question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Mutation found at chromosome 21 position 45477930, gene COL18A1 (collagen type XVIII alpha 1 chain): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Knobloch_syndrome', 'Knobloch_syndrome_1']
TGTGAGCCTGACGACCAGGAGGAGAAGGCGGCGCAGGGAGCGCGCGGAAGGCTTTCCCCAGCTCGGGCCACCTGAGAAAACACAGGAGGGGCGGGGAGTGGGGAGGCCCCAGCCGCGGGACTGAGGCGCGGTGCTGTCCGTGAGAGACGGGTGCGGGAACGTGTTCCCTGCGGGGACCCTCTGCAGATTCACATCAGCTTCCCAGCATGGCCTGTCGGGCGCCGGGAGGCCTCTGTGGTGACGGCAGGCGCGGTCCTGGGTCCTGGGGAGCCGGGGAGCCCACAGGCGGCCACACCCCTGCGGCCCACGGAAGGAAGCCC...
TGTGAGCCTGACGACCAGGAGGAGAAGGCGGCGCAGGGAGCGCGCGGAAGGCTTTCCCCAGCTCGGGCCACCTGAGAAAACACAGGAGGGGCGGGGAGTGGGGAGGCCCCAGCCGCGGGACTGAGGCGCGGTGCTGTCCGTGAGAGACGGGTGCGGGAACGTGTTCCCTGCGGGGACCCTCTGCAGATTCACATCAGCTTCCCAGCATGGCCTGTCGGGCGCCGGGAGGCCTCTGTGGTGACGGCAGGCGCGGTCCTGGGTCCTGGGGAGCCGGGGAGCCCACAGGCGGCCACACCCCTGCGGCCCACGGAAGGAAGCCC...
pathogenic
320,331
Gene mutation in COL18A1 (collagen type XVIII alpha 1 chain) at chromosome 21, position 45477979—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
GGCTTTCCCCAGCTCGGGCCACCTGAGAAAACACAGGAGGGGCGGGGAGTGGGGAGGCCCCAGCCGCGGGACTGAGGCGCGGTGCTGTCCGTGAGAGACGGGTGCGGGAACGTGTTCCCTGCGGGGACCCTCTGCAGATTCACATCAGCTTCCCAGCATGGCCTGTCGGGCGCCGGGAGGCCTCTGTGGTGACGGCAGGCGCGGTCCTGGGTCCTGGGGAGCCGGGGAGCCCACAGGCGGCCACACCCCTGCGGCCCACGGAAGGAAGCCCCTCGCGCACGGCCCTGGAGCACCCTCCTGTTTCAGAGGATTTTTCTTTA...
GGCTTTCCCCAGCTCGGGCCACCTGAGAAAACACAGGAGGGGCGGGGAGTGGGGAGGCCCCAGCCGCGGGACTGAGGCGCGGTGCTGTCCGTGAGAGACGGGTGCGGGAACGTGTTCCCTGCGGGGACCCTCTGCAGATTCACATCAGCTTCCCAGCATGGCCTGTCGGGCGCCGGGAGGCCTCTGTGGTGACGGCAGGCGCGGTCCTGGGTCCTGGGGAGCCGGGGAGCCCACAGGCGGCCACACCCCTGCGGCCCACGGAAGGAAGCCCCTCGCGCACGGCCCTGGAGCACCCTCCTGTTTCAGAGGATTTTTCTTTA...
benign
320,333
Evaluate if the mutation on chromosome 21 at position 45479923 in COL18A1 (collagen type XVIII alpha 1 chain) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Knobloch_syndrome_1']
TGCAGGCCCAGCGTTGCAAACTGTCCCCGGACCACAAGGACCCCCAGGGCCTCCGGGGAGGGACGGCACCCCTGGAAGGGACGGCGAGCCGGTGAGTCCTCACGTCCCCCCGAGTCCGGCCCGGTCTGGAGGGTGGGGGCTTGGGTAGGAGGGGGAGAGGCTGCGGCCGACATGGGAGTGAGCTGAGCTGGGATCGGGGCAGGTCAGCAGCCTCCTTAGGCCCACCGTTGCTCGGGGTTGGTGCTGGAAGGTGGTCAGACGTGGGAGGCGGAGCTGCTCAGACACAGCCCTTGTGGGTGTGAGGAGGCTCCTGGCGCGGG...
TGCAGGCCCAGCGTTGCAAACTGTCCCCGGACCACAAGGACCCCCAGGGCCTCCGGGGAGGGACGGCACCCCTGGAAGGGACGGCGAGCCGGTGAGTCCTCACGTCCCCCCGAGTCCGGCCCGGTCTGGAGGGTGGGGGCTTGGGTAGGAGGGGGAGAGGCTGCGGCCGACATGGGAGTGAGCTGAGCTGGGATCGGGGCAGGTCAGCAGCCTCCTTAGGCCCACCGTTGCTCGGGGTTGGTGCTGGAAGGTGGTCAGACGTGGGAGGCGGAGCTGCTCAGACACAGCCCTTGTGGGTGTGAGGAGGCTCCTGGCGCGGG...
pathogenic
320,339
Clinical significance of chromosome 21, position 45480834, gene COL18A1 (collagen type XVIII alpha 1 chain): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic
AGTAATGACGTGATCGACTGCGAATAAAGACCTGGGAACAGCCTGCCCAGCAAATGGTAACACTCGGCAGAAAGTGGGGCCGTCACGAACGCTGGACAGGAGGGTTCAAGTTAAAAACAGTCTAGAAGGTCTGAAAGGACAGGGAGGGCATCTCATGGTGCCCACCGAACGGTCATTACCGACCGCCTGGCACCCCACAGCCAAGCTGCCTGCGATGAGGACCACGGCAGACAAAGGACAGTCGGCTGGGGGGCGGCACGGGGCCCACCCACTGCAACAGGGTACACGCACGCGTGTGAGTGTGGGGTGATGATCCACGG...
AGTAATGACGTGATCGACTGCGAATAAAGACCTGGGAACAGCCTGCCCAGCAAATGGTAACACTCGGCAGAAAGTGGGGCCGTCACGAACGCTGGACAGGAGGGTTCAAGTTAAAAACAGTCTAGAAGGTCTGAAAGGACAGGGAGGGCATCTCATGGTGCCCACCGAACGGTCATTACCGACCGCCTGGCACCCCACAGCCAAGCTGCCTGCGATGAGGACCACGGCAGACAAAGGACAGTCGGCTGGGGGGCGGCACGGGGCCCACCCACTGCAACAGGGTACACGCACGCGTGTGAGTGTGGGGTGATGATCCACGG...
pathogenic
320,357
Assess the variant on chromosome 21, position 45488455, impacting COL18A1 (collagen type XVIII alpha 1 chain): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
benign
GAGCCAGGGCTGGTCCCAGGGTCCTGAGCCTCCTCTCCTCTCTCCTCTCTTTTCCCCTCGCCTGCCCGGGAGCCAGGGCTGGTCCCAGGGTCCTGAGCCTCCTCTCCTCTCTCCTCTCTTCTCCCCTTGCCTGCCCGGGAGCCAGGGCTGGAGGTAACGAGGGTGCCCTGTGCACCTCCCGCTGTGCATGTGGGCCTCCCCCTGTGCATGTGGGCCCAACCCCGACCAAGTTCGGGCTCCGTGGCTCTCTCCTCAGTTGTGTTTCTGTGTGGCTGAAATCGTGTCGTAAAGTTAGAAGAAAGGCTGCTGTGGGGCCTGCG...
GAGCCAGGGCTGGTCCCAGGGTCCTGAGCCTCCTCTCCTCTCTCCTCTCTTTTCCCCTCGCCTGCCCGGGAGCCAGGGCTGGTCCCAGGGTCCTGAGCCTCCTCTCCTCTCTCCTCTCTTCTCCCCTTGCCTGCCCGGGAGCCAGGGCTGGAGGTAACGAGGGTGCCCTGTGCACCTCCCGCTGTGCATGTGGGCCTCCCCCTGTGCATGTGGGCCCAACCCCGACCAAGTTCGGGCTCCGTGGCTCTCTCCTCAGTTGTGTTTCTGTGTGGCTGAAATCGTGTCGTAAAGTTAGAAGAAAGGCTGCTGTGGGGCCTGCG...
benign
320,379
A genetic variant on chromosome 21, position 45491268, affects the gene COL18A1 (collagen type XVIII alpha 1 chain). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['COL18A1-related_disorder', 'Knobloch_syndrome']
CGGGGTTCCTCTTGCAGTCTGCAGTCCTAGTGATGGAATATGTCCCCAGGTTCCGCAGCCGTCCCGGCCGGGTGCCTTCAGCCAGCCTGGGCCCACGGGGTCCCTGCACAAGTTGCTCAGTGTCCCTGGGACCCCTCGGCTCTGGGCTGGGGGAGGGCGGTGAGATGCATCCTGGGTAACTCACCCTTCCCTTCACCCGGGGTGGACGCTGCCTGAGGACTGGGCTGGCCCCAGCAGGTGCTCACGGAGCCCCTTTTTTCACTTAGGGGGATCCTGGCGTGCCTGGGCTGCCGGGGGCGAAGGTAAGCGCTGTGCCCGGG...
CGGGGTTCCTCTTGCAGTCTGCAGTCCTAGTGATGGAATATGTCCCCAGGTTCCGCAGCCGTCCCGGCCGGGTGCCTTCAGCCAGCCTGGGCCCACGGGGTCCCTGCACAAGTTGCTCAGTGTCCCTGGGACCCCTCGGCTCTGGGCTGGGGGAGGGCGGTGAGATGCATCCTGGGTAACTCACCCTTCCCTTCACCCGGGGTGGACGCTGCCTGAGGACTGGGCTGGCCCCAGCAGGTGCTCACGGAGCCCCTTTTTTCACTTAGGGGGATCCTGGCGTGCCTGGGCTGCCGGGGGCGAAGGTAAGCGCTGTGCCCGGG...
pathogenic
320,403
Is the genetic mutation found on chromosome 21 at position 45491385, within the gene COL18A1 (collagen type XVIII alpha 1 chain), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
CAGTGTCCCTGGGACCCCTCGGCTCTGGGCTGGGGGAGGGCGGTGAGATGCATCCTGGGTAACTCACCCTTCCCTTCACCCGGGGTGGACGCTGCCTGAGGACTGGGCTGGCCCCAGCAGGTGCTCACGGAGCCCCTTTTTTCACTTAGGGGGATCCTGGCGTGCCTGGGCTGCCGGGGGCGAAGGTAAGCGCTGTGCCCGGGTTCAGGGACGTGGCCAGGCAGAGGCAGGGAGGGCCCAGCCGGACACCTGCGGAGATCAGCTCGGGGCGGCCTTCCCCGCTCTTCCTGCCACTGCTTTGTTTCTTTATAATTGAAGAC...
CAGTGTCCCTGGGACCCCTCGGCTCTGGGCTGGGGGAGGGCGGTGAGATGCATCCTGGGTAACTCACCCTTCCCTTCACCCGGGGTGGACGCTGCCTGAGGACTGGGCTGGCCCCAGCAGGTGCTCACGGAGCCCCTTTTTTCACTTAGGGGGATCCTGGCGTGCCTGGGCTGCCGGGGGCGAAGGTAAGCGCTGTGCCCGGGTTCAGGGACGTGGCCAGGCAGAGGCAGGGAGGGCCCAGCCGGACACCTGCGGAGATCAGCTCGGGGCGGCCTTCCCCGCTCTTCCTGCCACTGCTTTGTTTCTTTATAATTGAAGAC...
benign
320,409
Does the variant on chromosome 21 at location 45492744 affecting gene COL18A1 (collagen type XVIII alpha 1 chain) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
CTCTTGGTGGCTGCCTCCCTCCCAGGCCCCAGCCGGTCGGGAAATAAAGAACCCCACATCTTCATCAGAGCCATCCCTCACGGGGGGCCAGGGGCTCCTGTTTCTGTTGGTGATGAACCATTTCCTTCCTGTCTCTCCAGGGGCCAAAGGGAGACAGAGGCAGCCGGGGAGAAAAGGTGAGTGTCCCTGGGGCGGGTGGATGGGGATGGGGGGCGCTGGGACATCCCAGAAGGTTTGGCCTCAGCTGCCCCAGGTCCGTGCCCCTGCTGCCCATGTGACCTCAGAGACTCAGGGCAAAGACCCTCAAGTTGACAGGGGTG...
CTCTTGGTGGCTGCCTCCCTCCCAGGCCCCAGCCGGTCGGGAAATAAAGAACCCCACATCTTCATCAGAGCCATCCCTCACGGGGGGCCAGGGGCTCCTGTTTCTGTTGGTGATGAACCATTTCCTTCCTGTCTCTCCAGGGGCCAAAGGGAGACAGAGGCAGCCGGGGAGAAAAGGTGAGTGTCCCTGGGGCGGGTGGATGGGGATGGGGGGCGCTGGGACATCCCAGAAGGTTTGGCCTCAGCTGCCCCAGGTCCGTGCCCCTGCTGCCCATGTGACCTCAGAGACTCAGGGCAAAGACCCTCAAGTTGACAGGGGTG...
benign
320,414
Is the variant located on chromosome 21 at position 45496602, gene COL18A1 (collagen type XVIII alpha 1 chain), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
GGCTTCCGAGGACCCCCGGTAAGTCGGTCCCTGGCTTTCTCTGCACTGAGCTCGGGCATGACGGCCCCCAAGGACACGGTCGCCCGCGGCTGCTGAGCTTGTGCTGTGCGGCCCAGGGCTCATCTCCCTAGTGCAGTTTTAAAGCGTGTGGGGCAGGTGTCGGCGTGAGGCTGCAGTGGGCTCCTCCGAGCTGATGGGTGGCCCAGGGTGCTGTGCTCTGCATGGCCCCTCCCCTTCCCCAGGACCCCCCAACTCGTGGTCAAGGGCCAGGGTCTGCCCCACTAAGCCTGGCCCCCTTCCTCTTGCAGGGTCCATACGGA...
GGCTTCCGAGGACCCCCGGTAAGTCGGTCCCTGGCTTTCTCTGCACTGAGCTCGGGCATGACGGCCCCCAAGGACACGGTCGCCCGCGGCTGCTGAGCTTGTGCTGTGCGGCCCAGGGCTCATCTCCCTAGTGCAGTTTTAAAGCGTGTGGGGCAGGTGTCGGCGTGAGGCTGCAGTGGGCTCCTCCGAGCTGATGGGTGGCCCAGGGTGCTGTGCTCTGCATGGCCCCTCCCCTTCCCCAGGACCCCCCAACTCGTGGTCAAGGGCCAGGGTCTGCCCCACTAAGCCTGGCCCCCTTCCTCTTGCAGGGTCCATACGGA...
benign
320,438
Chromosome 21, position 45497644, gene COL18A1 (collagen type XVIII alpha 1 chain): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Knobloch_syndrome', 'Knobloch_syndrome_1']
ATGTCCACACACGCACACGTGTGCCCAAACATGCATGCACATATATGGCCGTACTCATACATGTGTGCACATATACACATGCATCTATGCACATACATGCCCATACACACGCGCACACATACACGCACACACACATCCACACGTGCTCATGTGTGTACACATGCCCATACACTCCACATAGGTGCACATATACACATGTATTCATGCATATACGAGCCTGTCCACGTGCACACCCATACAGGTATATACATACACTCATACATGTGCACGTATCCACATGTGTATCCACATACATGACTATGAGCCCTCCCTGGCCCATT...
ATGTCCACACACGCACACGTGTGCCCAAACATGCATGCACATATATGGCCGTACTCATACATGTGTGCACATATACACATGCATCTATGCACATACATGCCCATACACACGCGCACACATACACGCACACACACATCCACACGTGCTCATGTGTGTACACATGCCCATACACTCCACATAGGTGCACATATACACATGTATTCATGCATATACGAGCCTGTCCACGTGCACACCCATACAGGTATATACATACACTCATACATGTGCACGTATCCACATGTGTATCCACATACATGACTATGAGCCCTCCCTGGCCCATT...
pathogenic
320,440
Variant in COL18A1 (collagen type XVIII alpha 1 chain), chromosome 21, position 45497644—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Knobloch_syndrome']
ATGTCCACACACGCACACGTGTGCCCAAACATGCATGCACATATATGGCCGTACTCATACATGTGTGCACATATACACATGCATCTATGCACATACATGCCCATACACACGCGCACACATACACGCACACACACATCCACACGTGCTCATGTGTGTACACATGCCCATACACTCCACATAGGTGCACATATACACATGTATTCATGCATATACGAGCCTGTCCACGTGCACACCCATACAGGTATATACATACACTCATACATGTGCACGTATCCACATGTGTATCCACATACATGACTATGAGCCCTCCCTGGCCCATT...
ATGTCCACACACGCACACGTGTGCCCAAACATGCATGCACATATATGGCCGTACTCATACATGTGTGCACATATACACATGCATCTATGCACATACATGCCCATACACACGCGCACACATACACGCACACACACATCCACACGTGCTCATGTGTGTACACATGCCCATACACTCCACATAGGTGCACATATACACATGTATTCATGCATATACGAGCCTGTCCACGTGCACACCCATACAGGTATATACATACACTCATACATGTGCACGTATCCACATGTGTATCCACATACATGACTATGAGCCCTCCCTGGCCCATT...
pathogenic
320,441
Is the genetic variant on chromosome 21, position 45503996, gene SLC19A1, benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
CAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCCGAAGGACCCCCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCGGAGCAGGGCCCAGCCCGAGAGGGAGCACGGGTCCTGACAGCAGCAGTGACCTCCAACCCCAGGGACGGCTCCTGTGGGATGGGGGGCCCTGGGGGTGTGGAGCCACGTGCTCCAAAGCTTCTGGGTTACAGGGCATGCCTCCAGGG...
CAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCCGAAGGACCCCCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCGGAGCAGGGCCCAGCCCGAGAGGGAGCACGGGTCCTGACAGCAGCAGTGACCTCCAACCCCAGGGACGGCTCCTGTGGGATGGGGGGCCCTGGGGGTGTGGAGCCACGTGCTCCAAAGCTTCTGGGTTACAGGGCATGCCTCCAGGG...
benign
320,445
Regarding the variant at chromosome 21 and position 45504028, affecting gene SLC19A1: benign or pathogenic? If pathogenic, what are the associated illness(es)?
benign
CAGAAGGACCCTCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCCGAAGGACCCCCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCGGAGCAGGGCCCAGCCCGAGAGGGAGCACGGGTCCTGACAGCAGCAGTGACCTCCAACCCCAGGGACGGCTCCTGTGGGATGGGGGGCCCTGGGGGTGTGGAGCCACGTGCTCCAAAGCTTCTGGGTTACAGGGCATGCCTCCAGGGGTGAGGTGGTCCCCACCCCGGTCACGGTTTCA...
CAGAAGGACCCTCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCTCAGGGGCCTCCGCAGCCGGTCACCTCCCTCTGCCGAAGGACCCCCAGGGGCTCCACAGCCGGTCACCTCCCTCTGCAGAAGGACCCGGAGCAGGGCCCAGCCCGAGAGGGAGCACGGGTCCTGACAGCAGCAGTGACCTCCAACCCCAGGGACGGCTCCTGTGGGATGGGGGGCCCTGGGGGTGTGGAGCCACGTGCTCCAAAGCTTCTGGGTTACAGGGCATGCCTCCAGGGGTGAGGTGGTCCCCACCCCGGTCACGGTTTCA...
benign
320,448
Gene SLC19A1 variant at chromosome 21, position 45504511—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
benign
AAACAGTTATTTGATGAAAATAGATGGGAAGAAGTATTAAACATCAAAAATGAGTGAAGAGAAATTGCGTATGTTTTATATATAAAAATAGCAAGGATCAAGAAAGTCCAAAAATCCAAAGTTAATTCTTTGCAAAGGCGAACAACATTCCTGCACCTCTGCCGGGACTGAGGAAAAGGAGAGAAGCAGCAACAAGCAGGGATTTCAGCAAAGGGCTCCTCCGTGGTCTGGAAGGAGCCACCTGGAACTGCCACAGCTTCACCCTTGGAGAGGGTGGAGGGACCCTCAAGTCAGGGCCAAGACACAGCTGCCTGCCCACC...
AAACAGTTATTTGATGAAAATAGATGGGAAGAAGTATTAAACATCAAAAATGAGTGAAGAGAAATTGCGTATGTTTTATATATAAAAATAGCAAGGATCAAGAAAGTCCAAAAATCCAAAGTTAATTCTTTGCAAAGGCGAACAACATTCCTGCACCTCTGCCGGGACTGAGGAAAAGGAGAGAAGCAGCAACAAGCAGGGATTTCAGCAAAGGGCTCCTCCGTGGTCTGGAAGGAGCCACCTGGAACTGCCACAGCTTCACCCTTGGAGAGGGTGGAGGGACCCTCAAGTCAGGGCCAAGACACAGCTGCCTGCCCACC...
benign
320,460
Regarding the variant at chromosome 21 and position 45504511, affecting gene SLC19A1: benign or pathogenic? If pathogenic, what are the associated illness(es)?
benign
AAACAGTTATTTGATGAAAATAGATGGGAAGAAGTATTAAACATCAAAAATGAGTGAAGAGAAATTGCGTATGTTTTATATATAAAAATAGCAAGGATCAAGAAAGTCCAAAAATCCAAAGTTAATTCTTTGCAAAGGCGAACAACATTCCTGCACCTCTGCCGGGACTGAGGAAAAGGAGAGAAGCAGCAACAAGCAGGGATTTCAGCAAAGGGCTCCTCCGTGGTCTGGAAGGAGCCACCTGGAACTGCCACAGCTTCACCCTTGGAGAGGGTGGAGGGACCCTCAAGTCAGGGCCAAGACACAGCTGCCTGCCCACC...
AAACAGTTATTTGATGAAAATAGATGGGAAGAAGTATTAAACATCAAAAATGAGTGAAGAGAAATTGCGTATGTTTTATATATAAAAATAGCAAGGATCAAGAAAGTCCAAAAATCCAAAGTTAATTCTTTGCAAAGGCGAACAACATTCCTGCACCTCTGCCGGGACTGAGGAAAAGGAGAGAAGCAGCAACAAGCAGGGATTTCAGCAAAGGGCTCCTCCGTGGTCTGGAAGGAGCCACCTGGAACTGCCACAGCTTCACCCTTGGAGAGGGTGGAGGGACCCTCAAGTCAGGGCCAAGACACAGCTGCCTGCCCACC...
benign
320,461
Evaluate this variant at chromosome 21, position 45505235, gene SLC19A1: benign or pathogenic? If pathogenic, what are the disease connection(s)?
benign
ACAGTGTAAAAGTGTTCCTATTTCTCTACATCCTCTCCGGCACCTGTTGTTTCCTTACTTTTTAACGATCGCCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAA...
ACAGTGTAAAAGTGTTCCTATTTCTCTACATCCTCTCCGGCACCTGTTGTTTCCTTACTTTTTAACGATCGCCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAA...
benign
320,470
Clinical classification of chromosome 21, position 45505235, gene SLC19A1: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Knobloch_syndrome']
ACAGTGTAAAAGTGTTCCTATTTCTCTACATCCTCTCCGGCACCTGTTGTTTCCTTACTTTTTAACGATCGCCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAA...
ACAGTGTAAAAGTGTTCCTATTTCTCTACATCCTCTCCGGCACCTGTTGTTTCCTTACTTTTTAACGATCGCCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAA...
pathogenic
320,472
Does the variant impacting SLC19A1 on chromosome 21, position 45505371, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic
GATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAAATCATCATTCTCAGTAAACTATTGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAACTGAACAATGAGATCACATGGACACAGGAAGGGGAACATCACACTCTGGGGACTGTTGTGGGGTG...
GATGATGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAAATCATCATTCTCAGTAAACTATTGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAACTGAACAATGAGATCACATGGACACAGGAAGGGGAACATCACACTCTGGGGACTGTTGTGGGGTG...
pathogenic
320,479
Located at chromosome 21 position 45505379, the variant affecting gene SLC19A1—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Knobloch_syndrome_1']
GCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAAATCATCATTCTCAGTAAACTATTGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAACTGAACAATGAGATCACATGGACACAGGAAGGGGAACATCACACTCTGGGGACTGTTGTGGGGTGGGGGGAGG...
GCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTGGCACATATACACCATGGAATACTACGCAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAATTGGAAATCATCATTCTCAGTAAACTATTGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAACTGAACAATGAGATCACATGGACACAGGAAGGGGAACATCACACTCTGGGGACTGTTGTGGGGTGGGGGGAGG...
pathogenic
320,480
Variant chromosome 21, position 45509608, gene SLC19A1: benign or pathogenic? Disease(s)?
benign
GCTGGAGGCCCGGACACCACTCCCACGAGGGACGGTAAGGAGCCTTTTTTCTGTTGAGACTGGTGGGTGGTCAGGACATGAGGGGGTATGTGCTGTCCCCTGTTTGAGGAACAACACGTGGTCCTTTGGAGTCCTGGAGCTGAACATGTGGCTCACCATCAGCCCCTGCTGCAGAAACTGGTGCAGGACACCCCACTACCTCTGTCTCAGCGCTGGCCCCCCAGTACCTCCGTCTCAGCTGCTGGCCTCACGAGGGAGCCCCTCTCATCCCTCAACTTTCCCAGTTGTGTCTGCCGCTCATTGCCCTCCTCAAGGTCAAA...
GCTGGAGGCCCGGACACCACTCCCACGAGGGACGGTAAGGAGCCTTTTTTCTGTTGAGACTGGTGGGTGGTCAGGACATGAGGGGGTATGTGCTGTCCCCTGTTTGAGGAACAACACGTGGTCCTTTGGAGTCCTGGAGCTGAACATGTGGCTCACCATCAGCCCCTGCTGCAGAAACTGGTGCAGGACACCCCACTACCTCTGTCTCAGCGCTGGCCCCCCAGTACCTCCGTCTCAGCTGCTGGCCTCACGAGGGAGCCCCTCTCATCCCTCAACTTTCCCAGTTGTGTCTGCCGCTCATTGCCCTCCTCAAGGTCAAA...
benign
320,506
Clinical impact (benign or pathogenic) of the variant at chromosome 21, location 45510090, gene SLC19A1: what disease(s) if pathogenic?
pathogenic; ['Hereditary_glaucoma,_primary_closed-angle', 'Knobloch_syndrome', 'Knobloch_syndrome_1', 'Macular_dystrophy', 'Retinal_dystrophy', 'Retinitis_pigmentosa']
TAGGTAGATGGGGAGGTGGATGGATGAGTAGATGGTGGACAGGTGGGTGAGTGGATGGATGGTGGTCAGGCGGGTGAGTGGACGGGTGGGTGGGTGGATGGAAAGGTGGGTGAGTGGATAGGTAGGTAGCTGGGGAGATGGATGGATGGTGGACAGGTGGGTGAGTGTATGAATGGGTGGGTGGATAGTGGGTAAGTGGGTGAGTGGATGGTGGACAGGTGGGTGAGTGGATGGGTAGGTAGATGGGGAGGTGGATGGGTGGTTGCTGGACAGGTGGGTGAGTGGATAGATGGGCAGATGGATGGTGGACAAGTGGGTGA...
TAGGTAGATGGGGAGGTGGATGGATGAGTAGATGGTGGACAGGTGGGTGAGTGGATGGATGGTGGTCAGGCGGGTGAGTGGACGGGTGGGTGGGTGGATGGAAAGGTGGGTGAGTGGATAGGTAGGTAGCTGGGGAGATGGATGGATGGTGGACAGGTGGGTGAGTGTATGAATGGGTGGGTGGATAGTGGGTAAGTGGGTGAGTGGATGGTGGACAGGTGGGTGAGTGGATGGGTAGGTAGATGGGGAGGTGGATGGGTGGTTGCTGGACAGGTGGGTGAGTGGATAGATGGGCAGATGGATGGTGGACAAGTGGGTGA...
pathogenic
320,513
Located at chromosome 21 position 45511090, the variant affecting gene SLC19A1—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
GGGGCCCTGAATTGGAGCCGCGGCAAAGGAGAGGGCAGGTCAGGGCACGTGGTGAGTGATTGCTGCGGCTTCTGAGCACGGCTGGGTCTGTGGGGCCTGAGCAGAGGTGACCCGCGATCCGGCGCCACGGCAGGCAGGACTCCCCACCCTTGCTGCTGCCTACACCCCCAGGGCAGCCCCAGAGTCGGGGGCGCAGCTCCCTGCTTGCCAGTTCAGAGCCCAGCCCCTCTCACCCAGCCCAGAGGAGGACACAGATGGAGGAGGGGCACCCGGAGGGTCCCCCCGCCGACAGGCCCCACGTCTCCCACCTGCAGGACAAT...
GGGGCCCTGAATTGGAGCCGCGGCAAAGGAGAGGGCAGGTCAGGGCACGTGGTGAGTGATTGCTGCGGCTTCTGAGCACGGCTGGGTCTGTGGGGCCTGAGCAGAGGTGACCCGCGATCCGGCGCCACGGCAGGCAGGACTCCCCACCCTTGCTGCTGCCTACACCCCCAGGGCAGCCCCAGAGTCGGGGGCGCAGCTCCCTGCTTGCCAGTTCAGAGCCCAGCCCCTCTCACCCAGCCCAGAGGAGGACACAGATGGAGGAGGGGCACCCGGAGGGTCCCCCCGCCGACAGGCCCCACGTCTCCCACCTGCAGGACAAT...
benign
320,527
Clinical significance of chromosome 21, position 45981900, gene COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Bethlem_myopathy_1A']
GGTAAATTGACTGTACAGTAAGTGTACAAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGGCAGGAGGACCACTTGAGTCCAGGAGTTCGAGACCAGCCTGGGCAACATCGTGAGACCCCCATCTCTACAAAACATACAAAATTAGCTGGGTATGGTGGCACATGCCTGTGATCCCAGCTACTCGGGAGGCTGAGGTGGAGGGATCACCTGAACCCAGGAGACTGAGGCTGCAGTGAGCTGTGATGAGGCCACTACGTTCCAGCCTGGATGACAGAGTGAGCCCCTTAGATAATAATAAT...
GGTAAATTGACTGTACAGTAAGTGTACAAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGGCAGGAGGACCACTTGAGTCCAGGAGTTCGAGACCAGCCTGGGCAACATCGTGAGACCCCCATCTCTACAAAACATACAAAATTAGCTGGGTATGGTGGCACATGCCTGTGATCCCAGCTACTCGGGAGGCTGAGGTGGAGGGATCACCTGAACCCAGGAGACTGAGGCTGCAGTGAGCTGTGATGAGGCCACTACGTTCCAGCCTGGATGACAGAGTGAGCCCCTTAGATAATAATAAT...
pathogenic
320,563
Gene mutation in COL6A1 (collagen type VI alpha 1 chain) at chromosome 21, position 45982628—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Bethlem_myopathy_1A']
CTCTGTCTGTCTCTCCTCTCTGTCTCTCTCTGTCTCTGTCTCTCTGTCTCTGTCTTTGTCTCTCTCTGTCTCTCCTCTCTCTGTGTCTCTGTCTCTGTCTCTCTCTCTGTCTCTCTCTGTCTGTCTCTCTGTCTCTCTCTGTCTCTGTCTCTCTCTGTCTGTCTCTGTCTCTCCTCTGTCTCTCTGTGTCTGTCTCTCTGTCTCTGTCTTTCTGTCTCTCTCTCACTGTCTCTGTCTCTCTCTGTCTCTCTGTCTCTGTGTCTCTCTGTCTCTGTCTCTCACTGTCTCTCTCTCTGTCTCTGTCTCTCTGTCTCTCTGTC...
CTCTGTCTGTCTCTCCTCTCTGTCTCTCTCTGTCTCTGTCTCTCTGTCTCTGTCTTTGTCTCTCTCTGTCTCTCCTCTCTCTGTGTCTCTGTCTCTGTCTCTCTCTCTGTCTCTCTCTGTCTGTCTCTCTGTCTCTCTCTGTCTCTGTCTCTCTCTGTCTGTCTCTGTCTCTCCTCTGTCTCTCTGTGTCTGTCTCTCTGTCTCTGTCTTTCTGTCTCTCTCTCACTGTCTCTGTCTCTCTCTGTCTCTCTGTCTCTGTGTCTCTCTGTCTCTGTCTCTCACTGTCTCTCTCTCTGTCTCTGTCTCTCTGTCTCTCTGTC...
pathogenic
320,565
Clinically, how would you classify the variant at chromosome 21, position 45986696, gene COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
AGAGAAACAGAAACAGGGAGAAACAGACACAGAGAGAGACAGAGACAGAGAGAGATAGAGACAGAGACAGAGAGAGACAGAGACAAAGAGTGACAGAGGGACCAAGACAGGCAGACAGAGACAAACAGAGACAGAGACAGAGACACAGAGAGAGACACAGAGAGACAGAGACGGGAACAGAGACAGGCAGACAGAGACAGAGAGAGACAGAGACAGAAACAGAGACAGAGGGACAGAGACAGGCAGAGAGAGACAGAGAGACAGAGACAGAGACAGACAAACAGAGACAGAGAGACAGAAACAGGGACAGAGACAGAAAG...
AGAGAAACAGAAACAGGGAGAAACAGACACAGAGAGAGACAGAGACAGAGAGAGATAGAGACAGAGACAGAGAGAGACAGAGACAAAGAGTGACAGAGGGACCAAGACAGGCAGACAGAGACAAACAGAGACAGAGACAGAGACACAGAGAGAGACACAGAGAGACAGAGACGGGAACAGAGACAGGCAGACAGAGACAGAGAGAGACAGAGACAGAAACAGAGACAGAGGGACAGAGACAGGCAGAGAGAGACAGAGAGACAGAGACAGAGACAGACAAACAGAGACAGAGAGACAGAAACAGGGACAGAGACAGAAAG...
benign
320,584
Is the variant located on chromosome 21 at position 45987485, gene COL6A1 (collagen type VI alpha 1 chain), benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
AGAGACTGAGAGACTGAGAGAGACGGGGTGGTTTTCCCCACAGCATCAACACCAAGCAGGGCTAGGATCACTGAAACAGACTCATCAGACCCGAAGCATGCGCTTTCTCGGGGTTTTTCTGGACTGAGGGGTTTCCTCTCATCCCAGTGTCCAGCTGTGGGGACGCAGGGGCCGCAAGCCCCGGAGTGTCCAGAGGGGAACGTGGCCTCCCCACACCCAGCCCTTCACGAGGCCTCAGGATCCCAGTGGGGGTACCCGAGGCTGCCCTGTCCAGCCAGGCGGTGCGGGGGGTTTGGGGAGAGCCTCTCCCCGAGGTCGGT...
AGAGACTGAGAGACTGAGAGAGACGGGGTGGTTTTCCCCACAGCATCAACACCAAGCAGGGCTAGGATCACTGAAACAGACTCATCAGACCCGAAGCATGCGCTTTCTCGGGGTTTTTCTGGACTGAGGGGTTTCCTCTCATCCCAGTGTCCAGCTGTGGGGACGCAGGGGCCGCAAGCCCCGGAGTGTCCAGAGGGGAACGTGGCCTCCCCACACCCAGCCCTTCACGAGGCCTCAGGATCCCAGTGGGGGTACCCGAGGCTGCCCTGTCCAGCCAGGCGGTGCGGGGGGTTTGGGGAGAGCCTCTCCCCGAGGTCGGT...
benign
320,593
Determine if the mutation at chromosome 21, position 45987622 in gene COL6A1 (collagen type VI alpha 1 chain) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Bethlem_myopathy_1A']
CTCATCCCAGTGTCCAGCTGTGGGGACGCAGGGGCCGCAAGCCCCGGAGTGTCCAGAGGGGAACGTGGCCTCCCCACACCCAGCCCTTCACGAGGCCTCAGGATCCCAGTGGGGGTACCCGAGGCTGCCCTGTCCAGCCAGGCGGTGCGGGGGGTTTGGGGAGAGCCTCTCCCCGAGGTCGGTCTCAGAGGGCCACATGGCCGGTGTGGGCCGGACATTCCCTTTCCAATGGTTGTGCCCACTTCCCTCCAGAGTTGGTGCCAAGCTGGGACCTGGGGGACTTGGAGTCTCAGGAAGTCGTCCGCTGTCTGCAGGGGGTG...
CTCATCCCAGTGTCCAGCTGTGGGGACGCAGGGGCCGCAAGCCCCGGAGTGTCCAGAGGGGAACGTGGCCTCCCCACACCCAGCCCTTCACGAGGCCTCAGGATCCCAGTGGGGGTACCCGAGGCTGCCCTGTCCAGCCAGGCGGTGCGGGGGGTTTGGGGAGAGCCTCTCCCCGAGGTCGGTCTCAGAGGGCCACATGGCCGGTGTGGGCCGGACATTCCCTTTCCAATGGTTGTGCCCACTTCCCTCCAGAGTTGGTGCCAAGCTGGGACCTGGGGGACTTGGAGTCTCAGGAAGTCGTCCGCTGTCTGCAGGGGGTG...
pathogenic
320,596
Chromosome 21, position 45989773, gene COL6A1 (collagen type VI alpha 1 chain): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Bethlem_myopathy_1A', 'Ullrich_congenital_muscular_dystrophy_1A']
CTGGGCACCCAAGTCCACCATGAGGATCCAGAGGGGACGGCGGGGGTCCAGATGGAGGGGACGGCGGGGGTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGATGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGATGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGTCGGGGCTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACG...
CTGGGCACCCAAGTCCACCATGAGGATCCAGAGGGGACGGCGGGGGTCCAGATGGAGGGGACGGCGGGGGTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGATGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGATGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGTCGGGGCTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACG...
pathogenic
320,632
Variant in COL6A1 (collagen type VI alpha 1 chain), chromosome 21, position 45990283—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Bethlem_myopathy_1A']
GGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGACGGCGTGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGTCGGGGCTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGATGTCGGGGTCCAGATGGAAGGGACGGCGGGGTCCAGCAGGCAGGCTCCGGCCGTGCAGGGTGTGGACTGTCCCGGGGGCGCTGGGGGCTTCT...
GGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGGCGGGAGTCCAGATGGAGGGGACGGCGTGGTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGACGTCGGGGCTCCAGATGGAGGGGACGGCGGGGTCCAGATGGAGGGGATGTCGGGGTCCAGATGGAAGGGACGGCGGGGTCCAGCAGGCAGGCTCCGGCCGTGCAGGGTGTGGACTGTCCCGGGGGCGCTGGGGGCTTCT...
pathogenic
320,644
Evaluate the clinical significance of the mutation at chromosome 21, position 45990754 in gene COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
GCCATGAGGCTGCTCATGGACCTCAGATTTCTGGCTTCTCCTAAAAACCATCAAACCCAGCAGCTGTGGGCCCGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTG...
GCCATGAGGCTGCTCATGGACCTCAGATTTCTGGCTTCTCCTAAAAACCATCAAACCCAGCAGCTGTGGGCCCGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTG...
benign
320,662
Gene COL6A1 (collagen type VI alpha 1 chain) variant at chromosome position 45990770 on chromosome 21: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Bethlem_myopathy_1A']
TGGACCTCAGATTTCTGGCTTCTCCTAAAAACCATCAAACCCAGCAGCTGTGGGCCCGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAA...
TGGACCTCAGATTTCTGGCTTCTCCTAAAAACCATCAAACCCAGCAGCTGTGGGCCCGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAA...
pathogenic
320,663
A genetic variant at chromosome 21, position 45990826, affecting gene COL6A1 (collagen type VI alpha 1 chain)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Bethlem_myopathy_1A']
CGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAAAGAAACGGGGCTGCCCCAACCTTGACCTGTTTTGTGTTCCAGGGAGAACGAGGCAA...
CGAGTCCCATGGCCATTTCCTGGGGGTCGAGCTGTGACCCTGGGGGGCTTCTGTGCTGCACGTCCCTCCCACCTGTGCCTGGGGGTCAGCAAAGCCGAGCAGACAGGAACGAAGGCAGGGAGTGGGGGGAGCTGGCGTGCGGGTTGGAGCTCCCAGACCCAGGCTGACCAGATGTGATGGGGAAGGTGCTTTAAAGCCCTTGATCCCTGAAGGCTGGATGAAGCGTCTTTTTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAAAGAAACGGGGCTGCCCCAACCTTGACCTGTTTTGTGTTCCAGGGAGAACGAGGCAA...
pathogenic
320,670
Gene mutation in COL6A1 (collagen type VI alpha 1 chain) at chromosome 21, position 45991056—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
TTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAAAGAAACGGGGCTGCCCCAACCTTGACCTGTTTTGTGTTCCAGGGAGAACGAGGCAAGCCGGGGCTCCCAGGAGAGAAGGGAGAAGCCGGAGATCCTGTGAGTGCCTGACTGTGGGGTGGGGGCCCTAAGAAGCTGGAGGCGGGGAACGACTAGGCCTCGGAAACTTCCGGAAGAGTGGCTGGGTTCTGAGTGCCAAAGTCACACTGCCTGTTCCTTGTGGGTGGGAGCAGACCTGGAGGGGCCACAGCCCAGCCATCCTTCCACACAGCCCCCCAGGCAGCCCGTA...
TTAAAAACCTGTTTCGTGAGCCAGCTTTTTAGAAAGAAACGGGGCTGCCCCAACCTTGACCTGTTTTGTGTTCCAGGGAGAACGAGGCAAGCCGGGGCTCCCAGGAGAGAAGGGAGAAGCCGGAGATCCTGTGAGTGCCTGACTGTGGGGTGGGGGCCCTAAGAAGCTGGAGGCGGGGAACGACTAGGCCTCGGAAACTTCCGGAAGAGTGGCTGGGTTCTGAGTGCCAAAGTCACACTGCCTGTTCCTTGTGGGTGGGAGCAGACCTGGAGGGGCCACAGCCCAGCCATCCTTCCACACAGCCCCCCAGGCAGCCCGTA...
benign
320,676
Variant on chromosome 21, at position 45997444, affecting COL6A1 (collagen type VI alpha 1 chain): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Bethlem_myopathy_1A', 'COL6A1-related_disorder', 'likely other unspecified diseases']
GGCCATGCAGCCAGTGGCAGATTGTGGGGAGGGGACGGCCCAGGGCCACGTTCCAGGCTTGGGAGGCTGCTCCAGACCTTGGTAGCTGAAAGTCTCAGTGGGAATGAGCGTTCAGAGGCCAGGACTTGCTCGGAGAATTCTAACCACACCCTGCCTGTTTTATATGTTCAGTTTTCAAAGTAATCAATAGCCACTATAAGAAAAAAACAAAGCCACTTTCAAAGGGTTGTGGTAAGAGGCAGTCCTGTGAGCAGGCCGGCTGCAGGGCCTCCAGGGCTGTGGGGCAGGCTGCACAGGGGCTGGTGGGTCCCATGCCTGGG...
GGCCATGCAGCCAGTGGCAGATTGTGGGGAGGGGACGGCCCAGGGCCACGTTCCAGGCTTGGGAGGCTGCTCCAGACCTTGGTAGCTGAAAGTCTCAGTGGGAATGAGCGTTCAGAGGCCAGGACTTGCTCGGAGAATTCTAACCACACCCTGCCTGTTTTATATGTTCAGTTTTCAAAGTAATCAATAGCCACTATAAGAAAAAAACAAAGCCACTTTCAAAGGGTTGTGGTAAGAGGCAGTCCTGTGAGCAGGCCGGCTGCAGGGCCTCCAGGGCTGTGGGGCAGGCTGCACAGGGGCTGGTGGGTCCCATGCCTGGG...
pathogenic
320,708
Mutation at chromosome 21, position 45997518, within COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? If pathogenic, indicate the disease(s).
benign
GACCTTGGTAGCTGAAAGTCTCAGTGGGAATGAGCGTTCAGAGGCCAGGACTTGCTCGGAGAATTCTAACCACACCCTGCCTGTTTTATATGTTCAGTTTTCAAAGTAATCAATAGCCACTATAAGAAAAAAACAAAGCCACTTTCAAAGGGTTGTGGTAAGAGGCAGTCCTGTGAGCAGGCCGGCTGCAGGGCCTCCAGGGCTGTGGGGCAGGCTGCACAGGGGCTGGTGGGTCCCATGCCTGGGGGTCTGGGAATAGTCTCTAGGCTGCTGTCCTGGAGGAGGTTTCCCCCAACGCCTGAGACCAGGGCACCATGTGA...
GACCTTGGTAGCTGAAAGTCTCAGTGGGAATGAGCGTTCAGAGGCCAGGACTTGCTCGGAGAATTCTAACCACACCCTGCCTGTTTTATATGTTCAGTTTTCAAAGTAATCAATAGCCACTATAAGAAAAAAACAAAGCCACTTTCAAAGGGTTGTGGTAAGAGGCAGTCCTGTGAGCAGGCCGGCTGCAGGGCCTCCAGGGCTGTGGGGCAGGCTGCACAGGGGCTGGTGGGTCCCATGCCTGGGGGTCTGGGAATAGTCTCTAGGCTGCTGTCCTGGAGGAGGTTTCCCCCAACGCCTGAGACCAGGGCACCATGTGA...
benign
320,711
Evaluate this variant at chromosome 21, position 45998395, gene COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Bethlem_myopathy_1A']
TGCTGGGGCGTTGACCACGAAGGGTGCAGGAGCTTCACAGCCAGGCCTGGGTGCTTGCACAGTCGGGGTAGAGAGAGCAATACACTAGATGCCTCCTGTCTGCCTGGTGGAGGCCACGGGGTCAGGATGGTGAATGGGCCAAGTCTGGTAGTGGGGAAGTTGTAAACATTTGAACCACCGGACAGGCCTCATCGGGAAGCATCAGCCTAACCACAGGCCAGGGACAGGCGTCTGAGCAGGCACAGGCCAGGGACAGGCGTCCGACCAGGCTCATGGCTGGGGCCAGGTGGGCCAGGTGGGCCAGGTGGGCCGGGCGATGT...
TGCTGGGGCGTTGACCACGAAGGGTGCAGGAGCTTCACAGCCAGGCCTGGGTGCTTGCACAGTCGGGGTAGAGAGAGCAATACACTAGATGCCTCCTGTCTGCCTGGTGGAGGCCACGGGGTCAGGATGGTGAATGGGCCAAGTCTGGTAGTGGGGAAGTTGTAAACATTTGAACCACCGGACAGGCCTCATCGGGAAGCATCAGCCTAACCACAGGCCAGGGACAGGCGTCTGAGCAGGCACAGGCCAGGGACAGGCGTCCGACCAGGCTCATGGCTGGGGCCAGGTGGGCCAGGTGGGCCAGGTGGGCCGGGCGATGT...
pathogenic
320,724
Is the genetic variant on chromosome 21, position 45998922, gene COL6A1 (collagen type VI alpha 1 chain), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Ullrich_congenital_muscular_dystrophy_1A']
GTGCAGGTGGGGGCAGGGTGGTGTCCAGGCTCAGCCCACAGAGGGTCCTGCGGTTGGGGGTGGGCTAAGGGGACCAGGCCAGGCCCAAAGGGGACCATGAGGGAGGGCAGTCTGGGGCCACTCTGATAGGAGAAGGGGCAGGTGGTCTGCGGCCTGGGGACCTGTAGCCTCACCCCTCCGTGGGGACCTGAGGCACCAGCCGGGCACTCACCGAAGTCATCTGGGACAGGCTTCACCCTTCCGTGGGGGCCTGAGGCACCAGCCGGGCGCCCACCAAAGTCATCTGGGAGAGGCTTCACCCCTCCGTGGGGGCCTGAGGC...
GTGCAGGTGGGGGCAGGGTGGTGTCCAGGCTCAGCCCACAGAGGGTCCTGCGGTTGGGGGTGGGCTAAGGGGACCAGGCCAGGCCCAAAGGGGACCATGAGGGAGGGCAGTCTGGGGCCACTCTGATAGGAGAAGGGGCAGGTGGTCTGCGGCCTGGGGACCTGTAGCCTCACCCCTCCGTGGGGACCTGAGGCACCAGCCGGGCACTCACCGAAGTCATCTGGGACAGGCTTCACCCTTCCGTGGGGGCCTGAGGCACCAGCCGGGCGCCCACCAAAGTCATCTGGGAGAGGCTTCACCCCTCCGTGGGGGCCTGAGGC...
pathogenic
320,734
Gene mutation in COL6A1 (collagen type VI alpha 1 chain) at chromosome 21, position 46002345—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Bethlem_myopathy_1A', 'COL6A1-related_disorder']
TATGGCCCCAGTACCCTCGTCTCTCCCTCCCCAGGAATGCGAGATTTTGGACATCATCATGAAAATGTGCTGTGAGTATCTCTGAGAAGCCGTCCTCGTTAGGGAGAGCAGGGCCGCCAGCCTGGCCTGTTCCACTCCTAGAAGGGTGTCTCCACTGTTGGGGGCCTGGGTCTCTGGGTACATCCTTGAGGAGGCTCCTCAGCCAGCCCCTACCGGCCTCCAAAGCCCTCCCAGGCCCCCGGGTCCCCGCACAGGCTGAGAGTCCCCGGTGCGGTGCAGAGCTGCCACGTGGGGAGGGCGGCCGGGGAGGCGGGGAGGCG...
TATGGCCCCAGTACCCTCGTCTCTCCCTCCCCAGGAATGCGAGATTTTGGACATCATCATGAAAATGTGCTGTGAGTATCTCTGAGAAGCCGTCCTCGTTAGGGAGAGCAGGGCCGCCAGCCTGGCCTGTTCCACTCCTAGAAGGGTGTCTCCACTGTTGGGGGCCTGGGTCTCTGGGTACATCCTTGAGGAGGCTCCTCAGCCAGCCCCTACCGGCCTCCAAAGCCCTCCCAGGCCCCCGGGTCCCCGCACAGGCTGAGAGTCCCCGGTGCGGTGCAGAGCTGCCACGTGGGGAGGGCGGCCGGGGAGGCGGGGAGGCG...
pathogenic
320,792
Variant chromosome 21, position 46002718, gene COL6A1 (collagen type VI alpha 1 chain): benign or pathogenic? Disease(s)?
benign
CGGGGAGGCTGCCCCAAGAGTAAAAGCCTTTCTGACGTGCGCAGGACGCGGCCCTGACTGGTCTAACTGACTCTTTCTCTTCTCCTCAGCTTGCTGTGGTGAGACCCAGGCTCTAGCTCCTGAGAGAATGGATCCCGGGGGTCGGGGAGCGAGGCCTGGGTCCCACACATGTCACAGGACAGCACATGGCACTCTGGTCCCCGCCCGCAGCTCCCTGCACCTGCCCGCCCCCTCTGGGGCCTGCTCCAAGCCAGCAGGGTTCCCGGGTGTTGGGCTGGGCCCCGCCCTCTTTCACCCATAACTGAAATAACCAGGAGCAG...
CGGGGAGGCTGCCCCAAGAGTAAAAGCCTTTCTGACGTGCGCAGGACGCGGCCCTGACTGGTCTAACTGACTCTTTCTCTTCTCCTCAGCTTGCTGTGGTGAGACCCAGGCTCTAGCTCCTGAGAGAATGGATCCCGGGGGTCGGGGAGCGAGGCCTGGGTCCCACACATGTCACAGGACAGCACATGGCACTCTGGTCCCCGCCCGCAGCTCCCTGCACCTGCCCGCCCCCTCTGGGGCCTGCTCCAAGCCAGCAGGGTTCCCGGGTGTTGGGCTGGGCCCCGCCCTCTTTCACCCATAACTGAAATAACCAGGAGCAG...
benign
320,799
Gene COL6A2 (collagen type VI alpha 2 chain) variant at chromosome 21, position 46115897—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Bethlem_myopathy_1A']
ATGTCTCACAGCTCCCTCACGCCCGCCCAGGTTCTCAGGGCATTTCAGCATCTCCTTGGCCCCTGCTGAGAGTCGTGGGCTACACGTTCTGAGACCCTGCCCTGCCACCTGAGGAATGTCCCACCCATGCAACCTTCTGTCTCTGCTTCCTCGTTTCAGTGCTACAAGGTGAGCTGCCTGGAAATCCCTGGGCCCTCTGGCCCCAAGGGCTACCGTGGACAGAAGGTAAGATGCCCAGATTACCTGCAGGGTCTGCGCTACCAGGAAGCCCCTGATTTGTTTTGAAATCCACACTTGGCCGGGCGTGGTGGCTCATACCT...
ATGTCTCACAGCTCCCTCACGCCCGCCCAGGTTCTCAGGGCATTTCAGCATCTCCTTGGCCCCTGCTGAGAGTCGTGGGCTACACGTTCTGAGACCCTGCCCTGCCACCTGAGGAATGTCCCACCCATGCAACCTTCTGTCTCTGCTTCCTCGTTTCAGTGCTACAAGGTGAGCTGCCTGGAAATCCCTGGGCCCTCTGGCCCCAAGGGCTACCGTGGACAGAAGGTAAGATGCCCAGATTACCTGCAGGGTCTGCGCTACCAGGAAGCCCCTGATTTGTTTTGAAATCCACACTTGGCCGGGCGTGGTGGCTCATACCT...
pathogenic
320,893
Variant chromosome 21, position 46116767, gene COL6A2 (collagen type VI alpha 2 chain): benign or pathogenic? Disease(s)?
pathogenic; ['Bethlem_myopathy_1A', 'COL6A2-related_disorder']
TTTGAATGTCCCCTGCATTTTCTGGTTTGAACATCCCCTGCATTTTCCTAACAGAGGTGCATCAAATAAAGTCCTTCCAAAACTCACTAACAGAGTATGTGAAACTCCAACAATTCACATCTGTTAAAAATTATAAAGAAAAGCATAGGAGGAGAAAGTAGCTTCTAAGGAGATGAAATAAGGAATTGACCATCATAGAGGATGTTACTGCTACGTAGCTTCGTGTTTTTCTAAATTTGGATAACAGCTGTCTAGACCAGTAGGTATCTGGATGTACTTTCTCCAGGATGAGACATCTCGAGGCTGCAGGTCAAATCCTG...
TTTGAATGTCCCCTGCATTTTCTGGTTTGAACATCCCCTGCATTTTCCTAACAGAGGTGCATCAAATAAAGTCCTTCCAAAACTCACTAACAGAGTATGTGAAACTCCAACAATTCACATCTGTTAAAAATTATAAAGAAAAGCATAGGAGGAGAAAGTAGCTTCTAAGGAGATGAAATAAGGAATTGACCATCATAGAGGATGTTACTGCTACGTAGCTTCGTGTTTTTCTAAATTTGGATAACAGCTGTCTAGACCAGTAGGTATCTGGATGTACTTTCTCCAGGATGAGACATCTCGAGGCTGCAGGTCAAATCCTG...
pathogenic
320,920
Determine if the mutation at chromosome 21, position 46121557 in gene COL6A2 (collagen type VI alpha 2 chain) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Bethlem_myopathy_1A', 'Ullrich_congenital_muscular_dystrophy_1A']
GCCACTCACCAGACATCCAACTCCACCTGGAGCCTCCCCAGATCATTCCTAAATCCTCGGCATGGGCGGGACCGACGCAGCAGAGGGACGAGGGCTGGCAGCAGAGCCACTGGCGCAGGCTGAGGCTGTTGGGAAGGAGCCTGGGGATCGAGGTCCCAGGTCCCAAAGCCAGAGCCCTCCTGTAGAGAAGGAGCATCGGCCCCGGCACAGCCCCCACCCTCCACAGGCTCTGGGCTTGGACTCAGCCCCCTCCCTCACCCACACGCCTGTTCTCTGCAGGGGCGCAGGGGAGACCCCGGCACCAAGGGCAGCCCAGGCAG...
GCCACTCACCAGACATCCAACTCCACCTGGAGCCTCCCCAGATCATTCCTAAATCCTCGGCATGGGCGGGACCGACGCAGCAGAGGGACGAGGGCTGGCAGCAGAGCCACTGGCGCAGGCTGAGGCTGTTGGGAAGGAGCCTGGGGATCGAGGTCCCAGGTCCCAAAGCCAGAGCCCTCCTGTAGAGAAGGAGCATCGGCCCCGGCACAGCCCCCACCCTCCACAGGCTCTGGGCTTGGACTCAGCCCCCTCCCTCACCCACACGCCTGTTCTCTGCAGGGGCGCAGGGGAGACCCCGGCACCAAGGGCAGCCCAGGCAG...
pathogenic
320,968
Variant chromosome 21, position 46124895, gene COL6A2 (collagen type VI alpha 2 chain): benign or pathogenic? Disease(s)?
pathogenic; ['Bethlem_myopathy_1A']
CCAGGCTAACATGTGTTCCCTGTCACAGGGAGGCCGAGGCGACTTTGGCTTGAAAGGAGAACCTGGGAGGAAAGGAGAGAAAGGAGAGCCTGTGAGTGTCACCGTCCCGAAGCCCACAGCAGCTGGGCAGAGGCAGGGAGGGGCCCTGAGGCTGAGCGTGTGCATCTATGAGTACAGGAGAACGCCAGGCAGCTTGGCCCCAGCCATGAGCACCACCCCCACCTTCCTAAAGGGAACGGCTGGCTCAGGGGCCCCCTCCCTCAACCCAGCCTCCCTTCCAGCGTCCCCTCCCCAGTGACCCCCCAACATCCCCCCCACAG...
CCAGGCTAACATGTGTTCCCTGTCACAGGGAGGCCGAGGCGACTTTGGCTTGAAAGGAGAACCTGGGAGGAAAGGAGAGAAAGGAGAGCCTGTGAGTGTCACCGTCCCGAAGCCCACAGCAGCTGGGCAGAGGCAGGGAGGGGCCCTGAGGCTGAGCGTGTGCATCTATGAGTACAGGAGAACGCCAGGCAGCTTGGCCCCAGCCATGAGCACCACCCCCACCTTCCTAAAGGGAACGGCTGGCTCAGGGGCCCCCTCCCTCAACCCAGCCTCCCTTCCAGCGTCCCCTCCCCAGTGACCCCCCAACATCCCCCCCACAG...
pathogenic
321,000
Variant in COL6A2 (collagen type VI alpha 2 chain), chromosome 21, position 46124919—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Bethlem_myopathy_1A', 'COL6A2-related_disorder']
ACAGGGAGGCCGAGGCGACTTTGGCTTGAAAGGAGAACCTGGGAGGAAAGGAGAGAAAGGAGAGCCTGTGAGTGTCACCGTCCCGAAGCCCACAGCAGCTGGGCAGAGGCAGGGAGGGGCCCTGAGGCTGAGCGTGTGCATCTATGAGTACAGGAGAACGCCAGGCAGCTTGGCCCCAGCCATGAGCACCACCCCCACCTTCCTAAAGGGAACGGCTGGCTCAGGGGCCCCCTCCCTCAACCCAGCCTCCCTTCCAGCGTCCCCTCCCCAGTGACCCCCCAACATCCCCCCCACAGCATCCCCCACAAGGGTCCCCTCCC...
ACAGGGAGGCCGAGGCGACTTTGGCTTGAAAGGAGAACCTGGGAGGAAAGGAGAGAAAGGAGAGCCTGTGAGTGTCACCGTCCCGAAGCCCACAGCAGCTGGGCAGAGGCAGGGAGGGGCCCTGAGGCTGAGCGTGTGCATCTATGAGTACAGGAGAACGCCAGGCAGCTTGGCCCCAGCCATGAGCACCACCCCCACCTTCCTAAAGGGAACGGCTGGCTCAGGGGCCCCCTCCCTCAACCCAGCCTCCCTTCCAGCGTCCCCTCCCCAGTGACCCCCCAACATCCCCCCCACAGCATCCCCCACAAGGGTCCCCTCCC...
pathogenic
321,002
Is the genetic mutation found on chromosome 21 at position 46125327, within the gene COL6A2 (collagen type VI alpha 2 chain), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
CAACATAGCATCCCCTCCAGAGTCCCCTCCCCCAAAAGATGCCTCCACATAGCATCCCCCTCAGAGTTCCTACACACAGCATTCCCCAAGGGTTCCCTCCCCAATGTCCTCCCCACAGTTATCCCCCAGAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGA...
CAACATAGCATCCCCTCCAGAGTCCCCTCCCCCAAAAGATGCCTCCACATAGCATCCCCCTCAGAGTTCCTACACACAGCATTCCCCAAGGGTTCCCTCCCCAATGTCCTCCCCACAGTTATCCCCCAGAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGA...
benign
321,009
Benign or pathogenic: chromosome 21, position 46125455, gene COL6A2 (collagen type VI alpha 2 chain) variant? Disease(s) if pathogenic?
benign
GAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGAAGATGGATGAATGGATGGATTGCTGGATGAGTGGGTGGGTGGATGGATAAGTGGATACATGGGTGAATGAGTAGATGTATGGGTGAGTAGGTGGGTAGGTGGGTAGATGGATGGGTGGGTGGGCGAGT...
GAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGAAGATGGATGAATGGATGGATTGCTGGATGAGTGGGTGGGTGGATGGATAAGTGGATACATGGGTGAATGAGTAGATGTATGGGTGAGTAGGTGGGTAGGTGGGTAGATGGATGGGTGGGTGGGCGAGT...
benign
321,012
Determine if the mutation at chromosome 21, position 46125455 in gene COL6A2 (collagen type VI alpha 2 chain) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
GAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGAAGATGGATGAATGGATGGATTGCTGGATGAGTGGGTGGGTGGATGGATAAGTGGATACATGGGTGAATGAGTAGATGTATGGGTGAGTAGGTGGGTAGGTGGGTAGATGGATGGGTGGGTGGGCGAGT...
GAAGGTGCTCTGTGCCTCCAAATCCCTAGCCTGGCCAAGGGTTTAACCAGGGCTGCAGGTTGGTCTGGAACTGAGCACAAAACAAGGGATGGATAACGATGGATGGATGGGCAAGTGGATGGGGGTGGGCAAATGGATGGATGGGAGGATGGGTGATGGATGGATGAGTGAATAGAAGAGTGGGTGGATAGAAGATGGATGAATGGATGGATTGCTGGATGAGTGGGTGGGTGGATGGATAAGTGGATACATGGGTGAATGAGTAGATGTATGGGTGAGTAGGTGGGTAGGTGGGTAGATGGATGGGTGGGTGGGCGAGT...
benign
321,013
Variant at chromosome position 46126116, chromosome 21, gene COL6A2 (collagen type VI alpha 2 chain): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Bethlem_myopathy_1A', 'Ullrich_congenital_muscular_dystrophy_1A']
ACCGATGGATGAATGGGTGGGTGGGTAGAGGATGGACGGACAGGTGAGTGGGTGGGTGGATGGATAGATGGGTAAGTGAGTGGATAGATAGATGGGTGGGTGGACAGAGGATGGGTGGATGAATGGATGGGTTAGTGGGTGGCTGGGTGGATGGATGATGGATGGGTGACTGGGTGGATGGATGGATGGGTTAGTGGGTGGCTGGGTGGATAGATGGATGGGTGATTGGGCGAATGGGCGAATGGGTGGATGGGTGGGCGTGGAGTTGGTGGGTACATGATAATGGGGTGGAATACCCATGGATTGGAATGAGCTGTTTT...
ACCGATGGATGAATGGGTGGGTGGGTAGAGGATGGACGGACAGGTGAGTGGGTGGGTGGATGGATAGATGGGTAAGTGAGTGGATAGATAGATGGGTGGGTGGACAGAGGATGGGTGGATGAATGGATGGGTTAGTGGGTGGCTGGGTGGATGGATGATGGATGGGTGACTGGGTGGATGGATGGATGGGTTAGTGGGTGGCTGGGTGGATAGATGGATGGGTGATTGGGCGAATGGGCGAATGGGTGGATGGGTGGGCGTGGAGTTGGTGGGTACATGATAATGGGGTGGAATACCCATGGATTGGAATGAGCTGTTTT...
pathogenic
321,034
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 21, position 46126123, gene COL6A2 (collagen type VI alpha 2 chain). What disease(s) is it linked to if pathogenic?
pathogenic; ['Bethlem_myopathy_1A']
GATGAATGGGTGGGTGGGTAGAGGATGGACGGACAGGTGAGTGGGTGGGTGGATGGATAGATGGGTAAGTGAGTGGATAGATAGATGGGTGGGTGGACAGAGGATGGGTGGATGAATGGATGGGTTAGTGGGTGGCTGGGTGGATGGATGATGGATGGGTGACTGGGTGGATGGATGGATGGGTTAGTGGGTGGCTGGGTGGATAGATGGATGGGTGATTGGGCGAATGGGCGAATGGGTGGATGGGTGGGCGTGGAGTTGGTGGGTACATGATAATGGGGTGGAATACCCATGGATTGGAATGAGCTGTTTTGGCTGCT...
GATGAATGGGTGGGTGGGTAGAGGATGGACGGACAGGTGAGTGGGTGGGTGGATGGATAGATGGGTAAGTGAGTGGATAGATAGATGGGTGGGTGGACAGAGGATGGGTGGATGAATGGATGGGTTAGTGGGTGGCTGGGTGGATGGATGATGGATGGGTGACTGGGTGGATGGATGGATGGGTTAGTGGGTGGCTGGGTGGATAGATGGATGGGTGATTGGGCGAATGGGCGAATGGGTGGATGGGTGGGCGTGGAGTTGGTGGGTACATGATAATGGGGTGGAATACCCATGGATTGGAATGAGCTGTTTTGGCTGCT...
pathogenic
321,035
Evaluate if the mutation on chromosome 21 at position 46126476 in COL6A2 (collagen type VI alpha 2 chain) is benign or pathogenic. Disease name(s) if pathogenic?
benign
CCCCTCTGGTGGGCCAGGCTCTGACGGTGGCCACTCATGGCCTTTCTAGCTCTGGTGCCAGCATAGGGAAGGAGGAGGCACAGCCTTGTCTTACTCCTTGCACCTGTTAGCCCCCCCCCCCGCCAAGGGAGGACCCGTGGTTGGGGACAGCACAGGGGGCCCTGCTGTGTGCAGGGACTGTCCCTGGGGCCACTGAAGCCCACCTGTTCTTGTTCCTTCTCAGGCGGATCCTGGTCCCCCTGGTGAGCCAGGCCCTCGGGGGCCAAGAGGAGTCCCAGGACCCGAGGTAGGTTGGTGGCCAGTCCCCATGCCCTCCCCCC...
CCCCTCTGGTGGGCCAGGCTCTGACGGTGGCCACTCATGGCCTTTCTAGCTCTGGTGCCAGCATAGGGAAGGAGGAGGCACAGCCTTGTCTTACTCCTTGCACCTGTTAGCCCCCCCCCCCGCCAAGGGAGGACCCGTGGTTGGGGACAGCACAGGGGGCCCTGCTGTGTGCAGGGACTGTCCCTGGGGCCACTGAAGCCCACCTGTTCTTGTTCCTTCTCAGGCGGATCCTGGTCCCCCTGGTGAGCCAGGCCCTCGGGGGCCAAGAGGAGTCCCAGGACCCGAGGTAGGTTGGTGGCCAGTCCCCATGCCCTCCCCCC...
benign
321,046
Does the variant on chromosome 21 at location 46131945 affecting gene COL6A2 (collagen type VI alpha 2 chain) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
CAGCTGGGCTGCCGTGCGTCTGGGATGGGGCTGAGGGAGGGTGCTGCCCAGGTGCTGGAGGATGTTCCAGCACCAGGTTCCAGCGGAGCCTCGGAAACAGGCCCCAGAGGCTGGTGAGCCTCGCTGGGTGTGGGCACTAATCCCGTGCATGGTGACTCGTGGGCGCTCACGGCCCACCTGGTGGCAGGTGAAGGCTTCCGGTTGGGCAGCAGATAGTCCTGGGGGAAGCTGGCAGTCCTGGCACCATGACGTATCTGGGCTGGTGTCATGCACAGTAGGGCGAATGGCCACAGCTGCCTGCCAGCAGCCCTGATCCCGGG...
CAGCTGGGCTGCCGTGCGTCTGGGATGGGGCTGAGGGAGGGTGCTGCCCAGGTGCTGGAGGATGTTCCAGCACCAGGTTCCAGCGGAGCCTCGGAAACAGGCCCCAGAGGCTGGTGAGCCTCGCTGGGTGTGGGCACTAATCCCGTGCATGGTGACTCGTGGGCGCTCACGGCCCACCTGGTGGCAGGTGAAGGCTTCCGGTTGGGCAGCAGATAGTCCTGGGGGAAGCTGGCAGTCCTGGCACCATGACGTATCTGGGCTGGTGTCATGCACAGTAGGGCGAATGGCCACAGCTGCCTGCCAGCAGCCCTGATCCCGGG...
benign
321,063
The mutation in gene FTCD (formimidoyltransferase cyclodeaminase) at chromosome 21, position 46138498—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
GAGGCTATCCTTCCAGCGTCGAAGGTCCTGCTGTCCCTGGGGTTTCTGTCCCATGCACAGAACCAGGGCCCCTTTCCCTCAGACAAGGGGCCTCACAGCCCAGGGACCTGCACTGAACCCCAGGTCCTCTGAATACCTGTGACCCTGCCCACTGTGGGCTGCACTGGGTGTCTGGGGACCCTGGCGCTGAGGTCTGTCTCCTCACGCTGCAACCCCATTCCCTCCAACCCTGGCTCCCATGGGCCACTGACCATATGTCCTGCTCCTGCCCCAAGACCCGCAGCTCAGCTCTCAGCCCTGCCCCCAAAACCGCCAACACA...
GAGGCTATCCTTCCAGCGTCGAAGGTCCTGCTGTCCCTGGGGTTTCTGTCCCATGCACAGAACCAGGGCCCCTTTCCCTCAGACAAGGGGCCTCACAGCCCAGGGACCTGCACTGAACCCCAGGTCCTCTGAATACCTGTGACCCTGCCCACTGTGGGCTGCACTGGGTGTCTGGGGACCCTGGCGCTGAGGTCTGTCTCCTCACGCTGCAACCCCATTCCCTCCAACCCTGGCTCCCATGGGCCACTGACCATATGTCCTGCTCCTGCCCCAAGACCCGCAGCTCAGCTCTCAGCCCTGCCCCCAAAACCGCCAACACA...
benign
321,110
Chromosome 21, position 46145854, gene FTCD (formimidoyltransferase cyclodeaminase): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Glutamate_formiminotransferase_deficiency']
TCTCCCTTTCTCCAGGGGAGTTTGAAGAAGACTCTGGTCCACCACCTCTTGTAAAGGGCCCACCCGCAGTTATCCCGAGGCCTAATCGTCTCCCTGTGATGCTGTGCTTTAGAGCTCATGCTCCTGTTTCACTTTTATGTTCCACTCTGTACACCTGGCTCCGCCCTCTAGATAACAGTAGCAAACTTAGTAAAAGTATTAGTCTTTAATCTTTCTAAAAAGAGGATTAAAAAAAATGATGTGAGCTGTCCTCTCTCTCTCTGCCTCAGCTACCTAACAGGGAAGGGGCCCCTGTGCGGTGGACATGTGACTCACGTGAC...
TCTCCCTTTCTCCAGGGGAGTTTGAAGAAGACTCTGGTCCACCACCTCTTGTAAAGGGCCCACCCGCAGTTATCCCGAGGCCTAATCGTCTCCCTGTGATGCTGTGCTTTAGAGCTCATGCTCCTGTTTCACTTTTATGTTCCACTCTGTACACCTGGCTCCGCCCTCTAGATAACAGTAGCAAACTTAGTAAAAGTATTAGTCTTTAATCTTTCTAAAAAGAGGATTAAAAAAAATGATGTGAGCTGTCCTCTCTCTCTCTGCCTCAGCTACCTAACAGGGAAGGGGCCCCTGTGCGGTGGACATGTGACTCACGTGAC...
pathogenic
321,117
Mutation found at chromosome 21 position 46145925, gene FTCD (formimidoyltransferase cyclodeaminase): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['FTCD-related_disorder', 'Glutamate_formiminotransferase_deficiency', 'Inborn_genetic_diseases']
ATCCCGAGGCCTAATCGTCTCCCTGTGATGCTGTGCTTTAGAGCTCATGCTCCTGTTTCACTTTTATGTTCCACTCTGTACACCTGGCTCCGCCCTCTAGATAACAGTAGCAAACTTAGTAAAAGTATTAGTCTTTAATCTTTCTAAAAAGAGGATTAAAAAAAATGATGTGAGCTGTCCTCTCTCTCTCTGCCTCAGCTACCTAACAGGGAAGGGGCCCCTGTGCGGTGGACATGTGACTCACGTGACCTTATCAATCATTAAAGATGACTCACACTCTTTACCCTGCCTCTTTTGCTTTGTATCCAATAAATAACAGC...
ATCCCGAGGCCTAATCGTCTCCCTGTGATGCTGTGCTTTAGAGCTCATGCTCCTGTTTCACTTTTATGTTCCACTCTGTACACCTGGCTCCGCCCTCTAGATAACAGTAGCAAACTTAGTAAAAGTATTAGTCTTTAATCTTTCTAAAAAGAGGATTAAAAAAAATGATGTGAGCTGTCCTCTCTCTCTCTGCCTCAGCTACCTAACAGGGAAGGGGCCCCTGTGCGGTGGACATGTGACTCACGTGACCTTATCAATCATTAAAGATGACTCACACTCTTTACCCTGCCTCTTTTGCTTTGTATCCAATAAATAACAGC...
pathogenic
321,119
Gene FTCD (formimidoyltransferase cyclodeaminase) variant at chromosome 21, position 46152980—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Glutamate_formiminotransferase_deficiency']
GACTCTGACCTCTGCCCTTGGCCGGGGCCTAAAGCAGGACTTAGAGGTCCCTGTGCTTTTGTGCTGAGTCTGCAGGTCGGGAAGCCGGGTCCCAGGACCTTGGCTGTTTGTGGGACCGGGGTCTCTGAGTGGGGAACAGATGGGCAGGTGGTCCCCCCCGCTTTCTCCGGGTATCTATACCCGGAGTGACGCTCAGACCGGGTGACCACTGCTGTGCAGACGTGGAGGGAAAGGCCTGGGGGCACCTGAAGGTTTGTAGGGGTGTCGGGGCTCCCAAGGCATCTGGAGGGATATGGGGGGCCCCTGAGGGCACCTGGGAC...
GACTCTGACCTCTGCCCTTGGCCGGGGCCTAAAGCAGGACTTAGAGGTCCCTGTGCTTTTGTGCTGAGTCTGCAGGTCGGGAAGCCGGGTCCCAGGACCTTGGCTGTTTGTGGGACCGGGGTCTCTGAGTGGGGAACAGATGGGCAGGTGGTCCCCCCCGCTTTCTCCGGGTATCTATACCCGGAGTGACGCTCAGACCGGGTGACCACTGCTGTGCAGACGTGGAGGGAAAGGCCTGGGGGCACCTGAAGGTTTGTAGGGGTGTCGGGGCTCCCAAGGCATCTGGAGGGATATGGGGGGCCCCTGAGGGCACCTGGGAC...
pathogenic
321,132
Determine if the mutation at chromosome 21, position 46154202 in gene FTCD (formimidoyltransferase cyclodeaminase) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Glutamate_formiminotransferase_deficiency']
ACCCTCAGTGTGGGCCAGCACCCCTGCCCACCCCCTCCTCAGAGGGCCCTGAAAAGGCGAATTGCAGGGTTAGGATGGAACATGTGGGACATGCTAACGGCAGGACGTTCATGCTTCTGTTTTCTTTGTATGATAAACAGAACCGCAAGCAACCACATAAATATAACGGCAGAGAAGAGGAAAAACTCGTGAACCCGCACACCAGTGTGACTGTGACGTGGGCCCTGCGTCGGGATTTCCTTCGGGGGGACTGGCATGACCGTGACGGGGGTTACGTGTGCCCTGCATGCCGGCGTGACCGTGACGGGGGTTACGTGTGC...
ACCCTCAGTGTGGGCCAGCACCCCTGCCCACCCCCTCCTCAGAGGGCCCTGAAAAGGCGAATTGCAGGGTTAGGATGGAACATGTGGGACATGCTAACGGCAGGACGTTCATGCTTCTGTTTTCTTTGTATGATAAACAGAACCGCAAGCAACCACATAAATATAACGGCAGAGAAGAGGAAAAACTCGTGAACCCGCACACCAGTGTGACTGTGACGTGGGCCCTGCGTCGGGATTTCCTTCGGGGGGACTGGCATGACCGTGACGGGGGTTACGTGTGCCCTGCATGCCGGCGTGACCGTGACGGGGGTTACGTGTGC...
pathogenic
321,136
Chromosome 21, position 46245202, gene MCM3AP: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
CATCACTCAAAGTCCAGACAAGCTTACATCGAGACTGGCAGGGCCAGTAATGACTACTCAAAAGCCACAAAATCCTCTCTAAGAGCCATCCTAGGGGGCCTGTTTCAGGGAGGTGAGTTCAGGCTCTACCAGAAACTTCCTAGCCTGTCTCAATGTTTTTAAGTCACTCACTTGAAGAGGGAAGTCCTAAGGAAAGGAAGGATAGAGACCCAAAAGAAAAGCAGCAACATCAACTAAACATCTTCCTTTGCAGAAACTGGACCAGGAAAGTCTCGTGAGGAGCTGATCCCATTGCATCAAGCTCTAATTACCTGATGTAA...
CATCACTCAAAGTCCAGACAAGCTTACATCGAGACTGGCAGGGCCAGTAATGACTACTCAAAAGCCACAAAATCCTCTCTAAGAGCCATCCTAGGGGGCCTGTTTCAGGGAGGTGAGTTCAGGCTCTACCAGAAACTTCCTAGCCTGTCTCAATGTTTTTAAGTCACTCACTTGAAGAGGGAAGTCCTAAGGAAAGGAAGGATAGAGACCCAAAAGAAAAGCAGCAACATCAACTAAACATCTTCCTTTGCAGAAACTGGACCAGGAAAGTCTCGTGAGGAGCTGATCCCATTGCATCAAGCTCTAATTACCTGATGTAA...
benign
321,230
The chromosome 21, position 46260896 genetic variant in gene MCM3AP (minichromosome maintenance complex component 3 associated protein): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Inborn_genetic_diseases', 'MCM3AP-related_disorder', 'Peripheral_neuropathy,_autosomal_recessive,_with_or_without_impaired_intellectual_development']
AATACAGAAACTAATAGCTCATATATTTTGAATTTGTTAAAAGACTCTTCCCCGTGTGTGTGGATTTTGCCTGTAGGAACACAGGACTCACCGCTGTAGATACTTGCAGAAGCACTGAAGCTCCTGGAGGGTCTCCTTTGCAGTCTGGAAGATTTCCTCCACGAGAAACAAGTCCACTAAGTGGGCACAGACATCCTCACAGCAACGGGCCACACGGACCCTCTGGTCTGTCTCTACTGCATTCCTAGAAACAGGGCAATCAGCATGGAAGACACTGCACTTGGGGCCCACAGACACTGAGGGCTTGCTTGAAAAGTGCA...
AATACAGAAACTAATAGCTCATATATTTTGAATTTGTTAAAAGACTCTTCCCCGTGTGTGTGGATTTTGCCTGTAGGAACACAGGACTCACCGCTGTAGATACTTGCAGAAGCACTGAAGCTCCTGGAGGGTCTCCTTTGCAGTCTGGAAGATTTCCTCCACGAGAAACAAGTCCACTAAGTGGGCACAGACATCCTCACAGCAACGGGCCACACGGACCCTCTGGTCTGTCTCTACTGCATTCCTAGAAACAGGGCAATCAGCATGGAAGACACTGCACTTGGGGCCCACAGACACTGAGGGCTTGCTTGAAAAGTGCA...
pathogenic
321,258
Is chromosome 21, position 46265326, gene MCM3AP (minichromosome maintenance complex component 3 associated protein) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Inborn_genetic_diseases']
CAAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAACAAAACAAAACAAACAAACAAAAAAACAATTTAACCTAGGAGGCAAAAACTTTATACGTTGAAAACTACAAAGCATTGTCGAAAGAAATTAAGAATGACCTAAATAAATGGAAAGACATCCCACATTCTCAGATTAGAAGATTTAATATTGTTAAGATGACAATACTGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGTACTTTAGGAGGCTGAGGCAGGTGGATCACTTGAGGCCAGGAGTTCGAGACCATCCCTGGAC...
CAAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAACAAAACAAAACAAACAAACAAAAAAACAATTTAACCTAGGAGGCAAAAACTTTATACGTTGAAAACTACAAAGCATTGTCGAAAGAAATTAAGAATGACCTAAATAAATGGAAAGACATCCCACATTCTCAGATTAGAAGATTTAATATTGTTAAGATGACAATACTGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGTACTTTAGGAGGCTGAGGCAGGTGGATCACTTGAGGCCAGGAGTTCGAGACCATCCCTGGAC...
pathogenic
321,263
Variant on chromosome 21, at position 46266018, affecting MCM3AP (minichromosome maintenance complex component 3 associated protein): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Inborn_genetic_diseases']
GGAAAATCTTCCTGACACTGTATCTGGCAATAACTTATTGGATTATGACTCCAAAAACGCAGGCAACTTTATGAGAGGAAACTTCTGGAGGACTGGGTGCAGCTCCCCGCAGCACGTAGCAGGAGGGGAGCACGAGATGCCACTCACCCCAGGGCGGCAGCTGCGTAGGCAGCACCCGCAGAGCCAACTTCCTCACAGTCCCTCTGCAGGGCCTCCTGGATGAGCTCGTCCACCACCTGCGCCAGGTCCTGTGGAGAGACCAGCATGGGGTGTAATGGAACGTCCCACCCAGGGCAGAAATGCTGGGTAACATGTTGTCA...
GGAAAATCTTCCTGACACTGTATCTGGCAATAACTTATTGGATTATGACTCCAAAAACGCAGGCAACTTTATGAGAGGAAACTTCTGGAGGACTGGGTGCAGCTCCCCGCAGCACGTAGCAGGAGGGGAGCACGAGATGCCACTCACCCCAGGGCGGCAGCTGCGTAGGCAGCACCCGCAGAGCCAACTTCCTCACAGTCCCTCTGCAGGGCCTCCTGGATGAGCTCGTCCACCACCTGCGCCAGGTCCTGTGGAGAGACCAGCATGGGGTGTAATGGAACGTCCCACCCAGGGCAGAAATGCTGGGTAACATGTTGTCA...
pathogenic
321,268
Evaluate this variant at chromosome 21, position 46334525, gene PCNT (pericentrin): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
TGACACACAAACATTAGAAGTGTCCTCTTAAGGAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTT...
TGACACACAAACATTAGAAGTGTCCTCTTAAGGAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTT...
pathogenic
321,315
Does the chromosome 21 mutation at position 46334557 within gene PCNT (pericentrin) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
GAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAAT...
GAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAAT...
benign
321,316
The mutation in gene PCNT (pericentrin) at chromosome 21, position 46334557—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
GAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAAT...
GAAGTGGATGGTCCAGGTTCCTTTGAAGTGTGATCATTCATGTGAGCGGGCAGCTGATTGAGACTACTGTGTCCCCTTTTCGTCCCTCACTTCCTCTTGATTCTGAGAAGATTGATCTAGGGTATTGTCAAATGAAGACTTGTCTGAGATTTTATTTTCACGTCAGTTTTGCCATCATCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAAT...
benign
321,317
Determine if the mutation at chromosome 21, position 46334734 in gene PCNT (pericentrin) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
TCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAATCTGGGCACTGTGGCTCATGCCTGTATTGCCAGCATTTTGGGATGCTGAGGTGGGAGGATTGCTTGAGCCCAGGATTTTGAGGCCAGCTTTGGAACATAATGAACAGAGACCCTGTCTCTACAAAAAAATAAAAAATAAGCTGGGCACAGTGGCGCATGCCAGTAGTTCCAGCTACTC...
TCATTGGCCATGGGTGCTCTCTCTCTGCATTCATCTTGTGACTCATCTAATGATCCCGAAAAGTCGACACTGTCATGTTTCTTTGCTATTTTGGGAAGAAATTGAAATGTTCTTAGTGAATCATCTTGTTAAAGCAAGCTAATCTGGGCACTGTGGCTCATGCCTGTATTGCCAGCATTTTGGGATGCTGAGGTGGGAGGATTGCTTGAGCCCAGGATTTTGAGGCCAGCTTTGGAACATAATGAACAGAGACCCTGTCTCTACAAAAAAATAAAAAATAAGCTGGGCACAGTGGCGCATGCCAGTAGTTCCAGCTACTC...
pathogenic
321,322
The mutation in gene PCNT (pericentrin) at chromosome 21, position 46363456—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
AAGAATACACATTCTTAACCTTGTCTTTTATCAGTACAGTCTACTAAGAGTCACCATGATGCTGCGTTGTGTAAACTGTGACCTCTAACTGCACAGGTGCTTTTGTCACCTCCCCTTCGTCTTCTGTGCTGCAGTTTTCATAGACTAGACATCACATCCGCCTCCTGCAGTGTCAGGAGATTTGCTTTGGAAAACATGTGTTTGAAAGAAATTAAGAGGAAAAATGGCCTTATACTTGCCATTTCTGGTGCTCTTCATTTCTTCTTGAAGATCTGAGTGTTTGGCGTCATTCCCTTCAGCGTGAAGGATCTCCTTCAGCA...
AAGAATACACATTCTTAACCTTGTCTTTTATCAGTACAGTCTACTAAGAGTCACCATGATGCTGCGTTGTGTAAACTGTGACCTCTAACTGCACAGGTGCTTTTGTCACCTCCCCTTCGTCTTCTGTGCTGCAGTTTTCATAGACTAGACATCACATCCGCCTCCTGCAGTGTCAGGAGATTTGCTTTGGAAAACATGTGTTTGAAAGAAATTAAGAGGAAAAATGGCCTTATACTTGCCATTTCTGGTGCTCTTCATTTCTTCTTGAAGATCTGAGTGTTTGGCGTCATTCCCTTCAGCGTGAAGGATCTCCTTCAGCA...
pathogenic
321,359
Clinical significance of chromosome 21, position 46363671, gene PCNT (pericentrin): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['PCNT-related_disorder']
GAGGAAAAATGGCCTTATACTTGCCATTTCTGGTGCTCTTCATTTCTTCTTGAAGATCTGAGTGTTTGGCGTCATTCCCTTCAGCGTGAAGGATCTCCTTCAGCATCTCTTGCTGTGCTGCACACATTTTCTCCGTTTTTTGAAGTCTTTATTTTACCTTGATTCTTGAGGAGTATTTTTGTGGCATTAAAAAGTCTAAGGTGACAGGTTTCTTGTTCAGGATTTAAAGATGTTTAAAATCCTTCTCTGCAGATTTTATGATCTGTTTTGTCTTGGTGTTGGTTTCCATTGATTGTGTTTTCTCTTCAGCAGGGGTCACG...
GAGGAAAAATGGCCTTATACTTGCCATTTCTGGTGCTCTTCATTTCTTCTTGAAGATCTGAGTGTTTGGCGTCATTCCCTTCAGCGTGAAGGATCTCCTTCAGCATCTCTTGCTGTGCTGCACACATTTTCTCCGTTTTTTGAAGTCTTTATTTTACCTTGATTCTTGAGGAGTATTTTTGTGGCATTAAAAAGTCTAAGGTGACAGGTTTCTTGTTCAGGATTTAAAGATGTTTAAAATCCTTCTCTGCAGATTTTATGATCTGTTTTGTCTTGGTGTTGGTTTCCATTGATTGTGTTTTCTCTTCAGCAGGGGTCACG...
pathogenic
321,363
Regarding the variant at chromosome 21 and position 46366954, affecting gene PCNT (pericentrin): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
GGCTTCCAGGCGCAGAGGTGCCTGTGCCTCTTGCCATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTT...
GGCTTCCAGGCGCAGAGGTGCCTGTGCCTCTTGCCATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTT...
pathogenic
321,374
Variant in gene PCNT (pericentrin), located at chromosome 21 position 46366962: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
GGCGCAGAGGTGCCTGTGCCTCTTGCCATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTTCACTGCCG...
GGCGCAGAGGTGCCTGTGCCTCTTGCCATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTTCACTGCCG...
pathogenic
321,375
Considering the genetic mutation at chromosome 21, position 46366988, impacting PCNT (pericentrin): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
CATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTTCACTGCCGTGGGGTTCTATTCATTCACTCCCATG...
CATCCGTCCTGTGTCGCCAGTGCCCATTGGAGGCCTTGGCATTTTGCAGGACCCTCCAGCTCCAGGCTCTTTGGCCTCCTGATGGGAGCAGGTCCTTCTGTGAGGACTCTCCCTGCCTCTGTCTTTGGCCCTGAGTGCCGCCTGCACCTCCTTAATTCACTGCCACGGGGTTCTATTCACTTCCATGGGGTTCTATTCATTCACTGCCATGGGGGTTCTATTCATTCACTGCCATGGGGTTCTCCTCACTGCCGTGGGGTTCTATTCACTGCTGTGGGGTTCTGTTCACTGCCGTGGGGTTCTATTCATTCACTCCCATG...
pathogenic
321,377
For chromosome 21, position 46385939, gene PCNT (pericentrin): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
TTCAGTGGCAGAAGCGCATTCACAGTGTTGTGCGTTCAGTGGCAGAAGCGCATTCACAGTGTTGTATATTCAGTGGCGGAAGCGCATTCACCATGTTGTATATTCAGTGGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGATGGAAGCACATTCACAGTGCTGTGCATTCAGCAGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGATGGAAGCACATTCACAGTGCTGTGCATTCAGCAGCGGAAGCGCATTCACGGTGTTGTGCGTTCAGTGGCAGAAG...
TTCAGTGGCAGAAGCGCATTCACAGTGTTGTGCGTTCAGTGGCAGAAGCGCATTCACAGTGTTGTATATTCAGTGGCGGAAGCGCATTCACCATGTTGTATATTCAGTGGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGATGGAAGCACATTCACAGTGCTGTGCATTCAGCAGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGGCGGAAGCGCATTCACAGTGTTGTATATTCAGTGATGGAAGCACATTCACAGTGCTGTGCATTCAGCAGCGGAAGCGCATTCACGGTGTTGTGCGTTCAGTGGCAGAAG...
pathogenic
321,394
Evaluate if the mutation on chromosome 21 at position 46388870 in PCNT (pericentrin) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
CGGCACTGTGTTGCCAAACGCAGCCTCCCCTTGGTGCGCGTCCTCCCCGTCCCCTTGTGTGGGTCTTTGGCTGCTCCCATTGGCGTGTCCCCGCCCGAGGCCTCTGTGTCCTGCTGCTGCTCCCATCTGTGTGTCCCCGCTGAGGCTTCTGGGTCCAGCCACTGCTCCCGTCTGTCTGTCCCCGCCCCAGGCCTCTGAGTCCTGCTGCTGCTCCCGTCTTTGTGTCCCCACTCGAGGCCTCTGGGTTGTGCTGCTGTGTCCTGAAGCTCTGAACTGGTTTGGCTCTGCTCTGGAGACCACCCAGGGTCCGGAGACCAGGT...
CGGCACTGTGTTGCCAAACGCAGCCTCCCCTTGGTGCGCGTCCTCCCCGTCCCCTTGTGTGGGTCTTTGGCTGCTCCCATTGGCGTGTCCCCGCCCGAGGCCTCTGTGTCCTGCTGCTGCTCCCATCTGTGTGTCCCCGCTGAGGCTTCTGGGTCCAGCCACTGCTCCCGTCTGTCTGTCCCCGCCCCAGGCCTCTGAGTCCTGCTGCTGCTCCCGTCTTTGTGTCCCCACTCGAGGCCTCTGGGTTGTGCTGCTGTGTCCTGAAGCTCTGAACTGGTTTGGCTCTGCTCTGGAGACCACCCAGGGTCCGGAGACCAGGT...
pathogenic
321,401
Gene PCNT (pericentrin) variant at chromosome position 46411793 on chromosome 21: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II', 'PCNT-related_disorder']
GCCCACGCCCGGCTAATTTTTGTATTTTTACTAGAGACCAGGGTGCACCGTGTCGGCCAGGCTGATCTTGAACTCCTGTGCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAGCCACCGCGCCCGGCCTCAGTTCACTGATTTCAGGTTTTGGTGTTTTACATTTAGAGCTACCTTCGTATGCTGGCTCCAGTATTTTAACGTGATATATGCGTTGTGATTATGACCGTCTTCAGTGCGCACCCCTTGATTCCAGTTTATTTAGTGCATTTAGGGAATGAGCAGAAGCTGCGTATAATC...
GCCCACGCCCGGCTAATTTTTGTATTTTTACTAGAGACCAGGGTGCACCGTGTCGGCCAGGCTGATCTTGAACTCCTGTGCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAGCCACCGCGCCCGGCCTCAGTTCACTGATTTCAGGTTTTGGTGTTTTACATTTAGAGCTACCTTCGTATGCTGGCTCCAGTATTTTAACGTGATATATGCGTTGTGATTATGACCGTCTTCAGTGCGCACCCCTTGATTCCAGTTTATTTAGTGCATTTAGGGAATGAGCAGAAGCTGCGTATAATC...
pathogenic
321,464
The mutation in gene PCNT (pericentrin) at chromosome 21, position 46416329—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
CACGCCCAGCCTTAGATGGCACCTTTTGATGCACTGTCTGCACCTCGCCTCCTCCAGTCCAAGGCCCAGCGCAGCCTCCCTGGACACACAGCCACCCACCCTTCTCCTCCTTCTCCTCTGGGACACACATCTGTCCACCCTCCTCCTCCTCCTCCTCCTGGACACAGTCGCCCACCCTCCTCCTCCTGGACACACAGCCGCCCACTCTCCTCTTCCTCCTCCTTCTCGACACACAACCACCCACCCTGCTCCTCCTCCTCCTCCTCCTGGACATGCAGCCGCCCACCCTCCTCCTCCTGGACACGCAGCCGCCCACCCTG...
CACGCCCAGCCTTAGATGGCACCTTTTGATGCACTGTCTGCACCTCGCCTCCTCCAGTCCAAGGCCCAGCGCAGCCTCCCTGGACACACAGCCACCCACCCTTCTCCTCCTTCTCCTCTGGGACACACATCTGTCCACCCTCCTCCTCCTCCTCCTCCTGGACACAGTCGCCCACCCTCCTCCTCCTGGACACACAGCCGCCCACTCTCCTCTTCCTCCTCCTTCTCGACACACAACCACCCACCCTGCTCCTCCTCCTCCTCCTCCTGGACATGCAGCCGCCCACCCTCCTCCTCCTGGACACGCAGCCGCCCACCCTG...
pathogenic
321,502
Clinical significance of chromosome 21, position 46418198, gene PCNT (pericentrin): benign or pathogenic? Name the disease(s) if pathogenic.
benign
AACCGTTTGCTGTATTCCATGACCTTCCAGAATGTGGATGCTGCCGACACCAAATCTCTGTGGCCCATGGCCTCAGCACACCTGTTGGAGAGCAGCTGGAGTGATGATTCCTGTGACGGAGAAGAGCCTGACATATCACCCCACATAGACACATGTGATGCCAATACAGCCACGGGGGGTGTAACTGATGTTATCAAAAATCAGGCCATAGACGCGTGTGATGCCAATACAACCCCAGGGGGTGTAACTGATGTTATCAAAAATTGGGATTCCTTGATACCAGATGAAATGCCAGATTCTCCCATTCAAGAAAAATCAGA...
AACCGTTTGCTGTATTCCATGACCTTCCAGAATGTGGATGCTGCCGACACCAAATCTCTGTGGCCCATGGCCTCAGCACACCTGTTGGAGAGCAGCTGGAGTGATGATTCCTGTGACGGAGAAGAGCCTGACATATCACCCCACATAGACACATGTGATGCCAATACAGCCACGGGGGGTGTAACTGATGTTATCAAAAATCAGGCCATAGACGCGTGTGATGCCAATACAACCCCAGGGGGTGTAACTGATGTTATCAAAAATTGGGATTCCTTGATACCAGATGAAATGCCAGATTCTCCCATTCAAGAAAAATCAGA...
benign
321,519
Is the variant located on chromosome 21 at position 46427743, gene PCNT (pericentrin), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
CCGAGGCGGTGCCCTCCCTCTCCACAGCTGCCCGCCCTTCACAGAGTCCTGGCGGCAGCTCGGGGCCGCAGGTGGTGTAGAGCGTGGCTGTGTGGGGTGGCAGGCAACTCCCTTCTGACGCGCTTTCCCGCCACAGGCTTTACTGCAGATGGTGCGTGACGAGAGCCACCAGATCCTGGCGCTGTCAGAAGGCCTTGCACCCCCAAGCGGCGAGCCACACCCACCCCGGAAGGAAGACGAGATACAGGACATCTCGCTCCATGGGGGAAAGACGCAGGTTTATTTTGCCCTTCACACACTTCTTTTCCAAAGGATTTAAG...
CCGAGGCGGTGCCCTCCCTCTCCACAGCTGCCCGCCCTTCACAGAGTCCTGGCGGCAGCTCGGGGCCGCAGGTGGTGTAGAGCGTGGCTGTGTGGGGTGGCAGGCAACTCCCTTCTGACGCGCTTTCCCGCCACAGGCTTTACTGCAGATGGTGCGTGACGAGAGCCACCAGATCCTGGCGCTGTCAGAAGGCCTTGCACCCCCAAGCGGCGAGCCACACCCACCCCGGAAGGAAGACGAGATACAGGACATCTCGCTCCATGGGGGAAAGACGCAGGTTTATTTTGCCCTTCACACACTTCTTTTCCAAAGGATTTAAG...
pathogenic
321,544
Chromosome 21, position 46430158, gene PCNT (pericentrin): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic
CTGGGTGGCGTTGGTGCCGTGGGGACACTGGAAATCCTGTTCCTGCCAGCATACACGAGGAAACCTAGTGTTGAGAGTAACTGGCTTGCAGGCCTCACGCAGGGTAGTGCAGCCCAGCCCTGACGCCTGCAGGCCCCAGAGCTGAGGCCCAGCAGATACTGTGCACCCATCCCAGACTCAGCAGGCTTGTCCCGGCGGAGCTGGTTTTGAGGGCGGGCAGCAGGGAAGGCCGGGGCATGGGGTGGCTGCCCAATGCTCAGGCTGCTTGTCCCATTGTGCCCCCAGGGAGACCTGCAGGAAAAGTCCCTGGAGCATCTTCG...
CTGGGTGGCGTTGGTGCCGTGGGGACACTGGAAATCCTGTTCCTGCCAGCATACACGAGGAAACCTAGTGTTGAGAGTAACTGGCTTGCAGGCCTCACGCAGGGTAGTGCAGCCCAGCCCTGACGCCTGCAGGCCCCAGAGCTGAGGCCCAGCAGATACTGTGCACCCATCCCAGACTCAGCAGGCTTGTCCCGGCGGAGCTGGTTTTGAGGGCGGGCAGCAGGGAAGGCCGGGGCATGGGGTGGCTGCCCAATGCTCAGGCTGCTTGTCCCATTGTGCCCCCAGGGAGACCTGCAGGAAAAGTCCCTGGAGCATCTTCG...
pathogenic
321,559
Does the chromosome 21 mutation at position 46432047 within gene PCNT (pericentrin) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['PCNT-related_disorder']
GTCTTTCTCAGTTGAACTGCTGGCTTATAAAGTAGAGCAGGAGAAGTGCATTGCTGGTGACTTGCAGAAGACGCTGAGTGAAGAGCAAGAGAAGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTC...
GTCTTTCTCAGTTGAACTGCTGGCTTATAAAGTAGAGCAGGAGAAGTGCATTGCTGGTGACTTGCAGAAGACGCTGAGTGAAGAGCAAGAGAAGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTC...
pathogenic
321,581
The genetic variant at chromosome 21, position 46432138, affecting gene PCNT (pericentrin): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
AAGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTCTGGTGGGCCGCAGTTGGGCAGCCCCAGGGGCACCGCGCCCTGCTGTCCCTGGGTTGATAATCCTGTGGTGGGGGGTGAAGCACACGTGTGG...
AAGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTCTGGTGGGCCGCAGTTGGGCAGCCCCAGGGGCACCGCGCCCTGCTGTCCCTGGGTTGATAATCCTGTGGTGGGGGGTGAAGCACACGTGTGG...
pathogenic
321,584
The mutation impacting PCNT (pericentrin) on chromosome 21 at position 46432237: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
TCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTCTGGTGGGCCGCAGTTGGGCAGCCCCAGGGGCACCGCGCCCTGCTGTCCCTGGGTTGATAATCCTGTGGTGGGGGGTGAAGCACACGTGTGGGACCTGGCAGGGCTCTGCCTCCCCTCCTGGAGCTCCCAGCCCCCGGGAACACACTCTGGCCCACGTGGTCAGATTGTTCTGCGATGTCTCCACGCAGAT...
TCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGGTGCGCCTGATCCCCCTTCCTGGGACACTGGCGGGAGTCCCCCCGTTGTGCCATGTTTTCTTGGTGATGAAGGGAGACAGAACCTCTGGTGGGCCGCAGTTGGGCAGCCCCAGGGGCACCGCGCCCTGCTGTCCCTGGGTTGATAATCCTGTGGTGGGGGGTGAAGCACACGTGTGGGACCTGGCAGGGCTCTGCCTCCCCTCCTGGAGCTCCCAGCCCCCGGGAACACACTCTGGCCCACGTGGTCAGATTGTTCTGCGATGTCTCCACGCAGAT...
benign
321,586
Mutation found at chromosome 21 position 46436019, gene PCNT (pericentrin): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II', 'PCNT-related_disorder']
TTTACCACATTGGTCAGGCTGGTCTTGAACTCCTGACCTTGTGATTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCCAGAGTGTTTTTTACTGAGGATAGTGAATTTGATCTGGATTATAGAACCCTTCTCTAGCTGTAGCCATGGAAGCCTCCCAAGATAGTGGCATGCTGGATACAATTCCATCTTTTCTAAATAATACAATCTCATTAGTTCCTCTGTATCTTACTTTCCTTACTAGAAAATAGAAAAGATACTCATTCCTGTTTAAGAGGCCCGAGCATTGAG...
TTTACCACATTGGTCAGGCTGGTCTTGAACTCCTGACCTTGTGATTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGATTACAGGCGTGAGCCACTGTGCCCGGCCTCCAGAGTGTTTTTTACTGAGGATAGTGAATTTGATCTGGATTATAGAACCCTTCTCTAGCTGTAGCCATGGAAGCCTCCCAAGATAGTGGCATGCTGGATACAATTCCATCTTTTCTAAATAATACAATCTCATTAGTTCCTCTGTATCTTACTTTCCTTACTAGAAAATAGAAAAGATACTCATTCCTGTTTAAGAGGCCCGAGCATTGAG...
pathogenic
321,591
Considering the variant on chromosome 21, location 46440991, involving gene PCNT (pericentrin), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
ACAGACATGAGCCACCGTGCCCGGCCTAAAGTGACTTATAATTTTCATAATGGTATAGTTGGATAGAGTTATCTTCCGGAATGTCTCATTTTTTTTTCTTTTGTATTTAGGCTATTTTGTTTGTGATTTGCTTTATTTTTTATAACTTTTTAAAAATTATTTTTAAATTTACATACAGTAAAATTTGCCCTTTCCTGGTGTAGTGTCATACAAGTTCACACACACACACATCCCTGTAACCTTCATAAGTAACCACCATTCACAGAGCACACAGCGATGGCCCCCCCAAAAAGAGCAGCAGGCATCTCCGCCTGCCACAG...
ACAGACATGAGCCACCGTGCCCGGCCTAAAGTGACTTATAATTTTCATAATGGTATAGTTGGATAGAGTTATCTTCCGGAATGTCTCATTTTTTTTTCTTTTGTATTTAGGCTATTTTGTTTGTGATTTGCTTTATTTTTTATAACTTTTTAAAAATTATTTTTAAATTTACATACAGTAAAATTTGCCCTTTCCTGGTGTAGTGTCATACAAGTTCACACACACACACATCCCTGTAACCTTCATAAGTAACCACCATTCACAGAGCACACAGCGATGGCCCCCCCAAAAAGAGCAGCAGGCATCTCCGCCTGCCACAG...
pathogenic
321,614
Is the genetic change at chromosome 21, position 46443854, within gene PCNT (pericentrin) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II']
AAGGCAGTGGTGTCCCAGAAAGGAGCAGTCTCTGTGTCCCTGTGAGGGCACTGCCTAGGGTAGCTGCCACCAAGGGGCCTTGACAGGTCTTATGGAGGAATCGGCAGTGTCTGCTATGCCTCAAAGGAGGGAAGCCACAGGCATGATGCTTGTTCCGAAGGCCATCCTAGCAGGGCGTCTGGGGCCCTGCACACTGACCTGCATGCCCTCGTCACCTGCACTCTGCATGCTCACCATCTGACGGACTCCTGCGAGGGCTGGGGTCTCCGTGTTCTGAGCCTGTCCAGTGGCATCTGTGACAGGATGAAGATGGGAGGGTC...
AAGGCAGTGGTGTCCCAGAAAGGAGCAGTCTCTGTGTCCCTGTGAGGGCACTGCCTAGGGTAGCTGCCACCAAGGGGCCTTGACAGGTCTTATGGAGGAATCGGCAGTGTCTGCTATGCCTCAAAGGAGGGAAGCCACAGGCATGATGCTTGTTCCGAAGGCCATCCTAGCAGGGCGTCTGGGGCCCTGCACACTGACCTGCATGCCCTCGTCACCTGCACTCTGCATGCTCACCATCTGACGGACTCCTGCGAGGGCTGGGGTCTCCGTGTTCTGAGCCTGTCCAGTGGCATCTGTGACAGGATGAAGATGGGAGGGTC...
pathogenic
321,627
Gene PCNT (pericentrin) variant at chromosome position 46444720 on chromosome 21: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Microcephalic_osteodysplastic_primordial_dwarfism_type_II', 'PCNT-related_disorder']
GTAATAAAGCACGGTAAGAAAATCCGTGAATTCCGTCAGAGCAGTCGTCCAGAGGGAAGGCGCGCCCGGCGTAGGGAGGTCAGAGCTCATGTTAGCTATGAACACAGGTCACAGGGGCGTACGGCGATGGGAAACACTGAGATGCTCAATATATTGATTATTTAATAGTGTTTAGCAAAATGGTCTTTTTTTATTCCTTAAATCAACTGAAACTCACTTCACGTCTCTTTCCTTGTAGAGCATCATGCTTATTTCTGGCTCACTCACATCTTTGTCTCGGGAGTTCTCTGCCGAGCCATTGCCCCCTACAGCAGAGAGCA...
GTAATAAAGCACGGTAAGAAAATCCGTGAATTCCGTCAGAGCAGTCGTCCAGAGGGAAGGCGCGCCCGGCGTAGGGAGGTCAGAGCTCATGTTAGCTATGAACACAGGTCACAGGGGCGTACGGCGATGGGAAACACTGAGATGCTCAATATATTGATTATTTAATAGTGTTTAGCAAAATGGTCTTTTTTTATTCCTTAAATCAACTGAAACTCACTTCACGTCTCTTTCCTTGTAGAGCATCATGCTTATTTCTGGCTCACTCACATCTTTGTCTCGGGAGTTCTCTGCCGAGCCATTGCCCCCTACAGCAGAGAGCA...
pathogenic
321,630
Evaluate this variant at chromosome 22, position 17181858, gene ADA2 (adenosine deaminase 2): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autoinflammatory_syndrome', 'Sneddon_syndrome', 'Vasculitis_due_to_ADA2_deficiency']
GAGTGACCTGATTTAATTTGATCTTTTAAAAGTCATTCTAGGCCAGGCCGGGTGGCTCACGCCTGTAATCCCAGTGCTTTGGGAGGCCGAGGCGGGTGGACCACGAGGTCAGGTGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCACCGCTGCACTCCACCCTGGGCAACAGAGCGAGACTCCATCT...
GAGTGACCTGATTTAATTTGATCTTTTAAAAGTCATTCTAGGCCAGGCCGGGTGGCTCACGCCTGTAATCCCAGTGCTTTGGGAGGCCGAGGCGGGTGGACCACGAGGTCAGGTGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCACCGCTGCACTCCACCCTGGGCAACAGAGCGAGACTCCATCT...
pathogenic
321,710
The genetic variant at chromosome 22, position 17182776, affecting gene ADA2 (adenosine deaminase 2): benign or pathogenic? Disease name(s) if pathogenic?
benign
TAAATAAATGTGGGAATCATTAACAAATAAATGGTATGAAAAAGCAAAGGAATGGATGAGACCACCCAGGAAAAGTGTACAGAGAGAGAAGAGAAATAAAGAGGAGAGAGTTAAAGAGACCAGAATAGGCCAGGCATGGTGGCTAATGCCTGTAATTCCAGCACTTTGGGAGCCAAGGGGCGAGTGGATCACCTGAGGTCAAGAGTTGGATACCAGCCTCGCCAACATGGTGAAAACCTGTCTCTACTAAAAATGCAAAAATCAGCTGGGTGTGGTGGCACATGCCTATAATTCCAACTACTCGCGAGGCTGATGCAAGA...
TAAATAAATGTGGGAATCATTAACAAATAAATGGTATGAAAAAGCAAAGGAATGGATGAGACCACCCAGGAAAAGTGTACAGAGAGAGAAGAGAAATAAAGAGGAGAGAGTTAAAGAGACCAGAATAGGCCAGGCATGGTGGCTAATGCCTGTAATTCCAGCACTTTGGGAGCCAAGGGGCGAGTGGATCACCTGAGGTCAAGAGTTGGATACCAGCCTCGCCAACATGGTGAAAACCTGTCTCTACTAAAAATGCAAAAATCAGCTGGGTGTGGTGGCACATGCCTATAATTCCAACTACTCGCGAGGCTGATGCAAGA...
benign
321,720
Is the genetic change at chromosome 22, position 17189972, within gene ADA2 (adenosine deaminase 2) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Sneddon_syndrome', 'Vasculitis_due_to_ADA2_deficiency']
GAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGTGCCTGTAGTACCAGCTACTTGGAAGGCTGAGGCAGGAGACTCTCTTGAACCTGGGAAGCCGAGGTTGCAGTGAGCTGGGCGACAGAGGGAGACTCCGTAAAAAAAAGAAAAAAAAAGAAGAAGAAGAAAAGAAAACAGGAAGGAAAGAAGAAAGAGAAACTAGAAATAATACATGTAAAGTGGCTGATTCTATTATCCTTGTTATTCCTTCTCCATGGGGCTGTTGTCAGGATTAAGTGAGATAGAGCACAGGAAAGGGCTCTGGAA...
GAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGTGCCTGTAGTACCAGCTACTTGGAAGGCTGAGGCAGGAGACTCTCTTGAACCTGGGAAGCCGAGGTTGCAGTGAGCTGGGCGACAGAGGGAGACTCCGTAAAAAAAAGAAAAAAAAAGAAGAAGAAGAAAAGAAAACAGGAAGGAAAGAAGAAAGAGAAACTAGAAATAATACATGTAAAGTGGCTGATTCTATTATCCTTGTTATTCCTTCTCCATGGGGCTGTTGTCAGGATTAAGTGAGATAGAGCACAGGAAAGGGCTCTGGAA...
pathogenic
321,739
Is the chromosome 22, position 17190042 variant in ADA2 (adenosine deaminase 2) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
CTTGGAAGGCTGAGGCAGGAGACTCTCTTGAACCTGGGAAGCCGAGGTTGCAGTGAGCTGGGCGACAGAGGGAGACTCCGTAAAAAAAAGAAAAAAAAAGAAGAAGAAGAAAAGAAAACAGGAAGGAAAGAAGAAAGAGAAACTAGAAATAATACATGTAAAGTGGCTGATTCTATTATCCTTGTTATTCCTTCTCCATGGGGCTGTTGTCAGGATTAAGTGAGATAGAGCACAGGAAAGGGCTCTGGAAACGCCTGTAGGCTCTAACCCTGAGGCATGGGCCTGTGGCCAGGAGCTCTCCCATTGACCACCTCCGCTGC...
CTTGGAAGGCTGAGGCAGGAGACTCTCTTGAACCTGGGAAGCCGAGGTTGCAGTGAGCTGGGCGACAGAGGGAGACTCCGTAAAAAAAAGAAAAAAAAAGAAGAAGAAGAAAAGAAAACAGGAAGGAAAGAAGAAAGAGAAACTAGAAATAATACATGTAAAGTGGCTGATTCTATTATCCTTGTTATTCCTTCTCCATGGGGCTGTTGTCAGGATTAAGTGAGATAGAGCACAGGAAAGGGCTCTGGAAACGCCTGTAGGCTCTAACCCTGAGGCATGGGCCTGTGGCCAGGAGCTCTCCCATTGACCACCTCCGCTGC...
benign
321,742
Determine if the mutation at chromosome 22, position 17191821 in gene ADA2 (adenosine deaminase 2) is benign or pathogenic. If pathogenic, what disease(s) is associated?
benign
CGCTGAGCTCTGAGCAGCCCTGCTGTGTCAGCAGCCTGAGCCTGCCCTGGGATGTCAGGGTACCAACAGGCACATTGCGCTCCCTTCCCAGGGAGTTGCCGCTCCACCCAGACAGGCATCCTCGCATGCCCCCTTAACAGGCAGCCCTTCTGTTCACAGCATGGGTTACCAGGTCAAACCCTGCCACCACCGTGGGGAACTTGATTCGGAGCCCCATGGCCATTCGGATGGATTCTGCGATGACAGCCACATCTTTGGATCTGTGAGACAGACAGAGAAGCCAGGAGACAGTGCCCAGCACCGACAGAGCACAAACCCCA...
CGCTGAGCTCTGAGCAGCCCTGCTGTGTCAGCAGCCTGAGCCTGCCCTGGGATGTCAGGGTACCAACAGGCACATTGCGCTCCCTTCCCAGGGAGTTGCCGCTCCACCCAGACAGGCATCCTCGCATGCCCCCTTAACAGGCAGCCCTTCTGTTCACAGCATGGGTTACCAGGTCAAACCCTGCCACCACCGTGGGGAACTTGATTCGGAGCCCCATGGCCATTCGGATGGATTCTGCGATGACAGCCACATCTTTGGATCTGTGAGACAGACAGAGAAGCCAGGAGACAGTGCCCAGCACCGACAGAGCACAAACCCCA...
benign
321,749
Variant on chromosome 22, at position 17199694, affecting ADA2 (adenosine deaminase 2): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
CAGGCATATGCAGGGGGCTTTATGCCATAATCTCATTTAACCCTCAAAACTACACTATGAGGTAGGTCTCATTTTACAGATAAGGATTTTGAGGCTTTAAAAGTTTGAGAAGGCTGAGCACGGTGGCTCACGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAGGTCACGAATTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATAGAAAATTAGCCGGGTGTGGTGGCACATGCCTGTATTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG...
CAGGCATATGCAGGGGGCTTTATGCCATAATCTCATTTAACCCTCAAAACTACACTATGAGGTAGGTCTCATTTTACAGATAAGGATTTTGAGGCTTTAAAAGTTTGAGAAGGCTGAGCACGGTGGCTCACGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAGGTCACGAATTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATAGAAAATTAGCCGGGTGTGGTGGCACATGCCTGTATTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG...
benign
321,752
Determine whether the variant at chromosome 22, position 17203651, in gene ADA2 (adenosine deaminase 2) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Sneddon_syndrome', 'Vasculitis_due_to_ADA2_deficiency']
GTCTGAGCTCACCACATAAAACACCCAAGGATCCTGCCCACTCCCACAATACCCCATCTCCCTCAGCCCAACAAAAACATCCTCAGGAAAGTTCTCTCCAATAAACTCACTGAAATAAAACTCTAGCAGTATTTGAGCACCTAGGGCTGCTCTCCTCGAAAGATCCCTCCCCTACCAACACGGAGCCTGGTGTCAGTCCATCTCAGAGTACCTAACCTCAGTTATCCTTTGCTTCTGGCCAAAATGCAAGACCCAAAAATCAGATTTTTTTGATGATGCTCCCTTCTTTTGGACTCTTTCTACTCCTTTCCATTTCACTC...
GTCTGAGCTCACCACATAAAACACCCAAGGATCCTGCCCACTCCCACAATACCCCATCTCCCTCAGCCCAACAAAAACATCCTCAGGAAAGTTCTCTCCAATAAACTCACTGAAATAAAACTCTAGCAGTATTTGAGCACCTAGGGCTGCTCTCCTCGAAAGATCCCTCCCCTACCAACACGGAGCCTGGTGTCAGTCCATCTCAGAGTACCTAACCTCAGTTATCCTTTGCTTCTGGCCAAAATGCAAGACCCAAAAATCAGATTTTTTTGATGATGCTCCCTTCTTTTGGACTCTTTCTACTCCTTTCCATTTCACTC...
pathogenic
321,759
A genetic alteration at chromosome 22, position 17209533, in gene ADA2 (adenosine deaminase 2)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Sneddon_syndrome', 'Splenomegaly', 'Vasculitis_due_to_ADA2_deficiency']
TGGGGACAGTGTGGATCACAAGAAGACGTGCAAGCAGAAGGATTTCTGTCCAGACATGTTTCTCGGAACTTGTTTAAGGCTCTAGTTTAAGGATGGGGCTTCCATGTCTCACTAATCAGGAGCCAGGGGTGATCTTGTCCAAGAGGGGCAGCATGGGAGAGTGAGAGGGCATCAGGCTTGGAACCAGAGAACTGAGGTTCAAGTCAGGGCTCCATTGGCTTCTAGCTCTCCAATGGGAGCCCAGGCCTTTCAATGAGGCCACCCAACACTGCATGACGGGATACACTGGGATGAGCCCCAGGGCCACGGTCCTTTTCACA...
TGGGGACAGTGTGGATCACAAGAAGACGTGCAAGCAGAAGGATTTCTGTCCAGACATGTTTCTCGGAACTTGTTTAAGGCTCTAGTTTAAGGATGGGGCTTCCATGTCTCACTAATCAGGAGCCAGGGGTGATCTTGTCCAAGAGGGGCAGCATGGGAGAGTGAGAGGGCATCAGGCTTGGAACCAGAGAACTGAGGTTCAAGTCAGGGCTCCATTGGCTTCTAGCTCTCCAATGGGAGCCCAGGCCTTTCAATGAGGCCACCCAACACTGCATGACGGGATACACTGGGATGAGCCCCAGGGCCACGGTCCTTTTCACA...
pathogenic
321,771
Does the genetic variant at chromosome 22, position 17209533, impacting gene ADA2 (adenosine deaminase 2), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Sneddon_syndrome', 'Vasculitis_due_to_ADA2_deficiency']
TGGGGACAGTGTGGATCACAAGAAGACGTGCAAGCAGAAGGATTTCTGTCCAGACATGTTTCTCGGAACTTGTTTAAGGCTCTAGTTTAAGGATGGGGCTTCCATGTCTCACTAATCAGGAGCCAGGGGTGATCTTGTCCAAGAGGGGCAGCATGGGAGAGTGAGAGGGCATCAGGCTTGGAACCAGAGAACTGAGGTTCAAGTCAGGGCTCCATTGGCTTCTAGCTCTCCAATGGGAGCCCAGGCCTTTCAATGAGGCCACCCAACACTGCATGACGGGATACACTGGGATGAGCCCCAGGGCCACGGTCCTTTTCACA...
TGGGGACAGTGTGGATCACAAGAAGACGTGCAAGCAGAAGGATTTCTGTCCAGACATGTTTCTCGGAACTTGTTTAAGGCTCTAGTTTAAGGATGGGGCTTCCATGTCTCACTAATCAGGAGCCAGGGGTGATCTTGTCCAAGAGGGGCAGCATGGGAGAGTGAGAGGGCATCAGGCTTGGAACCAGAGAACTGAGGTTCAAGTCAGGGCTCCATTGGCTTCTAGCTCTCCAATGGGAGCCCAGGCCTTTCAATGAGGCCACCCAACACTGCATGACGGGATACACTGGGATGAGCCCCAGGGCCACGGTCCTTTTCACA...
pathogenic
321,772
Is chromosome 22, position 17594620, gene ATP6V1E1 (ATPase H+ transporting V1 subunit E1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
GGCAGTGAAGAGGAAGCTACAGAGACATTCGTGTTTCTTCAAATATCAGAAGCTTCCACATCACAGCAGGAGAGCTGACGACGAGCTCCACCTCCTGAAGGCTTAGTCCAAAAACTTCCTGTTGGCATTTGCACCAAACAAGGCTCCCCGGACTTCTGGCATCATCTGTGGAGAGAAAGTGTAATAAATACGCAATGTCAGCTGAAGAAGTTGTAGAGCGCTGCACATCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCATCTCCGCTCATTGCAAGCTCACGCC...
GGCAGTGAAGAGGAAGCTACAGAGACATTCGTGTTTCTTCAAATATCAGAAGCTTCCACATCACAGCAGGAGAGCTGACGACGAGCTCCACCTCCTGAAGGCTTAGTCCAAAAACTTCCTGTTGGCATTTGCACCAAACAAGGCTCCCCGGACTTCTGGCATCATCTGTGGAGAGAAAGTGTAATAAATACGCAATGTCAGCTGAAGAAGTTGTAGAGCGCTGCACATCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCATCTCCGCTCATTGCAAGCTCACGCC...
benign
321,801
Chromosome 22, position 17594620, gene ATP6V1E1 (ATPase H+ transporting V1 subunit E1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
GGCAGTGAAGAGGAAGCTACAGAGACATTCGTGTTTCTTCAAATATCAGAAGCTTCCACATCACAGCAGGAGAGCTGACGACGAGCTCCACCTCCTGAAGGCTTAGTCCAAAAACTTCCTGTTGGCATTTGCACCAAACAAGGCTCCCCGGACTTCTGGCATCATCTGTGGAGAGAAAGTGTAATAAATACGCAATGTCAGCTGAAGAAGTTGTAGAGCGCTGCACATCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCATCTCCGCTCATTGCAAGCTCACGCC...
GGCAGTGAAGAGGAAGCTACAGAGACATTCGTGTTTCTTCAAATATCAGAAGCTTCCACATCACAGCAGGAGAGCTGACGACGAGCTCCACCTCCTGAAGGCTTAGTCCAAAAACTTCCTGTTGGCATTTGCACCAAACAAGGCTCCCCGGACTTCTGGCATCATCTGTGGAGAGAAAGTGTAATAAATACGCAATGTCAGCTGAAGAAGTTGTAGAGCGCTGCACATCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCATCTCCGCTCATTGCAAGCTCACGCC...
benign
321,802
Determine if the mutation at chromosome 22, position 18078398 in gene PEX26 is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Peroxisome_biogenesis_disorder_7A_(Zellweger)', 'Peroxisome_biogenesis_disorder_7B']
CTTAATGCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTA...
CTTAATGCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTA...
pathogenic
321,854
For chromosome 22, position 18078404, gene PEX26 (peroxisomal biogenesis factor 26): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Peroxisome_biogenesis_disorder', 'Peroxisome_biogenesis_disorder_7A_(Zellweger)', 'Peroxisome_biogenesis_disorder_7B']
GCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAAT...
GCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAAT...
pathogenic
321,855
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 22, position 18078404, gene PEX26 (peroxisomal biogenesis factor 26). What disease(s) is it linked to if pathogenic?
pathogenic; ['Peroxisome_biogenesis_disorder_7A_(Zellweger)']
GCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAAT...
GCGCATGGCGCTTTATGCGCAATATTACTTAATTCTTCCCTCAGCCATTGGGAGCTAAGGACAAACTGTTATCCCAATTTTACAGGTGAGGAAATCAGAGCTTATTTAAATAAATTGCCGAGGTCACACAACTAGTAAGCGACAAAATCTCAGTCAAACCGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAAT...
pathogenic
321,856
Is the genetic variant on chromosome 22, position 18078563, gene PEX26 (peroxisomal biogenesis factor 26), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['PEX26-related_disorder', 'Peroxisome_biogenesis_disorder_7A_(Zellweger)', 'Peroxisome_biogenesis_disorder_7B']
CGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAATGCACTTTATAGTAAAGTACTGGGAACAGAGTATTTGGTAAATTGTAACTATAATAATAATTTTAAACAGATCCACAAATCACACTTATTATTATATTCTGTTTCACCCGGGCTTTGCCAAGCTTCCCACATTTGTACTAGATCCTCTTGGCTTTAGTTT...
CGAGGCTCTTTTGGTTCAAAGATGTGTATTGAGCTCTACTCTGCTCTGCAGGGACAGAACTAAGTATGTTTGCTATTCAGGGGATACACAGTCATTCCATGAGCAAGTTACACAATGTAAAATAAGGACATTGTGAAAAACAAAACCATACCGTACATAATGCACTTTATAGTAAAGTACTGGGAACAGAGTATTTGGTAAATTGTAACTATAATAATAATTTTAAACAGATCCACAAATCACACTTATTATTATATTCTGTTTCACCCGGGCTTTGCCAAGCTTCCCACATTTGTACTAGATCCTCTTGGCTTTAGTTT...
pathogenic
321,859
For chromosome 22, position 18079896, gene PEX26 (peroxisomal biogenesis factor 26): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Peroxisome_biogenesis_disorder_7A_(Zellweger)', 'Peroxisome_biogenesis_disorder_7B']
CTCACGGCACAGGGGCGGCTTCCGGGGCGCGGCGTGCTGGGGGTTGTAGTCCGCGCTCTGCCTCCTACTTCCATTACAGAAGGCGATGGGCCGAGAGCTGAGGAACTACAACTCCTAGAGTACTCCGCGCCGCCGGGACGCCGCGCGGCTGCGGGGCTGGGCGAGCGCAAAGATGTCCGCGCCCGCTGCCGGGAGGCGAGGTGAGTCTTTGATCGTAACCAGGAGCCCGGAGCTGAGGCAGTTCCTGCACGTGTCGCGGGGCCGGAGAAGCTAGGGCCAGGTATTCCAGGGATGCAAGAATCCTGCAAATCTGACGTGTA...
CTCACGGCACAGGGGCGGCTTCCGGGGCGCGGCGTGCTGGGGGTTGTAGTCCGCGCTCTGCCTCCTACTTCCATTACAGAAGGCGATGGGCCGAGAGCTGAGGAACTACAACTCCTAGAGTACTCCGCGCCGCCGGGACGCCGCGCGGCTGCGGGGCTGGGCGAGCGCAAAGATGTCCGCGCCCGCTGCCGGGAGGCGAGGTGAGTCTTTGATCGTAACCAGGAGCCCGGAGCTGAGGCAGTTCCTGCACGTGTCGCGGGGCCGGAGAAGCTAGGGCCAGGTATTCCAGGGATGCAAGAATCCTGCAAATCTGACGTGTA...
pathogenic
321,863
Is the genetic variant on chromosome 22, position 18079971, gene PEX26 (peroxisomal biogenesis factor 26), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Peroxisome_biogenesis_disorder_7A_(Zellweger)', 'Peroxisome_biogenesis_disorder_7B']
ACAGAAGGCGATGGGCCGAGAGCTGAGGAACTACAACTCCTAGAGTACTCCGCGCCGCCGGGACGCCGCGCGGCTGCGGGGCTGGGCGAGCGCAAAGATGTCCGCGCCCGCTGCCGGGAGGCGAGGTGAGTCTTTGATCGTAACCAGGAGCCCGGAGCTGAGGCAGTTCCTGCACGTGTCGCGGGGCCGGAGAAGCTAGGGCCAGGTATTCCAGGGATGCAAGAATCCTGCAAATCTGACGTGTAAACTGCTTCCCCAGCCTCCAGGCGAGCCCAGCTTTTGCCTCAGATAGGCCCCTTCCTTTTCCTTCTCGGGGAATC...
ACAGAAGGCGATGGGCCGAGAGCTGAGGAACTACAACTCCTAGAGTACTCCGCGCCGCCGGGACGCCGCGCGGCTGCGGGGCTGGGCGAGCGCAAAGATGTCCGCGCCCGCTGCCGGGAGGCGAGGTGAGTCTTTGATCGTAACCAGGAGCCCGGAGCTGAGGCAGTTCCTGCACGTGTCGCGGGGCCGGAGAAGCTAGGGCCAGGTATTCCAGGGATGCAAGAATCCTGCAAATCTGACGTGTAAACTGCTTCCCCAGCCTCCAGGCGAGCCCAGCTTTTGCCTCAGATAGGCCCCTTCCTTTTCCTTCTCGGGGAATC...
pathogenic
321,866