question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Chromosome 19, position 54122500, gene PRPF31: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Retinal_dystrophy']
CGCTGCCTGAGTCTTAAGGACTTAAAGAGCCATTTGAGCATCAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGC...
CGCTGCCTGAGTCTTAAGGACTTAAAGAGCCATTTGAGCATCAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGC...
pathogenic
309,819
Does the genetic variant at chromosome 19, position 54122530, impacting gene PRPF31, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic
CATTTGAGCATCAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGCTAATTTTTTTTCTTTAATTATGTGTAGAGA...
CATTTGAGCATCAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGCTAATTTTTTTTCTTTAATTATGTGTAGAGA...
pathogenic
309,820
Is the genetic mutation found on chromosome 19 at position 54122541, within the gene PRPF31, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Retinitis_pigmentosa']
CAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGCTAATTTTTTTTCTTTAATTATGTGTAGAGATGGGGTCTCCC...
CAGGGTTAGGAGTGCAGACTCTGACGCCGCCCTGCCTGGTGTCAGATCTGAGCTCTGCCTTCTACTGGCTGTGACATCAGGCAGTTAGTATTTGCATGACTTTTAAACACAACATCTTTTTGTTTGTTTGTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCCAGAATGCAGTGGCACGATCCCAGCTCACTGCAGCCTTGACCTTGTGGGCTCAGGCGTTCCTGCCTCAGCCTCCCAGGCAGCTGGGACCACAGGTGTACACCACCATGCCTGGCTAATTTTTTTTCTTTAATTATGTGTAGAGATGGGGTCTCCC...
pathogenic
309,821
Variant at chromosome 19, position 54123702, gene PRPF31 (pre-mRNA processing factor 31): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Retinal_dystrophy', 'Retinitis_pigmentosa_11']
TCAAGTCTAGACTGGTGTGGAGGGAGAGGGATTGAAGGCAGGAACACAAGTTCAGGGATGTCTGCAGACATCAGCCTGTCCCTGGTTTACTCTTCAGCCCCTCCTTCCTGACCCCTCCCAACTTCATCCTCCGCCTCCTCCAGCTGCGGGACCCGAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCC...
TCAAGTCTAGACTGGTGTGGAGGGAGAGGGATTGAAGGCAGGAACACAAGTTCAGGGATGTCTGCAGACATCAGCCTGTCCCTGGTTTACTCTTCAGCCCCTCCTTCCTGACCCCTCCCAACTTCATCCTCCGCCTCCTCCAGCTGCGGGACCCGAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCC...
pathogenic
309,831
Does the chromosome 19 mutation at position 54123800 within gene PRPF31 (pre-mRNA processing factor 31) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Retinitis_pigmentosa']
CCCTCCTTCCTGACCCCTCCCAACTTCATCCTCCGCCTCCTCCAGCTGCGGGACCCGAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCCCCGTGTGACGTCCCTCACGCCCCCTCTCCCTTCCCCACTGGCCTTTCCCAGGGTCCTGCCCCTAAGCCCAAGCTCAGATCGAGGTTGACCTGCTGTCA...
CCCTCCTTCCTGACCCCTCCCAACTTCATCCTCCGCCTCCTCCAGCTGCGGGACCCGAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCCCCGTGTGACGTCCCTCACGCCCCCTCTCCCTTCCCCACTGGCCTTTCCCAGGGTCCTGCCCCTAAGCCCAAGCTCAGATCGAGGTTGACCTGCTGTCA...
pathogenic
309,835
Variant at chromosome 19, position 54123856, gene PRPF31 (pre-mRNA processing factor 31): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Retinal_dystrophy']
GAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCCCCGTGTGACGTCCCTCACGCCCCCTCTCCCTTCCCCACTGGCCTTTCCCAGGGTCCTGCCCCTAAGCCCAAGCTCAGATCGAGGTTGACCTGCTGTCACAGAGTGGCTGAAATAAGAAGGAAGTGCGTTCTCTCGCGTATGAGTCTGAGGAGCA...
GAGAGGGGGTAGGGATTTAGATACTCACACCCATGCCTCCGTGTCCTCACAGTGATGGGACCAGTGGAGGCCGCGCCTGAATACCGCGTCATCGTGGATGCCAACAACCTGACCGTGGAGATCGAAAACGAGCTGAGTGAGTGCTGGGGGGCAGGCGGAGACAGCCCCGTGTGACGTCCCTCACGCCCCCTCTCCCTTCCCCACTGGCCTTTCCCAGGGTCCTGCCCCTAAGCCCAAGCTCAGATCGAGGTTGACCTGCTGTCACAGAGTGGCTGAAATAAGAAGGAAGTGCGTTCTCTCGCGTATGAGTCTGAGGAGCA...
pathogenic
309,836
Clinical impact (benign or pathogenic) of the variant at chromosome 19, location 54124556, gene PRPF31 (pre-mRNA processing factor 31): what disease(s) if pathogenic?
pathogenic
AAGTTCATCCGGGATAAGTACTCAAAGAGATTCCCTGAACTGGAGTCCTTGGTCCCCAATGCACTGGATTACATCCGCACGGTCAAGGTGAGCGCAGAGAAGGTGGGGTGCTTCTGCTGGCGTGAAGGGGCAGGCGGGGCTCACTCTCGGACCCCCTCCCAGAGGCCTGAGGGTCTGGAGACGATGGAGAGGAGTGGACGAGGGCTCAGTGGTCTGCTCTGCCCAGCGTGGGAGGGACGGAGCCTGGACAGGACTTTCTCAGGGCTCCCCTCCAACCCCAGTCTCCCGAGAGGGCTTCCCCGCTGGCCTGACCCACGCTG...
AAGTTCATCCGGGATAAGTACTCAAAGAGATTCCCTGAACTGGAGTCCTTGGTCCCCAATGCACTGGATTACATCCGCACGGTCAAGGTGAGCGCAGAGAAGGTGGGGTGCTTCTGCTGGCGTGAAGGGGCAGGCGGGGCTCACTCTCGGACCCCCTCCCAGAGGCCTGAGGGTCTGGAGACGATGGAGAGGAGTGGACGAGGGCTCAGTGGTCTGCTCTGCCCAGCGTGGGAGGGACGGAGCCTGGACAGGACTTTCTCAGGGCTCCCCTCCAACCCCAGTCTCCCGAGAGGGCTTCCCCGCTGGCCTGACCCACGCTG...
pathogenic
309,840
Is the genetic mutation found on chromosome 19 at position 54126537, within the gene PRPF31 (pre-mRNA processing factor 31), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Retinitis_pigmentosa_11']
CCCACCGCAGGTGTGGCCGGCGGCCTGACCAACCTCTCCAAGATGCCCGCCTGCAACATCATGCTGCTCGGGGCCCAGCGCAAGACGCTGTCGGGCTTCTCGTCTACCTCAGTGCTGCCCCACACCGGCTACATCTACCACAGTGACATCGTGCAGTCCCTGCCACCGGTGAGCCCACTGCGTCATGGCCCCTCCCCCGGCCCCCCTGGAGCCTTCCGCTGTGCCCAGACAGCCTGAGCAGCCACCCACCATCTGGCCCAGCTGACGGTAGCACTCAGGAGCTGGGAACAGGGTGGCATGGGACGTGAGAGCCAGGGCTC...
CCCACCGCAGGTGTGGCCGGCGGCCTGACCAACCTCTCCAAGATGCCCGCCTGCAACATCATGCTGCTCGGGGCCCAGCGCAAGACGCTGTCGGGCTTCTCGTCTACCTCAGTGCTGCCCCACACCGGCTACATCTACCACAGTGACATCGTGCAGTCCCTGCCACCGGTGAGCCCACTGCGTCATGGCCCCTCCCCCGGCCCCCCTGGAGCCTTCCGCTGTGCCCAGACAGCCTGAGCAGCCACCCACCATCTGGCCCAGCTGACGGTAGCACTCAGGAGCTGGGAACAGGGTGGCATGGGACGTGAGAGCCAGGGCTC...
pathogenic
309,845
Does the variant on chromosome 19 at location 54126574 affecting gene PRPF31 have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Retinitis_pigmentosa_11']
CCAAGATGCCCGCCTGCAACATCATGCTGCTCGGGGCCCAGCGCAAGACGCTGTCGGGCTTCTCGTCTACCTCAGTGCTGCCCCACACCGGCTACATCTACCACAGTGACATCGTGCAGTCCCTGCCACCGGTGAGCCCACTGCGTCATGGCCCCTCCCCCGGCCCCCCTGGAGCCTTCCGCTGTGCCCAGACAGCCTGAGCAGCCACCCACCATCTGGCCCAGCTGACGGTAGCACTCAGGAGCTGGGAACAGGGTGGCATGGGACGTGAGAGCCAGGGCTCTGCAGCAGACCAGCTCCAGCACCCACCAGTCAGGTGA...
CCAAGATGCCCGCCTGCAACATCATGCTGCTCGGGGCCCAGCGCAAGACGCTGTCGGGCTTCTCGTCTACCTCAGTGCTGCCCCACACCGGCTACATCTACCACAGTGACATCGTGCAGTCCCTGCCACCGGTGAGCCCACTGCGTCATGGCCCCTCCCCCGGCCCCCCTGGAGCCTTCCGCTGTGCCCAGACAGCCTGAGCAGCCACCCACCATCTGGCCCAGCTGACGGTAGCACTCAGGAGCTGGGAACAGGGTGGCATGGGACGTGAGAGCCAGGGCTCTGCAGCAGACCAGCTCCAGCACCCACCAGTCAGGTGA...
pathogenic
309,847
Clinical impact (benign or pathogenic) of the variant at chromosome 19, location 54128074, gene PRPF31 (pre-mRNA processing factor 31): what disease(s) if pathogenic?
pathogenic; ['Retinitis_pigmentosa']
TCGCTTCACTGTGGCTGACAGCTGGGCTCTGTTTGCAGTTTGGATTGGAACCCTGGCTCCATCACCTGCTGGCTGTCTCCCTGGCCACATGACTTGAAGCCTTGGTTTCCACATCTGAAAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCC...
TCGCTTCACTGTGGCTGACAGCTGGGCTCTGTTTGCAGTTTGGATTGGAACCCTGGCTCCATCACCTGCTGGCTGTCTCCCTGGCCACATGACTTGAAGCCTTGGTTTCCACATCTGAAAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCC...
pathogenic
309,851
Chromosome 19, position 54128166, gene PRPF31 (pre-mRNA processing factor 31): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Retinal_dystrophy']
CTTGAAGCCTTGGTTTCCACATCTGAAAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTA...
CTTGAAGCCTTGGTTTCCACATCTGAAAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTA...
pathogenic
309,854
Clinical impact (benign or pathogenic) of the variant at chromosome 19, location 54128192, gene PRPF31 (pre-mRNA processing factor 31): what disease(s) if pathogenic?
pathogenic; ['Retinal_dystrophy', 'Retinitis_pigmentosa']
AAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTT...
AAAGGGGGTGCAATGATCACACCAGCCCGATATTTGAATATTTGATGAGATGATCCGAGGGGCGTGCTTAGCATGGGGCTGGCATCCAGGCCGAGTGCACTCCCCCCGGCGTCTCCACAGTCACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTT...
pathogenic
309,857
Clinical classification of chromosome 19, position 54128314, gene PRPF31 (pre-mRNA processing factor 31): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Retinal_dystrophy']
ACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTTGCTTTGCTGTTACCTCTGTCTGTCTGTCTCACACAGATTCCACCCCCGTTTTCCGTTGCTCCAGGATCTGCGGCGGAAAGCGGCCCGGCTGGTGGCCGCCAAGTGCACACTGGCAGCCCGTG...
ACCACCGTCCTCGTTGTCAGCGTGCCTTACTGTCATCCTTACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTTGCTTTGCTGTTACCTCTGTCTGTCTGTCTCACACAGATTCCACCCCCGTTTTCCGTTGCTCCAGGATCTGCGGCGGAAAGCGGCCCGGCTGGTGGCCGCCAAGTGCACACTGGCAGCCCGTG...
pathogenic
309,862
A genetic variant on chromosome 19, position 54128354, affects the gene PRPF31 (pre-mRNA processing factor 31). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Retinal_dystrophy']
ACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTTGCTTTGCTGTTACCTCTGTCTGTCTGTCTCACACAGATTCCACCCCCGTTTTCCGTTGCTCCAGGATCTGCGGCGGAAAGCGGCCCGGCTGGTGGCCGCCAAGTGCACACTGGCAGCCCGTGTGGACAGTTTCCACGAGAGCACAGAAGGGAAGGTGAGGAG...
ACCTGATGGCCACTTATCAGCTGGGACATGGCTCTGTGCCCTGCCCTCATCCCCTCTTCCTGTGAAGTAGGAGCTGAGAGCACACACCTCTAGAGCCCAAGGGTGGAAAGCCCCCTTCCAGGACCCCAGGTAGAGCCAGAGGAGGAGCGCGCGCGGTTGCTTTGCTGTTACCTCTGTCTGTCTGTCTCACACAGATTCCACCCCCGTTTTCCGTTGCTCCAGGATCTGCGGCGGAAAGCGGCCCGGCTGGTGGCCGCCAAGTGCACACTGGCAGCCCGTGTGGACAGTTTCCACGAGAGCACAGAAGGGAAGGTGAGGAG...
pathogenic
309,865
Gene PRPF31 (pre-mRNA processing factor 31) variant at chromosome position 54129137 on chromosome 19: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Retinal_dystrophy']
CAGCTTGGGTGACATAGCGAGACTCCATCTAAAAACAAAAACAAAAAACAGTACAGGTTTATTATCTGTGGTCCTGTAGGTCAGAAGTCCAAAATGAGTTTCACTGGGCTGAAGTCAGGGTGTCATCCTGGAGCGTTCCTTCTGGGGGATTCAAGGGATAATCCATTCCCTGGTCTTTTCCAGCTTCTAGGGGTCACTGGCACCCCTTAGCTCGTGGCCCTCCCTCTGTCTGCGGAGCCAGCCACATAGCACCCTCAGACCTCTCTCTGACTCTGCTTCTGTCTTCATATCTCCGCCTCTGTTTTTGTTCCCCTCTTCTA...
CAGCTTGGGTGACATAGCGAGACTCCATCTAAAAACAAAAACAAAAAACAGTACAGGTTTATTATCTGTGGTCCTGTAGGTCAGAAGTCCAAAATGAGTTTCACTGGGCTGAAGTCAGGGTGTCATCCTGGAGCGTTCCTTCTGGGGGATTCAAGGGATAATCCATTCCCTGGTCTTTTCCAGCTTCTAGGGGTCACTGGCACCCCTTAGCTCGTGGCCCTCCCTCTGTCTGCGGAGCCAGCCACATAGCACCCTCAGACCTCTCTCTGACTCTGCTTCTGTCTTCATATCTCCGCCTCTGTTTTTGTTCCCCTCTTCTA...
pathogenic
309,871
A genetic variant at chromosome 19, position 54146018, affecting gene CNOT3 (CCR4-NOT transcription complex subunit 3)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Intellectual_developmental_disorder_with_speech_delay,_autism,_and_dysmorphic_facies']
CTTTGAGAGCCCCCCTGCCAACTGCACTCTCTACAGCAAATGGAACGGTTCAAAGTTGTGGAACGAGAGACCAAAACCAAAGCTTACAGCAAAGAGGGCCTGGGCCTGGCCCAGAAGGTAGATCCTGCCCAGAAGGAGAAGGAAGAGGTTGGCCAGTGGCTCACGGTGAGTTGGGGTAGAGAAGAGGAGGTGAACTCTGAGGATCCTGAGCCCTGGGTGTAGGCGGAACCCTAGCTGATGGGCTTCCTCTTCCTCTCCCTCCCCTAGAATACCATCGACACGCTCAACATGCAGGTGGACCAGTTTGAGAGTGAAGTGGA...
CTTTGAGAGCCCCCCTGCCAACTGCACTCTCTACAGCAAATGGAACGGTTCAAAGTTGTGGAACGAGAGACCAAAACCAAAGCTTACAGCAAAGAGGGCCTGGGCCTGGCCCAGAAGGTAGATCCTGCCCAGAAGGAGAAGGAAGAGGTTGGCCAGTGGCTCACGGTGAGTTGGGGTAGAGAAGAGGAGGTGAACTCTGAGGATCCTGAGCCCTGGGTGTAGGCGGAACCCTAGCTGATGGGCTTCCTCTTCCTCTCCCTCCCCTAGAATACCATCGACACGCTCAACATGCAGGTGGACCAGTTTGAGAGTGAAGTGGA...
pathogenic
309,892
Does the variant on chromosome 19 at location 54152897 affecting gene CNOT3 (CCR4-NOT transcription complex subunit 3) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; []
GGTGCAATCTCAGCTGAATGCAACATCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCGCAGCCTACTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCCAGGCTAATTTTTATATTTTTAATAGAGATGGGGTTTTGCCATGTTGGTCAGGCAGGTCTTGAACTCCGAACCTCAGGTGATCCACCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCCAAATTTTAGAAGTAGGTGGACAGGATATTTATAGTGCGTGCATTTTTCTGGAAAAAGGGAAACAGCAGCTTTGAGAT...
GGTGCAATCTCAGCTGAATGCAACATCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCGCAGCCTACTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCCAGGCTAATTTTTATATTTTTAATAGAGATGGGGTTTTGCCATGTTGGTCAGGCAGGTCTTGAACTCCGAACCTCAGGTGATCCACCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCCAAATTTTAGAAGTAGGTGGACAGGATATTTATAGTGCGTGCATTTTTCTGGAAAAAGGGAAACAGCAGCTTTGAGAT...
pathogenic
309,906
Variant chromosome 19, position 54152938, gene CNOT3 (CCR4-NOT transcription complex subunit 3): benign or pathogenic? Disease(s)?
pathogenic
AAGCGATTCTCCTGCCGCAGCCTACTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCCAGGCTAATTTTTATATTTTTAATAGAGATGGGGTTTTGCCATGTTGGTCAGGCAGGTCTTGAACTCCGAACCTCAGGTGATCCACCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCCAAATTTTAGAAGTAGGTGGACAGGATATTTATAGTGCGTGCATTTTTCTGGAAAAAGGGAAACAGCAGCTTTGAGATTTTCAGAAGGGGTCCATATCTTTTAACACCACCAACAACAA...
AAGCGATTCTCCTGCCGCAGCCTACTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCCAGGCTAATTTTTATATTTTTAATAGAGATGGGGTTTTGCCATGTTGGTCAGGCAGGTCTTGAACTCCGAACCTCAGGTGATCCACCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCCAAATTTTAGAAGTAGGTGGACAGGATATTTATAGTGCGTGCATTTTTCTGGAAAAAGGGAAACAGCAGCTTTGAGATTTTCAGAAGGGGTCCATATCTTTTAACACCACCAACAACAA...
pathogenic
309,908
Does the chromosome 19 mutation at position 54180848 within gene MBOAT7 (membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Inborn_genetic_diseases', 'Intellectual_disability,_autosomal_recessive_57']
GATATACTGCGCCAGCCACCACTGCACCGTCATGTTCCAGTACCGCATGCCATCGCGCACCCGCACGCAGAAATCTGTGCTGTAGCAGTCGATGTTGCGGATGGTCTCATAGTCATACTCCAAGGAAGCCGCCTTCTCCGGACTGGGGGGTGGAGGATGAGGGTGGGGGACAGACATGCAGCTCAGCCAGGCCCCCTCCCGACGCCTGCTAGTGTCCCAGCCCCGGATGCTAAGGAAGGGATCCTGGCCAGGCAATGGCCCTCTGGCTGTCAGACTTGCTAGGGCAGCAAGGGAGGGTGGCCCAGAGGGTGCCTGTAGGG...
GATATACTGCGCCAGCCACCACTGCACCGTCATGTTCCAGTACCGCATGCCATCGCGCACCCGCACGCAGAAATCTGTGCTGTAGCAGTCGATGTTGCGGATGGTCTCATAGTCATACTCCAAGGAAGCCGCCTTCTCCGGACTGGGGGGTGGAGGATGAGGGTGGGGGACAGACATGCAGCTCAGCCAGGCCCCCTCCCGACGCCTGCTAGTGTCCCAGCCCCGGATGCTAAGGAAGGGATCCTGGCCAGGCAATGGCCCTCTGGCTGTCAGACTTGCTAGGGCAGCAAGGGAGGGTGGCCCAGAGGGTGCCTGTAGGG...
pathogenic
309,914
Regarding the variant at chromosome 19 and position 54180936, affecting gene MBOAT7 (membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Intellectual_disability,_autosomal_recessive_57']
TCGATGTTGCGGATGGTCTCATAGTCATACTCCAAGGAAGCCGCCTTCTCCGGACTGGGGGGTGGAGGATGAGGGTGGGGGACAGACATGCAGCTCAGCCAGGCCCCCTCCCGACGCCTGCTAGTGTCCCAGCCCCGGATGCTAAGGAAGGGATCCTGGCCAGGCAATGGCCCTCTGGCTGTCAGACTTGCTAGGGCAGCAAGGGAGGGTGGCCCAGAGGGTGCCTGTAGGGTAGGAAGGTGGGTGGGCTGGGTGGTACAGTCCACTGACAATGGGGTTCTTCTTCTTTTGGTACCTAATGGGGCCCGCCACAGCCATGA...
TCGATGTTGCGGATGGTCTCATAGTCATACTCCAAGGAAGCCGCCTTCTCCGGACTGGGGGGTGGAGGATGAGGGTGGGGGACAGACATGCAGCTCAGCCAGGCCCCCTCCCGACGCCTGCTAGTGTCCCAGCCCCGGATGCTAAGGAAGGGATCCTGGCCAGGCAATGGCCCTCTGGCTGTCAGACTTGCTAGGGCAGCAAGGGAGGGTGGCCCAGAGGGTGCCTGTAGGGTAGGAAGGTGGGTGGGCTGGGTGGTACAGTCCACTGACAATGGGGTTCTTCTTCTTTTGGTACCTAATGGGGCCCGCCACAGCCATGA...
pathogenic
309,915
Evaluate if the mutation on chromosome 19 at position 55014735 in GP6 (glycoprotein VI platelet) is benign or pathogenic. Disease name(s) if pathogenic?
benign
CTGCATATCAACATTCAGTATCACATTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCGTGTGCCACCACGACTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCTGAGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCCACCTCAGCCTCCCGAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCGGCCAGTATCACATGTTTATACCCACAGATATTCGCAGC...
CTGCATATCAACATTCAGTATCACATTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGCGTGTGCCACCACGACTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCTGAGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCCACCTCAGCCTCCCGAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCGGCCAGTATCACATGTTTATACCCACAGATATTCGCAGC...
benign
310,010
A genetic alteration at chromosome 19, position 55133961, in gene TNNT1 (troponin T1, slow skeletal type)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
CCCAGCTACTCGGGAGGCTGAGGCAGAATTGCTTGAACCCGGGAGGTGGAGGTTGCGGTGAGCCGAGATCTTGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGCTGGGCATGGTGGCTCACACCTGTAATCCCACCACTTTGGGAGGCTGAGGCGGGAGGATCAGCTGAGGTCAGGAGTCTGAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGTTGGTGGGCACCTGTAGTCCCAGCTGCTTGGGAG...
CCCAGCTACTCGGGAGGCTGAGGCAGAATTGCTTGAACCCGGGAGGTGGAGGTTGCGGTGAGCCGAGATCTTGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGCTGGGCATGGTGGCTCACACCTGTAATCCCACCACTTTGGGAGGCTGAGGCGGGAGGATCAGCTGAGGTCAGGAGTCTGAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGTTGGTGGGCACCTGTAGTCCCAGCTGCTTGGGAG...
benign
310,064
Variant on chromosome 19, at position 55137107, affecting TNNT1 (troponin T1, slow skeletal type): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Nemaline_myopathy_5']
TCTTCTAGAAATAGCCTCTTGTGCATTAGGCTGAGTTGAAAAACTACTTTGCCCAATCTCCCTTGCAGGTAGGGGTGGCTACTCAGACGAAAGCAGGTCACTGGGTGCGGCTTCCAAAAGAGACTGTGTGGCTCTTCTCTTGCGTCTTCTTTCTGCTGCTTGGATCATCCATGTGAGGCTGGAGCTAGCAGCTATATTGGACTAAGTGATTTTGAGGATGGAAATATTGGGCTAAAAGTAGTGAGTGAAGCAGAAAACATAGGAGTCTGGTCTCTGATTTTGTAGAATTGCCATACCAGCCCTGGACTAAAACCTACCTT...
TCTTCTAGAAATAGCCTCTTGTGCATTAGGCTGAGTTGAAAAACTACTTTGCCCAATCTCCCTTGCAGGTAGGGGTGGCTACTCAGACGAAAGCAGGTCACTGGGTGCGGCTTCCAAAAGAGACTGTGTGGCTCTTCTCTTGCGTCTTCTTTCTGCTGCTTGGATCATCCATGTGAGGCTGGAGCTAGCAGCTATATTGGACTAAGTGATTTTGAGGATGGAAATATTGGGCTAAAAGTAGTGAGTGAAGCAGAAAACATAGGAGTCTGGTCTCTGATTTTGTAGAATTGCCATACCAGCCCTGGACTAAAACCTACCTT...
pathogenic
310,068
The chromosome 19, position 55154219 genetic variant in gene TNNI3 (troponin I3, cardiac type): benign or pathogenic? If pathogenic, indicate disease(s).
benign
TTCTGTCTTTCCCCATCCACTTCCTGTCTCCCTCATGCACTTCCTGTCTTTCCCCTCCACTTCCTGTCTCCTTCCTGCACTTCCTATCTTTCCCCTCCACTTCCTGTCTGCCTTATGCCCTTCCTGTCTCCTTCCTTCTCTTCTTATTATAGTAGTCCCTCCTTTTCTGCAATTTTACTTTGTGTGGTTTCAGTTACCTGAGGTAAACCATGGCCCAAAAATATTAAATGGAAAATTCCAGAAATAAACAATTCATAAGTTTGATGGATTCTCAGGTCAATAGTAGCCTAACGCCAGGTCATAATGCCTATGTCATCCAC...
TTCTGTCTTTCCCCATCCACTTCCTGTCTCCCTCATGCACTTCCTGTCTTTCCCCTCCACTTCCTGTCTCCTTCCTGCACTTCCTATCTTTCCCCTCCACTTCCTGTCTGCCTTATGCCCTTCCTGTCTCCTTCCTTCTCTTCTTATTATAGTAGTCCCTCCTTTTCTGCAATTTTACTTTGTGTGGTTTCAGTTACCTGAGGTAAACCATGGCCCAAAAATATTAAATGGAAAATTCCAGAAATAAACAATTCATAAGTTTGATGGATTCTCAGGTCAATAGTAGCCTAACGCCAGGTCATAATGCCTATGTCATCCAC...
benign
310,155
Variant at chromosome position 55156184, chromosome 19, gene TNNI3 (troponin I3, cardiac type): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
CTCACTCTCCGCAGGGTGGGCCGCTTAAACTTGCCTCGAAGGTCAAAGATCTTCTGAGTCAGATCTGCAATCTGGGGGCACACGAGGGGGTGGGTACTTCTCCTTCCATTTCCCGCACACCCAACTCCTCCATCCTACACTCCTTTTTTATTCTCCTTATCTCGTCTTCCAGTACCGAGGCCTTACCAGTCTCTTCCCGGCTTAGGCTCCCAGTCTAGGCTTCTAATCCTGGAACTGAATCCCCCTCCTCATATGCTCCAGCCTCACCTCTCAAAACCACTGGCATAACCTGGTCCAGCTACATGCAAATCACAATTCCC...
CTCACTCTCCGCAGGGTGGGCCGCTTAAACTTGCCTCGAAGGTCAAAGATCTTCTGAGTCAGATCTGCAATCTGGGGGCACACGAGGGGGTGGGTACTTCTCCTTCCATTTCCCGCACACCCAACTCCTCCATCCTACACTCCTTTTTTATTCTCCTTATCTCGTCTTCCAGTACCGAGGCCTTACCAGTCTCTTCCCGGCTTAGGCTCCCAGTCTAGGCTTCTAATCCTGGAACTGAATCCCCCTCCTCATATGCTCCAGCCTCACCTCTCAAAACCACTGGCATAACCTGGTCCAGCTACATGCAAATCACAATTCCC...
benign
310,172
Gene mutation in DNAAF3 at chromosome 19, position 55159416—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Primary_ciliary_dyskinesia', 'Primary_ciliary_dyskinesia_2']
GACCCCTGGAGTCCCCTCTGAACAAGAGGTCGGGGGACCGCGCTTCCCCTTCCTTGGGTTCCAGGAGTCTGACTCGCAAACCCACTTCCTCTCTTCACCCAAGAGTCCCTACGCCTACCTCGCAGGCCAAGGGTCCAGCCTCTCAGCTGCGACCCCTCTTGGGAACCCGGGAGGTCGCCCCCAACTCCCACTGCCTTGGGGCATCACTCACCCATCCGCCATGCTGAGACTCAGGCCGGGAATGGCAGGAGGCAGGGCGAGGACAGGGGCGTTTGGAGGGTCAGTGAGGGGGCCGCCCGGGTGACCTTCAGGGTCCCAGG...
GACCCCTGGAGTCCCCTCTGAACAAGAGGTCGGGGGACCGCGCTTCCCCTTCCTTGGGTTCCAGGAGTCTGACTCGCAAACCCACTTCCTCTCTTCACCCAAGAGTCCCTACGCCTACCTCGCAGGCCAAGGGTCCAGCCTCTCAGCTGCGACCCCTCTTGGGAACCCGGGAGGTCGCCCCCAACTCCCACTGCCTTGGGGCATCACTCACCCATCCGCCATGCTGAGACTCAGGCCGGGAATGGCAGGAGGCAGGGCGAGGACAGGGGCGTTTGGAGGGTCAGTGAGGGGGCCGCCCGGGTGACCTTCAGGGTCCCAGG...
pathogenic
310,227
A genetic variant at chromosome 19, position 55159575, affecting gene DNAAF3—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Primary_ciliary_dyskinesia', 'Primary_ciliary_dyskinesia_2']
TGGGAACCCGGGAGGTCGCCCCCAACTCCCACTGCCTTGGGGCATCACTCACCCATCCGCCATGCTGAGACTCAGGCCGGGAATGGCAGGAGGCAGGGCGAGGACAGGGGCGTTTGGAGGGTCAGTGAGGGGGCCGCCCGGGTGACCTTCAGGGTCCCAGGGACCGTCAGTCTCCTCCGGGCTGCTTGAGACTCCCCGAGGACACTGAGATAAAGGGCGAGGACACAGACTAAATATACTGTCACCTCCTCCTCCCCCTGCCCACTATGCCAGATAACGGGGGCGCGTGAGGGGCGGGGTGGGCCCTGCTCCAGCTGGAT...
TGGGAACCCGGGAGGTCGCCCCCAACTCCCACTGCCTTGGGGCATCACTCACCCATCCGCCATGCTGAGACTCAGGCCGGGAATGGCAGGAGGCAGGGCGAGGACAGGGGCGTTTGGAGGGTCAGTGAGGGGGCCGCCCGGGTGACCTTCAGGGTCCCAGGGACCGTCAGTCTCCTCCGGGCTGCTTGAGACTCCCCGAGGACACTGAGATAAAGGGCGAGGACACAGACTAAATATACTGTCACCTCCTCCTCCCCCTGCCCACTATGCCAGATAACGGGGGCGCGTGAGGGGCGGGGTGGGCCCTGCTCCAGCTGGAT...
pathogenic
310,230
A genetic alteration at chromosome 19, position 55160605, in gene DNAAF3—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
AAACCCAGGAATCTGGTTTCTGGCTTCCTCTGTCCAGCACTCCTGGGCCTTTCTCTCCCAGCCCTGGAGACGGACATAGGACAGGAAAGACGCTTGGACACACAGAAGGGTGGACACAACTTGCTTTACTTGAACCATCTGGGTGCTGACCAGGCCCTGGTGAGGAGACACCCCAGCCCCTAGTCAGCCACAGGGTGCCTGGGAACAAGGGGGCCAAAGTCAAGGGCCTGAGACTCAGTGTCAGATCCTAGGCTGGGCTTAGAGCCTCAGAAGTGGAATTTGGAATTCTGAGAGAACAATCTAGAATTCTAGGAATAGAC...
AAACCCAGGAATCTGGTTTCTGGCTTCCTCTGTCCAGCACTCCTGGGCCTTTCTCTCCCAGCCCTGGAGACGGACATAGGACAGGAAAGACGCTTGGACACACAGAAGGGTGGACACAACTTGCTTTACTTGAACCATCTGGGTGCTGACCAGGCCCTGGTGAGGAGACACCCCAGCCCCTAGTCAGCCACAGGGTGCCTGGGAACAAGGGGGCCAAAGTCAAGGGCCTGAGACTCAGTGTCAGATCCTAGGCTGGGCTTAGAGCCTCAGAAGTGGAATTTGGAATTCTGAGAGAACAATCTAGAATTCTAGGAATAGAC...
benign
310,235
The genetic variant at chromosome 19, position 55160690, affecting gene DNAAF3: benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Primary_ciliary_dyskinesia', 'Primary_ciliary_dyskinesia_2']
AAAGACGCTTGGACACACAGAAGGGTGGACACAACTTGCTTTACTTGAACCATCTGGGTGCTGACCAGGCCCTGGTGAGGAGACACCCCAGCCCCTAGTCAGCCACAGGGTGCCTGGGAACAAGGGGGCCAAAGTCAAGGGCCTGAGACTCAGTGTCAGATCCTAGGCTGGGCTTAGAGCCTCAGAAGTGGAATTTGGAATTCTGAGAGAACAATCTAGAATTCTAGGAATAGACCATAGAATCTCAGAAATGGAATTTGAAAGTCTACCAACACTCCCGGGGTGGGGGTGGCGGGTACTGAGTGGGAATGATTAGAATA...
AAAGACGCTTGGACACACAGAAGGGTGGACACAACTTGCTTTACTTGAACCATCTGGGTGCTGACCAGGCCCTGGTGAGGAGACACCCCAGCCCCTAGTCAGCCACAGGGTGCCTGGGAACAAGGGGGCCAAAGTCAAGGGCCTGAGACTCAGTGTCAGATCCTAGGCTGGGCTTAGAGCCTCAGAAGTGGAATTTGGAATTCTGAGAGAACAATCTAGAATTCTAGGAATAGACCATAGAATCTCAGAAATGGAATTTGAAAGTCTACCAACACTCCCGGGGTGGGGGTGGCGGGTACTGAGTGGGAATGATTAGAATA...
pathogenic
310,237
Considering the variant on chromosome 19, location 55161694, involving gene DNAAF3, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Primary_ciliary_dyskinesia', 'Primary_ciliary_dyskinesia_2']
AAATCCGGAGGGAGGATGGGGCTCTGGGATCCCAGACAATGAGGGAGGAGGGGTGGCAAAACTGGAGTCTGGGTCCTGGGGAAAGAAGGGAGCAGGAGGTCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACCCCTGGGTCTAAGCAAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGATCCTGGGTCTTTGTGAGCACAGCTGCCTCCCCGCTTACCCACAGGCCACATAGAGGAGCTGGAATCGGCCGTTGTAGCAGCTCTTGTGGTGGAGAGTCTGAGCAG...
AAATCCGGAGGGAGGATGGGGCTCTGGGATCCCAGACAATGAGGGAGGAGGGGTGGCAAAACTGGAGTCTGGGTCCTGGGGAAAGAAGGGAGCAGGAGGTCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACCCCTGGGTCTAAGCAAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGATCCTGGGTCTTTGTGAGCACAGCTGCCTCCCCGCTTACCCACAGGCCACATAGAGGAGCTGGAATCGGCCGTTGTAGCAGCTCTTGTGGTGGAGAGTCTGAGCAG...
pathogenic
310,261
A genetic variant on chromosome 19, position 55161747, affects the gene DNAAF3. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Primary_ciliary_dyskinesia', 'Primary_ciliary_dyskinesia_2']
TGGCAAAACTGGAGTCTGGGTCCTGGGGAAAGAAGGGAGCAGGAGGTCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACCCCTGGGTCTAAGCAAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGATCCTGGGTCTTTGTGAGCACAGCTGCCTCCCCGCTTACCCACAGGCCACATAGAGGAGCTGGAATCGGCCGTTGTAGCAGCTCTTGTGGTGGAGAGTCTGAGCAGAATTGAGCGGCAGGAAGTGGACGGTGAAAGATTCCGGGGTCGGGGCTGCTGGG...
TGGCAAAACTGGAGTCTGGGTCCTGGGGAAAGAAGGGAGCAGGAGGTCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACCCCTGGGTCTAAGCAAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGATCCTGGGTCTTTGTGAGCACAGCTGCCTCCCCGCTTACCCACAGGCCACATAGAGGAGCTGGAATCGGCCGTTGTAGCAGCTCTTGTGGTGGAGAGTCTGAGCAGAATTGAGCGGCAGGAAGTGGACGGTGAAAGATTCCGGGGTCGGGGCTGCTGGG...
pathogenic
310,262
Does the variant impacting AURKC (aurora kinase C) on chromosome 19, position 57232069, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Infertility_associated_with_multi-tailed_spermatozoa_and_excessive_DNA']
CTTTTTTGTTTTTGGGTTTTTTTGTTTTTGTTTTTGTTTTTTTTGAGACAGAGTCTCGTTCTCCTTCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTCAAGCGATTCTCTTGCCTCAGCCTTTTGAGTAGGTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTTGTAGTAGAAACGGGGTTTCGCCCTGTTGGCCAGGCTGGTCTCGAACTGCCTACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCACGC...
CTTTTTTGTTTTTGGGTTTTTTTGTTTTTGTTTTTGTTTTTTTTGAGACAGAGTCTCGTTCTCCTTCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTCAAGCGATTCTCTTGCCTCAGCCTTTTGAGTAGGTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTTGTAGTAGAAACGGGGTTTCGCCCTGTTGGCCAGGCTGGTCTCGAACTGCCTACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCACGC...
pathogenic
310,388
Is the variant located on chromosome 20 at position 417395, gene RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
GACAGAAGTGAGACCCTGTCTCAAAAAAAACAAAAACAAACAAAACCCCTCAATACTATTATCACACCTTAGAAAAGGAATAAGAATTCCTTAAAATCCGCTAATGCCCTGTTTATATTCACATTTTCCTATTTCATTAGTGCTTTTTACAATTGGTTTCTTCAAATCAGGAGCCAAACAAGATCTACATGTAGCATTTCTTACTATGTCTTAAGTCCCTTTTACTCTCCTCTATTTTTATGCCACTAGTTTTTTTTTTAAGAAACCTGGTCTTTTGACCTCTAGAATTTTCCCCATATTCTGGATCTATCCATTACCTC...
GACAGAAGTGAGACCCTGTCTCAAAAAAAACAAAAACAAACAAAACCCCTCAATACTATTATCACACCTTAGAAAAGGAATAAGAATTCCTTAAAATCCGCTAATGCCCTGTTTATATTCACATTTTCCTATTTCATTAGTGCTTTTTACAATTGGTTTCTTCAAATCAGGAGCCAAACAAGATCTACATGTAGCATTTCTTACTATGTCTTAAGTCCCTTTTACTCTCCTCTATTTTTATGCCACTAGTTTTTTTTTTAAGAAACCTGGTCTTTTGACCTCTAGAATTTTCCCCATATTCTGGATCTATCCATTACCTC...
benign
310,468
Considering the variant on chromosome 20, location 419860, involving gene RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
benign
GCACTCCCATGGGGTGCGGCAGAATGGGGACAGTGCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGAAGGTGAGGCTCTGCCCTGAGCACCGCCGGACCCAGCGGGGGCCCTGGACTCACTTGAGGGCATAGGGCAAGCAGGGGCAGAGCCCCTGGGTTTTTAGTCAGGGACTCACCCAGAGGACCCTATCCAAGTGGGGAAGAGAGGACCTAAGACACATGGGAGGGAGCATTTCAGGGACCCATCATGAGAACAGCTGGCACGGGGAG...
GCACTCCCATGGGGTGCGGCAGAATGGGGACAGTGCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGAAGGTGAGGCTCTGCCCTGAGCACCGCCGGACCCAGCGGGGGCCCTGGACTCACTTGAGGGCATAGGGCAAGCAGGGGCAGAGCCCCTGGGTTTTTAGTCAGGGACTCACCCAGAGGACCCTATCCAAGTGGGGAAGAGAGGACCTAAGACACATGGGAGGGAGCATTTCAGGGACCCATCATGAGAACAGCTGGCACGGGGAG...
benign
310,478
The mutation impacting CSNK2A1 (casein kinase 2 alpha 1) on chromosome 20 at position 499923: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Okur-Chung_neurodevelopmental_syndrome']
TTACCGTTGTTCCAAGATCTGTCCATTCACTGCCCTCTATTTCTCCAACATTACATTAACTTTAAAGAGATACTTTGGGTCTTCAACTCTTAAAAATGAAGAATTACTTAAACATATATTGCGGAAGCTATAATCCACTGTCAGAAACATACTGATCTAGATACGTTAATATGCACTGACACCCACCTATAATTTAGTTTGCTTTTCATGTATCTTCAGACCTTCTCAAAAGAGGCATTTTGGCAAATATACTGCCTCCTTAGTAGGGAACTAACTCATCTTTGCCTTACATAGTTGGCCCTGCAGATCACCAGTGGGTA...
TTACCGTTGTTCCAAGATCTGTCCATTCACTGCCCTCTATTTCTCCAACATTACATTAACTTTAAAGAGATACTTTGGGTCTTCAACTCTTAAAAATGAAGAATTACTTAAACATATATTGCGGAAGCTATAATCCACTGTCAGAAACATACTGATCTAGATACGTTAATATGCACTGACACCCACCTATAATTTAGTTTGCTTTTCATGTATCTTCAGACCTTCTCAAAAGAGGCATTTTGGCAAATATACTGCCTCCTTAGTAGGGAACTAACTCATCTTTGCCTTACATAGTTGGCCCTGCAGATCACCAGTGGGTA...
pathogenic
310,549
The genetic variant at chromosome 20, position 761009, affecting gene SLC52A3 (solute carrier family 52 member 3): benign or pathogenic? Disease name(s) if pathogenic?
benign
ATAAAAGTGCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAAGAGAAACTGGGCAGATGAGGGAGAGGAAAGGGATGAAAACCTTTCTCTGTACACCTTATATTTTCTGATTTTTTGAAACACGTGACTGTATTACCTATTCACAGTAAGTTAACAGGGATGGGAAGCATGGTGGTGGCAAGCAAACGAAACCTCTAAAAAGAAGTCCCAGGGGCCGGGCGCAGTGGCTAACTCTTATGATCTTAGCGCTTTGAGAGGCCAAGGTGGGCAGATTGCCTGAACTCAGGAGTTCGAGACCAGCCTGGGCAACATG...
ATAAAAGTGCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAAGAGAAACTGGGCAGATGAGGGAGAGGAAAGGGATGAAAACCTTTCTCTGTACACCTTATATTTTCTGATTTTTTGAAACACGTGACTGTATTACCTATTCACAGTAAGTTAACAGGGATGGGAAGCATGGTGGTGGCAAGCAAACGAAACCTCTAAAAAGAAGTCCCAGGGGCCGGGCGCAGTGGCTAACTCTTATGATCTTAGCGCTTTGAGAGGCCAAGGTGGGCAGATTGCCTGAACTCAGGAGTTCGAGACCAGCCTGGGCAACATG...
benign
310,561
Determine if the mutation at chromosome 20, position 761109 in gene SLC52A3 (solute carrier family 52 member 3) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Brown-Vialetto-van_Laere_syndrome_1']
CACCTTATATTTTCTGATTTTTTGAAACACGTGACTGTATTACCTATTCACAGTAAGTTAACAGGGATGGGAAGCATGGTGGTGGCAAGCAAACGAAACCTCTAAAAAGAAGTCCCAGGGGCCGGGCGCAGTGGCTAACTCTTATGATCTTAGCGCTTTGAGAGGCCAAGGTGGGCAGATTGCCTGAACTCAGGAGTTCGAGACCAGCCTGGGCAACATGGTGAGACCTCGTCTCTACTGAAAATACAAAAAATATGCCAGGTGTGGTAGTGCGCACCTGTAGTCCCAGCTACTCCGGAGACTGAGAGGCAGGAGAGTCA...
CACCTTATATTTTCTGATTTTTTGAAACACGTGACTGTATTACCTATTCACAGTAAGTTAACAGGGATGGGAAGCATGGTGGTGGCAAGCAAACGAAACCTCTAAAAAGAAGTCCCAGGGGCCGGGCGCAGTGGCTAACTCTTATGATCTTAGCGCTTTGAGAGGCCAAGGTGGGCAGATTGCCTGAACTCAGGAGTTCGAGACCAGCCTGGGCAACATGGTGAGACCTCGTCTCTACTGAAAATACAAAAAATATGCCAGGTGTGGTAGTGCGCACCTGTAGTCCCAGCTACTCCGGAGACTGAGAGGCAGGAGAGTCA...
pathogenic
310,563
The mutation impacting SLC52A3 (solute carrier family 52 member 3) on chromosome 20 at position 763817: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Brown-Vialetto-van_Laere_syndrome_1', 'Inborn_genetic_diseases']
TGTAGCCCCCAAAGCAGGTCCCAAGCACGGAGAGGACCCCCAGGAACAGCAGAGACCTAGAGGAAAGTAGGGGAGGTGAGTGGAGGTGAGAAGCCTGACCTCTGACCCCCCCGCCCCACTGGGCGGCATGTGGATGGCCAGTGTCTCCATAGTTAGTTTAGACCCATGTGGAAAATTCCAGGTTGCCTGGCTCAAGTGGGTCAGGGAGGCTCCTGAGCAGGCAGGGCTGGCCTGAGTCATCCCCAGCATTAACGGCAGGGCCTGGCACCCCGGCAAGAAAAACATAATGGACTCTGGCACCGGATGGTCCTGGTTCAAAT...
TGTAGCCCCCAAAGCAGGTCCCAAGCACGGAGAGGACCCCCAGGAACAGCAGAGACCTAGAGGAAAGTAGGGGAGGTGAGTGGAGGTGAGAAGCCTGACCTCTGACCCCCCCGCCCCACTGGGCGGCATGTGGATGGCCAGTGTCTCCATAGTTAGTTTAGACCCATGTGGAAAATTCCAGGTTGCCTGGCTCAAGTGGGTCAGGGAGGCTCCTGAGCAGGCAGGGCTGGCCTGAGTCATCCCCAGCATTAACGGCAGGGCCTGGCACCCCGGCAAGAAAAACATAATGGACTCTGGCACCGGATGGTCCTGGTTCAAAT...
pathogenic
310,592
Clinical significance of chromosome 20, position 764018, gene SLC52A3 (solute carrier family 52 member 3): benign or pathogenic? Name the disease(s) if pathogenic.
benign
CAGGGAGGCTCCTGAGCAGGCAGGGCTGGCCTGAGTCATCCCCAGCATTAACGGCAGGGCCTGGCACCCCGGCAAGAAAAACATAATGGACTCTGGCACCGGATGGTCCTGGTTCAAATCCCAGTTCTACTGTTTAAGCTGAGACTCGCCTCTGAGCCTCCAAATCGGAGTTTTGCAAGGCTGCATGACCTCCAGGAGCAGAGCATGCAGGCCTGGCGCCGCTGTGGGCCCACCTGGTGTTTACCTGCTGGCATTTCCTCCTGCAACACACCCTCAGCCTCAGCCAGGAAGCTGAGTTGAAGTGAAGATGGCTGGATCGG...
CAGGGAGGCTCCTGAGCAGGCAGGGCTGGCCTGAGTCATCCCCAGCATTAACGGCAGGGCCTGGCACCCCGGCAAGAAAAACATAATGGACTCTGGCACCGGATGGTCCTGGTTCAAATCCCAGTTCTACTGTTTAAGCTGAGACTCGCCTCTGAGCCTCCAAATCGGAGTTTTGCAAGGCTGCATGACCTCCAGGAGCAGAGCATGCAGGCCTGGCGCCGCTGTGGGCCCACCTGGTGTTTACCTGCTGGCATTTCCTCCTGCAACACACCCTCAGCCTCAGCCAGGAAGCTGAGTTGAAGTGAAGATGGCTGGATCGG...
benign
310,600
The genetic variant at chromosome 20, position 765779, affecting gene SLC52A3 (solute carrier family 52 member 3): benign or pathogenic? Disease name(s) if pathogenic?
benign
GTCCACCGTGCCTGCAGGGCCCAAGTCATTCTCTTCCCGCGGCCGGATGGAGTGGAGGGTGACCTGGTCATTGAGGAGGTCTTCCACGGAAGCCTCCCAGCACCTGGGTTGACGCTGGAGGACAAAGAACGCCACGAGGCAGCAGGCCATCATGATGGATAGGAGGAGGAAGAAGACCAGGGGTGAGAAGTGGGCGGGAAGGTAGCGGCTCTCCAGGTGGGACAAGGGTGCTTCCATTCCGGGGAGGGCGGACACCAAAGCTCTGGGAACTCCCTGCAAAGGACAAGACAGATCCCTGGTCAGGGGAGGGGATCAGGCTG...
GTCCACCGTGCCTGCAGGGCCCAAGTCATTCTCTTCCCGCGGCCGGATGGAGTGGAGGGTGACCTGGTCATTGAGGAGGTCTTCCACGGAAGCCTCCCAGCACCTGGGTTGACGCTGGAGGACAAAGAACGCCACGAGGCAGCAGGCCATCATGATGGATAGGAGGAGGAAGAAGACCAGGGGTGAGAAGTGGGCGGGAAGGTAGCGGCTCTCCAGGTGGGACAAGGGTGCTTCCATTCCGGGGAGGGCGGACACCAAAGCTCTGGGAACTCCCTGCAAAGGACAAGACAGATCCCTGGTCAGGGGAGGGGATCAGGCTG...
benign
310,623
Variant at chromosome position 2431011, chromosome 20, gene TGM6 (transglutaminase 6): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
ATAGGCACAACACCACGCCCTGCTAATTTTGTAATTTTTTTTAGTAGAGACAGGGTTTCAACATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTTCACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACGGCACCCGGCCTATAATTATTATTTATTACTGTTATTGTAATAAAGGTTCTTCCAATAATGACCTACTGAACTAAGGGAGCCCATAAAACAAAATCATACTTTAACACATGAATCACCCTACTGGCATTCAGGAGAATCTACGATATGCAAAGCCCTGGGGTAGCAGAG...
ATAGGCACAACACCACGCCCTGCTAATTTTGTAATTTTTTTTAGTAGAGACAGGGTTTCAACATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTTCACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACGGCACCCGGCCTATAATTATTATTTATTACTGTTATTGTAATAAAGGTTCTTCCAATAATGACCTACTGAACTAAGGGAGCCCATAAAACAAAATCATACTTTAACACATGAATCACCCTACTGGCATTCAGGAGAATCTACGATATGCAAAGCCCTGGGGTAGCAGAG...
benign
310,737
A genetic variant at chromosome 20, position 2660567, affecting gene IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Retinitis_pigmentosa_46']
GAACCTGTGGGGGAGAATCATCATCATCCATGTGGCCTGGGCTCCATCCTAACAATCCCCATCACCACCCAACAGTCTGTCCCCTAAGGAAGCCGGCCCAAGGACAACCTAGGCTCTACCCAGCAAGGTGACCATGGTCCACTGCTTAGAGGCACAAGGTCTCTTCCCTGGTACACTGCACTGAAGGGTATGGGGAGTGTGGTCCTTGCAAGGTTGGAAGAAATAAAGGGCTCTAGCTCCCTTTAGTCTGCAGGTGACCGATGACAGACTTGATGAAGTCGGTTGTGGTGCTGTAGCCGCCCATGTCTCGAGTCCGCACC...
GAACCTGTGGGGGAGAATCATCATCATCCATGTGGCCTGGGCTCCATCCTAACAATCCCCATCACCACCCAACAGTCTGTCCCCTAAGGAAGCCGGCCCAAGGACAACCTAGGCTCTACCCAGCAAGGTGACCATGGTCCACTGCTTAGAGGCACAAGGTCTCTTCCCTGGTACACTGCACTGAAGGGTATGGGGAGTGTGGTCCTTGCAAGGTTGGAAGAAATAAAGGGCTCTAGCTCCCTTTAGTCTGCAGGTGACCGATGACAGACTTGATGAAGTCGGTTGTGGTGCTGTAGCCGCCCATGTCTCGAGTCCGCACC...
pathogenic
310,791
Determine if the mutation at chromosome 20, position 3218578 in gene ITPA (inosine triphosphatase) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Developmental_and_epileptic_encephalopathy,_35', 'Hypodontia', 'Inosine_triphosphatase_deficiency']
TACAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGT...
TACAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGT...
pathogenic
310,862
Clinical impact (benign or pathogenic) of the variant at chromosome 20, location 3218622, gene ITPA: what disease(s) if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Inosine_triphosphatase_deficiency']
CTCCCTAGTAGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCACTCCCAGCCTATTTTATT...
CTCCCTAGTAGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCACTCCCAGCCTATTTTATT...
pathogenic
310,864
Clinical classification of chromosome 20, position 3218631, gene ITPA: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Developmental_and_epileptic_encephalopathy,_35', 'Inosine_triphosphatase_deficiency']
AGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCACTCCCAGCCTATTTTATTTTTTTGAGA...
AGCTGGGATTACAGGCACCTGCCACCATGACCAGCTAATTTTTTGTATTTTTTGTAGAGGGGTTTCACTATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCACCCATCGCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGATCCACTGAGCCCGGCTTAATTTTTGTATTTTTAGTAGACACGGAGTTTCGCCATGTTGGCCAGGCTAGTTTCAAACACCTGACCTCAGGTGGTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCACTCCCAGCCTATTTTATTTTTTTGAGA...
pathogenic
310,865
Mutation found at chromosome 20 position 3228592, gene SLC4A11 (solute carrier family 4 member 11): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
GGGGTCTGAGCACCTCTCGCTACTCCTGTTACGGTTGGGCCTCCTTCTTCCCCTGTTCACGGCCTCTGCCTCTTCTGTTGGGGCTGCTGTCCTTTGCTGGTTTGCAGGAATTCTTTGCATATTTCAGATATATTTTCAGTTTTAGATGCAGCCAATCTCTTCTGTCGGCCAACTTAGTCCATGGGGCATGTGTCAAGCCAGTCCAGGAGGTGATGTGAGCCCCAGGTGTTCCTGCTGACCACTGATGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACC...
GGGGTCTGAGCACCTCTCGCTACTCCTGTTACGGTTGGGCCTCCTTCTTCCCCTGTTCACGGCCTCTGCCTCTTCTGTTGGGGCTGCTGTCCTTTGCTGGTTTGCAGGAATTCTTTGCATATTTCAGATATATTTTCAGTTTTAGATGCAGCCAATCTCTTCTGTCGGCCAACTTAGTCCATGGGGCATGTGTCAAGCCAGTCCAGGAGGTGATGTGAGCCCCAGGTGTTCCTGCTGACCACTGATGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACC...
pathogenic
310,889
Clinically, how would you classify the variant at chromosome 20, position 3228698, gene SLC4A11 (solute carrier family 4 member 11): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
GGAATTCTTTGCATATTTCAGATATATTTTCAGTTTTAGATGCAGCCAATCTCTTCTGTCGGCCAACTTAGTCCATGGGGCATGTGTCAAGCCAGTCCAGGAGGTGATGTGAGCCCCAGGTGTTCCTGCTGACCACTGATGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCAC...
GGAATTCTTTGCATATTTCAGATATATTTTCAGTTTTAGATGCAGCCAATCTCTTCTGTCGGCCAACTTAGTCCATGGGGCATGTGTCAAGCCAGTCCAGGAGGTGATGTGAGCCCCAGGTGTTCCTGCTGACCACTGATGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCAC...
pathogenic
310,893
Is the genetic change at chromosome 20, position 3228837, within gene SLC4A11 (solute carrier family 4 member 11) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
TGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGG...
TGCTGCGCACCCGGCACTCCCCTGAGCCTCAGAGCCATATTCCCTGTTGTCGGCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGG...
pathogenic
310,896
Located at chromosome 20 position 3228889, the variant affecting gene SLC4A11 (solute carrier family 4 member 11)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
GCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGGTCCCTCCCGCCCCACTGCTCTTCACCAGCCACAGCGCCTCAGTGGCCCCAAG...
GCTGCCATTGGGAGACCCTGACCCACCAACAAATGAGCAAGCCAGAAACACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGGTCCCTCCCGCCCCACTGCTCTTCACCAGCCACAGCGCCTCAGTGGCCCCAAG...
pathogenic
310,899
Is the genetic variant on chromosome 20, position 3228937, gene SLC4A11 (solute carrier family 4 member 11), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['SLC4A11-related_disorder']
CACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGGTCCCTCCCGCCCCACTGCTCTTCACCAGCCACAGCGCCTCAGTGGCCCCAAGCCCTCGCTCCTCTGGACCCTTGCACATGCTGTTCCCAGAACGCTTTCC...
CACTGCACCTTCTCCCTCCGTCAAACCATTCCCACCCCGTGTCCTGCCGTCGGCAGTCCTCCCACCTCCCTCCATCGCCACCAGTGCTGCCCCTGCCCTGTAAAATCCAGGATCCGCACAACAGATGGGATGGTTCACAAGTGCTCCACACGAAGCCTCGGCCTCCCGGCAGGCAGCTTTCATCTGAGAGTCACAGGGCCCTTTGCTGTCACCCTGATGGTCCCTCCCGCCCCACTGCTCTTCACCAGCCACAGCGCCTCAGTGGCCCCAAGCCCTCGCTCCTCTGGACCCTTGCACATGCTGTTCCCAGAACGCTTTCC...
pathogenic
310,901
A mutation at chromosome position 3231075 on chromosome 20 in gene SLC4A11 (solute carrier family 4 member 11): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
ACTCGTGGACAGAGCCCCACAGCAGAGGCCCGGGCCCCGCCCACCCCACCCTCACCCACCCTCCACACCTGTTCTCCGGTGCATTCACCAAGGCGGCCACCAAGTTCTGCTCGATGAAGAAGAGCATGGACAGCAGGAAGCCGAGGCCCATGGCACCGCTGACGGCCCTCAGGGACAGCGACTGGATCTGCGCCATCGCAAAGGGGCTCTCGCTGGGGTTGTAGCGGAACTTGCTCACTGCAGTAGGGGACAGGCTACTGCTATGCCTGCAGCGCCTGGGGAGCTACCCCACGTCACCCACCGCCCGGCCCCAACTCACT...
ACTCGTGGACAGAGCCCCACAGCAGAGGCCCGGGCCCCGCCCACCCCACCCTCACCCACCCTCCACACCTGTTCTCCGGTGCATTCACCAAGGCGGCCACCAAGTTCTGCTCGATGAAGAAGAGCATGGACAGCAGGAAGCCGAGGCCCATGGCACCGCTGACGGCCCTCAGGGACAGCGACTGGATCTGCGCCATCGCAAAGGGGCTCTCGCTGGGGTTGTAGCGGAACTTGCTCACTGCAGTAGGGGACAGGCTACTGCTATGCCTGCAGCGCCTGGGGAGCTACCCCACGTCACCCACCGCCCGGCCCCAACTCACT...
benign
310,921
Does the genetic variant at chromosome 20, position 3233950, impacting gene SLC4A11 (solute carrier family 4 member 11), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Corneal_dystrophy-perceptive_deafness_syndrome']
TCTGTCTAGGCCTCCCAAAGTGCTGGGATTACAGGCACGAGCCACTGTGCCCAGATGCTGGTAGCAGGTTTTATTCCACAAAGTTCAGGCATTAGTGTACTCTGCCATGATTTCAACCAGGTCAGCAGATCACCGCAACTACCATCGATCTATATTTTTGTTATAAACTCATGATTTCTTATAAACTCAAGATATTACTTTTGTCCTAAGCAACAAAAGTCTGTGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAG...
TCTGTCTAGGCCTCCCAAAGTGCTGGGATTACAGGCACGAGCCACTGTGCCCAGATGCTGGTAGCAGGTTTTATTCCACAAAGTTCAGGCATTAGTGTACTCTGCCATGATTTCAACCAGGTCAGCAGATCACCGCAACTACCATCGATCTATATTTTTGTTATAAACTCATGATTTCTTATAAACTCAAGATATTACTTTTGTCCTAAGCAACAAAAGTCTGTGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAG...
pathogenic
310,932
The mutation in gene SLC4A11 (solute carrier family 4 member 11) at chromosome 20, position 3234173—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
pathogenic
310,933
Clinically, how would you classify the variant at chromosome 20, position 3234173, gene SLC4A11 (solute carrier family 4 member 11): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy,_Fuchs_endothelial,_4', 'Corneal_dystrophy-perceptive_deafness_syndrome']
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
pathogenic
310,934
Does the variant on chromosome 20 at location 3234173 affecting gene SLC4A11 (solute carrier family 4 member 11) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Congenital_hereditary_endothelial_dystrophy_of_cornea', 'Corneal_dystrophy-perceptive_deafness_syndrome']
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
TGTGATCACAGATAATGAAACCACAGTGGAGAAAAATGTTTCCCCAGCTACGTTTCCCCAGTGGTATTTGCACTGTCTGCTGGTTTGACTTTCAGAGAGGGTCCAAGCCCGTCAGGCACTCTCTCTCTCGCCCGGCCAAGGTGAAGCCCGTCCGTGAACCATGAACTCACGAACTCAGTGTCCAGCCCTCATCACAGCAACCTGCTCACCTAGGGGCAGTGTCTGCCCGTCTGTTGCTCAAAGCTCTAGTCCCGGGGCACTGTGCATGTTTGCTGTAGAAGAGGCCCGTGCCTGGCAGGGCATGGTGGCTCACGCCCATA...
pathogenic
310,935
Does the variant on chromosome 20 at location 3668985 affecting gene ADAM33 (ADAM metallopeptidase domain 33) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
GGTTTCACCACATTGGCCAGGCTGGTCTCGAACTTCTGACCTCAAATGATCCTCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTTAGATTCTCTATTTTATGATGGTTTAACATCTCGGGGTGGGGGCTTGTTGGCTGGAGAGAAACTGCTTGATTCCTGGAGATCAGAAACAACTCATGCCTTTCATATGCAAACCGACCAGTCTTGAGTCCATACACCAACCACCCCCTTCAAGGAACTCTCACATACGAAACCAGTATTTCCCCTGCCCTAAACCAGCTCAGGGCCAGGCA...
GGTTTCACCACATTGGCCAGGCTGGTCTCGAACTTCTGACCTCAAATGATCCTCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTTAGATTCTCTATTTTATGATGGTTTAACATCTCGGGGTGGGGGCTTGTTGGCTGGAGAGAAACTGCTTGATTCCTGGAGATCAGAAACAACTCATGCCTTTCATATGCAAACCGACCAGTCTTGAGTCCATACACCAACCACCCCCTTCAAGGAACTCTCACATACGAAACCAGTATTTCCCCTGCCCTAAACCAGCTCAGGGCCAGGCA...
benign
310,965
The chromosome 20, position 3889432 genetic variant in gene PANK2: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Pigmentary_pallidal_degeneration']
CTGCAACCTCCGCCTACCGGATTCAAGTGACTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTGTTTGTTTTTTTTAGTAGAGACGGGGTTTCCCTGTGTTGGCCAGGCTGGTCTCGGACTCCTGACCTTGTGATTCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTTGAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATA...
CTGCAACCTCCGCCTACCGGATTCAAGTGACTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTGTTTGTTTTTTTTAGTAGAGACGGGGTTTCCCTGTGTTGGCCAGGCTGGTCTCGGACTCCTGACCTTGTGATTCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTTGAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATA...
pathogenic
310,992
Clinically, how would you classify the variant at chromosome 20, position 3889603, gene PANK2: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Hypoprebetalipoproteinemia,_acanthocytosis,_retinitis_pigmentosa,_and_pallidal_degeneration', 'Pigmentary_pallidal_degeneration']
TCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTTGAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGAC...
TCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTTGAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGAC...
pathogenic
310,999
Chromosome 20, position 3889645, gene PANK2: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Pigmentary_pallidal_degeneration', 'Retinal_dystrophy']
GAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGG...
GAGCCACTGCGCCCGGCCGCTTTCTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGG...
pathogenic
311,002
Does the variant on chromosome 20 at location 3889668 affecting gene PANK2 have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Hypoprebetalipoproteinemia,_acanthocytosis,_retinitis_pigmentosa,_and_pallidal_degeneration', 'Pigmentary_pallidal_degeneration']
CTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGGTGGAGAGAGGAGGCAGAAAGAGA...
CTTTTGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGGTGGAGAGAGGAGGCAGAAAGAGA...
pathogenic
311,003
Variant chromosome 20, position 3889672, gene PANK2: benign or pathogenic? Disease(s)?
pathogenic; ['Pigmentary_pallidal_degeneration']
TGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGGTGGAGAGAGGAGGCAGAAAGAGAGGCA...
TGGTTATCATAAGGCGGGCAGTAGCTGAACTTCTCAGGAGTCCAAGCTCTGTCATTCTTTAGGCTTTGTGCTTCTGGATAAGTTACCTCATCATCCAAATGTTACTGCAAGGACTAAGTGAGATGTAGAGGCAGTGGGCAAATTGTGTAAAAATACTACTGTTTCAAGTGTTTTGATGTTGGAGTTCATCTTGCCAGCCAAGGGATGATGATACTTTGATTCTTCAGGATGATCAGAGCTCAGACTTGGACGGAAGCTCCCTCAGGTCAAGGAGGACCACATTTTTTGGGGGGTGGAGAGAGGAGGCAGAAAGAGAGGCA...
pathogenic
311,005
Variant on chromosome 20, at position 3908117, affecting PANK2 (pantothenate kinase 2): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Pigmentary_pallidal_degeneration']
ACAGATGCTTTTTGACTTACGATGTTTATGCTACATTCCATAAACCCATCAGAAGTTCAAAATACTGTAAATCAGGCTGGGCGCAGTGGTTCACACTTGTAATCCCAGCACTTTGGGAGGCTGACCTGGGTGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGCAACATGGGGAAACCCTGTTTCTACAAAAAATACAAAAATTAGGTGGGTGTGGTGGCATGCACCTTTAGTCCCAGCTGCTCAGGAGGCTGAGATAGGAGGATTACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGGCGTTGC...
ACAGATGCTTTTTGACTTACGATGTTTATGCTACATTCCATAAACCCATCAGAAGTTCAAAATACTGTAAATCAGGCTGGGCGCAGTGGTTCACACTTGTAATCCCAGCACTTTGGGAGGCTGACCTGGGTGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGCAACATGGGGAAACCCTGTTTCTACAAAAAATACAAAAATTAGGTGGGTGTGGTGGCATGCACCTTTAGTCCCAGCTGCTCAGGAGGCTGAGATAGGAGGATTACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGGCGTTGC...
pathogenic
311,019
Evaluate this variant at chromosome 20, position 3908120, gene PANK2 (pantothenate kinase 2): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Pigmentary_pallidal_degeneration']
GATGCTTTTTGACTTACGATGTTTATGCTACATTCCATAAACCCATCAGAAGTTCAAAATACTGTAAATCAGGCTGGGCGCAGTGGTTCACACTTGTAATCCCAGCACTTTGGGAGGCTGACCTGGGTGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGCAACATGGGGAAACCCTGTTTCTACAAAAAATACAAAAATTAGGTGGGTGTGGTGGCATGCACCTTTAGTCCCAGCTGCTCAGGAGGCTGAGATAGGAGGATTACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGGCGTTGCATT...
GATGCTTTTTGACTTACGATGTTTATGCTACATTCCATAAACCCATCAGAAGTTCAAAATACTGTAAATCAGGCTGGGCGCAGTGGTTCACACTTGTAATCCCAGCACTTTGGGAGGCTGACCTGGGTGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGCAACATGGGGAAACCCTGTTTCTACAAAAAATACAAAAATTAGGTGGGTGTGGTGGCATGCACCTTTAGTCCCAGCTGCTCAGGAGGCTGAGATAGGAGGATTACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGGCGTTGCATT...
pathogenic
311,020
Considering the genetic mutation at chromosome 20, position 3910677, impacting PANK2 (pantothenate kinase 2): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Pigmentary_pallidal_degeneration']
TTTTCAGTCTTGTCTACCACATAATTTCTCTTGTCTCCCTCAGTTGTTTGCTGGCATGTTCACTAACTGAAAAAAATAAGGAACTCTGGTCAAAAGTGGTGTTTTCAGGCTCAGGGCTGGTCTGAGATGGGTGACTGCAGAGCCCTCCTCTCCCAGAATGCTTTCTGATGTGTTCTGTGCTGCACACTTAACTGGAGTCTCGCCACCATGTCTGGCCCCTGGGGAATGCTGCCAGGCGCTCTATCTTGCTTTCATTGAGTGAACACTGGAGAACATTGTGAGCAAGACCTTGAGGCTAGGTCCTTTCAGGGTGGATGGTG...
TTTTCAGTCTTGTCTACCACATAATTTCTCTTGTCTCCCTCAGTTGTTTGCTGGCATGTTCACTAACTGAAAAAAATAAGGAACTCTGGTCAAAAGTGGTGTTTTCAGGCTCAGGGCTGGTCTGAGATGGGTGACTGCAGAGCCCTCCTCTCCCAGAATGCTTTCTGATGTGTTCTGTGCTGCACACTTAACTGGAGTCTCGCCACCATGTCTGGCCCCTGGGGAATGCTGCCAGGCGCTCTATCTTGCTTTCATTGAGTGAACACTGGAGAACATTGTGAGCAAGACCTTGAGGCTAGGTCCTTTCAGGGTGGATGGTG...
pathogenic
311,032
Is the genetic change at chromosome 20, position 3910770, within gene PANK2 (pantothenate kinase 2) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Pigmentary_pallidal_degeneration']
AAGTGGTGTTTTCAGGCTCAGGGCTGGTCTGAGATGGGTGACTGCAGAGCCCTCCTCTCCCAGAATGCTTTCTGATGTGTTCTGTGCTGCACACTTAACTGGAGTCTCGCCACCATGTCTGGCCCCTGGGGAATGCTGCCAGGCGCTCTATCTTGCTTTCATTGAGTGAACACTGGAGAACATTGTGAGCAAGACCTTGAGGCTAGGTCCTTTCAGGGTGGATGGTGGGGGTAGGCCGGAGAACTGACAAATGAATAAGCCAAGATCCTGACCGTCAGGGTGCAATACAGATTGAAAATGTCTTCAGTGACTGACTGTTT...
AAGTGGTGTTTTCAGGCTCAGGGCTGGTCTGAGATGGGTGACTGCAGAGCCCTCCTCTCCCAGAATGCTTTCTGATGTGTTCTGTGCTGCACACTTAACTGGAGTCTCGCCACCATGTCTGGCCCCTGGGGAATGCTGCCAGGCGCTCTATCTTGCTTTCATTGAGTGAACACTGGAGAACATTGTGAGCAAGACCTTGAGGCTAGGTCCTTTCAGGGTGGATGGTGGGGGTAGGCCGGAGAACTGACAAATGAATAAGCCAAGATCCTGACCGTCAGGGTGCAATACAGATTGAAAATGTCTTCAGTGACTGACTGTTT...
pathogenic
311,033
For chromosome 20, position 3912471, gene PANK2 (pantothenate kinase 2): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Pigmentary_pallidal_degeneration']
GCTCCTAAATCTGTTCTGTAAAGCATGCACAAATAATACACATCTGTGAGTGCACTTTCATGGTTGTTTCACGTAGTGGGGATGCCTTATTGAATGGAATTTTTGTTTCTGTTGGCTTATTAAAAAGTCTGAGTACATTCTTATTTCATTACAGATAGGTGATCTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCAGTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAGTGTCAGAAGTTACCATTTGATTTGAAAAATCCGT...
GCTCCTAAATCTGTTCTGTAAAGCATGCACAAATAATACACATCTGTGAGTGCACTTTCATGGTTGTTTCACGTAGTGGGGATGCCTTATTGAATGGAATTTTTGTTTCTGTTGGCTTATTAAAAAGTCTGAGTACATTCTTATTTCATTACAGATAGGTGATCTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCAGTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAGTGTCAGAAGTTACCATTTGATTTGAAAAATCCGT...
pathogenic
311,037
A genetic variant at chromosome 20, position 3912490, affecting gene PANK2 (pantothenate kinase 2)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Pigmentary_pallidal_degeneration']
AAAGCATGCACAAATAATACACATCTGTGAGTGCACTTTCATGGTTGTTTCACGTAGTGGGGATGCCTTATTGAATGGAATTTTTGTTTCTGTTGGCTTATTAAAAAGTCTGAGTACATTCTTATTTCATTACAGATAGGTGATCTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCAGTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAGTGTCAGAAGTTACCATTTGATTTGAAAAATCCGTATCCTCTGCTTCTGGTGAA...
AAAGCATGCACAAATAATACACATCTGTGAGTGCACTTTCATGGTTGTTTCACGTAGTGGGGATGCCTTATTGAATGGAATTTTTGTTTCTGTTGGCTTATTAAAAAGTCTGAGTACATTCTTATTTCATTACAGATAGGTGATCTTCAGCTTTGCAAACTGGATGAACTAGATTGCTTGATCAAAGGAATTTTATACATTGACTCAGTCGGATTCAATGGACGGTCACAGTGCTATTACTTTGAAAACCCTGCTGATTCTGAAAAGTGTCAGAAGTTACCATTTGATTTGAAAAATCCGTATCCTCTGCTTCTGGTGAA...
pathogenic
311,038
Evaluate the clinical significance of the mutation at chromosome 20, position 3916912 in gene PANK2 (pantothenate kinase 2): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTG...
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTG...
benign
311,043
Is the variant located on chromosome 20 at position 3916912, gene PANK2 (pantothenate kinase 2), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTG...
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTG...
benign
311,044
Determine if the mutation at chromosome 20, position 3916955 in gene PANK2 (pantothenate kinase 2) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Pigmentary_pallidal_degeneration']
GCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTGTAAGAAATCTAAGATCATGAAGAATTGCCTAATTTAAGATCAT...
GCCCGAACATCTTTTCATGTGTTTACTGGCCATCTGTCTGTAGTCTTTGGATAAATGTCTGCTGAAGTCTATTGCTAAGTTTTTAGTTGGATTGTCTTTTTATTATTGAGTTCTGGATACAAGTCCCTTATTAGATACATAATTCGCAAATGTTTTGTCCCATTTTGTTAGTTGTCTTTTCACTTCCTTGATGGTGTCCTTTGCAGCATGGAAATTTTAAATTTTGATGAAGTTAATCTTATCTATCTTCTGTCACTTGTGCTTTTGGTGTTATGTGTAAGAAATCTAAGATCATGAAGAATTGCCTAATTTAAGATCAT...
pathogenic
311,046
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 20, position 4699379, gene PRNP (prion protein (Kanno blood group)). What disease(s) is it linked to if pathogenic?
benign
ACCAAACTCCCGCCCTAAAGGAGCCTGCACTCCCGTGGAGAACATGAATAATAAGCACAGAGGAAATAACATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTA...
ACCAAACTCCCGCCCTAAAGGAGCCTGCACTCCCGTGGAGAACATGAATAATAAGCACAGAGGAAATAACATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTA...
benign
311,061
Chromosome 20, position 4699442, gene PRNP (prion protein (Kanno blood group)): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
AAATAACATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTATGGCCACGACTTTGTGTTTTATCCAGAGTACAAAGGAGCCTCACTGAGGGACAAGGGAAGTGG...
AAATAACATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTATGGCCACGACTTTGTGTTTTATCCAGAGTACAAAGGAGCCTCACTGAGGGACAAGGGAAGTGG...
benign
311,064
Chromosome 20, position 4699448, gene PRNP (prion protein (Kanno blood group)): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
CATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTATGGCCACGACTTTGTGTTTTATCCAGAGTACAAAGGAGCCTCACTGAGGGACAAGGGAAGTGGCATGAT...
CATAATATCTCAAGTAGCTGTAACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATGGGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAACAGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGTTACATGGGGCCCAGCCAGTATGGCCACGACTTTGTGTTTTATCCAGAGTACAAAGGAGCCTCACTGAGGGACAAGGGAAGTGGCATGAT...
benign
311,067
Variant at chromosome 20, position 5314311, gene PROKR2 (prokineticin receptor 2): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Hypogonadotropic_hypogonadism_2_with_or_without_anosmia', 'Hypogonadotropic_hypogonadism_3_with_or_without_anosmia', 'Inborn_genetic_diseases', 'PROKR2-related_disorder', 'likely other unspecified diseases']
CGCCCAACTAATTTTTGTATTTTTAGTAGAGAAGGGGTTTCACCATGCTGGCCAGGCTGGTCTCAAATTCCTGACCTCAGGTGATCTGCCCGTCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGCACCCGGGCTGACTTTGTGTCTTTCCATCAAATGATACTTTGCACCATTTTCCCTGGAGAATTGTGTGCAGTTGGTTGATAGGTACACATTTCATAAGGGATGGTTTCAGGGCTGGTGAGCCTGAGTTGTAGCAAAATCGTTTTTCCTGCAGAAATTATGTTATACAAAGGAAGGAGGATGCTTC...
CGCCCAACTAATTTTTGTATTTTTAGTAGAGAAGGGGTTTCACCATGCTGGCCAGGCTGGTCTCAAATTCCTGACCTCAGGTGATCTGCCCGTCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGCACCCGGGCTGACTTTGTGTCTTTCCATCAAATGATACTTTGCACCATTTTCCCTGGAGAATTGTGTGCAGTTGGTTGATAGGTACACATTTCATAAGGGATGGTTTCAGGGCTGGTGAGCCTGAGTTGTAGCAAAATCGTTTTTCCTGCAGAAATTATGTTATACAAAGGAAGGAGGATGCTTC...
pathogenic
311,130
For chromosome 20, position 6077394, gene FERMT1 (FERM domain containing kindlin 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
AAAATAATAGAACTGAGAAATAGGACTGAGAAATGACCAACATCAAGTATATACGGTACACTTAGCACTTGTTTCTATAGAAAACATTTCAAATCAAGTTCTTTATGATGTGAACCAGATTTTCCAAATGCCTAAACCACTTCTGAGCTTTAAGCAAGGCCTCAGAAATTCAGCGGGTGCCTGGGAGGCTTCATTCACATTCACCTCTAAGGAGAGGCTAAAAGAGGAATTTCCAGATGGCAGCTACTGGCTCAGAACCAGGGGGTCCCTTGCCAAGTCTGTCTCTATGTGGCTCCCGGAATTGCTGAGGTCTCACTTCT...
AAAATAATAGAACTGAGAAATAGGACTGAGAAATGACCAACATCAAGTATATACGGTACACTTAGCACTTGTTTCTATAGAAAACATTTCAAATCAAGTTCTTTATGATGTGAACCAGATTTTCCAAATGCCTAAACCACTTCTGAGCTTTAAGCAAGGCCTCAGAAATTCAGCGGGTGCCTGGGAGGCTTCATTCACATTCACCTCTAAGGAGAGGCTAAAAGAGGAATTTCCAGATGGCAGCTACTGGCTCAGAACCAGGGGGTCCCTTGCCAAGTCTGTCTCTATGTGGCTCCCGGAATTGCTGAGGTCTCACTTCT...
benign
311,160
The mutation in gene BMP2 (bone morphogenetic protein 2) at chromosome 20, position 6770351—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Short_stature,_facial_dysmorphism,_and_skeletal_anomalies_with_or_without_cardiac_anomalies_1']
CCGAGATCGCCGCCGTGCCCTTCCCTGGACCCGGCGTCGCCCAGGATGGCTGCCCCGAGCCATGGGCCGCGGCGGAGCTAGCGCGGAGCGCCCGACCCTCGACCCCCGAGTCCCGGAGCCGGCCCCGCGCGGGGCCACGCGTCCCTCGGGCGCTGGTTCCTAAGGAGGACGACAGCACCAGCTTCTCCTTTCTCCCTTCCCTTCCCTGCCCCGCACTCCTCCCCCTGCTCGCTGTTGTTGTGTGTCAGCACTTGGCTGGGGACTTCTTGAACTTGCAGGGAGAATAACTTGCGCACCCCACTTTGCGCCGGTGCCTTTGC...
CCGAGATCGCCGCCGTGCCCTTCCCTGGACCCGGCGTCGCCCAGGATGGCTGCCCCGAGCCATGGGCCGCGGCGGAGCTAGCGCGGAGCGCCCGACCCTCGACCCCCGAGTCCCGGAGCCGGCCCCGCGCGGGGCCACGCGTCCCTCGGGCGCTGGTTCCTAAGGAGGACGACAGCACCAGCTTCTCCTTTCTCCCTTCCCTTCCCTGCCCCGCACTCCTCCCCCTGCTCGCTGTTGTTGTGTGTCAGCACTTGGCTGGGGACTTCTTGAACTTGCAGGGAGAATAACTTGCGCACCCCACTTTGCGCCGGTGCCTTTGC...
pathogenic
311,230
Gene BMP2 (bone morphogenetic protein 2) variant at chromosome 20, position 6778297—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Short_stature,_facial_dysmorphism,_and_skeletal_anomalies_with_or_without_cardiac_anomalies_1']
TGGATGGATCCTGAAAGGTATTCCCCAGAGGTTTGGATTAATAGGCACAAGGGAACCCTAAAGGACTCTATTGGCCTGATACTCCCCATATCCACGTAGAAGAGCTTTAGAAGAACCTTCTGTTCTGAGACCCTGGCTGGGCCCACCCAGAGCTGGCCCATTCAACTCTTACTCCTTTGCCACCACTAATGGTTCTTCTACTAGTTTTTATATTATTTAACAAAAAGGCACTTTAAAAATGCACTCCTGGCAATCTATACTGGAATATGAAAAACATGCTGCAAAACCTTGACACTCCAAGTGTGGTCTTACAGTTCCCA...
TGGATGGATCCTGAAAGGTATTCCCCAGAGGTTTGGATTAATAGGCACAAGGGAACCCTAAAGGACTCTATTGGCCTGATACTCCCCATATCCACGTAGAAGAGCTTTAGAAGAACCTTCTGTTCTGAGACCCTGGCTGGGCCCACCCAGAGCTGGCCCATTCAACTCTTACTCCTTTGCCACCACTAATGGTTCTTCTACTAGTTTTTATATTATTTAACAAAAAGGCACTTTAAAAATGCACTCCTGGCAATCTATACTGGAATATGAAAAACATGCTGCAAAACCTTGACACTCCAAGTGTGGTCTTACAGTTCCCA...
pathogenic
311,234
Is the chromosome 20, position 8684855 variant in PLCB1 (phospholipase C beta 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
ACAGAAAGAAAATTGGTTATGTGTATTAAAATCCTCAAAAGTATGCGAAGTCTTTGAATCAGAAATTCTATTTCTGGGAATTCATCCTGAAGAAATAATTAAGTATTTATACAAAGATGTAACCATCAGAGCAGTCAATGCAATGTCATTTATACTAGTGAAAAAATTAGAAACAACTTTAATGATCAATGATAATAGAATATTATTTCATATTATACTGCTATATTTTATGATATAAAAATATAGATAGTTGCATATTTTATGCTATAGTTAAATATCCGCATAGAATTTATTTTTACATTAAAAATGTTCATAATATA...
ACAGAAAGAAAATTGGTTATGTGTATTAAAATCCTCAAAAGTATGCGAAGTCTTTGAATCAGAAATTCTATTTCTGGGAATTCATCCTGAAGAAATAATTAAGTATTTATACAAAGATGTAACCATCAGAGCAGTCAATGCAATGTCATTTATACTAGTGAAAAAATTAGAAACAACTTTAATGATCAATGATAATAGAATATTATTTCATATTATACTGCTATATTTTATGATATAAAAATATAGATAGTTGCATATTTTATGCTATAGTTAAATATCCGCATAGAATTTATTTTTACATTAAAAATGTTCATAATATA...
benign
311,272
Regarding the variant at chromosome 20 and position 10405546, affecting gene MKKS (MKKS centrosomal shuttling protein): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
GAATCACCCCAGGCTTCCTCAGGAGGTAGTTCTTTAAGTACAGTTCCTGGAACACAGTTGCTTTCCATCTGTAGACCCATGAAACTAGAGAAAAGTTATCTGCCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGA...
GAATCACCCCAGGCTTCCTCAGGAGGTAGTTCTTTAAGTACAGTTCCTGGAACACAGTTGCTTTCCATCTGTAGACCCATGAAACTAGAGAAAAGTTATCTGCCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGA...
pathogenic
311,465
Benign or pathogenic: chromosome 20, position 10405591, gene MKKS (MKKS centrosomal shuttling protein) variant? Disease(s) if pathogenic?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CCTGGAACACAGTTGCTTTCCATCTGTAGACCCATGAAACTAGAGAAAAGTTATCTGCCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGAGTAAAACTTTTGATAAATATTTTATGAGACTTCAGGTGGGGCTGA...
CCTGGAACACAGTTGCTTTCCATCTGTAGACCCATGAAACTAGAGAAAAGTTATCTGCCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGAGTAAAACTTTTGATAAATATTTTATGAGACTTCAGGTGGGGCTGA...
pathogenic
311,466
Does the variant impacting MKKS (MKKS centrosomal shuttling protein) on chromosome 20, position 10405648, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGAGTAAAACTTTTGATAAATATTTTATGAGACTTCAGGTGGGGCTGATACCTAACATATATGGATGGCATTGCTGCTTGTATTGCTAGTTTTTTCCTTTGGCTC...
CCTTCTACTCACAGCATAAAATTATGGATAAGGCATAACCATAACCATCACCATAACATTCTGTCCACAAAGCTGGGAAATGGGAGACATAAAGGAGTCACTAAGTCTAGCCCATGCTCAAGGGGAGGAAATTATGCAAGGTCTGAAACTAGGAGGTGGGGCCACCTTAGAGGCTGCCTACCACACTGCCCTTCTATTTGATTGTAATAATAAAAGGAGTAAAACTTTTGATAAATATTTTATGAGACTTCAGGTGGGGCTGATACCTAACATATATGGATGGCATTGCTGCTTGTATTGCTAGTTTTTTCCTTTGGCTC...
pathogenic
311,469
Is the genetic variant on chromosome 20, position 10407737, gene MKKS (MKKS centrosomal shuttling protein), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
TAAAGAGTAATAAAAACATTGAAAACACATACAAAGCAATTAATATAAAATGTTTCAGAAAAATAAGATACTGAAATCAAAATCTTATTCCTAAAGTAATTACTTACTTTCATTTAATTTGGGGTCTGGCACAATGCTAACGGGCTTGTATGGGTCAGCCGGCCGGGTTGCAAACCCTTAACTAGGTTGGTTATAGTAAAAATGTATTAAAAATGTATATACTACCAGTCATGTTACCAGAATGAGTGAATCAGAATAACCCCACCATCAGCTTATTCTGAATGAGGCTTGGTAGTGCCTCCTTAATACATGAAGGACTA...
TAAAGAGTAATAAAAACATTGAAAACACATACAAAGCAATTAATATAAAATGTTTCAGAAAAATAAGATACTGAAATCAAAATCTTATTCCTAAAGTAATTACTTACTTTCATTTAATTTGGGGTCTGGCACAATGCTAACGGGCTTGTATGGGTCAGCCGGCCGGGTTGCAAACCCTTAACTAGGTTGGTTATAGTAAAAATGTATTAAAAATGTATATACTACCAGTCATGTTACCAGAATGAGTGAATCAGAATAACCCCACCATCAGCTTATTCTGAATGAGGCTTGGTAGTGCCTCCTTAATACATGAAGGACTA...
benign
311,471
The genetic variant at chromosome 20, position 10412548, affecting gene MKKS (MKKS centrosomal shuttling protein): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
GTGTGCCTGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTT...
GTGTGCCTGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTT...
pathogenic
311,480
Considering the variant on chromosome 20, location 10412554, involving gene MKKS (MKKS centrosomal shuttling protein), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CTGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGC...
CTGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGC...
pathogenic
311,481
Considering the variant on chromosome 20, location 10412555, involving gene MKKS (MKKS centrosomal shuttling protein), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Bardet-Biedl_syndrome', 'McKusick-Kaufman_syndrome', 'Multicystic_kidney_dysplasia', 'Polycystic_kidney_disease']
TGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCG...
TGTAGTTCCAGCTACTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCG...
pathogenic
311,482
A genetic variant on chromosome 20, position 10412569, affects the gene MKKS (MKKS centrosomal shuttling protein). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTA...
CTAGGGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTA...
pathogenic
311,483
Gene mutation in MKKS (MKKS centrosomal shuttling protein) at chromosome 20, position 10412573—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
GGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTT...
GGAGGCTGAGACAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTT...
pathogenic
311,484
Clinical impact (benign or pathogenic) of the variant at chromosome 20, location 10412629, gene MKKS (MKKS centrosomal shuttling protein): what disease(s) if pathogenic?
pathogenic; ['Bardet-Biedl_syndrome', 'McKusick-Kaufman_syndrome']
TTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGC...
TTGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGC...
pathogenic
311,485
Assess the variant on chromosome 20, position 10412647, impacting MKKS (MKKS centrosomal shuttling protein): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
GCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCAT...
GCCTGGGCGATAGAGTGAGACTCCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCAT...
pathogenic
311,486
Variant on chromosome 20, at position 10412669, affecting MKKS (MKKS centrosomal shuttling protein): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Bardet-Biedl_syndrome_6', 'Inborn_genetic_diseases']
CCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCT...
CCACCTTAAAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCT...
pathogenic
311,487
A genetic variant on chromosome 20, position 10412677, affects the gene MKKS (MKKS centrosomal shuttling protein). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'MKKS-related_disorder', 'McKusick-Kaufman_syndrome', 'Retinal_dystrophy']
AAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCTAGTGTGGA...
AAACAAACAAAAACCTCTGTAAGCTGCAATATGCTTCACATGTGGCACCCATCCACAGTAACACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCTAGTGTGGA...
pathogenic
311,488
Evaluate the clinical significance of the mutation at chromosome 20, position 10412739 in gene MKKS (MKKS centrosomal shuttling protein): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Bardet-Biedl_syndrome_6', 'Retinal_dystrophy']
ACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCTAGTGTGGAAACCCAGCCCCCAGTTACAATATGGTTTCTACGGGAAAATGTTTGGTTTTTTTTTTTTTGAT...
ACCCACTACACAACCTATATCATTAATAAACAGGAATTTTGTTTGAAGGCCTGAAATGAGGTAATGTTAACTTAGATTACCAGGGGAGATAGGTAAGGCCAAAAACATACTTCATCTACCTAAAAGTTTACCTGCGCTATGTGCCTGGTAGTTTTCCCCCTTTTCTTTTTTTCTCAAAAGCTCTCTGCTCCCAAGATCCAGGACTAAAGCTATGGCTATTAATGCCATGTTTAGGTATATATTATGGGCTAGTGTGGAAACCCAGCCCCCAGTTACAATATGGTTTCTACGGGAAAATGTTTGGTTTTTTTTTTTTTGAT...
pathogenic
311,491
Located at chromosome 20 position 10412998, the variant affecting gene MKKS (MKKS centrosomal shuttling protein)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
ACCCAGCCCCCAGTTACAATATGGTTTCTACGGGAAAATGTTTGGTTTTTTTTTTTTTGATAGGGAATCTTGCTGTCACCAGGCTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGA...
ACCCAGCCCCCAGTTACAATATGGTTTCTACGGGAAAATGTTTGGTTTTTTTTTTTTTGATAGGGAATCTTGCTGTCACCAGGCTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGA...
pathogenic
311,494
Variant in gene MKKS (MKKS centrosomal shuttling protein), located at chromosome 20 position 10413079: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
GGCTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGT...
GGCTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGT...
pathogenic
311,495
A genetic alteration at chromosome 20, position 10413081, in gene MKKS (MKKS centrosomal shuttling protein)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAA...
CTGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAA...
pathogenic
311,496
Is the chromosome 20, position 10413082 variant in MKKS (MKKS centrosomal shuttling protein) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
TGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAAT...
TGGAGTGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAAT...
pathogenic
311,497
Variant chromosome 20, position 10413134, gene MKKS (MKKS centrosomal shuttling protein): benign or pathogenic? Disease(s)?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'MKKS-related_disorder', 'McKusick-Kaufman_syndrome']
AAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCC...
AAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCC...
pathogenic
311,500
Regarding the variant found on chromosome 20 at position 10413166 in gene MKKS (MKKS centrosomal shuttling protein): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
CTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTC...
CTGGGATTACAAGTGCGGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTC...
pathogenic
311,501
Gene MKKS (MKKS centrosomal shuttling protein) variant at chromosome position 10413233 on chromosome 20: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'McKusick-Kaufman_syndrome']
ACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTCTGGAAGACCCAGTATTCACAAACTGGAAATTGCCAGATTCATGCAAAGCTAGTAGATATTTAAGGCT...
ACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTCTGGAAGACCCAGTATTCACAAACTGGAAATTGCCAGATTCATGCAAAGCTAGTAGATATTTAAGGCT...
pathogenic
311,502
Chromosome 20, position 10413262, gene MKKS (MKKS centrosomal shuttling protein): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Bardet-Biedl_syndrome', 'Bardet-Biedl_syndrome_6', 'Inborn_genetic_diseases', 'McKusick-Kaufman_syndrome']
CTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTCTGGAAGACCCAGTATTCACAAACTGGAAATTGCCAGATTCATGCAAAGCTAGTAGATATTTAAGGCTATCAGTCTGACTTACCATACCAACAACGA...
CTGACCTTGTGATCCGCTCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCCAGCCCTTTCTGTTTTTTTAGATGTAGTCCTGCTTTGTTGCCCAGGCTGGACTTGAACTCCTTGGCTCAAGTAATCCTCCTGCCTCAACTTCCCAGGTAGCTGGGACTACAGGCATGTACCACACCCAGCTAAAGTGTCCCATATTTTAAAAATGAGTCTGGAAGACCCAGTATTCACAAACTGGAAATTGCCAGATTCATGCAAAGCTAGTAGATATTTAAGGCTATCAGTCTGACTTACCATACCAACAACGA...
pathogenic
311,504