question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Regarding the variant at chromosome 2 and position 32224802, affecting gene NLRC4 (NLR family CARD domain containing 4): benign or pathogenic? If pathogenic, what are the associated illness(es)?
benign
ACTATTACAGGATGATTCTTCTTCCTCCATTGATCTCAACTAAATATGAATTAGGGTCATGCATGAAATCTGAACTGCCGTGTCCTGAGTTATGGTTAAGAGGTATGTGCTGCCACCCCATGCATGTCTTCCCCATCCCCATAGGATTTTAAAGTGTTCAGGTACCAAACACAGTTCTGTGTGAGGTTTTATGCCTACTTCCTCAACACCAATTCAGAGGCAACACCTGTGCATCTGTCCCACCAAAGGTGCTTTAATACCTACCTTCACTATTTGAGAAAGGACACTCACAGTTGCCTGTGGGTTATGAAAGAATTGGC...
ACTATTACAGGATGATTCTTCTTCCTCCATTGATCTCAACTAAATATGAATTAGGGTCATGCATGAAATCTGAACTGCCGTGTCCTGAGTTATGGTTAAGAGGTATGTGCTGCCACCCCATGCATGTCTTCCCCATCCCCATAGGATTTTAAAGTGTTCAGGTACCAAACACAGTTCTGTGTGAGGTTTTATGCCTACTTCCTCAACACCAATTCAGAGGCAACACCTGTGCATCTGTCCCACCAAAGGTGCTTTAATACCTACCTTCACTATTTGAGAAAGGACACTCACAGTTGCCTGTGGGTTATGAAAGAATTGGC...
benign
31,725
Evaluate if the mutation on chromosome 2 at position 32224810 in NLRC4 (NLR family CARD domain containing 4) is benign or pathogenic. Disease name(s) if pathogenic?
benign
AGGATGATTCTTCTTCCTCCATTGATCTCAACTAAATATGAATTAGGGTCATGCATGAAATCTGAACTGCCGTGTCCTGAGTTATGGTTAAGAGGTATGTGCTGCCACCCCATGCATGTCTTCCCCATCCCCATAGGATTTTAAAGTGTTCAGGTACCAAACACAGTTCTGTGTGAGGTTTTATGCCTACTTCCTCAACACCAATTCAGAGGCAACACCTGTGCATCTGTCCCACCAAAGGTGCTTTAATACCTACCTTCACTATTTGAGAAAGGACACTCACAGTTGCCTGTGGGTTATGAAAGAATTGGCCCTACGTC...
AGGATGATTCTTCTTCCTCCATTGATCTCAACTAAATATGAATTAGGGTCATGCATGAAATCTGAACTGCCGTGTCCTGAGTTATGGTTAAGAGGTATGTGCTGCCACCCCATGCATGTCTTCCCCATCCCCATAGGATTTTAAAGTGTTCAGGTACCAAACACAGTTCTGTGTGAGGTTTTATGCCTACTTCCTCAACACCAATTCAGAGGCAACACCTGTGCATCTGTCCCACCAAAGGTGCTTTAATACCTACCTTCACTATTTGAGAAAGGACACTCACAGTTGCCTGTGGGTTATGAAAGAATTGGCCCTACGTC...
benign
31,727
Mutation at chromosome 2, position 32236424, within NLRC4 (NLR family CARD domain containing 4): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
TGTCTAAAAAAAAAACAAAAAACAAAGAACAAAAACAGTTTAATAAATTGTACGTTACGTAAACTAAACACATTTTAGACAATCTGTAAGAGAAATGAAGGCAATCGAGGCTGTTTTCACAAGTCCTTGGCTTTAGTATGATAGCTTCCAAGTTGAACCTGATGAGCCTGACCTCCTTGTATTAATGTTTCCATACGCTGGATTGGAATAACTTGTGCAACCAGTGGGATATGTCAGAAGTGACCAGAAATGAGTGGGCTGCCATGTTGTGAGGACACTCACAGCCTGTGAAGAGGTCTAATGATGAGGAAGTGAGGCCT...
TGTCTAAAAAAAAAACAAAAAACAAAGAACAAAAACAGTTTAATAAATTGTACGTTACGTAAACTAAACACATTTTAGACAATCTGTAAGAGAAATGAAGGCAATCGAGGCTGTTTTCACAAGTCCTTGGCTTTAGTATGATAGCTTCCAAGTTGAACCTGATGAGCCTGACCTCCTTGTATTAATGTTTCCATACGCTGGATTGGAATAACTTGTGCAACCAGTGGGATATGTCAGAAGTGACCAGAAATGAGTGGGCTGCCATGTTGTGAGGACACTCACAGCCTGTGAAGAGGTCTAATGATGAGGAAGTGAGGCCT...
benign
31,736
Regarding the variant found on chromosome 2 at position 32241111 in gene NLRC4 (NLR family CARD domain containing 4): is it benign or pathogenic? If pathogenic, identify the disease(s).
benign
CTGAGGTCAGGAGTTCAAGACCAGCCTGTCCAACATGGCGGAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGCACACCTGTAATCTCAGCTACTTCGGAGGTTGAGGCATTAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAACATCTCACCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCCATCTCAAAGAAAAGAAAAGAAAAGAAATAAAATATATGATTCTAATAATATCAGTCTTGCAGAGCTTTCGGGAAGGTTGCAGATAATGTACGTTAACATATTTAAT...
CTGAGGTCAGGAGTTCAAGACCAGCCTGTCCAACATGGCGGAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGCACACCTGTAATCTCAGCTACTTCGGAGGTTGAGGCATTAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAACATCTCACCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCCATCTCAAAGAAAAGAAAAGAAAAGAAATAAAATATATGATTCTAATAATATCAGTCTTGCAGAGCTTTCGGGAAGGTTGCAGATAATGTACGTTAACATATTTAAT...
benign
31,738
Clinical classification of chromosome 2, position 32256724, gene NLRC4 (NLR family CARD domain containing 4): benign or pathogenic? Disease(s) if pathogenic?
benign
TGGCGCGATCTCAGCTCACCACAACCTCTGCCTGCCAGGTTCAAGCAATTCCCCTGCCTCGGCCTCCCAAGCAGCTGGGATTACAGGCATGCGCCACCACACCCAGCTAATTTTGTATTTTTAGTAGAGATGAGATTTCTCTATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCCGTCTCAGCTTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCGCACCTGGCCGCTCCTGGCTTTCAAACCTGTGTTGACTGATCAGAGAGGGAATGCACTCCTCTCAAAGACCCCAGAACCTCTCTGGCC...
TGGCGCGATCTCAGCTCACCACAACCTCTGCCTGCCAGGTTCAAGCAATTCCCCTGCCTCGGCCTCCCAAGCAGCTGGGATTACAGGCATGCGCCACCACACCCAGCTAATTTTGTATTTTTAGTAGAGATGAGATTTCTCTATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCCGTCTCAGCTTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCGCACCTGGCCGCTCCTGGCTTTCAAACCTGTGTTGACTGATCAGAGAGGGAATGCACTCCTCTCAAAGACCCCAGAACCTCTCTGGCC...
benign
31,762
Does the variant impacting EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) on chromosome 2, position 37114864, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
TTAACTACCTTCACAATGTTGTATAACCATCACCACTATCTATTTCCAGAACTTTTCATCACCCCAAACAGAAGCTATACCCATTAAACAAGAAGTTCCCATTCCTCCCTTCTTCCAGATAACCTCTGTTCCACTTTCTGTCTCTATGAATTTTCCTTAAAATAGCATTTAAATAATTAACTGCTTAACACGTAGTGATGAAGCAACTGCATATTCACACGGGGAAAATCAAGTTAGATTCCTTTCTCATACATAAACAAAAGTTAATTCAAATTGCAGTTAATTTTTATGTTAGTAAAACCAAAAAATATTTTCATAAT...
TTAACTACCTTCACAATGTTGTATAACCATCACCACTATCTATTTCCAGAACTTTTCATCACCCCAAACAGAAGCTATACCCATTAAACAAGAAGTTCCCATTCCTCCCTTCTTCCAGATAACCTCTGTTCCACTTTCTGTCTCTATGAATTTTCCTTAAAATAGCATTTAAATAATTAACTGCTTAACACGTAGTGATGAAGCAACTGCATATTCACACGGGGAAAATCAAGTTAGATTCCTTTCTCATACATAAACAAAAGTTAATTCAAATTGCAGTTAATTTTTATGTTAGTAAAACCAAAAAATATTTTCATAAT...
benign
31,829
Is the variant located on chromosome 2 at position 38070511, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
GTTCATGATTATTTTTGCAGCTACACATTTCTCAATCTAAAAAAATAGGCTACAGCAGCCCAAATTCACTGTCTCAGCCTTGGTGGGGCATAATATTTTGGAATGGCAAGTGCCAAAAAATTTAAATGTACTGGGCAAGCCTGCTTTGTGTAGTTGACTCTAATGCCTTTAAAAATACTGGCATGATTTTTTATATTCAAGAAGTACAGCTATGAAATTTTAAAATAAAATTACATGAAGTTTTTTAATATTCCAAACCACAAAACAGATCTGCTATGTTGTAGACTTTTTTAATAGCCTATTTGAGATTTAACTCTGCT...
GTTCATGATTATTTTTGCAGCTACACATTTCTCAATCTAAAAAAATAGGCTACAGCAGCCCAAATTCACTGTCTCAGCCTTGGTGGGGCATAATATTTTGGAATGGCAAGTGCCAAAAAATTTAAATGTACTGGGCAAGCCTGCTTTGTGTAGTTGACTCTAATGCCTTTAAAAATACTGGCATGATTTTTTATATTCAAGAAGTACAGCTATGAAATTTTAAAATAAAATTACATGAAGTTTTTTAATATTCCAAACCACAAAACAGATCTGCTATGTTGTAGACTTTTTTAATAGCCTATTTGAGATTTAACTCTGCT...
benign
31,873
Variant on chromosome 2, at position 38070812, affecting CYP1B1 (cytochrome P450 family 1 subfamily B member 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Anterior_segment_dysgenesis_6', 'Glaucoma_3,_primary_infantile,_B', 'Glaucoma_3A']
TTTGAGATTTAACTCTGCTACGCCAAACATCTTTCTTCTAAATGTCCATGCTTTGAATTTTGTGCTCCAAATTAATTAATTCAGAATGAGTGGGAAAATGTTTAACCATCTTTCCTTCTTTTCAGTGTTTCTCTCTTTTCTCTTACCATCCCCCCACCCCACACACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCA...
TTTGAGATTTAACTCTGCTACGCCAAACATCTTTCTTCTAAATGTCCATGCTTTGAATTTTGTGCTCCAAATTAATTAATTCAGAATGAGTGGGAAAATGTTTAACCATCTTTCCTTCTTTTCAGTGTTTCTCTCTTTTCTCTTACCATCCCCCCACCCCACACACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCA...
pathogenic
31,874
Classify the chromosome 2 variant at position 38070963 affecting gene CYP1B1 as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma', 'Primary_congenital_glaucoma']
CCCCACCCCACACACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTT...
CCCCACCCCACACACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTT...
pathogenic
31,876
Benign or pathogenic: chromosome 2, position 38070975, gene CYP1B1 variant? Disease(s) if pathogenic?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma']
CACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGG...
CACACATACACACAACTATCAAAAACTCCCTTTTTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGG...
pathogenic
31,877
Variant in CYP1B1, chromosome 2, position 38071008—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma']
TTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAA...
TTTAAAATTTTGGTACAAAGATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAA...
pathogenic
31,880
Clinically, how would you classify the variant at chromosome 2, position 38071028, gene CYP1B1: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Glaucoma_3A']
ATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTA...
ATTCCAAAAAGCTTAATAAAATGTAATAAGCACTTAGCACTTAGGACACTGTAGAACTTTCTTTGGAAGTTTAATTGCAATGAACTTTAAAACTTGAAACTTCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTA...
pathogenic
31,885
Does the chromosome 2 mutation at position 38071129 within gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma']
TCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCT...
TCAATTCACTTTTCTAAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCT...
pathogenic
31,889
Variant chromosome 2, position 38071144, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? Disease(s)?
pathogenic; ['Anterior_segment_dysgenesis', 'Anterior_segment_dysgenesis_6', 'CYP1B1-related_disorder', 'Congenital_glaucoma', 'Glaucoma_3A', 'Irido-corneo-trabecular_dysgenesis']
AAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGA...
AAATGTGAATGCATACATTTCATTTGAGCTTTATGCTTTCCCAGCTACCAAAGTAATTGCCATCTTAAAAAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGA...
pathogenic
31,890
A mutation at chromosome position 38071213 on chromosome 2 in gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma', 'Glaucoma_3A']
AAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAA...
AAACACAACTGACCTCATCTCCACTGTCTTTTCCAAACAGCTTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAA...
pathogenic
31,896
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 38071254, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Glaucoma_3,_primary_infantile,_B', 'Glaucoma_3A']
TTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAATTTAAGCATGCCATGAATTTGGAATTTTAATATATTAATTA...
TTCCAAGACTATCTTCTGATTCTGACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAATTTAAGCATGCCATGAATTTGGAATTTTAATATATTAATTA...
pathogenic
31,897
Variant chromosome 2, position 38071277, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? Disease(s)?
pathogenic; ['Anterior_segment_dysgenesis_6', 'CYP1B1-related_disorder', 'Congenital_glaucoma', 'Glaucoma_3A', 'Primary_congenital_glaucoma']
GACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAATTTAAGCATGCCATGAATTTGGAATTTTAATATATTAATTAGGTTATTTTCAAAACAAGATTCT...
GACTTTCCAAAAAGCAGGCATTAATGTTAACTTTCAAAAAATCATCTAGAAGAGAAACTTGGTCAGTTGTAATGGGAGTTCTGTCCCCAACTCTTGTCACCTCGTAAAAAGAACATCCAGGTAATTCATGGCATTTTCCATTATTCATTGGGCAGACACAGCTTAGATTTCTCTGCCTTCCACAGGAGAATGTTCAGATTTCCACTAACTTCAACTGGAACTCAATAATCAGAATGGCTTTAAAATTTAGTTAAAATTTAAGCATGCCATGAATTTGGAATTTTAATATATTAATTAGGTTATTTTCAAAACAAGATTCT...
pathogenic
31,899
Does the variant on chromosome 2 at location 38074400 affecting gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma', 'Primary_congenital_glaucoma']
GTCTCTAAGGTAAGTAAATACATAAAATTAAAATAAAAATTTTAAAAATGCAATCAAGGCCAATGACCAACATTAAAGTTCAATAAATGATTATATATAACTATACATTATCATAGCAAAATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAAC...
GTCTCTAAGGTAAGTAAATACATAAAATTAAAATAAAAATTTTAAAAATGCAATCAAGGCCAATGACCAACATTAAAGTTCAATAAATGATTATATATAACTATACATTATCATAGCAAAATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAAC...
pathogenic
31,903
Chromosome 2, position 38074417, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma', 'Primary_congenital_glaucoma']
ATACATAAAATTAAAATAAAAATTTTAAAAATGCAATCAAGGCCAATGACCAACATTAAAGTTCAATAAATGATTATATATAACTATACATTATCATAGCAAAATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACAT...
ATACATAAAATTAAAATAAAAATTTTAAAAATGCAATCAAGGCCAATGACCAACATTAAAGTTCAATAAATGATTATATATAACTATACATTATCATAGCAAAATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACAT...
pathogenic
31,905
Variant at chromosome 2, position 38074520, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Anterior_segment_dysgenesis_6', 'CYP1B1-related_disorder', 'Congenital_glaucoma', 'Congenital_ocular_coloboma', 'Glaucoma_3A']
ATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCC...
ATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCC...
pathogenic
31,907
Variant in CYP1B1 (cytochrome P450 family 1 subfamily B member 1), chromosome 2, position 38074520—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma']
ATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCC...
ATACTATATAGCCATCAAAAATTACCAAAATAAATATTAAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCC...
pathogenic
31,908
A mutation at chromosome position 38074558 on chromosome 2 in gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma', 'Glaucoma_3,_primary_infantile,_B', 'Glaucoma_3A']
AAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCCATCGACAATGTATAAATGAATGGGCATGACTGCGTCAA...
AAAAGATTAGAAATGTCCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCCATCGACAATGTATAAATGAATGGGCATGACTGCGTCAA...
pathogenic
31,910
Assess the variant on chromosome 2, position 38074574, impacting CYP1B1 (cytochrome P450 family 1 subfamily B member 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Anterior_segment_dysgenesis_6']
CCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCCATCGACAATGTATAAATGAATGGGCATGACTGCGTCAATAAAACGTATATACAA...
CCACTACCTTGAGTCAAAGTGTTAGAAGTCAAAAAACAAGTAACTGATTGTTTGCAACTCCGAAAAAAAATGTATACACGTATGTGATGAAGTGGAGTTATTTTTAGAATCGCTTCTTCAACATTATATTGCAGGAGTCTGCCAACTTTTTTCATAGAAACATGTATGGTGGGGAGAGCCAGAGAGTATCTATTTTAGACTTTGTGGACCAAACCCTCTTTGTTGCACTACTCTGCTCTGCCTTGTGTTGTAGAGTGAACGCAGCCATCGACAATGTATAAATGAATGGGCATGACTGCGTCAATAAAACGTATATACAA...
pathogenic
31,911
Mutation found at chromosome 2 position 38074853, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Anterior_segment_dysgenesis_6', 'CYP1B1-related_disorder', 'Congenital_glaucoma', 'Glaucoma_3,_primary_infantile,_B', 'Glaucoma_3A', 'Primary_congenital_glaucoma']
AAATGAATGGGCATGACTGCGTCAATAAAACGTATATACAAAAACAGATCGTGTAATTTGCCAAGCCCTGTCATACGTCTTTTCACTAAAAAGGAAAAAAAAAGTATCAGCATATTGAATTGAAAGTGACCTCCAAATTGTTTTATTTCTTTTTGCCGCCTAATTGGAGTACTCGGAGAACTATTGTGGTTCTAATGAAAAACAAAGGCCGTTTCAAAAGTTAAAATGCCTATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCC...
AAATGAATGGGCATGACTGCGTCAATAAAACGTATATACAAAAACAGATCGTGTAATTTGCCAAGCCCTGTCATACGTCTTTTCACTAAAAAGGAAAAAAAAAGTATCAGCATATTGAATTGAAAGTGACCTCCAAATTGTTTTATTTCTTTTTGCCGCCTAATTGGAGTACTCGGAGAACTATTGTGGTTCTAATGAAAAACAAAGGCCGTTTCAAAAGTTAAAATGCCTATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCC...
pathogenic
31,920
Evaluate the clinical significance of the mutation at chromosome 2, position 38075025 in gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Congenital_glaucoma']
TCGGAGAACTATTGTGGTTCTAATGAAAAACAAAGGCCGTTTCAAAAGTTAAAATGCCTATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCCTCTCCCTCACCCACCATGGGTGTTTCTATGATTTTAATACTAAAAAGCCATTTTAAGTATACAGAAACTTTTAATTTGTGAAGGTAGCTGTACAGTATCTAAGGAAATATAGATTGCAGTGGATTTTAATAAGGAAAGAGTCATTCTCTGCCTTCCAAACACCTTTCTGTGG...
TCGGAGAACTATTGTGGTTCTAATGAAAAACAAAGGCCGTTTCAAAAGTTAAAATGCCTATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCCTCTCCCTCACCCACCATGGGTGTTTCTATGATTTTAATACTAAAAAGCCATTTTAAGTATACAGAAACTTTTAATTTGTGAAGGTAGCTGTACAGTATCTAAGGAAATATAGATTGCAGTGGATTTTAATAAGGAAAGAGTCATTCTCTGCCTTCCAAACACCTTTCTGTGG...
pathogenic
31,923
Is chromosome 2, position 38075083, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Anterior_segment_dysgenesis_6', 'Primary_congenital_glaucoma']
TATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCCTCTCCCTCACCCACCATGGGTGTTTCTATGATTTTAATACTAAAAAGCCATTTTAAGTATACAGAAACTTTTAATTTGTGAAGGTAGCTGTACAGTATCTAAGGAAATATAGATTGCAGTGGATTTTAATAAGGAAAGAGTCATTCTCTGCCTTCCAAACACCTTTCTGTGGCGCCTGCAGATTCAGCATCTCCAACTGCTCACTTGTGCTCCAAGAAATGACACAAAAC...
TATCTGCGGATGCACAAAAACCTATGGAACCTATTCCGGGATTTCCTTTTCCCTGATCTCTGGTTGACTTTTCTTTATTCGATTTCTGCCTCTCCCTCACCCACCATGGGTGTTTCTATGATTTTAATACTAAAAAGCCATTTTAAGTATACAGAAACTTTTAATTTGTGAAGGTAGCTGTACAGTATCTAAGGAAATATAGATTGCAGTGGATTTTAATAAGGAAAGAGTCATTCTCTGCCTTCCAAACACCTTTCTGTGGCGCCTGCAGATTCAGCATCTCCAACTGCTCACTTGTGCTCCAAGAAATGACACAAAAC...
pathogenic
31,926
Benign or pathogenic: chromosome 2, position 38075874, gene CYP1B1 (cytochrome P450 family 1 subfamily B member 1) variant? Disease(s) if pathogenic?
benign
GCCTCCATGGGCTTCCTTGGCCTGGAACAAAGCCCTGACGGGCGGCCCGCTTTTAGCGCCAGGGCTGGGCGGCCTCGGATGCACGCCGAGGACTAGCCTAGGAGAGGCTGCTGTGTTTAACATATTTATGACATTACCTTTTCTTTCGGAACTATTCCAGTTCTGATTGTAATGCGCCAGGGAGAGAGATATCAGGGCTCATCTCCAAGCATTTAAAAACTCTTGTTTTTCCGGGGGGTGGAGGGGTCTTTGCAAATGTGTTCTCACTCGCAAGCAGGGGAGGGGACGATAGAGACAAGATAGGAGACCGGAGGGGTCGG...
GCCTCCATGGGCTTCCTTGGCCTGGAACAAAGCCCTGACGGGCGGCCCGCTTTTAGCGCCAGGGCTGGGCGGCCTCGGATGCACGCCGAGGACTAGCCTAGGAGAGGCTGCTGTGTTTAACATATTTATGACATTACCTTTTCTTTCGGAACTATTCCAGTTCTGATTGTAATGCGCCAGGGAGAGAGATATCAGGGCTCATCTCCAAGCATTTAAAAACTCTTGTTTTTCCGGGGGGTGGAGGGGTCTTTGCAAATGTGTTCTCACTCGCAAGCAGGGGAGGGGACGATAGAGACAAGATAGGAGACCGGAGGGGTCGG...
benign
31,938
Variant at chromosome 2, position 38983578, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
ACATGCAAAAATAATACACTTGTGGGCTATGTAAGGCATTTTTCTTTATTATTTTTCAGTTTATCTTAGTAATGCCAGAAAAATAACAGCCGTTATTTTCACTTTAAATGCAAACCAAATACTGCTGCACACAGAGTACAAAGATTACCTATGAACATGGTTAGGTACAAAGGCCATATTAGATGTATAGACCACACTTTGTTCTTACATCAAAGACCGACCGACAGAGCAATTTTTTGACAATTATTTTAGCAAATAACCGTGCTACTAAACAAAGGCAAATACACATATATACACAAACACGTCTCAACTAAAATTAT...
ACATGCAAAAATAATACACTTGTGGGCTATGTAAGGCATTTTTCTTTATTATTTTTCAGTTTATCTTAGTAATGCCAGAAAAATAACAGCCGTTATTTTCACTTTAAATGCAAACCAAATACTGCTGCACACAGAGTACAAAGATTACCTATGAACATGGTTAGGTACAAAGGCCATATTAGATGTATAGACCACACTTTGTTCTTACATCAAAGACCGACCGACAGAGCAATTTTTTGACAATTATTTTAGCAAATAACCGTGCTACTAAACAAAGGCAAATACACATATATACACAAACACGTCTCAACTAAAATTAT...
benign
31,962
Does the variant impacting SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) on chromosome 2, position 38984217, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
TTAAAGGCAAAAGGGAAATTTGCTCACAGTCGACAGAAAATGCACTTTACGGTGTCAAAAATGGAAAATAAGGCATGGAATTTACTAAACAAGTTACAAGTGCTTTTGTTGTTTAGATTTATAATATAGACTTCATGCTTCTTAAGTAGAGCTCAAAATATTTCATTGGCTCATGTATAAGGGATTATGAAATAATCTTAAAAGTTAGTAATGAGATGTTTCAAAGAAGAAAAATATTGAATAAAGTCATCATGTTCCCTTATAAATAACTTTACTGCATAATTCTTTCAGCCAAACCAATATTAACCTTGTGATGTTTA...
TTAAAGGCAAAAGGGAAATTTGCTCACAGTCGACAGAAAATGCACTTTACGGTGTCAAAAATGGAAAATAAGGCATGGAATTTACTAAACAAGTTACAAGTGCTTTTGTTGTTTAGATTTATAATATAGACTTCATGCTTCTTAAGTAGAGCTCAAAATATTTCATTGGCTCATGTATAAGGGATTATGAAATAATCTTAAAAGTTAGTAATGAGATGTTTCAAAGAAGAAAAATATTGAATAAAGTCATCATGTTCCCTTATAAATAACTTTACTGCATAATTCTTTCAGCCAAACCAATATTAACCTTGTGATGTTTA...
benign
31,964
Determine if the mutation at chromosome 2, position 38984487 in gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
TTTACTGCATAATTCTTTCAGCCAAACCAATATTAACCTTGTGATGTTTAGTTACTGGTAAAGATTAATGCAATACAACAGGACCTATACTTGCGTAGTCACACAATATATGTTAAAAGAATAAGTAAACCTATTCACAGCAGCAGAATACCAAGAAATAAATGGTTAAACTGTTTCTTTCTAAATCTGAAGGAACAAAAAGGTTTTCTTCAATATGTACAACACTAATAAATTGGGACACTCCTCCTATTTTGCTGAGTCACTTAAAAATCTGAATTTAAGCTGTCATATTAGAAGACAAACAATGAAATACAAGATTA...
TTTACTGCATAATTCTTTCAGCCAAACCAATATTAACCTTGTGATGTTTAGTTACTGGTAAAGATTAATGCAATACAACAGGACCTATACTTGCGTAGTCACACAATATATGTTAAAAGAATAAGTAAACCTATTCACAGCAGCAGAATACCAAGAAATAAATGGTTAAACTGTTTCTTTCTAAATCTGAAGGAACAAAAAGGTTTTCTTCAATATGTACAACACTAATAAATTGGGACACTCCTCCTATTTTGCTGAGTCACTTAAAAATCTGAATTTAAGCTGTCATATTAGAAGACAAACAATGAAATACAAGATTA...
benign
31,965
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 38997474, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): what disease(s) if pathogenic?
benign
TGTAGTAGAAAGGAAAGTTTTTCTATATGTGCCTGGTAAAATTCAGCTAATATACAGGAAAATCATAAATCACTAATAAGGACATAATTATTCAAATAAAAGTAGAACATTTAAAGCATTAACATTCTATTTTGCTAAAGCCCTGGTATCTAAATTGTTAAAGAATGCATTTCTTTAAATAACTAAGTTTTAGTCCTATAAATACTAGAGTATTTGTTATTTTAATACATTTGGGTAGAAGTTTTTCTAAAATGTATTGTATATTTCCCTGGTTTTTAAAACAGACTATTTTGAGCAAATTTAACCTTGTTGAAAAGCCA...
TGTAGTAGAAAGGAAAGTTTTTCTATATGTGCCTGGTAAAATTCAGCTAATATACAGGAAAATCATAAATCACTAATAAGGACATAATTATTCAAATAAAAGTAGAACATTTAAAGCATTAACATTCTATTTTGCTAAAGCCCTGGTATCTAAATTGTTAAAGAATGCATTTCTTTAAATAACTAAGTTTTAGTCCTATAAATACTAGAGTATTTGTTATTTTAATACATTTGGGTAGAAGTTTTTCTAAAATGTATTGTATATTTCCCTGGTTTTTAAAACAGACTATTTTGAGCAAATTTAACCTTGTTGAAAAGCCA...
benign
32,040
Gene mutation in SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) at chromosome 2, position 39006537—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
TAAATAATTTGGGTGGGGAAATAAATTTGAGTATTTCATAAGATATTAAAGATACTTCAGTTTGATATTAGAGTTAAATATAATTTTGAAAGTCATAAAAAAAGCTAGAAGAAAATATGATTATTACTAGATTATATGAACTTTCTAAGGTTAGAAACAATAGAAACCAGAATGAGAAAGGACAGATGGTAGAATTTAAAACTAATACATGTCAATGAATAAAAAGTACAAGGCAGATTGTTTGCAGGAGATACGAAAAATGACATGGACAAGAGGAAATACAAATATTAAAGAATGTATGAAAAAAATCTCCACAGTAA...
TAAATAATTTGGGTGGGGAAATAAATTTGAGTATTTCATAAGATATTAAAGATACTTCAGTTTGATATTAGAGTTAAATATAATTTTGAAAGTCATAAAAAAAGCTAGAAGAAAATATGATTATTACTAGATTATATGAACTTTCTAAGGTTAGAAACAATAGAAACCAGAATGAGAAAGGACAGATGGTAGAATTTAAAACTAATACATGTCAATGAATAAAAAGTACAAGGCAGATTGTTTGCAGGAGATACGAAAAATGACATGGACAAGAGGAAATACAAATATTAAAGAATGTATGAAAAAAATCTCCACAGTAA...
benign
32,047
Is the genetic variant on chromosome 2, position 39006537, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
TAAATAATTTGGGTGGGGAAATAAATTTGAGTATTTCATAAGATATTAAAGATACTTCAGTTTGATATTAGAGTTAAATATAATTTTGAAAGTCATAAAAAAAGCTAGAAGAAAATATGATTATTACTAGATTATATGAACTTTCTAAGGTTAGAAACAATAGAAACCAGAATGAGAAAGGACAGATGGTAGAATTTAAAACTAATACATGTCAATGAATAAAAAGTACAAGGCAGATTGTTTGCAGGAGATACGAAAAATGACATGGACAAGAGGAAATACAAATATTAAAGAATGTATGAAAAAAATCTCCACAGTAA...
TAAATAATTTGGGTGGGGAAATAAATTTGAGTATTTCATAAGATATTAAAGATACTTCAGTTTGATATTAGAGTTAAATATAATTTTGAAAGTCATAAAAAAAGCTAGAAGAAAATATGATTATTACTAGATTATATGAACTTTCTAAGGTTAGAAACAATAGAAACCAGAATGAGAAAGGACAGATGGTAGAATTTAAAACTAATACATGTCAATGAATAAAAAGTACAAGGCAGATTGTTTGCAGGAGATACGAAAAATGACATGGACAAGAGGAAATACAAATATTAAAGAATGTATGAAAAAAATCTCCACAGTAA...
benign
32,048
Variant chromosome 2, position 39007201, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): benign or pathogenic? Disease(s)?
benign
ATTAGGCACAGTAAGATTAAAAATAGCTAAAAGTTACATGAATGTGGTCTTTCTCTCCCAAAATATCTCATGTTTTTGGACCAAAGCTGACCATGGATAACTGAAACCGTGGAAAGTGAAACCGTGGAGATGGGAGCACTACTGTAATTCCTCCTCTGGTTATTTGTCTCAAGAAGATATTTTCAAATACAGAAAAATAGTATAAATGAAAATGTGAATCAGAAAATCATGTGGAAAGCAAAAAAGCTGGAAACAATGTGTCCAATCACAGGGTAATGGTTAAAACAAATTGTCCAACTTTATGGAATATTATGCAGCCA...
ATTAGGCACAGTAAGATTAAAAATAGCTAAAAGTTACATGAATGTGGTCTTTCTCTCCCAAAATATCTCATGTTTTTGGACCAAAGCTGACCATGGATAACTGAAACCGTGGAAAGTGAAACCGTGGAGATGGGAGCACTACTGTAATTCCTCCTCTGGTTATTTGTCTCAAGAAGATATTTTCAAATACAGAAAAATAGTATAAATGAAAATGTGAATCAGAAAATCATGTGGAAAGCAAAAAAGCTGGAAACAATGTGTCCAATCACAGGGTAATGGTTAAAACAAATTGTCCAACTTTATGGAATATTATGCAGCCA...
benign
32,061
Clinical classification of chromosome 2, position 39007201, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): benign or pathogenic? Disease(s) if pathogenic?
benign
ATTAGGCACAGTAAGATTAAAAATAGCTAAAAGTTACATGAATGTGGTCTTTCTCTCCCAAAATATCTCATGTTTTTGGACCAAAGCTGACCATGGATAACTGAAACCGTGGAAAGTGAAACCGTGGAGATGGGAGCACTACTGTAATTCCTCCTCTGGTTATTTGTCTCAAGAAGATATTTTCAAATACAGAAAAATAGTATAAATGAAAATGTGAATCAGAAAATCATGTGGAAAGCAAAAAAGCTGGAAACAATGTGTCCAATCACAGGGTAATGGTTAAAACAAATTGTCCAACTTTATGGAATATTATGCAGCCA...
ATTAGGCACAGTAAGATTAAAAATAGCTAAAAGTTACATGAATGTGGTCTTTCTCTCCCAAAATATCTCATGTTTTTGGACCAAAGCTGACCATGGATAACTGAAACCGTGGAAAGTGAAACCGTGGAGATGGGAGCACTACTGTAATTCCTCCTCTGGTTATTTGTCTCAAGAAGATATTTTCAAATACAGAAAAATAGTATAAATGAAAATGTGAATCAGAAAATCATGTGGAAAGCAAAAAAGCTGGAAACAATGTGTCCAATCACAGGGTAATGGTTAAAACAAATTGTCCAACTTTATGGAATATTATGCAGCCA...
benign
32,062
Does the chromosome 2 mutation at position 39013443 within gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
GTACAGTAATCAATGCATTCACACATCTTTTTTTTTTCTTTTGGTCTAAAGGAGGAGAGGAAAAAAACCTACCACAAAAGGGTCCTAGGAAATAAAATAGATTCTAACACTGTAATTTTCAGAAATACGATTTTCAGTGGGAGATCTATAAATTTATCTCATTTTCTCATTTAGTTATTAAAAAGTGAATAATTTAAGATTCTAAGTAGTCTCCATTTAAAATCAGAAGGACATTTTTGAGATAATTACATCAATGTAGTATGATTAAAAAAGACTATAATGGCTGTAAGTTCACAATAAAGCAGTAGCTAACATTTATT...
GTACAGTAATCAATGCATTCACACATCTTTTTTTTTTCTTTTGGTCTAAAGGAGGAGAGGAAAAAAACCTACCACAAAAGGGTCCTAGGAAATAAAATAGATTCTAACACTGTAATTTTCAGAAATACGATTTTCAGTGGGAGATCTATAAATTTATCTCATTTTCTCATTTAGTTATTAAAAAGTGAATAATTTAAGATTCTAAGTAGTCTCCATTTAAAATCAGAAGGACATTTTTGAGATAATTACATCAATGTAGTATGATTAAAAAAGACTATAATGGCTGTAAGTTCACAATAAAGCAGTAGCTAACATTTATT...
benign
32,076
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 39013443, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). What disease(s) is it linked to if pathogenic?
benign
GTACAGTAATCAATGCATTCACACATCTTTTTTTTTTCTTTTGGTCTAAAGGAGGAGAGGAAAAAAACCTACCACAAAAGGGTCCTAGGAAATAAAATAGATTCTAACACTGTAATTTTCAGAAATACGATTTTCAGTGGGAGATCTATAAATTTATCTCATTTTCTCATTTAGTTATTAAAAAGTGAATAATTTAAGATTCTAAGTAGTCTCCATTTAAAATCAGAAGGACATTTTTGAGATAATTACATCAATGTAGTATGATTAAAAAAGACTATAATGGCTGTAAGTTCACAATAAAGCAGTAGCTAACATTTATT...
GTACAGTAATCAATGCATTCACACATCTTTTTTTTTTCTTTTGGTCTAAAGGAGGAGAGGAAAAAAACCTACCACAAAAGGGTCCTAGGAAATAAAATAGATTCTAACACTGTAATTTTCAGAAATACGATTTTCAGTGGGAGATCTATAAATTTATCTCATTTTCTCATTTAGTTATTAAAAAGTGAATAATTTAAGATTCTAAGTAGTCTCCATTTAAAATCAGAAGGACATTTTTGAGATAATTACATCAATGTAGTATGATTAAAAAAGACTATAATGGCTGTAAGTTCACAATAAAGCAGTAGCTAACATTTATT...
benign
32,077
Variant in gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1), located at chromosome 2 position 39014848: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
AGTGTGAGTTTTGATGTGGCTCTGTTTTATATTGTACATGAAAGTACTATTATTTAACTATTTTCTGATTATCATTTAGAGCATACAAAGGAAATAAAAATAAGTTTGTCTAAGATATCCTTAGAGCCATACACTCACGTAATCTTTAAAACTAGAAGGAAAACCTTAGAGATCGACAAACCTAGCTCCTTATGTTATTGATAAGAAAACTGAAGTCTAAAGAATCTAAGTGATTTTGCCCAAAGTCACGTATCTGATTAGTGGCAGTGTTAGACATAGAGTCTCAATTTAATCCACTCTGCTTCCTCTCTGATTCTATT...
AGTGTGAGTTTTGATGTGGCTCTGTTTTATATTGTACATGAAAGTACTATTATTTAACTATTTTCTGATTATCATTTAGAGCATACAAAGGAAATAAAAATAAGTTTGTCTAAGATATCCTTAGAGCCATACACTCACGTAATCTTTAAAACTAGAAGGAAAACCTTAGAGATCGACAAACCTAGCTCCTTATGTTATTGATAAGAAAACTGAAGTCTAAAGAATCTAAGTGATTTTGCCCAAAGTCACGTATCTGATTAGTGGCAGTGTTAGACATAGAGTCTCAATTTAATCCACTCTGCTTCCTCTCTGATTCTATT...
benign
32,098
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 39035314, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): what disease(s) if pathogenic?
benign
ACAAAATTTCCTGCCCAATATACTGCTAACTTTGCAATATAACTTAGGCAGTAATACGAACAAGGGATACACATGCTTAAATCAGTAGAAATCTTAAATTGCTAAATGATGCACTTATTAAAATTCTATTAATGTAAGTTATAATTTTAGAAATTTTAATTGCCTACACTTGAAGGAGTAAAAATTTCTTTTATATTATTAAGATGATTGGGTTTTATAGCCTTCTGAACTTTCATCAAAGCTTCTTGGGTTCATTTGGAGGGGAAGGTTGTTTTGTTTTGTATTTTTGAGACAGGGGCTTGCTCTGTTTCTCAGGCTGG...
ACAAAATTTCCTGCCCAATATACTGCTAACTTTGCAATATAACTTAGGCAGTAATACGAACAAGGGATACACATGCTTAAATCAGTAGAAATCTTAAATTGCTAAATGATGCACTTATTAAAATTCTATTAATGTAAGTTATAATTTTAGAAATTTTAATTGCCTACACTTGAAGGAGTAAAAATTTCTTTTATATTATTAAGATGATTGGGTTTTATAGCCTTCTGAACTTTCATCAAAGCTTCTTGGGTTCATTTGGAGGGGAAGGTTGTTTTGTTTTGTATTTTTGAGACAGGGGCTTGCTCTGTTTCTCAGGCTGG...
benign
32,167
The genetic variant at chromosome 2, position 39054828, affecting gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): benign or pathogenic? Disease name(s) if pathogenic?
benign
TGTTTTCATTTCTTCTGGGTAAAAACCTAGGAGTAGAATTGCTGGGCAATATGGTTAGTTTATGTTTATTGTTATAAAGAACTGCCAAACTGGCCAGGCATGGTGGCTCACGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGCTGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACCCCGCCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCACACACCTGTAATCCCAGCTACACGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTACAGTGAG...
TGTTTTCATTTCTTCTGGGTAAAAACCTAGGAGTAGAATTGCTGGGCAATATGGTTAGTTTATGTTTATTGTTATAAAGAACTGCCAAACTGGCCAGGCATGGTGGCTCACGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGCTGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACCCCGCCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCACACACCTGTAATCCCAGCTACACGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTACAGTGAG...
benign
32,195
Clinically, how would you classify the variant at chromosome 2, position 39058659, gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
ATACAATTTTATTCTATATGAATAGTACGTTAGCATCTAATAAGTCATAAAAAGAAACTTAAGAAAAAAATAGAAAAGCTCAGTTTCCTACCTTGTCAGCACACATTGCCACTTTAATATCTTGTTTTGTAATTTCATAATGCCGTATATTTCTTACATAATTCCCAACCAGCTTTAAAATGTCTGCAGAAATGTATTCTAAGACTGCTACTATGTAAACAGAAACCTGGTGGTCAATTTTATAACCTAGGACCTCCTGCAAAATTAAAAGAAAAGCATGTTTAAACATCATATACTGTACATTTAACACACTGATTAAA...
ATACAATTTTATTCTATATGAATAGTACGTTAGCATCTAATAAGTCATAAAAAGAAACTTAAGAAAAAAATAGAAAAGCTCAGTTTCCTACCTTGTCAGCACACATTGCCACTTTAATATCTTGTTTTGTAATTTCATAATGCCGTATATTTCTTACATAATTCCCAACCAGCTTTAAAATGTCTGCAGAAATGTATTCTAAGACTGCTACTATGTAAACAGAAACCTGGTGGTCAATTTTATAACCTAGGACCTCCTGCAAAATTAAAAGAAAAGCATGTTTAAACATCATATACTGTACATTTAACACACTGATTAAA...
benign
32,208
Does the genetic variant at chromosome 2, position 39067611, impacting gene SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
CTTTCAGATGTCCTAATATTATCAGTTCTCTGACCTTACTGAGAACTCTAGTACCCTTTTCTCTCCATGTTTTTCCATTATATGTGCCCTCTCCTACCTGGTATCAGAATGCATGCTCAAAAAGCTAGACTTTCTGGTTAAAAGTCTTGGCTTCACTACTTAATAACTTGGGCAGGTTATTCAACCTCTCTGTGCTTCAGTTGAATCATTCATTCAACTTATATTTTCTGAGTGTCTTCTCTGTGCCAGATATTGCTCTAGGTGCTGATGATTCAACAGTGAACAACAACAACAAAAATTCCCTGGAGCTTACATTCTAG...
CTTTCAGATGTCCTAATATTATCAGTTCTCTGACCTTACTGAGAACTCTAGTACCCTTTTCTCTCCATGTTTTTCCATTATATGTGCCCTCTCCTACCTGGTATCAGAATGCATGCTCAAAAAGCTAGACTTTCTGGTTAAAAGTCTTGGCTTCACTACTTAATAACTTGGGCAGGTTATTCAACCTCTCTGTGCTTCAGTTGAATCATTCATTCAACTTATATTTTCTGAGTGTCTTCTCTGTGCCAGATATTGCTCTAGGTGCTGATGATTCAACAGTGAACAACAACAACAAAAATTCCCTGGAGCTTACATTCTAG...
benign
32,222
Considering the variant on chromosome 2, location 42048690, involving gene PKDCC, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Rhizomelic_limb_shortening_with_dysmorphic_features']
GAACGCCAGACCTCTTCAGGGAAAATCTCCCCTCCCTGGATACCCCCCCACCCACCCCCACCCCCAGAAAAAAGGCTGTGGACCCTTCTCCTCCCTGACCCCTCCCCAGCCAATCCCTGACACTGTGAGGAGGACAGAGATTAACCTGGCCCAGAGGGAGGCAGGAAGCTGCCCAGGAAGGTGAGAGGATCTAGGTGGGCAGTTTCAGAGTGGCGGGGAAGAGGAGAGCTGCGAGGGGGAGGGGCAGCGGCTTATCTCTCCCAGGAGGGGGGAGCTCACTCCAAACAGCTAGTGCACTGGCGTGTGAAAGCCCCTCAATT...
GAACGCCAGACCTCTTCAGGGAAAATCTCCCCTCCCTGGATACCCCCCCACCCACCCCCACCCCCAGAAAAAAGGCTGTGGACCCTTCTCCTCCCTGACCCCTCCCCAGCCAATCCCTGACACTGTGAGGAGGACAGAGATTAACCTGGCCCAGAGGGAGGCAGGAAGCTGCCCAGGAAGGTGAGAGGATCTAGGTGGGCAGTTTCAGAGTGGCGGGGAAGAGGAGAGCTGCGAGGGGGAGGGGCAGCGGCTTATCTCTCCCAGGAGGGGGGAGCTCACTCCAAACAGCTAGTGCACTGGCGTGTGAAAGCCCCTCAATT...
pathogenic
32,250
Does the variant on chromosome 2 at location 42048804 affecting gene PKDCC have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Rhizomelic_limb_shortening_with_dysmorphic_features']
CCCTGACACTGTGAGGAGGACAGAGATTAACCTGGCCCAGAGGGAGGCAGGAAGCTGCCCAGGAAGGTGAGAGGATCTAGGTGGGCAGTTTCAGAGTGGCGGGGAAGAGGAGAGCTGCGAGGGGGAGGGGCAGCGGCTTATCTCTCCCAGGAGGGGGGAGCTCACTCCAAACAGCTAGTGCACTGGCGTGTGAAAGCCCCTCAATTAGCACTAATGATGCAATCAGGGAGGGAGGAGGAGGGACCGAAGTTCTGGTGGCGTCAGCACCAACTTACACACAAGGTACACATTCCCTTCATCGGACACAATGGCCCCTTCAG...
CCCTGACACTGTGAGGAGGACAGAGATTAACCTGGCCCAGAGGGAGGCAGGAAGCTGCCCAGGAAGGTGAGAGGATCTAGGTGGGCAGTTTCAGAGTGGCGGGGAAGAGGAGAGCTGCGAGGGGGAGGGGCAGCGGCTTATCTCTCCCAGGAGGGGGGAGCTCACTCCAAACAGCTAGTGCACTGGCGTGTGAAAGCCCCTCAATTAGCACTAATGATGCAATCAGGGAGGGAGGAGGAGGGACCGAAGTTCTGGTGGCGTCAGCACCAACTTACACACAAGGTACACATTCCCTTCATCGGACACAATGGCCCCTTCAG...
pathogenic
32,252
A mutation at chromosome position 42770143 on chromosome 2 in gene HAAO (3-hydroxyanthranilate 3,4-dioxygenase): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Congenital_NAD_deficiency_disorder', 'Vertebral,_cardiac,_renal,_and_limb_defects_syndrome_1']
CTGGGCTGCAGGCCTCCCTGTGCCCGCCGCTGCAACAGGTATTTGGGATCACACATGCCTGCCTTTCACGTGCAGTGCACCCGTGGTCCCTCTGATGTGTGCTCATGCGAAGGCATGCTCACCAGGGCACATGAGGGACGCATTTCCATCAGCTTCCCAGAGGGTGCCACCTCCCTTTCTCTGAGAGAGGTTATGAGTCTGGCCTCAGGAGGAGGAGGGGACAAGGAAGGTGAGGCTGAGGGCTCTCTGACATGCACCAGCCTGGAAGCACACAGCTACTGTGCAGGGCCGTGCTGCTGATGCCCTGGAGAGGGTGCATA...
CTGGGCTGCAGGCCTCCCTGTGCCCGCCGCTGCAACAGGTATTTGGGATCACACATGCCTGCCTTTCACGTGCAGTGCACCCGTGGTCCCTCTGATGTGTGCTCATGCGAAGGCATGCTCACCAGGGCACATGAGGGACGCATTTCCATCAGCTTCCCAGAGGGTGCCACCTCCCTTTCTCTGAGAGAGGTTATGAGTCTGGCCTCAGGAGGAGGAGGGGACAAGGAAGGTGAGGCTGAGGGCTCTCTGACATGCACCAGCCTGGAAGCACACAGCTACTGTGCAGGGCCGTGCTGCTGATGCCCTGGAGAGGGTGCATA...
pathogenic
32,266
Clinically, how would you classify the variant at chromosome 2, position 43824358, gene DYNC2LI1: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Sitosterolemia']
CCTTGAAACTCTCTCCTTCCTCATCCTCTCTGATGCTGCCCAATCCTGCTTCTCTTTCTACCTCCCTGATCACCCTCTGCCTCCTCTGTTGGTTGCTGTCCTCTTCCCACCCTCTGAATGTGTCTGTTTTAAGGTTTTACATTCAGGCTGCTTTCTCCCCTCCCCCAGGCCCCCCCCCATGCACCTGGGTCCTAGCTACTTCAGAGTCCTCTCTTCTCTGGCCCAGGCCCTGCCGTGAATGTGGGACAGGTCATTCCCAGGCACATGTCATCTTGTTGGTTTGTTCTCAGGTCTCCTGCAACCCACAGTTGGGCTATTTA...
CCTTGAAACTCTCTCCTTCCTCATCCTCTCTGATGCTGCCCAATCCTGCTTCTCTTTCTACCTCCCTGATCACCCTCTGCCTCCTCTGTTGGTTGCTGTCCTCTTCCCACCCTCTGAATGTGTCTGTTTTAAGGTTTTACATTCAGGCTGCTTTCTCCCCTCCCCCAGGCCCCCCCCCATGCACCTGGGTCCTAGCTACTTCAGAGTCCTCTCTTCTCTGGCCCAGGCCCTGCCGTGAATGTGGGACAGGTCATTCCCAGGCACATGTCATCTTGTTGGTTTGTTCTCAGGTCTCCTGCAACCCACAGTTGGGCTATTTA...
pathogenic
32,348
Located at chromosome 2 position 43828041, the variant affecting gene DYNC2LI1—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Cardiovascular_phenotype', 'Sitosterolemia', 'Sitosterolemia_1']
TGAGATGAGGTCTTCCTCTGTCACCCAGGCTAGAGTGCAATGGCATGATCACGACTCCCTGCAGCCTTGACCTACTGGGCTCAAGCGATCCTCTCACCTCAGCCTTCCAAGTAGCTGGGACCACAGATATGCACCACCATGCCTGGCTAATTTTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTAGAGATGGGGAGTCTCACTTTATTGCTCAGGATGGACTCAAACTCCTGGCCTCAAGTGCTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGAATTACAAGTGTGAGCCACTGTGCCTGGCCACTGGTACAAATC...
TGAGATGAGGTCTTCCTCTGTCACCCAGGCTAGAGTGCAATGGCATGATCACGACTCCCTGCAGCCTTGACCTACTGGGCTCAAGCGATCCTCTCACCTCAGCCTTCCAAGTAGCTGGGACCACAGATATGCACCACCATGCCTGGCTAATTTTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTAGAGATGGGGAGTCTCACTTTATTGCTCAGGATGGACTCAAACTCCTGGCCTCAAGTGCTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGAATTACAAGTGTGAGCCACTGTGCCTGGCCACTGGTACAAATC...
pathogenic
32,364
Chromosome 2, position 43831752, gene ABCG5 (ATP binding cassette subfamily G member 5): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
CTCATATGGTAATAAGTTTTGTTTCCAGACACCCCTAATAAGGCCGTGTTATGAAAATGGAAACAAAACCATTGCATTAAAAAACAATAAGCTAGATTGCAGAAGAAGAGGGAATGACTTGTGGACCAACATTCAAGAGGAGTCAGGGAGTGGGGTTGACGGCATAGATGTAGCTTTGACCCACCCAAAGAATGGACATATCTGAAATAGGTACAAAGGAATAATGAGAAGGTAAAAATGCATAAATAAACTAGATATAGATATATTCTGGAACAAAAGAAAGCTCTTCTCTTGCCATCAGGGTAGAAGGATCCTAGAAT...
CTCATATGGTAATAAGTTTTGTTTCCAGACACCCCTAATAAGGCCGTGTTATGAAAATGGAAACAAAACCATTGCATTAAAAAACAATAAGCTAGATTGCAGAAGAAGAGGGAATGACTTGTGGACCAACATTCAAGAGGAGTCAGGGAGTGGGGTTGACGGCATAGATGTAGCTTTGACCCACCCAAAGAATGGACATATCTGAAATAGGTACAAAGGAATAATGAGAAGGTAAAAATGCATAAATAAACTAGATATAGATATATTCTGGAACAAAAGAAAGCTCTTCTCTTGCCATCAGGGTAGAAGGATCCTAGAAT...
benign
32,371
Variant on chromosome 2, at position 43851805, affecting ABCG8 (ATP binding cassette subfamily G member 8): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Sitosterolemia_1']
CTCTCCTGGCTATTTTGTTCCACTCATGTTCTCAGGGATCTTAAATGAGGTACACCCAGAGGTGGTGCACAGGCCCCTTCTACCCTGAGAGCCTCTGCACAGTAACCAGAAAGATCATGTGAAGAAGCTTCTTGGTTTTTGGAGATCAAAACTCCATCTGGGGCCGGGCACGGTGGCTCACGTCTGTCATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCGCTGCTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGTGTGG...
CTCTCCTGGCTATTTTGTTCCACTCATGTTCTCAGGGATCTTAAATGAGGTACACCCAGAGGTGGTGCACAGGCCCCTTCTACCCTGAGAGCCTCTGCACAGTAACCAGAAAGATCATGTGAAGAAGCTTCTTGGTTTTTGGAGATCAAAACTCCATCTGGGGCCGGGCACGGTGGCTCACGTCTGTCATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCGCTGCTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGTGTGG...
pathogenic
32,414
Clinically, how would you classify the variant at chromosome 2, position 43852436, gene ABCG8 (ATP binding cassette subfamily G member 8): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['ABCG8-related_disorder', 'Sitosterolemia']
CTCAAATCAATAATAATTAGTACATCATTCAGAAGAGGGTGCTGTTAACTTGAGTGCAATGAATCTTTTTTTAACTTTTATTTTAGGTTTGGGGATGCACAAGTAGGTTTGTTATATAGGTAAACTAGTGTCACGGGGTTTTGTTGTACAGATTATTTAATCACCCAGGTAGTAAGCTTTGTACCCAAGTGTTTTTTCCTGCTCTCCCTCCTCCCATCCTCCACCCTCAGTTAGGTGAATCCTTTTTTAAAAAAGAGTATTAAAAATACCACTGATGCACTTTGGGAGGCCCAGGCGGGTAGATCACCTGAGGTCAGGAG...
CTCAAATCAATAATAATTAGTACATCATTCAGAAGAGGGTGCTGTTAACTTGAGTGCAATGAATCTTTTTTTAACTTTTATTTTAGGTTTGGGGATGCACAAGTAGGTTTGTTATATAGGTAAACTAGTGTCACGGGGTTTTGTTGTACAGATTATTTAATCACCCAGGTAGTAAGCTTTGTACCCAAGTGTTTTTTCCTGCTCTCCCTCCTCCCATCCTCCACCCTCAGTTAGGTGAATCCTTTTTTAAAAAAGAGTATTAAAAATACCACTGATGCACTTTGGGAGGCCCAGGCGGGTAGATCACCTGAGGTCAGGAG...
pathogenic
32,421
Variant at chromosome 2, position 43852581, gene ABCG8 (ATP binding cassette subfamily G member 8): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
GTACAGATTATTTAATCACCCAGGTAGTAAGCTTTGTACCCAAGTGTTTTTTCCTGCTCTCCCTCCTCCCATCCTCCACCCTCAGTTAGGTGAATCCTTTTTTAAAAAAGAGTATTAAAAATACCACTGATGCACTTTGGGAGGCCCAGGCGGGTAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTCGCCAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTAGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGGAGAATTGCTTGAACTCGGGAGGCAGAGATTGCAG...
GTACAGATTATTTAATCACCCAGGTAGTAAGCTTTGTACCCAAGTGTTTTTTCCTGCTCTCCCTCCTCCCATCCTCCACCCTCAGTTAGGTGAATCCTTTTTTAAAAAAGAGTATTAAAAATACCACTGATGCACTTTGGGAGGCCCAGGCGGGTAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTCGCCAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTAGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGGAGAATTGCTTGAACTCGGGAGGCAGAGATTGCAG...
benign
32,424
A genetic alteration at chromosome 2, position 43874075, in gene ABCG8 (ATP binding cassette subfamily G member 8)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
GGGAGAAGGCTCAGTCACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAGGTAAGGTGGCAGGCGACTCTGAGAGGAGAGCTCCCTGCAGAAGGTGGCTGCCCCCATGACCTGGCCACATCTTCTGCCTCCCAGCAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGGTAATTATCTGTCATTTTATTACTGAACCCGCCCCCCTGC...
GGGAGAAGGCTCAGTCACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTATGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAGGTAAGGTGGCAGGCGACTCTGAGAGGAGAGCTCCCTGCAGAAGGTGGCTGCCCCCATGACCTGGCCACATCTTCTGCCTCCCAGCAGCGTGACCCCACTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACGACGCTGATCCGGTAATTATCTGTCATTTTATTACTGAACCCGCCCCCCTGC...
benign
32,460
Mutation at chromosome 2, position 43874398, within ABCG8 (ATP binding cassette subfamily G member 8): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
AGTCTTTGTATATCACATTAAGCCCTTTCTATTAAAGTGAATTTAAAGGAGAAAGTGAGAGGTAGAGTCATTTGAAAAAAACAGCATCCAGCAGGGCGTTGGTGGCTTATGCCTGTAATCCCAGCACTCTGGGAGGCTGTGGTGCGTGGATCACTTAAGTTCAGGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAAGCCCATCTCTACAAAAAATTATAAAAAGTAGCCAGTTATGGTGGCGTGGGCCTACCTGGTAGGCTGAGGTGGGAGGATTGCTTGATTCCTGGAGGTGGAGGCTGCAGTGAGCCGTGATTGCAC...
AGTCTTTGTATATCACATTAAGCCCTTTCTATTAAAGTGAATTTAAAGGAGAAAGTGAGAGGTAGAGTCATTTGAAAAAAACAGCATCCAGCAGGGCGTTGGTGGCTTATGCCTGTAATCCCAGCACTCTGGGAGGCTGTGGTGCGTGGATCACTTAAGTTCAGGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAAGCCCATCTCTACAAAAAATTATAAAAAGTAGCCAGTTATGGTGGCGTGGGCCTACCTGGTAGGCTGAGGTGGGAGGATTGCTTGATTCCTGGAGGTGGAGGCTGCAGTGAGCCGTGATTGCAC...
benign
32,465
For chromosome 2, position 43874438, gene ABCG8 (ATP binding cassette subfamily G member 8): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Sitosterolemia_1']
ATTTAAAGGAGAAAGTGAGAGGTAGAGTCATTTGAAAAAAACAGCATCCAGCAGGGCGTTGGTGGCTTATGCCTGTAATCCCAGCACTCTGGGAGGCTGTGGTGCGTGGATCACTTAAGTTCAGGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAAGCCCATCTCTACAAAAAATTATAAAAAGTAGCCAGTTATGGTGGCGTGGGCCTACCTGGTAGGCTGAGGTGGGAGGATTGCTTGATTCCTGGAGGTGGAGGCTGCAGTGAGCCGTGATTGCACCTTCACTCCAGCCTAGGCAGCAGAGCAAGACCCCATCTCA...
ATTTAAAGGAGAAAGTGAGAGGTAGAGTCATTTGAAAAAAACAGCATCCAGCAGGGCGTTGGTGGCTTATGCCTGTAATCCCAGCACTCTGGGAGGCTGTGGTGCGTGGATCACTTAAGTTCAGGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAAGCCCATCTCTACAAAAAATTATAAAAAGTAGCCAGTTATGGTGGCGTGGGCCTACCTGGTAGGCTGAGGTGGGAGGATTGCTTGATTCCTGGAGGTGGAGGCTGCAGTGAGCCGTGATTGCACCTTCACTCCAGCCTAGGCAGCAGAGCAAGACCCCATCTCA...
pathogenic
32,467
Gene LRPPRC (leucine rich pentatricopeptide repeat containing) variant at chromosome position 43889850 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TCATAGATGAAATCACATCTTTTCAGGATATGAGTATAAAGTAACAAGCCTAGGGCAGAGCTTGTACTGACAAAGTCCTGAAACTACAATGAGAGGAAACACATTGCTCTACTTCGGGATAAGTCATGACCGAGACTCAATTTCAGAGACGCTCTATGAACAGAGGTGCTTGAAGCCACAGTGGCAGAAGGGAAAGATGGGGAAGTGTGCCGAAGAGCCTCCAGGCATGACAGACAGTCCCCTGACCAAGCACAAGTAACAGGCCCTTTGGGTCTCTGCTTCTCACTGGAAAATGATGAAGCCTAGATCTGATGACTCCT...
TCATAGATGAAATCACATCTTTTCAGGATATGAGTATAAAGTAACAAGCCTAGGGCAGAGCTTGTACTGACAAAGTCCTGAAACTACAATGAGAGGAAACACATTGCTCTACTTCGGGATAAGTCATGACCGAGACTCAATTTCAGAGACGCTCTATGAACAGAGGTGCTTGAAGCCACAGTGGCAGAAGGGAAAGATGGGGAAGTGTGCCGAAGAGCCTCCAGGCATGACAGACAGTCCCCTGACCAAGCACAAGTAACAGGCCCTTTGGGTCTCTGCTTCTCACTGGAAAATGATGAAGCCTAGATCTGATGACTCCT...
pathogenic
32,507
The mutation impacting LRPPRC (leucine rich pentatricopeptide repeat containing) on chromosome 2 at position 43894526: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
GTATTTAAAGCCTGCTGTAGAGACCTACTGCTCAGGAAAAAAAAGATTCCTTTCAAAATATTACTGCTCAGTGATAATGCACCTGGTCACCCAAGAGCTCTGAAGGAGATATACAGGGAGATTAATGTTGTTCTCAGGTGCCCTAATAAAACATCCATTCTGCAGCCCATAGATCAAGGAGTAATCTTGACTTTCAAGTCTTAACACATTTTGGGCTCACTTCGGCAACACATATACTGAAATTGGAATGATACAGAGAAGATTAGCATGGCCCCTGCACAAAGATGACACGCAAATGTGTAAAGCGTTCCATGTTTTAA...
GTATTTAAAGCCTGCTGTAGAGACCTACTGCTCAGGAAAAAAAAGATTCCTTTCAAAATATTACTGCTCAGTGATAATGCACCTGGTCACCCAAGAGCTCTGAAGGAGATATACAGGGAGATTAATGTTGTTCTCAGGTGCCCTAATAAAACATCCATTCTGCAGCCCATAGATCAAGGAGTAATCTTGACTTTCAAGTCTTAACACATTTTGGGCTCACTTCGGCAACACATATACTGAAATTGGAATGATACAGAGAAGATTAGCATGGCCCCTGCACAAAGATGACACGCAAATGTGTAAAGCGTTCCATGTTTTAA...
benign
32,510
Clinical significance of chromosome 2, position 43894549, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CCTACTGCTCAGGAAAAAAAAGATTCCTTTCAAAATATTACTGCTCAGTGATAATGCACCTGGTCACCCAAGAGCTCTGAAGGAGATATACAGGGAGATTAATGTTGTTCTCAGGTGCCCTAATAAAACATCCATTCTGCAGCCCATAGATCAAGGAGTAATCTTGACTTTCAAGTCTTAACACATTTTGGGCTCACTTCGGCAACACATATACTGAAATTGGAATGATACAGAGAAGATTAGCATGGCCCCTGCACAAAGATGACACGCAAATGTGTAAAGCGTTCCATGTTTTAAACATAAAATTAAAAAAAAAAAAC...
CCTACTGCTCAGGAAAAAAAAGATTCCTTTCAAAATATTACTGCTCAGTGATAATGCACCTGGTCACCCAAGAGCTCTGAAGGAGATATACAGGGAGATTAATGTTGTTCTCAGGTGCCCTAATAAAACATCCATTCTGCAGCCCATAGATCAAGGAGTAATCTTGACTTTCAAGTCTTAACACATTTTGGGCTCACTTCGGCAACACATATACTGAAATTGGAATGATACAGAGAAGATTAGCATGGCCCCTGCACAAAGATGACACGCAAATGTGTAAAGCGTTCCATGTTTTAAACATAAAATTAAAAAAAAAAAAC...
pathogenic
32,511
Clinical classification of chromosome 2, position 43899270, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
AAAAGGCTTTCACTGCAACAGACAGCCAGCGCTTGAGAAAGAGACCAAAGTTAAACTAAAAAAAAAAGTTTACATGACAGACCAGATAAATCAAATGTCTATCCAATCTTAGATGCTATAGTAAAATCAAATATGGCAAGACAATATTTTAGTTTACACTCATCACAGATGTCATTCTTTTAAGTTTCTAAAAGAACACTGCTCTTTCAAAGCTTTAAAACACTGTCAATACTAAAACGAATGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTA...
AAAAGGCTTTCACTGCAACAGACAGCCAGCGCTTGAGAAAGAGACCAAAGTTAAACTAAAAAAAAAAGTTTACATGACAGACCAGATAAATCAAATGTCTATCCAATCTTAGATGCTATAGTAAAATCAAATATGGCAAGACAATATTTTAGTTTACACTCATCACAGATGTCATTCTTTTAAGTTTCTAAAAGAACACTGCTCTTTCAAAGCTTTAAAACACTGTCAATACTAAAACGAATGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTA...
pathogenic
32,522
A genetic variant on chromosome 2, position 43899303, affects the gene LRPPRC (leucine rich pentatricopeptide repeat containing). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TGAGAAAGAGACCAAAGTTAAACTAAAAAAAAAAGTTTACATGACAGACCAGATAAATCAAATGTCTATCCAATCTTAGATGCTATAGTAAAATCAAATATGGCAAGACAATATTTTAGTTTACACTCATCACAGATGTCATTCTTTTAAGTTTCTAAAAGAACACTGCTCTTTCAAAGCTTTAAAACACTGTCAATACTAAAACGAATGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTATTCTTCGCTACGGCAAGAATAATCTTTTACTGT...
TGAGAAAGAGACCAAAGTTAAACTAAAAAAAAAAGTTTACATGACAGACCAGATAAATCAAATGTCTATCCAATCTTAGATGCTATAGTAAAATCAAATATGGCAAGACAATATTTTAGTTTACACTCATCACAGATGTCATTCTTTTAAGTTTCTAAAAGAACACTGCTCTTTCAAAGCTTTAAAACACTGTCAATACTAAAACGAATGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTATTCTTCGCTACGGCAAGAATAATCTTTTACTGT...
pathogenic
32,523
Regarding the variant at chromosome 2 and position 43899511, affecting gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTATTCTTCGCTACGGCAAGAATAATCTTTTACTGTTTGACAAGCAGGTAAAGGATGGGTGAAGGGTTTATCATCTGAAACCCCAGTCTAGTGATGAGATGGTAAATGAAAAGACTCTGCTGTTGCATCAACACTCAGCTACCACCAAGAGCCCTTCAGTGAGGTCACTGCAGATAACGCAGTTCTTTCTGAGGGAGCAGGCGCCATCCCTGCTGCCACCCACCCAGGCGGCTGTCAATTGTGC...
TGGTATAAAAAGAACTTTTTGGGGCCACACAGAACATTTACATTACGCACTGATGTTTTTGACATCTGTGAATAAAGTATTCTTCGCTACGGCAAGAATAATCTTTTACTGTTTGACAAGCAGGTAAAGGATGGGTGAAGGGTTTATCATCTGAAACCCCAGTCTAGTGATGAGATGGTAAATGAAAAGACTCTGCTGTTGCATCAACACTCAGCTACCACCAAGAGCCCTTCAGTGAGGTCACTGCAGATAACGCAGTTCTTTCTGAGGGAGCAGGCGCCATCCCTGCTGCCACCCACCCAGGCGGCTGTCAATTGTGC...
pathogenic
32,525
Does the variant on chromosome 2 at location 43901322 affecting gene LRPPRC (leucine rich pentatricopeptide repeat containing) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
AAATCAGTGACAGGTTTATAAATTGCAAACTGATTGGCCAATCTCTCCGCCATGATGCTTACTGGAAAAATGACAGGTAAGAAAAATCTTTCATTAGAACAGTGGTATAACTCACCTACCAAAGAAATTTGGTCTAGTCTCACTAGAGAGAAAATGTGCTTGTGTGTTCTTTAGCACAAACAACTAACTTACTCTTTTCAACTGCTGGTTCCAACTGCTCCTCTATTACTTTTCTGAATAAGTATGCCAAGCCGAAGTATTGGGGTTCAATGACTTTATTCTCTGAAGTAAGCATATTTTCAATGTTTTCTATTGCGGCA...
AAATCAGTGACAGGTTTATAAATTGCAAACTGATTGGCCAATCTCTCCGCCATGATGCTTACTGGAAAAATGACAGGTAAGAAAAATCTTTCATTAGAACAGTGGTATAACTCACCTACCAAAGAAATTTGGTCTAGTCTCACTAGAGAGAAAATGTGCTTGTGTGTTCTTTAGCACAAACAACTAACTTACTCTTTTCAACTGCTGGTTCCAACTGCTCCTCTATTACTTTTCTGAATAAGTATGCCAAGCCGAAGTATTGGGGTTCAATGACTTTATTCTCTGAAGTAAGCATATTTTCAATGTTTTCTATTGCGGCA...
pathogenic
32,529
The mutation in gene LRPPRC (leucine rich pentatricopeptide repeat containing) at chromosome 2, position 43905745—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TCCTGTAGCTTACACAGGGCACCTAACATAAAAATAAAGGGTACCAATCCAGCTGAAGAAATCTGGGTCAGGTTCAGCTGAAAAATGAACCCCCTGAAATTAGAAAAGTGTTTTGTTCTTATCTCCATGTCTACAGAAACAAAAGCTATTTATGACAATGAGCTTATTTATATGGCGAGCAAGTTTAACTTTTCATTGTTTTAAAATTGTTTATCATTTTATTACATAAAATACTAATAGGACATAAAGTCTTTTTTGGGGGGGCCGGGAGAAGGGTTTTGTTCTTGCCCAGGCTGAGTGCAGTGGCACCATCATGGCTC...
TCCTGTAGCTTACACAGGGCACCTAACATAAAAATAAAGGGTACCAATCCAGCTGAAGAAATCTGGGTCAGGTTCAGCTGAAAAATGAACCCCCTGAAATTAGAAAAGTGTTTTGTTCTTATCTCCATGTCTACAGAAACAAAAGCTATTTATGACAATGAGCTTATTTATATGGCGAGCAAGTTTAACTTTTCATTGTTTTAAAATTGTTTATCATTTTATTACATAAAATACTAATAGGACATAAAGTCTTTTTTGGGGGGGCCGGGAGAAGGGTTTTGTTCTTGCCCAGGCTGAGTGCAGTGGCACCATCATGGCTC...
pathogenic
32,534
Considering the genetic mutation at chromosome 2, position 43912451, impacting LRPPRC (leucine rich pentatricopeptide repeat containing): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TTTTATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGGGATCCTTCCGCCTTGGCCTCCGAAAGTGTTGGGATTACAGGCATGAGCCAACGTGCCTGGGCTTAAATCTCTTTTTAAAAATTTCACCTTATGAAGATTTTCTATTTTGAGTATGTTTTATAATATAGTTACATGTGATACATCAAGTACAATTTGTTATTAATCACATGCGATCAGAATGCTTAAGACATGATTCTTCAATCACTTGGGCTATGGAGTAAAATGTACATTCTCAGGCCCCACACCAAAT...
TTTTATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGGGATCCTTCCGCCTTGGCCTCCGAAAGTGTTGGGATTACAGGCATGAGCCAACGTGCCTGGGCTTAAATCTCTTTTTAAAAATTTCACCTTATGAAGATTTTCTATTTTGAGTATGTTTTATAATATAGTTACATGTGATACATCAAGTACAATTTGTTATTAATCACATGCGATCAGAATGCTTAAGACATGATTCTTCAATCACTTGGGCTATGGAGTAAAATGTACATTCTCAGGCCCCACACCAAAT...
pathogenic
32,537
The chromosome 2, position 43918025 genetic variant in gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CAGGTCTCAAACTCCTGGACTCAAGTGATCTGCCCACCTTGGCCTCCCAAGTTGTTGGGATTATAGGCATGAGCCTGCAAGCCTGGCCAAACCTTCTAGTTAAGTTAGGAAATTAAGAAGTTCTATAAATTTCTAAATTGATTCCTTTCCAATAAACCTCAAAACTATCAATACTAAAATAAAAAAATTCTCTTGTGTTTATTTCCTTAATGGTAAACTATCATGAACCATCCTTGAAATCCACCCCAAAACTGAAGGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAAT...
CAGGTCTCAAACTCCTGGACTCAAGTGATCTGCCCACCTTGGCCTCCCAAGTTGTTGGGATTATAGGCATGAGCCTGCAAGCCTGGCCAAACCTTCTAGTTAAGTTAGGAAATTAAGAAGTTCTATAAATTTCTAAATTGATTCCTTTCCAATAAACCTCAAAACTATCAATACTAAAATAAAAAAATTCTCTTGTGTTTATTTCCTTAATGGTAAACTATCATGAACCATCCTTGAAATCCACCCCAAAACTGAAGGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAAT...
pathogenic
32,538
For chromosome 2, position 43918025, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CAGGTCTCAAACTCCTGGACTCAAGTGATCTGCCCACCTTGGCCTCCCAAGTTGTTGGGATTATAGGCATGAGCCTGCAAGCCTGGCCAAACCTTCTAGTTAAGTTAGGAAATTAAGAAGTTCTATAAATTTCTAAATTGATTCCTTTCCAATAAACCTCAAAACTATCAATACTAAAATAAAAAAATTCTCTTGTGTTTATTTCCTTAATGGTAAACTATCATGAACCATCCTTGAAATCCACCCCAAAACTGAAGGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAAT...
CAGGTCTCAAACTCCTGGACTCAAGTGATCTGCCCACCTTGGCCTCCCAAGTTGTTGGGATTATAGGCATGAGCCTGCAAGCCTGGCCAAACCTTCTAGTTAAGTTAGGAAATTAAGAAGTTCTATAAATTTCTAAATTGATTCCTTTCCAATAAACCTCAAAACTATCAATACTAAAATAAAAAAATTCTCTTGTGTTTATTTCCTTAATGGTAAACTATCATGAACCATCCTTGAAATCCACCCCAAAACTGAAGGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAAT...
pathogenic
32,539
Gene LRPPRC (leucine rich pentatricopeptide repeat containing) variant at chromosome position 43918281 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
GGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAA...
GGAATCATTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAA...
pathogenic
32,543
Variant in gene LRPPRC (leucine rich pentatricopeptide repeat containing), located at chromosome 2 position 43918288: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAAGTTATAA...
TTCTATGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAAGTTATAA...
pathogenic
32,544
Does the genetic variant at chromosome 2, position 43918293, impacting gene LRPPRC (leucine rich pentatricopeptide repeat containing), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAAGTTATAATATGT...
TGGAAAGCTAGAATGAAAAGAAATTAACAAAAGTAAAGAAAATAAGAGTAATATATGATTCTGGAACAGTATAAGAAGTCTAAGTAAAAACATAAAATTCAACTTACAAGCTCATAACAGAGGGTTAAAGACGGTCATAAAAAATTTAAAGTAGGCATAATAAAGGTGAAGATGTCTTCAGGAAAGTTTAATACTAGAGAAAGGGAAAGAGTCAAGAAACAGACCTCTAACCTTGAGATATTGCTGGATCACTTCAACACATACTAGTATAGTAATTAATGCCTTAATCATTTTTTGCTTTCAAGTAAGTTATAATATGT...
pathogenic
32,545
Clinically, how would you classify the variant at chromosome 2, position 43934197, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
AAAAAGACTGGAGACTGTCAAATATACTACATATAACACATGATACATGTATGCCAATTCATCTTAAAAACAAACAAACAAAAAAACAGGTGATATTTACACATTGAACCTTGCCTATATCTTTCTTCATTTAATGAGCTTATGACTGGTTTATCTAATTATTTCCACAACGCTTCAAATACACAGCAGCTCTGTAAATTCAACCATAGTGAATCTACCCAATGATAAGACACTATTGCTTTTTTTGGGAATGATAAAAATGTTGCTCATGACTTGTAGTATTCTTTCTGTAAAGCTATTCTTCACCCTTTAAAAAATTT...
AAAAAGACTGGAGACTGTCAAATATACTACATATAACACATGATACATGTATGCCAATTCATCTTAAAAACAAACAAACAAAAAAACAGGTGATATTTACACATTGAACCTTGCCTATATCTTTCTTCATTTAATGAGCTTATGACTGGTTTATCTAATTATTTCCACAACGCTTCAAATACACAGCAGCTCTGTAAATTCAACCATAGTGAATCTACCCAATGATAAGACACTATTGCTTTTTTTGGGAATGATAAAAATGTTGCTCATGACTTGTAGTATTCTTTCTGTAAAGCTATTCTTCACCCTTTAAAAAATTT...
pathogenic
32,556
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 43934824, gene LRPPRC (leucine rich pentatricopeptide repeat containing): what disease(s) if pathogenic?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CATGAGGAAGCTTAGAAAGGTTTAATAACTTGTCCATTATCACATAAGCAGGTAGATGGCAAAACAAGAAATCACTCTTCTGCCTCTGGCTCTATTACACCTTACTACACAAAGACAGGCACATGCATTCCTCCTGCAGAACCTCTCAGAGCTGAGCTTCATTTCCGCTCTGATCAGTGACCTGCTAATACTGACACTGTACCTACAGAGGAGCAGAACTCAATAGCCAGACAGCTCTTCTCACATTTGGATTCACTGTACTTTCAGAAGCGAATGTGGAAGAAAAATTATACCATTTTCTAGAAAATGTAAATGAACCA...
CATGAGGAAGCTTAGAAAGGTTTAATAACTTGTCCATTATCACATAAGCAGGTAGATGGCAAAACAAGAAATCACTCTTCTGCCTCTGGCTCTATTACACCTTACTACACAAAGACAGGCACATGCATTCCTCCTGCAGAACCTCTCAGAGCTGAGCTTCATTTCCGCTCTGATCAGTGACCTGCTAATACTGACACTGTACCTACAGAGGAGCAGAACTCAATAGCCAGACAGCTCTTCTCACATTTGGATTCACTGTACTTTCAGAAGCGAATGTGGAAGAAAAATTATACCATTTTCTAGAAAATGTAAATGAACCA...
pathogenic
32,562
Mutation at chromosome 2, position 43943746, within LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
GTTTTCTGTAATTTCATAAATATAAAATTTCCTTTATCTTTTTATTAGTCTCATGACTCTGAAAGAGTCAATAGCCCTTTTTATTATGATAGATGAAACTGAAAGACCTCATCATGGAGACTGCATTAGCAAAGTAGTCTAAAAAAAAAAAAAAAAAAAAACTAGGCAAATAAAAACAGAATTAAAATAAAATAAAAATAGAAGATATACATATCTGAAAGTAGTAAAACACCAATAATGAAAAGACACTAATTTAGATTTCCTTAGCTCAATTAGCAGGGAGAGCCAAATTTGACTGAGACACAGAAATATCTGACTTC...
GTTTTCTGTAATTTCATAAATATAAAATTTCCTTTATCTTTTTATTAGTCTCATGACTCTGAAAGAGTCAATAGCCCTTTTTATTATGATAGATGAAACTGAAAGACCTCATCATGGAGACTGCATTAGCAAAGTAGTCTAAAAAAAAAAAAAAAAAAAAACTAGGCAAATAAAAACAGAATTAAAATAAAATAAAAATAGAAGATATACATATCTGAAAGTAGTAAAACACCAATAATGAAAAGACACTAATTTAGATTTCCTTAGCTCAATTAGCAGGGAGAGCCAAATTTGACTGAGACACAGAAATATCTGACTTC...
pathogenic
32,567
Gene LRPPRC (leucine rich pentatricopeptide repeat containing) variant at chromosome position 43943821 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CCTTTTTATTATGATAGATGAAACTGAAAGACCTCATCATGGAGACTGCATTAGCAAAGTAGTCTAAAAAAAAAAAAAAAAAAAAACTAGGCAAATAAAAACAGAATTAAAATAAAATAAAAATAGAAGATATACATATCTGAAAGTAGTAAAACACCAATAATGAAAAGACACTAATTTAGATTTCCTTAGCTCAATTAGCAGGGAGAGCCAAATTTGACTGAGACACAGAAATATCTGACTTCAGGATATAATCAGAAGCACAGAGGATGCTCTAGGTTAACATTTGAATTCCACACCGTTTCCATTTTCCCATGGGT...
CCTTTTTATTATGATAGATGAAACTGAAAGACCTCATCATGGAGACTGCATTAGCAAAGTAGTCTAAAAAAAAAAAAAAAAAAAAACTAGGCAAATAAAAACAGAATTAAAATAAAATAAAAATAGAAGATATACATATCTGAAAGTAGTAAAACACCAATAATGAAAAGACACTAATTTAGATTTCCTTAGCTCAATTAGCAGGGAGAGCCAAATTTGACTGAGACACAGAAATATCTGACTTCAGGATATAATCAGAAGCACAGAGGATGCTCTAGGTTAACATTTGAATTCCACACCGTTTCCATTTTCCCATGGGT...
pathogenic
32,570
Is the genetic change at chromosome 2, position 43947381, within gene LRPPRC (leucine rich pentatricopeptide repeat containing) benign or pathogenic? Name the disease(s) if pathogenic.
benign
TTGGAGCTTGCCATGCTTTGCCAATACTCTTACAAGGCCTACATACTTGCCGGTGTCAAGGACAGCAGATGAATCTAAGCGGTCACTAAAAATTAAAGCCACATTTATATTGTTTTAAAAGTCAATTAACTGCTAAAAGAACAGCAACATCCATTTAATCACTTTTCAAAAGCTCATCAGAAGACCTGAACTAATGTTGGCCTCTACGCTTCAGTTAGGATTTCTTTTTGAAGCCATATACAAGTTCACACGAAATTATATTCAAAGTGACTAGTGAAGTAAAAGCCCAACACTACATATATATTGCATCACTCCATCTG...
TTGGAGCTTGCCATGCTTTGCCAATACTCTTACAAGGCCTACATACTTGCCGGTGTCAAGGACAGCAGATGAATCTAAGCGGTCACTAAAAATTAAAGCCACATTTATATTGTTTTAAAAGTCAATTAACTGCTAAAAGAACAGCAACATCCATTTAATCACTTTTCAAAAGCTCATCAGAAGACCTGAACTAATGTTGGCCTCTACGCTTCAGTTAGGATTTCTTTTTGAAGCCATATACAAGTTCACACGAAATTATATTCAAAGTGACTAGTGAAGTAAAAGCCCAACACTACATATATATTGCATCACTCCATCTG...
benign
32,588
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 43948173, gene LRPPRC (leucine rich pentatricopeptide repeat containing): what disease(s) if pathogenic?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
AAGTTCAAGGCATCTTCTACTTTATCATGTCGACAGCATAAATTTATTAAAGCTGCATAGCCACCAGTAACCATGTCGGATTCATATTTTGCTTTCAATTCAAGGGCTTTTTGCATATTCTAAAATACAGCATAGATGTGAAAAAGAAGAAATCAGTGTGAAGGTAAAAATGTCACATTTTTAGCTTTACTGTTCAGAGTTTAGAAAAAGTTAATAGTACTTTAAAAATAAATGGTTTCATGTTAACAACCTGACTCTGCCCCTTGATATTTTTATTCACCTCTAAGAAGTGGGCAAGTCTTACACGTGTAGGGGTTAAA...
AAGTTCAAGGCATCTTCTACTTTATCATGTCGACAGCATAAATTTATTAAAGCTGCATAGCCACCAGTAACCATGTCGGATTCATATTTTGCTTTCAATTCAAGGGCTTTTTGCATATTCTAAAATACAGCATAGATGTGAAAAAGAAGAAATCAGTGTGAAGGTAAAAATGTCACATTTTTAGCTTTACTGTTCAGAGTTTAGAAAAAGTTAATAGTACTTTAAAAATAAATGGTTTCATGTTAACAACCTGACTCTGCCCCTTGATATTTTTATTCACCTCTAAGAAGTGGGCAAGTCTTACACGTGTAGGGGTTAAA...
pathogenic
32,596
The chromosome 2, position 43949600 genetic variant in gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TATGCAAATTTCTTAGATATGTTGATTTTTCTGAGGTGGGGAACAGGTTTTACCAACTTCTTAGAGGTATACAAGATGATAAAAATGTGAGGAATCACTGGTTTTATAAGTACACAATCCAGAATACTCATTAAATATGGGTATTATAGCATGTAGAATCTAGTCAAAATCCTACTTACTTTTTGAAAGTCTAAATTCTTACTCTCAACCAACAAGTGAGCATCCTAAAATTGAAATTTAAATTAGCCCAGAATTAGAAAACACACGTAAAAATACATCAGCAAACATCAAAAGCAAATTTGTAAGTCTCACCTCATATT...
TATGCAAATTTCTTAGATATGTTGATTTTTCTGAGGTGGGGAACAGGTTTTACCAACTTCTTAGAGGTATACAAGATGATAAAAATGTGAGGAATCACTGGTTTTATAAGTACACAATCCAGAATACTCATTAAATATGGGTATTATAGCATGTAGAATCTAGTCAAAATCCTACTTACTTTTTGAAAGTCTAAATTCTTACTCTCAACCAACAAGTGAGCATCCTAAAATTGAAATTTAAATTAGCCCAGAATTAGAAAACACACGTAAAAATACATCAGCAAACATCAAAAGCAAATTTGTAAGTCTCACCTCATATT...
pathogenic
32,601
Regarding the variant at chromosome 2 and position 43949613, affecting gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TAGATATGTTGATTTTTCTGAGGTGGGGAACAGGTTTTACCAACTTCTTAGAGGTATACAAGATGATAAAAATGTGAGGAATCACTGGTTTTATAAGTACACAATCCAGAATACTCATTAAATATGGGTATTATAGCATGTAGAATCTAGTCAAAATCCTACTTACTTTTTGAAAGTCTAAATTCTTACTCTCAACCAACAAGTGAGCATCCTAAAATTGAAATTTAAATTAGCCCAGAATTAGAAAACACACGTAAAAATACATCAGCAAACATCAAAAGCAAATTTGTAAGTCTCACCTCATATTACTACTTTTCATC...
TAGATATGTTGATTTTTCTGAGGTGGGGAACAGGTTTTACCAACTTCTTAGAGGTATACAAGATGATAAAAATGTGAGGAATCACTGGTTTTATAAGTACACAATCCAGAATACTCATTAAATATGGGTATTATAGCATGTAGAATCTAGTCAAAATCCTACTTACTTTTTGAAAGTCTAAATTCTTACTCTCAACCAACAAGTGAGCATCCTAAAATTGAAATTTAAATTAGCCCAGAATTAGAAAACACACGTAAAAATACATCAGCAAACATCAAAAGCAAATTTGTAAGTCTCACCTCATATTACTACTTTTCATC...
pathogenic
32,602
Does the chromosome 2 mutation at position 43960605 within gene LRPPRC (leucine rich pentatricopeptide repeat containing) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
AAAAGTCACTTTTAAAATGACCTGCACTGAGTCACTCAAGGAATTTTAAAGGGAACACCACCACATGCCTCTCAGCAGCTTTTAATTTCATGTGATCAAATTAGTTTTCCATGCCTACAAACACAAGTGGGAAAATGTTCTCTACTACTCCAAAACTTAATCAAGATAATCCATTTACTGTTCTCTACTACCTGACATTTCCTGTGATGTAGTAACCAGTAGTGCATTCCTAAGAGCTGCCTGAAGCACGTACCAGCAATCATAGAACGAACCGCTCTTCAAAGACTTGTAAATCAAAGCTGGAGGGGAAGGCACTGACA...
AAAAGTCACTTTTAAAATGACCTGCACTGAGTCACTCAAGGAATTTTAAAGGGAACACCACCACATGCCTCTCAGCAGCTTTTAATTTCATGTGATCAAATTAGTTTTCCATGCCTACAAACACAAGTGGGAAAATGTTCTCTACTACTCCAAAACTTAATCAAGATAATCCATTTACTGTTCTCTACTACCTGACATTTCCTGTGATGTAGTAACCAGTAGTGCATTCCTAAGAGCTGCCTGAAGCACGTACCAGCAATCATAGAACGAACCGCTCTTCAAAGACTTGTAAATCAAAGCTGGAGGGGAAGGCACTGACA...
pathogenic
32,618
A mutation at chromosome position 43973614 on chromosome 2 in gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TTGAAAACTCTTGGTTCCACTTTGTCTGATCCCCAAATATCTTTGATTTTCTGAAGAGATGTATTTATTCCTCATGAAACACAGCACATCCTCCATCACTGCAGTCACTTTCTTCTGTGATTTCTACCATTTTATACGTGACTTTCACTGGACAAAGAACAAGTTCATTGCACTAATAAGAATGTTACTTTCTTACCTTACACTAAAGAAACTATAAAGAATACATACAGCCATTTCTCTGTTATATAAAAGAAGACTGTAGAATATATACTTTACTATCTTTCAGGACCTACTGCAAAGAAGAATATATTGTTTTTAAA...
TTGAAAACTCTTGGTTCCACTTTGTCTGATCCCCAAATATCTTTGATTTTCTGAAGAGATGTATTTATTCCTCATGAAACACAGCACATCCTCCATCACTGCAGTCACTTTCTTCTGTGATTTCTACCATTTTATACGTGACTTTCACTGGACAAAGAACAAGTTCATTGCACTAATAAGAATGTTACTTTCTTACCTTACACTAAAGAAACTATAAAGAATACATACAGCCATTTCTCTGTTATATAAAAGAAGACTGTAGAATATATACTTTACTATCTTTCAGGACCTACTGCAAAGAAGAATATATTGTTTTTAAA...
pathogenic
32,629
Clinically, how would you classify the variant at chromosome 2, position 43973860, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
TAAAAGAAGACTGTAGAATATATACTTTACTATCTTTCAGGACCTACTGCAAAGAAGAATATATTGTTTTTAAAAATTGTAAAACTGACAATCTTTTGCACTCTCAGAACACACAATATAAAAGCATAAACTTTTATATTTTTTCAGACAAAACCTTCATCGATTAAAAAATTCACTCTCTTTTAGCAATGTTATTCGTGTAAAAACTGGCAACTAATTTTTAAACAGCAGCTAAGAATTTTTAGAAAATAAACACAGTATAGTACTTACAAAAGCTGAATATGGAAGGGTTATAGTATAAAAAAGGATATTTTAAAAGG...
TAAAAGAAGACTGTAGAATATATACTTTACTATCTTTCAGGACCTACTGCAAAGAAGAATATATTGTTTTTAAAAATTGTAAAACTGACAATCTTTTGCACTCTCAGAACACACAATATAAAAGCATAAACTTTTATATTTTTTCAGACAAAACCTTCATCGATTAAAAAATTCACTCTCTTTTAGCAATGTTATTCGTGTAAAAACTGGCAACTAATTTTTAAACAGCAGCTAAGAATTTTTAGAAAATAAACACAGTATAGTACTTACAAAAGCTGAATATGGAAGGGTTATAGTATAAAAAAGGATATTTTAAAAGG...
pathogenic
32,632
Chromosome 2, position 43974209, gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
CCTAATCACACCTAGACGTGGAAGCTAAGGTCAGTCACTGAATGTCTGTGTGGCCCTCAGTTCCTTCATTCACGTAATGTGAGCTTTCAGTACAGCACTTTTAAAATCTAAATTCTGAGATTCTAAGACAAGATGGATTTGAGATAAAGCCCATTTTCTACTATTTCAACTGCTACAACCATAGAAAGAAATTACCTAACTCTTTTATGTTTACTAAGTAGTAAAAATGTAGTAATCAATTCAACTGTGACATGGTTGTGGAAAGCAGATTAACCTGATGAACAAACATTTCAACTGGTACCAAAAAAATTTTCATACTT...
CCTAATCACACCTAGACGTGGAAGCTAAGGTCAGTCACTGAATGTCTGTGTGGCCCTCAGTTCCTTCATTCACGTAATGTGAGCTTTCAGTACAGCACTTTTAAAATCTAAATTCTGAGATTCTAAGACAAGATGGATTTGAGATAAAGCCCATTTTCTACTATTTCAACTGCTACAACCATAGAAAGAAATTACCTAACTCTTTTATGTTTACTAAGTAGTAAAAATGTAGTAATCAATTCAACTGTGACATGGTTGTGGAAAGCAGATTAACCTGATGAACAAACATTTCAACTGGTACCAAAAAAATTTTCATACTT...
pathogenic
32,634
Variant in LRPPRC (leucine rich pentatricopeptide repeat containing), chromosome 2, position 43982329—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
ATAAAGGGCCAGGCGCGAATCCCAGTACTTTGGGAGGTTGAGGCAGGCAGATCACCTGAGGTCGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATATAAAATTAGCTGGGCGAGATGGCGCATGCCTGTAATTCTAGCTACTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGTGGAGGCTGCGGTGAGCCGACATTGCACCACTGCACTCCAGCCTAGACAACAAGATCAAGACTCTGTTTCAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAGAGAGAGAGAGAGAG...
ATAAAGGGCCAGGCGCGAATCCCAGTACTTTGGGAGGTTGAGGCAGGCAGATCACCTGAGGTCGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATATAAAATTAGCTGGGCGAGATGGCGCATGCCTGTAATTCTAGCTACTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGTGGAGGCTGCGGTGAGCCGACATTGCACCACTGCACTCCAGCCTAGACAACAAGATCAAGACTCTGTTTCAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAGAGAGAGAGAGAGAG...
pathogenic
32,659
A genetic variant on chromosome 2, position 43982452, affects the gene LRPPRC (leucine rich pentatricopeptide repeat containing). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
TTAGCTGGGCGAGATGGCGCATGCCTGTAATTCTAGCTACTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGTGGAGGCTGCGGTGAGCCGACATTGCACCACTGCACTCCAGCCTAGACAACAAGATCAAGACTCTGTTTCAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAGAGAGAGAGAGAGAGAAAGAAAGAATACTGTAAAGCAGTGTAATTAACATCTATGAATAGAAAAGTTAGGTTCATAATCAGCTACAATATAAGCTTCCCTCTCCCTATATCTGTAAGCTTTATCTACATATCCCTGAA...
TTAGCTGGGCGAGATGGCGCATGCCTGTAATTCTAGCTACTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGTGGAGGCTGCGGTGAGCCGACATTGCACCACTGCACTCCAGCCTAGACAACAAGATCAAGACTCTGTTTCAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAGAGAGAGAGAGAGAGAAAGAAAGAATACTGTAAAGCAGTGTAATTAACATCTATGAATAGAAAAGTTAGGTTCATAATCAGCTACAATATAAGCTTCCCTCTCCCTATATCTGTAAGCTTTATCTACATATCCCTGAA...
benign
32,663
Evaluate the clinical significance of the mutation at chromosome 2, position 43995824 in gene LRPPRC (leucine rich pentatricopeptide repeat containing): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Congenital_lactic_acidosis,_Saguenay-Lac-Saint-Jean_type']
GACAAGTGAGGTGTGCCACGAATAAATCTACAGTGGGACCGGCATGTTTTGGATTGAGTGTTGAGGTAAGGCTTCCCTGAAGAGACATTTGAGATCTGAATGATAAGAAAGCAACTTTACAAAGATAAGGGGGAAAGGCCTTTACAGATAATGAAACTGAGGAACAGACAGGTTAGTAAGATGGCTGAGATTACGCAGTAAGTAAACAGAACCCAGGTCTGATGAACACCGAGACCACCCTTTCTACTAAACTATGTTCTCTCTTTATTCAGTTCTCCTCAAATGCAACAGTGAAGATAAAAGAAAATGTGGACCTTCCC...
GACAAGTGAGGTGTGCCACGAATAAATCTACAGTGGGACCGGCATGTTTTGGATTGAGTGTTGAGGTAAGGCTTCCCTGAAGAGACATTTGAGATCTGAATGATAAGAAAGCAACTTTACAAAGATAAGGGGGAAAGGCCTTTACAGATAATGAAACTGAGGAACAGACAGGTTAGTAAGATGGCTGAGATTACGCAGTAAGTAAACAGAACCCAGGTCTGATGAACACCGAGACCACCCTTTCTACTAAACTATGTTCTCTCTTTATTCAGTTCTCCTCAAATGCAACAGTGAAGATAAAAGAAAATGTGGACCTTCCC...
pathogenic
32,670
Does the genetic variant at chromosome 2, position 44275695, impacting gene SLC3A1 (solute carrier family 3 member 1), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Cystinuria']
TTTTTCTTATACCTGGCTAAATAGAGAAAGCTTTAAGCTTTAAAAAAAGTTGTGGTAAAACATCTGTAACATTTCAGTGGCATTACGTATGTTTATACTGTTATGCAACCATCACCACTATCATCTCAGGAATACTTTTCATCATCCCAAACTGAAATTCTCTGCCCAATGAACAATAACTCCCCATTATTCCCTTCCTCCAACCTCCAGTAACCACGTTTCTATTTTCTGTTCCTATGAATCCTACTACTCAAGATACCTCATCTAAGTGAAATCACACTTGCCCTTTTGGGTCTGGCTTATTGCACTTAGCATAATGT...
TTTTTCTTATACCTGGCTAAATAGAGAAAGCTTTAAGCTTTAAAAAAAGTTGTGGTAAAACATCTGTAACATTTCAGTGGCATTACGTATGTTTATACTGTTATGCAACCATCACCACTATCATCTCAGGAATACTTTTCATCATCCCAAACTGAAATTCTCTGCCCAATGAACAATAACTCCCCATTATTCCCTTCCTCCAACCTCCAGTAACCACGTTTCTATTTTCTGTTCCTATGAATCCTACTACTCAAGATACCTCATCTAAGTGAAATCACACTTGCCCTTTTGGGTCTGGCTTATTGCACTTAGCATAATGT...
pathogenic
32,678
Gene mutation in SLC3A1 (solute carrier family 3 member 1) at chromosome 2, position 44280876—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Cystinuria', 'Nephrocalcinosis', 'Nephrolithiasis']
GTCCAAATTTAGCAAGTTCAAAGGCAGTCTGAGAGTGGAAACAAAGACTCCTCAAATATTGGCACAAACTTACCTTCTGTGTTGAGGTTGCACTCCTTCTCAGACCCCGTGCACTGACAACATTTATCACCTTTTTAAATTAATTGATGCATTTACTTATTTATTTATATTTATTATTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCTAGGCTGGAGTGCAGTGGCACAATCTCACCTCACTACAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGC...
GTCCAAATTTAGCAAGTTCAAAGGCAGTCTGAGAGTGGAAACAAAGACTCCTCAAATATTGGCACAAACTTACCTTCTGTGTTGAGGTTGCACTCCTTCTCAGACCCCGTGCACTGACAACATTTATCACCTTTTTAAATTAATTGATGCATTTACTTATTTATTTATATTTATTATTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCTAGGCTGGAGTGCAGTGGCACAATCTCACCTCACTACAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGAATGC...
pathogenic
32,681
Mutation at chromosome 2, position 44301128, within SLC3A1 (solute carrier family 3 member 1): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
CCAGGCTGGAGTGCAATGGCCCAATCTCGGCTCACCACAACTTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTCGGCCTCCCGAGTAGCTGGGATTATGGGCACCCGCCACCATGCCTGGCTACTTTTTGTATTTTTAGTAGAGACAGGGTTTCATCATGTTGGCCAGGCTGGTGTCAAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCCATTTCATCTTTTATTATCTGAGTGTATTCAAGACAACACTAGTATCTGAGTTTTACCACA...
CCAGGCTGGAGTGCAATGGCCCAATCTCGGCTCACCACAACTTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTCGGCCTCCCGAGTAGCTGGGATTATGGGCACCCGCCACCATGCCTGGCTACTTTTTGTATTTTTAGTAGAGACAGGGTTTCATCATGTTGGCCAGGCTGGTGTCAAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCCATTTCATCTTTTATTATCTGAGTGTATTCAAGACAACACTAGTATCTGAGTTTTACCACA...
benign
32,698
Is the genetic variant on chromosome 2, position 44304311, gene SLC3A1 (solute carrier family 3 member 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Cystinuria']
CATCAATAAAAAAGTGATAGCAATAACCTCTATAAGGCTGTTGTGAGATTAAATTAGATAATGTATATAAAGTAGTGCCTGGATCATAGTAAACACTCAATAAAATTACCCATCATTAAGTTTACATAGATCACTCAACAGAATCAATAGGAAGGAATTAAAGAAATTTCATCTCCTTAAAGTAGGTACTCCGATTACTCTGTCTCCATTTTATAGACAAGGAAACTGAGGCTCTGAGCATGTAAGTAATGTCCACAGGTAGGAGTGGCAGCTATGGGATTTGAACTGAAGCAGTTGGGCTCCAGAGACCATGCACTTAT...
CATCAATAAAAAAGTGATAGCAATAACCTCTATAAGGCTGTTGTGAGATTAAATTAGATAATGTATATAAAGTAGTGCCTGGATCATAGTAAACACTCAATAAAATTACCCATCATTAAGTTTACATAGATCACTCAACAGAATCAATAGGAAGGAATTAAAGAAATTTCATCTCCTTAAAGTAGGTACTCCGATTACTCTGTCTCCATTTTATAGACAAGGAAACTGAGGCTCTGAGCATGTAAGTAATGTCCACAGGTAGGAGTGGCAGCTATGGGATTTGAACTGAAGCAGTTGGGCTCCAGAGACCATGCACTTAT...
pathogenic
32,703
Is the genetic mutation found on chromosome 2 at position 44313933, within the gene SLC3A1 (solute carrier family 3 member 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cystinuria']
CTAGCACTGTTGTGTGAAGGAGGGAAATATAGGTGTGAAAGTACTTTTTAAAAAGTAAAGTGCCATGCTCAGCGTATGCACATGAGGGTTTGAGTTGTGGGTTATGGAGAGAGTTGTCAGGTGATTTAAATAAATTCTTATTTAAACAAACTTATTTAAATAAGGGCTAGAATATACCTAGAACGTTTAACATGGAAATATATTTACAAATAGAAAACACTTTATAAAATTTCATCTTGGAGTATGTAAATTCTTTCTAAAAGTTGATTTACTTTAAAAATTTTGTCTGAATAATTCATAAGTCAAAACAATTTTTTAAA...
CTAGCACTGTTGTGTGAAGGAGGGAAATATAGGTGTGAAAGTACTTTTTAAAAAGTAAAGTGCCATGCTCAGCGTATGCACATGAGGGTTTGAGTTGTGGGTTATGGAGAGAGTTGTCAGGTGATTTAAATAAATTCTTATTTAAACAAACTTATTTAAATAAGGGCTAGAATATACCTAGAACGTTTAACATGGAAATATATTTACAAATAGAAAACACTTTATAAAATTTCATCTTGGAGTATGTAAATTCTTTCTAAAAGTTGATTTACTTTAAAAATTTTGTCTGAATAATTCATAAGTCAAAACAATTTTTTAAA...
pathogenic
32,713
Does the genetic variant at chromosome 2, position 44313951, impacting gene SLC3A1 (solute carrier family 3 member 1), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Cystinuria']
GGAGGGAAATATAGGTGTGAAAGTACTTTTTAAAAAGTAAAGTGCCATGCTCAGCGTATGCACATGAGGGTTTGAGTTGTGGGTTATGGAGAGAGTTGTCAGGTGATTTAAATAAATTCTTATTTAAACAAACTTATTTAAATAAGGGCTAGAATATACCTAGAACGTTTAACATGGAAATATATTTACAAATAGAAAACACTTTATAAAATTTCATCTTGGAGTATGTAAATTCTTTCTAAAAGTTGATTTACTTTAAAAATTTTGTCTGAATAATTCATAAGTCAAAACAATTTTTTAAAAGAGGACACATCAGAAGT...
GGAGGGAAATATAGGTGTGAAAGTACTTTTTAAAAAGTAAAGTGCCATGCTCAGCGTATGCACATGAGGGTTTGAGTTGTGGGTTATGGAGAGAGTTGTCAGGTGATTTAAATAAATTCTTATTTAAACAAACTTATTTAAATAAGGGCTAGAATATACCTAGAACGTTTAACATGGAAATATATTTACAAATAGAAAACACTTTATAAAATTTCATCTTGGAGTATGTAAATTCTTTCTAAAAGTTGATTTACTTTAAAAATTTTGTCTGAATAATTCATAAGTCAAAACAATTTTTTAAAAGAGGACACATCAGAAGT...
pathogenic
32,714
Determine whether the variant at chromosome 2, position 44320279, in gene SLC3A1 is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Cystinuria']
CAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTAT...
CAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTAT...
pathogenic
32,720
Evaluate this variant at chromosome 2, position 44320329, gene SLC3A1: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Cystinuria', 'SLC3A1-related_disorder']
GGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACATATG...
GGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACATATG...
pathogenic
32,721
Variant at chromosome 2, position 44320600, gene SLC3A1: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Cystinuria']
GAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAAAAATAAAATTACAAAAATCAGGCTTGGAAGTATTTAATAGCAGACAAAATATAGTTCAATATGAAAAGCATTATATGAGACAAAGGCAATTTTCAAAAATTGATAAAACATTCCACCAAAAATCAT...
GAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAAAAATAAAATTACAAAAATCAGGCTTGGAAGTATTTAATAGCAGACAAAATATAGTTCAATATGAAAAGCATTATATGAGACAAAGGCAATTTTCAAAAATTGATAAAACATTCCACCAAAAATCAT...
pathogenic
32,724
Evaluate this variant at chromosome 2, position 44332526, gene PREPL (prolyl endopeptidase like): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Myasthenic_syndrome,_congenital,_22']
AATACACTAAGTGGGTAACAATGATTATTTCTAAGAGGTGCAGCAAGCAAATGGTACTGAGAAGTAGTCATTTAAGATTTGTTCTGTATTTTTGCATCTGTTCAACAAGCATGTATTGCTTTTGTAATATAAAAATATTAATATTTACTTAAAGATTGTCAGAGAAAAATAAATGAATTAAAGAAAAAAATTCCTAAGAATAAAAGGCTTGTGTTGTAATTCATTGTGTCAGCACATGTGAAATTATCTGATATATGATATGCTAAAGTCTGAGGTTTCCTTAAATTCAAGGCTATAGTTTACATATTAATTTGTTCCCT...
AATACACTAAGTGGGTAACAATGATTATTTCTAAGAGGTGCAGCAAGCAAATGGTACTGAGAAGTAGTCATTTAAGATTTGTTCTGTATTTTTGCATCTGTTCAACAAGCATGTATTGCTTTTGTAATATAAAAATATTAATATTTACTTAAAGATTGTCAGAGAAAAATAAATGAATTAAAGAAAAAAATTCCTAAGAATAAAAGGCTTGTGTTGTAATTCATTGTGTCAGCACATGTGAAATTATCTGATATATGATATGCTAAAGTCTGAGGTTTCCTTAAATTCAAGGCTATAGTTTACATATTAATTTGTTCCCT...
pathogenic
32,747
A genetic variant on chromosome 2, position 44332563, affects the gene PREPL (prolyl endopeptidase like). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Myasthenic_syndrome,_congenital,_22']
GTGCAGCAAGCAAATGGTACTGAGAAGTAGTCATTTAAGATTTGTTCTGTATTTTTGCATCTGTTCAACAAGCATGTATTGCTTTTGTAATATAAAAATATTAATATTTACTTAAAGATTGTCAGAGAAAAATAAATGAATTAAAGAAAAAAATTCCTAAGAATAAAAGGCTTGTGTTGTAATTCATTGTGTCAGCACATGTGAAATTATCTGATATATGATATGCTAAAGTCTGAGGTTTCCTTAAATTCAAGGCTATAGTTTACATATTAATTTGTTCCCTACTTGCATAAATTTGTATATTCTGTATATTGAGTATA...
GTGCAGCAAGCAAATGGTACTGAGAAGTAGTCATTTAAGATTTGTTCTGTATTTTTGCATCTGTTCAACAAGCATGTATTGCTTTTGTAATATAAAAATATTAATATTTACTTAAAGATTGTCAGAGAAAAATAAATGAATTAAAGAAAAAAATTCCTAAGAATAAAAGGCTTGTGTTGTAATTCATTGTGTCAGCACATGTGAAATTATCTGATATATGATATGCTAAAGTCTGAGGTTTCCTTAAATTCAAGGCTATAGTTTACATATTAATTTGTTCCCTACTTGCATAAATTTGTATATTCTGTATATTGAGTATA...
pathogenic
32,748
Chromosome 2, position 44339365, gene PREPL (prolyl endopeptidase like): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
CCCCACAGCACATTTTATGTTTTTGATACTACTTATTCAAATCCATGATACACTTAACCTTTATGTACTAGTTTAATCTTGTGATTAACTATATCTTCCTTAAGGCTAGGATATTCTGCTTTAACAGCTTTCGATTCTATAATGCCCGATACAGTATTGTGCACATGAAAGTTCAATAAAAAGCCACTGAATTGACTGAAATTGCATTTTTACAGGAGTTTTAAGAATATTGGAGTTAGGGAGGTATAAATGGTCTATGCTGTTTGCTCATCAACTGGCTCAGTAACTCTTTTCATATCAAACAAAATGGAAGCCATCCT...
CCCCACAGCACATTTTATGTTTTTGATACTACTTATTCAAATCCATGATACACTTAACCTTTATGTACTAGTTTAATCTTGTGATTAACTATATCTTCCTTAAGGCTAGGATATTCTGCTTTAACAGCTTTCGATTCTATAATGCCCGATACAGTATTGTGCACATGAAAGTTCAATAAAAAGCCACTGAATTGACTGAAATTGCATTTTTACAGGAGTTTTAAGAATATTGGAGTTAGGGAGGTATAAATGGTCTATGCTGTTTGCTCATCAACTGGCTCAGTAACTCTTTTCATATCAAACAAAATGGAAGCCATCCT...
benign
32,754
Variant at chromosome position 44342561, chromosome 2, gene PREPL (prolyl endopeptidase like): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
CTTCTGTATTGGATCACATTACCATGTTTATTTGTCAATCGTTATTTCTTTTGTGAAATGTGTGTCTATTTTAAACTTTGAATGTAGCTTAAATTATTAGTATGTAAATAGCTCTTTAAAAATTAAGAATATTGGCTGGGCACAGTGGCTCACAACTGTAATCCCAGCACTCTGGGAGGCCAAAGCTGGCAGATCACCTGAGATCAGGAGTTCAAGACCACCCTGGCCAACATGGTGAAACCCCGTCTCCACAAAAAATACAAAAATTAGCCAGGCATGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGG...
CTTCTGTATTGGATCACATTACCATGTTTATTTGTCAATCGTTATTTCTTTTGTGAAATGTGTGTCTATTTTAAACTTTGAATGTAGCTTAAATTATTAGTATGTAAATAGCTCTTTAAAAATTAAGAATATTGGCTGGGCACAGTGGCTCACAACTGTAATCCCAGCACTCTGGGAGGCCAAAGCTGGCAGATCACCTGAGATCAGGAGTTCAAGACCACCCTGGCCAACATGGTGAAACCCCGTCTCCACAAAAAATACAAAAATTAGCCAGGCATGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGG...
benign
32,756
Is the genetic variant on chromosome 2, position 44343926, gene PREPL (prolyl endopeptidase like), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Myasthenic_syndrome,_congenital,_22', 'PREPL-related_disorder']
AGTTAGTTTTAATTTATAATTTAGTAGCAACACATACTTTAAATTCTTCTATATATTACTAAGAATTTAATGGTTAAAAGGTACTCAACAATCATCAGGAACAAGGGGTTTTAGTTTGAAAGAGAGATACCTATCTAAGTATATACCATTTATTTAAGCAATAGATACTGACTAAATAGCACTATACAAACCTGGCACCCTGCTTATCAATTAAGATGCAAAGGTGAAACAGACTCAGTCTGTTCACAATCTAGCAGTTCTAGGTCATCTTTATGAATTTACATGAATGAACTATGTTGTAATTCACAAAATCAATTTCA...
AGTTAGTTTTAATTTATAATTTAGTAGCAACACATACTTTAAATTCTTCTATATATTACTAAGAATTTAATGGTTAAAAGGTACTCAACAATCATCAGGAACAAGGGGTTTTAGTTTGAAAGAGAGATACCTATCTAAGTATATACCATTTATTTAAGCAATAGATACTGACTAAATAGCACTATACAAACCTGGCACCCTGCTTATCAATTAAGATGCAAAGGTGAAACAGACTCAGTCTGTTCACAATCTAGCAGTTCTAGGTCATCTTTATGAATTTACATGAATGAACTATGTTGTAATTCACAAAATCAATTTCA...
pathogenic
32,760
Classify the chromosome 2 variant at position 44346383 affecting gene PREPL (prolyl endopeptidase like) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Myasthenic_syndrome,_congenital,_22']
TGCCAAAGCTTCTGAGTCTAACTATATCTTACACAAACCCAGATATTAAAAACTAGTCATTAAAAAAAAATTCAGAAATAATCTTTAAAAAAATCTTTTCTCTATCTTTGAGAAATTAATAAATTTCCTATAAAAAATATGAAATCTGAAAATTAGAGCACGTAAAAAGAAAAATTGTGGTGTACCTTCTTCATCTTTGGAACGAACCAAGCAACAACCTTCTTGGTAATAAACAAAACCACCATGTTTAACCTGACAAAAGAAACATGCAGTTTACTTAATAATAATTTAATTAACCTTTTCATAGTCTGACTATTCAA...
TGCCAAAGCTTCTGAGTCTAACTATATCTTACACAAACCCAGATATTAAAAACTAGTCATTAAAAAAAAATTCAGAAATAATCTTTAAAAAAATCTTTTCTCTATCTTTGAGAAATTAATAAATTTCCTATAAAAAATATGAAATCTGAAAATTAGAGCACGTAAAAAGAAAAATTGTGGTGTACCTTCTTCATCTTTGGAACGAACCAAGCAACAACCTTCTTGGTAATAAACAAAACCACCATGTTTAACCTGACAAAAGAAACATGCAGTTTACTTAATAATAATTTAATTAACCTTTTCATAGTCTGACTATTCAA...
pathogenic
32,765
Is the variant located on chromosome 2 at position 44942123, gene SIX3 (SIX homeobox 3), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Holoprosencephaly_2']
TCGGAATGCAGAAAAGATCTTTAAAAAAAAAAAAAAAAAGTTTTGAATTCCTCAATGATTTTTCTTCTGGAAAGGCAGCTTAGGATAATTATTTCAGCTTTATTGAGGGCAGATTAGTTGAAGTCTGGGCGCTGCGTTTCAATACGCGTTGTACACGGGCCGACAATGTGGTCATTGTTGGCTACTGTGTGTGAATCCATTCAACATATACACTTTTTAACACCAAACCGAGTCCTGTCTAAATATACACAGTGCTCAGGGAAAGACGTCTCTGACCCCGACAAATCTGCGTAAATCACACTTCCATAGTTACAGAAGCC...
TCGGAATGCAGAAAAGATCTTTAAAAAAAAAAAAAAAAAGTTTTGAATTCCTCAATGATTTTTCTTCTGGAAAGGCAGCTTAGGATAATTATTTCAGCTTTATTGAGGGCAGATTAGTTGAAGTCTGGGCGCTGCGTTTCAATACGCGTTGTACACGGGCCGACAATGTGGTCATTGTTGGCTACTGTGTGTGAATCCATTCAACATATACACTTTTTAACACCAAACCGAGTCCTGTCTAAATATACACAGTGCTCAGGGAAAGACGTCTCTGACCCCGACAAATCTGCGTAAATCACACTTCCATAGTTACAGAAGCC...
pathogenic
32,775
Variant in gene SIX3 (SIX homeobox 3), located at chromosome 2 position 44942499: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Holoprosencephaly_2']
CTAAGAATAAATACCCATGCCTGGCCTAGGGGCTGTGGTGGCCAGAGGCAGAGAGGGCCCTCTGTGTTCTATGGGCCTTTTGGCGTCTGTTTTAGGCTTTCGATGTTACTTTCCCTAGAGAAATTAGACAGTTTAAAAATAATAATGGTAATTATTATTATTTTACAATACGAGCAAACAAGCAATTTTCAGGCCTTATTCACTTCATCCGGGTGGCTGGCCTCCAAAGTTTGAGTGCCCTCTGGGGCTGGCAGGCAGGACCAGAGCTCCTTCTGTTGTGTGGTGAGGAGTGGGCATCTGTAGGACTTTTCTGGGTCCAG...
CTAAGAATAAATACCCATGCCTGGCCTAGGGGCTGTGGTGGCCAGAGGCAGAGAGGGCCCTCTGTGTTCTATGGGCCTTTTGGCGTCTGTTTTAGGCTTTCGATGTTACTTTCCCTAGAGAAATTAGACAGTTTAAAAATAATAATGGTAATTATTATTATTTTACAATACGAGCAAACAAGCAATTTTCAGGCCTTATTCACTTCATCCGGGTGGCTGGCCTCCAAAGTTTGAGTGCCCTCTGGGGCTGGCAGGCAGGACCAGAGCTCCTTCTGTTGTGTGGTGAGGAGTGGGCATCTGTAGGACTTTTCTGGGTCCAG...
pathogenic
32,783