question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Located at chromosome 17 position 1361317, the variant affecting gene YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
ATGAGTGCACAACTGCAGAGACAGAACAAGATCCTGTCCGGAAAAAAAAGTTACCCACAGAATTTTCAGTCCCAATTCCACCTCAAGGTGAAGTTAAATACAAGGACTCAAGCAAATACTTAGTGCACCCATTTTCATAGCAGCATTGTACTCACCATAGGGAAAAGGTGGAAACCCACTGACCACCAAAAGTTTAATGACTAAACAATGTGTGCAAAATACATAAAATGAATTGTGTAAATTCAGTCACTAAAAGGACTGAAGCTCTGATCCATGCTTTTACATGGATAAAAACATTACGCTAGATGAAATAAAGACAG...
ATGAGTGCACAACTGCAGAGACAGAACAAGATCCTGTCCGGAAAAAAAAGTTACCCACAGAATTTTCAGTCCCAATTCCACCTCAAGGTGAAGTTAAATACAAGGACTCAAGCAAATACTTAGTGCACCCATTTTCATAGCAGCATTGTACTCACCATAGGGAAAAGGTGGAAACCCACTGACCACCAAAAGTTTAATGACTAAACAATGTGTGCAAAATACATAAAATGAATTGTGTAAATTCAGTCACTAAAAGGACTGAAGCTCTGATCCATGCTTTTACATGGATAAAAACATTACGCTAGATGAAATAAAGACAG...
benign
260,391
Is chromosome 17, position 1362010, gene YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
GAGAGAGAGAGAGAGATTTGAAAAAAAGTCTCACTGTGTCACCCAGGCTACAGTGTACTGGTGCAATCGAGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAACAATTCTCCTGTCTCAGCCTCCCGAGTAACTGGGATTGCAGGCATGCACCACCACACCCGGCTAATTTTGTATTTTTAATAGAGACAGAGTTTCACCATGTTGGTCAGGTTGGTATCGAACTCCTGATCTCAGGTGACCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCAGGCTATCACAACTTTTTAAAAGT...
GAGAGAGAGAGAGAGATTTGAAAAAAAGTCTCACTGTGTCACCCAGGCTACAGTGTACTGGTGCAATCGAGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAACAATTCTCCTGTCTCAGCCTCCCGAGTAACTGGGATTGCAGGCATGCACCACCACACCCGGCTAATTTTGTATTTTTAATAGAGACAGAGTTTCACCATGTTGGTCAGGTTGGTATCGAACTCCTGATCTCAGGTGACCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCAGGCTATCACAACTTTTTAAAAGT...
benign
260,394
The genetic variant at chromosome 17, position 1509161, affecting gene INPP5K (inositol polyphosphate-5-phosphatase K): benign or pathogenic? Disease name(s) if pathogenic?
benign
GTCTCCCAGTAGTCTCGACCCAGTGGCCCAGTACCACACTCCATTCAAGGGATCAGCACATGCCGTCACAAATGGGGCAAGAGTCAAGCAATGCCACTCCAATTCCTCACTGCCCCAGTGACTACTCAGCAGCCCACTCCCACCAGAAAGCAGGCGAATCCTTTCGGAAACATTACCAAGGCCCAGGGGAGGCAGCTGTCTGCCGTTTCCCAGTCCTTAGACTGCAGGGACCCAACTTGGAATTCCATCTCTAGGGGAGATCACTAGCAGACATGTGTCAGAGGGGAACCTGGGGAAGCCAGGGTTCTCCAAAGGGGCAC...
GTCTCCCAGTAGTCTCGACCCAGTGGCCCAGTACCACACTCCATTCAAGGGATCAGCACATGCCGTCACAAATGGGGCAAGAGTCAAGCAATGCCACTCCAATTCCTCACTGCCCCAGTGACTACTCAGCAGCCCACTCCCACCAGAAAGCAGGCGAATCCTTTCGGAAACATTACCAAGGCCCAGGGGAGGCAGCTGTCTGCCGTTTCCCAGTCCTTAGACTGCAGGGACCCAACTTGGAATTCCATCTCTAGGGGAGATCACTAGCAGACATGTGTCAGAGGGGAACCTGGGGAAGCCAGGGTTCTCCAAAGGGGCAC...
benign
260,516
The genetic variant at chromosome 17, position 1650815, affecting gene PRPF8 (pre-mRNA processing factor 8): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic
GGGCTGGGTCCTTGCCCTCATACGGCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGG...
GGGCTGGGTCCTTGCCCTCATACGGCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGG...
pathogenic
260,524
The mutation in gene PRPF8 (pre-mRNA processing factor 8) at chromosome 17, position 1650818—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic
CTGGGTCCTTGCCCTCATACGGCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGGCCC...
CTGGGTCCTTGCCCTCATACGGCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGGCCC...
pathogenic
260,525
Assess the variant on chromosome 17, position 1650839, impacting PRPF8 (pre-mRNA processing factor 8): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Retinitis_pigmentosa', 'Retinitis_pigmentosa_13']
GCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGGCCCCCCGGAGCCCCGCCCAGCGCC...
GCACTCACCGGGTCCTCAGGGTTCCCTGGGGCGCCTGCGCCGGCGGTCGCCCATTCGGGCTCCTGTCCGTGCTGGTGCCCGGGCCGCCCGGCCTGCCCCCGCGCTCGCTCTTTAGCCTGCGGAGTCGCGGCTTCGCCAGGCTGCTGGCGCTCCCTCTCGCGGTCCTGCGCGGCGCGCAGCTGGGTCTGCATGGCCGCCAGCTTGTGCCGCAGCTCAGCGTTCACCAGCAGGAGGCGCTGCAGCTGCTCCTGCAACTGGGAGCGGAGCAAAGGGTGGGGTGGGCGGGGCACCGAGGGCCCCCCGGAGCCCCGCCCAGCGCC...
pathogenic
260,527
Determine whether the variant at chromosome 17, position 1677176, in gene PRPF8 (pre-mRNA processing factor 8) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
CATGCTACTGCGCCTGAGACGCACCTTATAGTTGATGACGACGTTGTTCTTGGCTGTCATGTAGTCGGCTATGTTGTGGTCCACGATGAGGCGCAGCAGCCTGTTGAGCAGAGTCAAGTCGATCTTCTCATACATCTTCTCAAAGCGGGATTCCAGCATGACATTGCACTCGCCTTCACTCGTCTCCCACACGTCCTGCAGGTTATTGATGCCTGAGGAGTAGCAAGGCAGGTCTCCAGCAGGTTAGAAATCCTCTTGCAAGACTAGCCCCACAGGAACTATCATTACCTTCCATAACCAATCCCACTATGATTCCACGT...
CATGCTACTGCGCCTGAGACGCACCTTATAGTTGATGACGACGTTGTTCTTGGCTGTCATGTAGTCGGCTATGTTGTGGTCCACGATGAGGCGCAGCAGCCTGTTGAGCAGAGTCAAGTCGATCTTCTCATACATCTTCTCAAAGCGGGATTCCAGCATGACATTGCACTCGCCTTCACTCGTCTCCCACACGTCCTGCAGGTTATTGATGCCTGAGGAGTAGCAAGGCAGGTCTCCAGCAGGTTAGAAATCCTCTTGCAAGACTAGCCCCACAGGAACTATCATTACCTTCCATAACCAATCCCACTATGATTCCACGT...
benign
260,592
Gene SERPINF1 (serpin family F member 1) variant at chromosome position 1766981 on chromosome 17: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Osteogenesis_imperfecta_type_6']
TCCTGGATTCAAGTGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGATGGTCTCAAACTCCTGACCTCAGGTGATCTACCCGCCTCGGCCTCTCAAAGTGCTGGGATTACAGGTTTGAGCCACTGCGCCTGGCCTTTTTTTTTTTTTTTGAGATGGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCCAAGTTCAAGTGATTCTC...
TCCTGGATTCAAGTGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGATGGTCTCAAACTCCTGACCTCAGGTGATCTACCCGCCTCGGCCTCTCAAAGTGCTGGGATTACAGGTTTGAGCCACTGCGCCTGGCCTTTTTTTTTTTTTTTGAGATGGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCCAAGTTCAAGTGATTCTC...
pathogenic
260,688
Variant chromosome 17, position 1770026, gene SERPINF1: benign or pathogenic? Disease(s)?
pathogenic; ['Osteogenesis_imperfecta']
TGATCCCTTGAATCCAGGAGTTTGAGACCAGCATAGGCAACATAGTGAGACCCCTGTCTCTACAAAAAAGCAAAAATTACCAGGCGTGGTGGCAAGTGCTTGTGGTACTACCTACTTGGGAAGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGATTAAGACTGCAGTGAGGGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGTGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTG...
TGATCCCTTGAATCCAGGAGTTTGAGACCAGCATAGGCAACATAGTGAGACCCCTGTCTCTACAAAAAAGCAAAAATTACCAGGCGTGGTGGCAAGTGCTTGTGGTACTACCTACTTGGGAAGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGATTAAGACTGCAGTGAGGGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGTGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTG...
pathogenic
260,695
Considering the genetic mutation at chromosome 17, position 1775066, impacting SERPINF1 (serpin family F member 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Osteogenesis_imperfecta_type_6']
GGCTTGGAAAGGGAGGTGTCAAAGACCTTGCCCAGCATGGAGTCTGGGTCACAGCTGGGGGAGGATCTGGGAACTGTGCTTGCCTGAAGCTTACCTGCTTGTCATCAAATCCAAGGCAAGGCGTGAATGTCTATAGAGTGAGAGACTTGTGGAGACAGAAGAGCAGAGAGGGAGGAAGAATGAACACTGGGTCTGTTTGGGGCTTTCCCAGCTTTTGAGTCAGACAAGATTTATTTATTTATTTAAGATGGAGTCTCATTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTACAGCCTCCCCACCTCC...
GGCTTGGAAAGGGAGGTGTCAAAGACCTTGCCCAGCATGGAGTCTGGGTCACAGCTGGGGGAGGATCTGGGAACTGTGCTTGCCTGAAGCTTACCTGCTTGTCATCAAATCCAAGGCAAGGCGTGAATGTCTATAGAGTGAGAGACTTGTGGAGACAGAAGAGCAGAGAGGGAGGAAGAATGAACACTGGGTCTGTTTGGGGCTTTCCCAGCTTTTGAGTCAGACAAGATTTATTTATTTATTTAAGATGGAGTCTCATTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTACAGCCTCCCCACCTCC...
pathogenic
260,714
Evaluate if the mutation on chromosome 17 at position 1777333 in SERPINF1 (serpin family F member 1) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Osteogenesis_imperfecta_type_6']
TTGAGATCCGACAGCTGTCTACATGTCGCCTGCTGTGTGACTTTGAGCAGGTTAATAACATGTCTGAGCTTTCCTCCTCTTAAGATGGGGCAGGGGATCGTTACCAACACTTACCCTCCCAGGGTTTGTTGTAAGGACGAATAAGGTAATAGGAAATGGGCCCTCAGACTGGGCACCCACATGTTTGTTCTCTTGAGACTCCTATTTCTAGAATTTAAAGCCAAACTTTGAAAAATAATGACAAACTCCAAATCGTTGGCATCTTTTTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGGCCAGGCTGGAGTGCAGTGGCA...
TTGAGATCCGACAGCTGTCTACATGTCGCCTGCTGTGTGACTTTGAGCAGGTTAATAACATGTCTGAGCTTTCCTCCTCTTAAGATGGGGCAGGGGATCGTTACCAACACTTACCCTCCCAGGGTTTGTTGTAAGGACGAATAAGGTAATAGGAAATGGGCCCTCAGACTGGGCACCCACATGTTTGTTCTCTTGAGACTCCTATTTCTAGAATTTAAAGCCAAACTTTGAAAAATAATGACAAACTCCAAATCGTTGGCATCTTTTTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGGCCAGGCTGGAGTGCAGTGGCA...
pathogenic
260,726
Determine whether the variant at chromosome 17, position 2666046, in gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
TCTTGAACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCA...
TCTTGAACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCA...
pathogenic
260,767
Variant at chromosome position 2666052, chromosome 17, gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Intellectual_disability', 'Lissencephaly_due_to_LIS1_mutation', 'likely other unspecified diseases']
ACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCACCACAG...
ACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCACCACAG...
pathogenic
260,768
Regarding the variant at chromosome 17 and position 2666052, affecting gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
ACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCACCACAG...
ACTTCTGACCTTGTGATTTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACTGCGCTGGCCTAACCCTGTAATTATTATACGTTGATTTTTGGCATGCTCATAATTACCTGGAACATAAAGTTTTTGCTGGTAATTCCCTGTTATCTTTCTTTGCTGATTTGTTTTAAACATACCATTGAATTAAAGCCAGTAATCCCACCAGTTATACAATACTACTGGAGTGTGTTTTGTTTTGTATTTTGAGACGTAGTTTCGCTGTTGTTGCCTAGGCTGGAGTGCAGTGGCACGAACTGGGCTCACCACAG...
pathogenic
260,769
Regarding the variant found on chromosome 17 at position 2667142 in gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
CATTTGAAACTTATAAATATGAAGTTTCTCTTCTGATGTTAAAAAAAAGAAAGAAAAACTTATAACTAAGAATATAATATTATGGATGTAGTATGACAGGGGCTAAAAGTTCTGGAGGCTTTGCGGGGGTGTCCTTTTTAATGAAATACTTGTATGATTTGAAAGGGAATACTCTTGAAAAGAGTATCTTCAGGGTTAATGAGATTTTAAATAAATTCTATTTCTTCAGAATAGAAATGAGGTCTTTTTTTTAGGAGTCATTTGAATTTTTCTTTCAGAAATCGAGCTATAGCAGATTATCTTCGTTCAAATGGCTATGA...
CATTTGAAACTTATAAATATGAAGTTTCTCTTCTGATGTTAAAAAAAAGAAAGAAAAACTTATAACTAAGAATATAATATTATGGATGTAGTATGACAGGGGCTAAAAGTTCTGGAGGCTTTGCGGGGGTGTCCTTTTTAATGAAATACTTGTATGATTTGAAAGGGAATACTCTTGAAAAGAGTATCTTCAGGGTTAATGAGATTTTAAATAAATTCTATTTCTTCAGAATAGAAATGAGGTCTTTTTTTTAGGAGTCATTTGAATTTTTCTTTCAGAAATCGAGCTATAGCAGATTATCTTCGTTCAAATGGCTATGA...
pathogenic
260,775
Is the genetic variant on chromosome 17, position 2670201, gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
CATCTCTACTAAAATACAAAAAAATTAGCTGGGCATGGCAGCGTGCGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGCAGGAAATTCGCTTGAACCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGA...
CATCTCTACTAAAATACAAAAAAATTAGCTGGGCATGGCAGCGTGCGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGCAGGAAATTCGCTTGAACCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGA...
pathogenic
260,778
Assess the variant on chromosome 17, position 2670215, impacting PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
TACAAAAAAATTAGCTGGGCATGGCAGCGTGCGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGCAGGAAATTCGCTTGAACCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGAGCTCAGGAGTTAGA...
TACAAAAAAATTAGCTGGGCATGGCAGCGTGCGCCTGTAGTCCCAGCTACTTGGAAGGCTGAGGCAGGAAATTCGCTTGAACCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGAGCTCAGGAGTTAGA...
pathogenic
260,779
Assess the variant on chromosome 17, position 2670296, impacting PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
CCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGAGCTCAGGAGTTAGAGAGCAGCCTGGGCAACATAGCAAGACCTCGTCTCTACTTAAAATTAGCCAGGTATGGTGGTGCATGCCTGTAGTCCTAGCT...
CCCAGGAGACAGGTTGCAGTTAGCCAAGATCGCTCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAGGTAGTTACAACTAACCAAATAGTAACGACGGTTTGGCCTTACTACTAACAGCAGAAGAAATAAACACTGAAATTATGGGCCGGGTGTGGTAGCTCATGCCTATAGTCCTAGGACTTTGGGAGGCCAAGGTGGGAGGACTGCTTGAGCTCAGGAGTTAGAGAGCAGCCTGGGCAACATAGCAAGACCTCGTCTCTACTTAAAATTAGCCAGGTATGGTGGTGCATGCCTGTAGTCCTAGCT...
pathogenic
260,782
Chromosome 17, position 2672730, gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
CGAGCCCAGATTCTCTTGCTCACTTAAGTGAAATGAGCTGAGCGCACAGACCCCATGCCCTCGTTCATTATTTCCCGGGTCTTGTTGTGGGAACTGTTTTCTGAGGCAGTATGTTTTGTGGAAAGAGAGTAATTTGCTTTGGAGTCAGACACCTGGGTTCAAATTCCTACTTGTCTACTTACGGTATTAGAAAATTTAAACCTCTTTCATCTGCAAAACAGAGGTAATAATACCAGAGTCATAGAGTTGTCATGAGGATAAGATGAAGTCATAAGATAAATCATCTTGGTGTAGTACCTGCCACATAGGAGATGCTCATT...
CGAGCCCAGATTCTCTTGCTCACTTAAGTGAAATGAGCTGAGCGCACAGACCCCATGCCCTCGTTCATTATTTCCCGGGTCTTGTTGTGGGAACTGTTTTCTGAGGCAGTATGTTTTGTGGAAAGAGAGTAATTTGCTTTGGAGTCAGACACCTGGGTTCAAATTCCTACTTGTCTACTTACGGTATTAGAAAATTTAAACCTCTTTCATCTGCAAAACAGAGGTAATAATACCAGAGTCATAGAGTTGTCATGAGGATAAGATGAAGTCATAAGATAAATCATCTTGGTGTAGTACCTGCCACATAGGAGATGCTCATT...
pathogenic
260,787
Chromosome 17, position 2674087, gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Inborn_genetic_diseases', 'Lissencephaly_due_to_LIS1_mutation']
AGGAAGGATTGCTTGAGGACAGGAGTTCGAGACCAGTGTGAGCAAAATATGGAGACCTTGTCTCTACAAAAAATAAAATAGTTGTGGGTGTGGTGGTACCAGATGTGGTGGTACACACCTGTGTAGTTCCAGCTACCCGACAGGCTGAGGCGGGAAGAGCTCTTGAGCCCAGGAGTTCAAGGCTACAGTGAGCTATGATTGCACCACTGCACTTTAGCCTGGGTAACAGAGCAAGTCCTTGCCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAATGTTTCCCTAGCGTTCATATGTAAACATTCAGACTCACTGAGGTAA...
AGGAAGGATTGCTTGAGGACAGGAGTTCGAGACCAGTGTGAGCAAAATATGGAGACCTTGTCTCTACAAAAAATAAAATAGTTGTGGGTGTGGTGGTACCAGATGTGGTGGTACACACCTGTGTAGTTCCAGCTACCCGACAGGCTGAGGCGGGAAGAGCTCTTGAGCCCAGGAGTTCAAGGCTACAGTGAGCTATGATTGCACCACTGCACTTTAGCCTGGGTAACAGAGCAAGTCCTTGCCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAATGTTTCCCTAGCGTTCATATGTAAACATTCAGACTCACTGAGGTAA...
pathogenic
260,794
Determine if the mutation at chromosome 17, position 2674158 in gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
AATAAAATAGTTGTGGGTGTGGTGGTACCAGATGTGGTGGTACACACCTGTGTAGTTCCAGCTACCCGACAGGCTGAGGCGGGAAGAGCTCTTGAGCCCAGGAGTTCAAGGCTACAGTGAGCTATGATTGCACCACTGCACTTTAGCCTGGGTAACAGAGCAAGTCCTTGCCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAATGTTTCCCTAGCGTTCATATGTAAACATTCAGACTCACTGAGGTAAGTATATGAATATATTCAAATGTTGATAATCGTGATGCCTTTTGTTTTTAAACCATTTGTACAGGTTGAAAT...
AATAAAATAGTTGTGGGTGTGGTGGTACCAGATGTGGTGGTACACACCTGTGTAGTTCCAGCTACCCGACAGGCTGAGGCGGGAAGAGCTCTTGAGCCCAGGAGTTCAAGGCTACAGTGAGCTATGATTGCACCACTGCACTTTAGCCTGGGTAACAGAGCAAGTCCTTGCCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAATGTTTCCCTAGCGTTCATATGTAAACATTCAGACTCACTGAGGTAAGTATATGAATATATTCAAATGTTGATAATCGTGATGCCTTTTGTTTTTAAACCATTTGTACAGGTTGAAAT...
pathogenic
260,795
Mutation found at chromosome 17 position 2680178, gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCC...
GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCC...
pathogenic
260,806
Is the genetic mutation found on chromosome 17 at position 2680205, within the gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
TTTGGGAGGCCGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCTTGAG...
TTTGGGAGGCCGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCTTGAG...
pathogenic
260,807
Is the genetic change at chromosome 17, position 2680242, within gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Lissencephaly_due_to_LIS1_mutation']
GAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCTTGAGAATCGTTTGCACCTGGGAGACGGAGGTTGCAGTGAGC...
GAGTTCGAGACCAGCCTGACCAACATGGAGGAACCCCATCGCTGCTAAAAACACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAAGGCTGAGGCAGGCAAATCACTTTAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCATTGTACTCCAGCCTGGGCAACAAGAGTGAAACCATCTCAAAAAAAAAAAAAAAAAAACCCGGGCATGGTGGCGCACGTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCTTGAGAATCGTTTGCACCTGGGAGACGGAGGTTGCAGTGAGC...
pathogenic
260,810
Is chromosome 17, position 3476190, gene ASPA variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Canavan_Disease,_Familial_Form', 'Spongy_degeneration_of_central_nervous_system']
CACAGAAGACAAACTCTGTACACAAAAAACAAGGTAAGTATGGGAAATAATTGCTGCAATTCATTAACTCTCAAAAAAGTTATTCATTTTGACATGTAAGAGAAACTTTATTTATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTT...
CACAGAAGACAAACTCTGTACACAAAAAACAAGGTAAGTATGGGAAATAATTGCTGCAATTCATTAACTCTCAAAAAAGTTATTCATTTTGACATGTAAGAGAAACTTTATTTATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTT...
pathogenic
260,835
Gene ASPA variant at chromosome position 3476197 on chromosome 17: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
GACAAACTCTGTACACAAAAAACAAGGTAAGTATGGGAAATAATTGCTGCAATTCATTAACTCTCAAAAAAGTTATTCATTTTGACATGTAAGAGAAACTTTATTTATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTTAAAACCA...
GACAAACTCTGTACACAAAAAACAAGGTAAGTATGGGAAATAATTGCTGCAATTCATTAACTCTCAAAAAAGTTATTCATTTTGACATGTAAGAGAAACTTTATTTATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTTAAAACCA...
pathogenic
260,836
Assess the variant on chromosome 17, position 3476302, impacting ASPA: is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
TATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTTAAAACCAAAGCAACTAAACAACTGTCATCTGTTTACTTTTACGTGTGTTTTCATCATCTCTACACCGTCTGAAGTGTTCAGTGTACATGGATGTGGACAGACAGTCAAAGCC...
TATGAATGTGAAATGTGCTTCAAAGTGCTGATCTGTTAAAATTCCATAAAACAAGCTTCAAAATGCAAGTCATTTGTGCCAGCTACGAGTAAATAACTGAAGCAGCATTTCCAGAGAGACTAGGGCAAAGGACAGAACAAACTACAAATCAGCAGAAAAGAAACCAAGCATAGTAGAGTGTTAATAATTCACCATGGTTACTGCTCTTAAAACCAAAGCAACTAAACAACTGTCATCTGTTTACTTTTACGTGTGTTTTCATCATCTCTACACCGTCTGAAGTGTTCAGTGTACATGGATGTGGACAGACAGTCAAAGCC...
pathogenic
260,843
Is the genetic change at chromosome 17, position 3481603, within gene ASPA benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Canavan_Disease,_Familial_Form', 'Inborn_genetic_diseases', 'Spongy_degeneration_of_central_nervous_system']
ACCTTCCCACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAA...
ACCTTCCCACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAA...
pathogenic
260,850
Variant in gene ASPA, located at chromosome 17 position 3481609: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Spongy_degeneration_of_central_nervous_system']
CCACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAA...
CCACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAA...
pathogenic
260,851
A genetic variant on chromosome 17, position 3481610, affects the gene ASPA. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
CACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAA...
CACAGCACTGTCTCAACATGGCCCCTTCCACCTTCCCACTGCACCATCTCAACGTGGCCCTTTCCACCTTCCCCCTGCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAA...
pathogenic
260,852
Chromosome 17, position 3481686, gene ASPA: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Canavan_Disease,_Familial_Form', 'Spongy_degeneration_of_central_nervous_system']
GCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATT...
GCACCGACTCGACGTGGTCCCTTCTACCTTCCCAGTGCACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATT...
pathogenic
260,856
Chromosome 17, position 3481723, gene ASPA: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Inborn_genetic_diseases', 'Spongy_degeneration_of_central_nervous_system']
CACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATTTGAGAATGGAAGAAAAACTACTGGCCCTTGTGCCAGA...
CACTATCTCAAGATGCCGGCTTTGTCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATTTGAGAATGGAAGAAAAACTACTGGCCCTTGTGCCAGA...
pathogenic
260,858
Evaluate the clinical significance of the mutation at chromosome 17, position 3481747 in gene ASPA: benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
TCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATTTGAGAATGGAAGAAAAACTACTGGCCCTTGTGCCAGAAAAAAAATACATATATCTGTACCT...
TCCTCATGGTTTTTGCTTCAAAGTCACAAAATAACTACTCCACCTTCCTGATCTCATTCCAGGCAGGAATTAGCCCATTGTACACAGTAGGTCCCTTGAAGATACTAGCAAAAATAACCAAGGAATACAAATAGATGGAATTTTAGGAAAATGTGGTTGAACGGTTTAATGAGGAAAAGTAAATGAAAAACATTATTATATCTAGAAAAAAAATGTATCTTAACCATTGTGGGAAGTGGGGAGAGGGTAGAGGCCCATTTGAGAATGGAAGAAAAACTACTGGCCCTTGTGCCAGAAAAAAAATACATATATCTGTACCT...
pathogenic
260,860
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 17, position 3483501, gene ASPA. What disease(s) is it linked to if pathogenic?
pathogenic; ['Abnormality_of_metabolism/homeostasis', 'Spongy_degeneration_of_central_nervous_system']
TATAAACATTTCAGGTAAGTTTTTACTTACCACACAGATTTTTCATATTAAAGATTTGGCGACTGGTTCTTTTTACACTGTGTTCTTATTATATGTTTATATTATCTCAGGCACAGATGTTGTTCATCTTTTTCTTTCTGCTTATAACAGCAAAAAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTTGGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCTAACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTT...
TATAAACATTTCAGGTAAGTTTTTACTTACCACACAGATTTTTCATATTAAAGATTTGGCGACTGGTTCTTTTTACACTGTGTTCTTATTATATGTTTATATTATCTCAGGCACAGATGTTGTTCATCTTTTTCTTTCTGCTTATAACAGCAAAAAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTTGGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCTAACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTT...
pathogenic
260,864
Variant at chromosome position 3483521, chromosome 17, gene ASPA: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
TTTTACTTACCACACAGATTTTTCATATTAAAGATTTGGCGACTGGTTCTTTTTACACTGTGTTCTTATTATATGTTTATATTATCTCAGGCACAGATGTTGTTCATCTTTTTCTTTCTGCTTATAACAGCAAAAAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTTGGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCTAACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTTTAATTCAGATGTTTCATTAC...
TTTTACTTACCACACAGATTTTTCATATTAAAGATTTGGCGACTGGTTCTTTTTACACTGTGTTCTTATTATATGTTTATATTATCTCAGGCACAGATGTTGTTCATCTTTTTCTTTCTGCTTATAACAGCAAAAAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTTGGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCTAACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTTTAATTCAGATGTTTCATTAC...
pathogenic
260,866
A genetic variant on chromosome 17, position 3489315, affects the gene ASPA. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
AGAAAGATTGTCTCTCTAATGTTAAACATGCTTTTTTCCCAGTGAGTGCATGATATAAAATATTCCAAATAAAACAGCAAAGTTGGAAGGAGAACATATAACATTTCTAATTATTTACAATGAGCTTAATACTCCCTCATATTGAAATATTTTAAAGATTTGGCTCAACTTGTAAGGGCCAAACATATCAGCAATGTTTGTTCTGGCTAAGAGTAGCATTGCCTACAAATATCATAGCCTAAGATTGATATTTGAGAGTTTGGAAATCTTAAGCTTTTATTTGGTGTCACAGAGAAACAGGATCTGTATCTCTTATTGCT...
AGAAAGATTGTCTCTCTAATGTTAAACATGCTTTTTTCCCAGTGAGTGCATGATATAAAATATTCCAAATAAAACAGCAAAGTTGGAAGGAGAACATATAACATTTCTAATTATTTACAATGAGCTTAATACTCCCTCATATTGAAATATTTTAAAGATTTGGCTCAACTTGTAAGGGCCAAACATATCAGCAATGTTTGTTCTGGCTAAGAGTAGCATTGCCTACAAATATCATAGCCTAAGATTGATATTTGAGAGTTTGGAAATCTTAAGCTTTTATTTGGTGTCACAGAGAAACAGGATCTGTATCTCTTATTGCT...
pathogenic
260,881
Is the genetic change at chromosome 17, position 3498971, within gene ASPA benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
GGGCATGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGAGCCTGAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGA...
GGGCATGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGAGCCTGAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGA...
pathogenic
260,896
Gene mutation in ASPA at chromosome 17, position 3498975—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
ATGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGAGCCTGAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAG...
ATGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGAGCCTGAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAG...
pathogenic
260,897
Variant in ASPA, chromosome 17, position 3499015—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Canavan_Disease,_Familial_Form', 'Spongy_degeneration_of_central_nervous_system']
GAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAGGTTCCTTTAGTGATTCTGGGGCAAGTCTCTGCCTGAAAAA...
GAGGCAGGAAAATTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAGGTTCCTTTAGTGATTCTGGGGCAAGTCTCTGCCTGAAAAA...
pathogenic
260,908
Mutation at chromosome 17, position 3499027, within ASPA: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Spongy_degeneration_of_central_nervous_system']
TTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAGGTTCCTTTAGTGATTCTGGGGCAAGTCTCTGCCTGAAAAACCACCGGTTCAG...
TTGCTTGAACTCGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGACAGAGCTGAGATTACGTCTAAAAAGAAAAAGAAAAAATGCTGATTTCTGAGTCCTCTTCCCAGGGGCTCTGATCTAATTCATCAGGGTGTAGACAGGGAATCAATTGAGTTCACCAGGTGATTTTCATGTGGCTCAGGTCTGGATAGCACTGCACAATGTCGGAATCTCCACAGGTGGGGCTAGCCAGACGTGTGTTGAAGAGGTTCCTTTAGTGATTCTGGGGCAAGTCTCTGCCTGAAAAACCACCGGTTCAG...
pathogenic
260,909
Classify the chromosome 17 variant at position 3513849 affecting gene SPATA22 as benign or pathogenic. If pathogenic, which disease(s) is associated?
benign
ACGGCTTTATCCATAACAGATACGGCTTTATCCATTAATGGATATGACTTTCTCCATTAATATCTGAGTCAAAGCAATTCTGGAATTCCCAGCTCCATAGTGTGGAGCTTGGCATCATGAATCCAAACCACTTCCTTTCAGACCAAGATGTCTGTTCAGGCTTAATGCGGGTAGCTAACTCCAGATGTGGAATGCTGATTTGTACAATCTCCAGGCTAAAAGGGACCTTAAACTTCTTCCAATGACCATTTTCAACAACATTCCTCATTAAGTGCGCAACCAGCTTCTGCTTAAACATCTCCAACATCTGGAGCAGTTGC...
ACGGCTTTATCCATAACAGATACGGCTTTATCCATTAATGGATATGACTTTCTCCATTAATATCTGAGTCAAAGCAATTCTGGAATTCCCAGCTCCATAGTGTGGAGCTTGGCATCATGAATCCAAACCACTTCCTTTCAGACCAAGATGTCTGTTCAGGCTTAATGCGGGTAGCTAACTCCAGATGTGGAATGCTGATTTGTACAATCTCCAGGCTAAAAGGGACCTTAAACTTCTTCCAATGACCATTTTCAACAACATTCCTCATTAAGTGCGCAACCAGCTTCTGCTTAAACATCTCCAACATCTGGAGCAGTTGC...
benign
260,935
Is the genetic change at chromosome 17, position 3640221, within gene CTNS (cystinosin, lysosomal cystine transporter) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['CTNS-related_disorder', 'Cystinosis', 'Inborn_genetic_diseases', 'Infantile_nephropathic_cystinosis', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
ATTTCTATCTTGTAGCTTTCACAAGCCACTAGTTGTATGTAATTATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGC...
ATTTCTATCTTGTAGCTTTCACAAGCCACTAGTTGTATGTAATTATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGC...
pathogenic
261,031
Variant at chromosome 17, position 3640242, gene CTNS (cystinosin, lysosomal cystine transporter): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAAGCCACTAGTTGTATGTAATTATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGCCTCCCAAAGTGCTGGAATTAC...
CAAGCCACTAGTTGTATGTAATTATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGCCTCCCAAAGTGCTGGAATTAC...
pathogenic
261,032
Determine whether the variant at chromosome 17, position 3640264, in gene CTNS (cystinosin, lysosomal cystine transporter) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
TATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGCCTCCCAAAGTGCTGGAATTACACACACGAGCCACTGCGCTCAG...
TATCAATCTGGTTTTTTTTTTGTTTTTTTTTTTTAATTTGAGACGGAGTTTCACTCTTATCACTCAGGCTGGAGTGCAATGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGATTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTTCAAGTGATCCAACTGCCTCGGCCTCCCAAAGTGCTGGAATTACACACACGAGCCACTGCGCTCAG...
pathogenic
261,033
Is the genetic mutation found on chromosome 17 at position 3648903, within the gene CTNS (cystinosin, lysosomal cystine transporter), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
ACAACTATTCACCCTTCCTCCTCCAGTACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAA...
ACAACTATTCACCCTTCCTCCTCCAGTACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAA...
pathogenic
261,047
Evaluate the clinical significance of the mutation at chromosome 17, position 3648911 in gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['CTNS-related_disorder', 'Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
TCACCCTTCCTCCTCCAGTACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCG...
TCACCCTTCCTCCTCCAGTACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCG...
pathogenic
261,048
A genetic variant at chromosome 17, position 3648929, affecting gene CTNS (cystinosin, lysosomal cystine transporter)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
TACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCGCAGACTCTCAGAGCCTGT...
TACCCCGCAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCGCAGACTCTCAGAGCCTGT...
pathogenic
261,049
Clinically, how would you classify the variant at chromosome 17, position 3648936, gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCGCAGACTCTCAGAGCCTGTCATCGCA...
CAGATAGTCAGCCCCAGGAAGGGGACCAGTGCCAGGGTGAGCTGGGTTGGGAAGGGACCCCAAAGGGCTCCTTAGAAACTCATTAGCTGGGCCCATGTGTCTCTCTGAGAGTGCAGGAAAGGGGCTGGCCCAGTTCTTCAGGACCATTTTGACTTCATGAACAGAGGAGACCCCTGTGCTTTCATCTGAAGAGGTGGTTCACGGCTGCCTTTTACGCTCCCAGGTCACGCTGGAATTCCCCTGTAATGATTTTTGGGCTCCATGGTTCTCTAACAATCTCTGGTTAACTCAGCCGCAGACTCTCAGAGCCTGTCATCGCA...
pathogenic
261,052
Regarding the variant found on chromosome 17 at position 3654996 in gene CTNS: is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAGTGCTTCAAGGGTCCTCATTAAGAAGCCACTGAAGGATGTGGTAGAGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAG...
CAGTGCTTCAAGGGTCCTCATTAAGAAGCCACTGAAGGATGTGGTAGAGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAG...
pathogenic
261,056
Variant in gene CTNS, located at chromosome 17 position 3655020: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Nephropathic_cystinosis']
GAAGCCACTGAAGGATGTGGTAGAGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGT...
GAAGCCACTGAAGGATGTGGTAGAGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGT...
pathogenic
261,057
A genetic alteration at chromosome 17, position 3655063, in gene CTNS—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAA...
CTCAGGAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAA...
pathogenic
261,059
A genetic variant at chromosome 17, position 3655083, affecting gene CTNS—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGGGGCGGAGATTGCA...
GGATCGCTTGAGCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGGGGCGGAGATTGCA...
pathogenic
261,061
Does the variant impacting CTNS on chromosome 17, position 3655094, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGGGGCGGAGATTGCAGTGAGCCAAGA...
GCCCAGGAGTTGGAGTGATCAGTGAGCTATAGTTGCACCACTGCACTACAGCCTGAGCTACAGAGCAAGACCTGCCTCTCGGAAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCACCACTTTGGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGAAGATCGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTACGAAAAATACAAAAAATTAGCTGGGTATGGTTGTGGGCACCTGTAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGGGGCGGAGATTGCAGTGAGCCAAGA...
pathogenic
261,062
Gene CTNS variant at chromosome 17, position 3656542—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Nephropathic_cystinosis']
TGAAAGTCCATCTCTACTAAAAATTCAAAAATTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATG...
TGAAAGTCCATCTCTACTAAAAATTCAAAAATTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATG...
pathogenic
261,086
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 17, position 3656572, gene CTNS. What disease(s) is it linked to if pathogenic?
pathogenic; ['CTNS-related_disorder', 'Cystinosis', 'Inborn_genetic_diseases', 'Infantile_nephropathic_cystinosis', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
ATTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGG...
ATTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGG...
pathogenic
261,089
Does the variant impacting CTNS on chromosome 17, position 3656585, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTC...
GGTGGCGCACACCTGTAATCCCAGGTACTCGGGACTCAGGAGCCTAAGGCAGGAGAACCGCTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACTCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTC...
pathogenic
261,090
Variant at chromosome position 3656705, chromosome 17, gene CTNS: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Nephropathic_cystinosis']
GGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATT...
GGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATT...
pathogenic
261,096
Clinical impact (benign or pathogenic) of the variant at chromosome 17, location 3656724, gene CTNS: what disease(s) if pathogenic?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAAC...
GTCTCAAAAAAAAAAAAAAAAAGGAAAGTCTCACTCAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAAC...
pathogenic
261,097
Does the variant impacting CTNS on chromosome 17, position 3656759, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAACAGGTTGTGGTGCCTCCTGGAGTGACAAACTCCTCT...
CAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAACAGGTTGTGGTGCCTCCTGGAGTGACAAACTCCTCT...
pathogenic
261,100
Is the genetic mutation found on chromosome 17 at position 3656759, within the gene CTNS, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAACAGGTTGTGGTGCCTCCTGGAGTGACAAACTCCTCT...
CAGGCCAGGCGCGGTGGCTCACATCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTAGATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAGCATGGCGAACAGGAGGTTCAAGTTGGCTGGTGGGCGCAGCGTCTCTCCTTTTGCTTAGTAAGCTCTTGGAAGGTGAGGCTGCGGGTGGTGCGTCCCTCCGTTCCCTAGCGTGTTGCATAGAGCTAGATGCCAGCGGGGTCCTCGGTAACTGTACGTGGCATCGGATTGAACCTCAGTCTTCCTAACAGGTTGTGGTGCCTCCTGGAGTGACAAACTCCTCT...
pathogenic
261,101
For chromosome 17, position 3658015, gene CTNS: benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GGACAGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCAC...
GGACAGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCAC...
pathogenic
261,110
Variant on chromosome 17, at position 3658018, affecting CTNS (cystinosin, lysosomal cystine transporter): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['CTNS-related_disorder', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CAGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCC...
CAGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCC...
pathogenic
261,111
Does the genetic variant at chromosome 17, position 3658019, impacting gene CTNS (cystinosin, lysosomal cystine transporter), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
AGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCT...
AGTACCCTGCTTGAGAAGGGCCGAGTCCTCCTTCCCCGTGGCCTGGGAGCCCTGTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCT...
pathogenic
261,112
Is the genetic variant on chromosome 17, position 3658072, gene CTNS (cystinosin, lysosomal cystine transporter), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCC...
GTCCCTCCCATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCC...
pathogenic
261,115
Does the genetic variant at chromosome 17, position 3658081, impacting gene CTNS (cystinosin, lysosomal cystine transporter), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
ATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCC...
ATTCCCCACAGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCC...
pathogenic
261,116
Clinical classification of chromosome 17, position 3658090, gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
AGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTC...
AGTGGTGCCAGTCCTCACCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTC...
pathogenic
261,117
For chromosome 17, position 3658129, gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Nephropathic_cystinosis', 'Nephrotic_syndrome']
CCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCAC...
CCACCCCCGCCAGCCCTCACCCCCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCAC...
pathogenic
261,119
Benign or pathogenic: chromosome 17, position 3658151, gene CTNS (cystinosin, lysosomal cystine transporter) variant? Disease(s) if pathogenic?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTG...
CCTGCCCTGCCCCTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTG...
pathogenic
261,121
Evaluate the clinical significance of the mutation at chromosome 17, position 3658163 in gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
CTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGTCCCTCC...
CTCCACCCCTCGCCAGTCCTCGCCCCTGGCCCTGCCATGCCCTTCCACCCCCGCCAGCCCTCACCCCCTGCCATGCCCCTCCACCCCCGCCAGTCCTTACCCACTGCCCTGCCCCTCCACCCCCCACCAGTCCTCACCCCCTGGGGTCCTCACCCCTGCCCTGCCCCTCCACCCCTGCCAGTCCTCACCCCCTGCCCTGCCCCACCACCCCTCGCCAGTCCTTACCCCCCACCCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGCCCCTCCACCCCCGCCAGTCCTCACCCTCTGCCCTGTCCCTCC...
pathogenic
261,124
Variant at chromosome position 3659873, chromosome 17, gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
TGTGGTCCACATGTTCCCCTGCCACAACCCCAGTGCAGCCCCCACCTTGCAGGGGCTCCTTCAAGGCCAGGGTCCAGCCTCCGTGCCCCTCTCTAAGCCCGCCCTATCCGGGGCCGTCCTTGCTCAGCCCCGGCGTGGCCTCTGTGTGGGTCCACATCTCTGCCCTCCTCTCGCCCCCAGCGCGGTGGCCAGCGCGTGTCCTGGCCTGCCATCGGCTTCCTGGTGCTCGCGTGGCTCTTCGCATTTGTCACCATGATCGTGGCTGCAGTGGGAGTGACCACGTGGCTGCAGTTTCTCTTCTGCTTCTCCTACATCAAGCT...
TGTGGTCCACATGTTCCCCTGCCACAACCCCAGTGCAGCCCCCACCTTGCAGGGGCTCCTTCAAGGCCAGGGTCCAGCCTCCGTGCCCCTCTCTAAGCCCGCCCTATCCGGGGCCGTCCTTGCTCAGCCCCGGCGTGGCCTCTGTGTGGGTCCACATCTCTGCCCTCCTCTCGCCCCCAGCGCGGTGGCCAGCGCGTGTCCTGGCCTGCCATCGGCTTCCTGGTGCTCGCGTGGCTCTTCGCATTTGTCACCATGATCGTGGCTGCAGTGGGAGTGACCACGTGGCTGCAGTTTCTCTTCTGCTTCTCCTACATCAAGCT...
pathogenic
261,128
A mutation at chromosome position 3659926 on chromosome 17 in gene CTNS (cystinosin, lysosomal cystine transporter): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Cystinosis', 'Inborn_genetic_diseases', 'Juvenile_nephropathic_cystinosis', 'Nephropathic_cystinosis', 'Ocular_cystinosis']
GGCTCCTTCAAGGCCAGGGTCCAGCCTCCGTGCCCCTCTCTAAGCCCGCCCTATCCGGGGCCGTCCTTGCTCAGCCCCGGCGTGGCCTCTGTGTGGGTCCACATCTCTGCCCTCCTCTCGCCCCCAGCGCGGTGGCCAGCGCGTGTCCTGGCCTGCCATCGGCTTCCTGGTGCTCGCGTGGCTCTTCGCATTTGTCACCATGATCGTGGCTGCAGTGGGAGTGACCACGTGGCTGCAGTTTCTCTTCTGCTTCTCCTACATCAAGCTCGCAGTCACGCTGGTCAAGTATTTTCCACAGGTACCTCCAGGGCCCTGTTCAC...
GGCTCCTTCAAGGCCAGGGTCCAGCCTCCGTGCCCCTCTCTAAGCCCGCCCTATCCGGGGCCGTCCTTGCTCAGCCCCGGCGTGGCCTCTGTGTGGGTCCACATCTCTGCCCTCCTCTCGCCCCCAGCGCGGTGGCCAGCGCGTGTCCTGGCCTGCCATCGGCTTCCTGGTGCTCGCGTGGCTCTTCGCATTTGTCACCATGATCGTGGCTGCAGTGGGAGTGACCACGTGGCTGCAGTTTCTCTTCTGCTTCTCCTACATCAAGCTCGCAGTCACGCTGGTCAAGTATTTTCCACAGGTACCTCCAGGGCCCTGTTCAC...
pathogenic
261,131
Is the genetic variant on chromosome 17, position 4898824, gene CHRNE (cholinergic receptor nicotinic epsilon subunit), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
CTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCT...
CTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCT...
pathogenic
261,291
Variant chromosome 17, position 4898827, gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? Disease(s)?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
AGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTG...
AGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTG...
pathogenic
261,292
Gene CHRNE (cholinergic receptor nicotinic epsilon subunit) variant at chromosome position 4898846 on chromosome 17: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
TGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGC...
TGAGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGC...
pathogenic
261,294
Classify the chromosome 17 variant at position 4898848 affecting gene CHRNE (cholinergic receptor nicotinic epsilon subunit) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B']
AGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCA...
AGCGGAATGACAAGGTGGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCA...
pathogenic
261,295
Determine whether the variant at chromosome 17, position 4898864, in gene CHRNE (cholinergic receptor nicotinic epsilon subunit) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Congenital_myasthenic_syndrome', 'Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
GGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCT...
GGGAGGCTCCTTCCCTCTGAAAGCCCTGCTGTCCCGGCTGCCATGACCCTAGGCCCCTGGGCAGAGTTCTGGGGAGAGGATGGTGGTGGTGGCTTCCTGAAAGCGGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCT...
pathogenic
261,296
Evaluate the clinical significance of the mutation at chromosome 17, position 4898968 in gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
GGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGC...
GGGCCCCTCTGGGAGCTCAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGC...
benign
261,298
Clinically, how would you classify the variant at chromosome 17, position 4898985, gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_myasthenic_syndrome_4A']
CAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGAC...
CAGAGGGCAGTCAGCCACTACCACTGCCCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGAC...
pathogenic
261,299
The genetic variant at chromosome 17, position 4899012, affecting gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome', 'Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
CCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTG...
CCTGCGCTCCCTTCAGATTCCGAGGACTTCCCAGCTGGCCCCCAGGGGGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTG...
pathogenic
261,301
Evaluate this variant at chromosome 17, position 4899059, gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Abnormality_of_the_musculature', 'Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4C']
GGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTC...
GGCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTC...
pathogenic
261,306
Clinical significance of chromosome 17, position 4899060, gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Congenital_myasthenic_syndrome_4A']
GCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCC...
GCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCC...
pathogenic
261,307
Gene mutation in CHRNE (cholinergic receptor nicotinic epsilon subunit) at chromosome 17, position 4899060—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Congenital_myasthenic_syndrome_4A']
GCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCC...
GCGAGTGGTGCACCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCC...
pathogenic
261,308
Clinically, how would you classify the variant at chromosome 17, position 4899072, gene CHRNE (cholinergic receptor nicotinic epsilon subunit): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
CCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAG...
CCCTCTCCCCTAACATCCCAGCCTGCCTTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAG...
pathogenic
261,310
Is the chromosome 17, position 4899099 variant in CHRNE (cholinergic receptor nicotinic epsilon subunit) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
TTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCT...
TTTCCTCCGGGTGAGGGGCACTGTGAGTCTCCTCCTGCAGTCTCTGTGTCTCCCTCAACTCTTCTGCCACCCCTTCTTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCT...
pathogenic
261,313
The mutation impacting CHRNE on chromosome 17 at position 4899175: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
TTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTC...
TTCCCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTC...
benign
261,319
Evaluate if the mutation on chromosome 17 at position 4899178 in CHRNE is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
CCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTG...
CCTTCTTTCCCTCTCCCAGTTGAGACACCCCCCCAACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTG...
pathogenic
261,320
Determine if the mutation at chromosome 17, position 4899213 in gene CHRNE is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
ACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCT...
ACCTCAGCCCTTGGTGACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCT...
pathogenic
261,323
Determine if the mutation at chromosome 17, position 4899229 in gene CHRNE is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4C']
ACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCT...
ACTTCTTCTCCTGCCCCACCCAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCT...
pathogenic
261,325
Clinical impact (benign or pathogenic) of the variant at chromosome 17, location 4899252, gene CHRNE: what disease(s) if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
GTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGAC...
GTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGAC...
pathogenic
261,326
Variant at chromosome position 4899255, chromosome 17, gene CHRNE: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
TTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACA...
TTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACA...
pathogenic
261,327
Considering the variant on chromosome 17, location 4899258, involving gene CHRNE, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
TTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCT...
TTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCT...
pathogenic
261,328
Variant in gene CHRNE (cholinergic receptor nicotinic epsilon subunit), located at chromosome 17 position 4899288: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome', 'Congenital_myasthenic_syndrome_4A']
CAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGC...
CAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGC...
pathogenic
261,329
Is the chromosome 17, position 4899305 variant in CHRNE clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
TCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTC...
TCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTC...
pathogenic
261,332
Benign or pathogenic: chromosome 17, position 4899308, gene CHRNE variant? Disease(s) if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome_4A']
GAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCAT...
GAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCAT...
pathogenic
261,333
Benign or pathogenic: chromosome 17, position 4899313, gene CHRNE variant? Disease(s) if pathogenic?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
GTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAG...
GTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAG...
pathogenic
261,334
Mutation at chromosome 17, position 4899323, within CHRNE: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Congenital_myasthenic_syndrome_4A']
CATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGC...
CATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGC...
pathogenic
261,336
Is the genetic change at chromosome 17, position 4899325, within gene CHRNE benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['CHRNE-related_disorder', 'Congenital_myasthenic_syndrome', 'Congenital_myasthenic_syndrome_4A']
TGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTT...
TGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTT...
pathogenic
261,337
Is the genetic change at chromosome 17, position 4899326, within gene CHRNE benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Abnormality_of_the_musculature', 'CHRNE-related_disorder', 'Congenital_myasthenic_syndrome', 'Congenital_myasthenic_syndrome_4A']
GAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTG...
GAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTG...
pathogenic
261,338
Mutation found at chromosome 17 position 4899335, gene CHRNE: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B', 'Congenital_myasthenic_syndrome_4C']
ACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAA...
ACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAA...
pathogenic
261,339
For chromosome 17, position 4899352, gene CHRNE: benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Congenital_myasthenic_syndrome_4A', 'Congenital_myasthenic_syndrome_4B']
GGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCT...
GGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCT...
pathogenic
261,341