question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Gene TBC1D24 (TBC1 domain family member 24) variant at chromosome position 2500824 on chromosome 16: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_65', 'Caused_by_mutation_in_the_TBC1_domain_family,_member_24', 'Developmental_and_epileptic_encephalopathy,_1']
TGCTGCCAGGTGCAGCCAGGGAGCCTCCCTCCAGCCTTGGACAGCATGTGGCCGTGGGAGCTCTGGGTTGGGCCTGGGGTGACCTGGGGGTGAGGCAGGCAGAGCTGGTCCAGCCCCCACCCAGCACCGTTCACAGGTTCATAACAACTCAAGCATTTTGGCACAGCTGGAGCCACTTCTCCTGGCCCTGCCAAGGACACCAGCCAAGCTCCAGGCGCCACGTTGGCAGACCAGGGCCTCTTTGGCTCCCACATGCCTGGGCTGCGAGGATGGCCCAAACCTCCCCACCGCAGGGACCTGTTCCTCTGGTTCCTGCTTCC...
TGCTGCCAGGTGCAGCCAGGGAGCCTCCCTCCAGCCTTGGACAGCATGTGGCCGTGGGAGCTCTGGGTTGGGCCTGGGGTGACCTGGGGGTGAGGCAGGCAGAGCTGGTCCAGCCCCCACCCAGCACCGTTCACAGGTTCATAACAACTCAAGCATTTTGGCACAGCTGGAGCCACTTCTCCTGGCCCTGCCAAGGACACCAGCCAAGCTCCAGGCGCCACGTTGGCAGACCAGGGCCTCTTTGGCTCCCACATGCCTGGGCTGCGAGGATGGCCCAAACCTCCCCACCGCAGGGACCTGTTCCTCTGGTTCCTGCTTCC...
pathogenic
245,418
Does the variant impacting SRRM2 (serine/arginine repetitive matrix 2) on chromosome 16, position 2759621, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
GGCCAGCGTGAGTGTTGCGCTCTCCCTCGATGACTCTGGACTCTACTCTGGCTGCTGGCTGCTGCTGCTGTCCTTTTCCTTACGTGGGACTTCCTCCCTGCTTTCGTCTGCCTTTCCCATGCCTTATTTGGCTCCTGCTTATACTTGTGTTCTGAATATGGCTCTGTCCTTTATATTTCCTTCAGACTTTTGCCCTTCTTTTCTCTAGGGTCACGGAGACTCACCAGTTGGCAGAATTAAATGAGAAGAAGAATGAAAGACTCCGTGCTGCCTTTGGCATCAGTGATTCTTACGTAGATGGCAGCTCTTTTGATCCTCAG...
GGCCAGCGTGAGTGTTGCGCTCTCCCTCGATGACTCTGGACTCTACTCTGGCTGCTGGCTGCTGCTGCTGTCCTTTTCCTTACGTGGGACTTCCTCCCTGCTTTCGTCTGCCTTTCCCATGCCTTATTTGGCTCCTGCTTATACTTGTGTTCTGAATATGGCTCTGTCCTTTATATTTCCTTCAGACTTTTGCCCTTCTTTTCTCTAGGGTCACGGAGACTCACCAGTTGGCAGAATTAAATGAGAAGAAGAATGAAAGACTCCGTGCTGCCTTTGGCATCAGTGATTCTTACGTAGATGGCAGCTCTTTTGATCCTCAG...
benign
245,434
Is the variant located on chromosome 16 at position 2769117, gene SRRM2 (serine/arginine repetitive matrix 2), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
ATTGCACTTGCCCTGACAGCTATCAGTCTTGGCACCGCTCGGCCTCCTCCGTCCATGTCTGCTGCTGGCCTTGCTGCAAGAATGTCCCAGGTTCCAGCCCCGGTGCCTCTCATGAGTCTCAGAACCGCACCAGCAGCCAACCTTGCCAGCAGGATTCCTGCAGCCTCTGCGGCAGCCATGAACCTAGCCAGCGCCAGGACACCTGCCATTCCAACAGCAGTGAACCTGGCTGACTCTCGAACGCCAGCTGCAGCAGCGGCCATGAACTTGGCCAGCCCCAGAACAGCGGTGGCACCTTCGGCTGTGAACCTGGCTGACCC...
ATTGCACTTGCCCTGACAGCTATCAGTCTTGGCACCGCTCGGCCTCCTCCGTCCATGTCTGCTGCTGGCCTTGCTGCAAGAATGTCCCAGGTTCCAGCCCCGGTGCCTCTCATGAGTCTCAGAACCGCACCAGCAGCCAACCTTGCCAGCAGGATTCCTGCAGCCTCTGCGGCAGCCATGAACCTAGCCAGCGCCAGGACACCTGCCATTCCAACAGCAGTGAACCTGGCTGACTCTCGAACGCCAGCTGCAGCAGCGGCCATGAACTTGGCCAGCCCCAGAACAGCGGTGGCACCTTCGGCTGTGAACCTGGCTGACCC...
benign
245,462
A genetic variant on chromosome 16, position 3026268, affects the gene THOC6 (THO complex subunit 6). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['THOC6-related_disorder']
TTCGCGCCGAAGGCGGTAGGGCGCCACGGAGAGGAACCGCTCTAGGCACGTAAGGCCTCGTGAGGTTGCGTCGCGCGCGGAGCACTCTGGGACTTGTAGTTCTGGAGATGGAGCGAGCTGTGCCGCTCGCGGTGCCTCTGGGTCAGGTGAGACGGACGTGGTGCGCGTTGCCTTCTGGGGTTTGTAGTTCACGCATGGCTGGGACGGGGCGGGCAGGGAATCGTGCCCTGAGCCCTGTTTTGCCTGGGCTATTTGTGGGACTCAGACTCTGACCAGGGGGGCGGGATAGTAACCCAGAAGTGCTTCAGGGGCTTAACGCA...
TTCGCGCCGAAGGCGGTAGGGCGCCACGGAGAGGAACCGCTCTAGGCACGTAAGGCCTCGTGAGGTTGCGTCGCGCGCGGAGCACTCTGGGACTTGTAGTTCTGGAGATGGAGCGAGCTGTGCCGCTCGCGGTGCCTCTGGGTCAGGTGAGACGGACGTGGTGCGCGTTGCCTTCTGGGGTTTGTAGTTCACGCATGGCTGGGACGGGGCGGGCAGGGAATCGTGCCCTGAGCCCTGTTTTGCCTGGGCTATTTGTGGGACTCAGACTCTGACCAGGGGGGCGGGATAGTAACCCAGAAGTGCTTCAGGGGCTTAACGCA...
pathogenic
245,475
Considering the variant on chromosome 16, location 3243408, involving gene MEFV, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autoinflammatory_syndrome', 'Familial_Mediterranean_fever', 'Familial_Mediterranean_fever,_autosomal_dominant']
GTCATGTGAACTGTCCTGGGATGTGGATTACTCTTATAGAATAAAACTCGTGGAGGAAAGCCCAGCAAGTTTACCTGCTCTCATCATAGCCATGGAGTATCTGAGTCTAATCTACACTCTAGTAGTGAAGACAGAGGAGTTGGCATAGGAGTTTGGAATTTAATCTTCATTTGATTTTTTTCTTCTTACATCCACTTTTTGGAGACAGGGACTCACTCTGTTGCCCAGGCTGGATTGCCGTAGTGCAGTCTCAGTTCACTGCTGCAGCCTCGATCTCCTGCGCTCAAGCCATCCTCCCACCCCCATCCCTATGGCTAATT...
GTCATGTGAACTGTCCTGGGATGTGGATTACTCTTATAGAATAAAACTCGTGGAGGAAAGCCCAGCAAGTTTACCTGCTCTCATCATAGCCATGGAGTATCTGAGTCTAATCTACACTCTAGTAGTGAAGACAGAGGAGTTGGCATAGGAGTTTGGAATTTAATCTTCATTTGATTTTTTTCTTCTTACATCCACTTTTTGGAGACAGGGACTCACTCTGTTGCCCAGGCTGGATTGCCGTAGTGCAGTCTCAGTTCACTGCTGCAGCCTCGATCTCCTGCGCTCAAGCCATCCTCCCACCCCCATCCCTATGGCTAATT...
pathogenic
245,512
Variant at chromosome 16, position 3244154, gene MEFV: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
TAATCCCTGCACTTTGGGAGGCTGAGGTGGGTGCATCACCTGAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATGATGAAACCTCATGTCTACTAAAAATGCAAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAATCCCAGCTACTTCGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCGGAGGTTGCGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAAGAGCAAAACTTTGTCTCAAAAAAAAAAAAAAAAAAGAATCATAGGCCGGGCACAGTGGCTCATGCCTGTAATCCCAGCACT...
TAATCCCTGCACTTTGGGAGGCTGAGGTGGGTGCATCACCTGAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATGATGAAACCTCATGTCTACTAAAAATGCAAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAATCCCAGCTACTTCGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCGGAGGTTGCGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAAGAGCAAAACTTTGTCTCAAAAAAAAAAAAAAAAAAGAATCATAGGCCGGGCACAGTGGCTCATGCCTGTAATCCCAGCACT...
benign
245,523
Clinical significance of chromosome 16, position 3582617, gene SLX4 (SLX4 structure-specific endonuclease subunit): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Fanconi_anemia']
ATCTCAGCCTCTCAAATTGTTCGCCCCGGGCACCGTAAGCTGGGAGGCCTGGGCCTCTCCGCTGGTTCACGTGCCAGGACATAGTATGTGCGCCAGAAATCACATTTCACCCCCTAAATGCTGCTGAGCCCTAAGATGCAGCTCACAAACCCCTCTTCTGGGAGGCTGTCCCTGACACGGCCCTTCAAGCCACTGGAGCCCGACTCCCCACCAGGCTGGGATAGGCCAGCGTCTGTCTCCTCCACTGGACCGGACGCAATGGTAAAGGCATGTGCTGTCTTGGTGAGTTGTGGGGTGGGGCCTGAATCTGCTTTTGTAGC...
ATCTCAGCCTCTCAAATTGTTCGCCCCGGGCACCGTAAGCTGGGAGGCCTGGGCCTCTCCGCTGGTTCACGTGCCAGGACATAGTATGTGCGCCAGAAATCACATTTCACCCCCTAAATGCTGCTGAGCCCTAAGATGCAGCTCACAAACCCCTCTTCTGGGAGGCTGTCCCTGACACGGCCCTTCAAGCCACTGGAGCCCGACTCCCCACCAGGCTGGGATAGGCCAGCGTCTGTCTCCTCCACTGGACCGGACGCAATGGTAAAGGCATGTGCTGTCTTGGTGAGTTGTGGGGTGGGGCCTGAATCTGCTTTTGTAGC...
pathogenic
245,612
Determine if the mutation at chromosome 16, position 3583488 in gene SLX4 (SLX4 structure-specific endonuclease subunit) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
CAATGACAAGTGTCCGGGTAGCACGGCTGGGTCAGGAGAACTGCATCTGGGCTGTGGCAGTGCAGGGAGCCTCAGGACACCTGGTCTCAGGCTGGCGGTGGCTGGGGTTGGCCTGAGTGCTGAGGAGGACGGGCCCGGGCTGCCGGGGCAGGCTGGACCTGACGTCCATCTCAGGACAGACATGTAGGGCAGCTGTGCCCAGGACTGGTGGGCTCAGAGGGTGGCAAATGTGGCAGAATAGGCCATGCCCTGGCCAGCTGGTGATGGCCCACTGCCCCCTGGGACAGCTGAGGGCCCTCTTGGGTTAAGGGAGACACACT...
CAATGACAAGTGTCCGGGTAGCACGGCTGGGTCAGGAGAACTGCATCTGGGCTGTGGCAGTGCAGGGAGCCTCAGGACACCTGGTCTCAGGCTGGCGGTGGCTGGGGTTGGCCTGAGTGCTGAGGAGGACGGGCCCGGGCTGCCGGGGCAGGCTGGACCTGACGTCCATCTCAGGACAGACATGTAGGGCAGCTGTGCCCAGGACTGGTGGGCTCAGAGGGTGGCAAATGTGGCAGAATAGGCCATGCCCTGGCCAGCTGGTGATGGCCCACTGCCCCCTGGGACAGCTGAGGGCCCTCTTGGGTTAAGGGAGACACACT...
pathogenic
245,625
Does the variant on chromosome 16 at location 3589547 affecting gene SLX4 (SLX4 structure-specific endonuclease subunit) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
GGTTCTTCTGCCTTTTATGACCATGGAGCCCTTTGAGCCCCCGATGAAAGCGGCAGGCTCTGTCTCCTGAGAAAAGCACGATTCTTCCTGTGGCCGCAGCGTCGTCCTGAAGCCCACCTCAGATCTGCTGTGCAGCCTCCTGCAGCTGTTCTCACAGCACTGCCTGGGAACTGGTTAGAAATGCAAATTCTTAGTCACCCTCCCGAAGCAAGGCTCTGGGGCAGGCTGGGCCACGGGCGTGCTATAAGAAGCTCTCCAGGTGTTTCTGAAGCCCCTGAGGGCCGAGGACACTATCAGTGGCCTCATTCATCTGGATTTTG...
GGTTCTTCTGCCTTTTATGACCATGGAGCCCTTTGAGCCCCCGATGAAAGCGGCAGGCTCTGTCTCCTGAGAAAAGCACGATTCTTCCTGTGGCCGCAGCGTCGTCCTGAAGCCCACCTCAGATCTGCTGTGCAGCCTCCTGCAGCTGTTCTCACAGCACTGCCTGGGAACTGGTTAGAAATGCAAATTCTTAGTCACCCTCCCGAAGCAAGGCTCTGGGGCAGGCTGGGCCACGGGCGTGCTATAAGAAGCTCTCCAGGTGTTTCTGAAGCCCCTGAGGGCCGAGGACACTATCAGTGGCCTCATTCATCTGGATTTTG...
pathogenic
245,661
Evaluate if the mutation on chromosome 16 at position 3589741 in SLX4 (SLX4 structure-specific endonuclease subunit) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
TCACCCTCCCGAAGCAAGGCTCTGGGGCAGGCTGGGCCACGGGCGTGCTATAAGAAGCTCTCCAGGTGTTTCTGAAGCCCCTGAGGGCCGAGGACACTATCAGTGGCCTCATTCATCTGGATTTTGGGAGGAAATGGGCCCCCAGGCCGCAGGCAGGTGCTCACTCACAGCCTGGCCTTTCTCCCAGTCATGCTCAGCCCAGCCCGGCCTGTCCTTGCCCTCCCCGGAGGTGCCTGGATGGGAGCAGCAGCACCGAGGGGGCCGACACCTGGGGCTCTGACTCTCCCCGGGGACTGAAATGAGCAGGGAGGTGGCATCCC...
TCACCCTCCCGAAGCAAGGCTCTGGGGCAGGCTGGGCCACGGGCGTGCTATAAGAAGCTCTCCAGGTGTTTCTGAAGCCCCTGAGGGCCGAGGACACTATCAGTGGCCTCATTCATCTGGATTTTGGGAGGAAATGGGCCCCCAGGCCGCAGGCAGGTGCTCACTCACAGCCTGGCCTTTCTCCCAGTCATGCTCAGCCCAGCCCGGCCTGTCCTTGCCCTCCCCGGAGGTGCCTGGATGGGAGCAGCAGCACCGAGGGGGCCGACACCTGGGGCTCTGACTCTCCCCGGGGACTGAAATGAGCAGGGAGGTGGCATCCC...
pathogenic
245,668
Gene SLX4 (SLX4 structure-specific endonuclease subunit) variant at chromosome position 3589994 on chromosome 16: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
CGAGGGGGCCGACACCTGGGGCTCTGACTCTCCCCGGGGACTGAAATGAGCAGGGAGGTGGCATCCCTGCACCTGGGAGGACCAGGAAGAACAGGCCTAACAGCCTCTCACACTTGTCCCACCTGATTCTTTTTTTAATTGAGGTGAAATTCACATAAAAAAATCGTAAAGGGAATAATTCAGTGGCATTAAGTATTCACAATGTTGTACAACCATCACCTCTATCTATTTGCAAAACATTTTCACCACCCCAAAAGGACACCCTGTATCCCATAAGCAGTCACTCCCCATTCCCCCTCCCTCCAACCCAGGCCAACCAC...
CGAGGGGGCCGACACCTGGGGCTCTGACTCTCCCCGGGGACTGAAATGAGCAGGGAGGTGGCATCCCTGCACCTGGGAGGACCAGGAAGAACAGGCCTAACAGCCTCTCACACTTGTCCCACCTGATTCTTTTTTTAATTGAGGTGAAATTCACATAAAAAAATCGTAAAGGGAATAATTCAGTGGCATTAAGTATTCACAATGTTGTACAACCATCACCTCTATCTATTTGCAAAACATTTTCACCACCCCAAAAGGACACCCTGTATCCCATAAGCAGTCACTCCCCATTCCCCCTCCCTCCAACCCAGGCCAACCAC...
pathogenic
245,681
Variant chromosome 16, position 3590052, gene SLX4 (SLX4 structure-specific endonuclease subunit): benign or pathogenic? Disease(s)?
benign
TGGCATCCCTGCACCTGGGAGGACCAGGAAGAACAGGCCTAACAGCCTCTCACACTTGTCCCACCTGATTCTTTTTTTAATTGAGGTGAAATTCACATAAAAAAATCGTAAAGGGAATAATTCAGTGGCATTAAGTATTCACAATGTTGTACAACCATCACCTCTATCTATTTGCAAAACATTTTCACCACCCCAAAAGGACACCCTGTATCCCATAAGCAGTCACTCCCCATTCCCCCTCCCTCCAACCCAGGCCAACCACTAACCTGCATTTTCTCTGGATTTGCCTATTCTAGACATTTCATATCCATGAGTGCAGA...
TGGCATCCCTGCACCTGGGAGGACCAGGAAGAACAGGCCTAACAGCCTCTCACACTTGTCCCACCTGATTCTTTTTTTAATTGAGGTGAAATTCACATAAAAAAATCGTAAAGGGAATAATTCAGTGGCATTAAGTATTCACAATGTTGTACAACCATCACCTCTATCTATTTGCAAAACATTTTCACCACCCCAAAAGGACACCCTGTATCCCATAAGCAGTCACTCCCCATTCCCCCTCCCTCCAACCCAGGCCAACCACTAACCTGCATTTTCTCTGGATTTGCCTATTCTAGACATTTCATATCCATGAGTGCAGA...
benign
245,686
Gene SLX4 (SLX4 structure-specific endonuclease subunit) variant at chromosome position 3590783 on chromosome 16: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
GATGTGGATTTTTAACACATGCCCAGGTGAGCACTGGAGCCAGGCAAGTTTGGGAAACACTGACTTACTGGCTGAGAAGTGTAGCATGAGAACCAGCCCGGCTCTCCTCCACTGTGGAGGGGAGTCTGGAAGGCAGCGGAAGTGTCATGCCTCAGGTCAGCAGGCATTCAGAGGGCAGCCCCTGGGTCTCATGACTGATCTTCCCACCCTCTTAGTGTAAAATAGTAACAAAGACAGTCCCCTTCCCCAGCTCTCCTGGCTACTCACTGGGTGTCTCTAACCCTTCGGGCTTCTGAGCTCCACCAGCGCTTGGCATCTGG...
GATGTGGATTTTTAACACATGCCCAGGTGAGCACTGGAGCCAGGCAAGTTTGGGAAACACTGACTTACTGGCTGAGAAGTGTAGCATGAGAACCAGCCCGGCTCTCCTCCACTGTGGAGGGGAGTCTGGAAGGCAGCGGAAGTGTCATGCCTCAGGTCAGCAGGCATTCAGAGGGCAGCCCCTGGGTCTCATGACTGATCTTCCCACCCTCTTAGTGTAAAATAGTAACAAAGACAGTCCCCTTCCCCAGCTCTCCTGGCTACTCACTGGGTGTCTCTAACCCTTCGGGCTTCTGAGCTCCACCAGCGCTTGGCATCTGG...
benign
245,703
Chromosome 16, position 3590828, gene SLX4 (SLX4 structure-specific endonuclease subunit): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
AAGTTTGGGAAACACTGACTTACTGGCTGAGAAGTGTAGCATGAGAACCAGCCCGGCTCTCCTCCACTGTGGAGGGGAGTCTGGAAGGCAGCGGAAGTGTCATGCCTCAGGTCAGCAGGCATTCAGAGGGCAGCCCCTGGGTCTCATGACTGATCTTCCCACCCTCTTAGTGTAAAATAGTAACAAAGACAGTCCCCTTCCCCAGCTCTCCTGGCTACTCACTGGGTGTCTCTAACCCTTCGGGCTTCTGAGCTCCACCAGCGCTTGGCATCTGGGCCGGAGGAGGGGTCTCTGGAGGCCTCTGCTCTTCCCCGTCCCAA...
AAGTTTGGGAAACACTGACTTACTGGCTGAGAAGTGTAGCATGAGAACCAGCCCGGCTCTCCTCCACTGTGGAGGGGAGTCTGGAAGGCAGCGGAAGTGTCATGCCTCAGGTCAGCAGGCATTCAGAGGGCAGCCCCTGGGTCTCATGACTGATCTTCCCACCCTCTTAGTGTAAAATAGTAACAAAGACAGTCCCCTTCCCCAGCTCTCCTGGCTACTCACTGGGTGTCTCTAACCCTTCGGGCTTCTGAGCTCCACCAGCGCTTGGCATCTGGGCCGGAGGAGGGGTCTCTGGAGGCCTCTGCTCTTCCCCGTCCCAA...
pathogenic
245,707
Is the genetic mutation found on chromosome 16 at position 3600976, within the gene SLX4 (SLX4 structure-specific endonuclease subunit), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
GTTCTGATGACCACAGGCTTGGCCTTTGGGGAGGGAGGGGTTCAAAGACCCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCC...
GTTCTGATGACCACAGGCTTGGCCTTTGGGGAGGGAGGGGTTCAAAGACCCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCC...
pathogenic
245,795
Clinically, how would you classify the variant at chromosome 16, position 3601016, gene SLX4 (SLX4 structure-specific endonuclease subunit): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Fanconi_anemia']
TTCAAAGACCCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCCAGCTCAGCTGCCCATGACCTGTGTGCAAAGCAGGGGGCGG...
TTCAAAGACCCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCCAGCTCAGCTGCCCATGACCTGTGTGCAAAGCAGGGGGCGG...
pathogenic
245,799
Chromosome 16, position 3601025, gene SLX4 (SLX4 structure-specific endonuclease subunit): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Fanconi_anemia']
CCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCCAGCTCAGCTGCCCATGACCTGTGTGCAAAGCAGGGGGCGGGACAAACAG...
CCCATGAGGGCATCCAGCTCCTGTAGTTTTCTACTCTGACAACCTTCTAAACGGATCCACATACATCTAGTTTCAGTACTTGGAGGTATTCTAAAGGCAGACATACTTTATCTGAGCAGGTGCTTTTGGCGTGGTCCTGCCAAGAAAGAAACAATGGCTTAGATGACGTCTATTCTAAGGCCTCAAGGCTTGCACCCCTGCCATGCTAAATACAGATGCGCTCCTCCACCAAGAGAATCCCCTCTGCCCTCTGCCATCTCAGCCCCGAGCCAGCTCAGCTGCCCATGACCTGTGTGCAAAGCAGGGGGCGGGACAAACAG...
pathogenic
245,800
The mutation impacting SLX4 (SLX4 structure-specific endonuclease subunit) on chromosome 16 at position 3602207: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
AGAGCTCAACCTAGATTCCATGCATGTGCGGCTCACAACAGGGTTTGTGTTCCTGTGAGTCTAATGCCACCACTGATCTGACAGGAGGCGGAGCTCAGGCAGTAAAGCTTGCCTGCCCGCTGCTCACCTCCTGCTGTGTGGCCAGGTTCCTAACAGGCCACAGACCGGTACTGGTCCGAGGCTGGGGGGTTGGGGACCCCTGCACTAGAGGGTACCGACTGTGGGATCATGGGATTGGAAACTCAGGAAGGACCTTGAGGAAAACAGTGCGAAGATCATTTCTGCACCCCCCTAAAGGGGCAGGTCCAGAGCCTTCCAGA...
AGAGCTCAACCTAGATTCCATGCATGTGCGGCTCACAACAGGGTTTGTGTTCCTGTGAGTCTAATGCCACCACTGATCTGACAGGAGGCGGAGCTCAGGCAGTAAAGCTTGCCTGCCCGCTGCTCACCTCCTGCTGTGTGGCCAGGTTCCTAACAGGCCACAGACCGGTACTGGTCCGAGGCTGGGGGGTTGGGGACCCCTGCACTAGAGGGTACCGACTGTGGGATCATGGGATTGGAAACTCAGGAAGGACCTTGAGGAAAACAGTGCGAAGATCATTTCTGCACCCCCCTAAAGGGGCAGGTCCAGAGCCTTCCAGA...
pathogenic
245,810
Is the variant located on chromosome 16 at position 3608450, gene SLX4 (SLX4 structure-specific endonuclease subunit), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
CCTTCCCGCCTCCCTTCCTCAGAGTTGTATTAACTTATCTCTGTGTGGAAGACAGAAACACACTCATCATACCATTCCCCGCCATCATCTCCTCTTGAGGATCCTTTGGGACATTTTCTTCCCGCGCAGCCTCGAGGGAGCACTCTTCTGAAGCGTGTCTCAAACGCTCGGGGTCTGCTCTCTTGAACTGCTGCATTCGCTGTAGGACCAATTGTGCTGTGCGGGGTTTGGAGGGACTTGGCACTGCTGTTGTCAAACAGGAAGGAGGAGGCTGGGAGTCGCTGTTGGGCACATTCTCTGGCAAGGAGGAAAATATTCAC...
CCTTCCCGCCTCCCTTCCTCAGAGTTGTATTAACTTATCTCTGTGTGGAAGACAGAAACACACTCATCATACCATTCCCCGCCATCATCTCCTCTTGAGGATCCTTTGGGACATTTTCTTCCCGCGCAGCCTCGAGGGAGCACTCTTCTGAAGCGTGTCTCAAACGCTCGGGGTCTGCTCTCTTGAACTGCTGCATTCGCTGTAGGACCAATTGTGCTGTGCGGGGTTTGGAGGGACTTGGCACTGCTGTTGTCAAACAGGAAGGAGGAGGCTGGGAGTCGCTGTTGGGCACATTCTCTGGCAAGGAGGAAAATATTCAC...
pathogenic
245,825
Regarding the variant found on chromosome 16 at position 3608539 in gene SLX4 (SLX4 structure-specific endonuclease subunit): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Fanconi_anemia', 'Fanconi_anemia_complementation_group_P']
TCCTCTTGAGGATCCTTTGGGACATTTTCTTCCCGCGCAGCCTCGAGGGAGCACTCTTCTGAAGCGTGTCTCAAACGCTCGGGGTCTGCTCTCTTGAACTGCTGCATTCGCTGTAGGACCAATTGTGCTGTGCGGGGTTTGGAGGGACTTGGCACTGCTGTTGTCAAACAGGAAGGAGGAGGCTGGGAGTCGCTGTTGGGCACATTCTCTGGCAAGGAGGAAAATATTCACAACCATCTGTTGTAGCTGGAGAAATAAAAGACTTTTCTACCAGATACAGGTTAGACGCAAGTTTCAAGAGTCCTTTATCAACTAGTTTA...
TCCTCTTGAGGATCCTTTGGGACATTTTCTTCCCGCGCAGCCTCGAGGGAGCACTCTTCTGAAGCGTGTCTCAAACGCTCGGGGTCTGCTCTCTTGAACTGCTGCATTCGCTGTAGGACCAATTGTGCTGTGCGGGGTTTGGAGGGACTTGGCACTGCTGTTGTCAAACAGGAAGGAGGAGGCTGGGAGTCGCTGTTGGGCACATTCTCTGGCAAGGAGGAAAATATTCACAACCATCTGTTGTAGCTGGAGAAATAAAAGACTTTTCTACCAGATACAGGTTAGACGCAAGTTTCAAGAGTCCTTTATCAACTAGTTTA...
pathogenic
245,827
A genetic variant on chromosome 16, position 3658281, affects the gene DNASE1. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
CCCAACAGAGCAGGGAAGTAGTTTGTCCTATTAGTTTGTCCTATGGCAAGAACCTGAGGCTTCAGAGCAGGGTCCAGGGTGGAGTGAAAACACCCCAAGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCC...
CCCAACAGAGCAGGGAAGTAGTTTGTCCTATTAGTTTGTCCTATGGCAAGAACCTGAGGCTTCAGAGCAGGGTCCAGGGTGGAGTGAAAACACCCCAAGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCCTGGGTCCCGGACCAATGGGTTGAGCAGGTGCCTGGCTCCCCCGCCCTCCTGTCGCC...
benign
245,849
Evaluate if the mutation on chromosome 16 at position 3728417 in CREBBP (CREB binding protein) is benign or pathogenic. Disease name(s) if pathogenic?
benign
GACAATCACCTGTGAGCCTCGAATGTGTGGGGCCAACGCTGAGCCGCCCACCTCAGTCGCCCACCTCAGTCTCCGGGAAGAAAAGCCTCCGGGCGGCCGCTAAGCCTGGGCCACAGTTCCCAGCCACCACCCACGCCGCCACAACCACAACCGCAGCCCCAGCCTCTCCGCTATGAGCGAACAACCAGAACCATGTCTTACAAAGAACAGACTCAAAAAATATATATAAATAAATAAAAACCTTAAACATTCTTACAGGGATCTTAAAGAACAGAATACATGTTAAAAACCTCAGTAATTTATATCAATTTTAAGCGGTA...
GACAATCACCTGTGAGCCTCGAATGTGTGGGGCCAACGCTGAGCCGCCCACCTCAGTCGCCCACCTCAGTCTCCGGGAAGAAAAGCCTCCGGGCGGCCGCTAAGCCTGGGCCACAGTTCCCAGCCACCACCCACGCCGCCACAACCACAACCGCAGCCCCAGCCTCTCCGCTATGAGCGAACAACCAGAACCATGTCTTACAAAGAACAGACTCAAAAAATATATATAAATAAATAAAAACCTTAAACATTCTTACAGGGATCTTAAAGAACAGAATACATGTTAAAAACCTCAGTAATTTATATCAATTTTAAGCGGTA...
benign
245,900
Mutation found at chromosome 16 position 3728423, gene CREBBP (CREB binding protein): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
CACCTGTGAGCCTCGAATGTGTGGGGCCAACGCTGAGCCGCCCACCTCAGTCGCCCACCTCAGTCTCCGGGAAGAAAAGCCTCCGGGCGGCCGCTAAGCCTGGGCCACAGTTCCCAGCCACCACCCACGCCGCCACAACCACAACCGCAGCCCCAGCCTCTCCGCTATGAGCGAACAACCAGAACCATGTCTTACAAAGAACAGACTCAAAAAATATATATAAATAAATAAAAACCTTAAACATTCTTACAGGGATCTTAAAGAACAGAATACATGTTAAAAACCTCAGTAATTTATATCAATTTTAAGCGGTACTTTAT...
CACCTGTGAGCCTCGAATGTGTGGGGCCAACGCTGAGCCGCCCACCTCAGTCGCCCACCTCAGTCTCCGGGAAGAAAAGCCTCCGGGCGGCCGCTAAGCCTGGGCCACAGTTCCCAGCCACCACCCACGCCGCCACAACCACAACCGCAGCCCCAGCCTCTCCGCTATGAGCGAACAACCAGAACCATGTCTTACAAAGAACAGACTCAAAAAATATATATAAATAAATAAAAACCTTAAACATTCTTACAGGGATCTTAAAGAACAGAATACATGTTAAAAACCTCAGTAATTTATATCAATTTTAAGCGGTACTTTAT...
benign
245,903
Gene CREBBP (CREB binding protein) variant at chromosome 16, position 3729209—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['CREBBP-related_disorder', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
TGCACGCCGGAGTCAATTCCTATCATCCAGGGTAATACTGGGAGACGCCCACAGAGTTCACTATAGAAAAAAATCTTCCCGAAACATCACAAAGTTATCGGGATACATTATAAGCTTGCATTATTTCAGGAATCAGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAA...
TGCACGCCGGAGTCAATTCCTATCATCCAGGGTAATACTGGGAGACGCCCACAGAGTTCACTATAGAAAAAAATCTTCCCGAAACATCACAAAGTTATCGGGATACATTATAAGCTTGCATTATTTCAGGAATCAGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAA...
pathogenic
245,941
Clinically, how would you classify the variant at chromosome 16, position 3729209, gene CREBBP (CREB binding protein): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Rubinstein-Taybi_syndrome', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
TGCACGCCGGAGTCAATTCCTATCATCCAGGGTAATACTGGGAGACGCCCACAGAGTTCACTATAGAAAAAAATCTTCCCGAAACATCACAAAGTTATCGGGATACATTATAAGCTTGCATTATTTCAGGAATCAGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAA...
TGCACGCCGGAGTCAATTCCTATCATCCAGGGTAATACTGGGAGACGCCCACAGAGTTCACTATAGAAAAAAATCTTCCCGAAACATCACAAAGTTATCGGGATACATTATAAGCTTGCATTATTTCAGGAATCAGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAA...
pathogenic
245,942
Chromosome 16, position 3729343, gene CREBBP (CREB binding protein): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Rubinstein-Taybi_syndrome', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
AGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTC...
AGTTCTGAATATTATTTTTCTTCTTACTTTTAAACATAAATGTTTAAAGTCTTGAAAATACAAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTC...
pathogenic
245,948
Chromosome 16, position 3729404, gene CREBBP (CREB binding protein): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Rubinstein-Taybi_syndrome', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
AAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTCGGAAGTCGCAGTTCCATCTAGGAATAAAAAGAACCTAGATGCCTGGATTTTCAGTACAAAA...
AAATAAAAAATATGAATATAATGAACTTGTTTTTCCCGTTAAAAAAAGGCATGAGTCACCAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTCGGAAGTCGCAGTTCCATCTAGGAATAAAAAGAACCTAGATGCCTGGATTTTCAGTACAAAA...
pathogenic
245,951
For chromosome 16, position 3729463, gene CREBBP (CREB binding protein): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic
CAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTCGGAAGTCGCAGTTCCATCTAGGAATAAAAAGAACCTAGATGCCTGGATTTTCAGTACAAAAGGTCCAAGAACATGAAAGGGAAAAGGTGATGCTCTCACAATGCTACAAGCCCTCCACAA...
CAGCAATGACGACAAAAAGAATCCAAACAAAACCCCCCTCCCCCCAAACAAAAACAAAACGGAAAAAAAAGAACCCCCCCCACCCCCCCGCCAAAAAAAAACCAAAGAGAGAGACCAGATATTTAAATCAACTGGTTTTTAACAAAAAAATATATTCTTTGTATTGTTTCTTTAAACATCAATCCACCCTTCCATGGCTCGGAAGTCGCAGTTCCATCTAGGAATAAAAAGAACCTAGATGCCTGGATTTTCAGTACAAAAGGTCCAAGAACATGAAAGGGAAAAGGTGATGCTCTCACAATGCTACAAGCCCTCCACAA...
pathogenic
245,958
Mutation found at chromosome 16 position 3731322, gene CREBBP (CREB binding protein): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['CREBBP-related_disorder', 'Rubinstein-Taybi_syndrome', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
CCACGCTGGGGAAGCCAGCTGGTGACATGCTCACGGGTGAGGGTTGGGGCTGGGCAGGGGGCTGCGGCGTCTGGGGTGTGCTGGGCTGCTGTGTGGGGGTCCCGGGCGGTGCTGAGGTAGGAGAAGGCAGACTCTGCTGAGGCACGTTGCGGGTGTTCATGGTGGCCATCCGCCGGCGCATGAGCTGGGCCTGCTGCAGGCGGTGCTGGATCTGCTGCTGGCGGAGCTTGTGTTTGATGTTGAGGCAGAAGGGCACGGGGCATTTGTTTTCTTGGCAGTGCTTGGCGTGGTAGCAGCAGAGGGCGATGAGCTGCTTGCAC...
CCACGCTGGGGAAGCCAGCTGGTGACATGCTCACGGGTGAGGGTTGGGGCTGGGCAGGGGGCTGCGGCGTCTGGGGTGTGCTGGGCTGCTGTGTGGGGGTCCCGGGCGGTGCTGAGGTAGGAGAAGGCAGACTCTGCTGAGGCACGTTGCGGGTGTTCATGGTGGCCATCCGCCGGCGCATGAGCTGGGCCTGCTGCAGGCGGTGCTGGATCTGCTGCTGGCGGAGCTTGTGTTTGATGTTGAGGCAGAAGGGCACGGGGCATTTGTTTTCTTGGCAGTGCTTGGCGTGGTAGCAGCAGAGGGCGATGAGCTGCTTGCAC...
pathogenic
245,984
Variant at chromosome 16, position 3731464, gene CREBBP (CREB binding protein): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Inborn_genetic_diseases', 'Menke-Hennekam_syndrome_1', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
CACGTTGCGGGTGTTCATGGTGGCCATCCGCCGGCGCATGAGCTGGGCCTGCTGCAGGCGGTGCTGGATCTGCTGCTGGCGGAGCTTGTGTTTGATGTTGAGGCAGAAGGGCACGGGGCATTTGTTTTCTTGGCAGTGCTTGGCGTGGTAGCAGCAGAGGGCGATGAGCTGCTTGCACACCGGGCAGCCCCCGTTGGTCTTGCGTTTGCAGCCCTTGGTGTGCTGCACCACCCGCTTCATCTTCTGGCAGGATGGCAGCGAGCAGTTGGCGTTGCGGCACTGGCACGCGTGCACCAGCGACTGGATGCAGCGCTGGATGC...
CACGTTGCGGGTGTTCATGGTGGCCATCCGCCGGCGCATGAGCTGGGCCTGCTGCAGGCGGTGCTGGATCTGCTGCTGGCGGAGCTTGTGTTTGATGTTGAGGCAGAAGGGCACGGGGCATTTGTTTTCTTGGCAGTGCTTGGCGTGGTAGCAGCAGAGGGCGATGAGCTGCTTGCACACCGGGCAGCCCCCGTTGGTCTTGCGTTTGCAGCCCTTGGTGTGCTGCACCACCCGCTTCATCTTCTGGCAGGATGGCAGCGAGCAGTTGGCGTTGCGGCACTGGCACGCGTGCACCAGCGACTGGATGCAGCGCTGGATGC...
pathogenic
245,989
Evaluate the clinical significance of the mutation at chromosome 16, position 3736109 in gene CREBBP (CREB binding protein): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
CTGGAGCTTTCCCTGGGCACATTTGTCTCCGTGTTTGCGACATTCCTCACGAAGCTGGGACTGCACACAGGGAGCTGGTTCCGTTTCTCGCCCCACCTGACACTATCGCGAGCCTTTCCCCATTTCCCAGAATTGACAGCATGATGCAGAGCAGAGCTAATAGCAAAGCAGTGCTCCACCCCACGCACCAGCCCTCACTAAGGCTGACCCCCAGAGCGAGCTCCTGGGGTGTTGCTGACGAAGGCATGTCCCTGCCCATTGTTGTCCATGAACCAAACACACAAGGGACAGCAGGTCTACATGCCGACACCTCAGCATCC...
CTGGAGCTTTCCCTGGGCACATTTGTCTCCGTGTTTGCGACATTCCTCACGAAGCTGGGACTGCACACAGGGAGCTGGTTCCGTTTCTCGCCCCACCTGACACTATCGCGAGCCTTTCCCCATTTCCCAGAATTGACAGCATGATGCAGAGCAGAGCTAATAGCAAAGCAGTGCTCCACCCCACGCACCAGCCCTCACTAAGGCTGACCCCCAGAGCGAGCTCCTGGGGTGTTGCTGACGAAGGCATGTCCCTGCCCATTGTTGTCCATGAACCAAACACACAAGGGACAGCAGGTCTACATGCCGACACCTCAGCATCC...
pathogenic
245,997
The genetic variant at chromosome 16, position 3757362, affecting gene CREBBP (CREB binding protein): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
GGACCCAGGAACAGGCCCCACAACACTTTAGAGACAGTGGTAAACAATCTACCTTCCTTCTAGACCAAAACTGTGTTGGGCAACGTAGCAGGGGTGGCATTTTTCTGGGTGTAGTTAATATTAACCTTTCTCTGAAGATATCATTAACTTTATTTTGCTTGGCACAAATGGTTTTTAAAGTGCATTCCTATTCATTATTTCATCATTGAGGACCTGACAAAATGAGGCTGCGAGGGAAGACGCTATTGTCTGTATCACAGACAAGGCTAAGCTTAATACATTAATACATCATGGGGTCTGCTGAAGGTCATGGGGCTAAA...
GGACCCAGGAACAGGCCCCACAACACTTTAGAGACAGTGGTAAACAATCTACCTTCCTTCTAGACCAAAACTGTGTTGGGCAACGTAGCAGGGGTGGCATTTTTCTGGGTGTAGTTAATATTAACCTTTCTCTGAAGATATCATTAACTTTATTTTGCTTGGCACAAATGGTTTTTAAAGTGCATTCCTATTCATTATTTCATCATTGAGGACCTGACAAAATGAGGCTGCGAGGGAAGACGCTATTGTCTGTATCACAGACAAGGCTAAGCTTAATACATTAATACATCATGGGGTCTGCTGAAGGTCATGGGGCTAAA...
pathogenic
246,044
Considering the variant on chromosome 16, location 3758051, involving gene CREBBP (CREB binding protein), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
benign
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
benign
246,049
Evaluate if the mutation on chromosome 16 at position 3758051 in CREBBP (CREB binding protein) is benign or pathogenic. Disease name(s) if pathogenic?
benign
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
benign
246,050
Is the genetic variant on chromosome 16, position 3758051, gene CREBBP (CREB binding protein), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
TATTACTTATCTTGAATATGGATTTTTAAAAAAAACATAGAAGAATTAAAACACATAACCATAAAACTCCAAAATTTTCAGGCCTGTGAACAAATAACAAAAAGCCTTCTGTCTTCTTTGAAGTATAGGACATAATTACTCTGACCAAATGAGAGTAAAATAATAAAAAACGCCAAACCCCACTGTTGACGCTTATTATTTGAACCTAAAGACAAAGAACAGGCACAAACCTCTATCTTGGCCACAGAGAATCCAGCTGCTGGCTCATAAAATAGAGGCAACGTCACAGTTTGAGCAAGATTCCTGACCTGTGCCTCCAC...
benign
246,051
Is the genetic variant on chromosome 16, position 3758852, gene CREBBP (CREB binding protein), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
GAAAAAGGCATGTCAACCTTTATCAGAGTTACTCTCAACTTCAGACGCTTGCTTCTAGGGCTGCGTTTTAGAACGGGCAGGGCTGAAGAAATAACGTACCTAATCCAAGTAGTACGGCAAGACTTGGCTCTGAGGTTACAGTTTTTACACTGTAAAAGTACGCTTTATAACTAACTAAGAGGCCATGGGCCTAAGTGACTAACAAGACACTGAAACCGAGCCACTTTTTCTCTTTTTTTTTCTTTTCAAATAGAGATGGGGGTTTCTCTATGTCGCCAAGGCTGATAACATAACTCCTGGGCTCAAGTGATTCTCCCACC...
GAAAAAGGCATGTCAACCTTTATCAGAGTTACTCTCAACTTCAGACGCTTGCTTCTAGGGCTGCGTTTTAGAACGGGCAGGGCTGAAGAAATAACGTACCTAATCCAAGTAGTACGGCAAGACTTGGCTCTGAGGTTACAGTTTTTACACTGTAAAAGTACGCTTTATAACTAACTAAGAGGCCATGGGCCTAAGTGACTAACAAGACACTGAAACCGAGCCACTTTTTCTCTTTTTTTTTCTTTTCAAATAGAGATGGGGGTTTCTCTATGTCGCCAAGGCTGATAACATAACTCCTGGGCTCAAGTGATTCTCCCACC...
pathogenic
246,054
Is the genetic variant on chromosome 16, position 3767867, gene CREBBP (CREB binding protein), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Rubinstein-Taybi_syndrome', 'Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations']
TTTTTAATAGAGATTAGGTTTCGCCATGTTGCCTAGGCTGCTCTCGAACTCCTGAGCTCCAGGCTAGAGTGCAGTGGTGCAATCATAGACCCTGAATTCCTGGGCTCAAGCAATCCTTCCCCCTCAGCCTCCCAAAATGCTGAGATTACGGGTGTGAGCCACCATGCACGCCCTGCTTTTCTAAGTTGGTAAGACTTGTTTGAAGAGACTGATGGTGGTATTAACAAATGTTGATTTTTTTTTGACACTGTATAGTGAAATATGTCAACATATGGAAAATCTGCAGAACTTAAGTGTCAATTGAAAAAAAAATCATGCAA...
TTTTTAATAGAGATTAGGTTTCGCCATGTTGCCTAGGCTGCTCTCGAACTCCTGAGCTCCAGGCTAGAGTGCAGTGGTGCAATCATAGACCCTGAATTCCTGGGCTCAAGCAATCCTTCCCCCTCAGCCTCCCAAAATGCTGAGATTACGGGTGTGAGCCACCATGCACGCCCTGCTTTTCTAAGTTGGTAAGACTTGTTTGAAGAGACTGATGGTGGTATTAACAAATGTTGATTTTTTTTTGACACTGTATAGTGAAATATGTCAACATATGGAAAATCTGCAGAACTTAAGTGTCAATTGAAAAAAAAATCATGCAA...
pathogenic
246,063
Clinical classification of chromosome 16, position 5072071, gene ALG1: benign or pathogenic? Disease(s) if pathogenic?
benign
GATGGCTCCGTCCCCTCTCTCCAGGAGACACCACGGCAACTCCCTCCCCGACGGAGGTTCACCTACCAGAGGGAGGCATCTACTTTTGGTTTGTCATCACCATAGTCTTTATCCTCTTAGCTCATCAGAGCAGGACAGGCTCTCAAAGACTTGAAGTTCCCCTCCCTTAATTCACAGACGAAGAAAGCAAATTGATGGGGAGTGACTCGCCCGAGGTGGAGCAGGAAAGCCAGGAGTCCTGAGGCTGAGGTCCCAGATCCCTACCTGTCCCATTACAGAGCGTCGACAGAGTTGGGCAGGCGATGTGTCACAGGCCTCCA...
GATGGCTCCGTCCCCTCTCTCCAGGAGACACCACGGCAACTCCCTCCCCGACGGAGGTTCACCTACCAGAGGGAGGCATCTACTTTTGGTTTGTCATCACCATAGTCTTTATCCTCTTAGCTCATCAGAGCAGGACAGGCTCTCAAAGACTTGAAGTTCCCCTCCCTTAATTCACAGACGAAGAAAGCAAATTGATGGGGAGTGACTCGCCCGAGGTGGAGCAGGAAAGCCAGGAGTCCTGAGGCTGAGGTCCCAGATCCCTACCTGTCCCATTACAGAGCGTCGACAGAGTTGGGCAGGCGATGTGTCACAGGCCTCCA...
benign
246,346
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 16, position 5075536, gene ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). What disease(s) is it linked to if pathogenic?
pathogenic; ['ALG1-congenital_disorder_of_glycosylation']
TTAACTCATTTAGTCCTCACAGTTACCCTAAGAAATATTGCATGTAGGTAATACAAGAACCTGTTTCTTAAGGTTGTTCTCATTTAGATGAGAAAACCTAGACTGAGAAAGGCTCTGTAAGTAGCCCATCGCCATACAGCTAGGAAGTGGTGGAATCAGGATTTGAACGTAGGTCGTCAGTGTGGTTCTATAGTATACACACGCACGCATACGCGCGCACACACAAACACACATATATTTTTTTGAGACAGAGTTTCGCTCTTGCCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCTGCCTGCC...
TTAACTCATTTAGTCCTCACAGTTACCCTAAGAAATATTGCATGTAGGTAATACAAGAACCTGTTTCTTAAGGTTGTTCTCATTTAGATGAGAAAACCTAGACTGAGAAAGGCTCTGTAAGTAGCCCATCGCCATACAGCTAGGAAGTGGTGGAATCAGGATTTGAACGTAGGTCGTCAGTGTGGTTCTATAGTATACACACGCACGCATACGCGCGCACACACAAACACACATATATTTTTTTGAGACAGAGTTTCGCTCTTGCCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCTGCCTGCC...
pathogenic
246,370
Variant in gene ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase), located at chromosome 16 position 5078737: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
AATCCCTTTGCCCCACGTTGAGAGCAAGCCGTGACCTTACAGCCTTTGCAGTGGTAGCACAGGGTGGCTGAGATCGCTAGTGAGGCCTTCATTGTATTTCTTCCTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTATGTCCCAGACTGGAGTGCAATGGCGCCATCTCGGCTCACTGCAGCCTCCGCCTTCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCCACCACCACGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGGCT...
AATCCCTTTGCCCCACGTTGAGAGCAAGCCGTGACCTTACAGCCTTTGCAGTGGTAGCACAGGGTGGCTGAGATCGCTAGTGAGGCCTTCATTGTATTTCTTCCTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTATGTCCCAGACTGGAGTGCAATGGCGCCATCTCGGCTCACTGCAGCCTCCGCCTTCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCCACCACCACGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGGCT...
benign
246,391
Considering the variant on chromosome 16, location 5080972, involving gene ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['ALG1-congenital_disorder_of_glycosylation']
TGGCCAACCTGTGTTCTCCTCACCCCTGCCAGTCCTGCATGCTCCCACCCTGCCACGGTCTCAATGAGAACGGGAGGGCCTGTGAGCTGGAAGAGGGGTGTCTAGAAACAGGCCCCTGACATTCAATTCTCTTCTCATAGAGGACGAAGACTTCTCCATCCTGCTGGCAGCTTTAGAAAGTAGGTGTGTGGCTGCGGTGAGGAGCTCTGGGCTTGTCGGGGGCCACTGAGCTGTAAGCTGCTTGCCTGGCCTGCAGCATGTTCCTGTCCCAGGCCACTGGGTGGGGCAGCCTGGGGACAGCGGGGGTGGTGGAAGTGGGC...
TGGCCAACCTGTGTTCTCCTCACCCCTGCCAGTCCTGCATGCTCCCACCCTGCCACGGTCTCAATGAGAACGGGAGGGCCTGTGAGCTGGAAGAGGGGTGTCTAGAAACAGGCCCCTGACATTCAATTCTCTTCTCATAGAGGACGAAGACTTCTCCATCCTGCTGGCAGCTTTAGAAAGTAGGTGTGTGGCTGCGGTGAGGAGCTCTGGGCTTGTCGGGGGCCACTGAGCTGTAAGCTGCTTGCCTGGCCTGCAGCATGTTCCTGTCCCAGGCCACTGGGTGGGGCAGCCTGGGGACAGCGGGGGTGGTGGAAGTGGGC...
pathogenic
246,418
Regarding the variant found on chromosome 16 at position 5082574 in gene ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['ALG1-congenital_disorder_of_glycosylation']
CTCCTCCCTCCTCTGGCCTCTAGGCTCCCAGGAGTGGTTTGGAACCCGCGCCATATGCTCTGGGGGCTGTGCCAGGGCAGGAGGAGTCCTCGTGTCCCCTGTGCACAACACAGACAAAAGGCTGGGTCCACCCAGTGGGCGGTCGGGTGCCAGGCCAGTGCTTACCCCGCCATGTTTGCAGCCCGAGGCCAGCTGGCTGCAGGTGAAAGGCTATGCGTCAGGGGTCAGGGTGCACACACCCCTGCAGGTCTCAGGGCTCCTGGGTTGCTTCTGGAAGGGCCCGGATGGGGCCTGACTGGAGCTGCTGAGGGGTGGAGCTT...
CTCCTCCCTCCTCTGGCCTCTAGGCTCCCAGGAGTGGTTTGGAACCCGCGCCATATGCTCTGGGGGCTGTGCCAGGGCAGGAGGAGTCCTCGTGTCCCCTGTGCACAACACAGACAAAAGGCTGGGTCCACCCAGTGGGCGGTCGGGTGCCAGGCCAGTGCTTACCCCGCCATGTTTGCAGCCCGAGGCCAGCTGGCTGCAGGTGAAAGGCTATGCGTCAGGGGTCAGGGTGCACACACCCCTGCAGGTCTCAGGGCTCCTGGGTTGCTTCTGGAAGGGCCCGGATGGGGCCTGACTGGAGCTGCTGAGGGGTGGAGCTT...
pathogenic
246,428
Regarding the variant found on chromosome 16 at position 5083744 in gene ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['ALG1-congenital_disorder_of_glycosylation', 'Congenital_disorder_of_glycosylation']
GGATTACAGGAGCCCACCACAACACCTGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCTCCTGCCTTGGCCTTCCTAAGTGCTTGGATTCCAGGTGTGACCCATCACGCCTGGCCCCAGCTAGTCTTTAGAAATGTTAAGCTATTTGGCTTTATTTTCACAGTGACAGCTGGTTTGTGGTGGGTGTGCTGTGGTTTATTATTATTATCATTTTGAGATGGAGTTTCGCTCTTGTAGACCAGGCTGGAGTGCAATGGTGTGATCTTGGCT...
GGATTACAGGAGCCCACCACAACACCTGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCTCCTGCCTTGGCCTTCCTAAGTGCTTGGATTCCAGGTGTGACCCATCACGCCTGGCCCCAGCTAGTCTTTAGAAATGTTAAGCTATTTGGCTTTATTTTCACAGTGACAGCTGGTTTGTGGTGGGTGTGCTGTGGTTTATTATTATTATCATTTTGAGATGGAGTTTCGCTCTTGTAGACCAGGCTGGAGTGCAATGGTGTGATCTTGGCT...
pathogenic
246,443
Variant at chromosome position 5084897, chromosome 16, gene ALG1: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
GTAGTTGCTTCCATTTAGAGCTCATGTTATATTTAGGTTGGTACAAAAGTAATCATGGTTTTTGCCATTAAAAATGGCAACTACTTTTGCACCAACCCAATATGAAAACAAAAAGCACCTTAAATACCAGAACTCCACTCGGGGCTTTTGCTCCTAGGGTAGAATTGGTGGGAATTGCCTGCAGGCTTACATGGTTTTCTTTGTTTTTCTCTCCCACCATGTCCCTTTTGGCCAAGCTCACATGGTCGGTTTGAATCAGTTAAATGAGTGTCATGCTGTGGCCTCACTGCACCCAGCGTAGACGGGTGTTTGGAAGGGCA...
GTAGTTGCTTCCATTTAGAGCTCATGTTATATTTAGGTTGGTACAAAAGTAATCATGGTTTTTGCCATTAAAAATGGCAACTACTTTTGCACCAACCCAATATGAAAACAAAAAGCACCTTAAATACCAGAACTCCACTCGGGGCTTTTGCTCCTAGGGTAGAATTGGTGGGAATTGCCTGCAGGCTTACATGGTTTTCTTTGTTTTTCTCTCCCACCATGTCCCTTTTGGCCAAGCTCACATGGTCGGTTTGAATCAGTTAAATGAGTGTCATGCTGTGGCCTCACTGCACCCAGCGTAGACGGGTGTTTGGAAGGGCA...
benign
246,456
Clinical impact (benign or pathogenic) of the variant at chromosome 16, location 8764843, gene ABAT (4-aminobutyrate aminotransferase): what disease(s) if pathogenic?
benign
GAAGGAAATGTTCCTTAAAGTCCCCTCCAAGGTTGGGCACAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGTCCAAGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTATAAAAAAATACAAAAAATTAGCTGGGTGCGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGTGGGAGGATCACTTGAGTCTCGGAGGTTGAGGCTGCAGTAAGCTGATATCACGCTACTGCACTCCAACCTGAGAGAGCAAGACCCTGTAACAAAAAAAAAA...
GAAGGAAATGTTCCTTAAAGTCCCCTCCAAGGTTGGGCACAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGTCCAAGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTATAAAAAAATACAAAAAATTAGCTGGGTGCGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGTGGGAGGATCACTTGAGTCTCGGAGGTTGAGGCTGCAGTAAGCTGATATCACGCTACTGCACTCCAACCTGAGAGAGCAAGACCCTGTAACAAAAAAAAAA...
benign
246,496
Clinical significance of chromosome 16, position 8764843, gene ABAT (4-aminobutyrate aminotransferase): benign or pathogenic? Name the disease(s) if pathogenic.
benign
GAAGGAAATGTTCCTTAAAGTCCCCTCCAAGGTTGGGCACAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGTCCAAGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTATAAAAAAATACAAAAAATTAGCTGGGTGCGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGTGGGAGGATCACTTGAGTCTCGGAGGTTGAGGCTGCAGTAAGCTGATATCACGCTACTGCACTCCAACCTGAGAGAGCAAGACCCTGTAACAAAAAAAAAA...
GAAGGAAATGTTCCTTAAAGTCCCCTCCAAGGTTGGGCACAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGTCCAAGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTATAAAAAAATACAAAAAATTAGCTGGGTGCGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGTGGGAGGATCACTTGAGTCTCGGAGGTTGAGGCTGCAGTAAGCTGATATCACGCTACTGCACTCCAACCTGAGAGAGCAAGACCCTGTAACAAAAAAAAAA...
benign
246,497
Evaluate the clinical significance of the mutation at chromosome 16, position 8797895 in gene PMM2 (phosphomannomutase 2): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
AAGTCTCCAAGTACCCAGTCCCCTTTCTTCAGCCTTGCCCACACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGG...
AAGTCTCCAAGTACCCAGTCCCCTTTCTTCAGCCTTGCCCACACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGG...
pathogenic
246,549
The genetic variant at chromosome 16, position 8797905, affecting gene PMM2 (phosphomannomutase 2): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation', 'PMM2-related_disorder']
GTACCCAGTCCCCTTTCTTCAGCCTTGCCCACACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAG...
GTACCCAGTCCCCTTTCTTCAGCCTTGCCCACACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAG...
pathogenic
246,550
Does the chromosome 16 mutation at position 8797936 within gene PMM2 (phosphomannomutase 2) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
CACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAGCATGGTGCCAGACTCATTCAGATACAGGATA...
CACCCTCAGCCTTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAGCATGGTGCCAGACTCATTCAGATACAGGATA...
pathogenic
246,557
Is the genetic mutation found on chromosome 16 at position 8797947, within the gene PMM2 (phosphomannomutase 2), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
TTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAGCATGGTGCCAGACTCATTCAGATACAGGATACCAACCAGTCT...
TTCCTGTTAATCCAGGCGACCCAGGGTTACCCAGAGGTCCAGGTCCCAGTTGTTCACTTGAGCATCTGATGTACCCCAAACACCTGTGTGAAACGCTCTCTGTCCAGGATGCGTCCATAGCGCAGGGTGACGTAGAAGGTCTGTTTCCCACTGTACCGCTGGATACGCACAAACATCTCCTGAGGCCGGTCCTTGGTTTCTGTCAGGGGAATCACATCTGCCATGGGACAGTATGTGTCCTGCCGCCAGCCCCAGAAGTTCAGATGGGCCACCCGCAGCATGGTGCCAGACTCATTCAGATACAGGATACCAACCAGTCT...
pathogenic
246,559
The mutation in gene PMM2 (phosphomannomutase 2) at chromosome 16, position 8801802—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GCCAGGATGGTCTCTATCTCTGGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGTTCTGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATA...
GCCAGGATGGTCTCTATCTCTGGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGTTCTGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATA...
pathogenic
246,564
Variant chromosome 16, position 8801827, gene PMM2 (phosphomannomutase 2): benign or pathogenic? Disease(s)?
pathogenic; ['Inborn_genetic_diseases', 'PMM2-congenital_disorder_of_glycosylation', 'PMM2-related_disorder']
CTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGTTCTGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATATTCAGCCGGGCACGGTAGTTCATGC...
CTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGTTCTGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATATTCAGCCGGGCACGGTAGTTCATGC...
pathogenic
246,566
Determine whether the variant at chromosome 16, position 8801890, in gene PMM2 (phosphomannomutase 2) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
TGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATATTCAGCCGGGCACGGTAGTTCATGCCTATAATCCCAGCACTTGGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTCGAGAC...
TGACTTTTAAAGGCCACTCCTCCAATTCTAGATTCTGTCTAATAGGTCCAGATTCCACTGTGAGAGTAGAAAAGATTGCACTCTATTACAAACCCTTCTGTACAATTTTAATCACATTCATGTATTACTCTAAAAAAGTTTTTTAAAGAAAAATCATTGAACTCCAAGTGTTTATATACTGAGGTTGAATTAAATGGTTTTTTGTATTTTCTAAATTTCTAGTAAAAAGATATTCAGCCGGGCACGGTAGTTCATGCCTATAATCCCAGCACTTGGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTCGAGAC...
pathogenic
246,574
Chromosome 16, position 8804745, gene PMM2 (phosphomannomutase 2): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
ACGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCT...
ACGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCT...
benign
246,582
Regarding the variant at chromosome 16 and position 8804777, affecting gene PMM2 (phosphomannomutase 2): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation', 'PMM2-related_disorder']
CCGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGAT...
CCGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGAT...
pathogenic
246,585
Variant chromosome 16, position 8804782, gene PMM2 (phosphomannomutase 2): benign or pathogenic? Disease(s)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCA...
GCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCA...
pathogenic
246,587
Variant in gene PMM2 (phosphomannomutase 2), located at chromosome 16 position 8804785: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCACAG...
GGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAATGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCACAG...
pathogenic
246,589
Variant at chromosome position 8804828, chromosome 16, gene PMM2 (phosphomannomutase 2): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
AGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCACAGCATACACACACGCACACATACGGCTATGACTACCAGAAATGTC...
AGATCACACCATTGCACTCCAGCCTGGGCAATAAGAACGAAACTCCGTCTTGGAAAAAAAAAAAAATTATAAGTGGAGAGGTGGATGAATTGATTGTTCTTTTAACCCCTGTTGTCCCCAGAGTCCTCACATCTTGGAACCAGCTCCTCTAGAGCAAGATTTCTCACCTTCGCACTATTGATATTTTGGACCAGTTAGTTCTCCATTATGAAGGCTGTCCTGTGCATTGTAGGGTCTTTAGCAACATCCCAGGCCTCTACCCACTAGATGCCCACAGCATACACACACGCACACATACGGCTATGACTACCAGAAATGTC...
pathogenic
246,593
Evaluate the clinical significance of the mutation at chromosome 16, position 8806343 in gene PMM2 (phosphomannomutase 2): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACACCGCACCCGACCCAAAGAGCTTTTTTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTT...
GCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACACCGCACCCGACCCAAAGAGCTTTTTTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTT...
pathogenic
246,601
Is the genetic mutation found on chromosome 16 at position 8806383, within the gene PMM2 (phosphomannomutase 2), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
CACCCGACCCAAAGAGCTTTTTTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTTTCCATACTCTTCTCTTAGTCTGTAAGATGAGATAGTCTTT...
CACCCGACCCAAAGAGCTTTTTTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTTTCCATACTCTTCTCTTAGTCTGTAAGATGAGATAGTCTTT...
pathogenic
246,604
Regarding the variant found on chromosome 16 at position 8806404 in gene PMM2 (phosphomannomutase 2): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
TTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTTTCCATACTCTTCTCTTAGTCTGTAAGATGAGATAGTCTTTCACAGTCCTTGCTGGAGTTTA...
TTAAAAATATATTTAGCCTGTCCCTCAGCAATTCTGATTCAGGAAGCGAGAGAGCAAAGCTTGGAAATCTGCATTTTCACACTGCCCTGGTTGCTGCTGGTGAACCATCAGCATCATGGACGAGTATCTTCCTCTACAGACAGTCAGGCTGAAGTCAGGGACATAAGATAACCTGTCACCAAGTCCCTAATCTCCTGCCCAGTCATCATCGTTTAAATGTGTAACCAAAAAGAGCCATTAAAAAAACAAGGAACTTTTTTCCATACTCTTCTCTTAGTCTGTAAGATGAGATAGTCTTTCACAGTCCTTGCTGGAGTTTA...
pathogenic
246,608
Evaluate if the mutation on chromosome 16 at position 8811020 in PMM2 (phosphomannomutase 2) is benign or pathogenic. Disease name(s) if pathogenic?
benign
ATTTTGCTGTTTTTACTTTAATGAGTATTCATTGCTTCCCAGTTTACAAAGTACCTTTACATAACTGGCATGTTTGATTTTTAACAAGGCCCTTTGGAGGTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATA...
ATTTTGCTGTTTTTACTTTAATGAGTATTCATTGCTTCCCAGTTTACAAAGTACCTTTACATAACTGGCATGTTTGATTTTTAACAAGGCCCTTTGGAGGTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATA...
benign
246,613
Considering the variant on chromosome 16, location 8811076, involving gene PMM2 (phosphomannomutase 2), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
TTACATAACTGGCATGTTTGATTTTTAACAAGGCCCTTTGGAGGTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGT...
TTACATAACTGGCATGTTTGATTTTTAACAAGGCCCTTTGGAGGTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGT...
pathogenic
246,616
Considering the variant on chromosome 16, location 8811119, involving gene PMM2 (phosphomannomutase 2), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTT...
GTAACCAGAGCAAGTGCCATTAGCCTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTT...
pathogenic
246,627
A genetic variant at chromosome 16, position 8811143, affecting gene PMM2 (phosphomannomutase 2)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Inborn_genetic_diseases', 'PMM2-congenital_disorder_of_glycosylation']
CTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTTACAAGTTATCTGAACTTTTAAGAA...
CTTTCTGTAGGTGAATAAGAGGAGGCTTGGAGAGGTGCCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTTACAAGTTATCTGAACTTTTAAGAA...
pathogenic
246,632
Evaluate if the mutation on chromosome 16 at position 8811180 in PMM2 (phosphomannomutase 2) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
CCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTTACAAGTTATCTGAACTTTTAAGAAACTGGGTGGTTTTCTTTTTTTGGTTGTGGGGTTTTTG...
CCCAGAGCCACACAGCCTCCTAAGAGGCCACACTGACATGGAATCAGGTCATCAGCCCTGCACGTGGCATGTGGTCTCTCGGTATTTCCAATGGCCAGTGCCAGGACATCAGGTCTGTGAGATTAAAATAGTAGAAAAAGATGAGGGAAAATGTTTCATAGGGTTCCCAGGCATCAGCGTTTAGAACTGGAAGACACTTTTCACTGCATAGTTTGTCAGAAAATGCTTAAATTTCATTGGTCAGAATGATATCTAGCTTACAAGTTATCTGAACTTTTAAGAAACTGGGTGGTTTTCTTTTTTTGGTTGTGGGGTTTTTG...
pathogenic
246,638
Gene PMM2 (phosphomannomutase 2) variant at chromosome 16, position 8811635—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GGACTACAGGCATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGG...
GGACTACAGGCATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGG...
pathogenic
246,641
Gene mutation in PMM2 (phosphomannomutase 2) at chromosome 16, position 8811635—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GGACTACAGGCATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGG...
GGACTACAGGCATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGG...
pathogenic
246,642
Gene PMM2 (phosphomannomutase 2) variant at chromosome 16, position 8811646—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
ATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATC...
ATGCGCTACCATGTCCCGCTAATTTTTGTATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATC...
pathogenic
246,644
Determine if the mutation at chromosome 16, position 8811675 in gene PMM2 (phosphomannomutase 2) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
ATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATCCTCCTGTCTCAGTCTCCCAAGTAGCTGGG...
ATTTTTAGTAGGGACAGGGTTTCATCTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATCCTCCTGTCTCAGTCTCCCAAGTAGCTGGG...
pathogenic
246,648
Evaluate this variant at chromosome 16, position 8811700, gene PMM2 (phosphomannomutase 2): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
CTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATCCTCCTGTCTCAGTCTCCCAAGTAGCTGGGAATACAGGCATGTGCCACCATGCCC...
CTTGTTGGCCAGGCTGGTCTTGACTCCTGACCTCAAGGAATCCGCCCGCCGCAGCATCCCAAAGTGCTGGGATTACAGGTGTGAGCCAAAGAAACTGTTTTCAGACTCAAACTGGAAACCGTGGAAAAAAACTCTTTGTTTTTTGTTTTTTATTTTTTGTTTGTTCGTTTGTTTTTTGAGACGGGGTCTCCCTCTGTTACCCAGGCTGTAGTGCAGTGGTACGATCTTGGTTCACTGCAGCTTCCACTGCCCGGGCCCAAGCAATCCTCCTGTCTCAGTCTCCCAAGTAGCTGGGAATACAGGCATGTGCCACCATGCCC...
pathogenic
246,649
Benign or pathogenic: chromosome 16, position 8813033, gene PMM2 (phosphomannomutase 2) variant? Disease(s) if pathogenic?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
TTTTTAGAATTTCCCAAGATTTTAGGCTGTTTATCTATGTTGCCCAAATGAATAACGTGTTTTTGGAGAAACTCTGTCACCCTTTCATTCCCAGGGGTACTTTCATTGAATTCCGAAATGGGATGTTAAACGTGTCCCCTATTGGAAGAAGCTGCAGCCAAGAAGAACGCATTGAGTTCTACGAACTCGATAAAGTACGTCTTTCTGAAATATCTTTGGTGAATGGCTGGGTTTATGGAAATAAGATATGGCCTGGTGTGGTGGTTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAGCC...
TTTTTAGAATTTCCCAAGATTTTAGGCTGTTTATCTATGTTGCCCAAATGAATAACGTGTTTTTGGAGAAACTCTGTCACCCTTTCATTCCCAGGGGTACTTTCATTGAATTCCGAAATGGGATGTTAAACGTGTCCCCTATTGGAAGAAGCTGCAGCCAAGAAGAACGCATTGAGTTCTACGAACTCGATAAAGTACGTCTTTCTGAAATATCTTTGGTGAATGGCTGGGTTTATGGAAATAAGATATGGCCTGGTGTGGTGGTTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAGCC...
pathogenic
246,659
Gene PMM2 (phosphomannomutase 2) variant at chromosome 16, position 8813050—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['PMM2-congenital_disorder_of_glycosylation']
GATTTTAGGCTGTTTATCTATGTTGCCCAAATGAATAACGTGTTTTTGGAGAAACTCTGTCACCCTTTCATTCCCAGGGGTACTTTCATTGAATTCCGAAATGGGATGTTAAACGTGTCCCCTATTGGAAGAAGCTGCAGCCAAGAAGAACGCATTGAGTTCTACGAACTCGATAAAGTACGTCTTTCTGAAATATCTTTGGTGAATGGCTGGGTTTATGGAAATAAGATATGGCCTGGTGTGGTGGTTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAG...
GATTTTAGGCTGTTTATCTATGTTGCCCAAATGAATAACGTGTTTTTGGAGAAACTCTGTCACCCTTTCATTCCCAGGGGTACTTTCATTGAATTCCGAAATGGGATGTTAAACGTGTCCCCTATTGGAAGAAGCTGCAGCCAAGAAGAACGCATTGAGTTCTACGAACTCGATAAAGTACGTCTTTCTGAAATATCTTTGGTGAATGGCTGGGTTTATGGAAATAAGATATGGCCTGGTGTGGTGGTTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAG...
pathogenic
246,662
Chromosome 16, position 8894529, gene USP7 (ubiquitin specific peptidase 7): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
ATAGCGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAA...
ATAGCGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAA...
benign
246,702
Does the chromosome 16 mutation at position 8894529 within gene USP7 (ubiquitin specific peptidase 7) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
ATAGCGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAA...
ATAGCGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAA...
benign
246,703
Assess the variant on chromosome 16, position 8894533, impacting USP7 (ubiquitin specific peptidase 7): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
benign
CGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAACATA...
CGCCTGCCGCCCCGAAGGGCCTCGTGACACATCAGGTCACATCTCCAGTCACCTTATTTGTACACAGTTCTCTCCTGGAAAACCTTTCATTTCTTAAGAGTAAATGTGACTAGTTAGAGGCTAAAAAAAAAAAAAAAAAAAAAAAGAAACAAGAGACCCTGCCCCCGCAAAACGGAATTAGAAGGAAAAGTACATCTCAGTGAAACCTTGTTACAAATGCCAAGGTTTCCCAGGCCTGTTTCCAGGGAGAGTAGAAATCTTCCTCCACTTCCACGTAACTCACTGAATTATAATTTTTATAGAAAATTTTATTCAACATA...
benign
246,704
Considering the variant on chromosome 16, location 9763522, involving gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Landau-Kleffner_syndrome']
ATCCCAAATACTTCAAAAATATTCATGTACATGAAATACACTAATTAACAGAGTAGAACTATATAAAAGGTTTAGTTAATATTATTTGCTGGTTTTATGATATTTAATTTTTAAACTAGAAAATCCTGATCTGAGAAAGTGTCATAACATAGCAACTATCTTGTCGGGGGCACTTGTTTTTGTGGCAGGCACTGTGCTAACAGGCTCCCCATGCATAAGTATTCCCCTCTCTGTCTCTAACTTAAAAAAAAAATGGATATCATTTCATGTCATATATGCACAGGTTTGAGGAGAATAAGAATGGGATAATGCAGGCGACT...
ATCCCAAATACTTCAAAAATATTCATGTACATGAAATACACTAATTAACAGAGTAGAACTATATAAAAGGTTTAGTTAATATTATTTGCTGGTTTTATGATATTTAATTTTTAAACTAGAAAATCCTGATCTGAGAAAGTGTCATAACATAGCAACTATCTTGTCGGGGGCACTTGTTTTTGTGGCAGGCACTGTGCTAACAGGCTCCCCATGCATAAGTATTCCCCTCTCTGTCTCTAACTTAAAAAAAAAATGGATATCATTTCATGTCATATATGCACAGGTTTGAGGAGAATAAGAATGGGATAATGCAGGCGACT...
pathogenic
246,759
The chromosome 16, position 9798268 genetic variant in gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Landau-Kleffner_syndrome']
TTAAAAGTTTCCAGCCAAATGAAATACATCTTAACATCAATCAATCATTCATCCATACATGTATTTATTCATTCAAACCTTTATTGACCAATTTACCTGTGATGTTCAGTGTTTTGTTGTAATGCTGGAAATAAGACTCCTGTTTGCTGAATAGTTCATCCCCTGTAAGGGTGATTATCCACCCCTGTGATAGGCAAAACATTTGGCCCCAATTCTTCAGCATACTCTCAGTGTCCACACTATTGCCATAAAACTTCAAGACCTATCTCATGAAAGGCAGAGTATACCTGCAATCCCTTGACCCTGAACTTGGCCACCTG...
TTAAAAGTTTCCAGCCAAATGAAATACATCTTAACATCAATCAATCATTCATCCATACATGTATTTATTCATTCAAACCTTTATTGACCAATTTACCTGTGATGTTCAGTGTTTTGTTGTAATGCTGGAAATAAGACTCCTGTTTGCTGAATAGTTCATCCCCTGTAAGGGTGATTATCCACCCCTGTGATAGGCAAAACATTTGGCCCCAATTCTTCAGCATACTCTCAGTGTCCACACTATTGCCATAAAACTTCAAGACCTATCTCATGAAAGGCAGAGTATACCTGCAATCCCTTGACCCTGAACTTGGCCACCTG...
pathogenic
246,829
Regarding the variant at chromosome 16 and position 9829483, affecting gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Landau-Kleffner_syndrome']
GGGGAGAAATCAAGGGTCTGATTTAAGGCCAAGTCTCCATCTCAGTCCCGTCCTGCAGGGAGCTCCAGAGAGTGATTCGTACCTTAAAGTTTTTCCTGCTTCGAAGCAAGGGAGCAGCTTAGCCTTTGTATTCTCACACAGATTAGTCTTTGGTTACAGGTGACCACAAAGATTGAGGGAACTTAAATTGCCAGGCATTTACCATTCCAGTGCCCAAAGGCAAAAATCTGCTGAGGATCCCTGAAGTGAGGCTTTGTCAGCAAAGCACAGAAAGGTGGGGCTGGGCACACAGCGCTGCAAAAGGGATCCCAGGAGATCCA...
GGGGAGAAATCAAGGGTCTGATTTAAGGCCAAGTCTCCATCTCAGTCCCGTCCTGCAGGGAGCTCCAGAGAGTGATTCGTACCTTAAAGTTTTTCCTGCTTCGAAGCAAGGGAGCAGCTTAGCCTTTGTATTCTCACACAGATTAGTCTTTGGTTACAGGTGACCACAAAGATTGAGGGAACTTAAATTGCCAGGCATTTACCATTCCAGTGCCCAAAGGCAAAAATCTGCTGAGGATCCCTGAAGTGAGGCTTTGTCAGCAAAGCACAGAAAGGTGGGGCTGGGCACACAGCGCTGCAAAAGGGATCCCAGGAGATCCA...
pathogenic
246,862
Does the chromosome 16 mutation at position 9834189 within gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Landau-Kleffner_syndrome']
AGATGAGGTCTTGCTATGTTACCCAGGCTGGTCTCAAACTCCTGACCTCAGGCAATTCTCCTGCCTTGGCCTCAAAAAGCCTTGACATCACAAGTATGAGCCACTGCACCCCCTCAGCCTTTTTCTGTTTCTTGAGCATCTCAAGATTATTTCAGCCTTTCTGTTTGCTGTTCCTTTTACATGAAATGACTGTAACTGTTTTTGACAGATAAAATTGTATGTCACCCTTCAGGTCCTAGCTCAATGAACATCCTTTCCCATTGGACCATCTTATCTAACGTAGTGTCTGCACCCCATCACTATCATGTCACTATGTTTTT...
AGATGAGGTCTTGCTATGTTACCCAGGCTGGTCTCAAACTCCTGACCTCAGGCAATTCTCCTGCCTTGGCCTCAAAAAGCCTTGACATCACAAGTATGAGCCACTGCACCCCCTCAGCCTTTTTCTGTTTCTTGAGCATCTCAAGATTATTTCAGCCTTTCTGTTTGCTGTTCCTTTTACATGAAATGACTGTAACTGTTTTTGACAGATAAAATTGTATGTCACCCTTCAGGTCCTAGCTCAATGAACATCCTTTCCCATTGGACCATCTTATCTAACGTAGTGTCTGCACCCCATCACTATCATGTCACTATGTTTTT...
pathogenic
246,873
The mutation in gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A) at chromosome 16, position 9841070—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Landau-Kleffner_syndrome']
CAAAAATCACTTGTACCCCTGAGCTATTGAAATTTTTTAAAAATTATACATATTTTTCCCCTCTCAGTTTTCCTCCAGAGATTCACGTTTGTCTTAACCTTCCCTAATTTGGGACAAACCCACTTATATGGGAGTGCCAAGGGGGAATTAGTGATCTGAATTTCATGATATTCAACAAGATAGTTACAGTCAAAACTCATTTATGATAACCAAACAGTTAATACAACACTTTCCTTTAAAGACAAAAATAATGCTTTACTATGTTCCATGAAATTTCAACTCTAGCCAGGCTACCCAATACAGTCCAAGTGCTAGAGAAA...
CAAAAATCACTTGTACCCCTGAGCTATTGAAATTTTTTAAAAATTATACATATTTTTCCCCTCTCAGTTTTCCTCCAGAGATTCACGTTTGTCTTAACCTTCCCTAATTTGGGACAAACCCACTTATATGGGAGTGCCAAGGGGGAATTAGTGATCTGAATTTCATGATATTCAACAAGATAGTTACAGTCAAAACTCATTTATGATAACCAAACAGTTAATACAACACTTTCCTTTAAAGACAAAAATAATGCTTTACTATGTTCCATGAAATTTCAACTCTAGCCAGGCTACCCAATACAGTCCAAGTGCTAGAGAAA...
pathogenic
246,902
Clinical impact (benign or pathogenic) of the variant at chromosome 16, location 9938217, gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A): what disease(s) if pathogenic?
pathogenic; ['Landau-Kleffner_syndrome']
ACATCAACATCACCCAAAAACTTGAAAGAAATTGCAAATTCTCTGGGCTCACCCCATATTTTCTATTACATTAGAAACTCTGAGATTGAGGCCCAGTAATTTGTGTCTTAACAAGTCCTCCCAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTC...
ACATCAACATCACCCAAAAACTTGAAAGAAATTGCAAATTCTCTGGGCTCACCCCATATTTTCTATTACATTAGAAACTCTGAGATTGAGGCCCAGTAATTTGTGTCTTAACAAGTCCTCCCAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTC...
pathogenic
246,939
For chromosome 16, position 9938235, gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Intellectual_disability', 'Landau-Kleffner_syndrome']
AACTTGAAAGAAATTGCAAATTCTCTGGGCTCACCCCATATTTTCTATTACATTAGAAACTCTGAGATTGAGGCCCAGTAATTTGTGTCTTAACAAGTCCTCCCAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTCATTATCTGAGGAATAAAG...
AACTTGAAAGAAATTGCAAATTCTCTGGGCTCACCCCATATTTTCTATTACATTAGAAACTCTGAGATTGAGGCCCAGTAATTTGTGTCTTAACAAGTCCTCCCAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTCATTATCTGAGGAATAAAG...
pathogenic
246,941
Gene mutation in GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A) at chromosome 16, position 9938338—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Landau-Kleffner_syndrome']
CAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTCATTATCTGAGGAATAAAGCGTGGATTAAATCAGTGAACATCAGGCAAAACCATGCAAAATTGGGATAGGAGTGATCATTCTAAATCTCAACAGCTGAACCATAATGATGGGCCACAAGGAA...
CAGAGATTCTGATGCCTGCTGAGGCTTGAGAACCACTGCCTAGAAATTAGGTGCTATTATCATCACTTTGCAATAAACACCTGAGGCCCAGAAAAGTAAAATGATGTGCAAGTCATACAGAAAGTGGACGAGACAAGCTTTGAACCCAGACAAGTCTAACTCCAGAGTTGAGGCCCTTAATCACAGTTCTACACTGCTCATTATCTGAGGAATAAAGCGTGGATTAAATCAGTGAACATCAGGCAAAACCATGCAAAATTGGGATAGGAGTGATCATTCTAAATCTCAACAGCTGAACCATAATGATGGGCCACAAGGAA...
pathogenic
246,945
The chromosome 16, position 10180315 genetic variant in gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Inborn_genetic_diseases', 'Landau-Kleffner_syndrome']
GCTCAGCCCCTCCCACAAAATGAAACTGATCCCTTGTCCCTCCTGAAGATGGATGACATCATTAAAGTATGGGCTTGATTTAGTGGAATGGAAGATCACACCTTGGGATCAGAAATTCAGCTACCTAGCTACATCAGCCACTATGTGGTCTTGGCAAATTCCCTTAACTCCCCTATGGCTCAGTCACTTCATCTGAAAGTTACAGCATGCTCCAAGAAACCCTAAGATGCTCTCCAGTTCTGAAATTGTCAGTGGTGGCAGAGCATGGCTAGTCCCTACTCTCTTCTTCCCAGACAGGAGCCCCCCAAAACTGAGAAGTG...
GCTCAGCCCCTCCCACAAAATGAAACTGATCCCTTGTCCCTCCTGAAGATGGATGACATCATTAAAGTATGGGCTTGATTTAGTGGAATGGAAGATCACACCTTGGGATCAGAAATTCAGCTACCTAGCTACATCAGCCACTATGTGGTCTTGGCAAATTCCCTTAACTCCCCTATGGCTCAGTCACTTCATCTGAAAGTTACAGCATGCTCCAAGAAACCCTAAGATGCTCTCCAGTTCTGAAATTGTCAGTGGTGGCAGAGCATGGCTAGTCCCTACTCTCTTCTTCCCAGACAGGAGCCCCCCAAAACTGAGAAGTG...
pathogenic
246,971
For chromosome 16, position 10898709, gene CIITA (class II major histocompatibility complex transactivator): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['MHC_class_II_deficiency', 'MHC_class_II_deficiency_1', 'Rheumatoid_arthritis']
GTGCAAGCCGGAGTCCTGCCCCCATTTTCCTTGTTGGCTTGGGCACCTGTGTGCAGTGAACAACCTGCAAAACTCTTCTTAGTGGTCTTCTTCCTGCCAACCCAGGAACAGCAGCATTCAGCAGTTCTGTGCTTGATCCAAATGTGGCCAATTTTTCCCCAGAGCACAGTGTATTGAAAATCATACCAAGGAAGAAAATGGAGGGGACTAGTAATTGTTCATGTTTCAGAAATTACAGAACTGAGAGCTTGACTGCTTCCTTCCCTTCCTGGGGATTTACATGGGGGAAGCAGAAGTGATTGGGGCTGAGGACATTCACA...
GTGCAAGCCGGAGTCCTGCCCCCATTTTCCTTGTTGGCTTGGGCACCTGTGTGCAGTGAACAACCTGCAAAACTCTTCTTAGTGGTCTTCTTCCTGCCAACCCAGGAACAGCAGCATTCAGCAGTTCTGTGCTTGATCCAAATGTGGCCAATTTTTCCCCAGAGCACAGTGTATTGAAAATCATACCAAGGAAGAAAATGGAGGGGACTAGTAATTGTTCATGTTTCAGAAATTACAGAACTGAGAGCTTGACTGCTTCCTTCCCTTCCTGGGGATTTACATGGGGGAAGCAGAAGTGATTGGGGCTGAGGACATTCACA...
pathogenic
247,006
Assess the variant on chromosome 16, position 10902659, impacting CIITA (class II major histocompatibility complex transactivator): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['MHC_class_II_deficiency', 'MHC_class_II_deficiency_1', 'Rheumatoid_arthritis']
ACACCTGTAATCCCAGCTACCAGGGAGGCTAGGGTGGGAGAATCGCTTGAACCTAAGAAGCAGAGGTTGCAGTGAGCCAAGATTGCGCCAGTGCACTCCAGCCTGGGCAACAGAGCTAGACTCTGTTTCAAAAAAAAAAAAAAATGTTTTCAAGATACAATAAAAGTGAAAGAATGGTACTATGAAGGTCCATATACCCACCATGTACCATTTTGATTCTACAATTAATGTTGGGTTTTATTCATCTTATCACATCTCTATTCATCTGTCCATCCCTCTATCCATCCACACACCCATTCATTATATTTTTGGTACATTTC...
ACACCTGTAATCCCAGCTACCAGGGAGGCTAGGGTGGGAGAATCGCTTGAACCTAAGAAGCAGAGGTTGCAGTGAGCCAAGATTGCGCCAGTGCACTCCAGCCTGGGCAACAGAGCTAGACTCTGTTTCAAAAAAAAAAAAAAATGTTTTCAAGATACAATAAAAGTGAAAGAATGGTACTATGAAGGTCCATATACCCACCATGTACCATTTTGATTCTACAATTAATGTTGGGTTTTATTCATCTTATCACATCTCTATTCATCTGTCCATCCCTCTATCCATCCACACACCCATTCATTATATTTTTGGTACATTTC...
pathogenic
247,015
A mutation at chromosome position 10907447 on chromosome 16 in gene CIITA (class II major histocompatibility complex transactivator): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['MHC_class_II_deficiency']
CCCATGACCTCCCCATGGTGAGTGAGTAGTGATCAAGCGAAGAAAAAGCTTAGTGAGTAAATGAAGGAATGAGAAAAGATGGCCATGCATGGTGCCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCCATTAAAAAATACAAAAATTAGCCAGACGTGGTAGTGGGTGCCTGTAATCCCAGCTACTTGGCAGGCCGAGGCAGGAGAATCGCCTAAACCCAGGAGGTGGAGGTTGCCGTGAGCTGAGATTGC...
CCCATGACCTCCCCATGGTGAGTGAGTAGTGATCAAGCGAAGAAAAAGCTTAGTGAGTAAATGAAGGAATGAGAAAAGATGGCCATGCATGGTGCCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCCATTAAAAAATACAAAAATTAGCCAGACGTGGTAGTGGGTGCCTGTAATCCCAGCTACTTGGCAGGCCGAGGCAGGAGAATCGCCTAAACCCAGGAGGTGGAGGTTGCCGTGAGCTGAGATTGC...
pathogenic
247,025
Is the genetic mutation found on chromosome 16 at position 10907780, within the gene CIITA (class II major histocompatibility complex transactivator), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['MHC_class_II_deficiency', 'MHC_class_II_deficiency_1', 'Rheumatoid_arthritis']
AGCCTGGGGCACAGGGCAGGATCCATCTCAAAAAAAAAAAAGAGAGAAAAGGTCTAAAAGGAGTGGACACTTAAACAAGAGAGACGATGAGTGAAGGAATGGGTGTGGAAATGAGTGAACTAATGAATGAGTGGTGGGTGACTGAATGAAGCAAATGATGAAGACTGTATGGGGGCCAGATGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGAACGATTGCTTGAGCCCAGGAGCTCAAGACCAGCCTGGGCAAAATAGTGAGAACTTATCTCCACAAAAAAACAAAAAAGAAAAATTAGCCAG...
AGCCTGGGGCACAGGGCAGGATCCATCTCAAAAAAAAAAAAGAGAGAAAAGGTCTAAAAGGAGTGGACACTTAAACAAGAGAGACGATGAGTGAAGGAATGGGTGTGGAAATGAGTGAACTAATGAATGAGTGGTGGGTGACTGAATGAAGCAAATGATGAAGACTGTATGGGGGCCAGATGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGAACGATTGCTTGAGCCCAGGAGCTCAAGACCAGCCTGGGCAAAATAGTGAGAACTTATCTCCACAAAAAAACAAAAAAGAAAAATTAGCCAG...
pathogenic
247,029
Is the genetic variant on chromosome 16, position 11254998, gene SOCS1 (suppressor of cytokine signaling 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autoimmune_hemolytic_anemia', 'Autoimmune_thrombocytopenia', 'Autoinflammatory_syndrome_with_immunodeficiency']
AGTATTACAACCAGATCCCCAAGCATTGCCATCTTGGATTTCTGTTTCTCCAGACACTGCCCACAGCAGGCAACAGACAGGAAAGAACAAGGACAGGACTTAATTAATCCACAGCAGAGAAGAAAGGGCAGGGGTGTGGCAAAAAAAAAAAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAAAGCAAGATTTTTGGAGATAGAGACAAGACATCACCTCCTTCCCTCCCACTTCACCTTATTAAGGGATGAAATTGCCAAAGCTCTCTGAGATCCTAAATCTCTTCTGGCCATCCTTAAAGTCCTGGAGCCTACTTAAT...
AGTATTACAACCAGATCCCCAAGCATTGCCATCTTGGATTTCTGTTTCTCCAGACACTGCCCACAGCAGGCAACAGACAGGAAAGAACAAGGACAGGACTTAATTAATCCACAGCAGAGAAGAAAGGGCAGGGGTGTGGCAAAAAAAAAAAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAAAGCAAGATTTTTGGAGATAGAGACAAGACATCACCTCCTTCCCTCCCACTTCACCTTATTAAGGGATGAAATTGCCAAAGCTCTCTGAGATCCTAAATCTCTTCTGGCCATCCTTAAAGTCCTGGAGCCTACTTAAT...
pathogenic
247,066
Does the genetic variant at chromosome 16, position 11586204, impacting gene LITAF (lipopolysaccharide induced TNF factor), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
CTAAAGAAACACAGAACTAAGGAAGTCTATTTACCTGATAGACCGCCTCACCCACGGGGCTATTTTCACTGCTGTAAAAGCGAAAACAAATAGAGGACAAGTCACAGTGCCAAGAATACAGGACTTCCTCTTGCAGATCCTCTTTTTTCCACCCTCACTGTAGCTCTGGGGAAATTCCTATTCAGTGGGAGAAGTTTAAGTCACAAAACGGCACCAGCCCATTCTCAAAGTGCTATTATACACCTCTGAGCAGTGAGGATGGGTAATGTCAGCAAAATATGCACTGTTTATTTTCTTGAAAATTAACTTGGGCTGGAAAC...
CTAAAGAAACACAGAACTAAGGAAGTCTATTTACCTGATAGACCGCCTCACCCACGGGGCTATTTTCACTGCTGTAAAAGCGAAAACAAATAGAGGACAAGTCACAGTGCCAAGAATACAGGACTTCCTCTTGCAGATCCTCTTTTTTCCACCCTCACTGTAGCTCTGGGGAAATTCCTATTCAGTGGGAGAAGTTTAAGTCACAAAACGGCACCAGCCCATTCTCAAAGTGCTATTATACACCTCTGAGCAGTGAGGATGGGTAATGTCAGCAAAATATGCACTGTTTATTTTCTTGAAAATTAACTTGGGCTGGAAAC...
benign
247,124
Does the variant on chromosome 16 at location 13926725 affecting gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'Xeroderma_pigmentosum,_group_F']
CGTACATTGGTGATAAAGATAGTACCTTCCTCCTAGGATTGTCAGGGTGAAATGAAATGCTTATATGTAAAATACTTGGTAGCATGGCACATAGTCAGCATTCTATGATCTCTGTGATCTCTGCCTGTTGGTGTTACGATGTTCCTGTTCTCGGGCAGTTTAATGGAGGAGACAAGTAAAGAAGTAGTTATAGTACAGTATGGGTACAAAATGTCATAGGAACAAAAAAAACTAAAGTAGGCTTTTGTGGAGCTAAAACTCCTCCCAAAAACCTAACCTGCTTCTATTATTTTTATTTTTTGAAAAAGGAGTGTCTTGAG...
CGTACATTGGTGATAAAGATAGTACCTTCCTCCTAGGATTGTCAGGGTGAAATGAAATGCTTATATGTAAAATACTTGGTAGCATGGCACATAGTCAGCATTCTATGATCTCTGTGATCTCTGCCTGTTGGTGTTACGATGTTCCTGTTCTCGGGCAGTTTAATGGAGGAGACAAGTAAAGAAGTAGTTATAGTACAGTATGGGTACAAAATGTCATAGGAACAAAAAAAACTAAAGTAGGCTTTTGTGGAGCTAAAACTCCTCCCAAAAACCTAACCTGCTTCTATTATTTTTATTTTTTGAAAAAGGAGTGTCTTGAG...
pathogenic
247,143
Gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) variant at chromosome 16, position 13930831—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'XFE_progeroid_syndrome', 'Xeroderma_pigmentosum,_group_F']
GATTAATATTATTACAGATACATAAACGTCTAGTATTGAATTGGAGATCCAGAAAATGCTGACCTTTTAGAAATTCTTGGCAGCCTTTTTGTCATATTCTGGTAGAAAAAGTTTCTGTCTTTTAAACTCTGAGTCAATCTCTATGTCACTGGCAATAATGCGTGGCGATTATAAAAAAGGAAAAAATTGACTTATTTCTCTGATTCTTCAAAAAAGTCAGTTGACTATGAATATTGATACATAAAACTAATTTTATATATTCTGTTCCTCTGTGCTTAAAGTTTTTTATGATTTAGTCCATGGTGATTTTTTTTAAATCC...
GATTAATATTATTACAGATACATAAACGTCTAGTATTGAATTGGAGATCCAGAAAATGCTGACCTTTTAGAAATTCTTGGCAGCCTTTTTGTCATATTCTGGTAGAAAAAGTTTCTGTCTTTTAAACTCTGAGTCAATCTCTATGTCACTGGCAATAATGCGTGGCGATTATAAAAAAGGAAAAAATTGACTTATTTCTCTGATTCTTCAAAAAAGTCAGTTGACTATGAATATTGATACATAAAACTAATTTTATATATTCTGTTCCTCTGTGCTTAAAGTTTTTTATGATTTAGTCCATGGTGATTTTTTTTAAATCC...
pathogenic
247,151
A genetic alteration at chromosome 16, position 13930854, in gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'XFE_progeroid_syndrome', 'Xeroderma_pigmentosum,_group_F']
AAACGTCTAGTATTGAATTGGAGATCCAGAAAATGCTGACCTTTTAGAAATTCTTGGCAGCCTTTTTGTCATATTCTGGTAGAAAAAGTTTCTGTCTTTTAAACTCTGAGTCAATCTCTATGTCACTGGCAATAATGCGTGGCGATTATAAAAAAGGAAAAAATTGACTTATTTCTCTGATTCTTCAAAAAAGTCAGTTGACTATGAATATTGATACATAAAACTAATTTTATATATTCTGTTCCTCTGTGCTTAAAGTTTTTTATGATTTAGTCCATGGTGATTTTTTTTAAATCCCACACAATCTTTTAATAGAATGT...
AAACGTCTAGTATTGAATTGGAGATCCAGAAAATGCTGACCTTTTAGAAATTCTTGGCAGCCTTTTTGTCATATTCTGGTAGAAAAAGTTTCTGTCTTTTAAACTCTGAGTCAATCTCTATGTCACTGGCAATAATGCGTGGCGATTATAAAAAAGGAAAAAATTGACTTATTTCTCTGATTCTTCAAAAAAGTCAGTTGACTATGAATATTGATACATAAAACTAATTTTATATATTCTGTTCCTCTGTGCTTAAAGTTTTTTATGATTTAGTCCATGGTGATTTTTTTTAAATCCCACACAATCTTTTAATAGAATGT...
pathogenic
247,152
The chromosome 16, position 13934285 genetic variant in gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'Xeroderma_pigmentosum,_group_F']
AGTAAAAAAGAAAAAATATCTGAAAAAATGGAAATTAAAGAAGGGGAAGGTATCTTGTGGGGTTAAGTCTTTAAATGTGTTTTTTATTTCGGTATTTGGTATGGAAATTTAAAGTGCAATTTAAAGTCTTCTTTGGCCATGTGAAAAGTGTGTTCCTTGAAGATAAATGTATGTATGTTTGTTATATGTAACATGTAATGTATGTTGAAAGTATATATGTAAAGTATATGTGTAATGTATGTCGAAGTATACAGCATGGCAAGTCTTGCAGTCTATTGCCCAGGGCTTCCAAATAACAGATGTCAAATATTGATCAAAAG...
AGTAAAAAAGAAAAAATATCTGAAAAAATGGAAATTAAAGAAGGGGAAGGTATCTTGTGGGGTTAAGTCTTTAAATGTGTTTTTTATTTCGGTATTTGGTATGGAAATTTAAAGTGCAATTTAAAGTCTTCTTTGGCCATGTGAAAAGTGTGTTCCTTGAAGATAAATGTATGTATGTTTGTTATATGTAACATGTAATGTATGTTGAAAGTATATATGTAAAGTATATGTGTAATGTATGTCGAAGTATACAGCATGGCAAGTCTTGCAGTCTATTGCCCAGGGCTTCCAAATAACAGATGTCAAATATTGATCAAAAG...
pathogenic
247,163
Does the genetic variant at chromosome 16, position 13935330, impacting gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'XFE_progeroid_syndrome', 'Xeroderma_pigmentosum,_group_F']
AAATATACTAGAATGAGGCAAATATGGGTTTTATTCCAGCATCTTATCTAGTGATACCGTAAATATCACTAGTTTTTTAAGGCATGGGATAGGGTTAATGCCTGCTTTCTGCCTAGTTTAAAGGTCTGTTTCAAAACTTAACTGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGTACTTTGGGAAGCCAGTGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAATCCTCTCTCTACTAAAAATACAAAATTAGCCAGGAGTGGTGGCACATGCCTGTAATCCCAGCTACTTG...
AAATATACTAGAATGAGGCAAATATGGGTTTTATTCCAGCATCTTATCTAGTGATACCGTAAATATCACTAGTTTTTTAAGGCATGGGATAGGGTTAATGCCTGCTTTCTGCCTAGTTTAAAGGTCTGTTTCAAAACTTAACTGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGTACTTTGGGAAGCCAGTGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAATCCTCTCTCTACTAAAAATACAAAATTAGCCAGGAGTGGTGGCACATGCCTGTAATCCCAGCTACTTG...
pathogenic
247,168
The chromosome 16, position 13935413 genetic variant in gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'Precursor_B-cell_acute_lymphoblastic_leukemia', 'Xeroderma_pigmentosum,_group_F']
ATGGGATAGGGTTAATGCCTGCTTTCTGCCTAGTTTAAAGGTCTGTTTCAAAACTTAACTGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGTACTTTGGGAAGCCAGTGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAATCCTCTCTCTACTAAAAATACAAAATTAGCCAGGAGTGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGACTTGCTTGAACCCAGGAGGCAGAGGTTGCAACGAGCCGAGATCATGCCATTGCCTCCAGCCTGGG...
ATGGGATAGGGTTAATGCCTGCTTTCTGCCTAGTTTAAAGGTCTGTTTCAAAACTTAACTGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGTACTTTGGGAAGCCAGTGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAATCCTCTCTCTACTAAAAATACAAAATTAGCCAGGAGTGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGACTTGCTTGAACCCAGGAGGCAGAGGTTGCAACGAGCCGAGATCATGCCATTGCCTCCAGCCTGGG...
pathogenic
247,170
Classify the chromosome 16 variant at position 13935661 affecting gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Cockayne_syndrome', 'Fanconi_anemia_complementation_group_Q', 'Spastic_ataxia', 'Xeroderma_pigmentosum,_group_F', 'Xeroderma_pigmentosum,_type_F/Cockayne_syndrome']
CAGGAGACTTGCTTGAACCCAGGAGGCAGAGGTTGCAACGAGCCGAGATCATGCCATTGCCTCCAGCCTGGGCAGTAAGAGTGAAACTTCGTCTTAAAAAAAAAAAATCTTTTTAAAGAAAACTTAATTGAATATATTATTGATGTGTTTGTGTTTGAATGCGTATAGGAACAAAAAATTTAATTGTTGTCTACTTTTATCCATGTTCAGGATTATGAAAGTCATGGGGATTTTAGAAATAGTAAATACTGTCATTGTGTACCGATGCCTTTGTTTTGTATAGCTGCTTATATATAGTGTCACAGAAACAACTAACACAG...
CAGGAGACTTGCTTGAACCCAGGAGGCAGAGGTTGCAACGAGCCGAGATCATGCCATTGCCTCCAGCCTGGGCAGTAAGAGTGAAACTTCGTCTTAAAAAAAAAAAATCTTTTTAAAGAAAACTTAATTGAATATATTATTGATGTGTTTGTGTTTGAATGCGTATAGGAACAAAAAATTTAATTGTTGTCTACTTTTATCCATGTTCAGGATTATGAAAGTCATGGGGATTTTAGAAATAGTAAATACTGTCATTGTGTACCGATGCCTTTGTTTTGTATAGCTGCTTATATATAGTGTCACAGAAACAACTAACACAG...
pathogenic
247,172
The mutation in gene ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) at chromosome 16, position 13950918—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
TTGTGTAGGAAATCATGTTCTGACCCTTTGTCTACAAAGGAGCCTTCTGGAACACTGAGAAGAAACATCTCTTTGCCATTCCTGACCAGTTCTCTCTACCACATTTTCTTCAGCTCCATACTTCTGCCTGTCTGCTCTAAGGAAATTTCATGGAGCCTTCCTACTACTAATTCAAGACAGTCTCCTCAAAAACTGGTTGACTAGTCTTCTAATGACCCTAACATATGTAGCATATACTATAATTTCATTGTTCCAAATTAGTATTTTTAAAGCAAAATGAATTACCTGTTTGCAAAAGTTAATGATGAAGGAGCTCTTAG...
TTGTGTAGGAAATCATGTTCTGACCCTTTGTCTACAAAGGAGCCTTCTGGAACACTGAGAAGAAACATCTCTTTGCCATTCCTGACCAGTTCTCTCTACCACATTTTCTTCAGCTCCATACTTCTGCCTGTCTGCTCTAAGGAAATTTCATGGAGCCTTCCTACTACTAATTCAAGACAGTCTCCTCAAAAACTGGTTGACTAGTCTTCTAATGACCCTAACATATGTAGCATATACTATAATTTCATTGTTCCAAATTAGTATTTTTAAAGCAAAATGAATTACCTGTTTGCAAAAGTTAATGATGAAGGAGCTCTTAG...
benign
247,208
Does the genetic variant at chromosome 16, position 14447001, impacting gene PARN (poly(A)-specific ribonuclease), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Dyskeratosis_congenita,_autosomal_recessive_6', 'Pulmonary_fibrosis', 'Pulmonary_fibrosis_and/or_bone_marrow_failure,_Telomere-related,_4']
GGACTACATGCCCGTGCAGCTAATATTTAAATTTTTTTTTTTTTTTTTTTTTTTTTGTAGAGAAAAGGTGTCACTATATTGCCCAGGCTGGTCTCAAACTCCCGGGCTCAGGTCATCCTCCTGCTTCAGCTTCCCAGAGTGGTGGGATTATAGTTGTGAGCTACCATGCCTGGCCCCCTCCAATAGTTAAGTCAGGGAAAGGACAGGAGGTAAGTAAAGAGAGACACCCAGAGTCAAGAGACAGCTAAAACATCCAATCCAGGCTTCAAACACAAGTTTAAGTTTTCTGTTGAAATTCAGCTTCAGCATAATGTACAAAA...
GGACTACATGCCCGTGCAGCTAATATTTAAATTTTTTTTTTTTTTTTTTTTTTTTTGTAGAGAAAAGGTGTCACTATATTGCCCAGGCTGGTCTCAAACTCCCGGGCTCAGGTCATCCTCCTGCTTCAGCTTCCCAGAGTGGTGGGATTATAGTTGTGAGCTACCATGCCTGGCCCCCTCCAATAGTTAAGTCAGGGAAAGGACAGGAGGTAAGTAAAGAGAGACACCCAGAGTCAAGAGACAGCTAAAACATCCAATCCAGGCTTCAAACACAAGTTTAAGTTTTCTGTTGAAATTCAGCTTCAGCATAATGTACAAAA...
pathogenic
247,224