question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Located at chromosome 1 position 25809138, the variant affecting gene SELENON (selenoprotein N)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Eichsfeld_type_congenital_muscular_dystrophy']
GGCGTACAGGGATTATAGGGATTACAGGTGTGAGCCACCATGCCCGGCCGGGAGCCCCTTTCTTAACCTCATCGCTGCAGGTTCAGGGAGGGACAGAAATTCCAAGGAGGAGCTCACAGGGAAGGGCATTGCCCGTTTTGGGTCCTGTTTACTTGCCGTCTCCCACTATAAGCTCCAAGAAGACAGGGTGCACAGTGTACCCTGATAGAAACTTCCTATACAGTAGGTGCATAAAACATTTTGTGGAATGAACAAATGAATAAACGTGTTCTTCTCAGCCAAGGAGACAGTGCAGCAGATAGGCAGGAGTCCAGGAAGTG...
GGCGTACAGGGATTATAGGGATTACAGGTGTGAGCCACCATGCCCGGCCGGGAGCCCCTTTCTTAACCTCATCGCTGCAGGTTCAGGGAGGGACAGAAATTCCAAGGAGGAGCTCACAGGGAAGGGCATTGCCCGTTTTGGGTCCTGTTTACTTGCCGTCTCCCACTATAAGCTCCAAGAAGACAGGGTGCACAGTGTACCCTGATAGAAACTTCCTATACAGTAGGTGCATAAAACATTTTGTGGAATGAACAAATGAATAAACGTGTTCTTCTCAGCCAAGGAGACAGTGCAGCAGATAGGCAGGAGTCCAGGAAGTG...
pathogenic
5,814
A genetic variant on chromosome 1, position 25809805, affects the gene SELENON (selenoprotein N). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Congenital_myopathy_with_fiber_type_disproportion', 'Eichsfeld_type_congenital_muscular_dystrophy']
TGCCAGGGAGGTGGCGACAGAAGAGGGAATCTGCTGTTCCCCAAATGCTGGCCGACGTGTAGACAGCTCTGTGGTCTCTGAGCGTCCTCTCCGAGCCATCAGCTTGTCAGACAGAGGCGAGGCAGGTCACCGATGAGGACTCGGGCTTAGGGAAGGCCTTTTGCCCAGGGTGGGGCAGGCTGTACTTAAGGCAGGGCCCTTCTGGGGGTGGCCTTCCTTCCCCTTCCCTGTGGTCTCATCCTGCTCTTGACCCTAGAGATTTCACCTCAAACATGATTGGCCACCACCCTCATCGGACTTAGCTCCAAACCGAAACCCTG...
TGCCAGGGAGGTGGCGACAGAAGAGGGAATCTGCTGTTCCCCAAATGCTGGCCGACGTGTAGACAGCTCTGTGGTCTCTGAGCGTCCTCTCCGAGCCATCAGCTTGTCAGACAGAGGCGAGGCAGGTCACCGATGAGGACTCGGGCTTAGGGAAGGCCTTTTGCCCAGGGTGGGGCAGGCTGTACTTAAGGCAGGGCCCTTCTGGGGGTGGCCTTCCTTCCCCTTCCCTGTGGTCTCATCCTGCTCTTGACCCTAGAGATTTCACCTCAAACATGATTGGCCACCACCCTCATCGGACTTAGCTCCAAACCGAAACCCTG...
pathogenic
5,819
Gene SELENON (selenoprotein N) variant at chromosome 1, position 25811806—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Eichsfeld_type_congenital_muscular_dystrophy']
CATCATCCTCTCCAAAGACGCCACCCACGTCCGCGACTTCCGGCTCTTCGTGCCCAACCACAGGTGGGAGCTTGACCCTGGCCCAGCCTTGGCTCCCTCCTACAGCTTGTCCTGCTCCCCAGCTCCAGGAGCCTAGGGGCCTCTTCTGTCTCTGCCCCTTCCTTTGCTCCCCAGAGCCCATCTCATGGGGCTGACGTGGCAGGAGGCGGCATGAGGCAGGCAAGAGAATGAGCTGATCACCCACCAGCTCTTCCCAGGCACCCGTGGCCTGGCCCTCCACCTCTGTGCCTGGGACCCAGTGCAGCAGTCCGCAGACCCTT...
CATCATCCTCTCCAAAGACGCCACCCACGTCCGCGACTTCCGGCTCTTCGTGCCCAACCACAGGTGGGAGCTTGACCCTGGCCCAGCCTTGGCTCCCTCCTACAGCTTGTCCTGCTCCCCAGCTCCAGGAGCCTAGGGGCCTCTTCTGTCTCTGCCCCTTCCTTTGCTCCCCAGAGCCCATCTCATGGGGCTGACGTGGCAGGAGGCGGCATGAGGCAGGCAAGAGAATGAGCTGATCACCCACCAGCTCTTCCCAGGCACCCGTGGCCTGGCCCTCCACCTCTGTGCCTGGGACCCAGTGCAGCAGTCCGCAGACCCTT...
pathogenic
5,833
Benign or pathogenic: chromosome 1, position 25812734, gene SELENON (selenoprotein N) variant? Disease(s) if pathogenic?
pathogenic; ['Eichsfeld_type_congenital_muscular_dystrophy']
ATTGCCCCTAGGAGTGGGGGTGGCTTCCCTCCCTCCCCAGAGTGGGAAGGGCAGGGGCTTCCCGGTCAAAGGGAAAAGGAAGAGGAGGGCACAAGCCCTCCATCTGCTCACCTAGGGCTGGGCACACCTGCCTCCATCGCAGGGTTGTTGAGGAGGGGGCCTGGACTGTATGGGACAGGAGGAGAGAGGCAGTGGCCAGCTCCAGGACCAGCTGTTCCTGGGCTCATGTCTGAGGACCAGGCACCAGGGACTGCTGACCCCCGGGGGTTACCTAGCTCTGCCCTCTGTGCCCCCTGCTGCGGAGGTGGTGGTTTGCCAGT...
ATTGCCCCTAGGAGTGGGGGTGGCTTCCCTCCCTCCCCAGAGTGGGAAGGGCAGGGGCTTCCCGGTCAAAGGGAAAAGGAAGAGGAGGGCACAAGCCCTCCATCTGCTCACCTAGGGCTGGGCACACCTGCCTCCATCGCAGGGTTGTTGAGGAGGGGGCCTGGACTGTATGGGACAGGAGGAGAGAGGCAGTGGCCAGCTCCAGGACCAGCTGTTCCTGGGCTCATGTCTGAGGACCAGGCACCAGGGACTGCTGACCCCCGGGGGTTACCTAGCTCTGCCCTCTGTGCCCCCTGCTGCGGAGGTGGTGGTTTGCCAGT...
pathogenic
5,841
Variant in SELENON (selenoprotein N), chromosome 1, position 25813938—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Abnormality_of_the_musculature', 'Congenital_myopathy_4A,_autosomal_dominant', 'Eichsfeld_type_congenital_muscular_dystrophy']
GCAGGGGTGAAGGCCAGGGTCAGGCTGCATGGGCAGAGGCTGGGAGCTGTGGAGCAGCAGCTGGGCACAGACGCTGGTATGTGTGCAGGGCTTGCTACTGAGGCTGTCTCACTGTTGGGCCCAGCTGTGCCAGCGGGGCCTCCCCGCTGCCATTCAGAACTTGGAGGAAGAGGCCAGGTGCAATGGCTCATGCCTATAATCCAAAACTTTGGGAGGCTGAGGCAGAGAATCACTTGTGGCCAGGAGTTCAAGAGCAATCTGGGCAACATAGCGAGACCCCATATCTACAAAAGAATTTTTTTAATTACCTGGGGGTGGTG...
GCAGGGGTGAAGGCCAGGGTCAGGCTGCATGGGCAGAGGCTGGGAGCTGTGGAGCAGCAGCTGGGCACAGACGCTGGTATGTGTGCAGGGCTTGCTACTGAGGCTGTCTCACTGTTGGGCCCAGCTGTGCCAGCGGGGCCTCCCCGCTGCCATTCAGAACTTGGAGGAAGAGGCCAGGTGCAATGGCTCATGCCTATAATCCAAAACTTTGGGAGGCTGAGGCAGAGAATCACTTGTGGCCAGGAGTTCAAGAGCAATCTGGGCAACATAGCGAGACCCCATATCTACAAAAGAATTTTTTTAATTACCTGGGGGTGGTG...
pathogenic
5,852
Does the variant impacting TRIM63 (tripartite motif containing 63) on chromosome 1, position 26061184, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Hypertrophic_cardiomyopathy', 'Inborn_genetic_diseases']
TGCCTCAGCCTCCCGAGTAGCTGGGATTATAGATACGCTACCACGCCTGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCACCCAGCTTGACCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGTGCCCAGCTCTCTGTTGCCTTTTAGCTGTGTTTCCCTTTTAGCTGTGTGACCTTCAACAAATTAACGTTTCCTGGGCCTCCCATATGTCCCAGTTCACACTCTTCCCTCCCTTTCAGGACCAAGACTGGATTCGGGAAGCTCT...
TGCCTCAGCCTCCCGAGTAGCTGGGATTATAGATACGCTACCACGCCTGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCACCCAGCTTGACCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGTGCCCAGCTCTCTGTTGCCTTTTAGCTGTGTTTCCCTTTTAGCTGTGTGACCTTCAACAAATTAACGTTTCCTGGGCCTCCCATATGTCCCAGTTCACACTCTTCCCTCCCTTTCAGGACCAAGACTGGATTCGGGAAGCTCT...
pathogenic
5,880
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 1, position 26183819, gene CNKSR1 (connector enhancer of kinase suppressor of Ras 1). What disease(s) is it linked to if pathogenic?
benign
GTCTCTGAGGTGAGTAATTGGTGAGTAATTGGCTCTGAGTGGTTAAGCATAGTCCCTTAACCACTGTGCTATTCTTCCCCTGCCAGGTACCTCTTCTCCCACTTAAATGATTTCTCAGCATGCCAGGAGATCCGAGACTTGTTGGAGGAGCTGAGCCAGGTCTTGCATGAGGTAGGAGAACCAAGGGCCAGGCTTGGCCCATGCCCTAGAGACCAAGCTGGGCTAGAGCTTTTTATAACCTGTGAATCAGCCCAGGATCGAGTATGAGGATTGAGACGGGCGAGAAAGGAGGAGAGGAGGCCCTGCCACTGGGTATGGGA...
GTCTCTGAGGTGAGTAATTGGTGAGTAATTGGCTCTGAGTGGTTAAGCATAGTCCCTTAACCACTGTGCTATTCTTCCCCTGCCAGGTACCTCTTCTCCCACTTAAATGATTTCTCAGCATGCCAGGAGATCCGAGACTTGTTGGAGGAGCTGAGCCAGGTCTTGCATGAGGTAGGAGAACCAAGGGCCAGGCTTGGCCCATGCCCTAGAGACCAAGCTGGGCTAGAGCTTTTTATAACCTGTGAATCAGCCCAGGATCGAGTATGAGGATTGAGACGGGCGAGAAAGGAGGAGAGGAGGCCCTGCCACTGGGTATGGGA...
benign
5,894
Does the variant impacting DHDDS (dehydrodolichyl diphosphate synthase subunit) on chromosome 1, position 26442810, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Retinitis_pigmentosa_59']
AGAGGCAGCTCTTCAGCTTGTTTCTTCTGTTCTGTTTGAATGTCTTCTGTTGTCTACGTTTAACCTCCCGCTCTCCATCTCTCAACATTGTCCTCCACCTCTCAACATTGTTCTCCACCTTTAGTGGTACAGGATTAGAGCAGCCCCAAAGGACTAAGTTTTCTTCTTTTTTTTTTTTTTTGAGACGGAGTGTTGCTCTGTCACCCAGGCTGGGGTGCAGTGGCGCGATCTCAGTTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAACTGGGATTACAGGCCTGCGCCACCAC...
AGAGGCAGCTCTTCAGCTTGTTTCTTCTGTTCTGTTTGAATGTCTTCTGTTGTCTACGTTTAACCTCCCGCTCTCCATCTCTCAACATTGTCCTCCACCTCTCAACATTGTTCTCCACCTTTAGTGGTACAGGATTAGAGCAGCCCCAAAGGACTAAGTTTTCTTCTTTTTTTTTTTTTTTGAGACGGAGTGTTGCTCTGTCACCCAGGCTGGGGTGCAGTGGCGCGATCTCAGTTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAACTGGGATTACAGGCCTGCGCCACCAC...
pathogenic
5,921
Variant in DHDDS (dehydrodolichyl diphosphate synthase subunit), chromosome 1, position 26460040—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Developmental_delay_and_seizures_with_or_without_movement_abnormalities', 'Retinitis_pigmentosa_59']
CCCAAACAGGCTGGGGCCAGAGTACTTCTGGGGAAAGCTAAAATCTGGAGAAGCATCTCTAGGCTGTGTCTCATAATATTTGATGTCCATTCCTCATCTGTCGCTGGCTTTGCGAATCCAACTATAGTGAAAACTTCATTGTGCCGCTTTTCAAGGAATGGGACTTCTGTCTTGCATCCCTGAGCGTAAGCTCTTGCCTTGGTAACCTGCCAGGGACCCTAGCCCCTCTGGGTTGGAAGCTTGCCTTGCAGTTACTAGTCCCTCCCCTTCAGGATAAAGGGCCATACCTATGCAAGCATGGTAAACAATATGCAAACACT...
CCCAAACAGGCTGGGGCCAGAGTACTTCTGGGGAAAGCTAAAATCTGGAGAAGCATCTCTAGGCTGTGTCTCATAATATTTGATGTCCATTCCTCATCTGTCGCTGGCTTTGCGAATCCAACTATAGTGAAAACTTCATTGTGCCGCTTTTCAAGGAATGGGACTTCTGTCTTGCATCCCTGAGCGTAAGCTCTTGCCTTGGTAACCTGCCAGGGACCCTAGCCCCTCTGGGTTGGAAGCTTGCCTTGCAGTTACTAGTCCCTCCCCTTCAGGATAAAGGGCCATACCTATGCAAGCATGGTAAACAATATGCAAACACT...
pathogenic
5,931
Is the genetic change at chromosome 1, position 26696421, within gene ARID1A (AT-rich interaction domain 1A) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Coffin-Siris_syndrome_1', 'Intellectual_disability,_autosomal_dominant_14']
GGCAGCCTTGGGTCTGGTGAGGAGCTGGAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGA...
GGCAGCCTTGGGTCTGGTGAGGAGCTGGAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGA...
pathogenic
5,939
Determine whether the variant at chromosome 1, position 26696448, in gene ARID1A (AT-rich interaction domain 1A) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
GAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTC...
GAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTC...
benign
5,940
Determine if the mutation at chromosome 1, position 26696448 in gene ARID1A (AT-rich interaction domain 1A) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
GAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTC...
GAATCCCCTCTGGCTTTTGTAGCCTGTCATATCAGAACATTCCAAGTCAGCCTGAGGAAGAAAAGGCTGCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTC...
benign
5,941
For chromosome 1, position 26696516, gene ARID1A (AT-rich interaction domain 1A): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
GCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTAT...
GCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTAT...
benign
5,943
Regarding the variant found on chromosome 1 at position 26696516 in gene ARID1A (AT-rich interaction domain 1A): is it benign or pathogenic? If pathogenic, identify the disease(s).
benign
GCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTAT...
GCTGCTGGGATTTGGTGGGGCCTGTAGATCAGGAGAACACTGGAGCTTTCTGTGTATGTCGATCTTTTCAGATAAACCTGGCCTTCTACCCAACTCCAGCTCAATCGGGGTCTCTTAGAATGTAATGGTAAACTTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTAT...
benign
5,944
Is the genetic change at chromosome 1, position 26696649, within gene ARID1A (AT-rich interaction domain 1A) benign or pathogenic? Name the disease(s) if pathogenic.
benign
TTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTATTAGAAGGTACTGTCTTTGGAGACTGGGGCTACTTGTCATGGTAGGCTAAGTTTTCTTAAGAGGGAGTGAGAAACGGTGTTTAGGTTTTCCTGCTGGGTAACTGTTCTATGCTCCTAAAGCAACTTCAGTGGCC...
TTTAAACAATCTTTACGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTATTAGAAGGTACTGTCTTTGGAGACTGGGGCTACTTGTCATGGTAGGCTAAGTTTTCTTAAGAGGGAGTGAGAAACGGTGTTTAGGTTTTCCTGCTGGGTAACTGTTCTATGCTCCTAAAGCAACTTCAGTGGCC...
benign
5,948
Variant in gene ARID1A (AT-rich interaction domain 1A), located at chromosome 1 position 26696664: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
CGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTATTAGAAGGTACTGTCTTTGGAGACTGGGGCTACTTGTCATGGTAGGCTAAGTTTTCTTAAGAGGGAGTGAGAAACGGTGTTTAGGTTTTCCTGCTGGGTAACTGTTCTATGCTCCTAAAGCAACTTCAGTGGCCTCCATTTTAAGTTAG...
CGCTACAGGATAGAAAACAAATCTGACAAGCATCCATTTTCTAAGTGACTTGTTGGACTGTGCCTTTTCTTCAAGGAGAAAATGGTTTCCATTTTCTGCATCTCTCTTCTGTAATGGTTTGAACACTCAGGTTCCTGCAGTCCCTGGAGCCTCTTCTGTGGGTTTTCAGTATTAGAAGGTACTGTCTTTGGAGACTGGGGCTACTTGTCATGGTAGGCTAAGTTTTCTTAAGAGGGAGTGAGAAACGGTGTTTAGGTTTTCCTGCTGGGTAACTGTTCTATGCTCCTAAAGCAACTTCAGTGGCCTCCATTTTAAGTTAG...
benign
5,949
Does the chromosome 1 mutation at position 26697412 within gene ARID1A classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Intellectual_disability,_autosomal_dominant_14']
GGGTCAGGGCTGGGCCGAGGCGGCCGCGGTCTCAGGCTCTGGCCAATTTTGCAGCCGCGGGTAAAGTTCACGCTGCCCGCTCCCCTCGGTACGGCCGGGAGGGGACAGACCTGGATAGGGACGCCGGGAGGGAGGCGGCGCAGGCTCCAGAGATGCGCGGGCTCCGGGCCGGGTTTTCTCCGAAGCCTTCGGCGGCGGCGCTGCCTAGCGAAAGCGGCTGAGGGCCTGCCGCCGCCGCGGCTTGTTCTCTCCCCTCCTCCTTTGTGAAGGGAAGGGAGCGAGTCCGTTCCACGGCCTGCGCCCGCTCCGCTCTCCACTCC...
GGGTCAGGGCTGGGCCGAGGCGGCCGCGGTCTCAGGCTCTGGCCAATTTTGCAGCCGCGGGTAAAGTTCACGCTGCCCGCTCCCCTCGGTACGGCCGGGAGGGGACAGACCTGGATAGGGACGCCGGGAGGGAGGCGGCGCAGGCTCCAGAGATGCGCGGGCTCCGGGCCGGGTTTTCTCCGAAGCCTTCGGCGGCGGCGCTGCCTAGCGAAAGCGGCTGAGGGCCTGCCGCCGCCGCGGCTTGTTCTCTCCCCTCCTCCTTTGTGAAGGGAAGGGAGCGAGTCCGTTCCACGGCCTGCGCCCGCTCCGCTCTCCACTCC...
pathogenic
5,978
A mutation at chromosome position 26697417 on chromosome 1 in gene ARID1A: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
AGGGCTGGGCCGAGGCGGCCGCGGTCTCAGGCTCTGGCCAATTTTGCAGCCGCGGGTAAAGTTCACGCTGCCCGCTCCCCTCGGTACGGCCGGGAGGGGACAGACCTGGATAGGGACGCCGGGAGGGAGGCGGCGCAGGCTCCAGAGATGCGCGGGCTCCGGGCCGGGTTTTCTCCGAAGCCTTCGGCGGCGGCGCTGCCTAGCGAAAGCGGCTGAGGGCCTGCCGCCGCCGCGGCTTGTTCTCTCCCCTCCTCCTTTGTGAAGGGAAGGGAGCGAGTCCGTTCCACGGCCTGCGCCCGCTCCGCTCTCCACTCCGGGTT...
AGGGCTGGGCCGAGGCGGCCGCGGTCTCAGGCTCTGGCCAATTTTGCAGCCGCGGGTAAAGTTCACGCTGCCCGCTCCCCTCGGTACGGCCGGGAGGGGACAGACCTGGATAGGGACGCCGGGAGGGAGGCGGCGCAGGCTCCAGAGATGCGCGGGCTCCGGGCCGGGTTTTCTCCGAAGCCTTCGGCGGCGGCGCTGCCTAGCGAAAGCGGCTGAGGGCCTGCCGCCGCCGCGGCTTGTTCTCTCCCCTCCTCCTTTGTGAAGGGAAGGGAGCGAGTCCGTTCCACGGCCTGCGCCCGCTCCGCTCTCCACTCCGGGTT...
benign
5,979
Gene ARID1A (AT-rich interaction domain 1A) variant at chromosome position 26773690 on chromosome 1: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
TCTGGGAGCTTTGGCCTATTGATGTCAGCACCTTAGAATGCAGCTCAGACTAGAGCCCTGAATTCCCCAGGGAGCTGAGATGGTAATGAATGGGAAGGAGGGAGTGGGGAAGGGTTATGAATGGAACTCCCTGATGGGAGTGGCTCTGCTCACCCTCCTTTCTGAGAGGAGGCTGAGGCCTAGGGTGAGCCTAGAGAGGGAAGAAGGCCAGGGTGCCTGGAAGGTGGGTGTAAACACATGTGCCCTGGTGTTGACCTCTGAGGGTGTAATGAGTGCCTGAGATGACTCATCAGCTGGGGAGGCCTCAGCAGTGGGATATC...
TCTGGGAGCTTTGGCCTATTGATGTCAGCACCTTAGAATGCAGCTCAGACTAGAGCCCTGAATTCCCCAGGGAGCTGAGATGGTAATGAATGGGAAGGAGGGAGTGGGGAAGGGTTATGAATGGAACTCCCTGATGGGAGTGGCTCTGCTCACCCTCCTTTCTGAGAGGAGGCTGAGGCCTAGGGTGAGCCTAGAGAGGGAAGAAGGCCAGGGTGCCTGGAAGGTGGGTGTAAACACATGTGCCCTGGTGTTGACCTCTGAGGGTGTAATGAGTGCCTGAGATGACTCATCAGCTGGGGAGGCCTCAGCAGTGGGATATC...
benign
6,035
Considering the variant on chromosome 1, location 26773690, involving gene ARID1A (AT-rich interaction domain 1A), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
benign
TCTGGGAGCTTTGGCCTATTGATGTCAGCACCTTAGAATGCAGCTCAGACTAGAGCCCTGAATTCCCCAGGGAGCTGAGATGGTAATGAATGGGAAGGAGGGAGTGGGGAAGGGTTATGAATGGAACTCCCTGATGGGAGTGGCTCTGCTCACCCTCCTTTCTGAGAGGAGGCTGAGGCCTAGGGTGAGCCTAGAGAGGGAAGAAGGCCAGGGTGCCTGGAAGGTGGGTGTAAACACATGTGCCCTGGTGTTGACCTCTGAGGGTGTAATGAGTGCCTGAGATGACTCATCAGCTGGGGAGGCCTCAGCAGTGGGATATC...
TCTGGGAGCTTTGGCCTATTGATGTCAGCACCTTAGAATGCAGCTCAGACTAGAGCCCTGAATTCCCCAGGGAGCTGAGATGGTAATGAATGGGAAGGAGGGAGTGGGGAAGGGTTATGAATGGAACTCCCTGATGGGAGTGGCTCTGCTCACCCTCCTTTCTGAGAGGAGGCTGAGGCCTAGGGTGAGCCTAGAGAGGGAAGAAGGCCAGGGTGCCTGGAAGGTGGGTGTAAACACATGTGCCCTGGTGTTGACCTCTGAGGGTGTAATGAGTGCCTGAGATGACTCATCAGCTGGGGAGGCCTCAGCAGTGGGATATC...
benign
6,036
Evaluate if the mutation on chromosome 1 at position 26779184 in ARID1A (AT-rich interaction domain 1A) is benign or pathogenic. Disease name(s) if pathogenic?
benign
CTCACTGCAGCCTCAAACTCCTGGGCTCAAGCGATCCTCTTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCAAATGCCACCATGTCCAGCTATTTATTTATTTTGAGACAGGGTCTCCATTACTCAAGCTAGAGTGCAGTGGTGCAATCACAGCTCACTGCAGTCTCAACTTCCGAGGCTCAGGTGATCCTCCCACCTCAGCTTCCCAAGTGGCTGGGACTACAGGTGCGTGCAAACATGCTCATGCTCAGCTAATTTTTTTTTTTTTTTTTTTTGAGAGATGAGGCTTCACCATGTTGCCCAGGCTGATTTCAAAC...
CTCACTGCAGCCTCAAACTCCTGGGCTCAAGCGATCCTCTTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCAAATGCCACCATGTCCAGCTATTTATTTATTTTGAGACAGGGTCTCCATTACTCAAGCTAGAGTGCAGTGGTGCAATCACAGCTCACTGCAGTCTCAACTTCCGAGGCTCAGGTGATCCTCCCACCTCAGCTTCCCAAGTGGCTGGGACTACAGGTGCGTGCAAACATGCTCATGCTCAGCTAATTTTTTTTTTTTTTTTTTTTGAGAGATGAGGCTTCACCATGTTGCCCAGGCTGATTTCAAAC...
benign
6,065
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 1, position 26779197, gene ARID1A (AT-rich interaction domain 1A). What disease(s) is it linked to if pathogenic?
benign
CAAACTCCTGGGCTCAAGCGATCCTCTTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCAAATGCCACCATGTCCAGCTATTTATTTATTTTGAGACAGGGTCTCCATTACTCAAGCTAGAGTGCAGTGGTGCAATCACAGCTCACTGCAGTCTCAACTTCCGAGGCTCAGGTGATCCTCCCACCTCAGCTTCCCAAGTGGCTGGGACTACAGGTGCGTGCAAACATGCTCATGCTCAGCTAATTTTTTTTTTTTTTTTTTTTGAGAGATGAGGCTTCACCATGTTGCCCAGGCTGATTTCAAACTCCTGGGCTCAAG...
CAAACTCCTGGGCTCAAGCGATCCTCTTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCAAATGCCACCATGTCCAGCTATTTATTTATTTTGAGACAGGGTCTCCATTACTCAAGCTAGAGTGCAGTGGTGCAATCACAGCTCACTGCAGTCTCAACTTCCGAGGCTCAGGTGATCCTCCCACCTCAGCTTCCCAAGTGGCTGGGACTACAGGTGCGTGCAAACATGCTCATGCTCAGCTAATTTTTTTTTTTTTTTTTTTTGAGAGATGAGGCTTCACCATGTTGCCCAGGCTGATTTCAAACTCCTGGGCTCAAG...
benign
6,066
Is the genetic mutation found on chromosome 1 at position 26780031, within the gene ARID1A (AT-rich interaction domain 1A), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['ARID1A-related_BAFopathy', 'Intellectual_disability,_autosomal_dominant_14']
ACTTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGGGACTCTGTCTCAAAAAAAAAAAAAAAAAAATACACACACACACACTCTCACACACTAGCCCGATGTGGTGGCAGGCGCCTGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAAAAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGCCAACTGAGATCACACCACTGTACTCCAGCCTGGATGACAGAGTGAGACTTCATCTCAAAAAAAAAAAAAAGTGTTGGGATTACAGGTGTGAGCCA...
ACTTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGGGACTCTGTCTCAAAAAAAAAAAAAAAAAAATACACACACACACACTCTCACACACTAGCCCGATGTGGTGGCAGGCGCCTGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAAAAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGCCAACTGAGATCACACCACTGTACTCCAGCCTGGATGACAGAGTGAGACTTCATCTCAAAAAAAAAAAAAAGTGTTGGGATTACAGGTGTGAGCCA...
pathogenic
6,078
The genetic variant at chromosome 1, position 27548841, affecting gene AHDC1 (AT-hook DNA binding motif containing 1): benign or pathogenic? Disease name(s) if pathogenic?
benign
GGTGCCAGCAGGGCTGGTCCTCTGGATAGGCCCTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTG...
GGTGCCAGCAGGGCTGGTCCTCTGGATAGGCCCTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTG...
benign
6,199
Clinical significance of chromosome 1, position 27548841, gene AHDC1 (AT-hook DNA binding motif containing 1): benign or pathogenic? Name the disease(s) if pathogenic.
benign
GGTGCCAGCAGGGCTGGTCCTCTGGATAGGCCCTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTG...
GGTGCCAGCAGGGCTGGTCCTCTGGATAGGCCCTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTG...
benign
6,200
Gene AHDC1 (AT-hook DNA binding motif containing 1) variant at chromosome position 27548873 on chromosome 1: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
CTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTGAATCCCTACACCCTGCTCTCAGTCCCCAGCCT...
CTGGGTAGACGACCGTCCAACCTGCTTCTCCCTTCACCTGTCTCACACAGGGCGATACAAATGCCCACCCTTATCAGCGTATTTCCTGGGAAATACTCACTTCCTGCCCAAGACATAGCATGAACAAATAATTGAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTGAATCCCTACACCCTGCTCTCAGTCCCCAGCCT...
benign
6,203
Is the chromosome 1, position 27549006 variant in AHDC1 (AT-hook DNA binding motif containing 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
GAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTGAATCCCTACACCCTGCTCTCAGTCCCCAGCCTTGCCCTTAAATCCTGCATTTGCTTCCTGCACTCCATACCTCTGTCCTTGCCTAAGCTCTGATGTCCTCTTCCCACCCCCAGGCCTCTGCCCACTGCGCCCACATCCCCAGACTCACCCAGGAACAAAACCTCG...
GAAAGCTTAATAAACCAAACTACAGGGCCCCATCCAGTGTGTAGTCCTCTGGCCATTTCAATTCACAAGACCCCCCCGAACGTTCAAGCCCCCTGCTGAGTTCCCAGCCCAAGCACCCCATCTCCTCCTGAGACTGTCCGCAACAGCGAATCCTGAATCCCTACACCCTGCTCTCAGTCCCCAGCCTTGCCCTTAAATCCTGCATTTGCTTCCTGCACTCCATACCTCTGTCCTTGCCTAAGCTCTGATGTCCTCTTCCCACCCCCAGGCCTCTGCCCACTGCGCCCACATCCCCAGACTCACCCAGGAACAAAACCTCG...
benign
6,207
Clinically, how would you classify the variant at chromosome 1, position 27549568, gene AHDC1 (AT-hook DNA binding motif containing 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome', 'Delayed_speech_and_language_development', 'Global_developmental_delay', 'Hypotonia', 'Intellectual_disability', 'Neonatal_hypotonia', 'Sleep_apnea']
AGCAGGGCCACGGGGTGGGCCAGGGGGCCGGGCCATTTCCAGTGGCTCCTTGTCGGCCTTGGGCGTGGCTGGTGGGCTAGCCAGGTGAGGGGCACTGAGGCACGCGGCCTCCGTCCTGCCCAGGAAGTCAGCCAGCAGCCCTGTACCCACCTTGCCTTCATAGGGCGGGCTGCGGGCAGCTGAGCCTGGAGGGTACCAATAGGCTGTGCCCTTGCAGCTGGGGGAATCGTAGTGGGGCTGGCCCAGCGGCAGGTCCCGGCAGCTCAGGTGGGCCTGGGCTGCAGCTGCGTGGCCCAGGCTGGCCCCCTGGAGTCCATGCT...
AGCAGGGCCACGGGGTGGGCCAGGGGGCCGGGCCATTTCCAGTGGCTCCTTGTCGGCCTTGGGCGTGGCTGGTGGGCTAGCCAGGTGAGGGGCACTGAGGCACGCGGCCTCCGTCCTGCCCAGGAAGTCAGCCAGCAGCCCTGTACCCACCTTGCCTTCATAGGGCGGGCTGCGGGCAGCTGAGCCTGGAGGGTACCAATAGGCTGTGCCCTTGCAGCTGGGGGAATCGTAGTGGGGCTGGCCCAGCGGCAGGTCCCGGCAGCTCAGGTGGGCCTGGGCTGCAGCTGCGTGGCCCAGGCTGGCCCCCTGGAGTCCATGCT...
pathogenic
6,231
Determine whether the variant at chromosome 1, position 27549741, in gene AHDC1 (AT-hook DNA binding motif containing 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome', 'Delayed_speech_and_language_development', 'Global_developmental_delay', 'Hypotonia', 'Intellectual_disability', 'Neonatal_hypotonia', 'Sleep_apnea']
GGGCAGCTGAGCCTGGAGGGTACCAATAGGCTGTGCCCTTGCAGCTGGGGGAATCGTAGTGGGGCTGGCCCAGCGGCAGGTCCCGGCAGCTCAGGTGGGCCTGGGCTGCAGCTGCGTGGCCCAGGCTGGCCCCCTGGAGTCCATGCTTGAGGGGCTCGCAGGCAGCCAGCTTTGTGGGCGGTGGCCGCAGCTCTTCCTTGAAGCCCAGTGTAGGCGAGCAGGTGGGCGAGTATGCCTTCTGCAGGCCGGCGTCAAACACCGTGGGTGGGTGGGCCAGCGGTGGGAAATGCTTGCCATCAAGCTCGGGAGCACCCAGGCTG...
GGGCAGCTGAGCCTGGAGGGTACCAATAGGCTGTGCCCTTGCAGCTGGGGGAATCGTAGTGGGGCTGGCCCAGCGGCAGGTCCCGGCAGCTCAGGTGGGCCTGGGCTGCAGCTGCGTGGCCCAGGCTGGCCCCCTGGAGTCCATGCTTGAGGGGCTCGCAGGCAGCCAGCTTTGTGGGCGGTGGCCGCAGCTCTTCCTTGAAGCCCAGTGTAGGCGAGCAGGTGGGCGAGTATGCCTTCTGCAGGCCGGCGTCAAACACCGTGGGTGGGTGGGCCAGCGGTGGGAAATGCTTGCCATCAAGCTCGGGAGCACCCAGGCTG...
pathogenic
6,236
Classify the chromosome 1 variant at position 27550357 affecting gene AHDC1 (AT-hook DNA binding motif containing 1) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome', 'Neurodevelopmental_abnormality']
CCGGGGCCCAGTGCTCCGTTTGGATGGGTAGCCTGAGGCAGCGGCAGAGGCGGATGTCGGGAAGCCCAGATGTGAGGCCTCGAACAGGTCCACCTTCTTCCGCCGTCCACGGCCCGGCTTGGAGCTACTCTGAAAGAGGACACTCTGGTTCCAGTTGTAGCCGGGGGCAGATGATGCCTCGTTCCAGTCCATCATCAGTTTCTCCAGGCTGGACAGGCTCGACTGGCCCTCACTACTTGAGGCCTCGCTGTTGGCACGCCGAAACCCCCCGCCACCAACCGGCTGATTGAACTGGGTGCTGTCGGAGGATGACTCAGAGA...
CCGGGGCCCAGTGCTCCGTTTGGATGGGTAGCCTGAGGCAGCGGCAGAGGCGGATGTCGGGAAGCCCAGATGTGAGGCCTCGAACAGGTCCACCTTCTTCCGCCGTCCACGGCCCGGCTTGGAGCTACTCTGAAAGAGGACACTCTGGTTCCAGTTGTAGCCGGGGGCAGATGATGCCTCGTTCCAGTCCATCATCAGTTTCTCCAGGCTGGACAGGCTCGACTGGCCCTCACTACTTGAGGCCTCGCTGTTGGCACGCCGAAACCCCCCGCCACCAACCGGCTGATTGAACTGGGTGCTGTCGGAGGATGACTCAGAGA...
pathogenic
6,250
Gene AHDC1 (AT-hook DNA binding motif containing 1) variant at chromosome 1, position 27550633—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome']
AACCGGCTGATTGAACTGGGTGCTGTCGGAGGATGACTCAGAGAAGGTCTCCGACACAGCCGTCTGCTGCTTCACCTTCTGCGGTGTGTAGTTGGAGATGTCCAGGATCACGTTGGGCTCGCTGACGTGGCAGTCAAAACTGGGATTGTAGAGCTGACTAAAGGCCTCTGAGGCCCAGTCCAGGCCTCCATAGCCCTGCCGGAAAGGCCACTGAGAAGCCCCCGCAAACTGCCGACAGTTCTCGGGCGAGGGCTGGAAGGAGGAGGAGGAGGAGGAGGCGGCAGAGGCTGCAGAGGTGGCAGAGGCTGTGGTGCCCTTGG...
AACCGGCTGATTGAACTGGGTGCTGTCGGAGGATGACTCAGAGAAGGTCTCCGACACAGCCGTCTGCTGCTTCACCTTCTGCGGTGTGTAGTTGGAGATGTCCAGGATCACGTTGGGCTCGCTGACGTGGCAGTCAAAACTGGGATTGTAGAGCTGACTAAAGGCCTCTGAGGCCCAGTCCAGGCCTCCATAGCCCTGCCGGAAAGGCCACTGAGAAGCCCCCGCAAACTGCCGACAGTTCTCGGGCGAGGGCTGGAAGGAGGAGGAGGAGGAGGAGGCGGCAGAGGCTGCAGAGGTGGCAGAGGCTGTGGTGCCCTTGG...
pathogenic
6,259
Clinical classification of chromosome 1, position 27550682, gene AHDC1 (AT-hook DNA binding motif containing 1): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome', 'Inborn_genetic_diseases']
TCCGACACAGCCGTCTGCTGCTTCACCTTCTGCGGTGTGTAGTTGGAGATGTCCAGGATCACGTTGGGCTCGCTGACGTGGCAGTCAAAACTGGGATTGTAGAGCTGACTAAAGGCCTCTGAGGCCCAGTCCAGGCCTCCATAGCCCTGCCGGAAAGGCCACTGAGAAGCCCCCGCAAACTGCCGACAGTTCTCGGGCGAGGGCTGGAAGGAGGAGGAGGAGGAGGAGGCGGCAGAGGCTGCAGAGGTGGCAGAGGCTGTGGTGCCCTTGGGTACCATGTAGCCACCGGGCGAGACTGTGCTGGCCCGGCTGTCACAGCG...
TCCGACACAGCCGTCTGCTGCTTCACCTTCTGCGGTGTGTAGTTGGAGATGTCCAGGATCACGTTGGGCTCGCTGACGTGGCAGTCAAAACTGGGATTGTAGAGCTGACTAAAGGCCTCTGAGGCCCAGTCCAGGCCTCCATAGCCCTGCCGGAAAGGCCACTGAGAAGCCCCCGCAAACTGCCGACAGTTCTCGGGCGAGGGCTGGAAGGAGGAGGAGGAGGAGGAGGCGGCAGAGGCTGCAGAGGTGGCAGAGGCTGTGGTGCCCTTGGGTACCATGTAGCCACCGGGCGAGACTGTGCTGGCCCGGCTGTCACAGCG...
pathogenic
6,262
Variant at chromosome 1, position 27550993, gene AHDC1 (AT-hook DNA binding motif containing 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['AHDC1-related_disorder', 'AHDC1-related_intellectual_disability_-_obstructive_sleep_apnea_-_mild_dysmorphism_syndrome']
GTCACAGCGCAGGGGCGTGGGGGCTGAACCAGAGAAGGGGGCCCCCTCAGAGCTGCTGAAGAAGGAGGCCTTGCTTGGTGGCAGGCAGGGGCCCCCGGTAGGCGGTGGGGCATAGCCGGCGCTGTGGGCGCTGCTGGGTGAGGCAGGGAGGCTGTTGCCACTGCCATAGGCGAAGCTGCAGTCCTTGCTGTTAGCGCAGTCCTGGCCTGTAAAGGGCTTAGTTGGGGCGAATACGCTTTGTCCGGCCCCATAGCCGCCGTACTGGGGCAGGTAGGTGTTGGCAGGCGGGTGGGTGGTAGGTGAGCGGGCCATGGCTGAGG...
GTCACAGCGCAGGGGCGTGGGGGCTGAACCAGAGAAGGGGGCCCCCTCAGAGCTGCTGAAGAAGGAGGCCTTGCTTGGTGGCAGGCAGGGGCCCCCGGTAGGCGGTGGGGCATAGCCGGCGCTGTGGGCGCTGCTGGGTGAGGCAGGGAGGCTGTTGCCACTGCCATAGGCGAAGCTGCAGTCCTTGCTGTTAGCGCAGTCCTGGCCTGTAAAGGGCTTAGTTGGGGCGAATACGCTTTGTCCGGCCCCATAGCCGCCGTACTGGGGCAGGTAGGTGTTGGCAGGCGGGTGGGTGGTAGGTGAGCGGGCCATGGCTGAGG...
pathogenic
6,270
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 1, position 29200513, gene MECR (mitochondrial trans-2-enoyl-CoA reductase). What disease(s) is it linked to if pathogenic?
pathogenic; ['Childhood_Onset_Dystonias', 'Dystonia,_childhood-onset,_with_optic_atrophy_and_basal_ganglia_abnormalities', 'Mitochondrial_disease', 'Optic_atrophy', 'Optic_atrophy_16']
TCCCCCTGCAATGACATTGGGATTGAGGTCTGCCGCAGGGGTTGTCTGTCAGGTATAGGGCTGAAGCGGTGTGCTCAAATGTGGGGTCAAGCCTGGCTCTCCTGCTGCCTAGACTTTGGGACAGGTACTTGACCTCTTTGGGCCTTGTTTTTTTTTGTTTGTTTGTTTTTGAGACACACTGTTTCTCTGAAGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACGACCATGCCTGGCTAAT...
TCCCCCTGCAATGACATTGGGATTGAGGTCTGCCGCAGGGGTTGTCTGTCAGGTATAGGGCTGAAGCGGTGTGCTCAAATGTGGGGTCAAGCCTGGCTCTCCTGCTGCCTAGACTTTGGGACAGGTACTTGACCTCTTTGGGCCTTGTTTTTTTTTGTTTGTTTGTTTTTGAGACACACTGTTTCTCTGAAGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACGACCATGCCTGGCTAAT...
pathogenic
6,343
Chromosome 1, position 29216611, gene MECR (mitochondrial trans-2-enoyl-CoA reductase): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Childhood_Onset_Dystonias', 'Dystonia,_childhood-onset,_with_optic_atrophy_and_basal_ganglia_abnormalities', 'Optic_atrophy']
TGTTGGCCAGGCTAGTCTTGAACTCCTGATCTCAGGTGATCCACCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCCCAACTTCTTTTTTTAAAGCAAGTTTGAGCTGGGTCGCTGTAAGTTACAACCCAGAAGATCATAACACTGGTGTGTAATGGGAACCCAGGAGAAAGAATCCAGTGGGCACTCTCATTTTGCTGTTTGACTTTGGGCCAGGGCTTTACTTCTCAAGCTTCAATTTATGTCCAATGGATGGATAATACCTGCCCTGCTTCCCTCTTGTAGCTGCTGTGAGGATC...
TGTTGGCCAGGCTAGTCTTGAACTCCTGATCTCAGGTGATCCACCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCCCAACTTCTTTTTTTAAAGCAAGTTTGAGCTGGGTCGCTGTAAGTTACAACCCAGAAGATCATAACACTGGTGTGTAATGGGAACCCAGGAGAAAGAATCCAGTGGGCACTCTCATTTTGCTGTTTGACTTTGGGCCAGGGCTTTACTTCTCAAGCTTCAATTTATGTCCAATGGATGGATAATACCTGCCCTGCTTCCCTCTTGTAGCTGCTGTGAGGATC...
pathogenic
6,363
The genetic variant at chromosome 1, position 30936879, affecting gene PUM1 (pumilio RNA binding family member 1): benign or pathogenic? Disease name(s) if pathogenic?
benign
CCCTAACAAGCCACACACACACATGTTGAACTCCATTTTTTATTGGATTTAACAAGAAGTGAAACGTTAATTACCTGCTTCTCTCCTTATGTCCCTTTTGCTGAAAAGGATACCACTTAGTAATGGAAGAGCTGAAAAACTAAGAGGGCTTCTCAGGACTCTCCCCGTCAACTCCCTCAGCCAACCAACTGCTAAGCCCTACCAATTCTAGCACCCTATTCTGTCCACTTCTCTTCAATCCCAAACCACCACCATCTGGTGCCTTGACGGCCTCCCATGTGGTCTCATCACTGCCTCCCTCCTCTAAACTACAAAGGCCA...
CCCTAACAAGCCACACACACACATGTTGAACTCCATTTTTTATTGGATTTAACAAGAAGTGAAACGTTAATTACCTGCTTCTCTCCTTATGTCCCTTTTGCTGAAAAGGATACCACTTAGTAATGGAAGAGCTGAAAAACTAAGAGGGCTTCTCAGGACTCTCCCCGTCAACTCCCTCAGCCAACCAACTGCTAAGCCCTACCAATTCTAGCACCCTATTCTGTCCACTTCTCTTCAATCCCAAACCACCACCATCTGGTGCCTTGACGGCCTCCCATGTGGTCTCATCACTGCCTCCCTCCTCTAAACTACAAAGGCCA...
benign
6,374
A mutation at chromosome position 32786922 on chromosome 1 in gene YARS1: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
GTGCCTAACACATGGGCACCTAGTAAGTCTTTTGTTCAAGTGTCTGTTGAAATGAATAGGAGCCTCTATTCTGTCCTTTTATAATTATCTCTTGTTTTTGAATCCTGATTTTGCATCTGTTCCTGAAATACTTCATTTTTGCTGAGTTAGGTCCTTTATTCCAGCCTGCTAAGTCATTTGGAGAGTGATTAAAGCACCAGTATATTAGCATTGTACCATTTGCCTATCGAATCTGGGAACCACCTGAATCCTCATCAAAGCCATTAACAAAATATGCAGCCCTGGAGAGCATAAACAGAGCCCTGGCCGGGCACAGGGGC...
GTGCCTAACACATGGGCACCTAGTAAGTCTTTTGTTCAAGTGTCTGTTGAAATGAATAGGAGCCTCTATTCTGTCCTTTTATAATTATCTCTTGTTTTTGAATCCTGATTTTGCATCTGTTCCTGAAATACTTCATTTTTGCTGAGTTAGGTCCTTTATTCCAGCCTGCTAAGTCATTTGGAGAGTGATTAAAGCACCAGTATATTAGCATTGTACCATTTGCCTATCGAATCTGGGAACCACCTGAATCCTCATCAAAGCCATTAACAAAATATGCAGCCCTGGAGAGCATAAACAGAGCCCTGGCCGGGCACAGGGGC...
benign
6,474
Clinically, how would you classify the variant at chromosome 1, position 33036744, gene AK2: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Reticular_dysgenesis']
CTATACTAGTATAGGTTGTCCATTCCATAATTACTGAAATTATTAACTTCAATATGAGTTAAGAAAAAAATCTCAGGGCATAGTGGCTTGTGCCTATAATCCCTGCACTTTGGGAGGTCAAGGCAGGATGATCGCCTGTGTCCAGGAGTTCAATACCAGCCTGGGCAACATAGCAAGACCCTGTCTCTACAAAAAATTGTTTAAAAATTAGCTGGGCATGGTAGCATGTGCCTGTACTCCCAGCTACCTGGGAGGGTGAGGTGGGAGGATTGCTTGAGCTCACACCACTGCGCTCCAACCTGGGCAACAGAGTGAGACCC...
CTATACTAGTATAGGTTGTCCATTCCATAATTACTGAAATTATTAACTTCAATATGAGTTAAGAAAAAAATCTCAGGGCATAGTGGCTTGTGCCTATAATCCCTGCACTTTGGGAGGTCAAGGCAGGATGATCGCCTGTGTCCAGGAGTTCAATACCAGCCTGGGCAACATAGCAAGACCCTGTCTCTACAAAAAATTGTTTAAAAATTAGCTGGGCATGGTAGCATGTGCCTGTACTCCCAGCTACCTGGGAGGGTGAGGTGGGAGGATTGCTTGAGCTCACACCACTGCGCTCCAACCTGGGCAACAGAGTGAGACCC...
pathogenic
6,529
Gene mutation in GJB4 (gap junction protein beta 4) at chromosome 1, position 34761406—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
AGACCTCAGTATCAGGCTTCCCAGGAAAAGGGCAGGAGAGAGGGCAAGGAGGCAGGGTAAGGAGGCAATGGGAAGGGGACAGGGTCAATCCCACTGGTGCTGTCCTAGGCCTAGGCATAATGATATCAGGCTCCTGAACCCCACACAGCAGTCTCACCCACATACCTGCCTGCCTGGGAGCCAGGCTCAGCCATACCCAGCCAGGCTAGAGAGGAGGCGTGGGCCAGGAGAGAAGAGCCGCAGGTGTTTGCTCTGAGTATGTGCCCGGGGAAGTCCGCCCTCCTGCCTGCCCACCCAATCACTCTCGCTTGGCTCATTGG...
AGACCTCAGTATCAGGCTTCCCAGGAAAAGGGCAGGAGAGAGGGCAAGGAGGCAGGGTAAGGAGGCAATGGGAAGGGGACAGGGTCAATCCCACTGGTGCTGTCCTAGGCCTAGGCATAATGATATCAGGCTCCTGAACCCCACACAGCAGTCTCACCCACATACCTGCCTGCCTGGGAGCCAGGCTCAGCCATACCCAGCCAGGCTAGAGAGGAGGCGTGGGCCAGGAGAGAAGAGCCGCAGGTGTTTGCTCTGAGTATGTGCCCGGGGAAGTCCGCCCTCCTGCCTGCCCACCCAATCACTCTCGCTTGGCTCATTGG...
benign
6,543
Evaluate this variant at chromosome 1, position 35901573, gene AGO1 (argonaute RISC component 1): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['AGO1-related_disorder', 'Intellectual_disability', 'likely other unspecified diseases']
TAGTCTTTTGCTAGTGTTAATTCTGTATCTTTAACCACCTGTAGAGAATGCTACAACTTTAAGGCACCTTTAAGAGAGCAATCTCACAAATTTCAATAATTTTGGATTTTCATTACGTGAATTGACTATTTTGTTTATTCTCTGGAATATGGAGTTTGAAGGCAGGTGACCTTGGGCTGGTTTTCCTTCCCATTGTTTACCATGAACTCTGGGAATTAGGACGAGAACTAGTATGTAAAGAATGTTGGCCCTATGGGAGCAAGTTCCTCATTTCATCTCATCTAAATCCTTACAACAAACTCATGAGACAGCTAGTGTAT...
TAGTCTTTTGCTAGTGTTAATTCTGTATCTTTAACCACCTGTAGAGAATGCTACAACTTTAAGGCACCTTTAAGAGAGCAATCTCACAAATTTCAATAATTTTGGATTTTCATTACGTGAATTGACTATTTTGTTTATTCTCTGGAATATGGAGTTTGAAGGCAGGTGACCTTGGGCTGGTTTTCCTTCCCATTGTTTACCATGAACTCTGGGAATTAGGACGAGAACTAGTATGTAAAGAATGTTGGCCCTATGGGAGCAAGTTCCTCATTTCATCTCATCTAAATCCTTACAACAAACTCATGAGACAGCTAGTGTAT...
pathogenic
6,611
Gene RSPO1 (R-spondin 1) variant at chromosome 1, position 37612794—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
benign
GTAATTAAAATTAATTTCACCTCATTCCTTTTTATACTGTGGCTACTAGAAAAACATTTTCTTTTTTTATTACTTAATTTTGTTTTGCACACCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCCTCCTGTCTTTGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCCTGCCTGGCATTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAGCCTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCGAGTAGCTG...
GTAATTAAAATTAATTTCACCTCATTCCTTTTTATACTGTGGCTACTAGAAAAACATTTTCTTTTTTTATTACTTAATTTTGTTTTGCACACCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCCTCCTGTCTTTGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCCTGCCTGGCATTTTTTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAGCCTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCGAGTAGCTG...
benign
6,714
Mutation at chromosome 1, position 39084245, within MACF1 (microtubule actin crosslinking factor 1): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
CCGAGGGTCGGGCGGGAGCCCGGAGGTCAAACAAGTGTTTGTGAGGGGCCGGAGATTGACGGGGTAGAGCCCAGAAGGGACGCTTTCTCCGGGAGGAGGCCTTGGGAGAGCCGGCCTTTGTAGTGAAATGGGCGTCTTGGAGAGGAATGGGCGGTTCTGGGATGAAGCAGGTGGTCTGAGAGGAGGGGCATTTTTCCTGCCCCCGAGCTGAGGGTAGGGATGGAAGCTTGGCCTGAGTTTCCCAGAGGTTGAGGCTGTCACTTCAGCACCTGCCCTGGCACTAGAAGGTAATGGGAGGAGGGGTAAGTGCTAAGATAAAG...
CCGAGGGTCGGGCGGGAGCCCGGAGGTCAAACAAGTGTTTGTGAGGGGCCGGAGATTGACGGGGTAGAGCCCAGAAGGGACGCTTTCTCCGGGAGGAGGCCTTGGGAGAGCCGGCCTTTGTAGTGAAATGGGCGTCTTGGAGAGGAATGGGCGGTTCTGGGATGAAGCAGGTGGTCTGAGAGGAGGGGCATTTTTCCTGCCCCCGAGCTGAGGGTAGGGATGGAAGCTTGGCCTGAGTTTCCCAGAGGTTGAGGCTGTCACTTCAGCACCTGCCCTGGCACTAGAAGGTAATGGGAGGAGGGGTAAGTGCTAAGATAAAG...
benign
6,759
Variant at chromosome position 39844617, chromosome 1, gene TRIT1 (tRNA isopentenyltransferase 1): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Combined_oxidative_phosphorylation_deficiency_35']
GAAGGAAGTCAAGCTTTAGGGCCACTGTTGCCTGCTATCAACTGCTGACCTGTCACCCCTAAGACAGTTCCCACCTTCTGACTAACTCATACAGATTTATTTTCACTATCCTGTTCTTTTTTCAAGGAAATCTCATCTGGGAACACTGAAAGAGATGGACAACTAGTTTAAATTCTCTTTTATACATATTAAAAACATCATTTTTAAGAGTTTAGAAGCAAGAATAAGTAAGGTAGAGGTTAGAATTAAGAGAAAAGTTTACTTGGGGAAGAAGTCAGCTTTGTTTTCCAGCTAGAGCCTAAGGCAAAAAACGGGCTTCT...
GAAGGAAGTCAAGCTTTAGGGCCACTGTTGCCTGCTATCAACTGCTGACCTGTCACCCCTAAGACAGTTCCCACCTTCTGACTAACTCATACAGATTTATTTTCACTATCCTGTTCTTTTTTCAAGGAAATCTCATCTGGGAACACTGAAAGAGATGGACAACTAGTTTAAATTCTCTTTTATACATATTAAAAACATCATTTTTAAGAGTTTAGAAGCAAGAATAAGTAAGGTAGAGGTTAGAATTAAGAGAAAAGTTTACTTGGGGAAGAAGTCAGCTTTGTTTTCCAGCTAGAGCCTAAGGCAAAAAACGGGCTTCT...
pathogenic
6,917
Is the genetic variant on chromosome 1, position 39852872, gene TRIT1 (tRNA isopentenyltransferase 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Inborn_genetic_diseases', 'Mitochondrial_disease']
GCATGTTGTACATCCAGCTCATCAGCTTTCTTTTTAAATATGTCAAATTAATGAAGAATGCTCCTGGCTAATCCAGTGCTCTACTGGCACAAAGATCACTGAGAAAAGAACTCACATACTTATTCTTAAGCCACCATCCACTTCTGTCCGTATCTATTATGTTATGCAGCACTAGGTAATTTAACTCCCAAATCTACACTCTACCACTCTGGGTGATTGCAACTTATCAGCCTGAAAGTGATCTTTCTCTTCCTGACCCAATTCTACTTCCTGAAACCCTAACGCAAGAGTGTAGACCCCCTTGTCTTTCAGTATCACTG...
GCATGTTGTACATCCAGCTCATCAGCTTTCTTTTTAAATATGTCAAATTAATGAAGAATGCTCCTGGCTAATCCAGTGCTCTACTGGCACAAAGATCACTGAGAAAAGAACTCACATACTTATTCTTAAGCCACCATCCACTTCTGTCCGTATCTATTATGTTATGCAGCACTAGGTAATTTAACTCCCAAATCTACACTCTACCACTCTGGGTGATTGCAACTTATCAGCCTGAAAGTGATCTTTCTCTTCCTGACCCAATTCTACTTCCTGAAACCCTAACGCAAGAGTGTAGACCCCCTTGTCTTTCAGTATCACTG...
pathogenic
6,925
Is the genetic variant on chromosome 1, position 39854049, gene TRIT1 (tRNA isopentenyltransferase 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Combined_oxidative_phosphorylation_deficiency_35', 'Epileptic_encephalopathy', 'TRIT1_Deficiency']
CTAACATTAAGTTTCACTGAGGGGGGTAAAATTAGGAGGAAAAATATCAAATTCATTTGAGTGGAATACTTCACAACCCCTATGAATATGAGATGTTACTTTAATATTTAATCTGTATAACCATCAATAGAACAGGTCCTTCATTAGATGTTCTACTATGCTGGAAGTGGTATCACTCCTAATACTGCAGAAAAATAAACCTAACATGAGGCTGCAATTCCAAAACAACCTAAAAAAACATGACCTTGTGAGTTCATTCACTACCTCTCTTCCCTACCAGATAGTTTCCATGTGCAAAGGTGAGCTGATCTGTGAGACAG...
CTAACATTAAGTTTCACTGAGGGGGGTAAAATTAGGAGGAAAAATATCAAATTCATTTGAGTGGAATACTTCACAACCCCTATGAATATGAGATGTTACTTTAATATTTAATCTGTATAACCATCAATAGAACAGGTCCTTCATTAGATGTTCTACTATGCTGGAAGTGGTATCACTCCTAATACTGCAGAAAAATAAACCTAACATGAGGCTGCAATTCCAAAACAACCTAAAAAAACATGACCTTGTGAGTTCATTCACTACCTCTCTTCCCTACCAGATAGTTTCCATGTGCAAAGGTGAGCTGATCTGTGAGACAG...
pathogenic
6,928
Is chromosome 1, position 40073531, gene PPT1 (palmitoyl-protein thioesterase 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
CTATGGAACGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAAGCGAAGTGCCACTGGGTTCTTTGCCCTCCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTTCTAGATTTCCTCTACCTTTTTGCTCTTAAAACTGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTTGGGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGA...
CTATGGAACGGGCAGAAGTTGGTCACCACAGTGACAGAAATTGCTGGATAAGCGAAGTGCCACTGGGTTCTTTGCCCTCCCTTCACACCATGGGATAAATCTGTATCAAGACGGTTCTTTTCTAGATTTCCTCTACCTTTTTGCTCTTAAAACTGCTTCTCTGCTCTGAGAAGCACAGCTACCTGCCTTCACTGAAATATACCTCAGGCTGAAATTTGGGGTGGGATAGCAGGTCAGTTGATCTTCTGCAGGAAGGTGCAGCTTTTCCATATCAGCTCAACCACGCCGCCAGTCCATTCTTAAGGAACTGCCGACTAGGA...
benign
6,961
The chromosome 1, position 40074171 genetic variant in gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
GAGATAGGAGAGTCTCTGGTACTAGCTGCTGTAGCAGTGCCCTTCATCCAGGGCAGTTAATGGAGTCTTGGACCCTTTCTTTCTCTGGGATCCCTGCCCAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAAAAAACCCACATGATTTCAAGGAGTCTGGCATTCCTGAATCCTTCTTCCCTGCCAGGTGCCTGTCACCTGTCTTCACTGCCTCCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCTAAGCACCTGAACAGAGGACTGAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGA...
GAGATAGGAGAGTCTCTGGTACTAGCTGCTGTAGCAGTGCCCTTCATCCAGGGCAGTTAATGGAGTCTTGGACCCTTTCTTTCTCTGGGATCCCTGCCCAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAAAAAACCCACATGATTTCAAGGAGTCTGGCATTCCTGAATCCTTCTTCCCTGCCAGGTGCCTGTCACCTGTCTTCACTGCCTCCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCTAAGCACCTGAACAGAGGACTGAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGA...
pathogenic
6,968
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 40074182, gene PPT1 (palmitoyl-protein thioesterase 1): what disease(s) if pathogenic?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
GTCTCTGGTACTAGCTGCTGTAGCAGTGCCCTTCATCCAGGGCAGTTAATGGAGTCTTGGACCCTTTCTTTCTCTGGGATCCCTGCCCAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAAAAAACCCACATGATTTCAAGGAGTCTGGCATTCCTGAATCCTTCTTCCCTGCCAGGTGCCTGTCACCTGTCTTCACTGCCTCCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCTAAGCACCTGAACAGAGGACTGAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGAATTATGTAAGA...
GTCTCTGGTACTAGCTGCTGTAGCAGTGCCCTTCATCCAGGGCAGTTAATGGAGTCTTGGACCCTTTCTTTCTCTGGGATCCCTGCCCAGCACCTTCCTATAGAGATGACTTTAAAAGGAAAAAAAAAAAAAAAAAAACCCACATGATTTCAAGGAGTCTGGCATTCCTGAATCCTTCTTCCCTGCCAGGTGCCTGTCACCTGTCTTCACTGCCTCCTTTTCCCTGTCATGCTCATCAGCTTATGGCTTCTGTCTAAGCACCTGAACAGAGGACTGAAACCTCCACTGCAGGCTGGTTTTAGGTCTTGAATTATGTAAGA...
pathogenic
6,969
Regarding the variant found on chromosome 1 at position 40076863 in gene PPT1 (palmitoyl-protein thioesterase 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
ATACAGTGTTCTAGATTCTGATTTTTGAAAAGCTCAGAGTCAGAGGACTACCTATAGGTGGGCAAGCCATAGACGACACTGCCTCAGAATGCCATAGGTAAGTGGGACTGAGCCAAAGACAGAACATTAGCTAGGTAACTTAAAAAACATCCAACCCAGGACAGGCGCGGTGGCTCACGCCTATAATCCCAGCACTTTGGATGGCCAAGGCAGGCGGATCACCTGTGGTCAGGAGTTCAAGACCAGCCTGACCAATATGATGACACTTTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCGGGCACCTGTA...
ATACAGTGTTCTAGATTCTGATTTTTGAAAAGCTCAGAGTCAGAGGACTACCTATAGGTGGGCAAGCCATAGACGACACTGCCTCAGAATGCCATAGGTAAGTGGGACTGAGCCAAAGACAGAACATTAGCTAGGTAACTTAAAAAACATCCAACCCAGGACAGGCGCGGTGGCTCACGCCTATAATCCCAGCACTTTGGATGGCCAAGGCAGGCGGATCACCTGTGGTCAGGAGTTCAAGACCAGCCTGACCAATATGATGACACTTTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCGGGCACCTGTA...
pathogenic
6,975
Evaluate if the mutation on chromosome 1 at position 40078564 in PPT1 (palmitoyl-protein thioesterase 1) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
GTAGCAGACTGTACCTCAGCCAAGGCAGCTAGTTTTAAAACCTTTTTATCAAAAGAAGGGAATCAGACATGAGGTTTCTCTTGTTGTTTGGAAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCC...
GTAGCAGACTGTACCTCAGCCAAGGCAGCTAGTTTTAAAACCTTTTTATCAAAAGAAGGGAATCAGACATGAGGTTTCTCTTGTTGTTTGGAAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCC...
pathogenic
6,980
Clinical significance of chromosome 1, position 40078632, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
ATGAGGTTTCTCTTGTTGTTTGGAAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCCAGTTACCTGTGTGTACAGGGAGGTCTCCTGTAAGGGAATGGTTTCCTTGGCTTGGCCACTTCTGTAAA...
ATGAGGTTTCTCTTGTTGTTTGGAAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCCAGTTACCTGTGTGTACAGGGAGGTCTCCTGTAAGGGAATGGTTTCCTTGGCTTGGCCACTTCTGTAAA...
pathogenic
6,984
The mutation impacting PPT1 (palmitoyl-protein thioesterase 1) on chromosome 1 at position 40078655: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
AAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCCAGTTACCTGTGTGTACAGGGAGGTCTCCTGTAAGGGAATGGTTTCCTTGGCTTGGCCACTTCTGTAAAATCCAAACCACTGCAGAAGAAGC...
AAACCATAAGGTTTCAGGATGTAGTGGATTTTTGTAACCCAGTGCCTAATAAGCTAGAGCACATAATCAAGAGCCTAACAAGCTTCACCCATATTGGACATGAGTCAGGTGTTTCAGGAGTACCTAGTGCTCTGAGGTGTAAAGGAAAGGGCTCCAGCACCAAAGAACATAGCAGCTTCAGGAACTGGGAGCTGAAAAAACACCAACCTCCCAAGATAGACTCCCTGCCAGTTACCTGTGTGTACAGGGAGGTCTCCTGTAAGGGAATGGTTTCCTTGGCTTGGCCACTTCTGTAAAATCCAAACCACTGCAGAAGAAGC...
pathogenic
6,987
Gene PPT1 (palmitoyl-protein thioesterase 1) variant at chromosome 1, position 40089490—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
CATGTTGGCCAGGCTGGTCTTGAACTCCAGGCCTCAAGTGATCTGCCTACCAAGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACTGCGCCCCGCCTTAATCAGTATTTAGGTGTCACTTGTCACCCCCCGACGGACTGCTCACTTAGCATCACTAACAGAATTCTGATCGCCAAGGGTTGTTTTGGTTCACACAAAGAAAGAAAAGTATAGGCGTTTTGGAGGCAACTGGGCAAGAGTGAGAATAAAGAGTAAAGGAAGAAGAATGAAGTTTAAATACCATGCAAATCCATGAGAACAGAGAATATGTAGAATA...
CATGTTGGCCAGGCTGGTCTTGAACTCCAGGCCTCAAGTGATCTGCCTACCAAGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACTGCGCCCCGCCTTAATCAGTATTTAGGTGTCACTTGTCACCCCCCGACGGACTGCTCACTTAGCATCACTAACAGAATTCTGATCGCCAAGGGTTGTTTTGGTTCACACAAAGAAAGAAAAGTATAGGCGTTTTGGAGGCAACTGGGCAAGAGTGAGAATAAAGAGTAAAGGAAGAAGAATGAAGTTTAAATACCATGCAAATCCATGAGAACAGAGAATATGTAGAATA...
pathogenic
7,010
Mutation found at chromosome 1 position 40091320, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GCGAAACTCCATCTCAAAAAAAAAGATCTCATTTGAATATCACAAGGAACTACTGCTGGAATCACTGTGAGCATGAAAGTCAGCATGATATTTTCACACGGTGACAGGTCTGTAATCTTTTCAGCTAACCATACATACCGTTCCTGAACAACTTTGGAGTACGCCCCAGCATTCAGTGTTTTTCGGATGAAGTCACAGATGTGAGAGCTCTCTCCTGGGCATCGAGGGAGTCCAAAAACACCTACAGTGGTAGATGACAAATATCCACTCCTTCAATAATGATGTATCGAATACCCACTATGCACAAGGCACTGTGAGAA...
GCGAAACTCCATCTCAAAAAAAAAGATCTCATTTGAATATCACAAGGAACTACTGCTGGAATCACTGTGAGCATGAAAGTCAGCATGATATTTTCACACGGTGACAGGTCTGTAATCTTTTCAGCTAACCATACATACCGTTCCTGAACAACTTTGGAGTACGCCCCAGCATTCAGTGTTTTTCGGATGAAGTCACAGATGTGAGAGCTCTCTCCTGGGCATCGAGGGAGTCCAAAAACACCTACAGTGGTAGATGACAAATATCCACTCCTTCAATAATGATGTATCGAATACCCACTATGCACAAGGCACTGTGAGAA...
benign
7,016
Determine whether the variant at chromosome 1, position 40091363, in gene PPT1 (palmitoyl-protein thioesterase 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Neuronal_ceroid_lipofuscinosis', 'Neuronal_ceroid_lipofuscinosis_1']
AAGGAACTACTGCTGGAATCACTGTGAGCATGAAAGTCAGCATGATATTTTCACACGGTGACAGGTCTGTAATCTTTTCAGCTAACCATACATACCGTTCCTGAACAACTTTGGAGTACGCCCCAGCATTCAGTGTTTTTCGGATGAAGTCACAGATGTGAGAGCTCTCTCCTGGGCATCGAGGGAGTCCAAAAACACCTACAGTGGTAGATGACAAATATCCACTCCTTCAATAATGATGTATCGAATACCCACTATGCACAAGGCACTGTGAGAAACAAAATGAACAGGACCAAACTCTGATTTCATTCACTTATTCC...
AAGGAACTACTGCTGGAATCACTGTGAGCATGAAAGTCAGCATGATATTTTCACACGGTGACAGGTCTGTAATCTTTTCAGCTAACCATACATACCGTTCCTGAACAACTTTGGAGTACGCCCCAGCATTCAGTGTTTTTCGGATGAAGTCACAGATGTGAGAGCTCTCTCCTGGGCATCGAGGGAGTCCAAAAACACCTACAGTGGTAGATGACAAATATCCACTCCTTCAATAATGATGTATCGAATACCCACTATGCACAAGGCACTGTGAGAAACAAAATGAACAGGACCAAACTCTGATTTCATTCACTTATTCC...
pathogenic
7,021
Located at chromosome 1 position 40092068, the variant affecting gene PPT1 (palmitoyl-protein thioesterase 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
TAAATACCTTGTCCAAGGTTAGACAATAAGGTATAAGCCAGGATTCAGACACAGGCAGTTTGGCCCCAGAGCCCACTCCTTTAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTAT...
TAAATACCTTGTCCAAGGTTAGACAATAAGGTATAAGCCAGGATTCAGACACAGGCAGTTTGGCCCCAGAGCCCACTCCTTTAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTAT...
pathogenic
7,031
Is the variant located on chromosome 1 at position 40092109, gene PPT1 (palmitoyl-protein thioesterase 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
GATTCAGACACAGGCAGTTTGGCCCCAGAGCCCACTCCTTTAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTATATATATATATGTGTGTGTGTATATATGTGTATATAAGTGCA...
GATTCAGACACAGGCAGTTTGGCCCCAGAGCCCACTCCTTTAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTATATATATATATGTGTGTGTGTATATATGTGTATATAAGTGCA...
pathogenic
7,034
Variant at chromosome position 40092149, chromosome 1, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Neuronal_ceroid_lipofuscinosis', 'Neuronal_ceroid_lipofuscinosis_1']
TAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTATATATATATATGTGTGTGTGTATATATGTGTATATAAGTGCATATGTGTGTATATATATGTCTATATATGTCTATGTATGTG...
TAAGCACTACAACCACTAGTGTGTCCTTCGAACAGTATCCTGTTGTTTTTTTCCAAGAGATTGGGTCTTGCTATGTTGCCTAGACTAAAGTGCAATGGCTATTCACAGGCACAATTACAGCACACCACAGTGTCTTGAACTCCTGGCTTCAAATGATCCTCCAGCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTACACCACCATGTGCCCAGCTATCCTCCATTTTATCGTGTATATATATATATGTGTGTGTGTATATATGTGTATATAAGTGCATATGTGTGTATATATATGTCTATATATGTCTATGTATGTG...
pathogenic
7,036
Clinically, how would you classify the variant at chromosome 1, position 40092447, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
TCTATATATGTCTATGTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCT...
TCTATATATGTCTATGTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCT...
pathogenic
7,044
Mutation found at chromosome 1 position 40092456, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
GTCTATGTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCTGTGAGTGGA...
GTCTATGTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCTGTGAGTGGA...
pathogenic
7,046
Determine if the mutation at chromosome 1, position 40092462 in gene PPT1 (palmitoyl-protein thioesterase 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Neuronal_ceroid_lipofuscinosis', 'Neuronal_ceroid_lipofuscinosis_1']
GTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCTGTGAGTGGAACCTAA...
GTATGTGTGTATATAGGTGCATATGTGTATATATATGTCTATGTATGTATGTGCATATATGTGCACATGTGTGTGTGTATATATATATATTTCATGAATGCAAGAACCTTGTCTGTCTTGTTCCTGGCATATAATAGGTTTTCAATAAATATTTGTTAAATGAATGAATAATAAAGCTGTTTTTACCAACTTACGTTTGTATAATCCTTATACTTTTAAAAAGTATTTTCCTACCTATTATTTCACTTTATCCTCTGAAAAATTCCCATAGGACAGGCAGGGCCATATTTTGGTTTCTTCCATCTGTGAGTGGAACCTAA...
pathogenic
7,047
Is chromosome 1, position 40097197, gene PPT1 (palmitoyl-protein thioesterase 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
CATGACCTATCAACATTTGATGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACAT...
CATGACCTATCAACATTTGATGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACAT...
pathogenic
7,054
Variant in gene PPT1 (palmitoyl-protein thioesterase 1), located at chromosome 1 position 40097197: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
CATGACCTATCAACATTTGATGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACAT...
CATGACCTATCAACATTTGATGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACAT...
pathogenic
7,055
Clinically, how would you classify the variant at chromosome 1, position 40097217, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1', 'PPT1-related_disorder']
TGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACATCTCCTGGGTGTCTCATGAGG...
TGCAGTTGATCATGCCCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACATCTCCTGGGTGTCTCATGAGG...
pathogenic
7,058
Variant chromosome 1, position 40097232, gene PPT1 (palmitoyl-protein thioesterase 1): benign or pathogenic? Disease(s)?
pathogenic; ['Neuronal_ceroid_lipofuscinosis_1']
CCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACATCTCCTGGGTGTCTCATGAGGATCTCAAGTTTAGTA...
CCTTCTTCCTGAAACATTTTCTTCACTTGGCTTCAAGGACACTGCGCTTTCCTGACCCCTCCACTTCACCGGCTATTTGGTTACAGCCTCCTTTGCTAGTTTCTCCTCATTTCCTCCACCTCCAAATGGAATGGAGTGCCTCAGGGCTTAGTCCTCTGTGTACGCTCATTTCCTAGGTGGTCTCACCTAGCCTTTAACTACTAGCTGTATGCCGAAGACTCCCTACTTAAATCTCCAACCCGTATCTCTGTCCTAGACTCCACACTCCAAATGCCTCTACAACATCTCCTGGGTGTCTCATGAGGATCTCAAGTTTAGTA...
pathogenic
7,060
Mutation at chromosome 1, position 40258319, within ZMPSTE24: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Lethal_tight_skin_contracture_syndrome']
TAAATTCAAATAGTTGCAATGGATGTAAATTCTTGCAAATTGTAAATACTGACATTTTAAGATAAAACTGTTAAATCACTCTTTATAATGTATCCAAGAGAATCTACATAACAACTGAATAACCACCATTATGCATTAAAACATACACTAATGAGCTCTTCAACATTGTTCTTTTATTATCTCTAACATATTTAGATTGTACTCTAACAAAAAATGTTATTCAAATATAGTACTTTGATGTTTGAACAACCTTTTCTTGATCACTTCTTCGCAATAAAAATATGACATATGTAGTAAACCTTAAAAAATTTCGTGTAACT...
TAAATTCAAATAGTTGCAATGGATGTAAATTCTTGCAAATTGTAAATACTGACATTTTAAGATAAAACTGTTAAATCACTCTTTATAATGTATCCAAGAGAATCTACATAACAACTGAATAACCACCATTATGCATTAAAACATACACTAATGAGCTCTTCAACATTGTTCTTTTATTATCTCTAACATATTTAGATTGTACTCTAACAAAAAATGTTATTCAAATATAGTACTTTGATGTTTGAACAACCTTTTCTTGATCACTTCTTCGCAATAAAAATATGACATATGTAGTAAACCTTAAAAAATTTCGTGTAACT...
pathogenic
7,075
Variant chromosome 1, position 40290870, gene ZMPSTE24 (zinc metallopeptidase STE24): benign or pathogenic? Disease(s)?
pathogenic; ['Lethal_tight_skin_contracture_syndrome', 'Mandibuloacral_dysplasia_with_type_B_lipodystrophy', 'Restrictive_dermopathy_1', 'ZMPSTE24-related_disorder']
ATAATTCAGCCGAACCATTTTTTTCCCACTGCCAATAAATTAGGATATATATCCTTGCCTCAGGCTCTCTCTCCTCCCAGGCTGAGTAGACAGTGAGATATACACCTTAAAGTTCACCTCACCGAGAGTAATTCCCTTCACCACTGCCTTCCAAGACCATCCCTGAGTGGCTCTGTAATACCACAGCAGTCCACTTTCATCTGGTGCCAGCATATTGTATTAAGTTATTGTAAAATAGGCTCTGATTTTGTTCCTGTTCAACTAATTGATTATAGGGAACAGCATATGAGTAAGGGTTGGTTGAGGGTTGTTGGTGGTAG...
ATAATTCAGCCGAACCATTTTTTTCCCACTGCCAATAAATTAGGATATATATCCTTGCCTCAGGCTCTCTCTCCTCCCAGGCTGAGTAGACAGTGAGATATACACCTTAAAGTTCACCTCACCGAGAGTAATTCCCTTCACCACTGCCTTCCAAGACCATCCCTGAGTGGCTCTGTAATACCACAGCAGTCCACTTTCATCTGGTGCCAGCATATTGTATTAAGTTATTGTAAAATAGGCTCTGATTTTGTTCCTGTTCAACTAATTGATTATAGGGAACAGCATATGAGTAAGGGTTGGTTGAGGGTTGTTGGTGGTAG...
pathogenic
7,092
Chromosome 1, position 40290925, gene ZMPSTE24 (zinc metallopeptidase STE24): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Mandibuloacral_dysplasia_with_type_B_lipodystrophy', 'ZMPSTE24-related_disorder']
TGCCTCAGGCTCTCTCTCCTCCCAGGCTGAGTAGACAGTGAGATATACACCTTAAAGTTCACCTCACCGAGAGTAATTCCCTTCACCACTGCCTTCCAAGACCATCCCTGAGTGGCTCTGTAATACCACAGCAGTCCACTTTCATCTGGTGCCAGCATATTGTATTAAGTTATTGTAAAATAGGCTCTGATTTTGTTCCTGTTCAACTAATTGATTATAGGGAACAGCATATGAGTAAGGGTTGGTTGAGGGTTGTTGGTGGTAGGAGTTGGTGTACTAGAGTATGAGCCATCTGCTTATTTAACTTACTGGTGCCTTCA...
TGCCTCAGGCTCTCTCTCCTCCCAGGCTGAGTAGACAGTGAGATATACACCTTAAAGTTCACCTCACCGAGAGTAATTCCCTTCACCACTGCCTTCCAAGACCATCCCTGAGTGGCTCTGTAATACCACAGCAGTCCACTTTCATCTGGTGCCAGCATATTGTATTAAGTTATTGTAAAATAGGCTCTGATTTTGTTCCTGTTCAACTAATTGATTATAGGGAACAGCATATGAGTAAGGGTTGGTTGAGGGTTGTTGGTGGTAGGAGTTGGTGTACTAGAGTATGAGCCATCTGCTTATTTAACTTACTGGTGCCTTCA...
pathogenic
7,093
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 40302811, gene COL9A2 (collagen type IX alpha 2 chain): what disease(s) if pathogenic?
benign
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
benign
7,117
A genetic alteration at chromosome 1, position 40302811, in gene COL9A2 (collagen type IX alpha 2 chain)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
benign
7,118
Gene COL9A2 (collagen type IX alpha 2 chain) variant at chromosome 1, position 40302811—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
benign
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
CAGTCATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGG...
benign
7,119
Considering the genetic mutation at chromosome 1, position 40302816, impacting COL9A2 (collagen type IX alpha 2 chain): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
ATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGGGGAGA...
ATTGGTCCTCAAGCTGAGGGGTGGAACTGTAGCTGGGCAGGGCCCGGGCCTCCCGAGGTGCCCATGTCCCACTGACCCAAGGACAAGATGGCCAGTGGAGAAAGGTGCAGATTAAGATGTTTGTTTTGGTAACAGCCGAATGATGCTCGCTGGAAGGAAAGCCGCCCTATTCCTTCAGCGCTTCGACTCCATCGACACCACTTGCCCTGTGTGTTGGCCTCACTTTTTCACCCATCAGTGCTCTACCTCCCCTTCCCCCATGTTTTAGAATTCCTTTTCCTTAGGACTCCTGAGTCCCAGACAGAAGGTCCTGGGGGAGA...
benign
7,120
The chromosome 1, position 40303571 genetic variant in gene COL9A2 (collagen type IX alpha 2 chain): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Epiphyseal_dysplasia,_multiple,_2', 'Stickler_syndrome,_type_5']
TGTGATTGTCCCCTACCCCCAGCTCCCAATCAGTGAGCTTTGGGAGCAAACATCCCTTCCATCACCTCTGTGAAGTGATGGTGGTGGATCCTGGGAAGTCCTGAGAGGCCCAGCTTCCAGAGCTGGAACCACCCAGAGACTCCGGGGTGCTCCAAAGGGGTGCAGAAGCTGGGTATCAAGGACTGAGCTGGCTGAGCGTGAGGCCGCCATGGAGGAGACCGCAGTGTCCACACGTCATTAATTCCCAAGCTGAGGAACACACTGCAGCTGGGCAGGGCCAATGGCTTACCTGGGATCCCTGGGGGCCCAGGCATCCCGGG...
TGTGATTGTCCCCTACCCCCAGCTCCCAATCAGTGAGCTTTGGGAGCAAACATCCCTTCCATCACCTCTGTGAAGTGATGGTGGTGGATCCTGGGAAGTCCTGAGAGGCCCAGCTTCCAGAGCTGGAACCACCCAGAGACTCCGGGGTGCTCCAAAGGGGTGCAGAAGCTGGGTATCAAGGACTGAGCTGGCTGAGCGTGAGGCCGCCATGGAGGAGACCGCAGTGTCCACACGTCATTAATTCCCAAGCTGAGGAACACACTGCAGCTGGGCAGGGCCAATGGCTTACCTGGGATCCCTGGGGGCCCAGGCATCCCGGG...
pathogenic
7,128
Does the variant impacting COL9A2 (collagen type IX alpha 2 chain) on chromosome 1, position 40307477, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
TGTTTAGTGAATGTTTATGCAATGAATAAATGAACGAACAACTCTGCCTGTTGGATTCCCAGCCCATCAACTTGGCCATCTAGGAAAGTCACACTCCAGAACAGAGCCAGTCCCCACCCTCCCTGCAATGTACATAGGGAAACAGGCCCAGGGAGGAGAAAGAGCTTCCCTGAATCATTGGGTCAGGGCAGAGCCAGACTAACTCGGAGCTCTCCCTAGGTTAGGGCTCCACCCCATGGCCTCACCCTAAAGCAGGAACCCTTGTGTCAGTGCAGGGGGCATTTACCTCTTTCCCAGGGGGACCAGAGAATCCAGGAAGG...
TGTTTAGTGAATGTTTATGCAATGAATAAATGAACGAACAACTCTGCCTGTTGGATTCCCAGCCCATCAACTTGGCCATCTAGGAAAGTCACACTCCAGAACAGAGCCAGTCCCCACCCTCCCTGCAATGTACATAGGGAAACAGGCCCAGGGAGGAGAAAGAGCTTCCCTGAATCATTGGGTCAGGGCAGAGCCAGACTAACTCGGAGCTCTCCCTAGGTTAGGGCTCCACCCCATGGCCTCACCCTAAAGCAGGAACCCTTGTGTCAGTGCAGGGGGCATTTACCTCTTTCCCAGGGGGACCAGAGAATCCAGGAAGG...
benign
7,159
Evaluate if the mutation on chromosome 1 at position 40311460 in COL9A2 (collagen type IX alpha 2 chain) is benign or pathogenic. Disease name(s) if pathogenic?
benign
CCCCAACAGGTCTATTAATTGGGAAAAAAAAAAAAAAAGAGTTAAGAGAACTGGGATCGAGACCAAATCCCATTAGCCCCATGGCTGATTTGCTGGAATCTCATTGTCTGGCCCCAGTGACCATGGGACTGGATCCCAGGGCTTCGCCTAAAGTCTGAATTTGGGCTGACTGGGCTCTTGGCACAGATGGTCCTCCCCAGCAGGTCACCCACTTGGGCAGACACACACACACTCACTCACACACACATACATACACTCACAGTCACACACACACACTCAGAGATATCCTCACACACTCACATACACATACTACACACACT...
CCCCAACAGGTCTATTAATTGGGAAAAAAAAAAAAAAAGAGTTAAGAGAACTGGGATCGAGACCAAATCCCATTAGCCCCATGGCTGATTTGCTGGAATCTCATTGTCTGGCCCCAGTGACCATGGGACTGGATCCCAGGGCTTCGCCTAAAGTCTGAATTTGGGCTGACTGGGCTCTTGGCACAGATGGTCCTCCCCAGCAGGTCACCCACTTGGGCAGACACACACACACTCACTCACACACACATACATACACTCACAGTCACACACACACACTCAGAGATATCCTCACACACTCACATACACATACTACACACACT...
benign
7,182
Variant at chromosome position 40819438, chromosome 1, gene KCNQ4 (potassium voltage-gated channel subfamily Q member 4): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_2A', 'Nonsyndromic_genetic_hearing_loss', 'likely other unspecified diseases']
TGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAGGGGGGCTGTGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAAGGGGGCTGTGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAGGGGGGCCGTGTGAGGTGGCACCTCTGGGCTGAGGGCTGAAGGTGGAAAGAGGCTTCTCATACCATGGCTCAGAGAGCAGCTTGCTGTGCTGTGTTCCCTCAGCTGTGGCTGCCCCTCTCTGGGCATCATCTCCACTTTATAGCAAGTGTTGGGGGACCTCCTGCCTCTATGCAAGGGCTTATGATGG...
TGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAGGGGGGCTGTGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAAGGGGGCTGTGTGAGGTAGCACCTCTGGGCTGGGAGTCCGGGACTGAGGGGGGCCGTGTGAGGTGGCACCTCTGGGCTGAGGGCTGAAGGTGGAAAGAGGCTTCTCATACCATGGCTCAGAGAGCAGCTTGCTGTGCTGTGTTCCCTCAGCTGTGGCTGCCCCTCTCTGGGCATCATCTCCACTTTATAGCAAGTGTTGGGGGACCTCCTGCCTCTATGCAAGGGCTTATGATGG...
pathogenic
7,242
Is chromosome 1, position 40822298, gene KCNQ4 (potassium voltage-gated channel subfamily Q member 4) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
ACCTCATCCAGGTACAAGATGCCCGGGAAGAAGCCCTAGGAGCAGGGCCGTGTGACTGCACTGGTGTGTCAACCCTGTGTGCTGACCCATGTCCCCAGCCCAACTGTGACACCACTTTGAAGCTCAAAAGGGCTATGTGACTTTCCTGGAGCCACATGCCAAGTCACACACAGAGCCAGGATGCTCACTGACAGTGCCAGAAACTTCCCCCTGCACCAAATGCCTGGTTTAGGGCTAGCCAGAACTGCCCTATTGCCCAACTCCAGCCCAACTTCACAGGGCCTGGGGAGGGGCGGAGCCCAGACAGGAGCTGGGAGGCC...
ACCTCATCCAGGTACAAGATGCCCGGGAAGAAGCCCTAGGAGCAGGGCCGTGTGACTGCACTGGTGTGTCAACCCTGTGTGCTGACCCATGTCCCCAGCCCAACTGTGACACCACTTTGAAGCTCAAAAGGGCTATGTGACTTTCCTGGAGCCACATGCCAAGTCACACACAGAGCCAGGATGCTCACTGACAGTGCCAGAAACTTCCCCCTGCACCAAATGCCTGGTTTAGGGCTAGCCAGAACTGCCCTATTGCCCAACTCCAGCCCAACTTCACAGGGCCTGGGGAGGGGCGGAGCCCAGACAGGAGCTGGGAGGCC...
benign
7,260
Clinical impact (benign or pathogenic) of the variant at chromosome 1, location 41001009, gene CTPS1 (CTP synthase 1): what disease(s) if pathogenic?
benign
ATCCACTTGGAGTTAGTCTGTGGCTGCCATGTGTTTGTCAGGTGGCAGAGGATGAGAGATGGATGAAAAGGCAACGGTCTCCGCCTTTAAGGAATATTGAGTCTCTTAGGAAGGAAGGAGCACATAGGAGAGGCTGAACCTGCTGTGGCAGACACATGAGGAAGGCAGACTTCCTCATGGAGGGACACCAGGTTGGGTTGGGTAGGATGGAGAAGGCTCGGAAGGGGCATTCCTGTTAGAATAGATAGAGCACGTCCAAGGGCTTGGAGATGTGGAGCAGTTGGAAACACTGTGGATGGAAATTGTGAATTGGAGGCTGT...
ATCCACTTGGAGTTAGTCTGTGGCTGCCATGTGTTTGTCAGGTGGCAGAGGATGAGAGATGGATGAAAAGGCAACGGTCTCCGCCTTTAAGGAATATTGAGTCTCTTAGGAAGGAAGGAGCACATAGGAGAGGCTGAACCTGCTGTGGCAGACACATGAGGAAGGCAGACTTCCTCATGGAGGGACACCAGGTTGGGTTGGGTAGGATGGAGAAGGCTCGGAAGGGGCATTCCTGTTAGAATAGATAGAGCACGTCCAAGGGCTTGGAGATGTGGAGCAGTTGGAAACACTGTGGATGGAAATTGTGAATTGGAGGCTGT...
benign
7,298
Clinical significance of chromosome 1, position 42738274, gene CLDN19 (claudin 19): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Renal_hypomagnesemia_5_with_ocular_involvement']
CAGGGTGACCCGGCCTGGGGTAGGCGTGAAGGCTAGAGGCTGGGCCTCCAGCTCCTGCTCTGAGCAACCTTGGGCTCATTTCCTGATCTGGCCAGTGGAGGGGGCATGGGAGGGCCTGAGAGGTCTGCACGGGAGGAGTGGGGCAATCCCTGCCATGTTTTTTCCCAGTCACATTCTGGCCCACAGAACTCCCAGCCAAGACTGCTCCCGCTGCCCTCTGGAGAAGGCCAGACCCTTCCACCTGGCACTCTGGGCTCTCCACACCCAGACCCTGCTGGCCAGGCCAGCCCTGCTCCTGGTTCTCACTGCCTTGGTGCCTT...
CAGGGTGACCCGGCCTGGGGTAGGCGTGAAGGCTAGAGGCTGGGCCTCCAGCTCCTGCTCTGAGCAACCTTGGGCTCATTTCCTGATCTGGCCAGTGGAGGGGGCATGGGAGGGCCTGAGAGGTCTGCACGGGAGGAGTGGGGCAATCCCTGCCATGTTTTTTCCCAGTCACATTCTGGCCCACAGAACTCCCAGCCAAGACTGCTCCCGCTGCCCTCTGGAGAAGGCCAGACCCTTCCACCTGGCACTCTGGGCTCTCCACACCCAGACCCTGCTGGCCAGGCCAGCCCTGCTCCTGGTTCTCACTGCCTTGGTGCCTT...
pathogenic
7,340
A genetic variant at chromosome 1, position 42746753, affecting gene P3H1 (prolyl 3-hydroxylase 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Osteogenesis_imperfecta_type_8']
TTTGAGATGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCA...
TTTGAGATGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCA...
pathogenic
7,351
Regarding the variant found on chromosome 1 at position 42746753 in gene P3H1 (prolyl 3-hydroxylase 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Osteogenesis_imperfecta_type_8']
TTTGAGATGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCA...
TTTGAGATGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCA...
pathogenic
7,352
Evaluate if the mutation on chromosome 1 at position 42746776 in P3H1 (prolyl 3-hydroxylase 1) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Osteogenesis_imperfecta_type_8', 'Osteogenesis_imperfecta_type_III']
TTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCACTCAGGCTGGAGTGCAATGGAGC...
TTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAATGATTATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCACTCAGGCTGGAGTGCAATGGAGC...
pathogenic
7,354
Is chromosome 1, position 42746845, gene P3H1 (prolyl 3-hydroxylase 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Osteogenesis_imperfecta_type_8']
TATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCACTCAGGCTGGAGTGCAATGGAGCAGGCTTGACGTCCTGGGCTCATGATCCTCCTACCTCAGCCTCCTTAGTATTGGGACCACAGGTGTGCAT...
TATCTCGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCCAGGCTGGTCTCGACCTCCTGACCTTGGGTGAGCCACCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAAAGACCAGCCTTGTTCTTTCTTTGAGACATGGTCTTGCTCTGTCACTCAGGCTGGAGTGCAATGGAGCAGGCTTGACGTCCTGGGCTCATGATCCTCCTACCTCAGCCTCCTTAGTATTGGGACCACAGGTGTGCAT...
pathogenic
7,356
Assess the variant on chromosome 1, position 42747346, impacting P3H1 (prolyl 3-hydroxylase 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Osteogenesis_imperfecta', 'Osteogenesis_imperfecta_type_III']
CCAATCCATCAGCAATGCCTGTTGGCTCTACTTTAAAAATAGGCCCCCAGACACCCCTGACAATCCACCACTTTCCTTTTTATTTGTTTTTAGAGTTGGGATCTTGCTTTCTTGTGAAGGCTGGAGTGCAGTCGGGCGATCATAGCTCACTGCAGCCTCGAACTTCCAGGCTCAAGCGATCTTCCTGCCTCAGCGTCCAGCTGGGACTACAGGCACGTGACACGTCTCCTGGCTAATGTCACCATACTCTTTCTTGACCAATCTACACCGCCACATTGGCTTCCTTGTTTTTCCTCCACCTTGGACCCTGACTTGTTTTA...
CCAATCCATCAGCAATGCCTGTTGGCTCTACTTTAAAAATAGGCCCCCAGACACCCCTGACAATCCACCACTTTCCTTTTTATTTGTTTTTAGAGTTGGGATCTTGCTTTCTTGTGAAGGCTGGAGTGCAGTCGGGCGATCATAGCTCACTGCAGCCTCGAACTTCCAGGCTCAAGCGATCTTCCTGCCTCAGCGTCCAGCTGGGACTACAGGCACGTGACACGTCTCCTGGCTAATGTCACCATACTCTTTCTTGACCAATCTACACCGCCACATTGGCTTCCTTGTTTTTCCTCCACCTTGGACCCTGACTTGTTTTA...
pathogenic
7,367
The mutation impacting P3H1 (prolyl 3-hydroxylase 1) on chromosome 1 at position 42747780: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Osteogenesis_imperfecta_type_8']
GTTCACTGCCACGTTCCCAGCACCAGGCACTTAGCTGGTGCTCAGTAAATACATATTGATTGATGGAAGAAGTGAACACTCATGTGCAGGTTCCTACACTCAACGCCCTGTGGCATCTCAAGCACAGTAAAAGCTCTGGACCTAGTACCAGGGATGTAGCCAGAGGAGCTGAATCTCCATTTCCAGTGTTTCCTAGAGTGTGTCTTCCTGCACAGGGAGGCCGAGATACAGGACACTGAGGCCAGACGGCAGAGCAGGAAGCATGTGGCTGACATAGGGGTGACGTGCCAGAGCACTGCTGACCGCCGCTCCCTGCCAGA...
GTTCACTGCCACGTTCCCAGCACCAGGCACTTAGCTGGTGCTCAGTAAATACATATTGATTGATGGAAGAAGTGAACACTCATGTGCAGGTTCCTACACTCAACGCCCTGTGGCATCTCAAGCACAGTAAAAGCTCTGGACCTAGTACCAGGGATGTAGCCAGAGGAGCTGAATCTCCATTTCCAGTGTTTCCTAGAGTGTGTCTTCCTGCACAGGGAGGCCGAGATACAGGACACTGAGGCCAGACGGCAGAGCAGGAAGCATGTGGCTGACATAGGGGTGACGTGCCAGAGCACTGCTGACCGCCGCTCCCTGCCAGA...
pathogenic
7,372
Mutation found at chromosome 1 position 42750238, gene P3H1 (prolyl 3-hydroxylase 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Osteogenesis_imperfecta', 'Osteogenesis_imperfecta_type_8']
CCGCACTCACCTGTAGTCGCGGAAGGTGTAGGCTGGGGGCTCTTTGACACACACGAGGGTCTCGGCATTCAGGATGCAGTTGTCCACGTGGACTGGATGACTATCATCCTTCCTCTCTGCCTGGACCTCTGGGGCCAATGTCACACATGTTAGCAAGGGAGCACCTCGGGAGACGGCATAGCTCTCTTCTTGGCAGGGGAGGTGCTTCCCAAAATGTGTTTGAGTCTACGGAATGCCCAATGAACTAGGGGGGTGTCTTTGGCTAAGCCACAAGCCTAGGGGTCAGGACAAGTCTGCAGGCTTCCTAGGACAGTTCTTGG...
CCGCACTCACCTGTAGTCGCGGAAGGTGTAGGCTGGGGGCTCTTTGACACACACGAGGGTCTCGGCATTCAGGATGCAGTTGTCCACGTGGACTGGATGACTATCATCCTTCCTCTCTGCCTGGACCTCTGGGGCCAATGTCACACATGTTAGCAAGGGAGCACCTCGGGAGACGGCATAGCTCTCTTCTTGGCAGGGGAGGTGCTTCCCAAAATGTGTTTGAGTCTACGGAATGCCCAATGAACTAGGGGGGTGTCTTTGGCTAAGCCACAAGCCTAGGGGTCAGGACAAGTCTGCAGGCTTCCTAGGACAGTTCTTGG...
pathogenic
7,383
Classify the chromosome 1 variant at position 42752620 affecting gene P3H1 (prolyl 3-hydroxylase 1) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Osteogenesis_imperfecta_type_8']
GGCGCCTCTGCCCGGCCGCCCCTACTGGGAAGTGAGGAGCCCCTCAGCCCGGCCAGCCACCCCGTCCGGGAGGGAGGCCGGGGGGGGTGGTCGGCCAGCCGCCCCGTCCGGGAGGGAGGTGGGGGGGTCAGCCCCCCGCCCGGCCGGCCGCCCTGTCCGGGAGGTGAGGGGCGCCTCTGCCCGGCCGCCCCTACTGGGAAGTGAGGACCCCTCTGCCCGGCCAGCCGCCCCGTCCGGGAGGGAGGTGGGGGGGTCAGCCCCCTGCCCGGCCAGCCGCCCTATCCAGGAGGTGAGGGGCGCCTCTGCCCGGCTGCCCCTAC...
GGCGCCTCTGCCCGGCCGCCCCTACTGGGAAGTGAGGAGCCCCTCAGCCCGGCCAGCCACCCCGTCCGGGAGGGAGGCCGGGGGGGGTGGTCGGCCAGCCGCCCCGTCCGGGAGGGAGGTGGGGGGGTCAGCCCCCCGCCCGGCCGGCCGCCCTGTCCGGGAGGTGAGGGGCGCCTCTGCCCGGCCGCCCCTACTGGGAAGTGAGGACCCCTCTGCCCGGCCAGCCGCCCCGTCCGGGAGGGAGGTGGGGGGGTCAGCCCCCTGCCCGGCCAGCCGCCCTATCCAGGAGGTGAGGGGCGCCTCTGCCCGGCTGCCCCTAC...
pathogenic
7,389
Classify the chromosome 1 variant at position 42758864 affecting gene P3H1 (prolyl 3-hydroxylase 1) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Osteogenesis_imperfecta_type_8']
AAGCCACTGCACAAGTTACTTCATCTCTCAGATGCTAACAGTCCTCATCCCTAAAGTGGGAAGAAGAGTGCCAACCTTGCAGGGTGGCTGTGATGATTAAATGAGATGATGGATACAGCCCACCCCGCACAGAGCTTCGCCTGGACAGCGGCTCAACAAATGTTAGTTGCCTTCTTTCCAAAAGGGGACTTCTAGTTAAAAATGCTAGATTGGCCACGTGGGTTTATTTCCCCTCACTCCCCTCAGACTCCCCTTAATGGCCATAAGGAAGGCAGGGAAAAGGTATTAACCAAACAAGACAAAAGAGACCGGAAGTGCCA...
AAGCCACTGCACAAGTTACTTCATCTCTCAGATGCTAACAGTCCTCATCCCTAAAGTGGGAAGAAGAGTGCCAACCTTGCAGGGTGGCTGTGATGATTAAATGAGATGATGGATACAGCCCACCCCGCACAGAGCTTCGCCTGGACAGCGGCTCAACAAATGTTAGTTGCCTTCTTTCCAAAAGGGGACTTCTAGTTAAAAATGCTAGATTGGCCACGTGGGTTTATTTCCCCTCACTCCCCTCAGACTCCCCTTAATGGCCATAAGGAAGGCAGGGAAAAGGTATTAACCAAACAAGACAAAAGAGACCGGAAGTGCCA...
pathogenic
7,407
Determine if the mutation at chromosome 1, position 42758875 in gene P3H1 (prolyl 3-hydroxylase 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Osteogenesis_imperfecta_type_8']
CAAGTTACTTCATCTCTCAGATGCTAACAGTCCTCATCCCTAAAGTGGGAAGAAGAGTGCCAACCTTGCAGGGTGGCTGTGATGATTAAATGAGATGATGGATACAGCCCACCCCGCACAGAGCTTCGCCTGGACAGCGGCTCAACAAATGTTAGTTGCCTTCTTTCCAAAAGGGGACTTCTAGTTAAAAATGCTAGATTGGCCACGTGGGTTTATTTCCCCTCACTCCCCTCAGACTCCCCTTAATGGCCATAAGGAAGGCAGGGAAAAGGTATTAACCAAACAAGACAAAAGAGACCGGAAGTGCCATCTTAAAGCCA...
CAAGTTACTTCATCTCTCAGATGCTAACAGTCCTCATCCCTAAAGTGGGAAGAAGAGTGCCAACCTTGCAGGGTGGCTGTGATGATTAAATGAGATGATGGATACAGCCCACCCCGCACAGAGCTTCGCCTGGACAGCGGCTCAACAAATGTTAGTTGCCTTCTTTCCAAAAGGGGACTTCTAGTTAAAAATGCTAGATTGGCCACGTGGGTTTATTTCCCCTCACTCCCCTCAGACTCCCCTTAATGGCCATAAGGAAGGCAGGGAAAAGGTATTAACCAAACAAGACAAAAGAGACCGGAAGTGCCATCTTAAAGCCA...
pathogenic
7,408
Mutation found at chromosome 1 position 42762368, gene P3H1 (prolyl 3-hydroxylase 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Osteogenesis_imperfecta_type_8']
CAAATAAACACAACTTACTTTTTGTTTTGTTTTGTTTTGAGACAGAGTTTTTTTTTGAGACAGACAGCCCAGGCTGGAGGGCAGTGGCATGATCTCAGCTCACTGTAACCTCCACCTCCTGGGTTCAAGTGATTCTAGCGCCTCAGCCTCCTGAGAAGCTGGGATTACAGACATACACCACCACACCTGGTTAATTTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTTCTGGCCTCAAGTGATCCACTCACCTCGGCCTCCCAAAATTCTGGGATTACAGGCATGAGCCACCACG...
CAAATAAACACAACTTACTTTTTGTTTTGTTTTGTTTTGAGACAGAGTTTTTTTTTGAGACAGACAGCCCAGGCTGGAGGGCAGTGGCATGATCTCAGCTCACTGTAACCTCCACCTCCTGGGTTCAAGTGATTCTAGCGCCTCAGCCTCCTGAGAAGCTGGGATTACAGACATACACCACCACACCTGGTTAATTTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTTCTGGCCTCAAGTGATCCACTCACCTCGGCCTCCCAAAATTCTGGGATTACAGGCATGAGCCACCACG...
pathogenic
7,418
A genetic variant at chromosome 1, position 42766739, affecting gene P3H1—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Osteogenesis_imperfecta_type_8']
TGCTAAGAAAACTTATTTTCTTATCATTGGTACTAGTAAAGGCACACTAAAGGAGTCAGCCCTGGTTAGGTGACCCAAGGTAAATAACTCCCCATCTCTGTACCTCAGTTTCTTTAACTGTAAAATTAGAAATTTTTTCAGGTCTGTCCCTTTCATGGAATTACTCTAGCTCTTGTGTCTTTCAGCGCTGCTCCTGCCTTTCTCTGTTCTCCCTCATGTCCTCACTCCTCTCTCCACCCCCAGCCTTCTTTACTCTCTAAGCACTGAGGTACTTAACCTCCTCTCTTGTGGACAAATGTCTGCCTCCTAATCAAGTGCCA...
TGCTAAGAAAACTTATTTTCTTATCATTGGTACTAGTAAAGGCACACTAAAGGAGTCAGCCCTGGTTAGGTGACCCAAGGTAAATAACTCCCCATCTCTGTACCTCAGTTTCTTTAACTGTAAAATTAGAAATTTTTTCAGGTCTGTCCCTTTCATGGAATTACTCTAGCTCTTGTGTCTTTCAGCGCTGCTCCTGCCTTTCTCTGTTCTCCCTCATGTCCTCACTCCTCTCTCCACCCCCAGCCTTCTTTACTCTCTAAGCACTGAGGTACTTAACCTCCTCTCTTGTGGACAAATGTCTGCCTCCTAATCAAGTGCCA...
pathogenic
7,425
The genetic variant at chromosome 1, position 42766851, affecting gene P3H1 (prolyl 3-hydroxylase 1): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Osteogenesis_imperfecta_type_8']
TTTAACTGTAAAATTAGAAATTTTTTCAGGTCTGTCCCTTTCATGGAATTACTCTAGCTCTTGTGTCTTTCAGCGCTGCTCCTGCCTTTCTCTGTTCTCCCTCATGTCCTCACTCCTCTCTCCACCCCCAGCCTTCTTTACTCTCTAAGCACTGAGGTACTTAACCTCCTCTCTTGTGGACAAATGTCTGCCTCCTAATCAAGTGCCACCACTTTCTCCTTCTTCCAAGGCTCATTCACCATGGCTTCCAGAATAAGCGTTTTAAAACCCAAATCTGAGGATGGCTCCCTGCAGTCCGCAGAATTCTCTTCCAAATCTGG...
TTTAACTGTAAAATTAGAAATTTTTTCAGGTCTGTCCCTTTCATGGAATTACTCTAGCTCTTGTGTCTTTCAGCGCTGCTCCTGCCTTTCTCTGTTCTCCCTCATGTCCTCACTCCTCTCTCCACCCCCAGCCTTCTTTACTCTCTAAGCACTGAGGTACTTAACCTCCTCTCTTGTGGACAAATGTCTGCCTCCTAATCAAGTGCCACCACTTTCTCCTTCTTCCAAGGCTCATTCACCATGGCTTCCAGAATAAGCGTTTTAAAACCCAAATCTGAGGATGGCTCCCTGCAGTCCGCAGAATTCTCTTCCAAATCTGG...
pathogenic
7,426
Determine whether the variant at chromosome 1, position 42927211, in gene SLC2A1 (solute carrier family 2 member 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Encephalopathy_due_to_GLUT1_deficiency', 'Hereditary_cryohydrocytosis_with_reduced_stomatin', 'Inborn_genetic_diseases']
TCGCAACCTGCTCTTCTTTGTTGAGATGCAGATGGATGTCCTCATAGATTCTTTATACCTAATGGTAATACATATAGGTATTTCCATTTGCTAAGTACCAGTTTTCCTTTCTCACACCCTTCTTACAACCCCTCTTCATGTCAGGGAGAAAAAAGCCTGCCTGTAGTTACAAAAGCAAACTTCTCCCAGATTTTGTCAGCTGAGCCTCTAGAGACAAATATCTTTGGTGTTTTATTTCCTCCAGTATTTTCTGAGTGCCTGCTGTGCATCAAGCACTGTACTGAATAGTGCTGAGGACCCACAGGAACCAAATCGGCATC...
TCGCAACCTGCTCTTCTTTGTTGAGATGCAGATGGATGTCCTCATAGATTCTTTATACCTAATGGTAATACATATAGGTATTTCCATTTGCTAAGTACCAGTTTTCCTTTCTCACACCCTTCTTACAACCCCTCTTCATGTCAGGGAGAAAAAAGCCTGCCTGTAGTTACAAAAGCAAACTTCTCCCAGATTTTGTCAGCTGAGCCTCTAGAGACAAATATCTTTGGTGTTTTATTTCCTCCAGTATTTTCTGAGTGCCTGCTGTGCATCAAGCACTGTACTGAATAGTGCTGAGGACCCACAGGAACCAAATCGGCATC...
pathogenic
7,447
Is the genetic mutation found on chromosome 1 at position 42927574, within the gene SLC2A1 (solute carrier family 2 member 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
TGAAGGAGCAGATGAAGTGCTCTGGAAATTCAGGGGTGAAGGAGGAGGATGAGCTGTCTTTAGAGATGAAGCAGTAGTATACAGAGGAACCAGAGGGGGCAATTCCAAATGAAATGAACACAGGGCAGCTTGACAGCTCATTGGGCCCATACAAAGAACGTGGTTCATTTTGTGTGTGTGGGGAGGGGTGCAGGAGGTGGGTGGAGTTAATGGAGTAGTGGTTGTATGGTACCATTGTTAAAAGCAGGTGTTTTAGCTTATTCACTGTGCGACTTCAGGCACATAACCTCTTTGAGCCTGTCCAATAAAGGTACAGTATT...
TGAAGGAGCAGATGAAGTGCTCTGGAAATTCAGGGGTGAAGGAGGAGGATGAGCTGTCTTTAGAGATGAAGCAGTAGTATACAGAGGAACCAGAGGGGGCAATTCCAAATGAAATGAACACAGGGCAGCTTGACAGCTCATTGGGCCCATACAAAGAACGTGGTTCATTTTGTGTGTGTGGGGAGGGGTGCAGGAGGTGGGTGGAGTTAATGGAGTAGTGGTTGTATGGTACCATTGTTAAAAGCAGGTGTTTTAGCTTATTCACTGTGCGACTTCAGGCACATAACCTCTTTGAGCCTGTCCAATAAAGGTACAGTATT...
benign
7,452
A mutation at chromosome position 42927592 on chromosome 1 in gene SLC2A1 (solute carrier family 2 member 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
GCTCTGGAAATTCAGGGGTGAAGGAGGAGGATGAGCTGTCTTTAGAGATGAAGCAGTAGTATACAGAGGAACCAGAGGGGGCAATTCCAAATGAAATGAACACAGGGCAGCTTGACAGCTCATTGGGCCCATACAAAGAACGTGGTTCATTTTGTGTGTGTGGGGAGGGGTGCAGGAGGTGGGTGGAGTTAATGGAGTAGTGGTTGTATGGTACCATTGTTAAAAGCAGGTGTTTTAGCTTATTCACTGTGCGACTTCAGGCACATAACCTCTTTGAGCCTGTCCAATAAAGGTACAGTATTTACTTCACATTCAAAATA...
GCTCTGGAAATTCAGGGGTGAAGGAGGAGGATGAGCTGTCTTTAGAGATGAAGCAGTAGTATACAGAGGAACCAGAGGGGGCAATTCCAAATGAAATGAACACAGGGCAGCTTGACAGCTCATTGGGCCCATACAAAGAACGTGGTTCATTTTGTGTGTGTGGGGAGGGGTGCAGGAGGTGGGTGGAGTTAATGGAGTAGTGGTTGTATGGTACCATTGTTAAAAGCAGGTGTTTTAGCTTATTCACTGTGCGACTTCAGGCACATAACCTCTTTGAGCCTGTCCAATAAAGGTACAGTATTTACTTCACATTCAAAATA...
benign
7,453
Regarding the variant found on chromosome 1 at position 42929242 in gene SLC2A1 (solute carrier family 2 member 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Encephalopathy_due_to_GLUT1_deficiency', 'GLUT1_deficiency_syndrome_1,_autosomal_recessive']
AACCAGGAGCACAGTGAAGATGATGAAGACGTAGGGACCACACAGTTGCTGAAAGACACACAGACACACTTGGTTGGAGTCATGACCCTACATCCTGGCTGTAGGACTTTGGATAAGTCACTTTACCTTTGGGCCTTTGAGCTGAAAAGGGAACATCCACCTACCCAGGGATGCTATCATAATTAACTGAGACCACGCTTGTACCTAGAATGTAACAGGCTCCAGGAGCACCATTCAAGGCTAAGGGGAGAACCCTGGAGTTGAGGTCAGCATTCTTGGTCATGTGACCTGGGCTTCCTACCCTCAGTTTCCTCCTCAGC...
AACCAGGAGCACAGTGAAGATGATGAAGACGTAGGGACCACACAGTTGCTGAAAGACACACAGACACACTTGGTTGGAGTCATGACCCTACATCCTGGCTGTAGGACTTTGGATAAGTCACTTTACCTTTGGGCCTTTGAGCTGAAAAGGGAACATCCACCTACCCAGGGATGCTATCATAATTAACTGAGACCACGCTTGTACCTAGAATGTAACAGGCTCCAGGAGCACCATTCAAGGCTAAGGGGAGAACCCTGGAGTTGAGGTCAGCATTCTTGGTCATGTGACCTGGGCTTCCTACCCTCAGTTTCCTCCTCAGC...
pathogenic
7,488
Variant on chromosome 1, at position 42929605, affecting SLC2A1 (solute carrier family 2 member 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Childhood_onset_GLUT1_deficiency_syndrome_2', 'Encephalopathy_due_to_GLUT1_deficiency', 'GLUT1_deficiency_syndrome_1,_autosomal_recessive']
TGTGGGGTCATGCGTGCGGGTGAGTATAGAGACAGTGGGGGTTCTCACCTCCACATACTGGAAGCACATGCCCACAATGAAATTTGAGGTCCAGTTGGAGAAGCCTGCAACGGCAATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAG...
TGTGGGGTCATGCGTGCGGGTGAGTATAGAGACAGTGGGGGTTCTCACCTCCACATACTGGAAGCACATGCCCACAATGAAATTTGAGGTCCAGTTGGAGAAGCCTGCAACGGCAATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAG...
pathogenic
7,497
Gene mutation in SLC2A1 (solute carrier family 2 member 1) at chromosome 1, position 42929716—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Childhood_onset_GLUT1_deficiency_syndrome_2', 'Encephalopathy_due_to_GLUT1_deficiency']
GGCAATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATT...
GGCAATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATT...
pathogenic
7,510
For chromosome 1, position 42929719, gene SLC2A1 (solute carrier family 2 member 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Encephalopathy_due_to_GLUT1_deficiency', 'GLUT1_deficiency_syndrome_1,_autosomal_recessive']
AATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATTTAA...
AATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATTTAA...
pathogenic
7,511
Mutation at chromosome 1, position 42929720, within SLC2A1 (solute carrier family 2 member 1): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Childhood_onset_GLUT1_deficiency_syndrome_2', 'Encephalopathy_due_to_GLUT1_deficiency', 'GLUT1_deficiency_syndrome_1,_autosomal_recessive', 'Global_developmental_delay', 'Seizure', 'Strabismus']
ATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATTTAAG...
ATGGCAGCTGGACGTGGACCCTGGCTGAAGAGTTCAGCCACGATGAACCATGGGATGGGGCCAGGACCCACTTCAAAGAAGGCCACAAAGCCAAAGATGGCCACGATGCTCAGATAGGACATCCAGGGTAGCTGCTCCTGTTGAGGATGACGGAGAGGGGGAAAAGTTAGACTGGGTTGTGATGGATCCTCAGGGGAAACAGAAGCTACAGAGGCCAGAGCAGAGCTATGCGAGAAGGCAGGAAGCCTGGGGATGGTCCTGGATTTGTTGTGTATCCAGCATTGGGCCTAAGTTTCCTCATCCGAACAAAATGATTTAAG...
pathogenic
7,512