member, podocin), located at chromosome 1 position 179561320: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['NPHS2-related_disorder', 'Nephrotic_syndrome', 'Nephrotic_syndrome,_type_2', 'Steroid-resistant_nephrotic_syndrome']
CCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATATCATTATTTTTCTTTCC...
CCCATCTAAAAAAGTACCTTCACAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATATCATTATTTTTCTTTCC...
pathogenic
18,073
Does the variant impacting NPHS2 (NPHS2 stomatin family member, podocin) on chromosome 1, position 179561342, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Nephrotic_syndrome', 'Nephrotic_syndrome,_type_2']
CAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATATCATTATTTTTCTTTCCTATTTTTGAGTATAAATAATCA...
CAGTAACATCCAGATGTGTTTGGCCAAATATAGGTCAAATGATCATGGCCTAGCCAGGCTGACACATAAGGTTAACTATCACAAAGTTCTTTGCCCATTTTTAAAATCAGGTTGTTTACTTTTTTTGTTGTTGAGATGTATGAGTTCTTCATATATATTGAATATTAACCCTTTATGAGATATGATTTGCAAATATTTTCCCCCATTCCCTAGATTGCCTTTGCACTCTGTTAATTGTGTCCTTTGATGCACAAAAGTTTTAAGTTATGATGTAGTCCATATCATTATTTTTCTTTCCTATTTTTGAGTATAAATAATCA...
pathogenic
18,076
Variant on chromosome 1, at position 179564688, affecting NPHS2 (NPHS2 stomatin family member, podocin): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Nephrotic_syndrome,_type_2']
TAAGTCCTTTGAGGCTGGGAACCATGTTTTGTTTGTCTTCATGAGGTTTACAATTTTATGAGGCCAGAACACTGCCTTGCTTGAAACAATCAGAATGAATGACTGTATGTGGTTCTTAGAGCATGCCAAGCAATTCCCAATTGCTTGGTTTCCTAGCATTACTTGTTTCTTACCTGCTTTTATTGGAAAAAACAAATTCTCCCCAGAGATGAAGGGGAGTCTTATTTCTTCAAGACCTTGCTCAAATATAACTGCCTGGTTCTGCTTTTGTTTCCTCTCCCTAATTGGCTTCTTAGGGCTTACCATCTTAAGTGACCAGA...
TAAGTCCTTTGAGGCTGGGAACCATGTTTTGTTTGTCTTCATGAGGTTTACAATTTTATGAGGCCAGAACACTGCCTTGCTTGAAACAATCAGAATGAATGACTGTATGTGGTTCTTAGAGCATGCCAAGCAATTCCCAATTGCTTGGTTTCCTAGCATTACTTGTTTCTTACCTGCTTTTATTGGAAAAAACAAATTCTCCCCAGAGATGAAGGGGAGTCTTATTTCTTCAAGACCTTGCTCAAATATAACTGCCTGGTTCTGCTTTTGTTTCCTCTCCCTAATTGGCTTCTTAGGGCTTACCATCTTAAGTGACCAGA...
pathogenic
18,078
Is the chromosome 1, position 179564773 variant in NPHS2 (NPHS2 stomatin family member, podocin) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['NPHS2-related_disorder', 'Nephrotic_syndrome,_type_2']
ACAATCAGAATGAATGACTGTATGTGGTTCTTAGAGCATGCCAAGCAATTCCCAATTGCTTGGTTTCCTAGCATTACTTGTTTCTTACCTGCTTTTATTGGAAAAAACAAATTCTCCCCAGAGATGAAGGGGAGTCTTATTTCTTCAAGACCTTGCTCAAATATAACTGCCTGGTTCTGCTTTTGTTTCCTCTCCCTAATTGGCTTCTTAGGGCTTACCATCTTAAGTGACCAGATCTGAGAGCCTTTCCCAAAAACCATGGCTGAGTCAGTGTTGTATCTTGTGGCAGTCATGCAGGTGCTCAGGTCACCCTTTGAGAA...
ACAATCAGAATGAATGACTGTATGTGGTTCTTAGAGCATGCCAAGCAATTCCCAATTGCTTGGTTTCCTAGCATTACTTGTTTCTTACCTGCTTTTATTGGAAAAAACAAATTCTCCCCAGAGATGAAGGGGAGTCTTATTTCTTCAAGACCTTGCTCAAATATAACTGCCTGGTTCTGCTTTTGTTTCCTCTCCCTAATTGGCTTCTTAGGGCTTACCATCTTAAGTGACCAGATCTGAGAGCCTTTCCCAAAAACCATGGCTGAGTCAGTGTTGTATCTTGTGGCAGTCATGCAGGTGCTCAGGTCACCCTTTGAGAA...
pathogenic
18,083
The mutation in gene NPHS2 (NPHS2 stomatin family member, podocin) at chromosome 1, position 179575708—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Nephrotic_syndrome,_type_2']
TTCATAAATATGTTTCAGTTACCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTT...
TTCATAAATATGTTTCAGTTACCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTT...
pathogenic
18,092
Clinical classification of chromosome 1, position 179575722, gene NPHS2 (NPHS2 stomatin family member, podocin): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Nephrotic_syndrome,_type_2']
TCAGTTACCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTC...
TCAGTTACCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTC...
pathogenic
18,094
Gene NPHS2 (NPHS2 stomatin family member, podocin) variant at chromosome 1, position 179575729—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Nephrotic_syndrome,_type_2']
CCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTA...
CCAGTGGTAGCCATGGCAAGTAAAAATAAATAAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTA...
pathogenic
18,096
Classify the chromosome 1 variant at position 179575760 affecting gene NPHS2 (NPHS2 stomatin family member, podocin) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Nephrotic_syndrome,_type_2']
AAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAA...
AAATGCATATACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAA...
pathogenic
18,098
Does the genetic variant at chromosome 1, position 179575769, impacting gene NPHS2 (NPHS2 stomatin family member, podocin), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Nephrotic_syndrome,_type_2']
TACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAAAAAGAGGAG...
TACAAAATTACATTTTATAAATGAAGAAAGGCCTCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAAAAAGAGGAG...
pathogenic
18,100
Evaluate this variant at chromosome 1, position 179575802, gene NPHS2 (NPHS2 stomatin family member, podocin): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Nephrotic_syndrome,_type_2']
TCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAAAAAGAGGAGGGGATGTTACTCTCTGTTCCCCGTGAGCTTCAG...
TCAAAAATTCCTTCATACAGTAGCGAGAGATATGCGTAGAAAACTAATTTATATCCTCAAACCTAACGTGAAGATTTACCCCCAAAATATTATTCTGTTAGAATAAGTTGCTTGAATATCCAACTTGTTTGGTTTAAGTGAATAGTGAAACATTAATTATTCAAGCAGGAAAACCTTTAAACATTGTCTGAGAGTCCCCAACATTTTGGTGAGGTGAAGCGCCTTTTCATTTCTCCCGTCTTAAGTAGCCTGCCTTTGGGAGTGTGGTGCTAGGTGAAAAAGAGGAGGGGATGTTACTCTCTGTTCCCCGTGAGCTTCAG...
pathogenic
18,101
Is the genetic mutation found on chromosome 1 at position 180271949, within the gene LHX4, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
GGCTTCAGGGAGGGAGTTGGGCCACAGTAGTTCCGGGATGACAGTGGCCACGTGAGAGAAGAAAACAGCCCGAGGAGAAGGGAAGGCACGGGTGTGTCCCCCCTCACTGTGTACACACATGTCCTGGCTGCACAGCTGCTTCATTCCTCTAGTGCCTCCCAAGATCAGGGCAGGCCGTGTTGCCCTCTGGACTTCCAAGGGGGAAGTGAGTTACTGGCCCAAGTCACTCACTCATCAAGAACACTGAAGCCAGGTCTGCTGACTCCAGGGAGAGCCTTGTAGATTGTGAGGACCGAATGCATATAAAGTCCTTAGTCAAC...
GGCTTCAGGGAGGGAGTTGGGCCACAGTAGTTCCGGGATGACAGTGGCCACGTGAGAGAAGAAAACAGCCCGAGGAGAAGGGAAGGCACGGGTGTGTCCCCCCTCACTGTGTACACACATGTCCTGGCTGCACAGCTGCTTCATTCCTCTAGTGCCTCCCAAGATCAGGGCAGGCCGTGTTGCCCTCTGGACTTCCAAGGGGGAAGTGAGTTACTGGCCCAAGTCACTCACTCATCAAGAACACTGAAGCCAGGTCTGCTGACTCCAGGGAGAGCCTTGTAGATTGTGAGGACCGAATGCATATAAAGTCCTTAGTCAAC...
benign
18,171
Chromosome 1, position 180787871, gene XPR1 (xenotropic and polytropic retrovirus receptor 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
ATAATTAGATAATTAAGTAGAATAAGCTGTTACTCTTATTTTATATCAGCTATAGCTAGATGTTAGTTATTATAAGAGCTGCATCTGTTACCATAGAGCTTCCTTAACGCAAACTCAGCTTTAAAAAAAAAAAAAAGCAAGGGAAAAAGAAAAAGAGAAAGCTGTGACCTGCTTCATGCTTTGAAAAAAATAATTCCCGGTGACCTTGGGCAGCTATAGCCCTTATTGTACCTAGATTGCGGAGTTTAAAGTGGCCATCCTGTTTTACTCTAGAATCAATACAACATCCTGCATTATCTGATCAGGTCTAAAGCACATGA...
ATAATTAGATAATTAAGTAGAATAAGCTGTTACTCTTATTTTATATCAGCTATAGCTAGATGTTAGTTATTATAAGAGCTGCATCTGTTACCATAGAGCTTCCTTAACGCAAACTCAGCTTTAAAAAAAAAAAAAAGCAAGGGAAAAAGAAAAAGAGAAAGCTGTGACCTGCTTCATGCTTTGAAAAAAATAATTCCCGGTGACCTTGGGCAGCTATAGCCCTTATTGTACCTAGATTGCGGAGTTTAAAGTGGCCATCCTGTTTTACTCTAGAATCAATACAACATCCTGCATTATCTGATCAGGTCTAAAGCACATGA...
benign
18,187
Determine if the mutation at chromosome 1, position 181732587 in gene CACNA1E (calcium voltage-gated channel subunit alpha1 E) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
AGGGTCTATGGCCAGGGCCTCTGCGTTGCTCAAAGGCAGAGGTCACTGCTCACATCCTGGAGTACATGGATGGTGGCCTACGGAAAGATGGTGCTGCCTCTGACCATGGACCACTTCGTAGCCTTGACATCGTGCATGGCAGAGCACTTGCTCCGCTGCATGTTTTGTGAAGCTGGGTCAGGTTCTGCTATGGGAGTCATGAGCTGGGGAGCCACACCCAATGAATGTGCTATGCTAGCCCTAGAAATGACTCGGGGGAGGGGAAGAAAACTACTCAGCAACATCTACAGGATTTCCAAAATAGGAATCTGAAGGATGTG...
AGGGTCTATGGCCAGGGCCTCTGCGTTGCTCAAAGGCAGAGGTCACTGCTCACATCCTGGAGTACATGGATGGTGGCCTACGGAAAGATGGTGCTGCCTCTGACCATGGACCACTTCGTAGCCTTGACATCGTGCATGGCAGAGCACTTGCTCCGCTGCATGTTTTGTGAAGCTGGGTCAGGTTCTGCTATGGGAGTCATGAGCTGGGGAGCCACACCCAATGAATGTGCTATGCTAGCCCTAGAAATGACTCGGGGGAGGGGAAGAAAACTACTCAGCAACATCTACAGGATTTCCAAAATAGGAATCTGAAGGATGTG...
benign
18,296
Is the genetic change at chromosome 1, position 181771283, within gene CACNA1E (calcium voltage-gated channel subunit alpha1 E) benign or pathogenic? Name the disease(s) if pathogenic.
benign
TGGATTTAAATCTATACTCTCATGAGATTTTTCTATGAGGCCTCAGCATCCCTTCTTTCTCTTCCATACCCTGTTGATGGAGGTTTAAGTTAGTGACAAGGACTAAGTGAAAAGTTGAAAAAAAAAAAAAAGTACAAAAAATTTAAGAACATCTTCACAATAAATATGTGTTTTTGACTTAAATTATGTTTGTTTTGTTCTGCTTTTTGGTTTTTTTTTTTTGTAAAGATGAGGTCTCACTGTGTTGCCCAGGCTTGTCTTGAACTCCTGGGCTCAAGCAGTCCTCTCACCTCAGCCCCACAAAGTGCTGGGATTACAGG...
TGGATTTAAATCTATACTCTCATGAGATTTTTCTATGAGGCCTCAGCATCCCTTCTTTCTCTTCCATACCCTGTTGATGGAGGTTTAAGTTAGTGACAAGGACTAAGTGAAAAGTTGAAAAAAAAAAAAAAGTACAAAAAATTTAAGAACATCTTCACAATAAATATGTGTTTTTGACTTAAATTATGTTTGTTTTGTTCTGCTTTTTGGTTTTTTTTTTTTGTAAAGATGAGGTCTCACTGTGTTGCCCAGGCTTGTCTTGAACTCCTGGGCTCAAGCAGTCCTCTCACCTCAGCCCCACAAAGTGCTGGGATTACAGG...
benign
18,392
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 1, position 181776085, gene CACNA1E (calcium voltage-gated channel subunit alpha1 E). What disease(s) is it linked to if pathogenic?
benign
TGCCCGAGGCCTTGTGCTGGAAGCTAAGAACAAAAAATGTGAATCCAAAGCAATTCTGTCCTTGAAGGGTGATGGTAATTAAACCTGCCTCACAAAGAGTTGGAGCAAGCGTAACAACAAGTAATAGGTGTGACTGCACACGCTACACTCTTAATGACTGTTCAAATGAAAGGCAGTAACAGTGCTAACAGTTTTCATTGACATTAATAATAGGTACCCCGAAAAGTATACAAAAGAAATGTCTGGATACATGGAAAACCCTTTCTGTCTCTTGTAAGTGAAAGGGTCCTGCCTGATAGGTAGTAGTTGAACAAGTTCAC...
TGCCCGAGGCCTTGTGCTGGAAGCTAAGAACAAAAAATGTGAATCCAAAGCAATTCTGTCCTTGAAGGGTGATGGTAATTAAACCTGCCTCACAAAGAGTTGGAGCAAGCGTAACAACAAGTAATAGGTGTGACTGCACACGCTACACTCTTAATGACTGTTCAAATGAAAGGCAGTAACAGTGCTAACAGTTTTCATTGACATTAATAATAGGTACCCCGAAAAGTATACAAAAGAAATGTCTGGATACATGGAAAACCCTTTCTGTCTCTTGTAAGTGAAAGGGTCCTGCCTGATAGGTAGTAGTTGAACAAGTTCAC...
benign
18,398
Variant in gene CACNA1E (calcium voltage-gated channel subunit alpha1 E), located at chromosome 1 position 181783787: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
TTTTTATGTGATATTTTGTGTTTCTACAACTGTGTGGCTTCTTGTGAGTGAGTTACCTGACAAGCAGTGTTAAGTGGTGTGTTTCCTTTTAGAGGAGGCAGAGTGGTGGCCTGTGGGATGGCATATATGGGCAAGAAGGAAGCCTACAGCAAAACAGCTATCAGTGCTCATATGCAAAGAAATATCTTCAATCAGATAAGGAAATCATGCAGAAATTCCTTTAAACGTGGAATTGTTAGGAGAAAGGAAAATTCCTTTAAACAAGAAATTTTTAGGAGAGAGGAAAACTCATAACAAATGTTTTCACCCATGACATAGGA...
TTTTTATGTGATATTTTGTGTTTCTACAACTGTGTGGCTTCTTGTGAGTGAGTTACCTGACAAGCAGTGTTAAGTGGTGTGTTTCCTTTTAGAGGAGGCAGAGTGGTGGCCTGTGGGATGGCATATATGGGCAAGAAGGAAGCCTACAGCAAAACAGCTATCAGTGCTCATATGCAAAGAAATATCTTCAATCAGATAAGGAAATCATGCAGAAATTCCTTTAAACGTGGAATTGTTAGGAGAAAGGAAAATTCCTTTAAACAAGAAATTTTTAGGAGAGAGGAAAACTCATAACAAATGTTTTCACCCATGACATAGGA...
benign
18,409
Variant in gene LAMC2 (laminin subunit gamma 2), located at chromosome 1 position 183207931: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
GCAAAAACACATGATGAAAATTACAGAAAGAGAGGTAGATTTAAAACACCATATAAAAATGTTACTGTTTGTAACAACCAAGCTGAATGACCCTCTATTAGGGATTTATAAAAAGAATGTCTACATGCAATGGTAAACTCAATCTTGAGAAGGAACATAAAATGGAAAGATGAGGGCTTTGGAGTCAGACACATCTGGGAGCAAATTACATCTTTGCCATTTAGCTGTGTGACTTTAGGCAAGATACCTAGCCTCTCTGAGTATTTGTTTTTCCATCTATTAAATGGGGATAATAAAACCCATGTTAAAATGTTGTGAGA...
GCAAAAACACATGATGAAAATTACAGAAAGAGAGGTAGATTTAAAACACCATATAAAAATGTTACTGTTTGTAACAACCAAGCTGAATGACCCTCTATTAGGGATTTATAAAAAGAATGTCTACATGCAATGGTAAACTCAATCTTGAGAAGGAACATAAAATGGAAAGATGAGGGCTTTGGAGTCAGACACATCTGGGAGCAAATTACATCTTTGCCATTTAGCTGTGTGACTTTAGGCAAGATACCTAGCCTCTCTGAGTATTTGTTTTTCCATCTATTAAATGGGGATAATAAAACCCATGTTAAAATGTTGTGAGA...
pathogenic
18,584
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 183207945, gene LAMC2 (laminin subunit gamma 2): what disease(s) if pathogenic?
pathogenic; ['Epidermolysis_bullosa,_junctional_3A,_intermediate', 'Epidermolysis_bullosa,_junctional_3B,_severe', 'Junctional_epidermolysis_bullosa_gravis_of_Herlitz', 'LAMC2-related_disorder']
TGAAAATTACAGAAAGAGAGGTAGATTTAAAACACCATATAAAAATGTTACTGTTTGTAACAACCAAGCTGAATGACCCTCTATTAGGGATTTATAAAAAGAATGTCTACATGCAATGGTAAACTCAATCTTGAGAAGGAACATAAAATGGAAAGATGAGGGCTTTGGAGTCAGACACATCTGGGAGCAAATTACATCTTTGCCATTTAGCTGTGTGACTTTAGGCAAGATACCTAGCCTCTCTGAGTATTTGTTTTTCCATCTATTAAATGGGGATAATAAAACCCATGTTAAAATGTTGTGAGAATTAACTGAGCTGT...
TGAAAATTACAGAAAGAGAGGTAGATTTAAAACACCATATAAAAATGTTACTGTTTGTAACAACCAAGCTGAATGACCCTCTATTAGGGATTTATAAAAAGAATGTCTACATGCAATGGTAAACTCAATCTTGAGAAGGAACATAAAATGGAAAGATGAGGGCTTTGGAGTCAGACACATCTGGGAGCAAATTACATCTTTGCCATTTAGCTGTGTGACTTTAGGCAAGATACCTAGCCTCTCTGAGTATTTGTTTTTCCATCTATTAAATGGGGATAATAAAACCCATGTTAAAATGTTGTGAGAATTAACTGAGCTGT...
pathogenic
18,586
Benign or pathogenic: chromosome 1, position 183220852, gene LAMC2 (laminin subunit gamma 2) variant? Disease(s) if pathogenic?
pathogenic; ['Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
GCAGTAATCAATAGTGAGATCCTGGGACACAGGCTGGTTGCAGGAAAGGCCTGGCCTAATTAAACATGCTGCGAAAATTCTTGTAAGAGGGCCTATCACAGCATATGGCCATATATAACCATCGTGTACAGAAGAGGCACTGCCCTGGGGATAGGATGGCAGTTACATGCACACACATGAATGGGCATGGGGCTGGGAGGAGGTAAGAGCCCTTTGGGCCAAGCCACACTGGAGGAGGTGGAGCAGTGAGGCACCATCCCCCCAAGCTGCCGGTGCAGGACGTGCCTTAAGTACAACTGTGCTCTGGCTTTAAACTCTTC...
GCAGTAATCAATAGTGAGATCCTGGGACACAGGCTGGTTGCAGGAAAGGCCTGGCCTAATTAAACATGCTGCGAAAATTCTTGTAAGAGGGCCTATCACAGCATATGGCCATATATAACCATCGTGTACAGAAGAGGCACTGCCCTGGGGATAGGATGGCAGTTACATGCACACACATGAATGGGCATGGGGCTGGGAGGAGGTAAGAGCCCTTTGGGCCAAGCCACACTGGAGGAGGTGGAGCAGTGAGGCACCATCCCCCCAAGCTGCCGGTGCAGGACGTGCCTTAAGTACAACTGTGCTCTGGCTTTAAACTCTTC...
pathogenic
18,606
Benign or pathogenic: chromosome 1, position 183231027, gene LAMC2 (laminin subunit gamma 2) variant? Disease(s) if pathogenic?
pathogenic; ['Epidermolysis_bullosa,_junctional_3A,_intermediate', 'Epidermolysis_bullosa,_junctional_3B,_severe', 'Junctional_epidermolysis_bullosa', 'Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
CTTGAGAGTAAGCCTAAGCAAACTCAAGTGGGAAGGGGAGTGGGCTGTAAAATAGTTTAAGAGACTCTCTCAGGAAGTCAGCGTAATTGATGTGTAGAAAGGTAACAGTCAACAGTTCTCCTAACAAGACAGCTTCAAAGCAGCAGCTATAGTGGAGCATTCCTGAGGCCTGCTGCAGATCAAAGCATGAATGTGCAGACTGGTCCTCTTGCCCAGCGTTTCTTTCAAATCTTTGCACATGTTATATTTTAGAGGCAAGTTCAGTTCTAGAGGAGCTGGCCTGCCCCACAGACTCACCCCTCAGTCCCAGGCTGACCTTG...
CTTGAGAGTAAGCCTAAGCAAACTCAAGTGGGAAGGGGAGTGGGCTGTAAAATAGTTTAAGAGACTCTCTCAGGAAGTCAGCGTAATTGATGTGTAGAAAGGTAACAGTCAACAGTTCTCCTAACAAGACAGCTTCAAAGCAGCAGCTATAGTGGAGCATTCCTGAGGCCTGCTGCAGATCAAAGCATGAATGTGCAGACTGGTCCTCTTGCCCAGCGTTTCTTTCAAATCTTTGCACATGTTATATTTTAGAGGCAAGTTCAGTTCTAGAGGAGCTGGCCTGCCCCACAGACTCACCCCTCAGTCCCAGGCTGACCTTG...
pathogenic
18,632
Is the chromosome 1, position 183232330 variant in LAMC2 (laminin subunit gamma 2) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Epidermolysis_bullosa,_junctional_3A,_intermediate', 'Epidermolysis_bullosa,_junctional_3B,_severe', 'Junctional_epidermolysis_bullosa', 'Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
GATACACAAATATGTATGCAAATAATGATAACACACTTAGATACGTAATCAGCGTTTTGTGAGCACTGAAGATAGAACAACTCAGAGAATCACTGTAATCATCAGAGAAGTGTCTCACCCACTATCATATCCTTAACTCCTATAACAGAACCTGGCTTAATCAATTTGGTTGAATGAGTAAAGGTATTGCTTTCTTAACTGTATTTCCTACACCAAAGGCCGCAGAACAGAGGAAAGAACATTGGCTCTGCCTGACCTCTCATTGTAGCTTGCCATTTACTTGCCATGTAACCTCAGGCAAATTAGTCAACTTCCCTGAG...
GATACACAAATATGTATGCAAATAATGATAACACACTTAGATACGTAATCAGCGTTTTGTGAGCACTGAAGATAGAACAACTCAGAGAATCACTGTAATCATCAGAGAAGTGTCTCACCCACTATCATATCCTTAACTCCTATAACAGAACCTGGCTTAATCAATTTGGTTGAATGAGTAAAGGTATTGCTTTCTTAACTGTATTTCCTACACCAAAGGCCGCAGAACAGAGGAAAGAACATTGGCTCTGCCTGACCTCTCATTGTAGCTTGCCATTTACTTGCCATGTAACCTCAGGCAAATTAGTCAACTTCCCTGAG...
pathogenic
18,634
Evaluate the clinical significance of the mutation at chromosome 1, position 183235621 in gene LAMC2 (laminin subunit gamma 2): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
GTGTATTGATTGTTTCCTTTATTACAGAAATGTTTGTTGTAGAAAATAAATAAAAATTCTCTATGATCCCATTACTATCAAATAACCACTGTTAAAATTTGGAATATATTCTACTGGACTTTAAATTCATATAAAAAATGTACATGTATATATTTTTATTTTTATTTTTTTTGGCTTCCAGCAGGAAAAGAATTTTTATTTTACTTTGTTGTTGTTTTGGATTTTTTTATGTATATATATTTTAATGCATCTATATCTATATACAGACTTTTTTGAACTTGGATTTCTTTGCTCTTGTCTATACATACTTTTTTTTTCTT...
GTGTATTGATTGTTTCCTTTATTACAGAAATGTTTGTTGTAGAAAATAAATAAAAATTCTCTATGATCCCATTACTATCAAATAACCACTGTTAAAATTTGGAATATATTCTACTGGACTTTAAATTCATATAAAAAATGTACATGTATATATTTTTATTTTTATTTTTTTTGGCTTCCAGCAGGAAAAGAATTTTTATTTTACTTTGTTGTTGTTTTGGATTTTTTTATGTATATATATTTTAATGCATCTATATCTATATACAGACTTTTTTGAACTTGGATTTCTTTGCTCTTGTCTATACATACTTTTTTTTTCTT...
pathogenic
18,642
A genetic variant on chromosome 1, position 183236490, affects the gene LAMC2 (laminin subunit gamma 2). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Junctional_epidermolysis_bullosa']
GAAAGGTGAGCAGCATTAGAGGGCACCTCTGCTTCAAGCCGTCTCTGCAAGGCCAGACTTGAATAAGAGTGTAGGGTATTAGGGACCCAAGCATCGTATTTATTCTCTCCAGGCTCCTTTGCAGCCATTCCCTACCTTGAAACCAGTTTTTAACCACTTGGCTTTTATTGTATGTAAGTGGCCACTGGGCAGGGTCATTTGGCAGGAGTTGGGGGTGAGGGTGTTTCTTTCCCACATTTCCCTATGACTCACAGTATGGCTGTGTTGTATGTCAGATGTGATTCCTCGGGCCACGTGAAATGAATCAGCCCTTGGAAGAG...
GAAAGGTGAGCAGCATTAGAGGGCACCTCTGCTTCAAGCCGTCTCTGCAAGGCCAGACTTGAATAAGAGTGTAGGGTATTAGGGACCCAAGCATCGTATTTATTCTCTCCAGGCTCCTTTGCAGCCATTCCCTACCTTGAAACCAGTTTTTAACCACTTGGCTTTTATTGTATGTAAGTGGCCACTGGGCAGGGTCATTTGGCAGGAGTTGGGGGTGAGGGTGTTTCTTTCCCACATTTCCCTATGACTCACAGTATGGCTGTGTTGTATGTCAGATGTGATTCCTCGGGCCACGTGAAATGAATCAGCCCTTGGAAGAG...
pathogenic
18,646
Variant at chromosome position 183240398, chromosome 1, gene LAMC2 (laminin subunit gamma 2): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
GAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGGTTAGTACTTCATGGTTCAGGTCACTTGAGTATTTTAAGTGTATAGTCATGACCAATTTCCTTTGAATTCTCATATGTCTCTCTAAGTGGCAGGTATATTGGGATATTAATAGATCCTTAGTAAATATCTTTCTAAAGAAAATCTTAATGCATTAATATTTAATGTAGTAGTAATAATAGAGCTAGATGTCAGAAGCCTTGAGTTCTGATCTCTGCTGGGCCACCTAACCAGGCCAGACTAGCTGTGT...
GAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGGTTAGTACTTCATGGTTCAGGTCACTTGAGTATTTTAAGTGTATAGTCATGACCAATTTCCTTTGAATTCTCATATGTCTCTCTAAGTGGCAGGTATATTGGGATATTAATAGATCCTTAGTAAATATCTTTCTAAAGAAAATCTTAATGCATTAATATTTAATGTAGTAGTAATAATAGAGCTAGATGTCAGAAGCCTTGAGTTCTGATCTCTGCTGGGCCACCTAACCAGGCCAGACTAGCTGTGT...
benign
18,661
The chromosome 1, position 183243171 genetic variant in gene LAMC2 (laminin subunit gamma 2): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Junctional_epidermolysis_bullosa_gravis_of_Herlitz']
CTGTAATTCCAGCTACTCAGGAGTCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCCAAGATTGCACCACTGCTCTCCAGCCTGGGGAACAGAGCAAGACTGTCTCAAAAAAAAAAAAAAAAGGAAAAATAAAAAAGAATCACTTGCCGATTTTACATTTGTTCCTCCCCAAACCAAAGTTATACCTTGATGTAACCAGTGGGAGGAACTTGAGCTGCTTGGGTAAATAACCCAGAAGAAATGTGATGAGAGTAGGCCTGTGAGATAATTTTAGGAAGATCTGATGGCACAGCGTGGAAGAAA...
CTGTAATTCCAGCTACTCAGGAGTCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCCAAGATTGCACCACTGCTCTCCAGCCTGGGGAACAGAGCAAGACTGTCTCAAAAAAAAAAAAAAAAGGAAAAATAAAAAAGAATCACTTGCCGATTTTACATTTGTTCCTCCCCAAACCAAAGTTATACCTTGATGTAACCAGTGGGAGGAACTTGAGCTGCTTGGGTAAATAACCCAGAAGAAATGTGATGAGAGTAGGCCTGTGAGATAATTTTAGGAAGATCTGATGGCACAGCGTGGAAGAAA...
pathogenic
18,664
A mutation at chromosome position 183563436 on chromosome 1 in gene NCF2 (neutrophil cytosolic factor 2): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Granulomatous_disease,_chronic,_autosomal_recessive,_cytochrome_b-positive,_type_2']
GCTTACCAGCTCTGTGTCCCTAAGCAAGCAGTGTAACTTCTCAGAACCTCAGTTACCTCACCTGAAATTGAGGCTAGAAGAATTCAATGAGATGACATACAATAATAGTAGTTGACATTTATTGAACACTTACTCTGTGGCAGTACTCTTCTAAATATGTATAAATATTTAGACTTGGTTAATGGTAAGTGTTCCTGCATAGAGTAGATGCTTAATAAATGTTAGTTCATTTTATTTTTCTTTCTTTTCTTTTCTTTTTTTTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCT...
GCTTACCAGCTCTGTGTCCCTAAGCAAGCAGTGTAACTTCTCAGAACCTCAGTTACCTCACCTGAAATTGAGGCTAGAAGAATTCAATGAGATGACATACAATAATAGTAGTTGACATTTATTGAACACTTACTCTGTGGCAGTACTCTTCTAAATATGTATAAATATTTAGACTTGGTTAATGGTAAGTGTTCCTGCATAGAGTAGATGCTTAATAAATGTTAGTTCATTTTATTTTTCTTTCTTTTCTTTTCTTTTTTTTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCT...
pathogenic
18,686
Does the genetic variant at chromosome 1, position 183567222, impacting gene NCF2 (neutrophil cytosolic factor 2), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Granulomatous_disease,_chronic,_autosomal_recessive,_cytochrome_b-positive,_type_2']
TTATCCAGAATCTGCTTCAAGTGCACTTCCCAAGACAGCCCTCTCCACACTAGGAAACAGCCTTTCAGAGAGAACATTTCCATTTCACATCTGCCCATTGGTTCTTTGTTCATCCTCAGGGCTCCACAGAGCAATTTCTTTTCCAGATACAGTGCCTCAGACATTTGAAAACAGCCACTCCATGCCCCTCAGAGATAAGCAGGTATAGTTACTTCAACTTTTCTTCCTGAGACATCGTTTCCCTACCTAATGATCAAGGGGTTTGGTGACTACGTGAGTCACTCAGGAACCAGCTGCATTCACCCAAGCCCCGTGAGTGT...
TTATCCAGAATCTGCTTCAAGTGCACTTCCCAAGACAGCCCTCTCCACACTAGGAAACAGCCTTTCAGAGAGAACATTTCCATTTCACATCTGCCCATTGGTTCTTTGTTCATCCTCAGGGCTCCACAGAGCAATTTCTTTTCCAGATACAGTGCCTCAGACATTTGAAAACAGCCACTCCATGCCCCTCAGAGATAAGCAGGTATAGTTACTTCAACTTTTCTTCCTGAGACATCGTTTCCCTACCTAATGATCAAGGGGTTTGGTGACTACGTGAGTCACTCAGGAACCAGCTGCATTCACCCAAGCCCCGTGAGTGT...
pathogenic
18,698
Clinical significance of chromosome 1, position 183574570, gene NCF2 (neutrophil cytosolic factor 2): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Chronic_granulomatous_disease', 'Granulomatous_disease,_chronic,_autosomal_recessive,_cytochrome_b-positive,_type_2']
TAAACATAGGGCTGTGGAAGTGGGGAAAGACTCCTCAGCCCACTAAAACGTGAACTACAAGGAGCATTAATCCAAGAGGATCCCATGCTGATCTCTTTCCCTAACATGTTCTCTTCATATTTATTTTTATTTTTTAGAAACAGAGTCTCAATCTGTTGCCCAAGCTAGAGTACAGTGGTGCAATCATAGCTCACTGTAGCCTTGAACTCCTGGGCTCAAGTGATCCTCTCACCTCAGCCTCTCCACTAGCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCTCCCACTTCAGCCTTCCAAAGCACTGGGATTACAG...
TAAACATAGGGCTGTGGAAGTGGGGAAAGACTCCTCAGCCCACTAAAACGTGAACTACAAGGAGCATTAATCCAAGAGGATCCCATGCTGATCTCTTTCCCTAACATGTTCTCTTCATATTTATTTTTATTTTTTAGAAACAGAGTCTCAATCTGTTGCCCAAGCTAGAGTACAGTGGTGCAATCATAGCTCACTGTAGCCTTGAACTCCTGGGCTCAAGTGATCCTCTCACCTCAGCCTCTCCACTAGCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCTCCCACTTCAGCCTTCCAAAGCACTGGGATTACAG...
pathogenic
18,707
Gene NCF2 (neutrophil cytosolic factor 2) variant at chromosome position 183590266 on chromosome 1: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Granulomatous_disease,_chronic,_autosomal_recessive,_cytochrome_b-positive,_type_2']
ACACAACAGAGCACCTTGTCCAGGAGAGTAGTAATTACTATTTATTGCTCTGTGGAAGATAAAAAAGATAGGGAAATAGGAGAAGCTTCTTTGAAAAATGAAACATCATTAGACGGGCTTGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAGAAAGAAAAAATGATATCTAATGTAATAATGAAATTTTAACCCTTGTT...
ACACAACAGAGCACCTTGTCCAGGAGAGTAGTAATTACTATTTATTGCTCTGTGGAAGATAAAAAAGATAGGGAAATAGGAGAAGCTTCTTTGAAAAATGAAACATCATTAGACGGGCTTGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAGAAAGAAAAAATGATATCTAATGTAATAATGAAATTTTAACCCTTGTT...
pathogenic
18,718
A genetic alteration at chromosome 1, position 183590577, in gene NCF2—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
ACCCTTGTTGCATTTCTTGTATTCCTATGAATGTATTGAACATTCAGTTTAAATAAATAATAAAATTTATTGCAAATGAAAATAATTAAAATATTATATAAATTGTTATATTTGTTTACTATACAAACTTATACATGAATAGTATACAATTAAAATGATAATGAATAAGAATGCATATAAATGCTAGTAGGAAGGGCTCAAGCAGGAAAACAAAGAAAGGCAGAAGGAATGAGAAGGCTAGAAGCAGAGGAATGCCAGGAGAAACAGAGACATGTGGGCCTGAAGGCCTGGGAGCTGAGAAGTGAGTGGTGGCCCACACA...
ACCCTTGTTGCATTTCTTGTATTCCTATGAATGTATTGAACATTCAGTTTAAATAAATAATAAAATTTATTGCAAATGAAAATAATTAAAATATTATATAAATTGTTATATTTGTTTACTATACAAACTTATACATGAATAGTATACAATTAAAATGATAATGAATAAGAATGCATATAAATGCTAGTAGGAAGGGCTCAAGCAGGAAAACAAAGAAAGGCAGAAGGAATGAGAAGGCTAGAAGCAGAGGAATGCCAGGAGAAACAGAGACATGTGGGCCTGAAGGCCTGGGAGCTGAGAAGTGAGTGGTGGCCCACACA...
benign
18,721
Variant in HMCN1 (hemicentin 1), chromosome 1, position 186015942—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
TCTTCCATAGAGAAGAATTATAAATAAATTATGTAGGTAGTCCCCACTCATAGAAGTAGAACATAATTCCTTACTCCATTTCTATGGGCTGGAATAAGGACTGCCTTCAAAGGAAAGGGGAAGAAAAAGAGTAACTTTACAGTGGAGAAATATGGCAAACACTACCTTAGCCGGGTTACCAAAGGTACATGCTGTCAGCATAACTTAGCACAGGTCTCAGTGATAAGTCATGTTGATAGCATGTACGTTTGGTAGCATGTGATGAAAATAGCACTTTACCTGTATGGGCTGCCTCTCAAAATCCATAATCCTAGCTTAAC...
TCTTCCATAGAGAAGAATTATAAATAAATTATGTAGGTAGTCCCCACTCATAGAAGTAGAACATAATTCCTTACTCCATTTCTATGGGCTGGAATAAGGACTGCCTTCAAAGGAAAGGGGAAGAAAAAGAGTAACTTTACAGTGGAGAAATATGGCAAACACTACCTTAGCCGGGTTACCAAAGGTACATGCTGTCAGCATAACTTAGCACAGGTCTCAGTGATAAGTCATGTTGATAGCATGTACGTTTGGTAGCATGTGATGAAAATAGCACTTTACCTGTATGGGCTGCCTCTCAAAATCCATAATCCTAGCTTAAC...
benign
18,775
Chromosome 1, position 186038044, gene HMCN1 (hemicentin 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
GCTTTTTAACAATTTTTGCTTTGTTATTCAATGCATAAGGTATTGTCATTATAAAATATTATTCATGAATATAAATCATGTTGTTTTGTCATGTTTAATAATTTTTGCTTTGTATAGTTGTCAGAAATCGATGTCAAATTATTGTATATCTTTGTCCTTCTCCTTATTGTAACATTTTTGTGGGTTTTTATTTGTGCTCCTTATCCACTTAGATATTTTAATTAAAAATAGTTTTAACCCATTGTATTAGTCCATGTTCATGCTGCCGATAAAGACATACCCAAGACTGGGCAATTTAGAAAAGAAAGAGGTTTAATGGA...
GCTTTTTAACAATTTTTGCTTTGTTATTCAATGCATAAGGTATTGTCATTATAAAATATTATTCATGAATATAAATCATGTTGTTTTGTCATGTTTAATAATTTTTGCTTTGTATAGTTGTCAGAAATCGATGTCAAATTATTGTATATCTTTGTCCTTCTCCTTATTGTAACATTTTTGTGGGTTTTTATTTGTGCTCCTTATCCACTTAGATATTTTAATTAAAAATAGTTTTAACCCATTGTATTAGTCCATGTTCATGCTGCCGATAAAGACATACCCAAGACTGGGCAATTTAGAAAAGAAAGAGGTTTAATGGA...
benign
18,782
Is the chromosome 1, position 186144718 variant in HMCN1 (hemicentin 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
CACTTGAACTCTACAACATTTTGTATCTTGAAGTCCAATTCTAGTTAGGATTTTCCATATTGATTAAAAAATAAAAATAAAAAAGTCTTTAGCTGAAAACCTGTATTTATATGTAGTAGAAATGACACAGAAATGAATAAATGTTACCCAATTGTTAACCCTCCAATTAAAAATGCATCTATATTAAATGGCATTATATTGTAAGAGGCTGAGGCTTTTGTTAACCAACAGCCTTGAAAATAAAATGTATTAAAATAATTGGAACTTCAGAATTTTTGAAATCATACAGTCAATATTTGAGGGCTATGAGCATCCACAGC...
CACTTGAACTCTACAACATTTTGTATCTTGAAGTCCAATTCTAGTTAGGATTTTCCATATTGATTAAAAAATAAAAATAAAAAAGTCTTTAGCTGAAAACCTGTATTTATATGTAGTAGAAATGACACAGAAATGAATAAATGTTACCCAATTGTTAACCCTCCAATTAAAAATGCATCTATATTAAATGGCATTATATTGTAAGAGGCTGAGGCTTTTGTTAACCAACAGCCTTGAAAATAAAATGTATTAAAATAATTGGAACTTCAGAATTTTTGAAATCATACAGTCAATATTTGAGGGCTATGAGCATCCACAGC...
benign
18,860
Gene mutation in HMCN1 at chromosome 1, position 186152863—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
ATTAAAATGGTTAACACATACTAGATGTTTACCATCATGCATGACATGCTCAATAAACTCTCATTGTCATCACCACCACCAACATATTCTTTATTTTTAGTTTGGGGACTGGACACTGATTGTATTCTTTGGCTTATGAAATATTAATAACACTATGATGTGCACAGATTAGAAGGATCTTAGATTTATGGGTGATGATGGTTGTTATGTGAAAGTAGAATGTTTTAAAAGCTTATTTATTTCACTATTAAATTCAGATGTCATATGACCTTTTTGATGTTTGAGAAAAGATTTGTAGCATCTCTGAATACTGGCCCTCT...
ATTAAAATGGTTAACACATACTAGATGTTTACCATCATGCATGACATGCTCAATAAACTCTCATTGTCATCACCACCACCAACATATTCTTTATTTTTAGTTTGGGGACTGGACACTGATTGTATTCTTTGGCTTATGAAATATTAATAACACTATGATGTGCACAGATTAGAAGGATCTTAGATTTATGGGTGATGATGGTTGTTATGTGAAAGTAGAATGTTTTAAAAGCTTATTTATTTCACTATTAAATTCAGATGTCATATGACCTTTTTGATGTTTGAGAAAAGATTTGTAGCATCTCTGAATACTGGCCCTCT...
benign
18,866
Evaluate if the mutation on chromosome 1 at position 186307034 in PRG4 (proteoglycan 4) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Camptodactyly-arthropathy-coxa_vara-pericarditis_syndrome']
AGTAATGCGTGTTGGCAGAATGAGGACATCTTAATATGGGGGGGAATATAACTTTATGAATATTATCTTAGAAAGTACCAAATGAATACTTCCTACAGGAAATTAGTGCCAAGCGGCTAAGAAGCCACTCTAAAAGCAAAGGATAAGAAGATGCTGTAGCAGGACTGTGGAACCACAAGATGGCACCAGAGATGATTATTGATGGCTTTCTACTGTCATTCTTGTTTACTTGACATCATTTTGCTTCTTCTCCTTCATCTTCCTTGCATTTTCATTTTCCCTTCCCCAGCTTTATTTTAACAAACATTTATATACTATTG...
AGTAATGCGTGTTGGCAGAATGAGGACATCTTAATATGGGGGGGAATATAACTTTATGAATATTATCTTAGAAAGTACCAAATGAATACTTCCTACAGGAAATTAGTGCCAAGCGGCTAAGAAGCCACTCTAAAAGCAAAGGATAAGAAGATGCTGTAGCAGGACTGTGGAACCACAAGATGGCACCAGAGATGATTATTGATGGCTTTCTACTGTCATTCTTGTTTACTTGACATCATTTTGCTTCTTCTCCTTCATCTTCCTTGCATTTTCATTTTCCCTTCCCCAGCTTTATTTTAACAAACATTTATATACTATTG...
pathogenic
18,891
Evaluate the clinical significance of the mutation at chromosome 1, position 186307653 in gene PRG4 (proteoglycan 4): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Camptodactyly-arthropathy-coxa_vara-pericarditis_syndrome']
CGAAGCATTCGCTCTAAATAAATAGCCAGGCATTTAATCTTTTAGTCACCCAGAAAATCGTGCAGGAAGCCACCCTTGGGCTTTGTAGTCCACATGTGGGGCAGCTGCTATGGGAAAGCCTTGATAAATACTGTCTTTTTGCTGCCCATCACACCCTAAGCTCCTCCTTATGTCCCCTGGGACCTGCAAGGTTAGCTGCGCAGAAGAAAAGGAGTGGCTAATAGCCCTATGTATGGGAACAAGGCTCAGCAGGGACTGTGGGGGTGACTGGGGCAGATTGCTCAGAGGTAGCTGTAGAGGCCTCTGAGATAATTGGTGCA...
CGAAGCATTCGCTCTAAATAAATAGCCAGGCATTTAATCTTTTAGTCACCCAGAAAATCGTGCAGGAAGCCACCCTTGGGCTTTGTAGTCCACATGTGGGGCAGCTGCTATGGGAAAGCCTTGATAAATACTGTCTTTTTGCTGCCCATCACACCCTAAGCTCCTCCTTATGTCCCCTGGGACCTGCAAGGTTAGCTGCGCAGAAGAAAAGGAGTGGCTAATAGCCCTATGTATGGGAACAAGGCTCAGCAGGGACTGTGGGGGTGACTGGGGCAGATTGCTCAGAGGTAGCTGTAGAGGCCTCTGAGATAATTGGTGCA...
pathogenic
18,893
A mutation at chromosome position 186308958 on chromosome 1 in gene PRG4 (proteoglycan 4): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Camptodactyly-arthropathy-coxa_vara-pericarditis_syndrome']
ACCCACCACCACCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCACCAAGGAGCCTGCACCCACCACCACCAAGTCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCCCCAAGAAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTACACCCACCACTCCCAAGGAGCCTGCACCCACCACCAAGGAGCCTGCACCCACCACTCCCAAAGAGCCTGCACCCACTGCCCCCAAGAAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACCACTCCCA...
ACCCACCACCACCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCACCAAGGAGCCTGCACCCACCACCACCAAGTCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCCCCAAGAAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTACACCCACCACTCCCAAGGAGCCTGCACCCACCACCAAGGAGCCTGCACCCACCACTCCCAAAGAGCCTGCACCCACTGCCCCCAAGAAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACCACTCCCA...
pathogenic
18,898
Gene mutation in PRG4 (proteoglycan 4) at chromosome 1, position 186309828—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Camptodactyly-arthropathy-coxa_vara-pericarditis_syndrome']
GCCTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGACTGCTCCAACTACCCCTAAAGGGACTGCTCCAACTACCCTCAAGGAACCTGCACCCACTACTCCCAAGAAGCCTGCCCCCAAGGAGCTTGCACCCACCACCACCAAGGAGCCCACATCCACCACCTCTGACAAGCCCGCTCCAACTACCCCTAAGGGGACTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGGGACTGCTCCAACTACCCTCAAGGAACCTGCACCCACTACTC...
GCCTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGACTGCTCCAACTACCCCTAAAGGGACTGCTCCAACTACCCTCAAGGAACCTGCACCCACTACTCCCAAGAAGCCTGCCCCCAAGGAGCTTGCACCCACCACCACCAAGGAGCCCACATCCACCACCTCTGACAAGCCCGCTCCAACTACCCCTAAGGGGACTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGGGACTGCTCCAACTACCCTCAAGGAACCTGCACCCACTACTC...
pathogenic
18,899
Is the genetic mutation found on chromosome 1 at position 186311558, within the gene PRG4 (proteoglycan 4), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Camptodactyly-arthropathy-coxa_vara-pericarditis_syndrome']
ATTGAGTTCATACATCCAAAAAATGTCTAGTTTACATGAAAATCAAGGTAACCTGGTCCATTCCAATTCATAATAATTTATTTCATATAATACTTTTGAAGAGTATCATCTTTAAGTAAAATGGAATTATCAAGTATATAACTATGCAAACAGGTCAAACTGTGTCCTTCAAGATCTTAGAAAAGGTAAACAGGAAATAGAACCATGTGGAAAGACTTGAAAAGAACATACAGACTTTTCTCATTCTGTTCTATATTTGTTTTGTTTTTGTTAATTTGTTTAGATGAGACCAATATATGCAATGGTAAGCCAGTAGATGG...
ATTGAGTTCATACATCCAAAAAATGTCTAGTTTACATGAAAATCAAGGTAACCTGGTCCATTCCAATTCATAATAATTTATTTCATATAATACTTTTGAAGAGTATCATCTTTAAGTAAAATGGAATTATCAAGTATATAACTATGCAAACAGGTCAAACTGTGTCCTTCAAGATCTTAGAAAAGGTAAACAGGAAATAGAACCATGTGGAAAGACTTGAAAAGAACATACAGACTTTTCTCATTCTGTTCTATATTTGTTTTGTTTTTGTTAATTTGTTTAGATGAGACCAATATATGCAATGGTAAGCCAGTAGATGG...
pathogenic
18,901
Assess the variant on chromosome 1, position 193122189, impacting CDC73 (cell division cycle 73): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
benign
TATTGGTAGGGCAATTATAAGGGTACTTAGATAAAAACAAAAATGATCTACAATTGCTTCTGTAGACACAGGGTCTAGGTATGTTGCCCAGGCTGGTCAGGAAAAAAATGATCTACAAATTTCAATGCTTTAACTGTTAAAAGCAACAACTTACTAATGACTTATCTTACCACTTTTTAAAATTCATTAACCTAAAAAACATAATTTCTCTGAAAAGAGAGACTTTAATCATTATTTGAGTATGAAATAAAATTAAGTATCGTTTGAAGGGACTATAGTCGAGCCTCCTAATCATGAAATCTTGGCTTCCTTGAGCTTAT...
TATTGGTAGGGCAATTATAAGGGTACTTAGATAAAAACAAAAATGATCTACAATTGCTTCTGTAGACACAGGGTCTAGGTATGTTGCCCAGGCTGGTCAGGAAAAAAATGATCTACAAATTTCAATGCTTTAACTGTTAAAAGCAACAACTTACTAATGACTTATCTTACCACTTTTTAAAATTCATTAACCTAAAAAACATAATTTCTCTGAAAAGAGAGACTTTAATCATTATTTGAGTATGAAATAAAATTAAGTATCGTTTGAAGGGACTATAGTCGAGCCTCCTAATCATGAAATCTTGGCTTCCTTGAGCTTAT...
benign
18,928
Variant in gene CDC73 (cell division cycle 73), located at chromosome 1 position 193125238: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
TCGATGAAAAACTAGGGAAATTTAGTTTGTTGGTTGGTATTTATTTATTTATTTTTGAGAGGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAATCTTTGCCTCCTGGGTTCAAGTGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGAGGTTGCAGGCCCCCGCCACCATGGCCGGCTAATTTATGTAGTTTAGTAGAGATGTGGTTTCACCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAATAATCTGCCCGCCTCCACTTCCCAAAGTGCTTGGATTACAGGCGTG...
TCGATGAAAAACTAGGGAAATTTAGTTTGTTGGTTGGTATTTATTTATTTATTTTTGAGAGGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAATCTTTGCCTCCTGGGTTCAAGTGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGAGGTTGCAGGCCCCCGCCACCATGGCCGGCTAATTTATGTAGTTTAGTAGAGATGTGGTTTCACCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAATAATCTGCCCGCCTCCACTTCCCAAAGTGCTTGGATTACAGGCGTG...
benign
18,975
Assess the variant on chromosome 1, position 193138138, impacting CDC73 (cell division cycle 73): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Parathyroid_carcinoma']
AATTCTTTCTTTATGAAAGGCCAGATAGTAAATATTTTAGGCCTTATGGGCCATACAGTTTATGTTGCAACTATTTTACTTTAATATTGTAGTGTGAAAGCACTCATAGACAATACATAAATGAACAGATGTGGCTATGTTTCTATAAAAAACTTCAGAAAACAGATGGCGGGCCAGAATTGGTCTTTGGGATGTAGTTTGCCTACCTTTGGAACAATGTGTTATGGGTGCTTGCTTTACTGCTCAGAGCTGTGAACATGAAGTACTTACTACTTTAATGTAATCTTAATTAAGGATATTCTGAGAAATGGATCTGATAT...
AATTCTTTCTTTATGAAAGGCCAGATAGTAAATATTTTAGGCCTTATGGGCCATACAGTTTATGTTGCAACTATTTTACTTTAATATTGTAGTGTGAAAGCACTCATAGACAATACATAAATGAACAGATGTGGCTATGTTTCTATAAAAAACTTCAGAAAACAGATGGCGGGCCAGAATTGGTCTTTGGGATGTAGTTTGCCTACCTTTGGAACAATGTGTTATGGGTGCTTGCTTTACTGCTCAGAGCTGTGAACATGAAGTACTTACTACTTTAATGTAATCTTAATTAAGGATATTCTGAGAAATGGATCTGATAT...
pathogenic
19,019
Mutation found at chromosome 1 position 193138169, gene CDC73 (cell division cycle 73): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Hereditary_cancer-predisposing_syndrome', 'Parathyroid_carcinoma']
ATATTTTAGGCCTTATGGGCCATACAGTTTATGTTGCAACTATTTTACTTTAATATTGTAGTGTGAAAGCACTCATAGACAATACATAAATGAACAGATGTGGCTATGTTTCTATAAAAAACTTCAGAAAACAGATGGCGGGCCAGAATTGGTCTTTGGGATGTAGTTTGCCTACCTTTGGAACAATGTGTTATGGGTGCTTGCTTTACTGCTCAGAGCTGTGAACATGAAGTACTTACTACTTTAATGTAATCTTAATTAAGGATATTCTGAGAAATGGATCTGATATTTTTAAGAGATAATGATGATAATTGATTCAT...
ATATTTTAGGCCTTATGGGCCATACAGTTTATGTTGCAACTATTTTACTTTAATATTGTAGTGTGAAAGCACTCATAGACAATACATAAATGAACAGATGTGGCTATGTTTCTATAAAAAACTTCAGAAAACAGATGGCGGGCCAGAATTGGTCTTTGGGATGTAGTTTGCCTACCTTTGGAACAATGTGTTATGGGTGCTTGCTTTACTGCTCAGAGCTGTGAACATGAAGTACTTACTACTTTAATGTAATCTTAATTAAGGATATTCTGAGAAATGGATCTGATATTTTTAAGAGATAATGATGATAATTGATTCAT...
pathogenic
19,026
The genetic variant at chromosome 1, position 193141961, affecting gene CDC73 (cell division cycle 73): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Hyperparathyroidism_1', 'Parathyroid_carcinoma']
CTGTCTAATTCACTTGGGTGGTTCTTTATTCAACCTTACATAGTTTCTTCATATTTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATAT...
CTGTCTAATTCACTTGGGTGGTTCTTTATTCAACCTTACATAGTTTCTTCATATTTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATAT...
pathogenic
19,036
Clinical significance of chromosome 1, position 193142015, gene CDC73 (cell division cycle 73): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['CDC73-related_disorder', 'Hereditary_cancer-predisposing_syndrome', 'Hyperparathyroidism_1', 'Hyperparathyroidism_2_with_jaw_tumors', 'Parathyroid_carcinoma']
TTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTG...
TTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTG...
pathogenic
19,041
The genetic variant at chromosome 1, position 193142015, affecting gene CDC73 (cell division cycle 73): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Hyperparathyroidism_2_with_jaw_tumors', 'Parathyroid_carcinoma']
TTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTG...
TTGTGCTAGTCAGAATTCTGCTGGGGTACGTGAGGGGGATCTTCTGTGCAGTTCTCAGGTCTTCTGACCTATGAATTCTAAACACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTG...
pathogenic
19,043
Is chromosome 1, position 193142098, gene CDC73 (cell division cycle 73) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
ACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTGGAGGGTTAGTCTAGTCTCTGGTACTTCATCTTGGCTGTAAGTAAAAATTCTATGTTTCAAAGTCCATTGGAGGCTTGATTATA...
ACCTTGGTCTTGCTGTAGTCTCAGCTCCATTTCTTCTTATCAGAGAATCCGCTCAGCTCTACATGGGTTCTCCTCCCAAGGCCATGTCTTGGAAACTTACAGGCAATAAGCTGAGGCAGTCATAGGGCTTACCTTGTTTGTTTCTCATTTGTTAGGGAATTACTGTCCTTCATTGCTTGATATCTAGCATCTAGTAAACCATTGTTTTATGTATTTTGACTGGTTATTTAAAGGCTGGAGGGTTAGTCTAGTCTCTGGTACTTCATCTTGGCTGTAAGTAAAAATTCTATGTTTCAAAGTCCATTGGAGGCTTGATTATA...
benign
19,052
Gene CDC73 (cell division cycle 73) variant at chromosome position 193150292 on chromosome 1: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
TGGCCTACTCATTGTTGCTTGGGACAATTGCTAACCATTGTTAATAACATAAATCCCTGTTAACTCCCAGTTTGGGGTTCTTTTTGGCATTGTATCTATTACATCTTGGTGAATGTATTTCTCTTGATCACCAGCCATGCTGTCCTTTAATTGTACCTCCATTTCAGCTGCTCTGAGAGTTGACTGCCTTCTCTTTGAAGTGCCACTTAAGACCCTCCCAAAGTAAATTTCACGTATGACATATAGCCTATATTTAAATTCAAACATCCTCTAATTTTGTTGAAAATCCTTCCAGCTATTTTCATATGATTCAACAAAGG...
TGGCCTACTCATTGTTGCTTGGGACAATTGCTAACCATTGTTAATAACATAAATCCCTGTTAACTCCCAGTTTGGGGTTCTTTTTGGCATTGTATCTATTACATCTTGGTGAATGTATTTCTCTTGATCACCAGCCATGCTGTCCTTTAATTGTACCTCCATTTCAGCTGCTCTGAGAGTTGACTGCCTTCTCTTTGAAGTGCCACTTAAGACCCTCCCAAAGTAAATTTCACGTATGACATATAGCCTATATTTAAATTCAAACATCCTCTAATTTTGTTGAAAATCCTTCCAGCTATTTTCATATGATTCAACAAAGG...
benign
19,072
Classify the chromosome 1 variant at position 193152366 affecting gene CDC73 (cell division cycle 73) as benign or pathogenic. If pathogenic, which disease(s) is associated?
benign
CACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGAAAAGAAGGCAAGTTGCTTAATTCTTATCTTCCCCTTAGTGTGGTTGTGTTGAACTTGAGAGGCAGTGTGGCCTGATGTTTAAGGGTAAGGGTTGGCAAAGTAATGTCTACAGACCAGATCTTACCCACTGCAATTTTTCTTAAATAACATTTTGTTGGGACACAACCACACTCATTCATTTATGTATTTTATATATGGCTGCTTTGGCTTTGTGACATCAGTATTGAATTGTTTCAGTAGAGACTGTGTAGCCTACAAAGCC...
CACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGAAAAGAAGGCAAGTTGCTTAATTCTTATCTTCCCCTTAGTGTGGTTGTGTTGAACTTGAGAGGCAGTGTGGCCTGATGTTTAAGGGTAAGGGTTGGCAAAGTAATGTCTACAGACCAGATCTTACCCACTGCAATTTTTCTTAAATAACATTTTGTTGGGACACAACCACACTCATTCATTTATGTATTTTATATATGGCTGCTTTGGCTTTGTGACATCAGTATTGAATTGTTTCAGTAGAGACTGTGTAGCCTACAAAGCC...
benign
19,082
Mutation at chromosome 1, position 193152366, within CDC73 (cell division cycle 73): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
CACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGAAAAGAAGGCAAGTTGCTTAATTCTTATCTTCCCCTTAGTGTGGTTGTGTTGAACTTGAGAGGCAGTGTGGCCTGATGTTTAAGGGTAAGGGTTGGCAAAGTAATGTCTACAGACCAGATCTTACCCACTGCAATTTTTCTTAAATAACATTTTGTTGGGACACAACCACACTCATTCATTTATGTATTTTATATATGGCTGCTTTGGCTTTGTGACATCAGTATTGAATTGTTTCAGTAGAGACTGTGTAGCCTACAAAGCC...
CACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGAAAAGAAGGCAAGTTGCTTAATTCTTATCTTCCCCTTAGTGTGGTTGTGTTGAACTTGAGAGGCAGTGTGGCCTGATGTTTAAGGGTAAGGGTTGGCAAAGTAATGTCTACAGACCAGATCTTACCCACTGCAATTTTTCTTAAATAACATTTTGTTGGGACACAACCACACTCATTCATTTATGTATTTTATATATGGCTGCTTTGGCTTTGTGACATCAGTATTGAATTGTTTCAGTAGAGACTGTGTAGCCTACAAAGCC...
benign
19,083
Evaluate the clinical significance of the mutation at chromosome 1, position 193212385 in gene CDC73 (cell division cycle 73): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
TTTAAAGATGGTATCCATTTTTAAGAACTGACATTGAATTAGAATTTTAAGTCTCCTAAATTTTTCTTTATTTTTGTCATTTAAAAAACAAAACTCAAGCACAGCTTGTAGCACATTGAGTTATTGTATGGTCAAATACTGAAAATAGAACTTGCAGCACTTTTTATCCTAAGATGTATTCATCTTGTGTTAGGTTATTATTACCATTATGTCAACAAATATTTCTAAGCATTAAAAGTTCATTGTATATAAACAAAATACAAACATATGGGCCAGGCTCAGTGGCTCACCTGTGTAATCCCAGCACTTTGGGAGGCTGA...
TTTAAAGATGGTATCCATTTTTAAGAACTGACATTGAATTAGAATTTTAAGTCTCCTAAATTTTTCTTTATTTTTGTCATTTAAAAAACAAAACTCAAGCACAGCTTGTAGCACATTGAGTTATTGTATGGTCAAATACTGAAAATAGAACTTGCAGCACTTTTTATCCTAAGATGTATTCATCTTGTGTTAGGTTATTATTACCATTATGTCAACAAATATTTCTAAGCATTAAAAGTTCATTGTATATAAACAAAATACAAACATATGGGCCAGGCTCAGTGGCTCACCTGTGTAATCCCAGCACTTTGGGAGGCTGA...
benign
19,108
Variant at chromosome position 193250665, chromosome 1, gene CDC73 (cell division cycle 73): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
TGATTAATAGGAGGAAGTCAAAATATTAACATAACCAGAAGTTTAGAAGAAGTTGATTCCTACCTTCATGGTTCATAGATGACTTTGAGGGGTTCAAGACTTCAGTGGAGGAAATAAAGATAGGGTGTGGAAATAGCAAGTGAACTAGCATTAGAAGTGGAGCTTGAAGATGTGACTGAATTGCTGCACACTCATGCTGGAACTTGAATGGATGAGGAGTTCCTTCTTACAGATGAGCAAAGAAAGTGGTTTTTTTGAGATAGAATTCACTCCAGTGAGCACTTTCGTGAAGATGCCATAAACGTTGTTGAAATGACAAC...
TGATTAATAGGAGGAAGTCAAAATATTAACATAACCAGAAGTTTAGAAGAAGTTGATTCCTACCTTCATGGTTCATAGATGACTTTGAGGGGTTCAAGACTTCAGTGGAGGAAATAAAGATAGGGTGTGGAAATAGCAAGTGAACTAGCATTAGAAGTGGAGCTTGAAGATGTGACTGAATTGCTGCACACTCATGCTGGAACTTGAATGGATGAGGAGTTCCTTCTTACAGATGAGCAAAGAAAGTGGTTTTTTTGAGATAGAATTCACTCCAGTGAGCACTTTCGTGAAGATGCCATAAACGTTGTTGAAATGACAAC...
benign
19,180
A genetic alteration at chromosome 1, position 196492292, in gene KCNT2 (potassium sodium-activated channel subfamily T member 2)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Developmental_and_epileptic_encephalopathy,_57', 'Seizure']
TATGTTTATATGTTTAAGCATTTTATACATCCATAAATTTTGGGATAAACTTTGGCTAGAAAATCTAGCTGCTTACAAATTCACAAGCCAAGTTATAAAACTTATACCTTCACAGAATCTTGTAGATTTGATTATAAAGAAATTAATTATATTTGTATAGTTCTATGTTGTATATTTAATATTAACTATATAATTATAATACATTCCAATTATATAATTATATATATTATTTATTCATTATATAATAATATATATTATATAAGTATAGAGAAATCTTAATAGCATACACTGAGAAACACACACACGATCAATCTCTCCAT...
TATGTTTATATGTTTAAGCATTTTATACATCCATAAATTTTGGGATAAACTTTGGCTAGAAAATCTAGCTGCTTACAAATTCACAAGCCAAGTTATAAAACTTATACCTTCACAGAATCTTGTAGATTTGATTATAAAGAAATTAATTATATTTGTATAGTTCTATGTTGTATATTTAATATTAACTATATAATTATAATACATTCCAATTATATAATTATATATATTATTTATTCATTATATAATAATATATATTATATAAGTATAGAGAAATCTTAATAGCATACACTGAGAAACACACACACGATCAATCTCTCCAT...
pathogenic
19,192
The mutation impacting CFH (complement factor H) on chromosome 1 at position 196673839: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
benign
19,202
Variant chromosome 1, position 196673839, gene CFH (complement factor H): benign or pathogenic? Disease(s)?
benign
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
benign
19,203
Classify the chromosome 1 variant at position 196673839 affecting gene CFH (complement factor H) as benign or pathogenic. If pathogenic, which disease(s) is associated?
benign
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
benign
19,204
Determine whether the variant at chromosome 1, position 196673839, in gene CFH (complement factor H) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
ATGTTTGCTTTTCTGCTGTTTTGACTCTGTTCTTATATATATATAATCTTAAATGCTCATATATAAATGAAACAGCAGAAAAGTGAACATATATATAAGAGCTTTTATTATATATAAATAATATATATATGTATACAGCTTTTCTGCTGTTTTGACATCTGCTCTTAAATATCATCCAGAGTGACTTTCAAATATGGCATGTTTTGATGAGAATACTAGTTGTGTATTTGAGTCAGATCCATTTTCTTATTGAGACTTTTTTTCTATGAGACAACGGGAAAGTCAGTCTTCCCGTATGAAGCTACCTAGACTCTAGCAAA...
benign
19,205
Is the genetic variant on chromosome 1, position 196737474, gene CFH (complement factor H), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Age_related_macular_degeneration_4', 'Basal_laminar_drusen', 'Factor_H_deficiency', 'Hemolytic_uremic_syndrome,_atypical,_susceptibility_to,_1']
GGTCACAATGTTCTTCAAATTTATTTGCCATGTCACAAAATGTTAAATAATCTCTTTCTTAATTGTTTACTATCAGCAAATACTTTAAATTAAATAATAATGATTGTGGTACACATTAAAATCAATGGGATACAGCTGAAACAGAGATGTATTTAGCATTATAACATGCATCAGAAAAAACAAATAAAAAAATAAAAGCAACAGGTACTACAATCTAGAAGGTAGACAGGAATGTACACCCAACAAAAATAGAAGGAAAGAATCATTCAAGCATAAATAGTTGACCATTAATCTTAAGAAAAATAAATTGATGAGAATGT...
GGTCACAATGTTCTTCAAATTTATTTGCCATGTCACAAAATGTTAAATAATCTCTTTCTTAATTGTTTACTATCAGCAAATACTTTAAATTAAATAATAATGATTGTGGTACACATTAAAATCAATGGGATACAGCTGAAACAGAGATGTATTTAGCATTATAACATGCATCAGAAAAAACAAATAAAAAAATAAAAGCAACAGGTACTACAATCTAGAAGGTAGACAGGAATGTACACCCAACAAAAATAGAAGGAAAGAATCATTCAAGCATAAATAGTTGACCATTAATCTTAAGAAAAATAAATTGATGAGAATGT...
pathogenic
19,254
Mutation found at chromosome 1 position 196740606, gene CFH (complement factor H): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GGCAGTCATTAAACCTTAAATTTCCAAGATTATCTCCTTTGACTCCATGTCTCACATTCAGGTCATGCTGATGCAAGAGATGGGCTCCCACAGCCTTGTGCAGATGTGGCTTTGTCCCCCTCCTGGTTGCTTTCATGGGCTGGCATTGAGTGTCTGTGGCTTTTCCAGGAACATAGTGCAAGCTATTGATGGATCTACCATTCTGGGGCTTCAATGATTGTGGTCCTGTTCTCACAGCTCCACAAGGCAGTGCCTCAGTGGGGACTCTATGTGAGGGCTCTGACCCCACATTTCCTTTCCTCAATGGCCTAGCAGAGGTT...
GGCAGTCATTAAACCTTAAATTTCCAAGATTATCTCCTTTGACTCCATGTCTCACATTCAGGTCATGCTGATGCAAGAGATGGGCTCCCACAGCCTTGTGCAGATGTGGCTTTGTCCCCCTCCTGGTTGCTTTCATGGGCTGGCATTGAGTGTCTGTGGCTTTTCCAGGAACATAGTGCAAGCTATTGATGGATCTACCATTCTGGGGCTTCAATGATTGTGGTCCTGTTCTCACAGCTCCACAAGGCAGTGCCTCAGTGGGGACTCTATGTGAGGGCTCTGACCCCACATTTCCTTTCCTCAATGGCCTAGCAGAGGTT...
benign
19,259
Variant at chromosome position 197061935, chromosome 1, gene F13B (coagulation factor XIII B chain): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Coagulation_factor_deficiency_syndrome', 'Factor_XIII,_b_subunit,_deficiency_of']
GGCAGCTTTTACAAGATGACCTCTTTTCCCATTTTCACTTCTGGGCATTATTCTTCTGCTTTTCCTGCTTTCTCTGCTTTCTACCTCACTATTTTGGAGATTAATTTTTACATCTGGAAATATGTGGCAAATTAAGAGAAAATATCCTTGCAAAGCTGCCAGATTGGGGTAATTAGTCCTAATAATTCCCAATAAGAAAAGTTATTCGTTATAATAAGGGATTTAAAATGTATAATAGATATTTTAAAATAATAAATTTAAAAGATATAGTCATTTACAAACTAAGACAAAACAAGATTTATTCAGGTGGGATATATTAA...
GGCAGCTTTTACAAGATGACCTCTTTTCCCATTTTCACTTCTGGGCATTATTCTTCTGCTTTTCCTGCTTTCTCTGCTTTCTACCTCACTATTTTGGAGATTAATTTTTACATCTGGAAATATGTGGCAAATTAAGAGAAAATATCCTTGCAAAGCTGCCAGATTGGGGTAATTAGTCCTAATAATTCCCAATAAGAAAAGTTATTCGTTATAATAAGGGATTTAAAATGTATAATAGATATTTTAAAATAATAAATTTAAAAGATATAGTCATTTACAAACTAAGACAAAACAAGATTTATTCAGGTGGGATATATTAA...
pathogenic
19,414
Variant at chromosome 1, position 197088361, gene ASPM (assembly factor for spindle microtubules): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Microcephaly_5,_primary,_autosomal_recessive']
CACTAATTAAATGCCATGACGGTTCACCAAAATAAATTAAATCTTTTTGCCAATAAAATCAGAAAATGTCAATCTAAATTTCCAGAAGGAGAAATTTCAAGAATCAGGGTGATTATGGGAGGACTGGAGGTTGATATTTTGGCTAAGAAGGACTTTTGGCACTTCTTAAACAGTGTAGTTTGTCTTTCATGCAAAATAAAATAAATAAAATAAAATGACAAAACTTATAACAAGCTTCTTAGCCTTAGCTCTTAACTATTTAATATAAGAAGTTTGTTGAATAACTATTAAATGTCCAAAGCTACAGTATAATGTTATTT...
CACTAATTAAATGCCATGACGGTTCACCAAAATAAATTAAATCTTTTTGCCAATAAAATCAGAAAATGTCAATCTAAATTTCCAGAAGGAGAAATTTCAAGAATCAGGGTGATTATGGGAGGACTGGAGGTTGATATTTTGGCTAAGAAGGACTTTTGGCACTTCTTAAACAGTGTAGTTTGTCTTTCATGCAAAATAAAATAAATAAAATAAAATGACAAAACTTATAACAAGCTTCTTAGCCTTAGCTCTTAACTATTTAATATAAGAAGTTTGTTGAATAACTATTAAATGTCCAAAGCTACAGTATAATGTTATTT...
pathogenic
19,424
The mutation impacting ASPM (assembly factor for spindle microtubules) on chromosome 1 at position 197092013: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic
TGATGACTTCCATACAAGGAATACTGCGATTACAACTTCGGATCAAAACAAATATTTTAGAAATTGCTCCACTCTGGGCCATGTTCTCACAACAAAGTGGAGACAATCTAGTAACTACCTCTGAAAGAAAAAAAAAACACACACACACAGGTAAATTTACAGCAACAAAATGAAGTTTTAGCTAATAATGTAGTATTACATCATTCTTTAAACATGTTAACACAAACTAACCTAGGTGTTTTAAGGCCTCAAGAATGGCAGAAAGGTGCTTATATGTCAAAAGGTAATGAAGTGCAAGTGCAGTTCTTTTGTAGAGTTTG...
TGATGACTTCCATACAAGGAATACTGCGATTACAACTTCGGATCAAAACAAATATTTTAGAAATTGCTCCACTCTGGGCCATGTTCTCACAACAAAGTGGAGACAATCTAGTAACTACCTCTGAAAGAAAAAAAAAACACACACACACAGGTAAATTTACAGCAACAAAATGAAGTTTTAGCTAATAATGTAGTATTACATCATTCTTTAAACATGTTAACACAAACTAACCTAGGTGTTTTAAGGCCTCAAGAATGGCAGAAAGGTGCTTATATGTCAAAAGGTAATGAAGTGCAAGTGCAGTTCTTTTGTAGAGTTTG...
pathogenic
19,446
Clinical significance of chromosome 1, position 197092026, gene ASPM (assembly factor for spindle microtubules): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Inborn_genetic_diseases', 'Lissencephaly', 'Microcephaly', 'Microcephaly_5,_primary,_autosomal_recessive']
ACAAGGAATACTGCGATTACAACTTCGGATCAAAACAAATATTTTAGAAATTGCTCCACTCTGGGCCATGTTCTCACAACAAAGTGGAGACAATCTAGTAACTACCTCTGAAAGAAAAAAAAAACACACACACACAGGTAAATTTACAGCAACAAAATGAAGTTTTAGCTAATAATGTAGTATTACATCATTCTTTAAACATGTTAACACAAACTAACCTAGGTGTTTTAAGGCCTCAAGAATGGCAGAAAGGTGCTTATATGTCAAAAGGTAATGAAGTGCAAGTGCAGTTCTTTTGTAGAGTTTGTTTTCTTCTCGAA...
ACAAGGAATACTGCGATTACAACTTCGGATCAAAACAAATATTTTAGAAATTGCTCCACTCTGGGCCATGTTCTCACAACAAAGTGGAGACAATCTAGTAACTACCTCTGAAAGAAAAAAAAAACACACACACACAGGTAAATTTACAGCAACAAAATGAAGTTTTAGCTAATAATGTAGTATTACATCATTCTTTAAACATGTTAACACAAACTAACCTAGGTGTTTTAAGGCCTCAAGAATGGCAGAAAGGTGCTTATATGTCAAAAGGTAATGAAGTGCAAGTGCAGTTCTTTTGTAGAGTTTGTTTTCTTCTCGAA...
pathogenic
19,447
The mutation impacting ASPM (assembly factor for spindle microtubules) on chromosome 1 at position 197100538: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Microcephaly_5,_primary,_autosomal_recessive']
ATTGTTATTTTGGCTATTTAATCATTTTAAGTGAATAAAACCATAACTAATACATCCAATGAACACCTTTCAATTGTGAACTTCTCAGTAGTGTTAGGAATTTGATACCATAATCTCTTACCTTTCTTCTTTCCCTCTTAACACCTTGGTTTCTTGATACCATTAATCTCTTACCTTTCTTCTTTCCCTCTTAACACCTTGTTGGCTTCTCTTGTCAATGTCTGTGAATTTTGATGTTCTTCAGGGCTCAAGTCCCAGGCCCTCTTTGTTCACTCATTTTATGTATTGTTCCTTGGTGATCTCATTATTCCCAGAACTTT...
ATTGTTATTTTGGCTATTTAATCATTTTAAGTGAATAAAACCATAACTAATACATCCAATGAACACCTTTCAATTGTGAACTTCTCAGTAGTGTTAGGAATTTGATACCATAATCTCTTACCTTTCTTCTTTCCCTCTTAACACCTTGGTTTCTTGATACCATTAATCTCTTACCTTTCTTCTTTCCCTCTTAACACCTTGTTGGCTTCTCTTGTCAATGTCTGTGAATTTTGATGTTCTTCAGGGCTCAAGTCCCAGGCCCTCTTTGTTCACTCATTTTATGTATTGTTCCTTGGTGATCTCATTATTCCCAGAACTTT...
pathogenic
19,460
A mutation at chromosome position 197100743 on chromosome 1 in gene ASPM (assembly factor for spindle microtubules): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['ASPM-related_disorder', 'Microcephaly_5,_primary,_autosomal_recessive']
CTTCTCTTGTCAATGTCTGTGAATTTTGATGTTCTTCAGGGCTCAAGTCCCAGGCCCTCTTTGTTCACTCATTTTATGTATTGTTCCTTGGTGATCTCATTATTCCCAGAACTTTAATTATTAGCATATGCCCATAATGTACAAATCAAATTCTAATACTCACACTACTCTCCTGAACTCCAGACAAACATAGTCAACTGCCTTACTAGATATTTCAAGGGGGTTACCTGCTAGGTACTTCAGATCTTATATACTCCAAACTGAATTCATCATCAATCTCAAAACCTGCTCTTCCCTCTTTATTCCCTATGTCAGGGTGT...
CTTCTCTTGTCAATGTCTGTGAATTTTGATGTTCTTCAGGGCTCAAGTCCCAGGCCCTCTTTGTTCACTCATTTTATGTATTGTTCCTTGGTGATCTCATTATTCCCAGAACTTTAATTATTAGCATATGCCCATAATGTACAAATCAAATTCTAATACTCACACTACTCTCCTGAACTCCAGACAAACATAGTCAACTGCCTTACTAGATATTTCAAGGGGGTTACCTGCTAGGTACTTCAGATCTTATATACTCCAAACTGAATTCATCATCAATCTCAAAACCTGCTCTTCCCTCTTTATTCCCTATGTCAGGGTGT...
pathogenic
19,461
Variant on chromosome 1, at position 197101052, affecting ASPM (assembly factor for spindle microtubules): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Microcephaly_5,_primary,_autosomal_recessive']
TGTCAGGGTGTGAGGGAGTAACTCTGCTGAGTTACTTAAGCCATCAACATGGCTTGCCTCCTTGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTG...
TGTCAGGGTGTGAGGGAGTAACTCTGCTGAGTTACTTAAGCCATCAACATGGCTTGCCTCCTTGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTG...
pathogenic
19,464
Does the variant on chromosome 1 at location 197101058 affecting gene ASPM (assembly factor for spindle microtubules) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Microcephaly_5,_primary,_autosomal_recessive']
GGTGTGAGGGAGTAACTCTGCTGAGTTACTTAAGCCATCAACATGGCTTGCCTCCTTGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTGTCTTAA...
GGTGTGAGGGAGTAACTCTGCTGAGTTACTTAAGCCATCAACATGGCTTGCCTCCTTGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTGTCTTAA...
pathogenic
19,465
Variant chromosome 1, position 197101114, gene ASPM (assembly factor for spindle microtubules): benign or pathogenic? Disease(s)?
pathogenic; ['Inborn_genetic_diseases', 'Microcephaly_5,_primary,_autosomal_recessive']
TGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTGTCTTAAAAATCTATCCACAATCTTACTCCCTCTATTGCCAACCTGGTCCCATATCACTTTTT...
TGTTCATGCTCTATATAATGCCAACTTACAATCCCATTGTCACAAACCTACACTGAACTATAACTCTTTCTCACCTGGCTTACTGCCTATTTTCATTTGGTCTACCTGATTCTAGTCTTGCTCCTTTTCCAGTCCATCTTCCACATTCCTGCCAGAGTAATTTTTTTTTTTTTTTTAATAAAAATGACTGTGGTCTTCTCCTGCTTAAACTCCTCTAGAATTTGTTTTGTCTGGAGCATAAAGACTAAATTTTTTCTGTCTTAAAAATCTATCCACAATCTTACTCCCTCTATTGCCAACCTGGTCCCATATCACTTTTT...
pathogenic
19,468