question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Mutation at chromosome 21, position 33551477, within SON (SON DNA and RNA binding protein): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
CTCTACTTTGGGGAATGTCTGACAAAATTAATTTCTATTACTTTTAGACTTGAAAGAGGGCTCCAGAAAAAGTAGATGCGTATCTGTACAAACAGATCCTACTGATGAAATTCCCACTAAAAAGTCAAAGAAGCATAAAAAGCACAAAAACAAAAAGAAGAAAAAGAAGAAAGAAAAGGAAAAAAAATATAAAAGACAGCCAGAAGAATCTGAGTCAAAGACGAAATCTCATGATGATGGGAACATAGATTTAGAATCTGATTCCTTTTTAAAGTTTGATTCTGAACCTTCAGCTGTGGCGCTGGAGCTTCCTACAAGAG...
CTCTACTTTGGGGAATGTCTGACAAAATTAATTTCTATTACTTTTAGACTTGAAAGAGGGCTCCAGAAAAAGTAGATGCGTATCTGTACAAACAGATCCTACTGATGAAATTCCCACTAAAAAGTCAAAGAAGCATAAAAAGCACAAAAACAAAAAGAAGAAAAAGAAGAAAGAAAAGGAAAAAAAATATAAAAGACAGCCAGAAGAATCTGAGTCAAAGACGAAATCTCATGATGATGGGAACATAGATTTAGAATCTGATTCCTTTTTAAAGTTTGATTCTGAACCTTCAGCTGTGGCGCTGGAGCTTCCTACAAGAG...
benign
317,724
A genetic alteration at chromosome 21, position 33552303, in gene SON (SON DNA and RNA binding protein)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Failure_to_thrive', 'Global_developmental_delay', 'ZTTK_syndrome']
CAGCCTGTAGACGTACCATCGGAGATTGCAGATTCATCCATGACAAGACCGCAGGAGTTGCCGGAGCTGCCTAAGACCACAGCGTTGGAGCTGCAGGAGTCGTCGGTGGCCTCAGCGATGGAGTTGCCGGGGCCACCTGCGACCTCCATGCCGGAGTTGCAGGGGCCCCCTGTGACTCCAGTGCTGGAGTTACCTGGGCCCTCTGCTACCCCGGTGCCAGAGTTGCCAGGGCCCCTTTCTACCCCAGTGCCTGAGTTGCCAGGGCCCCCTGCGACAGCAGTGCCTGAGTTGCCAGGGCCCTCTGTGACACCAGTGCCACA...
CAGCCTGTAGACGTACCATCGGAGATTGCAGATTCATCCATGACAAGACCGCAGGAGTTGCCGGAGCTGCCTAAGACCACAGCGTTGGAGCTGCAGGAGTCGTCGGTGGCCTCAGCGATGGAGTTGCCGGGGCCACCTGCGACCTCCATGCCGGAGTTGCAGGGGCCCCCTGTGACTCCAGTGCTGGAGTTACCTGGGCCCTCTGCTACCCCGGTGCCAGAGTTGCCAGGGCCCCTTTCTACCCCAGTGCCTGAGTTGCCAGGGCCCCCTGCGACAGCAGTGCCTGAGTTGCCAGGGCCCTCTGTGACACCAGTGCCACA...
pathogenic
317,740
The mutation impacting SON (SON DNA and RNA binding protein) on chromosome 21 at position 33552321: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
TCGGAGATTGCAGATTCATCCATGACAAGACCGCAGGAGTTGCCGGAGCTGCCTAAGACCACAGCGTTGGAGCTGCAGGAGTCGTCGGTGGCCTCAGCGATGGAGTTGCCGGGGCCACCTGCGACCTCCATGCCGGAGTTGCAGGGGCCCCCTGTGACTCCAGTGCTGGAGTTACCTGGGCCCTCTGCTACCCCGGTGCCAGAGTTGCCAGGGCCCCTTTCTACCCCAGTGCCTGAGTTGCCAGGGCCCCCTGCGACAGCAGTGCCTGAGTTGCCAGGGCCCTCTGTGACACCAGTGCCACAGTTGTCGCAGGAATTGCC...
TCGGAGATTGCAGATTCATCCATGACAAGACCGCAGGAGTTGCCGGAGCTGCCTAAGACCACAGCGTTGGAGCTGCAGGAGTCGTCGGTGGCCTCAGCGATGGAGTTGCCGGGGCCACCTGCGACCTCCATGCCGGAGTTGCAGGGGCCCCCTGTGACTCCAGTGCTGGAGTTACCTGGGCCCTCTGCTACCCCGGTGCCAGAGTTGCCAGGGCCCCTTTCTACCCCAGTGCCTGAGTTGCCAGGGCCCCCTGCGACAGCAGTGCCTGAGTTGCCAGGGCCCTCTGTGACACCAGTGCCACAGTTGTCGCAGGAATTGCC...
benign
317,741
Determine whether the variant at chromosome 21, position 33552917, in gene SON (SON DNA and RNA binding protein) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
GGAGTTGCCAGGACAGCCAGTGGCAACGACAGCGCTGGAGTTGCCGGGGCAGCCTTCGGTGACTGGGGTGCCAGAGTTGCCAGGGCTGCCTTCGGCAACTAGGGCACTGGAGTTGTCGGGGCAGCCTGTGGCAACTGGGGCACTAGAGTTGCCTGGGCCGCTCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGA...
GGAGTTGCCAGGACAGCCAGTGGCAACGACAGCGCTGGAGTTGCCGGGGCAGCCTTCGGTGACTGGGGTGCCAGAGTTGCCAGGGCTGCCTTCGGCAACTAGGGCACTGGAGTTGTCGGGGCAGCCTGTGGCAACTGGGGCACTAGAGTTGCCTGGGCCGCTCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGA...
benign
317,755
Mutation found at chromosome 21 position 33553037, gene SON (SON DNA and RNA binding protein): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GCAGCCTGTGGCAACTGGGGCACTAGAGTTGCCTGGGCCGCTCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGATCTCTGTTCAGTCTGTGGTGACAACATCGGAGCTGTCAACGATGACCGTGTCGCAGTCCCTGGAGGTGCCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTA...
GCAGCCTGTGGCAACTGGGGCACTAGAGTTGCCTGGGCCGCTCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGATCTCTGTTCAGTCTGTGGTGACAACATCGGAGCTGTCAACGATGACCGTGTCGCAGTCCCTGGAGGTGCCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTA...
benign
317,759
Mutation at chromosome 21, position 33553078, within SON (SON DNA and RNA binding protein): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Failure_to_thrive', 'Global_developmental_delay', 'ZTTK_syndrome']
TCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGATCTCTGTTCAGTCTGTGGTGACAACATCGGAGCTGTCAACGATGACCGTGTCGCAGTCCCTGGAGGTGCCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGAT...
TCATGGCAGCTGGGGCACTGGAGTTCTCGGGGCAGTCTGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCTCTGGCAACAGGGGTGCTGGAGTTGCCAGGGCAGCCTGGGGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGATCTCTGTTCAGTCTGTGGTGACAACATCGGAGCTGTCAACGATGACCGTGTCGCAGTCCCTGGAGGTGCCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGAT...
pathogenic
317,760
Considering the genetic mutation at chromosome 21, position 33553305, impacting SON (SON DNA and RNA binding protein): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
CCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGA...
CCCTCGACGACAGCGCTGGAATCCTATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGA...
benign
317,765
Clinical impact (benign or pathogenic) of the variant at chromosome 21, location 33553329, gene SON (SON DNA and RNA binding protein): what disease(s) if pathogenic?
benign
TATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCAC...
TATAATACGGTAGCACAGGAGCTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCAC...
benign
317,766
Evaluate if the mutation on chromosome 21 at position 33553350 in SON (SON DNA and RNA binding protein) is benign or pathogenic. Disease name(s) if pathogenic?
benign
CTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCACTATGGACTCCCAGATGTTAGC...
CTGCCTACTACATTAGTGGGGGAGACTTCTGTAACAGTAGGAGTGGATCCCTTGATGGCCCCAGAATCCCATATATTAGCTTCTAACACCATGGAGACCCATATATTAGCATCCAACACCATGGACTCCCAAATGCTAGCGTCCAACACCATGGACTCCCAGATGCTAGCATCCAACACCATGGACTCCCAGATGTTAGCGTCTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCTCCATGGACTCCCAGATGTTAGCAACTAGCACTATGGACTCCCAGATGTTAGC...
benign
317,768
Clinical significance of chromosome 21, position 33554005, gene SON (SON DNA and RNA binding protein): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Inborn_genetic_diseases']
AATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGATCCCTATAGGTTGGGCCATGACCCCTATAGATTAGGTCATGATGCTTACAGGTTAGGACAAGACCCTTATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCTATGATGATGTCCTATGCTGCAGAACGTTCCATGATGTCATCTTACGAACGC...
AATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGATCCCTATAGGTTGGGCCATGACCCCTATAGATTAGGTCATGATGCTTACAGGTTAGGACAAGACCCTTATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCTATGATGATGTCCTATGCTGCAGAACGTTCCATGATGTCATCTTACGAACGC...
pathogenic
317,784
A genetic variant at chromosome 21, position 33554125, affecting gene SON (SON DNA and RNA binding protein)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['ZTTK_syndrome']
ATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCTATGATGATGTCCTATGCTGCAGAACGTTCCATGATGTCATCTTACGAACGCTCTATGATGTCTTATGAGCGGTCTATGATGTCCCCTATGGCTGAACGCTCTATGATGTCAGCCTACGAGCGCTCTATGATGTCAGCCTACGAGCGCTCTATGATGTCCCCTATGGCTGAG...
ATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCTATGATGATGTCCTATGCTGCAGAACGTTCCATGATGTCATCTTACGAACGCTCTATGATGTCTTATGAGCGGTCTATGATGTCCCCTATGGCTGAACGCTCTATGATGTCAGCCTACGAGCGCTCTATGATGTCAGCCTACGAGCGCTCTATGATGTCCCCTATGGCTGAG...
pathogenic
317,788
Clinical classification of chromosome 21, position 33554891, gene SON (SON DNA and RNA binding protein): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; [, 'ZTTK_syndrome']
TGAAGAGTCTGTATCGCAGCCTGAGCCTCCTGTGAGTCAAAGTGAGATTTCGGAGCCTTCAGCAGTGCCTACTGATTATTCAGTGTCAGCATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAA...
TGAAGAGTCTGTATCGCAGCCTGAGCCTCCTGTGAGTCAAAGTGAGATTTCGGAGCCTTCAGCAGTGCCTACTGATTATTCAGTGTCAGCATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAA...
pathogenic
317,799
Does the genetic variant at chromosome 21, position 33554944, impacting gene SON (SON DNA and RNA binding protein), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Inborn_genetic_diseases', 'ZTTK_syndrome']
AGCCTTCAGCAGTGCCTACTGATTATTCAGTGTCAGCATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCC...
AGCCTTCAGCAGTGCCTACTGATTATTCAGTGTCAGCATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCC...
pathogenic
317,800
Variant at chromosome 21, position 33554981, gene SON (SON DNA and RNA binding protein): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Failure_to_thrive', 'Global_developmental_delay', 'Hereditary_spastic_paraplegia_17', 'Inborn_genetic_diseases', 'Neurodevelopmental_abnormality', 'ZTTK_syndrome']
ATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAG...
ATCAGATCCCTCAGTTTTAGTATCAGAGGCTGCTGTGACTGTTCCAGAACCACCACCAGAGCCAGAATCTTCAATTACGTTAACACCTGTAGAGTCTGCAGTAGTAGCAGAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAG...
pathogenic
317,801
Does the chromosome 21 mutation at position 33555090 within gene SON (SON DNA and RNA binding protein) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
GAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGA...
GAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGA...
benign
317,804
Does the variant impacting SON (SON DNA and RNA binding protein) on chromosome 21, position 33555090, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
GAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGA...
GAAGAACATGAAGTTGTTCCAGAGAGACCAGTGACTTGTATGGTATCTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGA...
benign
317,805
Determine if the mutation at chromosome 21, position 33555136 in gene SON (SON DNA and RNA binding protein) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
CTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGAGTCTTCGACTGTAACTGTCCTGGAGCCTTCGGTTGTGACTGTCCCG...
CTGAAACTCCCGCCATGTCAGCTGAACCAACTGTGTTAGCATCAGAGCCTCCTGTTATGTCAGAGACAGCAGAAACATTTGATTCCATGAGAGCCTCAGGACATGTTGCCTCAGAAGTATCTACATCCTTGTTGGTTCCAGCAGTAACTACTCCAGTGCTGGCAGAGAGCATTCTGGAGCCGCCAGCCATGGCTGCCCCAGAGTCTTCAGCTATGGCTGTCCTGGAGTCTTCGGCTGTGACCGTCCTGGAGTCTTCGACTGTGACTGTCCTGGAGTCTTCGACTGTAACTGTCCTGGAGCCTTCGGTTGTGACTGTCCCG...
benign
317,808
A genetic alteration at chromosome 21, position 33576378, in gene SON (SON DNA and RNA binding protein)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
TTTGGAAATGAACTAGCTCTGCACCAAATACTTTGATGTTAAGTATTGTACAATTTCAGGAAGCATTGTCCTTGGAATTGTGGGACATGGCCTGACTGTAAGCTCTCAGAGAACCACAGATTTCCCAGGATAGGTTTAGAAAAGCTTATATTAGCATGGAATTATTTAGCAAAGGTTGAAAAATTTCCTGTAACATACAGGATGAGCATCCCACATCTGGAAACCTGAAATGCTTTAAAACAGAAAACTTTTTGAATACTGATATGATGCTCAAAGGAAATACTCATTGGTGCATTTTGGATTTCAGCCTCTTCAGATTT...
TTTGGAAATGAACTAGCTCTGCACCAAATACTTTGATGTTAAGTATTGTACAATTTCAGGAAGCATTGTCCTTGGAATTGTGGGACATGGCCTGACTGTAAGCTCTCAGAGAACCACAGATTTCCCAGGATAGGTTTAGAAAAGCTTATATTAGCATGGAATTATTTAGCAAAGGTTGAAAAATTTCCTGTAACATACAGGATGAGCATCCCACATCTGGAAACCTGAAATGCTTTAAAACAGAAAACTTTTTGAATACTGATATGATGCTCAAAGGAAATACTCATTGGTGCATTTTGGATTTCAGCCTCTTCAGATTT...
benign
317,822
Does the variant on chromosome 21 at location 33579437 affecting gene DONSON (DNA replication fork stabilization factor DONSON) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic
ATTTCATGTGTATTACAGTGGTATTCATATGCTATGTCTCTAAACTTTATTTTCAAAAGCTTAAGGCCCAAATACAAACTTCTCTGGAATAAACGTGGTGTTTTATTTTCTGGGTTATAAAGTGAACAAATACTTAGATACTATTATTTCTTTACCCAATGCTTTTGATTTTTAAGCACTTTTATTTTAAAAATGTGAATTATACAGTCCCCCCCTACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACCCCTAT...
ATTTCATGTGTATTACAGTGGTATTCATATGCTATGTCTCTAAACTTTATTTTCAAAAGCTTAAGGCCCAAATACAAACTTCTCTGGAATAAACGTGGTGTTTTATTTTCTGGGTTATAAAGTGAACAAATACTTAGATACTATTATTTCTTTACCCAATGCTTTTGATTTTTAAGCACTTTTATTTTAAAAATGTGAATTATACAGTCCCCCCCTACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACCCCTAT...
pathogenic
317,828
Is the genetic change at chromosome 21, position 33581397, within gene DONSON (DNA replication fork stabilization factor DONSON) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Inborn_genetic_diseases', 'Microcephaly,_short_stature,_and_limb_abnormalities']
CCATATCAAGTACTTTGTCCATTTGCAGGCAGATGTTAAATACAGCAGTTGGCTCGTGTGGATACAGTACTGCAGAGAAAGATCCACTCTGTGAAGATTTGAGCAGCATGGTCAGTGAATGCAGAGAATGAGGCATGATAGGACCTGTAATCTCCAAACTAAATTGGTCTCTGTATCCAGAAAGAGCTTGTGTCTTCACATTCACACTCCGTGCCTTCATGAAAATGTAAAGAAAAGGAAAATTAAGATCATCTCTCAACCTTTTGCCTAGCCAAAAATATGTTCAATATATTTCCATTTGGGGTTTCCTCTCTTTTAAC...
CCATATCAAGTACTTTGTCCATTTGCAGGCAGATGTTAAATACAGCAGTTGGCTCGTGTGGATACAGTACTGCAGAGAAAGATCCACTCTGTGAAGATTTGAGCAGCATGGTCAGTGAATGCAGAGAATGAGGCATGATAGGACCTGTAATCTCCAAACTAAATTGGTCTCTGTATCCAGAAAGAGCTTGTGTCTTCACATTCACACTCCGTGCCTTCATGAAAATGTAAAGAAAAGGAAAATTAAGATCATCTCTCAACCTTTTGCCTAGCCAAAAATATGTTCAATATATTTCCATTTGGGGTTTCCTCTCTTTTAAC...
pathogenic
317,834
Is the genetic change at chromosome 21, position 33588593, within gene DONSON (DNA replication fork stabilization factor DONSON) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Meier-Gorlin_syndrome_1']
ACAAAGCCCATATTTAAGAAACATTTCCTGACTTCAAATATTTCCCCTCAACCTGTCTGCTTCAGGTCGACGTTCTCCACAATACAAGAATTTTTTTTTTTTTAAATTGAGACGGAGTCTCCCTCTGTCGCCTAGGCTGAGTGAAGTGGTGTGATCTCGGCTCAGTACCAACCTCTGCCGCCTAGGATCAAGCGATTCTCGTGCCTCGTCCTCCCGAGTACCTGGGACTACAGGCGTGCCCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTCGAGACGGGGGTTTCGTCATATTGGCCAGGCTGTTCGCGAACTCC...
ACAAAGCCCATATTTAAGAAACATTTCCTGACTTCAAATATTTCCCCTCAACCTGTCTGCTTCAGGTCGACGTTCTCCACAATACAAGAATTTTTTTTTTTTTAAATTGAGACGGAGTCTCCCTCTGTCGCCTAGGCTGAGTGAAGTGGTGTGATCTCGGCTCAGTACCAACCTCTGCCGCCTAGGATCAAGCGATTCTCGTGCCTCGTCCTCCCGAGTACCTGGGACTACAGGCGTGCCCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTCGAGACGGGGGTTTCGTCATATTGGCCAGGCTGTTCGCGAACTCC...
pathogenic
317,846
Evaluate if the mutation on chromosome 21 at position 34447697 in KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) is benign or pathogenic. Disease name(s) if pathogenic?
benign
GTCTAGATGGTGCCCACATTCCCTGCTCTGTCTAGATGGTGCCGACATACCCTGATCTGTCCAGACAGTGCCTACATTCCCTGCTCCATCTGGATGGTGCCCACATTCCCTGCTCTGTCCAGACGGTGCCCACATTCCCTGCTCTGTCTGGACGGTGCCCACATTCCCTGATCTGTCCGGACAGTGCCCACATTCCCTCCTCCGTCCGGAAGGTGCCCACATTCCCTGCTGTGTCTGGACGGTGCCCACATTTCCTGCTCCGTCCAGACAGTGCCCACATTCCCTGCTGTGTCTAGATGGTGCCCACATTCCCTGCTCCG...
GTCTAGATGGTGCCCACATTCCCTGCTCTGTCTAGATGGTGCCGACATACCCTGATCTGTCCAGACAGTGCCTACATTCCCTGCTCCATCTGGATGGTGCCCACATTCCCTGCTCTGTCCAGACGGTGCCCACATTCCCTGCTCTGTCTGGACGGTGCCCACATTCCCTGATCTGTCCGGACAGTGCCCACATTCCCTCCTCCGTCCGGAAGGTGCCCACATTCCCTGCTGTGTCTGGACGGTGCCCACATTTCCTGCTCCGTCCAGACAGTGCCCACATTCCCTGCTGTGTCTAGATGGTGCCCACATTCCCTGCTCCG...
benign
317,910
Gene KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) variant at chromosome position 34448015 on chromosome 21: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
CGTCCAGACAGTGCCCACATTCCCTGCTCTGTCTAGATGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCCATCCGGACGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCTGTCCAGATGGTGCCCACATTCCCTGCTCCATCTGGACGGTGCCCACATTCCCTCCTCTGTCTAGACAGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCTGTCTGGACGGTGCTCACATTCCCTGCTCT...
CGTCCAGACAGTGCCCACATTCCCTGCTCTGTCTAGATGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCCATCCGGACGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCTGTCCAGATGGTGCCCACATTCCCTGCTCCATCTGGACGGTGCCCACATTCCCTCCTCTGTCTAGACAGTGCCCACATTCCCTGCTCCGTCCGGACGGTGCCCACATTCCCTGCTCTGTCTGGACGGTGCTCACATTCCCTGCTCT...
benign
317,912
Determine if the mutation at chromosome 21, position 34449406 in gene KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Long_QT_syndrome']
TCAGAGGACTTTGTAACCCAAAGAACCACTCATCTCAAGGACTGTGGTAACTCAGGGGCTGAGCCATGCCAGTGTTTATTATGTGAAACAAGGACTGGAACCTCACAAGACCAAGTCTGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCC...
TCAGAGGACTTTGTAACCCAAAGAACCACTCATCTCAAGGACTGTGGTAACTCAGGGGCTGAGCCATGCCAGTGTTTATTATGTGAAACAAGGACTGGAACCTCACAAGACCAAGTCTGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCC...
pathogenic
317,929
Gene mutation in KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) at chromosome 21, position 34449458—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Jervell_and_Lange-Nielsen_syndrome_2', 'Long_QT_syndrome', 'Long_QT_syndrome_5']
CAGGGGCTGAGCCATGCCAGTGTTTATTATGTGAAACAAGGACTGGAACCTCACAAGACCAAGTCTGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAG...
CAGGGGCTGAGCCATGCCAGTGTTTATTATGTGAAACAAGGACTGGAACCTCACAAGACCAAGTCTGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAG...
pathogenic
317,932
Determine whether the variant at chromosome 21, position 34449523, in gene KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
TGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAGCTCCATCTCTGGGTGGGTGAGAGGTGCTGCATGGGCTCACTATAGTATCCCAATACTGTATGGCA...
TGTCCATTTGAGGATGGCCCAAGATGCACACGGGCTGCTTTTATCTTATGCGCAGGTTTTAAAAAAATATGTTTCATTTAAATATTCCATACTCTTCAGGAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAGCTCCATCTCTGGGTGGGTGAGAGGTGCTGCATGGGCTCACTATAGTATCCCAATACTGTATGGCA...
benign
317,939
Gene mutation in KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) at chromosome 21, position 34449622—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Cardiovascular_phenotype', 'Jervell_and_Lange-Nielsen_syndrome_2', 'Long_QT_syndrome', 'Long_QT_syndrome_5']
GAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAGCTCCATCTCTGGGTGGGTGAGAGGTGCTGCATGGGCTCACTATAGTATCCCAATACTGTATGGCAGTAGGCTGCCAGAGTATCCTAAGCTGGGTGGCTTCAACAACAGGTACTGACTCACAGTTCTGGAGGCCAAAAGTTTGAATTCAAGCAGGGCTGTGCTTC...
GAATGCCCAGGCAGCTGAGCTTTCAGGATGTCGCATTGCAGAGGACTCCAATGCTACATATGGCAGCTGGAGACCCTTTCAAGGCAGGTGGCAGAACGGAGGCCCTCTCTATCTGCTGGGGCAGCCCTCCGGGTGCCCCGCTGGAAGGCAGAGCAGCTCCATCTCTGGGTGGGTGAGAGGTGCTGCATGGGCTCACTATAGTATCCCAATACTGTATGGCAGTAGGCTGCCAGAGTATCCTAAGCTGGGTGGCTTCAACAACAGGTACTGACTCACAGTTCTGGAGGCCAAAAGTTTGAATTCAAGCAGGGCTGTGCTTC...
pathogenic
317,943
The genetic variant at chromosome 21, position 34789584, affecting gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease name(s) if pathogenic?
benign
AGCCACCGCGCCGGCCTATTATTATTTTTTAAAACAAGCATTAAAACATGCTTCAGTGCTCTTTCATATGCAAAGAAGCAACCCTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACAC...
AGCCACCGCGCCGGCCTATTATTATTTTTTAAAACAAGCATTAAAACATGCTTCAGTGCTCTTTCATATGCAAAGAAGCAACCCTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACAC...
benign
318,001
Clinical significance of chromosome 21, position 34789604, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Name the disease(s) if pathogenic.
benign
ATTATTTTTTAAAACAAGCATTAAAACATGCTTCAGTGCTCTTTCATATGCAAAGAAGCAACCCTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACACTGGATTTACAGAAGAAACTG...
ATTATTTTTTAAAACAAGCATTAAAACATGCTTCAGTGCTCTTTCATATGCAAAGAAGCAACCCTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACACTGGATTTACAGAAGAAACTG...
benign
318,004
Considering the genetic mutation at chromosome 21, position 34789667, impacting RUNX1 (RUNX family transcription factor 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
CTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACACTGGATTTACAGAAGAAACTGTGGTACAAAGAGAGGAAGGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAG...
CTGGGAGCCTGCGCCTTTTCCAGGCCCTCATGCCTTCAGAAGCCAGAGTGTGCTAGGAGCACCGGGGGTGAGGACATAGCTTCAGCCTGAAGCTGTTCACTGGAGGTATCTTCCTAGTGTGTGCAGTGGGCCTTACTCAGTTTCCCAACCCTCCATCTCAGAGAAAGACAAAACCAATTGGATATGGTGTATGTACTTGTCAAACTGTTTATTTGCCATTCACACTGATTGTAACACTGGATTTACAGAAGAAACTGTGGTACAAAGAGAGGAAGGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAG...
benign
318,006
Is the chromosome 21, position 34789933 variant in RUNX1 (RUNX family transcription factor 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
GAGAGGAAGGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAGGCTGGGCACGACGAATGCTCCCAGGAGAGGGGAGGCGGCCCACCCGACTGTGTACCGTGGACTGTGGACAGTGCAGTGCCTGCTCTCCTGTGCTATCTAGAAACACCTTGGAGAGAGGGTTCTGGGATATTCTCTCATGTCATCTGGCTGAAGACACCAGCTTGACAGTTCCCCTTTAAGAAGCATTCCATACGTTTGTACCAGGGAGAAAGAAGCCCACGCACGAATTTTCAGGATGTTTTGTGACCAAACCCAATAACTGCCAC...
GAGAGGAAGGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAGGCTGGGCACGACGAATGCTCCCAGGAGAGGGGAGGCGGCCCACCCGACTGTGTACCGTGGACTGTGGACAGTGCAGTGCCTGCTCTCCTGTGCTATCTAGAAACACCTTGGAGAGAGGGTTCTGGGATATTCTCTCATGTCATCTGGCTGAAGACACCAGCTTGACAGTTCCCCTTTAAGAAGCATTCCATACGTTTGTACCAGGGAGAAAGAAGCCCACGCACGAATTTTCAGGATGTTTTGTGACCAAACCCAATAACTGCCAC...
benign
318,011
Gene mutation in RUNX1 (RUNX family transcription factor 1) at chromosome 21, position 34789941—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
GGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAGGCTGGGCACGACGAATGCTCCCAGGAGAGGGGAGGCGGCCCACCCGACTGTGTACCGTGGACTGTGGACAGTGCAGTGCCTGCTCTCCTGTGCTATCTAGAAACACCTTGGAGAGAGGGTTCTGGGATATTCTCTCATGTCATCTGGCTGAAGACACCAGCTTGACAGTTCCCCTTTAAGAAGCATTCCATACGTTTGTACCAGGGAGAAAGAAGCCCACGCACGAATTTTCAGGATGTTTTGTGACCAAACCCAATAACTGCCACACAAATAG...
GGCTCTGGTGGCTCCTGAACAGCAGCAGTCCAGCTGCCCTGCTCAGGCTGGGCACGACGAATGCTCCCAGGAGAGGGGAGGCGGCCCACCCGACTGTGTACCGTGGACTGTGGACAGTGCAGTGCCTGCTCTCCTGTGCTATCTAGAAACACCTTGGAGAGAGGGTTCTGGGATATTCTCTCATGTCATCTGGCTGAAGACACCAGCTTGACAGTTCCCCTTTAAGAAGCATTCCATACGTTTGTACCAGGGAGAAAGAAGCCCACGCACGAATTTTCAGGATGTTTTGTGACCAAACCCAATAACTGCCACACAAATAG...
benign
318,013
Variant at chromosome 21, position 34790450, gene RUNX1 (RUNX family transcription factor 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
ACTTAAAAAAAATTGGAACCATGCTATTAGCTGTTTACAAAAGTGAATAAGAAGTAGCTCATTTTAAAGTCTAAAATAAACAAAGTAGAAAGAAGCATTTTTTTCCCTACAGTATTTAGCAAACCTAAGAAAAAGTCCTTAGAAACACACACAAAAAAATTGAAAAAAAGTTATAGGCATTAACAATATTTTATAATGAAGCTTAAAATCTATTTACATACATAAATACAATTAACTTTGTTGATGCAACTCTTCTGGAAGGAAAAAAAGAGCCAAATGATCAGCCTCATCAATACTGACCTGGCTAAAAACAAAATTCC...
ACTTAAAAAAAATTGGAACCATGCTATTAGCTGTTTACAAAAGTGAATAAGAAGTAGCTCATTTTAAAGTCTAAAATAAACAAAGTAGAAAGAAGCATTTTTTTCCCTACAGTATTTAGCAAACCTAAGAAAAAGTCCTTAGAAACACACACAAAAAAATTGAAAAAAAGTTATAGGCATTAACAATATTTTATAATGAAGCTTAAAATCTATTTACATACATAAATACAATTAACTTTGTTGATGCAACTCTTCTGGAAGGAAAAAAAGAGCCAAATGATCAGCCTCATCAATACTGACCTGGCTAAAAACAAAATTCC...
benign
318,019
The mutation impacting RUNX1 (RUNX family transcription factor 1) on chromosome 21 at position 34791217: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
AACCATGTTCCTTTATGTGAAGGGGGAAGAACTGGACCTTCTTGTGTTCTGAAATTTGGTACTGGGTGGGGGTATGTGCTATCTGCTTAAGAGAACACAGGAAAAGGAGGAGGGAGAAAGTGGGGTTTGGAAGATAGAGGAAGAGAGAAAAAAAGGGAGATATTGGGGGGAAGAGAGGGAGGGAAATGTATTTTCAGATAGTGAGAAAAAGAAAGAACTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACA...
AACCATGTTCCTTTATGTGAAGGGGGAAGAACTGGACCTTCTTGTGTTCTGAAATTTGGTACTGGGTGGGGGTATGTGCTATCTGCTTAAGAGAACACAGGAAAAGGAGGAGGGAGAAAGTGGGGTTTGGAAGATAGAGGAAGAGAGAAAAAAAGGGAGATATTGGGGGGAAGAGAGGGAGGGAAATGTATTTTCAGATAGTGAGAAAAAGAAAGAACTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACA...
benign
318,029
A genetic variant at chromosome 21, position 34791404, affecting gene RUNX1 (RUNX family transcription factor 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
benign
GTATTTTCAGATAGTGAGAAAAAGAAAGAACTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTT...
GTATTTTCAGATAGTGAGAAAAAGAAAGAACTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTT...
benign
318,030
Is the variant located on chromosome 21 at position 34791434, gene RUNX1 (RUNX family transcription factor 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
CTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAA...
CTGAAATATGTATCCATGTTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAA...
benign
318,031
Determine whether the variant at chromosome 21, position 34791452, in gene RUNX1 (RUNX family transcription factor 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
TTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAA...
TTGAAATCATAAATAGGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAA...
benign
318,033
Is chromosome 21, position 34791467, gene RUNX1 (RUNX family transcription factor 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
GGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAAATGACCAATCCAGTG...
GGGACATGAGTAAGCAGTAGAAATGGCTTATTCAATACTTCTCCTGGACCAGACACATGCAGTTATTACATGATTGGCTTAAGGGTCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAAATGACCAATCCAGTG...
benign
318,034
Variant at chromosome 21, position 34791552, gene RUNX1 (RUNX family transcription factor 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
TCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAAATGACCAATCCAGTGAGCCTACAATAGTGACAAGCCCCCTCCACACATGGCTTTGAGAGTAAAGGTTCAATGTAAAAGATTATCTAATCAGAGCATGAGG...
TCTCATTGATACCTTAACTTTCCTGAGGGCAATGAATAAAAAGATACCTTAATCTACCTGAAGTCAATGAATGCAATTTTTCACACACACACACACACACGCACACACACACACATACAAAAATGTGTTGCGTGAGACCTATCGCCAAAACAACTACAGTTTGATTTTTTTTGAAACAATTAAATACTATATATGCTGGTAAGAGTCTGTGAAACTCTAAATGACCAATCCAGTGAGCCTACAATAGTGACAAGCCCCCTCCACACATGGCTTTGAGAGTAAAGGTTCAATGTAAAAGATTATCTAATCAGAGCATGAGG...
benign
318,036
Is chromosome 21, position 34792144, gene RUNX1 (RUNX family transcription factor 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GTGAATATATTCTGAGTTTGTCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGG...
GTGAATATATTCTGAGTTTGTCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGG...
pathogenic
318,057
Clinical classification of chromosome 21, position 34792164, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGA...
TCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGA...
pathogenic
318,065
Is the genetic change at chromosome 21, position 34792164, within gene RUNX1 (RUNX family transcription factor 1) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGA...
TCCGAGATCTGCTATAGCTCTTCTCTAGATAAGAACGACCTGACAACATAAGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGA...
pathogenic
318,066
Is chromosome 21, position 34792214, gene RUNX1 (RUNX family transcription factor 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
AGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTG...
AGCTGCTTTACTCTTTAACTCTTACCAAAGTGCTACTGCATGTGTGTAAAACAAATAATCAATATATATATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTG...
pathogenic
318,073
Regarding the variant found on chromosome 21 at position 34792282 in gene RUNX1 (RUNX family transcription factor 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGA...
TATAAGAAAACTCAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGA...
pathogenic
318,091
For chromosome 21, position 34792294, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATT...
CAAAAACAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATT...
pathogenic
318,097
Is the chromosome 21, position 34792300 variant in RUNX1 (RUNX family transcription factor 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCC...
CAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCC...
pathogenic
318,099
Clinically, how would you classify the variant at chromosome 21, position 34792300, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCC...
CAAGTTGTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCC...
pathogenic
318,100
Is the genetic mutation found on chromosome 21 at position 34792306, within the gene RUNX1 (RUNX family transcription factor 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGAC...
GTTTTAAATAAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGAC...
pathogenic
318,108
Mutation at chromosome 21, position 34792315, within RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Atypical_chronic_myeloid_leukemia,_BCR-ABL1_negative', 'Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
AAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGAC...
AAGTCCAGCTGTTTTTGCTGCCTGCAGCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGAC...
pathogenic
318,117
Chromosome 21, position 34792341, gene RUNX1 (RUNX family transcription factor 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGC...
GCCAAAGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGC...
pathogenic
318,125
Considering the variant on chromosome 21, location 34792346, involving gene RUNX1 (RUNX family transcription factor 1), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
AGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGG...
AGATTTGCCTAATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGG...
pathogenic
318,128
The chromosome 21, position 34792357 genetic variant in gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Acute_myeloid_leukemia', 'Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
ATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCAT...
ATTTGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCAT...
pathogenic
318,133
A genetic alteration at chromosome 21, position 34792360, in gene RUNX1 (RUNX family transcription factor 1)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATA...
TGAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATA...
pathogenic
318,134
Clinically, how would you classify the variant at chromosome 21, position 34792361, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
GAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATAC...
GAATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATAC...
pathogenic
318,135
Clinical impact (benign or pathogenic) of the variant at chromosome 21, location 34792363, gene RUNX1 (RUNX family transcription factor 1): what disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
ATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCC...
ATGCTTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCC...
pathogenic
318,138
The mutation in gene RUNX1 (RUNX family transcription factor 1) at chromosome 21, position 34792367—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
TTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATA...
TTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATA...
pathogenic
318,139
Variant chromosome 21, position 34792367, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease(s)?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATA...
TTAAATTTATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATA...
pathogenic
318,140
Determine whether the variant at chromosome 21, position 34792374, in gene RUNX1 (RUNX family transcription factor 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGG...
TATAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGG...
pathogenic
318,142
For chromosome 21, position 34792376, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
TAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGT...
TAAAATAAAAATCAAACACTGTTCTGAAGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGT...
pathogenic
318,145
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 21, position 34792403, gene RUNX1 (RUNX family transcription factor 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'RUNX1-related_disorder']
AGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGA...
AGTCCTGCTTTCAAATACTCTTCAGAGTTGACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGA...
pathogenic
318,150
Assess the variant on chromosome 21, position 34792432, impacting RUNX1 (RUNX family transcription factor 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'likely other unspecified diseases']
GACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGG...
GACCTGAAATCGTTTCAACGAATTTTAAGAGGTACGTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGG...
pathogenic
318,158
Determine if the mutation at chromosome 21, position 34792467 in gene RUNX1 (RUNX family transcription factor 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTG...
GTTAAATAACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTG...
pathogenic
318,165
Does the variant impacting RUNX1 (RUNX family transcription factor 1) on chromosome 21, position 34792474, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
AACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCAC...
AACCACCAGATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCAC...
benign
318,168
Does the variant impacting RUNX1 (RUNX family transcription factor 1) on chromosome 21, position 34792483, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Myelodysplasia']
ATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACA...
ATCATTTGGAGCACACATGTGTCAAAATCAGCAGTTAGTATTTATGAGTTGTACAACAACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACA...
pathogenic
318,171
Is the genetic mutation found on chromosome 21 at position 34792541, within the gene RUNX1 (RUNX family transcription factor 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Acute_myeloid_leukemia', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
pathogenic
318,186
Assess the variant on chromosome 21, position 34792541, impacting RUNX1 (RUNX family transcription factor 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
pathogenic
318,187
Mutation at chromosome 21, position 34792541, within RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'RUNX1-related_disorder']
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
ACTGCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATC...
pathogenic
318,188
Benign or pathogenic: chromosome 21, position 34792544, gene RUNX1 (RUNX family transcription factor 1) variant? Disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTA...
GCATTCTGACCAAATCCTCCAATAAAAATAGTGCCATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTA...
pathogenic
318,189
Variant in gene RUNX1 (RUNX family transcription factor 1), located at chromosome 21 position 34792578: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
CATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAA...
CATAAAATTTACAGCGACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAA...
pathogenic
318,202
Considering the genetic mutation at chromosome 21, position 34792594, impacting RUNX1 (RUNX family transcription factor 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
ACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAATGTGGCTCCCCTACAC...
ACATTGGATACCTTTGAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAATGTGGCTCCCCTACAC...
pathogenic
318,213
Clinically, how would you classify the variant at chromosome 21, position 34792609, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
GAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAATGTGGCTCCCCTACACAGTTTACTTTGGCTG...
GAATTGTAGCCACGGACAGTAGTGACATGAATCTTTCCTGTCACACTGGTGCACAGGTAAAAGCCCATATACCCCATAGGGTAGGGTCTCAGCCTGGTGAAAGCAACACAAAGATGTTGTTGAGTGAGCAGCACAGGACAGGGGGTCTCGCACAGGTGGGACCATGTTTTCCCACTTGTCTCCACTGAGGCACACAGAGGCAAATTGACTCCTCGAGGCCTGCTTCTGGTGGGCCCTTAAATTGCTATAATCGTAACCCCTAAATTCATTGATTTGGTTCCTATGTAAATGTGGCTCCCCTACACAGTTTACTTTGGCTG...
pathogenic
318,218
A mutation at chromosome position 34799295 on chromosome 21 in gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GCATGGTTTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACC...
GCATGGTTTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACC...
pathogenic
318,240
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 21, position 34799300, gene RUNX1 (RUNX family transcription factor 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
GTTTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGC...
GTTTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGC...
pathogenic
318,241
Is the genetic variant on chromosome 21, position 34799302, gene RUNX1 (RUNX family transcription factor 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCG...
TTTTATCTACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCG...
pathogenic
318,242
Chromosome 21, position 34799310, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
ACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAG...
ACTTCACACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAG...
pathogenic
318,245
Clinically, how would you classify the variant at chromosome 21, position 34799317, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
ACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTG...
ACTCCCATGCCATAAAATGTTCTCTCTTACTCCTTGGGTGATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTG...
benign
318,250
Clinical impact (benign or pathogenic) of the variant at chromosome 21, location 34799356, gene RUNX1 (RUNX family transcription factor 1): what disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGT...
GATTGAAGTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGT...
pathogenic
318,255
Variant chromosome 21, position 34799363, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease(s)?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAG...
GTCCAGGATATTCACAAATGTAACTGTGATATGGGACTTTGGAGTGCACATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAG...
pathogenic
318,256
Located at chromosome 21 position 34799411, the variant affecting gene RUNX1 (RUNX family transcription factor 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTG...
CATGTTACTCATTCCTTTTATTTAAAAAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTG...
pathogenic
318,264
Benign or pathogenic: chromosome 21, position 34799437, gene RUNX1 (RUNX family transcription factor 1) variant? Disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
AAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGA...
AAGTCACCCTACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGA...
pathogenic
318,272
Does the variant on chromosome 21 at location 34799447 affecting gene RUNX1 (RUNX family transcription factor 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
ACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATG...
ACCATCTGAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATG...
pathogenic
318,275
Clinical classification of chromosome 21, position 34799454, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
GAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATAT...
GAACACCAGTCAGCTGGAGGAGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATAT...
pathogenic
318,278
A genetic variant at chromosome 21, position 34799474, affecting gene RUNX1 (RUNX family transcription factor 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
benign
AGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATATTGGCATTAATGGCCAAAAGT...
AGTTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATATTGGCATTAATGGCCAAAAGT...
benign
318,286
Considering the genetic mutation at chromosome 21, position 34799476, impacting RUNX1 (RUNX family transcription factor 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
TTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATATTGGCATTAATGGCCAAAAGTAA...
TTGGCCCCTAGGGTTCTTGGACTATAAGGTGCTGATCTTGGGTGATGACCAAGTCAAAAGACTTATGTAATAAATTCCAAAGGATAGACCCATAGCAGGAACATTTGAAGGAGAACAGGCATTATTTCAGGTGAAGACCGTAGCCGGTGTGCAGAGGGGTGCCCTGAGAACAATCAGTAAAAGCTGACAAGTGCCTTTGTTCTTGAGGGATAAGCTTCTAGAAACCACAAGCTAAACAAGATGCCAAGATACCTGTGCTACTCTCAATGCCTTGGAGCAGAATGTACCATGAAAATATTGGCATTAATGGCCAAAAGTAA...
benign
318,288
Regarding the variant at chromosome 21 and position 34821685, affecting gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
benign
AGGGATGCCTTCATCTGGTCCCAGCTCTCTCCCTCTCATAGCCGTGTACTCTGTTGGGAGCAATTGGCATGAAGTTTGGCAGTGGCATCCTGAACCGGGATGACAGGACCATCAGTCAGCACCAGCCTCCCGCCCCTCCTGGCCTCGGCCTGCCAAAGCCTCGTATTCCCACAGCTGTGGCTCCAGCCTCTGCCCTGTCACACTCGCACACCTGTTTGCCATCCTGCTTCTGGCCCGCCAGCCCAAGCCACAGCCCCCAAGCAGGCTTAAAGGGCCGGGCTTGTGGGAGGAATCGGCACAGGATGGTATTTACTCAAAAT...
AGGGATGCCTTCATCTGGTCCCAGCTCTCTCCCTCTCATAGCCGTGTACTCTGTTGGGAGCAATTGGCATGAAGTTTGGCAGTGGCATCCTGAACCGGGATGACAGGACCATCAGTCAGCACCAGCCTCCCGCCCCTCCTGGCCTCGGCCTGCCAAAGCCTCGTATTCCCACAGCTGTGGCTCCAGCCTCTGCCCTGTCACACTCGCACACCTGTTTGCCATCCTGCTTCTGGCCCGCCAGCCCAAGCCACAGCCCCCAAGCAGGCTTAAAGGGCCGGGCTTGTGGGAGGAATCGGCACAGGATGGTATTTACTCAAAAT...
benign
318,293
Variant at chromosome 21, position 34834413, gene RUNX1 (RUNX family transcription factor 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
CCAAGAAACAGAGCAACTCAATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTG...
CCAAGAAACAGAGCAACTCAATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTG...
pathogenic
318,302
A genetic alteration at chromosome 21, position 34834414, in gene RUNX1 (RUNX family transcription factor 1)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CAAGAAACAGAGCAACTCAATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGC...
CAAGAAACAGAGCAACTCAATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGC...
pathogenic
318,303
Determine if the mutation at chromosome 21, position 34834432 in gene RUNX1 (RUNX family transcription factor 1) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
AATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTC...
AATGGTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTC...
pathogenic
318,307
Chromosome 21, position 34834436, gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Acute_myeloid_leukemia', 'Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
GTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTG...
GTGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTG...
pathogenic
318,308
A genetic variant at chromosome 21, position 34834437, affecting gene RUNX1 (RUNX family transcription factor 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
TGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGA...
TGACAATATCAATTTTCCCCCATGTGGCTGAATTTTCCATTGCCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGA...
pathogenic
318,309
Is the genetic mutation found on chromosome 21 at position 34834479, within the gene RUNX1 (RUNX family transcription factor 1), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTG...
CCTTTAAAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTG...
pathogenic
318,319
Does the variant on chromosome 21 at location 34834485 affecting gene RUNX1 (RUNX family transcription factor 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
AAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTT...
AAAATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTT...
pathogenic
318,320
A mutation at chromosome position 34834488 on chromosome 21 in gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
ATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAA...
ATGCTTAAGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAA...
pathogenic
318,322
Is chromosome 21, position 34834495, gene RUNX1 (RUNX family transcription factor 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
AGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATC...
AGACTTTTTGTTCCCATATCAGCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATC...
pathogenic
318,324
The genetic variant at chromosome 21, position 34834516, affecting gene RUNX1 (RUNX family transcription factor 1): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
GCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCAT...
GCAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCAT...
pathogenic
318,328
The mutation impacting RUNX1 (RUNX family transcription factor 1) on chromosome 21 at position 34834517: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
CAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATT...
CAGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATT...
pathogenic
318,330
Is the variant located on chromosome 21 at position 34834518, gene RUNX1 (RUNX family transcription factor 1), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
pathogenic
318,331
Assess the variant on chromosome 21, position 34834518, impacting RUNX1 (RUNX family transcription factor 1): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome']
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
pathogenic
318,332
Is the genetic variant on chromosome 21, position 34834518, gene RUNX1 (RUNX family transcription factor 1), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
AGAAAAAGGCAAATCCCTTAATCAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTA...
pathogenic
318,333
Variant on chromosome 21, at position 34834540, affecting RUNX1 (RUNX family transcription factor 1): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome', 'Hereditary_thrombocytopenia_and_hematological_cancer_predisposition_syndrome_associated_with_RUNX1']
CAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTATTAATGATTATTATGTAACAGG...
CAACCTAGTAGTATAAATGGCCAGTTAGGCAACGAGAGACTAAGAAAACAGTCTTCCTTTTGATTTTACACATGAATAGATGATGTGAATTAGTTTTCTGAAGATTATGTGAATTAGTTTAAATGACCTTAAAGGCAAGATGAAAGAATCTCCTTGAGAGTTGTATCCTCTTTGGAAGCAAAGTATTGTTTTGCCCCAAGCCCATCTCGCTCACTGAACATACCATTTGACTTAATTTACCATATACGCTTGTATTTTGGAATTTAAAAAAAATCAATGTACACATTTTAAATCATTATTAATGATTATTATGTAACAGG...
pathogenic
318,335