question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Is chromosome 12, position 51684150, gene SCN8A (sodium voltage-gated channel alpha subunit 8) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
TTTCTCCTTTATTAATATGTTGCATTACATTGGTTGATTTTCAAATGCTAAACTATCTTTGCATTCCTGGGATAAATCCCACTTGGTCATGGTGTGCAACCCTTTTTATATGCTACTGGATTTGGTTTGCTGGCATTTTTGTTGAGGCTGTCTGTGTCTATATTCATAAGGGATGTTAGTATAGAGTTTTCTTATGATGTCTTTGGTTTTGTATCAAGGTAATACTGGCCTTTAGAATGAGTTTAGAAATGTTCTCTTCTATTTTGTGGGAGAGTTTGTTTAATTCTTTAAACATTTGGTAGAATTCATCAGCAAAACCG...
TTTCTCCTTTATTAATATGTTGCATTACATTGGTTGATTTTCAAATGCTAAACTATCTTTGCATTCCTGGGATAAATCCCACTTGGTCATGGTGTGCAACCCTTTTTATATGCTACTGGATTTGGTTTGCTGGCATTTTTGTTGAGGCTGTCTGTGTCTATATTCATAAGGGATGTTAGTATAGAGTTTTCTTATGATGTCTTTGGTTTTGTATCAAGGTAATACTGGCCTTTAGAATGAGTTTAGAAATGTTCTCTTCTATTTTGTGGGAGAGTTTGTTTAATTCTTTAAACATTTGGTAGAATTCATCAGCAAAACCG...
benign
196,970
Variant at chromosome position 51706586, chromosome 12, gene SCN8A (sodium voltage-gated channel alpha subunit 8): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Early_infantile_epileptic_encephalopathy_with_suppression_bursts']
CACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTGGGAGAATTGCTTTAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATGATGGCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCACCTACAAAAAAAAAAAAAAAAAAATGGGTCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGCTCAAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGGCACCTGTAATC...
CACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTGGGAGAATTGCTTTAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATGATGGCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCACCTACAAAAAAAAAAAAAAAAAAATGGGTCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGCTCAAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGGCACCTGTAATC...
pathogenic
197,032
Does the genetic variant at chromosome 12, position 51721527, impacting gene SCN8A (sodium voltage-gated channel alpha subunit 8), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
AAAAGATAAGGGCAGAAATGTTAAAGAGGAGCCCCATGGCCCTTCCAGTGTTAACATCAAAAGTGTTAACAGGCTGGGCGTGGTGCCTCCCTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAACCCAGGAGTTCGAGATCAGCCTGGGCAACATAGAGAAGTAAATTCAGGGGTGAGCAGTAAAATACATTAAAACATAAAAGTGTACATTCAAATAAAATTCCCTAGGGAATATGGAAAGGAAGCATGAAATTGAAGGAGAAGAATAAATAAGAAAAAATTTATGCTAAAGAATTCTTGGCC...
AAAAGATAAGGGCAGAAATGTTAAAGAGGAGCCCCATGGCCCTTCCAGTGTTAACATCAAAAGTGTTAACAGGCTGGGCGTGGTGCCTCCCTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAACCCAGGAGTTCGAGATCAGCCTGGGCAACATAGAGAAGTAAATTCAGGGGTGAGCAGTAAAATACATTAAAACATAAAAGTGTACATTCAAATAAAATTCCCTAGGGAATATGGAAAGGAAGCATGAAATTGAAGGAGAAGAATAAATAAGAAAAAATTTATGCTAAAGAATTCTTGGCC...
benign
197,038
Variant at chromosome position 51721871, chromosome 12, gene SCN8A (sodium voltage-gated channel alpha subunit 8): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Early_infantile_epileptic_encephalopathy_with_suppression_bursts', 'Inborn_genetic_diseases', 'SCN8A-related_disorder']
TCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTAGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGCAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAATTCTTTAAGTAAATTTCTTTACCACAAACTTTACGGTAAACAAG...
TCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTAGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGCAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAATTCTTTAAGTAAATTTCTTTACCACAAACTTTACGGTAAACAAG...
pathogenic
197,053
Is the chromosome 12, position 51745885 variant in SCN8A (sodium voltage-gated channel alpha subunit 8) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
AGATTTCTTAGCACTTTGGGAGTCCAAGGTGGGTGGATCACCTGAGGCCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAACCCATCAAGAGGACAGGGACCATGTTGTATGTGTTGTTCGCCACTGTATCCACACCACTTAGCAAACAATAAGTATTTGTTTAAATAAAATTAAATTTTAGCTGGGCATGGTGGCTCACATCTGTAATCCCAGCGTTTTGGAAGGCTGAGGTGGGAGGATCACTTGAGGCCAGGAGTTCCAGACCAGCCTGGATAACATGGCGAAACCTTGTCTTTACTAAAAAATACAAAAATTA...
AGATTTCTTAGCACTTTGGGAGTCCAAGGTGGGTGGATCACCTGAGGCCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAACCCATCAAGAGGACAGGGACCATGTTGTATGTGTTGTTCGCCACTGTATCCACACCACTTAGCAAACAATAAGTATTTGTTTAAATAAAATTAAATTTTAGCTGGGCATGGTGGCTCACATCTGTAATCCCAGCGTTTTGGAAGGCTGAGGTGGGAGGATCACTTGAGGCCAGGAGTTCCAGACCAGCCTGGATAACATGGCGAAACCTTGTCTTTACTAAAAAATACAAAAATTA...
benign
197,056
Mutation at chromosome 12, position 51751340, within SCN8A (sodium voltage-gated channel alpha subunit 8): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
CCCTGTAGGGCAGGAAAACCCCTTTTTGCTGTGTGGCAAGACTCAAGACCTAGTTCATTTTAAAACATTACAATTGTGTCAACTGTCATAAATGTGAGCAGTCGCAGCTTCAACCTCCACGTGCCAATGAGCAACAGTCGTTTGGAGAAGGGAGGAGATAAAAAAGGGAACGGAACTAAATTTCCAAATATGTACTGTAAGAATTTATGGAAATAAGAGAACCTTGTCATTTTCTTTTTTGGGGGAGAAAACTATATTTACCTTAGGAAGGGAGGGAGTTCTCTGAGGAAGAAGCCACAGCAGATTTTCCTCACAGACTT...
CCCTGTAGGGCAGGAAAACCCCTTTTTGCTGTGTGGCAAGACTCAAGACCTAGTTCATTTTAAAACATTACAATTGTGTCAACTGTCATAAATGTGAGCAGTCGCAGCTTCAACCTCCACGTGCCAATGAGCAACAGTCGTTTGGAGAAGGGAGGAGATAAAAAAGGGAACGGAACTAAATTTCCAAATATGTACTGTAAGAATTTATGGAAATAAGAGAACCTTGTCATTTTCTTTTTTGGGGGAGAAAACTATATTTACCTTAGGAAGGGAGGGAGTTCTCTGAGGAAGAAGCCACAGCAGATTTTCCTCACAGACTT...
benign
197,061
Mutation at chromosome 12, position 51751606, within SCN8A (sodium voltage-gated channel alpha subunit 8): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
GAAGGGAGGGAGTTCTCTGAGGAAGAAGCCACAGCAGATTTTCCTCACAGACTTCCTTTCCCACGCAGCCTCCCACGTGGCGCTTACAGGGGTCCTTAAATCTGAAAAACCAAGGCAACCATTTTCTTAGCAACCAGGGAACCAATCAGAAACTCAGCCAAAACCACCTTGTCTAAAATAAAGCATCGCCATCCAGCTGGTTGGAAAAGGGAACGTAGGCTAATTTAAGGCAGCCATCTTGGTTTTGGTGAAATGTTAGGGAATTTTTTTTTTCCTTAAATGATTTGATAGTGTCAGCAGAATTGAACAGAGAGAGAGTA...
GAAGGGAGGGAGTTCTCTGAGGAAGAAGCCACAGCAGATTTTCCTCACAGACTTCCTTTCCCACGCAGCCTCCCACGTGGCGCTTACAGGGGTCCTTAAATCTGAAAAACCAAGGCAACCATTTTCTTAGCAACCAGGGAACCAATCAGAAACTCAGCCAAAACCACCTTGTCTAAAATAAAGCATCGCCATCCAGCTGGTTGGAAAAGGGAACGTAGGCTAATTTAAGGCAGCCATCTTGGTTTTGGTGAAATGTTAGGGAATTTTTTTTTTCCTTAAATGATTTGATAGTGTCAGCAGAATTGAACAGAGAGAGAGTA...
benign
197,069
Variant on chromosome 12, at position 51765654, affecting SCN8A (sodium voltage-gated channel alpha subunit 8): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
TTTGAAGAAGTTAGTGTTTAAGTTACTCTTAATGACTTAAAATGACTCTGAAAGAATAGTTAATGGTATCTTCAAAACAGCTGTCCGTAAACATAAGCGTAAGTGATATCTTGATTAACTCCTCGAGAAACTGAGTTATCCTGGGGGTATCCCACTCAGACAAAGGTCACTACTGCTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAAC...
TTTGAAGAAGTTAGTGTTTAAGTTACTCTTAATGACTTAAAATGACTCTGAAAGAATAGTTAATGGTATCTTCAAAACAGCTGTCCGTAAACATAAGCGTAAGTGATATCTTGATTAACTCCTCGAGAAACTGAGTTATCCTGGGGGTATCCCACTCAGACAAAGGTCACTACTGCTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAAC...
benign
197,077
Evaluate if the mutation on chromosome 12 at position 51765654 in SCN8A (sodium voltage-gated channel alpha subunit 8) is benign or pathogenic. Disease name(s) if pathogenic?
benign
TTTGAAGAAGTTAGTGTTTAAGTTACTCTTAATGACTTAAAATGACTCTGAAAGAATAGTTAATGGTATCTTCAAAACAGCTGTCCGTAAACATAAGCGTAAGTGATATCTTGATTAACTCCTCGAGAAACTGAGTTATCCTGGGGGTATCCCACTCAGACAAAGGTCACTACTGCTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAAC...
TTTGAAGAAGTTAGTGTTTAAGTTACTCTTAATGACTTAAAATGACTCTGAAAGAATAGTTAATGGTATCTTCAAAACAGCTGTCCGTAAACATAAGCGTAAGTGATATCTTGATTAACTCCTCGAGAAACTGAGTTATCCTGGGGGTATCCCACTCAGACAAAGGTCACTACTGCTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAAC...
benign
197,078
Does the variant on chromosome 12 at location 51765829 affecting gene SCN8A (sodium voltage-gated channel alpha subunit 8) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Developmental_and_epileptic_encephalopathy,_13']
CTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAACAGAGATTTCACTCAGTCAAAGTCACAAATAACTGCCAAATTTTTGAAACCTCTGTTTACTACTCTTTGGTTAGGATCCAGTCCACAGTGGACTTTTTTGAGAATAGTTATTACCTAGGTGACAAAAGAAAGGATTGAGAGTAGCCTTAGAACTTATATTCTTAATAAATTAAAAA...
CTTCCCTGGCATTAGAATTGGCTTGGGTTTTTCACTCCCTATTGGGAAGATAAGCACTTGGCAACTGAAAAGGTTTAAAGTTTCTTCATTGAGATATTCAGCAGTTCTAAGAAAGAACTGGAAAAAGTGAAACTATTTGTAAAACAGAGATTTCACTCAGTCAAAGTCACAAATAACTGCCAAATTTTTGAAACCTCTGTTTACTACTCTTTGGTTAGGATCCAGTCCACAGTGGACTTTTTTGAGAATAGTTATTACCTAGGTGACAAAAGAAAGGATTGAGAGTAGCCTTAGAACTTATATTCTTAATAAATTAAAAA...
pathogenic
197,086
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 12, position 51807428, gene SCN8A (sodium voltage-gated channel alpha subunit 8). What disease(s) is it linked to if pathogenic?
benign
TCAAGACCAGCCCGGGCAACATAGCAAGACCCCCATCTCTACAAAATATTTAAAATAAATAAATAAGACAGAAACAGTATAATTTCCTAACCATAGTAGGAAATTATATATATATATATGATTCTTACATAGTAAATCTATAAAGGCACACACTAGAATGATACATACCATCTTCAGCATTGTGGATGCTTCATCTGGGAATGATGAAAGAGGAAGAAAAATTGGTAAAATGCTAGCCTCTATTAAATCTGTGTTCCATTCCAGTTACTCAGGAGGTCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGC...
TCAAGACCAGCCCGGGCAACATAGCAAGACCCCCATCTCTACAAAATATTTAAAATAAATAAATAAGACAGAAACAGTATAATTTCCTAACCATAGTAGGAAATTATATATATATATATGATTCTTACATAGTAAATCTATAAAGGCACACACTAGAATGATACATACCATCTTCAGCATTGTGGATGCTTCATCTGGGAATGATGAAAGAGGAAGAAAAATTGGTAAAATGCTAGCCTCTATTAAATCTGTGTTCCATTCCAGTTACTCAGGAGGTCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGC...
benign
197,219
Mutation at chromosome 12, position 51913102, within ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
CTGTCAGGCTCACCATGTCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAA...
CTGTCAGGCTCACCATGTCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAA...
pathogenic
197,229
Gene mutation in ACVRL1 (activin A receptor like type 1) at chromosome 12, position 51913106—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
CAGGCTCACCATGTCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATT...
CAGGCTCACCATGTCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATT...
pathogenic
197,231
The genetic variant at chromosome 12, position 51913119, affecting gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
TCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTG...
TCATGCCAAAGGACAGTCTCCCTGCCTTGTGCCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTG...
pathogenic
197,233
Evaluate if the mutation on chromosome 12 at position 51913150 in ACVRL1 (activin A receptor like type 1) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCC...
CCCTGCCTGAGGATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCC...
pathogenic
197,240
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 12, position 51913162, gene ACVRL1 (activin A receptor like type 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
ATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCT...
ATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCT...
pathogenic
197,242
For chromosome 12, position 51913162, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
ATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCT...
ATCCAGTCCCCAGACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCT...
pathogenic
197,243
Is the genetic mutation found on chromosome 12 at position 51913174, within the gene ACVRL1 (activin A receptor like type 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGC...
GACACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGC...
pathogenic
197,245
Variant at chromosome position 51913176, chromosome 12, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
pathogenic
197,246
Located at chromosome 12 position 51913176, the variant affecting gene ACVRL1 (activin A receptor like type 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['ACVRL1-related_disorder', 'Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
pathogenic
197,247
Variant on chromosome 12, at position 51913176, affecting ACVRL1 (activin A receptor like type 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
CACACACCTGCACATGCTCCACCATTCAGAAAGTCCTGTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAA...
pathogenic
197,248
Is the genetic mutation found on chromosome 12 at position 51913213, within the gene ACVRL1 (activin A receptor like type 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGG...
GTTGCTGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGG...
pathogenic
197,255
Chromosome 12, position 51913218, gene ACVRL1 (activin A receptor like type 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
TGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCT...
TGTCTGACCAGGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCT...
pathogenic
197,256
Gene mutation in ACVRL1 (activin A receptor like type 1) at chromosome 12, position 51913228—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGG...
GGGTCCTTCTTGCTGCAGCTTTAGCCAATATCTTCTGGTTCTAAACCTGTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGG...
pathogenic
197,257
Variant at chromosome position 51913276, chromosome 12, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Cardiovascular_phenotype']
GTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGGTGAGCTTGCAGAGAGGTTTCTCTACACCTGGCATGACCCTGCCCCGTC...
GTGAGAAATGAAGACTGGGTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGGTGAGCTTGCAGAGAGGTTTCTCTACACCTGGCATGACCCTGCCCCGTC...
pathogenic
197,264
Chromosome 12, position 51913294, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
GTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGGTGAGCTTGCAGAGAGGTTTCTCTACACCTGGCATGACCCTGCCCCGTCCGAGCTTTGCATGGTTGT...
GTGGCTTCAGAAGCACTAGTTGGTGTGGGACCTGGATTGGGGACTATCATAGACCAGAATTACTCCCCCTAACACTCTCCAACAAACTTCTGGAAAAGTTCAACCCTAGTCAGCCATGGAAGGTCAAACATTCAGTGTCTAAGTGTGTTTCACTTCCCCTGCCACATCACTGGCCCTCCACCCACCCTTTCCTAGATGGCAAGGGGAAAGAAGGGGGCCAGGGAACAGCTCCGAGAGGGCAGCTTATACTCTGGTGAGCTTGCAGAGAGGTTTCTCTACACCTGGCATGACCCTGCCCCGTCCGAGCTTTGCATGGTTGT...
pathogenic
197,265
Considering the genetic mutation at chromosome 12, position 51913592, impacting ACVRL1 (activin A receptor like type 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CGTCCGAGCTTTGCATGGTTGTTATAGCCCTGAGGGCTCAGACATGGGCTGCCACCACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACC...
CGTCCGAGCTTTGCATGGTTGTTATAGCCCTGAGGGCTCAGACATGGGCTGCCACCACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACC...
pathogenic
197,282
A mutation at chromosome position 51913616 on chromosome 12 in gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
TAGCCCTGAGGGCTCAGACATGGGCTGCCACCACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTG...
TAGCCCTGAGGGCTCAGACATGGGCTGCCACCACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTG...
pathogenic
197,283
Does the variant impacting ACVRL1 (activin A receptor like type 1) on chromosome 12, position 51913648, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['ACVRL1-related_disorder', 'Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
ACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGA...
ACTGGATAGGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGA...
pathogenic
197,286
Variant at chromosome 12, position 51913656, gene ACVRL1 (activin A receptor like type 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGACTCCTGCC...
GGGACAGAGCGAAGAGAGCACTTGATTAGGAGTCTGGAAACCTGGGATGTACGCCTGCTGGTGCCAGTGAGTCCTGTCTGACCCGGGACAAGTCTTCTTCCCTGTATGAGCCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGACTCCTGCC...
pathogenic
197,287
Is the genetic change at chromosome 12, position 51913766, within gene ACVRL1 (activin A receptor like type 1) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGACTCCTGCCTGTTCTATCCAGACCCCAATCTAAACAATCTTGATTCCTGTTCCTGGCTTGGCAGGACCCTGAATGGCAGGAAGCGAAGACAGGAGCCTGTTTATGTTTGAGGCAGCCAG...
CCTTACTCCTCTCTTCTGTAAAACAAGGAGCTGGATTTTGTGATTCACAGGATGTCCACCTAGAATTCTGTCATGTGGGTGTCCCAGGCACAAGGAACTAAGGGTAGCAAGGAACTAAGGGCATATTTAAAAAGCCCCTCCAGACCTTGTGGCTGCTGCAGCCCACCCTGAAAATATGCCCTCAGTTCCCTGCTGTGCGTGACTCCTGCCTGTTCTATCCAGACCCCAATCTAAACAATCTTGATTCCTGTTCCTGGCTTGGCAGGACCCTGAATGGCAGGAAGCGAAGACAGGAGCCTGTTTATGTTTGAGGCAGCCAG...
pathogenic
197,292
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 12, position 51913988, gene ACVRL1 (activin A receptor like type 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['ACVRL1-related_disorder', 'Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
ACCCCAATCTAAACAATCTTGATTCCTGTTCCTGGCTTGGCAGGACCCTGAATGGCAGGAAGCGAAGACAGGAGCCTGTTTATGTTTGAGGCAGCCAGGGCTGGGGGGGCATTGAGAAAGGGTAGGCAGGGGTGGAAGCTGTGAGGGAGTGGGAAAGAGACACAGAACAGAAGGGGAGCTGCTGGAGAGATGCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTT...
ACCCCAATCTAAACAATCTTGATTCCTGTTCCTGGCTTGGCAGGACCCTGAATGGCAGGAAGCGAAGACAGGAGCCTGTTTATGTTTGAGGCAGCCAGGGCTGGGGGGGCATTGAGAAAGGGTAGGCAGGGGTGGAAGCTGTGAGGGAGTGGGAAAGAGACACAGAACAGAAGGGGAGCTGCTGGAGAGATGCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTT...
pathogenic
197,298
Clinically, how would you classify the variant at chromosome 12, position 51914067, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
TTATGTTTGAGGCAGCCAGGGCTGGGGGGGCATTGAGAAAGGGTAGGCAGGGGTGGAAGCTGTGAGGGAGTGGGAAAGAGACACAGAACAGAAGGGGAGCTGCTGGAGAGATGCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTTCACCTCTAACAGGATGGTTTCCATGGGGAAGTGAACCAGGACTTCCCCTGCAGGCCCCGCCCCAAAGCCAGGCGGCAGG...
TTATGTTTGAGGCAGCCAGGGCTGGGGGGGCATTGAGAAAGGGTAGGCAGGGGTGGAAGCTGTGAGGGAGTGGGAAAGAGACACAGAACAGAAGGGGAGCTGCTGGAGAGATGCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTTCACCTCTAACAGGATGGTTTCCATGGGGAAGTGAACCAGGACTTCCCCTGCAGGCCCCGCCCCAAAGCCAGGCGGCAGG...
pathogenic
197,303
Clinically, how would you classify the variant at chromosome 12, position 51914179, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
GCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTTCACCTCTAACAGGATGGTTTCCATGGGGAAGTGAACCAGGACTTCCCCTGCAGGCCCCGCCCCAAAGCCAGGCGGCAGGGAGTAGGGAGGCGGCCTCCCTGCCTCCCCTCCAAAAAAAACTCTGTGATTTCCTCTGGGCAGGAGGGAGCCACGGCCAGCGGCTGTCACACTTCATGGCTCTTACTCCACCT...
GCTCCTTCTACCCCAATTGGGTGCTCCCTGCGGCTCTCCCAACCTGCCTGCAGTCTGAGCTCAGCAGCAGGAGTGCAGAGCTAGGGTTTCCCCAAGCTCTCAGTCACTTAAACATTGCTCTCCACCCTTCACCTCTAACAGGATGGTTTCCATGGGGAAGTGAACCAGGACTTCCCCTGCAGGCCCCGCCCCAAAGCCAGGCGGCAGGGAGTAGGGAGGCGGCCTCCCTGCCTCCCCTCCAAAAAAAACTCTGTGATTTCCTCTGGGCAGGAGGGAGCCACGGCCAGCGGCTGTCACACTTCATGGCTCTTACTCCACCT...
benign
197,306
Variant on chromosome 12, at position 51914452, affecting ACVRL1 (activin A receptor like type 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
GGAGCCACGGCCAGCGGCTGTCACACTTCATGGCTCTTACTCCACCTCTCTTGCTCCTCTCTGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCC...
GGAGCCACGGCCAGCGGCTGTCACACTTCATGGCTCTTACTCCACCTCTCTTGCTCCTCTCTGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCC...
pathogenic
197,314
Located at chromosome 12 position 51914505, the variant affecting gene ACVRL1 (activin A receptor like type 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2', 'likely other unspecified diseases']
CTCCTCTCTGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTAT...
CTCCTCTCTGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTAT...
pathogenic
197,325
For chromosome 12, position 51914513, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
TGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGG...
TGCAGGGACCATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGG...
pathogenic
197,327
Considering the genetic mutation at chromosome 12, position 51914552, impacting ACVRL1 (activin A receptor like type 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Telangiectasia', 'Telangiectasia,_hereditary_hemorrhagic,_type_2', 'likely other unspecified diseases']
TCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGGTGGAGGGAGAGCAGGTGTTGGCAGGCCAAGCCTGGGAGA...
TCTGATGCTGCTGATGGCCTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGGTGGAGGGAGAGCAGGTGTTGGCAGGCCAAGCCTGGGAGA...
pathogenic
197,332
Variant on chromosome 12, at position 51914570, affecting ACVRL1 (activin A receptor like type 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Pulmonary_arterial_hypertension_related_to_hereditary_hemorrhagic_telangiectasia', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGGTGGAGGGAGAGCAGGTGTTGGCAGGCCAAGCCTGGGAGAGCACTCAGGGCTGGGGCT...
CTTGGTGACCCAGGGTGAGTACTGGGGGAGCAGTTAGGAAACAGGAACCTGGATACAGAAAGGGCTATCTGGGCCCAGATCAGCTCTGCCTGGGGCTGAACTTGAGAAGCTGGGGAGAATGTAGGAGCTTGACTGGAGAGTGGAGGACAGTGAGGCTCCATTAGACTCAGTCCCCAGCTACCCCAGCCCTCCTTTGCTCTCCTCTTGATCCAGACCTGCAGGCTGGAGCTCTGTCAGACTAGGGTGGAAGCCTATATGTGGGGTGGAGGGAGAGCAGGTGTTGGCAGGCCAAGCCTGGGAGAGCACTCAGGGCTGGGGCT...
pathogenic
197,334
The mutation in gene ACVRL1 (activin A receptor like type 1) at chromosome 12, position 51915257—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GAGGAGGGGAGGCACCCCCAGGAACATCGGGGCTGCGGGAACTTGCACAGGGAGCTCTGCAGGGGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGG...
GAGGAGGGGAGGCACCCCCAGGAACATCGGGGCTGCGGGAACTTGCACAGGGAGCTCTGCAGGGGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGG...
pathogenic
197,342
Considering the genetic mutation at chromosome 12, position 51915299, impacting ACVRL1 (activin A receptor like type 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
TTGCACAGGGAGCTCTGCAGGGGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTC...
TTGCACAGGGAGCTCTGCAGGGGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTC...
pathogenic
197,351
Variant in ACVRL1 (activin A receptor like type 1), chromosome 12, position 51915320—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Cardiovascular_phenotype', 'Hereditary_hemorrhagic_telangiectasia', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAG...
GGGCGCCCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAG...
pathogenic
197,354
Variant chromosome 12, position 51915337, gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? Disease(s)?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTG...
CGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCCCTGGTGCTGGAGGGTACGTCCAGCTGCCCTAGCACTCCCTCCCCATCTTCTTGGCCCCTGCCCTCCCTTCCCTCCTTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTG...
pathogenic
197,357
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 12, position 51915461, gene ACVRL1 (activin A receptor like type 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
TTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCA...
TTTCCTCTCATGCTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCA...
pathogenic
197,379
Does the variant on chromosome 12 at location 51915473 affecting gene ACVRL1 (activin A receptor like type 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCAT...
CTCTGGCCAATAAAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCAT...
pathogenic
197,380
A genetic alteration at chromosome 12, position 51915485, in gene ACVRL1 (activin A receptor like type 1)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
AAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCATCTGAGCAGGGCG...
AAGGGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCATCTGAGCAGGGCG...
pathogenic
197,386
Is the chromosome 12, position 51915488 variant in ACVRL1 (activin A receptor like type 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
GGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCATCTGAGCAGGGCGACA...
GGGCTGGGGGCGGGGGAGCGGGTGGGCAGGACTCTGGGATCTAACTGGCAGAGTGGTCTGGCCCGAGGTGGGGGGAGCTGACCTAGTGGAAGCTGAGCCTCAGTGTCCCCCTCCCTCAGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCCCTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTGTGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCCAGTCTCATCCTGAAAGCATCTGAGCAGGGCGACA...
pathogenic
197,387
Is the genetic change at chromosome 12, position 51916107, within gene ACVRL1 (activin A receptor like type 1) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Cardiovascular_phenotype']
TGGTGGAGTGTGTGGGTGAGCAGTGGGTGAGCCCGGTGGATGAGGACCAAGGGCTCTCATGAGCCTGGAGGGGTGAGGGAGTTTTTGGCTACTGGAATCACAGGCGGTGCCAGGCCTGGGTCAGAATTGGAATTCTGCTGGGCAGGGAGTGGGCTGGAGACGGGCCAGGGCTAGGTTCTTCTTTCTGCAGGACCGGGGTGGAACGAGAGGCAGCTGGGGGTGGCCTGCCACTGGGTTTGGGTCTGGATTAAGTTAAACCTAAGGGTCTGGGGTTCTGTGGGTGGGGTGGGCGAGGGAGGCAGCGCAGCATCAAGATGGGG...
TGGTGGAGTGTGTGGGTGAGCAGTGGGTGAGCCCGGTGGATGAGGACCAAGGGCTCTCATGAGCCTGGAGGGGTGAGGGAGTTTTTGGCTACTGGAATCACAGGCGGTGCCAGGCCTGGGTCAGAATTGGAATTCTGCTGGGCAGGGAGTGGGCTGGAGACGGGCCAGGGCTAGGTTCTTCTTTCTGCAGGACCGGGGTGGAACGAGAGGCAGCTGGGGGTGGCCTGCCACTGGGTTTGGGTCTGGATTAAGTTAAACCTAAGGGTCTGGGGTTCTGTGGGTGGGGTGGGCGAGGGAGGCAGCGCAGCATCAAGATGGGG...
pathogenic
197,403
Determine if the mutation at chromosome 12, position 51916138 in gene ACVRL1 (activin A receptor like type 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
CCCGGTGGATGAGGACCAAGGGCTCTCATGAGCCTGGAGGGGTGAGGGAGTTTTTGGCTACTGGAATCACAGGCGGTGCCAGGCCTGGGTCAGAATTGGAATTCTGCTGGGCAGGGAGTGGGCTGGAGACGGGCCAGGGCTAGGTTCTTCTTTCTGCAGGACCGGGGTGGAACGAGAGGCAGCTGGGGGTGGCCTGCCACTGGGTTTGGGTCTGGATTAAGTTAAACCTAAGGGTCTGGGGTTCTGTGGGTGGGGTGGGCGAGGGAGGCAGCGCAGCATCAAGATGGGGGGCTCTTCCAGGGCTCTGTGTGCCCAGTGTG...
CCCGGTGGATGAGGACCAAGGGCTCTCATGAGCCTGGAGGGGTGAGGGAGTTTTTGGCTACTGGAATCACAGGCGGTGCCAGGCCTGGGTCAGAATTGGAATTCTGCTGGGCAGGGAGTGGGCTGGAGACGGGCCAGGGCTAGGTTCTTCTTTCTGCAGGACCGGGGTGGAACGAGAGGCAGCTGGGGGTGGCCTGCCACTGGGTTTGGGTCTGGATTAAGTTAAACCTAAGGGTCTGGGGTTCTGTGGGTGGGGTGGGCGAGGGAGGCAGCGCAGCATCAAGATGGGGGGCTCTTCCAGGGCTCTGTGTGCCCAGTGTG...
pathogenic
197,414
Variant on chromosome 12, at position 51918985, affecting ACVRL1 (activin A receptor like type 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
GCACTCCAGTCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAAAGAAAATTTATTAAAATAAATAAATAAAATGAGAATAAAAATAGCTTCCAGTTGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGG...
GCACTCCAGTCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAAAGAAAATTTATTAAAATAAATAAATAAAATGAGAATAAAAATAGCTTCCAGTTGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGG...
pathogenic
197,439
Is the genetic variant on chromosome 12, position 51919061, gene ACVRL1 (activin A receptor like type 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
AATAAAAATAGCTTCCAGTTGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGG...
AATAAAAATAGCTTCCAGTTGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGG...
pathogenic
197,449
Gene ACVRL1 (activin A receptor like type 1) variant at chromosome position 51919080 on chromosome 12: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Telangiectasia,_hereditary_hemorrhagic,_type_2']
TGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTG...
TGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTG...
pathogenic
197,451
Evaluate the clinical significance of the mutation at chromosome 12, position 51919080 in gene ACVRL1 (activin A receptor like type 1): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Cardiovascular_phenotype', 'Telangiectasia,_hereditary_hemorrhagic,_type_2']
TGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTG...
TGTTGAGATAATCTAAGTATTTAGAACAGTATCTAGAGCTAAATATTAGTGGCTGTTATTGTTGTAGATAGAATGAGTGCCTGACATCATATTGTCCCCATTTTACAGTTGAGGAGACGGGGGCACAGAATGACAGTGGGCTTGAGGCAGCATCAGGGTCCGAAACCGGGCAGTCTGCCCCGGGGCCAGTGCTCATCATCACTGTGTGCACTTAAACCTCTCTGGCCCTTGATTTCCTCATGCACGCAATGCATGTGAGTGCCTGCACTGCCTGCTTATTGCTGCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTG...
pathogenic
197,452
The mutation impacting ACVRL1 (activin A receptor like type 1) on chromosome 12 at position 51919363: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
GCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTGATTTAGAGGGACTGCGACAGGTAGAGAGACCTGCCCTGGGCAGGCAGCCCTGAGGTCGATGTTCTCTCAGCCCTGGAGTGGACGGAGGATAGGTGGGTCGTCTAGACTGGTGGGAGCATTGTCAACCTTTGAGGAGGCTGTCCATGGTGAGGGACTTCCAGGAGTCGTGACAGGTTGGGGACAATCCTCAGGATATGGCTGGAGCCCTGCTTCTTGGGGACAAGGATGTCCTCATTTCCTGAGCATCTACCAGGAGCCAGCCCCATGCCAGACTTCATTTGTC...
GCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTGATTTAGAGGGACTGCGACAGGTAGAGAGACCTGCCCTGGGCAGGCAGCCCTGAGGTCGATGTTCTCTCAGCCCTGGAGTGGACGGAGGATAGGTGGGTCGTCTAGACTGGTGGGAGCATTGTCAACCTTTGAGGAGGCTGTCCATGGTGAGGGACTTCCAGGAGTCGTGACAGGTTGGGGACAATCCTCAGGATATGGCTGGAGCCCTGCTTCTTGGGGACAAGGATGTCCTCATTTCCTGAGCATCTACCAGGAGCCAGCCCCATGCCAGACTTCATTTGTC...
benign
197,459
Is the genetic variant on chromosome 12, position 51919363, gene ACVRL1 (activin A receptor like type 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
GCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTGATTTAGAGGGACTGCGACAGGTAGAGAGACCTGCCCTGGGCAGGCAGCCCTGAGGTCGATGTTCTCTCAGCCCTGGAGTGGACGGAGGATAGGTGGGTCGTCTAGACTGGTGGGAGCATTGTCAACCTTTGAGGAGGCTGTCCATGGTGAGGGACTTCCAGGAGTCGTGACAGGTTGGGGACAATCCTCAGGATATGGCTGGAGCCCTGCTTCTTGGGGACAAGGATGTCCTCATTTCCTGAGCATCTACCAGGAGCCAGCCCCATGCCAGACTTCATTTGTC...
GCCTGGTTGTTACTGTGGGTTGCCACAGGGGACTCTGATTTAGAGGGACTGCGACAGGTAGAGAGACCTGCCCTGGGCAGGCAGCCCTGAGGTCGATGTTCTCTCAGCCCTGGAGTGGACGGAGGATAGGTGGGTCGTCTAGACTGGTGGGAGCATTGTCAACCTTTGAGGAGGCTGTCCATGGTGAGGGACTTCCAGGAGTCGTGACAGGTTGGGGACAATCCTCAGGATATGGCTGGAGCCCTGCTTCTTGGGGACAAGGATGTCCTCATTTCCTGAGCATCTACCAGGAGCCAGCCCCATGCCAGACTTCATTTGTC...
benign
197,460
Located at chromosome 12 position 51920505, the variant affecting gene ACVRL1 (activin A receptor like type 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
GCTCTTAGGACAGCACCTGGCATACAGTGCTCAGTAAACATTTGGTGTTATTATTATCAGGCATGTGTGATAGTTGGGGCCTGGGAGCAGTCCCGGGCACTGGGTGGAAGGCAGCTGAGGGAAGACTGGAACAAGGCTGGCCTAGGAATCCGAGATGGGTTTGAGTCTTGCCTCTGCCATTACTAGCTGTGGAACCTTGGGCCCCCCTTCTCTGAGCATCAGTTTCTTCATCTGTAAAATGGAGGTAATACTAGTACCCACCCCACAGGGCTGTTGTGAGGACAAACAGGATAAAGCATGTAAAGTGTTTACAGCAGAAT...
GCTCTTAGGACAGCACCTGGCATACAGTGCTCAGTAAACATTTGGTGTTATTATTATCAGGCATGTGTGATAGTTGGGGCCTGGGAGCAGTCCCGGGCACTGGGTGGAAGGCAGCTGAGGGAAGACTGGAACAAGGCTGGCCTAGGAATCCGAGATGGGTTTGAGTCTTGCCTCTGCCATTACTAGCTGTGGAACCTTGGGCCCCCCTTCTCTGAGCATCAGTTTCTTCATCTGTAAAATGGAGGTAATACTAGTACCCACCCCACAGGGCTGTTGTGAGGACAAACAGGATAAAGCATGTAAAGTGTTTACAGCAGAAT...
benign
197,465
Considering the genetic mutation at chromosome 12, position 51920931, impacting ACVRL1 (activin A receptor like type 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
GGTTTCTGGCCCTTGGATAGAGGGTAGAAAAGGCTCTCCTCTGGGTGGTATTGGGCCTCCTTAGAGTCCCAAGTGATTGTCCTGTCCATTCTCCATTTCCAGGCATCGTGGAGGACTATAGACCACCCTTCTATGATGTGGTGCCCAATGACCCCAGCTTTGAGGACATGAAGAAGGTGGTGTGTGTGGATCAGCAGACCCCCACCATCCCTAACCGGCTGGCTGCAGACCCGGTGAGGCCTCTGCTGGGACTAGGATGGCGTGGGGTGGTGGCTCATGGCTGGGATTTCTGGGCCCAGGAACTTGTGTCTGAGGCCTCT...
GGTTTCTGGCCCTTGGATAGAGGGTAGAAAAGGCTCTCCTCTGGGTGGTATTGGGCCTCCTTAGAGTCCCAAGTGATTGTCCTGTCCATTCTCCATTTCCAGGCATCGTGGAGGACTATAGACCACCCTTCTATGATGTGGTGCCCAATGACCCCAGCTTTGAGGACATGAAGAAGGTGGTGTGTGTGGATCAGCAGACCCCCACCATCCCTAACCGGCTGGCTGCAGACCCGGTGAGGCCTCTGCTGGGACTAGGATGGCGTGGGGTGGTGGCTCATGGCTGGGATTTCTGGGCCCAGGAACTTGTGTCTGAGGCCTCT...
benign
197,490
Determine if the mutation at chromosome 12, position 52451560 in gene KRT6B (keratin 6B) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Pachyonychia_congenita_4']
GCAATCTCCTCATATTGGGCCTTGACCTCAGCGATGATGCTGTCCAGGTCCAGGTTGCGGTTGTTGTCCATGGATAGCACCACGGATGTGTCTGAGATGTGGGTCTGCATCTGGGACAGCTCCTGCAGAACAGAAGGTCATAAGATCAACTTCACTTCTGACATTTACAGAGATGCCCAGCCCTGTACATCTTCTCCCCTTTGCAGACCCCATCAGAGTAAACAGAAGGATGGTGGAGTTGCTTACTGCATCATACAAGGCTCTCAGGAAGTTGATCTCATCTGTAAGAGTGTCTGCCTTGGCTTGCAGTTCAACCTTGT...
GCAATCTCCTCATATTGGGCCTTGACCTCAGCGATGATGCTGTCCAGGTCCAGGTTGCGGTTGTTGTCCATGGATAGCACCACGGATGTGTCTGAGATGTGGGTCTGCATCTGGGACAGCTCCTGCAGAACAGAAGGTCATAAGATCAACTTCACTTCTGACATTTACAGAGATGCCCAGCCCTGTACATCTTCTCCCCTTTGCAGACCCCATCAGAGTAAACAGAAGGATGGTGGAGTTGCTTACTGCATCATACAAGGCTCTCAGGAAGTTGATCTCATCTGTAAGAGTGTCTGCCTTGGCTTGCAGTTCAACCTTGT...
pathogenic
197,667
Evaluate if the mutation on chromosome 12 at position 52515065 in KRT5 (keratin 5) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Epidermolysis_bullosa_simplex', 'Epidermolysis_bullosa_simplex_with_migratory_circinate_erythema', 'Epidermolysis_bullosa_simplex_with_mottled_pigmentation', 'KRT5-related_disorder']
TTAAAACAAAGATCCATAATTTGATACAATTGGAAATCCAAAATTGGCTAAAATAATTTATACATCTAAAAGATAAAAAGGTGTGCAGGCTGTCTTGGTGTCTCCACCACATAAATTCTGAATTTACTTTCACATTTGCTGACATACAATAATTGACAATTCTTCATGGTCTTAATCCATACTGAAGCTCAAATAATACTTATACCTGGGGATCCTATTAAATTTAAACAAGGTACCCCTGTAATCTTGGGGAAGTTAATGAACAAAAAATAGAGAACAAACAGGCATGCCTCACTTTAATTAGCAGAACTACTGACTTG...
TTAAAACAAAGATCCATAATTTGATACAATTGGAAATCCAAAATTGGCTAAAATAATTTATACATCTAAAAGATAAAAAGGTGTGCAGGCTGTCTTGGTGTCTCCACCACATAAATTCTGAATTTACTTTCACATTTGCTGACATACAATAATTGACAATTCTTCATGGTCTTAATCCATACTGAAGCTCAAATAATACTTATACCTGGGGATCCTATTAAATTTAAACAAGGTACCCCTGTAATCTTGGGGAAGTTAATGAACAAAAAATAGAGAACAAACAGGCATGCCTCACTTTAATTAGCAGAACTACTGACTTG...
pathogenic
197,731
Does the variant impacting KRT71 (keratin 71) on chromosome 12, position 52548000, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
CAGATCAGGAAGAGGGAACAAGAATGCCTAATAGAGTAATGGGGTTTTGCAGGGAGCAGGGCGGTGGTTGTTTCTAGTATGCCCAGGAAGAACGAGCAAATCTGCATAGCTTACTACATAGCATAGTGCCTGCCATGAAGCAAGCTCTCACAGTCTACTGAGTGGATACTCATGTCCACTCATGGTAGTATTGTTAATTACTGTGATTATTTCTATCCTCATCACCCCATCACTTCCTAAGAACTCATCTCTTCTGGATTGAGATGTGTTAGGCTTTCTCCTTTGGGTCTTCCCAAACCCCTGGGGCCCTCCTGTCTGGG...
CAGATCAGGAAGAGGGAACAAGAATGCCTAATAGAGTAATGGGGTTTTGCAGGGAGCAGGGCGGTGGTTGTTTCTAGTATGCCCAGGAAGAACGAGCAAATCTGCATAGCTTACTACATAGCATAGTGCCTGCCATGAAGCAAGCTCTCACAGTCTACTGAGTGGATACTCATGTCCACTCATGGTAGTATTGTTAATTACTGTGATTATTTCTATCCTCATCACCCCATCACTTCCTAAGAACTCATCTCTTCTGGATTGAGATGTGTTAGGCTTTCTCCTTTGGGTCTTCCCAAACCCCTGGGGCCCTCCTGTCTGGG...
benign
197,805
Is the chromosome 12, position 52651839 variant in KRT2 (keratin 2) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
CTCACTCCTTTCTCTGGCTGCTGCTTTTGCACTCACAGTTGATTTCCAAACTGGCTGCTTAGACACAATGGGGCTGTGAAGCACTCCTATCCCCACCCCCAGCCAAGACATTCTCTCGCTCACCTTTTTAAGCGTCACAAAATCATTCTCAGCAGCTGTGCGCTTATTGATTTCATCCTCATACCTATTGGGACACAGATGTTACAGCAGTTAGATTAGTTCCCCTTCATTTTTTTTCTTTTCCTTTTATACTGGATTCACCCCAAATGCCCCATTCTCTGGGAATATTACACACTTTTTAAATATCTAAATTGAAACTA...
CTCACTCCTTTCTCTGGCTGCTGCTTTTGCACTCACAGTTGATTTCCAAACTGGCTGCTTAGACACAATGGGGCTGTGAAGCACTCCTATCCCCACCCCCAGCCAAGACATTCTCTCGCTCACCTTTTTAAGCGTCACAAAATCATTCTCAGCAGCTGTGCGCTTATTGATTTCATCCTCATACCTATTGGGACACAGATGTTACAGCAGTTAGATTAGTTCCCCTTCATTTTTTTTCTTTTCCTTTTATACTGGATTCACCCCAAATGCCCCATTCTCTGGGAATATTACACACTTTTTAAATATCTAAATTGAAACTA...
benign
197,899
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 12, position 52675438, gene KRT1 (keratin 1). What disease(s) is it linked to if pathogenic?
benign
AGACGAGTTTAAGGAATTTGGCTCAGGGCGAAGGCTAGTTTCTGTGTGTTTAACAAAAGGGCTATTTCCCAGTGTTTCCCAGCAACAACTAAACAGCTTTGTCAGTGCCTGAGAATGCCCGAGACCCAGCTTTGCTTCAAGCCTGCAAAGGAAAGCATGCAGCTGGCCAAGTGATGGAGTAGACAAGGCACACTGTGTTTCCCGGTCAGGACACAGAAAGACAGCAGGGGACACTGGGGTCCCTACAGAAGGGATAACTGAGAAGGAAGAATAGAGCTCACCTGAGTTGTGTTTGCATAATACATGTGTGATCTATCCTC...
AGACGAGTTTAAGGAATTTGGCTCAGGGCGAAGGCTAGTTTCTGTGTGTTTAACAAAAGGGCTATTTCCCAGTGTTTCCCAGCAACAACTAAACAGCTTTGTCAGTGCCTGAGAATGCCCGAGACCCAGCTTTGCTTCAAGCCTGCAAAGGAAAGCATGCAGCTGGCCAAGTGATGGAGTAGACAAGGCACACTGTGTTTCCCGGTCAGGACACAGAAAGACAGCAGGGGACACTGGGGTCCCTACAGAAGGGATAACTGAGAAGGAAGAATAGAGCTCACCTGAGTTGTGTTTGCATAATACATGTGTGATCTATCCTC...
benign
197,909
Does the variant impacting KRT4 (keratin 4) on chromosome 12, position 52813799, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
CTCCCCATGTACTTAGTCTTGAAGTCCTCCACGCTGTCCTGCATGGTCTTCAGCTCAGACTGCAGGCGCCCTTTGTCATTGCCCAAGGTATCTAGCTGCTTCCTCAGGACACTGAGGTAGGTCTCAAAGAGGGGCTCAAGGTTTTTGCTGGAGGTGGTGGTCGTCTGCTGCTGGAGCAGGTTCCATTTGGTCTCCAGGACCTTATTCTGTTGCTCTAAGAACTGCACCTGTGTTGATAAAGGCACCAGCCAAGTGATGAGGGCCTGAAGTGTGGCAGGAGGGCCAGCCAAGGCAACACCAACCCAGTCAATCCCAGGGAA...
CTCCCCATGTACTTAGTCTTGAAGTCCTCCACGCTGTCCTGCATGGTCTTCAGCTCAGACTGCAGGCGCCCTTTGTCATTGCCCAAGGTATCTAGCTGCTTCCTCAGGACACTGAGGTAGGTCTCAAAGAGGGGCTCAAGGTTTTTGCTGGAGGTGGTGGTCGTCTGCTGCTGGAGCAGGTTCCATTTGGTCTCCAGGACCTTATTCTGTTGCTCTAAGAACTGCACCTGTGTTGATAAAGGCACCAGCCAAGTGATGAGGGCCTGAAGTGTGGCAGGAGGGCCAGCCAAGGCAACACCAACCCAGTCAATCCCAGGGAA...
benign
197,976
A genetic variant at chromosome 12, position 53307894, affecting gene AAAS (aladin WD repeat nucleoporin)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
CATGTAAGATTTCACATAAGTAGCAGGTAGCCTCAAGAAGGTTTCCCCTGCTGCTGCCTTAGATGTATGAGAACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCACTACCCTGAGTGCACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGTAAGGTGGCCTGGGAGGAGACCCGGAGACCTGTAAGAACCTTGGGTGGGGGGAAAATGGGAGCATTTGCTCCTCCTAAGCCCTAGCAAATTCCAAGTTTGGGCC...
CATGTAAGATTTCACATAAGTAGCAGGTAGCCTCAAGAAGGTTTCCCCTGCTGCTGCCTTAGATGTATGAGAACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCACTACCCTGAGTGCACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGTAAGGTGGCCTGGGAGGAGACCCGGAGACCTGTAAGAACCTTGGGTGGGGGGAAAATGGGAGCATTTGCTCCTCCTAAGCCCTAGCAAATTCCAAGTTTGGGCC...
pathogenic
198,055
Is chromosome 12, position 53308339, gene AAAS (aladin WD repeat nucleoporin) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['AAAS-related_disorder', 'Glucocorticoid_deficiency_with_achalasia']
GTGGAAGAGGCCCTTGCCCAGCGATTCCAGGTATAGGCCTTGGAGGAGGCATTATGGCTTGAGGATTACTGACTGCCAATCAACAGGAACTCCTGCTTCTTCTACCCTAAACCCTGGAGTGCAGTGGCAGACAACCTCAACCTCTTAGGCTCAAGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCTCACCCAGCTAATTTTTGTATTTTTTGTAGAGACAGGGTCTTACTTTGTTGCCTAGGCTAGTCTCAAATTCCTGGGCTCAACTGATCCTCCCACCTCAGCCTCCCAAAATGT...
GTGGAAGAGGCCCTTGCCCAGCGATTCCAGGTATAGGCCTTGGAGGAGGCATTATGGCTTGAGGATTACTGACTGCCAATCAACAGGAACTCCTGCTTCTTCTACCCTAAACCCTGGAGTGCAGTGGCAGACAACCTCAACCTCTTAGGCTCAAGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCTCACCCAGCTAATTTTTGTATTTTTTGTAGAGACAGGGTCTTACTTTGTTGCCTAGGCTAGTCTCAAATTCCTGGGCTCAACTGATCCTCCCACCTCAGCCTCCCAAAATGT...
pathogenic
198,058
Clinical significance of chromosome 12, position 53308468, gene AAAS (aladin WD repeat nucleoporin): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
GACAACCTCAACCTCTTAGGCTCAAGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCTCACCCAGCTAATTTTTGTATTTTTTGTAGAGACAGGGTCTTACTTTGTTGCCTAGGCTAGTCTCAAATTCCTGGGCTCAACTGATCCTCCCACCTCAGCCTCCCAAAATGTTGTGACTACAAACATGATCACCATGCCCAGCCTACCTTAAACCTTCTAGCTATGCTCTCCCTCTTTCAGGTGGACCCAAGTGGAGAGATTGTGGAACTGGCGAAAGGTGCATGTCCCTGGAAGGAGCAT...
GACAACCTCAACCTCTTAGGCTCAAGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCTCACCCAGCTAATTTTTGTATTTTTTGTAGAGACAGGGTCTTACTTTGTTGCCTAGGCTAGTCTCAAATTCCTGGGCTCAACTGATCCTCCCACCTCAGCCTCCCAAAATGTTGTGACTACAAACATGATCACCATGCCCAGCCTACCTTAAACCTTCTAGCTATGCTCTCCCTCTTTCAGGTGGACCCAAGTGGAGAGATTGTGGAACTGGCGAAAGGTGCATGTCCCTGGAAGGAGCAT...
pathogenic
198,060
Regarding the variant found on chromosome 12 at position 53308744 in gene AAAS (aladin WD repeat nucleoporin): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['AAAS-related_disorder']
AGATTGTGGAACTGGCGAAAGGTGCATGTCCCTGGAAGGAGCATCTCTACCACCTGGAATCTGGGCTGTCCCCTCCAGTGGCCATCTTCTTTGTTATCTACACTGACCAGGCTGGACAGTGGCGAATACAGTGTGTGCCCAAGGAGCCCCACTCATTCCAAAGCCGGTGAGGCCCTAGGGAACCACTCTGCAGACCTTCAGGCTTGTCTCAGCCTTGTTAAGAGAAGGCTGCCAACTCTGACCCCTGCTGTACTCCCTCTTTCTGCCCAGGCTGCCCCTGCCAGAGCCATGGCGGGGTCTTCGGGACGAGGCCCTGGACC...
AGATTGTGGAACTGGCGAAAGGTGCATGTCCCTGGAAGGAGCATCTCTACCACCTGGAATCTGGGCTGTCCCCTCCAGTGGCCATCTTCTTTGTTATCTACACTGACCAGGCTGGACAGTGGCGAATACAGTGTGTGCCCAAGGAGCCCCACTCATTCCAAAGCCGGTGAGGCCCTAGGGAACCACTCTGCAGACCTTCAGGCTTGTCTCAGCCTTGTTAAGAGAAGGCTGCCAACTCTGACCCCTGCTGTACTCCCTCTTTCTGCCCAGGCTGCCCCTGCCAGAGCCATGGCGGGGTCTTCGGGACGAGGCCCTGGACC...
pathogenic
198,062
The genetic variant at chromosome 12, position 53309018, affecting gene AAAS (aladin WD repeat nucleoporin): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
CCCCTGCCAGAGCCATGGCGGGGTCTTCGGGACGAGGCCCTGGACCAGGTCAGTGGGATCCCTGGCTGCATCTTCGTCCATGCAAGCGGCTTCACTGGCGGTCACCACACCCGAGAGGGTGCCTTGAGCATGGCCCGTGCCACCTTGGCCCAGCGCTCATACCTCCCACAAATCTCCTAGTCTAATAAAACCTTCCATCTCATACTGACCCAGTCCTTGACTTATTCTTGCCCTACACCATTCCAGAAACTTGTGAAAAGTGAAACAACTATTTATGTGTAAGACCCTGTGCTAGATATATTTTCTTCACAGTAACTTCT...
CCCCTGCCAGAGCCATGGCGGGGTCTTCGGGACGAGGCCCTGGACCAGGTCAGTGGGATCCCTGGCTGCATCTTCGTCCATGCAAGCGGCTTCACTGGCGGTCACCACACCCGAGAGGGTGCCTTGAGCATGGCCCGTGCCACCTTGGCCCAGCGCTCATACCTCCCACAAATCTCCTAGTCTAATAAAACCTTCCATCTCATACTGACCCAGTCCTTGACTTATTCTTGCCCTACACCATTCCAGAAACTTGTGAAAAGTGAAACAACTATTTATGTGTAAGACCCTGTGCTAGATATATTTTCTTCACAGTAACTTCT...
pathogenic
198,064
Does the variant impacting AAAS (aladin WD repeat nucleoporin) on chromosome 12, position 53309639, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
ATGAATAGAGCCTCCACCCCCAGCAGGGGGTTCCTGGGCCCGCCCAAGCACTGGGCTAAAACGTGGAAACTGGGCATTGACAAAGTACAGCGGGATGTGGGCAATTCGGCCTGTGGACCAGCCCTGCAGAGAAGGGAAAGAAAAGGATCAGAGTCTGGGCCCAAAGAAGGGCCACCTGGCAGAGCCATACAGCAGCCAAGGCCCTCAGCTTCTCCATCCAACTCCTGGAAGCCCCAGCAGCCTGGCGCACTCACCACACTGAGCAGGGCCCCTTTGTTGAAGGAAGGATGGAAAGTGATGAGCTGGGGCTGGGCTCCTGG...
ATGAATAGAGCCTCCACCCCCAGCAGGGGGTTCCTGGGCCCGCCCAAGCACTGGGCTAAAACGTGGAAACTGGGCATTGACAAAGTACAGCGGGATGTGGGCAATTCGGCCTGTGGACCAGCCCTGCAGAGAAGGGAAAGAAAAGGATCAGAGTCTGGGCCCAAAGAAGGGCCACCTGGCAGAGCCATACAGCAGCCAAGGCCCTCAGCTTCTCCATCCAACTCCTGGAAGCCCCAGCAGCCTGGCGCACTCACCACACTGAGCAGGGCCCCTTTGTTGAAGGAAGGATGGAAAGTGATGAGCTGGGGCTGGGCTCCTGG...
pathogenic
198,072
For chromosome 12, position 53309648, gene AAAS (aladin WD repeat nucleoporin): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
GCCTCCACCCCCAGCAGGGGGTTCCTGGGCCCGCCCAAGCACTGGGCTAAAACGTGGAAACTGGGCATTGACAAAGTACAGCGGGATGTGGGCAATTCGGCCTGTGGACCAGCCCTGCAGAGAAGGGAAAGAAAAGGATCAGAGTCTGGGCCCAAAGAAGGGCCACCTGGCAGAGCCATACAGCAGCCAAGGCCCTCAGCTTCTCCATCCAACTCCTGGAAGCCCCAGCAGCCTGGCGCACTCACCACACTGAGCAGGGCCCCTTTGTTGAAGGAAGGATGGAAAGTGATGAGCTGGGGCTGGGCTCCTGGCTCCCCCTG...
GCCTCCACCCCCAGCAGGGGGTTCCTGGGCCCGCCCAAGCACTGGGCTAAAACGTGGAAACTGGGCATTGACAAAGTACAGCGGGATGTGGGCAATTCGGCCTGTGGACCAGCCCTGCAGAGAAGGGAAAGAAAAGGATCAGAGTCTGGGCCCAAAGAAGGGCCACCTGGCAGAGCCATACAGCAGCCAAGGCCCTCAGCTTCTCCATCCAACTCCTGGAAGCCCCAGCAGCCTGGCGCACTCACCACACTGAGCAGGGCCCCTTTGTTGAAGGAAGGATGGAAAGTGATGAGCTGGGGCTGGGCTCCTGGCTCCCCCTG...
pathogenic
198,073
Clinical classification of chromosome 12, position 53320604, gene AAAS (aladin WD repeat nucleoporin): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
TAATTAATATGAACAAGGTAATCTAAGTAGAAAGTAGCAGTCAGGATTCAACCATCTATCTACCCCAGAACCTATACTCAAACCACTTTTTCCTGAATGAGTAATATGATCATTCCTTAAAGTGAACCATCCAGAGAAGCAGATTTGGAGAGAGAAATAAAGAGACTGGATTTGAGCATGCTGAATATATGAAGTCTGCGAAATATTCAAGCAGGATAATTTGGCAAACACGTGAACACCAGGTCTGATGCATCAACTGGAAATCTAGCCCCAAGAACACCAACATTTAAGGGACATCAGGAAGAGGAGCCACCAAAAAC...
TAATTAATATGAACAAGGTAATCTAAGTAGAAAGTAGCAGTCAGGATTCAACCATCTATCTACCCCAGAACCTATACTCAAACCACTTTTTCCTGAATGAGTAATATGATCATTCCTTAAAGTGAACCATCCAGAGAAGCAGATTTGGAGAGAGAAATAAAGAGACTGGATTTGAGCATGCTGAATATATGAAGTCTGCGAAATATTCAAGCAGGATAATTTGGCAAACACGTGAACACCAGGTCTGATGCATCAACTGGAAATCTAGCCCCAAGAACACCAACATTTAAGGGACATCAGGAAGAGGAGCCACCAAAAAC...
pathogenic
198,092
Variant in AAAS (aladin WD repeat nucleoporin), chromosome 12, position 53321407—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Glucocorticoid_deficiency_with_achalasia']
TTTGTACTTTTCTTGTAGAGAAAAGAACATGGTTTCGCCATGTTCCCCAGGCTAGTCTCAAACTACTAAGCTCAAGCAATCTGCTGGCCTCAGCCTACCAAAGCGCTGGGATTATAGGCGTGAGTCACTGTGCCTGGCATAAATAACCCTTAAAGGAATTAATATGTGCCATTAATAGGTCCAGGTGCAGTAGCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCCTGAGGTCAGGAGGCCAGACCACCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAATACAAAAAGTTAGCTGGGCGTGGTGGCACATGC...
TTTGTACTTTTCTTGTAGAGAAAAGAACATGGTTTCGCCATGTTCCCCAGGCTAGTCTCAAACTACTAAGCTCAAGCAATCTGCTGGCCTCAGCCTACCAAAGCGCTGGGATTATAGGCGTGAGTCACTGTGCCTGGCATAAATAACCCTTAAAGGAATTAATATGTGCCATTAATAGGTCCAGGTGCAGTAGCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCCTGAGGTCAGGAGGCCAGACCACCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAATACAAAAAGTTAGCTGGGCGTGGTGGCACATGC...
pathogenic
198,097
Clinical impact (benign or pathogenic) of the variant at chromosome 12, location 53335707, gene SP7 (Sp7 transcription factor): what disease(s) if pathogenic?
benign
ATTTCTTCCCCTTCCCTGTTCCCCTGAATCTCACTTGGCCGAGGTGAGCCCCCCATCAAGCAGCAGCTGCTTCCCACTGCCAGAGAGCCCACCCATACAAGGTGGAGGGCTTCCTGGGGAGGTGGGGAGGAAGTTGAGGGCCCAGGTACTCAAAAACTAGGTGCAAGTGGTCGAGGGACAGGAGGGACTGGTGTGCCTTCGTGTTGCAGGCATCTCCAGCTCACAGGAGTGAGGGGACATGAAAGTCTAGCTTCCACAACACTCTCCTTTCGCCATGCACTATCCCAATCCCATGTCTTTCCAGCAGGCCTCTGGGCCAG...
ATTTCTTCCCCTTCCCTGTTCCCCTGAATCTCACTTGGCCGAGGTGAGCCCCCCATCAAGCAGCAGCTGCTTCCCACTGCCAGAGAGCCCACCCATACAAGGTGGAGGGCTTCCTGGGGAGGTGGGGAGGAAGTTGAGGGCCCAGGTACTCAAAAACTAGGTGCAAGTGGTCGAGGGACAGGAGGGACTGGTGTGCCTTCGTGTTGCAGGCATCTCCAGCTCACAGGAGTGAGGGGACATGAAAGTCTAGCTTCCACAACACTCTCCTTTCGCCATGCACTATCCCAATCCCATGTCTTTCCAGCAGGCCTCTGGGCCAG...
benign
198,111
Benign or pathogenic: chromosome 12, position 54283202, gene HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) variant? Disease(s) if pathogenic?
benign
AGCCTTTGTTGCGCGTGCGTCGGAAGGCGACTAGGGACGCATGCGCTTGCGATTTCCTAGCACTCCCAACTCCAGCATACGGCCTCCCTTGATAGGCAGAAGCACGTGTCTTGTTGCGACCTGAACGAACAATAAGTGCTAGGTACACAGTTGGTGTCTAGTTTTTCTTTTCCTCGATGGAAATTGTTTCGTGTTGTAGCCCATTTAACACTTCCCCCTCCCCCCACTCTAGTCTCCTAAAGAGCCCGAACAGCTGAGGAAGCTCTTCATTGGAGGGTTGAGCTTTGAAACAACTGATGAGAGCCTGAGGAGCCATTTTG...
AGCCTTTGTTGCGCGTGCGTCGGAAGGCGACTAGGGACGCATGCGCTTGCGATTTCCTAGCACTCCCAACTCCAGCATACGGCCTCCCTTGATAGGCAGAAGCACGTGTCTTGTTGCGACCTGAACGAACAATAAGTGCTAGGTACACAGTTGGTGTCTAGTTTTTCTTTTCCTCGATGGAAATTGTTTCGTGTTGTAGCCCATTTAACACTTCCCCCTCCCCCCACTCTAGTCTCCTAAAGAGCCCGAACAGCTGAGGAAGCTCTTCATTGGAGGGTTGAGCTTTGAAACAACTGATGAGAGCCTGAGGAGCCATTTTG...
benign
198,152
Determine whether the variant at chromosome 12, position 55721251, in gene RDH5 is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Pigmentary_retinal_dystrophy']
AACTTCAACCAGGCACTCAAGGTGGGCCATACTCCCTACCTCACCACCCCAATCCTGGGCCCCCATTGGCTGCCTCCAGTCAGGTTACCTCAGGTTTAGGTTAAGGAGGAAGTAGGGTGGTCCCAGAAACCCCATCTATAGCCCCAGTGTCAGAAAAGGTAGAGAAAGAAAGAAAAGCAGTTGGTGGGTCCAAGTAAAGCCTTTTCCAGGAGATGAATAAAACGTATTCCCCAGACTGGAAGCCATACTCTACCCATTCTGATTCCTGGGCTCCCACCTCCTCTCCCCCTTCCCAGGAAATTGGGGATGTGGAGAACTGG...
AACTTCAACCAGGCACTCAAGGTGGGCCATACTCCCTACCTCACCACCCCAATCCTGGGCCCCCATTGGCTGCCTCCAGTCAGGTTACCTCAGGTTTAGGTTAAGGAGGAAGTAGGGTGGTCCCAGAAACCCCATCTATAGCCCCAGTGTCAGAAAAGGTAGAGAAAGAAAGAAAAGCAGTTGGTGGGTCCAAGTAAAGCCTTTTCCAGGAGATGAATAAAACGTATTCCCCAGACTGGAAGCCATACTCTACCCATTCTGATTCCTGGGCTCCCACCTCCTCTCCCCCTTCCCAGGAAATTGGGGATGTGGAGAACTGG...
pathogenic
198,299
Variant at chromosome position 55723947, chromosome 12, gene CD63: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Retinal_dystrophy']
GCTACTGTGTCTCCAAATTTGGCCTGGAGGCCTTCTCTGACAGCCTGAGGTGAGGGGTACAGGGCTCTGGGTTCCAGGACTAACAGCAGCCCACTCAACAAACGTGGGCCAGCAGAGGTGGTTAAGATACAGCACATTGGAATAGTTAAGAAGAGACAGTTTAGGGCTAGACTTCATGGGTTCAATGAAGTCTACCCTTATGTAAGCTTTGTGACCATAAGTAGATTACTTCTCTTTACCCATTTTTAACGTGTTTGTTTTTTGTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGGCTGGAGTGCAGTGGCGCGATCTT...
GCTACTGTGTCTCCAAATTTGGCCTGGAGGCCTTCTCTGACAGCCTGAGGTGAGGGGTACAGGGCTCTGGGTTCCAGGACTAACAGCAGCCCACTCAACAAACGTGGGCCAGCAGAGGTGGTTAAGATACAGCACATTGGAATAGTTAAGAAGAGACAGTTTAGGGCTAGACTTCATGGGTTCAATGAAGTCTACCCTTATGTAAGCTTTGTGACCATAAGTAGATTACTTCTCTTTACCCATTTTTAACGTGTTTGTTTTTTGTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGGCTGGAGTGCAGTGGCGCGATCTT...
pathogenic
198,322
The genetic variant at chromosome 12, position 55724401, affecting gene CD63: benign or pathogenic? Disease name(s) if pathogenic?
pathogenic
TTGGCCAGGTTGGTCTCAAACTCCTGACCTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTTGCCTCTCGTCTTTAAACAATAAGGTTCAAAGTTCCGTGGGAGCACAAAGGAGACATGATGAGGACAACGGGAGTAGGGCCTGAGTTTTTTTTTGTTTTTTTTTTTTTAAGCGTTTTGCTCTTGTTGCCTAGGCTGGAGTGCAATGGCGAGATCTCAGCTCACTGCAACCCCTGCCTCTCAGGTTCATGTGATTCTCCTGCCTCAGCCTCCCGATTAGCTGGGC...
TTGGCCAGGTTGGTCTCAAACTCCTGACCTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTTGCCTCTCGTCTTTAAACAATAAGGTTCAAAGTTCCGTGGGAGCACAAAGGAGACATGATGAGGACAACGGGAGTAGGGCCTGAGTTTTTTTTTGTTTTTTTTTTTTTAAGCGTTTTGCTCTTGTTGCCTAGGCTGGAGTGCAATGGCGAGATCTCAGCTCACTGCAACCCCTGCCTCTCAGGTTCATGTGATTCTCCTGCCTCAGCCTCCCGATTAGCTGGGC...
pathogenic
198,325
A mutation at chromosome position 55724516 on chromosome 12 in gene CD63: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Fundus_albipunctatus,_autosomal_recessive']
ATAAGGTTCAAAGTTCCGTGGGAGCACAAAGGAGACATGATGAGGACAACGGGAGTAGGGCCTGAGTTTTTTTTTGTTTTTTTTTTTTTAAGCGTTTTGCTCTTGTTGCCTAGGCTGGAGTGCAATGGCGAGATCTCAGCTCACTGCAACCCCTGCCTCTCAGGTTCATGTGATTCTCCTGCCTCAGCCTCCCGATTAGCTGGGCTTACAGGCACGTGCCACCACTCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGAGTTATACCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCCACCCGAC...
ATAAGGTTCAAAGTTCCGTGGGAGCACAAAGGAGACATGATGAGGACAACGGGAGTAGGGCCTGAGTTTTTTTTTGTTTTTTTTTTTTTAAGCGTTTTGCTCTTGTTGCCTAGGCTGGAGTGCAATGGCGAGATCTCAGCTCACTGCAACCCCTGCCTCTCAGGTTCATGTGATTCTCCTGCCTCAGCCTCCCGATTAGCTGGGCTTACAGGCACGTGCCACCACTCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGAGTTATACCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCCACCCGAC...
pathogenic
198,327
Variant at chromosome 12, position 56002602, gene SUOX (sulfite oxidase): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Sulfite_oxidase_deficiency']
GCCGACTCTGGCCTTGGCCAGCCCAGAAAGGGGCTCCCACAGTGCAGCGGCGAGCTGAAGGGCTCCTCAAGTGCCGCCAAAGTGGGAGCCCAGGCAGAGGAGGCACCGAGAGTGAGCAAGGGCTGTGAGGACTGCCAGCACAATGTCACTTCTCACTAGGATTATAAGGGTGAGCCACCACACCCAGCTCTTTTATTACAGTATAATGTTATAATTTTTTTCTTTTTCTTTGTTTTTTTTTTGAGACGTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCG...
GCCGACTCTGGCCTTGGCCAGCCCAGAAAGGGGCTCCCACAGTGCAGCGGCGAGCTGAAGGGCTCCTCAAGTGCCGCCAAAGTGGGAGCCCAGGCAGAGGAGGCACCGAGAGTGAGCAAGGGCTGTGAGGACTGCCAGCACAATGTCACTTCTCACTAGGATTATAAGGGTGAGCCACCACACCCAGCTCTTTTATTACAGTATAATGTTATAATTTTTTTCTTTTTCTTTGTTTTTTTTTTGAGACGTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCG...
pathogenic
198,349
Clinical classification of chromosome 12, position 56002633, gene SUOX (sulfite oxidase): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['SUOX-related_disorder', 'Sulfite_oxidase_deficiency', 'Sulfocysteinuria']
GGCTCCCACAGTGCAGCGGCGAGCTGAAGGGCTCCTCAAGTGCCGCCAAAGTGGGAGCCCAGGCAGAGGAGGCACCGAGAGTGAGCAAGGGCTGTGAGGACTGCCAGCACAATGTCACTTCTCACTAGGATTATAAGGGTGAGCCACCACACCCAGCTCTTTTATTACAGTATAATGTTATAATTTTTTTCTTTTTCTTTGTTTTTTTTTTGAGACGTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCACGCCATTCTCCTGTCTCC...
GGCTCCCACAGTGCAGCGGCGAGCTGAAGGGCTCCTCAAGTGCCGCCAAAGTGGGAGCCCAGGCAGAGGAGGCACCGAGAGTGAGCAAGGGCTGTGAGGACTGCCAGCACAATGTCACTTCTCACTAGGATTATAAGGGTGAGCCACCACACCCAGCTCTTTTATTACAGTATAATGTTATAATTTTTTTCTTTTTCTTTGTTTTTTTTTTGAGACGTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCACGCCATTCTCCTGTCTCC...
pathogenic
198,351
Gene mutation in SUOX (sulfite oxidase) at chromosome 12, position 56003811—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Inborn_genetic_diseases', 'Sulfite_oxidase_deficiency']
TAGGCTGTCACTACTTTTTTTTCACTTTTTTATCCCTGTTTAAGTCAGTCTGACCCACAGTTGTCCTCTGCTGACTTCAGAAATAATAATCTGGCCAGTAGACATTTGGTTTCGGTCCTTTAGGCCCTTCGCCCCAGGCATCGTTCTCTATGGTGGACAAAGTTCAGAATGGAAGATGGGAGAAAGGTGATTCTGATTCTAGAAGCACCCATCCCTCCTACCCCATTCCCCACCCGCATTACCTGCCATCCTGTCAGCACAGTCTGTCTCTGAAGTGCTCCAAGTTTTCTCTAAGGGCCCATTTGGACTCCCACTCTCAA...
TAGGCTGTCACTACTTTTTTTTCACTTTTTTATCCCTGTTTAAGTCAGTCTGACCCACAGTTGTCCTCTGCTGACTTCAGAAATAATAATCTGGCCAGTAGACATTTGGTTTCGGTCCTTTAGGCCCTTCGCCCCAGGCATCGTTCTCTATGGTGGACAAAGTTCAGAATGGAAGATGGGAGAAAGGTGATTCTGATTCTAGAAGCACCCATCCCTCCTACCCCATTCCCCACCCGCATTACCTGCCATCCTGTCAGCACAGTCTGTCTCTGAAGTGCTCCAAGTTTTCTCTAAGGGCCCATTTGGACTCCCACTCTCAA...
pathogenic
198,353
The mutation in gene SUOX (sulfite oxidase) at chromosome 12, position 56003908—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Sulfite_oxidase_deficiency']
GTAGACATTTGGTTTCGGTCCTTTAGGCCCTTCGCCCCAGGCATCGTTCTCTATGGTGGACAAAGTTCAGAATGGAAGATGGGAGAAAGGTGATTCTGATTCTAGAAGCACCCATCCCTCCTACCCCATTCCCCACCCGCATTACCTGCCATCCTGTCAGCACAGTCTGTCTCTGAAGTGCTCCAAGTTTTCTCTAAGGGCCCATTTGGACTCCCACTCTCAAGACTCCTCACTTGCCCAGAAAGCTCCTTGCTGACCTTCTCTGTGTCTTCCTCTCACCCATTCCCTTAGGCCTCCCTAATATCCCCTCCCAGGGTCTC...
GTAGACATTTGGTTTCGGTCCTTTAGGCCCTTCGCCCCAGGCATCGTTCTCTATGGTGGACAAAGTTCAGAATGGAAGATGGGAGAAAGGTGATTCTGATTCTAGAAGCACCCATCCCTCCTACCCCATTCCCCACCCGCATTACCTGCCATCCTGTCAGCACAGTCTGTCTCTGAAGTGCTCCAAGTTTTCTCTAAGGGCCCATTTGGACTCCCACTCTCAAGACTCCTCACTTGCCCAGAAAGCTCCTTGCTGACCTTCTCTGTGTCTTCCTCTCACCCATTCCCTTAGGCCTCCCTAATATCCCCTCCCAGGGTCTC...
pathogenic
198,354
Is the genetic change at chromosome 12, position 56004230, within gene SUOX (sulfite oxidase) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Inborn_genetic_diseases', 'SUOX-related_disorder', 'Sulfocysteinuria']
TATCTTGATCCCAGAATCTTCCTTCTACAGGTCTGCTACAATGCTGCTGCTGCACAGAGCTGTGGTCCTCAGGCTCCAACAGGCCTGCAGGTAGGCCAGCCCATCCCAGGACTTGCCTCCTAGCCCCTATCTGCCACCCTTAGTGTCTTTTACAATGTCATACCTTGCAAATAAGACAGTTGAGAGAGTGTGTCCAGGGAGGACAGAGAAAGCCAGATCCCACTTTTCCCACCTATCCCTGGAGAAACTAAGTTCCAACTTAAGGAACCAATGGCCAACCAGGGAGAAAGAAGTAGACCCCAAGCCTTCACTAGCCCTTT...
TATCTTGATCCCAGAATCTTCCTTCTACAGGTCTGCTACAATGCTGCTGCTGCACAGAGCTGTGGTCCTCAGGCTCCAACAGGCCTGCAGGTAGGCCAGCCCATCCCAGGACTTGCCTCCTAGCCCCTATCTGCCACCCTTAGTGTCTTTTACAATGTCATACCTTGCAAATAAGACAGTTGAGAGAGTGTGTCCAGGGAGGACAGAGAAAGCCAGATCCCACTTTTCCCACCTATCCCTGGAGAAACTAAGTTCCAACTTAAGGAACCAATGGCCAACCAGGGAGAAAGAAGTAGACCCCAAGCCTTCACTAGCCCTTT...
pathogenic
198,358
Variant in SUOX (sulfite oxidase), chromosome 12, position 56004699—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Sulfite_oxidase_deficiency']
GGGATGGAGAGTCATGGGGACCCTATTAGGTCTCGGTGCAGTGTTGGCCTATCAGGACCATCGGTGTAGGGTAAGTAGGGAAAGTGCTTCATTGTCAGAACAGACTGGGTGCAGTGGCTCACGCCTGTTATCCCAGCACTATAGGAGGCCAAGGTGGGTGGGTCACTTGAGGTTAGGAGTTTGAGACCAGCCTGGGCAACATGGCAAAACCCCATCTCTAGTAAAAATTAGCCAGGTGTGGTGGTACATACCTGTAATCTCAGCTACTTGAGAGGCTGAGACACAAGAATCACTTAAACCCAGGAGGCTAAGTCTGCAGT...
GGGATGGAGAGTCATGGGGACCCTATTAGGTCTCGGTGCAGTGTTGGCCTATCAGGACCATCGGTGTAGGGTAAGTAGGGAAAGTGCTTCATTGTCAGAACAGACTGGGTGCAGTGGCTCACGCCTGTTATCCCAGCACTATAGGAGGCCAAGGTGGGTGGGTCACTTGAGGTTAGGAGTTTGAGACCAGCCTGGGCAACATGGCAAAACCCCATCTCTAGTAAAAATTAGCCAGGTGTGGTGGTACATACCTGTAATCTCAGCTACTTGAGAGGCTGAGACACAAGAATCACTTAAACCCAGGAGGCTAAGTCTGCAGT...
pathogenic
198,367
Clinically, how would you classify the variant at chromosome 12, position 56042426, gene RPS26 (ribosomal protein S26): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Diamond-Blackfan_anemia', 'Diamond-Blackfan_anemia_10']
CTGTACCATCCTGGGTCTGAATGCTAGGAGGTCCCCTTGCCACCCTAGTGTCTTCAACTTTGGAGACAACTGGGTGGTTGGCTGTGGACAGCCATTCCTGCCAGGCTGAAGCTTGCTTGCTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTATTGCCCAGACTGTAGCACAGTAGCCCAATCTCAGCTCACTGCAACTTCTGCCTCCCGGGTGCAAGCAATTCTCCTGTCTCAGTCTCCCGAGTAGCTGGGATTACAGGTGTGCGCCACCAGGCCTAATTTTTATATTTTTAGTAGAGGTGGGGTGTCACTATG...
CTGTACCATCCTGGGTCTGAATGCTAGGAGGTCCCCTTGCCACCCTAGTGTCTTCAACTTTGGAGACAACTGGGTGGTTGGCTGTGGACAGCCATTCCTGCCAGGCTGAAGCTTGCTTGCTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTATTGCCCAGACTGTAGCACAGTAGCCCAATCTCAGCTCACTGCAACTTCTGCCTCCCGGGTGCAAGCAATTCTCCTGTCTCAGTCTCCCGAGTAGCTGGGATTACAGGTGTGCGCCACCAGGCCTAATTTTTATATTTTTAGTAGAGGTGGGGTGTCACTATG...
pathogenic
198,389
Is the genetic mutation found on chromosome 12 at position 56042490, within the gene RPS26 (ribosomal protein S26), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Diamond-Blackfan_anemia', 'Diamond-Blackfan_anemia_10']
GACAACTGGGTGGTTGGCTGTGGACAGCCATTCCTGCCAGGCTGAAGCTTGCTTGCTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTATTGCCCAGACTGTAGCACAGTAGCCCAATCTCAGCTCACTGCAACTTCTGCCTCCCGGGTGCAAGCAATTCTCCTGTCTCAGTCTCCCGAGTAGCTGGGATTACAGGTGTGCGCCACCAGGCCTAATTTTTATATTTTTAGTAGAGGTGGGGTGTCACTATGTTGACTAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGT...
GACAACTGGGTGGTTGGCTGTGGACAGCCATTCCTGCCAGGCTGAAGCTTGCTTGCTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTATTGCCCAGACTGTAGCACAGTAGCCCAATCTCAGCTCACTGCAACTTCTGCCTCCCGGGTGCAAGCAATTCTCCTGTCTCAGTCTCCCGAGTAGCTGGGATTACAGGTGTGCGCCACCAGGCCTAATTTTTATATTTTTAGTAGAGGTGGGGTGTCACTATGTTGACTAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGT...
pathogenic
198,392
Is the genetic mutation found on chromosome 12 at position 56043400, within the gene RPS26 (ribosomal protein S26), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Diamond-Blackfan_anemia_10']
ACAGGCGCCCACCACCAGGCCGGGCTAAATTCTTCAATCTTTAAAGTGAGGATAATAATAGTAGCTACCTATAGGCTTGCTCAAAGTTAAATGAGTTAATATTTATAAAGACGCTTACCACAGGGCCAGGCACTGTGCCAGAGATAAAAAGATGAATGAGAAATAGCCCCAGCCTCAATGCACTTCATTGTGGGATTTTCTCCATATTGGAAGGAGGGATTCACAAAATGCTTGTTTCCTCTCAGGCCTTCCTCTTCGTAATCCTACACCTACCTAGTAGAAGGACTGTCAGAGAAATGAGCCCAGGGCGTCCCCCGGTG...
ACAGGCGCCCACCACCAGGCCGGGCTAAATTCTTCAATCTTTAAAGTGAGGATAATAATAGTAGCTACCTATAGGCTTGCTCAAAGTTAAATGAGTTAATATTTATAAAGACGCTTACCACAGGGCCAGGCACTGTGCCAGAGATAAAAAGATGAATGAGAAATAGCCCCAGCCTCAATGCACTTCATTGTGGGATTTTCTCCATATTGGAAGGAGGGATTCACAAAATGCTTGTTTCCTCTCAGGCCTTCCTCTTCGTAATCCTACACCTACCTAGTAGAAGGACTGTCAGAGAAATGAGCCCAGGGCGTCCCCCGGTG...
pathogenic
198,399
Does the variant impacting SMARCC2 (SWI/SNF related BAF chromatin remodeling complex subunit C2) on chromosome 12, position 56185102, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Neurodevelopmental_delay']
GGTCTCAAACTCCTGGGCTCAAGCAATCTGCCCACCTCAGCCTCCCCAAGTGCTGGGATTATAGGCATTAGCCACTGCACCCAGCCTACGTGCTATTTTTTGTTTTGTTTTGTTTTGTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTAGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGCTGCCCCGGTTCAAGCGATTATCCTGCTTCTCAGCCTCCTAAGTAGCTAAAACTACAGGCGTGTGCCACCACGCCCTGCTAATTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCAGCATGTTG...
GGTCTCAAACTCCTGGGCTCAAGCAATCTGCCCACCTCAGCCTCCCCAAGTGCTGGGATTATAGGCATTAGCCACTGCACCCAGCCTACGTGCTATTTTTTGTTTTGTTTTGTTTTGTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTAGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGCTGCCCCGGTTCAAGCGATTATCCTGCTTCTCAGCCTCCTAAGTAGCTAAAACTACAGGCGTGTGCCACCACGCCCTGCTAATTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCAGCATGTTG...
pathogenic
198,457
Variant chromosome 12, position 56451131, gene MIP (major intrinsic protein of lens fiber): benign or pathogenic? Disease(s)?
benign
CGGAGCAGCGTAGGGCTAAGCCCGCGTCCGGTGAGACCCGGGAACGCGGCGCGGGAGACTAAGGAGCAGAGTACAGAATTGCGCGTGCGCGCCTGCAGCACGAGCCCCGCCCCCTGGCTCTAAACCGGGTGGCGGGAAAAGGGACTCAGCGTTTCCCGAGAATGCCCCCATAGCTTCGAAAGGATCCCCGTGTCCGCTTAGCGCCCTCTCGCCACACACTCACTCACCCGCTCCCTGCGGGTCCTCAGAAGCCCGGAGGAGCCACCGGCCCTCTGGCGCGGGGCCGCAGCCTTTCCGCCACCAGGCTCAGCTGGACCGGT...
CGGAGCAGCGTAGGGCTAAGCCCGCGTCCGGTGAGACCCGGGAACGCGGCGCGGGAGACTAAGGAGCAGAGTACAGAATTGCGCGTGCGCGCCTGCAGCACGAGCCCCGCCCCCTGGCTCTAAACCGGGTGGCGGGAAAAGGGACTCAGCGTTTCCCGAGAATGCCCCCATAGCTTCGAAAGGATCCCCGTGTCCGCTTAGCGCCCTCTCGCCACACACTCACTCACCCGCTCCCTGCGGGTCCTCAGAAGCCCGGAGGAGCCACCGGCCCTCTGGCGCGGGGCCGCAGCCTTTCCGCCACCAGGCTCAGCTGGACCGGT...
benign
198,507
Does the variant on chromosome 12 at location 56451433 affecting gene MIP (major intrinsic protein of lens fiber) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Cataract_15_multiple_types', 'Inborn_genetic_diseases', 'MIP-related_disorder']
AGGCTCAGCTGGACCGGTCCCCGCCTGCGCGAAGAGCGAGGCGGGGCGAGCCGGGCTGGTCCACGTGACTCCGAGCGAACTGGGGCGGAGATTGGTGAAGAAGGAAGGAAAAGGGAAGCGAGTGCAGGGACTGTTTTATGTGAGGTCGATCTAAAAATCACAGCGCTATGAATTTTCTGCTGAATTATAGTAGAATCAAAGTCCGATTAGAGGTGAATTTACAAACATTCTTCCCCTTCTTCTAGTCAAGCGGACTATTCCAAGTCTTAAATAGTTAGTTAGAAAAGTTAGGTTTTATTTGGGAGGAAGTAAAGAGCTGA...
AGGCTCAGCTGGACCGGTCCCCGCCTGCGCGAAGAGCGAGGCGGGGCGAGCCGGGCTGGTCCACGTGACTCCGAGCGAACTGGGGCGGAGATTGGTGAAGAAGGAAGGAAAAGGGAAGCGAGTGCAGGGACTGTTTTATGTGAGGTCGATCTAAAAATCACAGCGCTATGAATTTTCTGCTGAATTATAGTAGAATCAAAGTCCGATTAGAGGTGAATTTACAAACATTCTTCCCCTTCTTCTAGTCAAGCGGACTATTCCAAGTCTTAAATAGTTAGTTAGAAAAGTTAGGTTTTATTTGGGAGGAAGTAAAGAGCTGA...
pathogenic
198,509
A genetic variant at chromosome 12, position 56930421, affecting gene SDR9C7 (short chain dehydrogenase/reductase family 9C member 7)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Ichthyosis,_congenital,_autosomal_recessive_13', 'Lamellar_ichthyosis']
CCTTCACCATAGTCTGAATTGGGACCGCAACTTCCTGCTCCATTCTTCTTTCACAACCCTGTTTCTCCTCTGTAGCACTTATCCACATCTACCATAAACACATGTGTTTTGATTTATGTTTGTCTCCCCTACTGGGCCATAAGCTACAGGCAGTGAAGGGCAGGCATACTGCTGTGTCCGCTCCAGCTCTCCAGCCCCACACAGGCTTGGGACATGGCAGCCTTGCATGCTTTGTATTACTGATTCAAAACAAAAACAAAAAACAAAAATGCAATAAAGTGTGTATGTATTAAGTGAAAAAAATGGCTGACTTGGCTTTG...
CCTTCACCATAGTCTGAATTGGGACCGCAACTTCCTGCTCCATTCTTCTTTCACAACCCTGTTTCTCCTCTGTAGCACTTATCCACATCTACCATAAACACATGTGTTTTGATTTATGTTTGTCTCCCCTACTGGGCCATAAGCTACAGGCAGTGAAGGGCAGGCATACTGCTGTGTCCGCTCCAGCTCTCCAGCCCCACACAGGCTTGGGACATGGCAGCCTTGCATGCTTTGTATTACTGATTCAAAACAAAAACAAAAAACAAAAATGCAATAAAGTGTGTATGTATTAAGTGAAAAAAATGGCTGACTTGGCTTTG...
pathogenic
198,537
Gene STAC3 (SH3 and cysteine rich domain 3) variant at chromosome position 57244355 on chromosome 12: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Bailey-Bloch_congenital_myopathy']
GGGGGTCTTCTTTAATGACTCCGCCCCCACCCCCTCAGGCATCCGGGACCGTCAAGGGCAAAGGGAACAGAAAACTGAACCCGGTTCTGCAGAGTCTTCTTGTGTGCTTCCCTACCCCCATCACACCTCAGCCTTCTGGAAGGGGGGCGCGCCCGTCCCAGGCCTCCTCTTCCCCAGCCCAGCTGAGCCTCTGCCCTCCCCCCGCCAGCAGCAGATGGTGCCCGGGCTCCCGCTGCCAACCTTGCTAGGCGGTGCCAACCTCGGTCCTGGCAGACAACGGGCAGACGAGAAGAGGAGCTCCTGGCTGGCCAAGCCGACCC...
GGGGGTCTTCTTTAATGACTCCGCCCCCACCCCCTCAGGCATCCGGGACCGTCAAGGGCAAAGGGAACAGAAAACTGAACCCGGTTCTGCAGAGTCTTCTTGTGTGCTTCCCTACCCCCATCACACCTCAGCCTTCTGGAAGGGGGGCGCGCCCGTCCCAGGCCTCCTCTTCCCCAGCCCAGCTGAGCCTCTGCCCTCCCCCCGCCAGCAGCAGATGGTGCCCGGGCTCCCGCTGCCAACCTTGCTAGGCGGTGCCAACCTCGGTCCTGGCAGACAACGGGCAGACGAGAAGAGGAGCTCCTGGCTGGCCAAGCCGACCC...
pathogenic
198,697
Does the variant impacting STAC3 (SH3 and cysteine rich domain 3) on chromosome 12, position 57249535, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
ACAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCTCCGAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTGTGTTTTTAGTAGAGACGGGGTTTCACCGTGGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAACGTGAGCCACCGCGCCCGGCCTGGGTTGCCAAATTATGAACCTGCCCAGGGTGCCTGCAGCCTTTGGGTCTTGCCCCGAGTCTGATATGACTCTGTAGTAAGGAT...
ACAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCTCCGAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTGTGTTTTTAGTAGAGACGGGGTTTCACCGTGGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAACGTGAGCCACCGCGCCCGGCCTGGGTTGCCAAATTATGAACCTGCCCAGGGTGCCTGCAGCCTTTGGGTCTTGCCCCGAGTCTGATATGACTCTGTAGTAAGGAT...
benign
198,707
Does the genetic variant at chromosome 12, position 57564440, impacting gene KIF5A (kinesin family member 5A), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
TTTTAGTAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTCGAACTCCTCACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCCGACCCACAGTTCTTCTTTAATTAAAGCTTGTTCTGTTCTTAAAGGGAGACCCACATATCTGATTTCATATATTCCTTTCACAAAGAGAGAGAGCTTGTGTTAATGTTTCCACAGAGGCTCTCAGTGTAGACTGAATTTCATTTACATGGTAGGGAACATGCTATAAATATATGTCACTAACTTTGCATCTTTCACTTAGT...
TTTTAGTAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTCGAACTCCTCACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCCGACCCACAGTTCTTCTTTAATTAAAGCTTGTTCTGTTCTTAAAGGGAGACCCACATATCTGATTTCATATATTCCTTTCACAAAGAGAGAGAGCTTGTGTTAATGTTTCCACAGAGGCTCTCAGTGTAGACTGAATTTCATTTACATGGTAGGGAACATGCTATAAATATATGTCACTAACTTTGCATCTTTCACTTAGT...
benign
198,814
Is the variant located on chromosome 12 at position 57631319, gene B4GALNT1 (beta-1,4-N-acetyl-galactosaminyltransferase 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Hereditary_spastic_paraplegia_26', 'Inborn_genetic_diseases', 'Spastic_paraplegia']
GTTCTTACCTTTATGGAACTTACATTCTAATGGGTAGGAGAAAAAACAACAAAGAAAATTTTAAGTAAAAGCTAATCTTTATTGAGCACTTACTATGTGCCAGACCCGTTAAAAAATTACCTTAAATATATGCACTCATTTTATCCCCATGATAGCCCTATTAAGTAGATTCCTACAACAGAAAAAAAAGCTGAGACACAGAAAAGTAACTTGCCACATTTACACAACTATTAAGCAACAAAACTGATAGCAACCTAGTCAGTCTGGTGCCAGGCTAAGTAAATTAAAAAATTCAGATACTGGTAAGTATTGAGTGGAAA...
GTTCTTACCTTTATGGAACTTACATTCTAATGGGTAGGAGAAAAAACAACAAAGAAAATTTTAAGTAAAAGCTAATCTTTATTGAGCACTTACTATGTGCCAGACCCGTTAAAAAATTACCTTAAATATATGCACTCATTTTATCCCCATGATAGCCCTATTAAGTAGATTCCTACAACAGAAAAAAAAGCTGAGACACAGAAAAGTAACTTGCCACATTTACACAACTATTAAGCAACAAAACTGATAGCAACCTAGTCAGTCTGGTGCCAGGCTAAGTAAATTAAAAAATTCAGATACTGGTAAGTATTGAGTGGAAA...
pathogenic
198,939
Regarding the variant found on chromosome 12 at position 57631993 in gene B4GALNT1 (beta-1,4-N-acetyl-galactosaminyltransferase 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Spastic_paraplegia']
TCCCTCTGGCCTGCTCCAGCCCCAGATGAACAAAGGCCCCCTTTCTCCCTCTGGCCCTGCTGGTCCAGTTGAAGCACCCATTGTGTGGCTGGACAGCTCTGGCCATAGCCCAGATGCCTCCCATGCCCTCTGCCATTTGCCCACTCCAGCCTTTCTGGTTCTTCTCTGTTTGCCCAGCCTGCCCGTCTCTCCACCCAGGCCTTGCACCTGTGTCTGCTGTGTTGGTCTGGTAGCTTCGGCTGCTGTAAGTGACCAGTTGTAGTTGCCTGTTGAGTTGGTCCAGCCCTGGGCTGACAAGGGTGAGATCTGCCTGACCCTCT...
TCCCTCTGGCCTGCTCCAGCCCCAGATGAACAAAGGCCCCCTTTCTCCCTCTGGCCCTGCTGGTCCAGTTGAAGCACCCATTGTGTGGCTGGACAGCTCTGGCCATAGCCCAGATGCCTCCCATGCCCTCTGCCATTTGCCCACTCCAGCCTTTCTGGTTCTTCTCTGTTTGCCCAGCCTGCCCGTCTCTCCACCCAGGCCTTGCACCTGTGTCTGCTGTGTTGGTCTGGTAGCTTCGGCTGCTGTAAGTGACCAGTTGTAGTTGCCTGTTGAGTTGGTCCAGCCCTGGGCTGACAAGGGTGAGATCTGCCTGACCCTCT...
pathogenic
198,942
Is the genetic variant on chromosome 12, position 57748623, gene CDK4, benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
CCCATATCTTTCAGACAGATGTCATCAATGCTTCTTGGTGGGTCATGAGCAACAAGACTCGGGATGAACTGGAAAGAAGTTTTGATTGTTGTGGCTTATTCAACCTCACAACCCTGTATCAACAAGATTATGATTTCTGCACTGCAGTGAGTGTGTTGGGGGTGGTGCAGCAGCCAGGGGAGGTAGGAAACTGGGTAAGGACAATGCCCAAGTTGGCAAATTTAGTTTGAATGTCATTGTTTCTCTCTCTACAAGCCCTCTTGTATTGGGGCTGTGTTGGTGGGAGGTGGGGGTGGATAGAGGCTGGGGAATTAGCCAAG...
CCCATATCTTTCAGACAGATGTCATCAATGCTTCTTGGTGGGTCATGAGCAACAAGACTCGGGATGAACTGGAAAGAAGTTTTGATTGTTGTGGCTTATTCAACCTCACAACCCTGTATCAACAAGATTATGATTTCTGCACTGCAGTGAGTGTGTTGGGGGTGGTGCAGCAGCCAGGGGAGGTAGGAAACTGGGTAAGGACAATGCCCAAGTTGGCAAATTTAGTTTGAATGTCATTGTTTCTCTCTCTACAAGCCCTCTTGTATTGGGGCTGTGTTGGTGGGAGGTGGGGGTGGATAGAGGCTGGGGAATTAGCCAAG...
benign
198,973
Is the genetic variant on chromosome 12, position 57749141, gene CDK4, benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
ATCCTAGGGGGTGTTGGACTCTTCTTTAGCTTTACAGAGGTAACATTCTCCAGTTCCCTCACACACATCCTTTTTGAGACTGAGAATTAATTGATACTTATCTCTCTCCCTTTGTTCCTACAGATCCTTGGTGTTTGGCTAGCAATGAGATTTCGGAATCAGAAGGATCCTAGAGCCAACCCCAGTGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCT...
ATCCTAGGGGGTGTTGGACTCTTCTTTAGCTTTACAGAGGTAACATTCTCCAGTTCCCTCACACACATCCTTTTTGAGACTGAGAATTAATTGATACTTATCTCTCTCCCTTTGTTCCTACAGATCCTTGGTGTTTGGCTAGCAATGAGATTTCGGAATCAGAAGGATCCTAGAGCCAACCCCAGTGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCT...
benign
198,981
Gene CDK4 variant at chromosome position 57749321 on chromosome 12: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
CCCAGTGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCTCTAAAATTGATGGAATAGCAAGACTTTATGCCTTGACATATTTTAGTGGGAGCCAGACTATAAGGAATAAAAGGAAAAACTTTCTTCCTCTCTCTCCAAGAGGATATGGGAAGCTTCTGTGAGTGCATAGGATGGGGGCTGGAGTCATTCTTAGCTGTTTCCCTTCCTCTGTCCATATAC...
CCCAGTGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCTCTAAAATTGATGGAATAGCAAGACTTTATGCCTTGACATATTTTAGTGGGAGCCAGACTATAAGGAATAAAAGGAAAAACTTTCTTCCTCTCTCTCCAAGAGGATATGGGAAGCTTCTGTGAGTGCATAGGATGGGGGCTGGAGTCATTCTTAGCTGTTTCCCTTCCTCTGTCCATATAC...
benign
199,016
Variant at chromosome 12, position 57749326, gene CDK4: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
TGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCTCTAAAATTGATGGAATAGCAAGACTTTATGCCTTGACATATTTTAGTGGGAGCCAGACTATAAGGAATAAAAGGAAAAACTTTCTTCCTCTCTCTCCAAGAGGATATGGGAAGCTTCTGTGAGTGCATAGGATGGGGGCTGGAGTCATTCTTAGCTGTTTCCCTTCCTCTGTCCATATACTGGAT...
TGCCTTTCTATGAGACTTTGGATCCTTCTGACTTTTCTTCTGCTCTCTCTAAGCTTTCTCTTCCTCCCTTAGGGAATATCTAGGGTCTGTAACCGTTTTGGTTTGAGAAAAAGGAAAGGCCCCTTGTCACATCCTCTAAAATTGATGGAATAGCAAGACTTTATGCCTTGACATATTTTAGTGGGAGCCAGACTATAAGGAATAAAAGGAAAAACTTTCTTCCTCTCTCTCCAAGAGGATATGGGAAGCTTCTGTGAGTGCATAGGATGGGGGCTGGAGTCATTCTTAGCTGTTTCCCTTCCTCTGTCCATATACTGGAT...
benign
199,020