question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Is chromosome 22, position 41515902, gene ACO2 (aconitase 2) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic
CTGTCACGGCCAGCGTCATCGTGACATCTTCTGCAGTCCTCATGTCTGCCTGACCTCTCCCCCTGGATGTGGACCACAAGTGTCTACACCGTGTGGACCACAAGTGTCTACACCGTGTAGACCACCCCGAATTCTGTGTGCCCAGCCTTCGTGGATCCAACTTTTACAAGCTTGAGGCTCTTTAGGGATGCACTAGTCTTAAATCCTTGTACGTGGCAGCATTGGCCAGTTCTTCGCAGCCAGGTCTTCCCTCTGCATCCCCAAGAGATGAGACCTTTGGACCTTAGAGTCTGCTAGGCAGATGCTTGTCCTGAGGCAGA...
CTGTCACGGCCAGCGTCATCGTGACATCTTCTGCAGTCCTCATGTCTGCCTGACCTCTCCCCCTGGATGTGGACCACAAGTGTCTACACCGTGTGGACCACAAGTGTCTACACCGTGTAGACCACCCCGAATTCTGTGTGCCCAGCCTTCGTGGATCCAACTTTTACAAGCTTGAGGCTCTTTAGGGATGCACTAGTCTTAAATCCTTGTACGTGGCAGCATTGGCCAGTTCTTCGCAGCCAGGTCTTCCCTCTGCATCCCCAAGAGATGAGACCTTTGGACCTTAGAGTCTGCTAGGCAGATGCTTGTCCTGAGGCAGA...
pathogenic
327,656
Evaluate if the mutation on chromosome 22 at position 41527918 in ACO2 is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Inborn_genetic_diseases']
GCACCCCTGTGACAGAAGAGACTAATCAGTCATCAGCCAGGACCCAGGCATGTCCTGGGCTCCTGTGTCCAGCATGAGGTCTGTGGCTGATCTTGCAGCTGAGGCCTGAAGGGTGAGCGAACATTGACCTGTCCCAACTTTGGGCGGCCTCTGCCCCATAAGGGAGACTGAGCAGCCAGAGGCCTTTGAGGGGATGAAGGCCTGGCCTGAGCCCATGTGGCCTTAGGGTGGAAGCACCAGGACCACAGAACACGTGTCTGAAGACTTGCCTGCCTCTCACCCCTCTGTCACCCCTCCTGGGCCCCGGGGCCTGCTGCCTG...
GCACCCCTGTGACAGAAGAGACTAATCAGTCATCAGCCAGGACCCAGGCATGTCCTGGGCTCCTGTGTCCAGCATGAGGTCTGTGGCTGATCTTGCAGCTGAGGCCTGAAGGGTGAGCGAACATTGACCTGTCCCAACTTTGGGCGGCCTCTGCCCCATAAGGGAGACTGAGCAGCCAGAGGCCTTTGAGGGGATGAAGGCCTGGCCTGAGCCCATGTGGCCTTAGGGTGGAAGCACCAGGACCACAGAACACGTGTCTGAAGACTTGCCTGCCTCTCACCCCTCTGTCACCCCTCCTGGGCCCCGGGGCCTGCTGCCTG...
pathogenic
327,699
Regarding the variant found on chromosome 22 at position 42128173 in gene CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)): is it benign or pathogenic? If pathogenic, identify the disease(s).
benign
GAGGTGACTGTTGTGATGGTGCTGGCAGGACTGCTGTCCCTGATGTGGGGTGGGCTGAGTTAGGCCTGAAATATGGGCCTCCAGGCTGAGTCCTGCCCTCTCCACCACATCCAGGGCTGACTGACACCTCTAGTCAGCCCATTCTGGCCCCTTCCCCACATGCCAGGACAATGTAGTCCTTGTCACCAATCTGGGCAGTCAGAGTTGGGTCAGTGGGGGACATGGGATTATGGGCAAGGGTAACTGACATCTGCTCAGCCTCAACGTACCCCTGTCTCAAATGCGGCCAGGCGGTGGGGTAAGCAGGAATGAGGCAGGGG...
GAGGTGACTGTTGTGATGGTGCTGGCAGGACTGCTGTCCCTGATGTGGGGTGGGCTGAGTTAGGCCTGAAATATGGGCCTCCAGGCTGAGTCCTGCCCTCTCCACCACATCCAGGGCTGACTGACACCTCTAGTCAGCCCATTCTGGCCCCTTCCCCACATGCCAGGACAATGTAGTCCTTGTCACCAATCTGGGCAGTCAGAGTTGGGTCAGTGGGGGACATGGGATTATGGGCAAGGGTAACTGACATCTGCTCAGCCTCAACGTACCCCTGTCTCAAATGCGGCCAGGCGGTGGGGTAAGCAGGAATGAGGCAGGGG...
benign
327,790
The genetic variant at chromosome 22, position 42128241, affecting gene CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)): benign or pathogenic? Disease name(s) if pathogenic?
benign
AAATATGGGCCTCCAGGCTGAGTCCTGCCCTCTCCACCACATCCAGGGCTGACTGACACCTCTAGTCAGCCCATTCTGGCCCCTTCCCCACATGCCAGGACAATGTAGTCCTTGTCACCAATCTGGGCAGTCAGAGTTGGGTCAGTGGGGGACATGGGATTATGGGCAAGGGTAACTGACATCTGCTCAGCCTCAACGTACCCCTGTCTCAAATGCGGCCAGGCGGTGGGGTAAGCAGGAATGAGGCAGGGGTGGGGTTGCCCTGAGGAGGATGATCCCAACGAGGGCGTGAGCAGGGGACCCGAGTTGGAACTACCACA...
AAATATGGGCCTCCAGGCTGAGTCCTGCCCTCTCCACCACATCCAGGGCTGACTGACACCTCTAGTCAGCCCATTCTGGCCCCTTCCCCACATGCCAGGACAATGTAGTCCTTGTCACCAATCTGGGCAGTCAGAGTTGGGTCAGTGGGGGACATGGGATTATGGGCAAGGGTAACTGACATCTGCTCAGCCTCAACGTACCCCTGTCTCAAATGCGGCCAGGCGGTGGGGTAAGCAGGAATGAGGCAGGGGTGGGGTTGCCCTGAGGAGGATGATCCCAACGAGGGCGTGAGCAGGGGACCCGAGTTGGAACTACCACA...
benign
327,791
A genetic alteration at chromosome 22, position 42129083, in gene CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene))—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
GATGCTGGGACCCCTGCCACCAAACACACGGGGGACACACACTGCCTGGCACACAGCTGGACTCTGTCAACTAGTCCTGCGCCCGAGAAGCTCCACAGTACCCTCTCCGACCCCACAGCAGGGCGCAGTCACACCTCTCAGAGGCACCCACACTGCCCCCTCTCCCTGCAGGCGTTGGGTCCTCCAACATTCTGGCAGGTCCTGGTTTGTCTCCCCACTAGACGGGGGCTCTGGATGGACAGGCCAGCCCTGCCTATACTCTGGACCCCCCACCCAAGTGGGGACAGTCAGTGTGGTGGCATTGAGGACTAGGTGGCCAG...
GATGCTGGGACCCCTGCCACCAAACACACGGGGGACACACACTGCCTGGCACACAGCTGGACTCTGTCAACTAGTCCTGCGCCCGAGAAGCTCCACAGTACCCTCTCCGACCCCACAGCAGGGCGCAGTCACACCTCTCAGAGGCACCCACACTGCCCCCTCTCCCTGCAGGCGTTGGGTCCTCCAACATTCTGGCAGGTCCTGGTTTGTCTCCCCACTAGACGGGGGCTCTGGATGGACAGGCCAGCCCTGCCTATACTCTGGACCCCCCACCCAAGTGGGGACAGTCAGTGTGGTGGCATTGAGGACTAGGTGGCCAG...
benign
327,797
Evaluate this variant at chromosome 22, position 42210563, gene TCF20 (transcription factor 20): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Developmental_delay_with_variable_intellectual_impairment_and_behavioral_abnormalities', 'Neurodevelopmental_abnormality']
TACCAGGGAGCCCCAGAGTTCGAGAATGCAGTAAGCTGTGATCGCACCACTGCATTCCAGCCTGAGTGACAACAAAACAAAACAAAACAAAACAAAACCAAAACAAAACCCACATACAAAAAAGATTAGATGATAAAGCTGAAGAAAGCATAGAGAAATCAGAACAAAAAGATAATGAGATAAAACATAAAACAGAGGAGAAAAGATAAAAACAGCGGATCAATCCAGGAGGTAAAATGCCTTATATTAACAGGAATTATAAAGAGAGCAGAGAAAATAGAGGGAAGGAAATTTTCAAAGAACTACCACATGACAAATTG...
TACCAGGGAGCCCCAGAGTTCGAGAATGCAGTAAGCTGTGATCGCACCACTGCATTCCAGCCTGAGTGACAACAAAACAAAACAAAACAAAACAAAACCAAAACAAAACCCACATACAAAAAAGATTAGATGATAAAGCTGAAGAAAGCATAGAGAAATCAGAACAAAAAGATAATGAGATAAAACATAAAACAGAGGAGAAAAGATAAAAACAGCGGATCAATCCAGGAGGTAAAATGCCTTATATTAACAGGAATTATAAAGAGAGCAGAGAAAATAGAGGGAAGGAAATTTTCAAAGAACTACCACATGACAAATTG...
pathogenic
327,817
Regarding the variant found on chromosome 22 at position 42210568 in gene TCF20 (transcription factor 20): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Developmental_delay_with_variable_intellectual_impairment_and_behavioral_abnormalities']
GGGAGCCCCAGAGTTCGAGAATGCAGTAAGCTGTGATCGCACCACTGCATTCCAGCCTGAGTGACAACAAAACAAAACAAAACAAAACAAAACCAAAACAAAACCCACATACAAAAAAGATTAGATGATAAAGCTGAAGAAAGCATAGAGAAATCAGAACAAAAAGATAATGAGATAAAACATAAAACAGAGGAGAAAAGATAAAAACAGCGGATCAATCCAGGAGGTAAAATGCCTTATATTAACAGGAATTATAAAGAGAGCAGAGAAAATAGAGGGAAGGAAATTTTCAAAGAACTACCACATGACAAATTGCCTGA...
GGGAGCCCCAGAGTTCGAGAATGCAGTAAGCTGTGATCGCACCACTGCATTCCAGCCTGAGTGACAACAAAACAAAACAAAACAAAACAAAACCAAAACAAAACCCACATACAAAAAAGATTAGATGATAAAGCTGAAGAAAGCATAGAGAAATCAGAACAAAAAGATAATGAGATAAAACATAAAACAGAGGAGAAAAGATAAAAACAGCGGATCAATCCAGGAGGTAAAATGCCTTATATTAACAGGAATTATAAAGAGAGCAGAGAAAATAGAGGGAAGGAAATTTTCAAAGAACTACCACATGACAAATTGCCTGA...
pathogenic
327,818
The mutation impacting TCF20 (transcription factor 20) on chromosome 22 at position 42211501: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Intellectual_disability', 'TCF20-related_disorder']
ACATTTCAAAAAATGAAAAACGATTTTAGAAGTCTATACAAATCTTCCAAATTACCTATTTCATTTTCTGTCCATCACATGGGCATAGGCACTTTAATTTGGAGGAATAATCATGTGACATGTAAGAACAAAAACATGCAAGAAAAGGAACCAAATGAAATAAAAATCCCAAGCTGGTAAGAGATTTCTCATACTCACCATCTCTCTGGCTATTTCCAGCGCTTCCTGCAGGCCATAGAGCCTGCCACAAACCAGGTAGATTCCATTGGCCCAGAGAATACAACCCTCATGGACCCAAAATTCATTGCTGTCAAGAGGTA...
ACATTTCAAAAAATGAAAAACGATTTTAGAAGTCTATACAAATCTTCCAAATTACCTATTTCATTTTCTGTCCATCACATGGGCATAGGCACTTTAATTTGGAGGAATAATCATGTGACATGTAAGAACAAAAACATGCAAGAAAAGGAACCAAATGAAATAAAAATCCCAAGCTGGTAAGAGATTTCTCATACTCACCATCTCTCTGGCTATTTCCAGCGCTTCCTGCAGGCCATAGAGCCTGCCACAAACCAGGTAGATTCCATTGGCCCAGAGAATACAACCCTCATGGACCCAAAATTCATTGCTGTCAAGAGGTA...
pathogenic
327,830
Regarding the variant found on chromosome 22 at position 42212222 in gene TCF20 (transcription factor 20): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Developmental_delay_with_variable_intellectual_impairment_and_behavioral_abnormalities']
CACTTGCCACACAGACAGCAAACCAGGTGCCCCATAACCGAAGACTCTGTCACAACAGGTCCCTGCAGCATAAAGGACGAGGCCGGGAGCGCCTTGCTTTCAGTGCTGCTAGGTGGAGGGGTCAGTGACCTCTGACCCTTCCTGCCCCTCACTAATTTGGTCTGTTCTTCTTCCTCAGCATTGATGATTGTACAAACGGCTCCAAGTTCACACTTATTTACTACATGGATGTAAGGGTAAAAAGACTTGTTCTTGGCATCAGTTTTATCCAGTGGCTGGGTGGCATATTTTAGTTTGATCTCAGGTTCTTGGGGTTCCAC...
CACTTGCCACACAGACAGCAAACCAGGTGCCCCATAACCGAAGACTCTGTCACAACAGGTCCCTGCAGCATAAAGGACGAGGCCGGGAGCGCCTTGCTTTCAGTGCTGCTAGGTGGAGGGGTCAGTGACCTCTGACCCTTCCTGCCCCTCACTAATTTGGTCTGTTCTTCTTCCTCAGCATTGATGATTGTACAAACGGCTCCAAGTTCACACTTATTTACTACATGGATGTAAGGGTAAAAAGACTTGTTCTTGGCATCAGTTTTATCCAGTGGCTGGGTGGCATATTTTAGTTTGATCTCAGGTTCTTGGGGTTCCAC...
pathogenic
327,839
Located at chromosome 22 position 42212518, the variant affecting gene TCF20 (transcription factor 20)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Inborn_genetic_diseases']
GATCTCAGGTTCTTGGGGTTCCACAATGGGAACTGCTTGTTTGGTTTTTCGCTTCCTCGGCTGGGCCCCAGGCTTCCTTCTCTCCCTCCTTTGCCTCTGTTTTTTTGGCTTTGGCTCTCCATCTGCAGAACCTTCTGGTATCTGTGGGGGCTGAGGGGGTGGAGGCGGTGGCTGCTGCTGTTTCTTTTGCTTATTCACACTACCAATGGGTCTCCCCTTCTTCTTTCCTGATGGGAAATATCCCTTTGGAGGGAAACCCTCTTGCTTCGGTGAAATCGTCACTGTATCGTTCTCCTTCTCTTCAGCCTTGGGGTTTGCCT...
GATCTCAGGTTCTTGGGGTTCCACAATGGGAACTGCTTGTTTGGTTTTTCGCTTCCTCGGCTGGGCCCCAGGCTTCCTTCTCTCCCTCCTTTGCCTCTGTTTTTTTGGCTTTGGCTCTCCATCTGCAGAACCTTCTGGTATCTGTGGGGGCTGAGGGGGTGGAGGCGGTGGCTGCTGCTGTTTCTTTTGCTTATTCACACTACCAATGGGTCTCCCCTTCTTCTTTCCTGATGGGAAATATCCCTTTGGAGGGAAACCCTCTTGCTTCGGTGAAATCGTCACTGTATCGTTCTCCTTCTCTTCAGCCTTGGGGTTTGCCT...
pathogenic
327,844
A mutation at chromosome position 42212737 on chromosome 22 in gene TCF20 (transcription factor 20): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Developmental_delay_with_variable_intellectual_impairment_and_behavioral_abnormalities']
CTTCTTTCCTGATGGGAAATATCCCTTTGGAGGGAAACCCTCTTGCTTCGGTGAAATCGTCACTGTATCGTTCTCCTTCTCTTCAGCCTTGGGGTTTGCCTCAGGGGCCAATATGCCCACTGGAGGTACATTCTTTGAGTCTGGAAAGATTAAAGGTGCTGTTCCACCCAGGGAACCATCTGGTCTCCCTTGGTTACTACCAGGCTTCTGTGAGGTTGTGGATGTCATGGCACCAGGGGGTTCCTTTCCGGCAGTAACTGTTTCTGCATGTGTCTCTGTCTTCACTTTGTCATCCACGCTGCCACGCCACTCTTCTGAAG...
CTTCTTTCCTGATGGGAAATATCCCTTTGGAGGGAAACCCTCTTGCTTCGGTGAAATCGTCACTGTATCGTTCTCCTTCTCTTCAGCCTTGGGGTTTGCCTCAGGGGCCAATATGCCCACTGGAGGTACATTCTTTGAGTCTGGAAAGATTAAAGGTGCTGTTCCACCCAGGGAACCATCTGGTCTCCCTTGGTTACTACCAGGCTTCTGTGAGGTTGTGGATGTCATGGCACCAGGGGGTTCCTTTCCGGCAGTAACTGTTTCTGCATGTGTCTCTGTCTTCACTTTGTCATCCACGCTGCCACGCCACTCTTCTGAAG...
pathogenic
327,846
Is the genetic change at chromosome 22, position 42213494, within gene TCF20 (transcription factor 20) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autism', 'Intellectual_disability,_mild']
GAGTGAAGGAGGCGACCTTTATCTTCAGTGCTACTGTTCTTTACATCTTGTGACTGTCTCTTACTGGGAATGGGAGAGATAAAAGAACGAACACGCCTCCTCATGATTAAGGGGTTTTGAGAAGAATGATCCTCCTGGCCTGGAAGTCTCAGCATAACACTACCAGGTTTGGATGACTGTGTAGCCTCAGCTAGTCCATGTCCATCAGTCTCATGGGGCGGCCCATACCTTTTTTGACTGGACATTCCTGGAGGACCGCTGCTTTTGGCTGGAGAAGTTTGCCGAGAAAGATCCCAACAGGATTCTTGTAACTTCTGGGA...
GAGTGAAGGAGGCGACCTTTATCTTCAGTGCTACTGTTCTTTACATCTTGTGACTGTCTCTTACTGGGAATGGGAGAGATAAAAGAACGAACACGCCTCCTCATGATTAAGGGGTTTTGAGAAGAATGATCCTCCTGGCCTGGAAGTCTCAGCATAACACTACCAGGTTTGGATGACTGTGTAGCCTCAGCTAGTCCATGTCCATCAGTCTCATGGGGCGGCCCATACCTTTTTTGACTGGACATTCCTGGAGGACCGCTGCTTTTGGCTGGAGAAGTTTGCCGAGAAAGATCCCAACAGGATTCTTGTAACTTCTGGGA...
pathogenic
327,858
Evaluate this variant at chromosome 22, position 42214566, gene TCF20 (transcription factor 20): benign or pathogenic? If pathogenic, what are the disease connection(s)?
benign
CTTTTATCTGCCCGCTCTGGGATTTCAGCTTGGTTTCCATGGACACCAAACCACCAGGAAGAATGACCGACTGACTTAAAGTTGGATTGAGACGGTCATTCCTCCCAATTCTGGTGTCGGCACTCATGTGTCCCAGTGAGTGAGCCCCTGGGTCCCTGACAATCTGTCTTAGTGGAGAAATATCACAGATCACTGATCTTCTTTCAGAGAGGGAACCCCCAGGCTCATGTGCTGATGACTGAGGCTCTATTTCAAACTTTCTGGGAATTGGATAGTCAGTCAAATTGATCTGTTTCATTTCAGGAGCTGTGCTGCTTGAT...
CTTTTATCTGCCCGCTCTGGGATTTCAGCTTGGTTTCCATGGACACCAAACCACCAGGAAGAATGACCGACTGACTTAAAGTTGGATTGAGACGGTCATTCCTCCCAATTCTGGTGTCGGCACTCATGTGTCCCAGTGAGTGAGCCCCTGGGTCCCTGACAATCTGTCTTAGTGGAGAAATATCACAGATCACTGATCTTCTTTCAGAGAGGGAACCCCCAGGCTCATGTGCTGATGACTGAGGCTCTATTTCAAACTTTCTGGGAATTGGATAGTCAGTCAAATTGATCTGTTTCATTTCAGGAGCTGTGCTGCTTGAT...
benign
327,871
The mutation in gene TCF20 (transcription factor 20) at chromosome 22, position 42214941—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Developmental_delay_with_variable_intellectual_impairment_and_behavioral_abnormalities', 'Neurodevelopmental_abnormality']
TCAGAAGGCCCCTGCTAGCTAATTCATTGGTTTGACTAACCAAGACATTGGGCCTTGTGGTTCCTTCTAGGCTACCAGCCATCCCCTGATGCTCTTGAGTACTCCTAGAATATCTCCTGTCAGGGTGGTGGTGGTAACCCTGAAGCACTTCCTGCAGGAGGCTTGGGAATTTTTCATTTCTACCCTTTCGTTCCCCATGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTA...
TCAGAAGGCCCCTGCTAGCTAATTCATTGGTTTGACTAACCAAGACATTGGGCCTTGTGGTTCCTTCTAGGCTACCAGCCATCCCCTGATGCTCTTGAGTACTCCTAGAATATCTCCTGTCAGGGTGGTGGTGGTAACCCTGAAGCACTTCCTGCAGGAGGCTTGGGAATTTTTCATTTCTACCCTTTCGTTCCCCATGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTA...
pathogenic
327,874
Mutation found at chromosome 22 position 42215071, gene TCF20 (transcription factor 20): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GTGGTAACCCTGAAGCACTTCCTGCAGGAGGCTTGGGAATTTTTCATTTCTACCCTTTCGTTCCCCATGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTG...
GTGGTAACCCTGAAGCACTTCCTGCAGGAGGCTTGGGAATTTTTCATTTCTACCCTTTCGTTCCCCATGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTG...
benign
327,878
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 22, position 42215138, gene TCF20 (transcription factor 20). What disease(s) is it linked to if pathogenic?
benign
TGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTGGCTGGGGAAGTGATGCATGACTGGTTTCCTTTGCCCCACCATTGCTAGGTGGCCTTTGAGTGGCTGC...
TGGCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTGGCTGGGGAAGTGATGCATGACTGGTTTCCTTTGCCCCACCATTGCTAGGTGGCCTTTGAGTGGCTGC...
benign
327,883
A genetic alteration at chromosome 22, position 42215140, in gene TCF20 (transcription factor 20)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
GCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTGGCTGGGGAAGTGATGCATGACTGGTTTCCTTTGCCCCACCATTGCTAGGTGGCCTTTGAGTGGCTGCAG...
GCCAGTGAAATCTCCCTTTTCTTGCCCTGTAGGATACTGAGGAAAGCCACTGACATTTCGTGGCACGGCTGACCCGAAACTATCTTTGTAACTATAGCGCAGACTTCCAGGAGATTTGCTAGGCTCAGTTCTGCTCGTAAAACCAGGGCCCGCTGCAGAGTGGCCACTCTGGCCATTTCCTTCTCCATTATGGTTGGAGTTGTTATCGCCATTCTTGTTTCCTTTGCTCCCTCCTCCTCCTGGAGGCTCTGGCTGGGGAAGTGATGCATGACTGGTTTCCTTTGCCCCACCATTGCTAGGTGGCCTTTGAGTGGCTGCAG...
benign
327,884
Does the variant on chromosome 22 at location 46337791 affecting gene TRMU (tRNA mitochondrial 2-thiouridylase) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
GGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTG...
GGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTG...
pathogenic
328,111
Clinical classification of chromosome 22, position 46337867, gene TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
GTGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCACCCACAGTGAGAAGCCGGCGGGCCGGGGTGGGGTGGGG...
GTGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCACCCACAGTGAGAAGCCGGCGGGCCGGGGTGGGGTGGGG...
pathogenic
328,113
Is the genetic change at chromosome 22, position 46337868, within gene TRMU (tRNA mitochondrial 2-thiouridylase) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
TGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCACCCACAGTGAGAAGCCGGCGGGCCGGGGTGGGGTGGGGA...
TGGCCGCGCTGCTGCTGAGGCGGAGAGGTGAGGCGTCCGAGGCTCCCGCCCCCCGCCGAGCGAATGTGTCCCCGGAAACCTGTCCCCGTCCGTCGTGGCGTTGTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCGCCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCACCCACAGTGAGAAGCCGGCGGGCCGGGGTGGGGTGGGGA...
pathogenic
328,114
Does the chromosome 22 mutation at position 46343269 within gene TRMU (tRNA mitochondrial 2-thiouridylase) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Aminoglycoside-induced_deafness']
GTGTCTTTTCAGAAACTGATTTTAATGTTCAGCCTCTTCAACATTTATTGATGACTGTGATATAGAAAGTTTGTTGGGTCTAGGACACAGACACAGATTGCACCTTAAGTAGTTTATAGTTTAATGAGCTTCCTGGTAACTTTCTAATAATTAAAGCAAAATGGAAAGAGTGTAATAATATCAAGTGTTGTTGCAAATGTGGAAAAACATGAGTTTTTATGAACTTCTAGGGGGACTGAGAAGTAGGAAAACAGTTTGGTGCCTGCTAAAGTGGAAGATATCCAAGGAACCTCTGACCCTGTGCAGATCTGTGATATGTC...
GTGTCTTTTCAGAAACTGATTTTAATGTTCAGCCTCTTCAACATTTATTGATGACTGTGATATAGAAAGTTTGTTGGGTCTAGGACACAGACACAGATTGCACCTTAAGTAGTTTATAGTTTAATGAGCTTCCTGGTAACTTTCTAATAATTAAAGCAAAATGGAAAGAGTGTAATAATATCAAGTGTTGTTGCAAATGTGGAAAAACATGAGTTTTTATGAACTTCTAGGGGGACTGAGAAGTAGGAAAACAGTTTGGTGCCTGCTAAAGTGGAAGATATCCAAGGAACCTCTGACCCTGTGCAGATCTGTGATATGTC...
pathogenic
328,120
Determine if the mutation at chromosome 22, position 46343340 in gene TRMU (tRNA mitochondrial 2-thiouridylase) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
TGTTGGGTCTAGGACACAGACACAGATTGCACCTTAAGTAGTTTATAGTTTAATGAGCTTCCTGGTAACTTTCTAATAATTAAAGCAAAATGGAAAGAGTGTAATAATATCAAGTGTTGTTGCAAATGTGGAAAAACATGAGTTTTTATGAACTTCTAGGGGGACTGAGAAGTAGGAAAACAGTTTGGTGCCTGCTAAAGTGGAAGATATCCAAGGAACCTCTGACCCTGTGCAGATCTGTGATATGTCTGCAAAACACAAACCTCTTGATCAGCACTGGTTTTTTTTTTAACCCTTGTTGATTAATAGAGAGTTTTAGG...
TGTTGGGTCTAGGACACAGACACAGATTGCACCTTAAGTAGTTTATAGTTTAATGAGCTTCCTGGTAACTTTCTAATAATTAAAGCAAAATGGAAAGAGTGTAATAATATCAAGTGTTGTTGCAAATGTGGAAAAACATGAGTTTTTATGAACTTCTAGGGGGACTGAGAAGTAGGAAAACAGTTTGGTGCCTGCTAAAGTGGAAGATATCCAAGGAACCTCTGACCCTGTGCAGATCTGTGATATGTCTGCAAAACACAAACCTCTTGATCAGCACTGGTTTTTTTTTTAACCCTTGTTGATTAATAGAGAGTTTTAGG...
pathogenic
328,123
Benign or pathogenic: chromosome 22, position 46346419, gene TRMU (tRNA mitochondrial 2-thiouridylase) variant? Disease(s) if pathogenic?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
GAGTGATAGACTGATAGAATGTGAATTGATTTTTATTTTCAGGGTATCTGGAAATATGTCCTCCCTGAACTGTTGAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTT...
GAGTGATAGACTGATAGAATGTGAATTGATTTTTATTTTCAGGGTATCTGGAAATATGTCCTCCCTGAACTGTTGAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTT...
pathogenic
328,128
Does the chromosome 22 mutation at position 46346460 within gene TRMU (tRNA mitochondrial 2-thiouridylase) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Aminoglycoside-induced_deafness']
GGGTATCTGGAAATATGTCCTCCCTGAACTGTTGAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATG...
GGGTATCTGGAAATATGTCCTCCCTGAACTGTTGAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATG...
pathogenic
328,130
Assess the variant on chromosome 22, position 46346493, impacting TRMU (tRNA mitochondrial 2-thiouridylase): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Aminoglycoside-induced_deafness']
GAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATGAGAGGACATGACGCCCAGACTTCTGAACTCACC...
GAAATTACTTTGGGTCGTAGTGGCAGTGGTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATGAGAGGACATGACGCCCAGACTTCTGAACTCACC...
pathogenic
328,131
Mutation at chromosome 22, position 46346521, within TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Aminoglycoside-induced_deafness']
GTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATGAGAGGACATGACGCCCAGACTTCTGAACTCACCGCGCTTCTCAGAGGCATCCTGCGCTTTT...
GTCAAGCGTGTGAGTTAGGATGACATTCTTTGTGTGACACCAGCAGACAGTTAGGACTGGCAGGAGAAAGAGTTCCCTGAGGTGGAGGCGCAGGCAGCTGTTCAGGAAGGGAAGGCTTGCCTTTGGAGAGCATTAAGCTGTCACGAAAGCTTTTTAGGGAGCCCCTAGGTGGCTGGCTGTCAGGCACGCTGTGGAAGGAACTTCTGCAGTGAATGTTTCCACACCTGGAAGAAAGGCATGAACCGTGCAGCACAGGATGAGAGGACATGACGCCCAGACTTCTGAACTCACCGCGCTTCTCAGAGGCATCCTGCGCTTTT...
pathogenic
328,133
Evaluate this variant at chromosome 22, position 46350387, gene TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
GTGCGTTTGGCATGTGGGAATTGTGATGGTGCACAGTGTCTTGGCCTTCACTGGGTTTTGTAGGCACACTAAGGTTTCCATTTCATTCTTCTTCAGTTGCCCTGGCCCAGCCTGGGTCTCTGGGTAGAGCACCTGCAGGGGCAGTGGACGGCCTGGGCTCAGGGTCGGTCAGCACCTGAGACCAGCGCTCCTAGGCCTGGCCTGTGACTGGGCTGATTTTCCCCCACACAGCGTGCTACCACCGGCCTGGCAGAGCCAGCACGGCAGCCGGCGTGTCAGTGAGGCTCCAGCACAGGCAGCCTCCTCCAAATGTTGTTCAT...
GTGCGTTTGGCATGTGGGAATTGTGATGGTGCACAGTGTCTTGGCCTTCACTGGGTTTTGTAGGCACACTAAGGTTTCCATTTCATTCTTCTTCAGTTGCCCTGGCCCAGCCTGGGTCTCTGGGTAGAGCACCTGCAGGGGCAGTGGACGGCCTGGGCTCAGGGTCGGTCAGCACCTGAGACCAGCGCTCCTAGGCCTGGCCTGTGACTGGGCTGATTTTCCCCCACACAGCGTGCTACCACCGGCCTGGCAGAGCCAGCACGGCAGCCGGCGTGTCAGTGAGGCTCCAGCACAGGCAGCCTCCTCCAAATGTTGTTCAT...
pathogenic
328,141
Is the genetic variant on chromosome 22, position 46350387, gene TRMU (tRNA mitochondrial 2-thiouridylase), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Aminoglycoside-induced_deafness']
GTGCGTTTGGCATGTGGGAATTGTGATGGTGCACAGTGTCTTGGCCTTCACTGGGTTTTGTAGGCACACTAAGGTTTCCATTTCATTCTTCTTCAGTTGCCCTGGCCCAGCCTGGGTCTCTGGGTAGAGCACCTGCAGGGGCAGTGGACGGCCTGGGCTCAGGGTCGGTCAGCACCTGAGACCAGCGCTCCTAGGCCTGGCCTGTGACTGGGCTGATTTTCCCCCACACAGCGTGCTACCACCGGCCTGGCAGAGCCAGCACGGCAGCCGGCGTGTCAGTGAGGCTCCAGCACAGGCAGCCTCCTCCAAATGTTGTTCAT...
GTGCGTTTGGCATGTGGGAATTGTGATGGTGCACAGTGTCTTGGCCTTCACTGGGTTTTGTAGGCACACTAAGGTTTCCATTTCATTCTTCTTCAGTTGCCCTGGCCCAGCCTGGGTCTCTGGGTAGAGCACCTGCAGGGGCAGTGGACGGCCTGGGCTCAGGGTCGGTCAGCACCTGAGACCAGCGCTCCTAGGCCTGGCCTGTGACTGGGCTGATTTTCCCCCACACAGCGTGCTACCACCGGCCTGGCAGAGCCAGCACGGCAGCCGGCGTGTCAGTGAGGCTCCAGCACAGGCAGCCTCCTCCAAATGTTGTTCAT...
pathogenic
328,142
Evaluate if the mutation on chromosome 22 at position 46352160 in TRMU (tRNA mitochondrial 2-thiouridylase) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Aminoglycoside-induced_deafness']
GTGCGAATTTTTCTTACATTAACCCGTGGTGGTCTTTTCCCTAGTAGTTGCTATTGAGTGTTGATGTCTGCCTCTGACAGGCTAGGGGTAGTCTGTCTAAGTGAACAGAAGGACATTGTTGAAAGTGAAGTATCATTATTTTTATTCCTGCATCGTCTTTTGTTCTTTATTCTTGGCAGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGACCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAGAACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCGCTGCTGAGA...
GTGCGAATTTTTCTTACATTAACCCGTGGTGGTCTTTTCCCTAGTAGTTGCTATTGAGTGTTGATGTCTGCCTCTGACAGGCTAGGGGTAGTCTGTCTAAGTGAACAGAAGGACATTGTTGAAAGTGAAGTATCATTATTTTTATTCCTGCATCGTCTTTTGTTCTTTATTCTTGGCAGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGACCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAGAACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCGCTGCTGAGA...
pathogenic
328,150
For chromosome 22, position 46352268, gene TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins']
AAGGACATTGTTGAAAGTGAAGTATCATTATTTTTATTCCTGCATCGTCTTTTGTTCTTTATTCTTGGCAGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGACCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAGAACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCGCTGCTGAGAATAGACTTCATCATGTGCTTCAGAAGAAAGAGGTACGAGTGAGCAGTTGCCTTTGATTAGTGCCTGTTTCCCTTTCCCGACTGCATGGCACGGAGCAGCTGGACCTGT...
AAGGACATTGTTGAAAGTGAAGTATCATTATTTTTATTCCTGCATCGTCTTTTGTTCTTTATTCTTGGCAGCGGTAAAACTCCTCCAGGCAGCTGACAGCTTTAAAGACCAGACCTTCTTTCTCAGCCAGGTTTCCCAGGATGCCCTGAGGAGAACCATCTTCCCTCTGGGGGGATTAACGAAAGAGTTTGTAAAGAAAATCGCTGCTGAGAATAGACTTCATCATGTGCTTCAGAAGAAAGAGGTACGAGTGAGCAGTTGCCTTTGATTAGTGCCTGTTTCCCTTTCCCGACTGCATGGCACGGAGCAGCTGGACCTGT...
pathogenic
328,155
Gene TRMU (tRNA mitochondrial 2-thiouridylase) variant at chromosome 22, position 46353796—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
GCCTTAGCTTCAGGCCTGGCTTTCCTGCTACCTGCCCCTTCTCTGGTCCCTGTCTCTCCCCCACTCCTCGCAGGACAGTGGCCTGAAGGACCTGACCGGGTTCTGCTTTCTTCCCCGGGGCAGCTGGTGTGAGGGTCTCCCGCGCAGGGTCAGACCCCGCGGGCCGAGACAATGAGGCGTTCTCTAAGGCTCTGGCATCGTGTGCGCCGGCTGTGACTGGCGGCCGAGGGTGCCGGTGGGCAGCCGGGCCCCTACCCTGGAAGCAAAGTGTGGGGTGAGGCCGGGAGGCCCCAGGGCCCGCTCAGGACGTCTGGGTACAG...
GCCTTAGCTTCAGGCCTGGCTTTCCTGCTACCTGCCCCTTCTCTGGTCCCTGTCTCTCCCCCACTCCTCGCAGGACAGTGGCCTGAAGGACCTGACCGGGTTCTGCTTTCTTCCCCGGGGCAGCTGGTGTGAGGGTCTCCCGCGCAGGGTCAGACCCCGCGGGCCGAGACAATGAGGCGTTCTCTAAGGCTCTGGCATCGTGTGCGCCGGCTGTGACTGGCGGCCGAGGGTGCCGGTGGGCAGCCGGGCCCCTACCCTGGAAGCAAAGTGTGGGGTGAGGCCGGGAGGCCCCAGGGCCCGCTCAGGACGTCTGGGTACAG...
pathogenic
328,166
Is the genetic mutation found on chromosome 22 at position 46353812, within the gene TRMU (tRNA mitochondrial 2-thiouridylase), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Aminoglycoside-induced_deafness']
TGGCTTTCCTGCTACCTGCCCCTTCTCTGGTCCCTGTCTCTCCCCCACTCCTCGCAGGACAGTGGCCTGAAGGACCTGACCGGGTTCTGCTTTCTTCCCCGGGGCAGCTGGTGTGAGGGTCTCCCGCGCAGGGTCAGACCCCGCGGGCCGAGACAATGAGGCGTTCTCTAAGGCTCTGGCATCGTGTGCGCCGGCTGTGACTGGCGGCCGAGGGTGCCGGTGGGCAGCCGGGCCCCTACCCTGGAAGCAAAGTGTGGGGTGAGGCCGGGAGGCCCCAGGGCCCGCTCAGGACGTCTGGGTACAGCTTGGGCCACCGCCAC...
TGGCTTTCCTGCTACCTGCCCCTTCTCTGGTCCCTGTCTCTCCCCCACTCCTCGCAGGACAGTGGCCTGAAGGACCTGACCGGGTTCTGCTTTCTTCCCCGGGGCAGCTGGTGTGAGGGTCTCCCGCGCAGGGTCAGACCCCGCGGGCCGAGACAATGAGGCGTTCTCTAAGGCTCTGGCATCGTGTGCGCCGGCTGTGACTGGCGGCCGAGGGTGCCGGTGGGCAGCCGGGCCCCTACCCTGGAAGCAAAGTGTGGGGTGAGGCCGGGAGGCCCCAGGGCCCGCTCAGGACGTCTGGGTACAGCTTGGGCCACCGCCAC...
pathogenic
328,167
Evaluate this variant at chromosome 22, position 46355444, gene TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
ACACTGTGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACA...
ACACTGTGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACA...
pathogenic
328,176
Gene mutation in TRMU (tRNA mitochondrial 2-thiouridylase) at chromosome 22, position 46355446—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
ACTGTGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACATG...
ACTGTGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACATG...
pathogenic
328,177
Is the variant located on chromosome 22 at position 46355450, gene TRMU (tRNA mitochondrial 2-thiouridylase), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins', 'Aminoglycoside-induced_deafness']
TGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACATGTGGG...
TGAAGACGTGCAGCTATGTCATGGGCTCAGCAAGAAGGGCCCCTGGCGTCACACAGGGCACCCAGCCGCATCCTGGGCCTAGGGTCAGGGGCTCCTACAGCTGGAACCTGCACCTTCTGGGGCACAAGGTGCCTTCTTTGTGGCCACCACACCCCATGTCCAGCCCAGGCCTGGACAATGATGAGATGTGCTCAGGTGCTTGGTCAGGGCTGGCTTTGGTGGTTGGAGAATCGTATCTTCCTAGTGAGTTACACCATTGCTGGGCCTGCTCTGGGCTGCCCTCCCAGCATCTGCCTTCATGATGAGGCGTGACATGTGGG...
pathogenic
328,178
The genetic variant at chromosome 22, position 46356007, affecting gene TRMU (tRNA mitochondrial 2-thiouridylase): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Aminoglycoside-induced_deafness']
CCGTGGCTTCCTGGAGGCTGTGACTAACTCTGTTCCTGTCCTTGGTCCCCTGCCTTTCCTGGGACTGGCCATGGTGGCAGGAGAGTTTTAAGGTATTCATTAGGCTGAGTTGTATGCTGGTCTCTTAATCATCCCTGAACCCCGATACACAGATACAGTTTCTCCAATTTTATGAAAGAGGACAGCGACGCCCAGAGCTTGGGTGGCTCATCCGGTGGAGAGGGCATGGCCTCAGTGCCAAGGATGGTGCCCACCATGGTAGGATCCAGTGAGTTGTTGTCAGGCAGGTGCAGATGGCCAAGCCAGGATCAAACCAAGCC...
CCGTGGCTTCCTGGAGGCTGTGACTAACTCTGTTCCTGTCCTTGGTCCCCTGCCTTTCCTGGGACTGGCCATGGTGGCAGGAGAGTTTTAAGGTATTCATTAGGCTGAGTTGTATGCTGGTCTCTTAATCATCCCTGAACCCCGATACACAGATACAGTTTCTCCAATTTTATGAAAGAGGACAGCGACGCCCAGAGCTTGGGTGGCTCATCCGGTGGAGAGGGCATGGCCTCAGTGCCAAGGATGGTGCCCACCATGGTAGGATCCAGTGAGTTGTTGTCAGGCAGGTGCAGATGGCCAAGCCAGGATCAAACCAAGCC...
pathogenic
328,185
A genetic variant at chromosome 22, position 49904057, affecting gene ALG12 (ALG12 alpha-1,6-mannosyltransferase)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
ATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAACGTACACGTGTGCACTGTGTGTGGTGTGCATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTGTGTGCATGTGTGCACTGTATGCATAGTGTGCACGTGTGCACTGTGTGTGGATGCATGGTAATGTG...
ATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAACGTACACGTGTGCACTGTGTGTGGTGTGCATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTGTGTGCATGTGTGCACTGTATGCATAGTGTGCACGTGTGCACTGTGTGTGGATGCATGGTAATGTG...
pathogenic
328,271
A mutation at chromosome position 49904342 on chromosome 22 in gene ALG12 (ALG12 alpha-1,6-mannosyltransferase): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
CACGTGTGCACTGTGTGTGGATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACGGTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGT...
CACGTGTGCACTGTGTGTGGATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACGGTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGT...
pathogenic
328,274
A genetic alteration at chromosome 22, position 49904497, in gene ALG12 (ALG12 alpha-1,6-mannosyltransferase)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['ALG12-congenital_disorder_of_glycosylation', 'Inborn_genetic_diseases']
GTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATAGTGTGTGCACGTGTGCACTGTGTGTGGATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGC...
GTGTATGCATGGTGTGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACATGTGCACTGTGTATGCATGGTAATGTGCACGCGTGCACTGTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATGGTAATGTGCACGTGTGCACTGTGTGGTGTGTATGCATGGTGTGTGCACGTGTGCACTGTGTATGCATAGTGTGTGCACGTGTGCACTGTGTGTGGATGCATGGTAATGTGCACGTGTGCACTGTGTGTGGTGTGTATGC...
pathogenic
328,276
Does the variant impacting ALG12 (ALG12 alpha-1,6-mannosyltransferase) on chromosome 22, position 49907781, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
TCTTTATAAATTATCCAGTCTCAGGTGTTTCTTTACATCAGTGCGAGAGCAGACTAGTGCACCCTTGAACAATCTCTGGTGCGGTTTCTGAGCTCGAGGCCCCACCTAGGATGACCGCAGCCTCCTAAGTGCCTGCCCCAAAGAGCTCAGCACTGCCAGGGCGTTCGTCCTTTGTTCCCGCCCAAACCTGGAGTGGGCAGTCACTGTGGAAAGCTCGCAATCAGAAACCTTCCACCCCCAGGACTGTCTCAAGGCCCTGGGCCCTGACACCGTGGGAAACGGCCTGCTCTTGCTCCCAGGGTGGCCGGGCTGAGGACCTG...
TCTTTATAAATTATCCAGTCTCAGGTGTTTCTTTACATCAGTGCGAGAGCAGACTAGTGCACCCTTGAACAATCTCTGGTGCGGTTTCTGAGCTCGAGGCCCCACCTAGGATGACCGCAGCCTCCTAAGTGCCTGCCCCAAAGAGCTCAGCACTGCCAGGGCGTTCGTCCTTTGTTCCCGCCCAAACCTGGAGTGGGCAGTCACTGTGGAAAGCTCGCAATCAGAAACCTTCCACCCCCAGGACTGTCTCAAGGCCCTGGGCCCTGACACCGTGGGAAACGGCCTGCTCTTGCTCCCAGGGTGGCCGGGCTGAGGACCTG...
pathogenic
328,280
Is the chromosome 22, position 49909242 variant in ALG12 (ALG12 alpha-1,6-mannosyltransferase) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
CTTCCTCTACCTGACCTGTCGCCCTCAGAGCCTCCCAGGCCTGGCTGCCCCTGCCCTCTGCCGCTGCTACCTATGTGAGTGTCACTCTCCCATGACAGAGACTGGGACCGCTGGTGCATCACCATATGTGGACCAGTCACCAAATTAACCCAAGACAGAGACCACCTGAGCAAAGCCCTCTGTCAGCACAATGCCAGGCCGGTCCCATCCCATGCAGCCCTCAGGGAGGAGAGAGGACTGGGGTCACCCTCCTTTGACATAAGCGCCTAGTTCAACACACCCTGTGTTTATCTTAAAAAACAGCCCTGGTGGCTCACACC...
CTTCCTCTACCTGACCTGTCGCCCTCAGAGCCTCCCAGGCCTGGCTGCCCCTGCCCTCTGCCGCTGCTACCTATGTGAGTGTCACTCTCCCATGACAGAGACTGGGACCGCTGGTGCATCACCATATGTGGACCAGTCACCAAATTAACCCAAGACAGAGACCACCTGAGCAAAGCCCTCTGTCAGCACAATGCCAGGCCGGTCCCATCCCATGCAGCCCTCAGGGAGGAGAGAGGACTGGGGTCACCCTCCTTTGACATAAGCGCCTAGTTCAACACACCCTGTGTTTATCTTAAAAAACAGCCCTGGTGGCTCACACC...
pathogenic
328,284
A genetic variant at chromosome 22, position 49913648, affecting gene ALG12 (ALG12 alpha-1,6-mannosyltransferase)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
AATTTTTGTATTTTTAGTAGAGACAAGGTTTCCCATGTTGGCCAGGATGGTCTCAAACTCCTGACCTCAGGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGTCTGAATGTCTTAATAGGACATTTTTCACTGATACTCACAAGTGGGTCTGGCTCCAGCTGCTGTATTTTTGGTGCTGGAATTTCCCCCGGGCTTTTAAACAATTCACAGACCCCAGCAAAGCCCCGCTTCCCCTTTTCCCCATCAGGTCCATCCCCTGCGTCTCTTCTCTTGGTTTTCCATCTTCCCA...
AATTTTTGTATTTTTAGTAGAGACAAGGTTTCCCATGTTGGCCAGGATGGTCTCAAACTCCTGACCTCAGGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGTCTGAATGTCTTAATAGGACATTTTTCACTGATACTCACAAGTGGGTCTGGCTCCAGCTGCTGTATTTTTGGTGCTGGAATTTCCCCCGGGCTTTTAAACAATTCACAGACCCCAGCAAAGCCCCGCTTCCCCTTTTCCCCATCAGGTCCATCCCCTGCGTCTCTTCTCTTGGTTTTCCATCTTCCCA...
pathogenic
328,304
Does the variant on chromosome 22 at location 49913735 affecting gene ALG12 (ALG12 alpha-1,6-mannosyltransferase) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['ALG12-congenital_disorder_of_glycosylation']
GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGTCTGAATGTCTTAATAGGACATTTTTCACTGATACTCACAAGTGGGTCTGGCTCCAGCTGCTGTATTTTTGGTGCTGGAATTTCCCCCGGGCTTTTAAACAATTCACAGACCCCAGCAAAGCCCCGCTTCCCCTTTTCCCCATCAGGTCCATCCCCTGCGTCTCTTCTCTTGGTTTTCCATCTTCCCAAATGCCCAACAATCTCAACCCCGTGCCCAACAAGGGTAGCCTCGGCCTCACGATCAGCCTCGGCTGCGGGATCACCCTCGGCCCCGG...
GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGTCTGAATGTCTTAATAGGACATTTTTCACTGATACTCACAAGTGGGTCTGGCTCCAGCTGCTGTATTTTTGGTGCTGGAATTTCCCCCGGGCTTTTAAACAATTCACAGACCCCAGCAAAGCCCCGCTTCCCCTTTTCCCCATCAGGTCCATCCCCTGCGTCTCTTCTCTTGGTTTTCCATCTTCCCAAATGCCCAACAATCTCAACCCCGTGCCCAACAAGGGTAGCCTCGGCCTCACGATCAGCCTCGGCTGCGGGATCACCCTCGGCCCCGG...
pathogenic
328,308
Evaluate if the mutation on chromosome 22 at position 50064040 in MLC1 (modulator of VRAC current 1) is benign or pathogenic. Disease name(s) if pathogenic?
benign
GAAAACACTTAAGGCAGAGGTAACCAGATGCCTCCAGGCAAAAGGGAGGACAGCGCCAGCCCCAGCTGTCCACCCTGAGCCCCAGTTGTCCACCCTGAGCCCCAGCTGTCCACCCTGAGCCCCAGTTGTCCACCCTGAGCCCCAGCCACCCACCCTGAGCCCCTGGGCCCCAGCCGTCCACCCTAAGCCCCAGCCATCCACCCTGAGCCCCAGCCGTCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAACCGCCCACCCTGAGCCCAAGCCACCCACCTTGAGCCCCAGCCGTCCATCCTGAGCCCCAGCCGCCCA...
GAAAACACTTAAGGCAGAGGTAACCAGATGCCTCCAGGCAAAAGGGAGGACAGCGCCAGCCCCAGCTGTCCACCCTGAGCCCCAGTTGTCCACCCTGAGCCCCAGCTGTCCACCCTGAGCCCCAGTTGTCCACCCTGAGCCCCAGCCACCCACCCTGAGCCCCTGGGCCCCAGCCGTCCACCCTAAGCCCCAGCCATCCACCCTGAGCCCCAGCCGTCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAACCGCCCACCCTGAGCCCAAGCCACCCACCTTGAGCCCCAGCCGTCCATCCTGAGCCCCAGCCGCCCA...
benign
328,341
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 22, position 50064175, gene MLC1 (modulator of VRAC current 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
TGAGCCCCAGCCACCCACCCTGAGCCCCTGGGCCCCAGCCGTCCACCCTAAGCCCCAGCCATCCACCCTGAGCCCCAGCCGTCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAACCGCCCACCCTGAGCCCAAGCCACCCACCTTGAGCCCCAGCCGTCCATCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCTGGGACCAGCAGTTCTGGGATCTGGGGAGAACACCTCATGCGTCTGACTCTGGGCCTTGCTGGTCACAACAGAAACCCAGGCGGGTCTCATTTCAGGCCCAGGG...
TGAGCCCCAGCCACCCACCCTGAGCCCCTGGGCCCCAGCCGTCCACCCTAAGCCCCAGCCATCCACCCTGAGCCCCAGCCGTCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAACCGCCCACCCTGAGCCCAAGCCACCCACCTTGAGCCCCAGCCGTCCATCCTGAGCCCCAGCCGCCCACCCTGAGCCCCAGCCGCCCACCCTGAGCCCCTGGGACCAGCAGTTCTGGGATCTGGGGAGAACACCTCATGCGTCTGACTCTGGGCCTTGCTGGTCACAACAGAAACCCAGGCGGGTCTCATTTCAGGCCCAGGG...
pathogenic
328,351
A genetic alteration at chromosome 22, position 50068477, in gene MLC1 (modulator of VRAC current 1)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
ACAGGCAGATCACTTAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTGCTAAAAGTACAAAAATTAGCCGGGTGTGTTGGCATATGCCTGTAATCCCAGATGCTCCGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGACTGTGCCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCTATCTTAAAAAAAAAAAAATGGCAAGGTACAGAATAGTGATTCTAGTATACAAGCTATTTTGTAAGAAAGAAAAAAAAATTATCATCTGGTTGCC...
ACAGGCAGATCACTTAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTGCTAAAAGTACAAAAATTAGCCGGGTGTGTTGGCATATGCCTGTAATCCCAGATGCTCCGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGACTGTGCCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCTATCTTAAAAAAAAAAAAATGGCAAGGTACAGAATAGTGATTCTAGTATACAAGCTATTTTGTAAGAAAGAAAAAAAAATTATCATCTGGTTGCC...
pathogenic
328,365
A genetic variant on chromosome 22, position 50070543, affects the gene MLC1 (modulator of VRAC current 1). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
ATCCAGAGGCTGTGAACAGCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGC...
ATCCAGAGGCTGTGAACAGCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGC...
pathogenic
328,377
Does the genetic variant at chromosome 22, position 50070544, impacting gene MLC1 (modulator of VRAC current 1), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
TCCAGAGGCTGTGAACAGCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGCC...
TCCAGAGGCTGTGAACAGCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGCC...
pathogenic
328,378
Regarding the variant at chromosome 22 and position 50070561, affecting gene MLC1 (modulator of VRAC current 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
GCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGTGAT...
GCAGCGGAGACGTGAGGCTGCTTATGGCAATCAGGACCTCCACCTGGAAAAAAAGCGCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCCAAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCTTTTCTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAAGTCTCGCTGTGTCGCCAGGCTGGAATGCAGTGGCATGATCTTGGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGTGAT...
pathogenic
328,379
Is the chromosome 22, position 50074290 variant in MLC1 (modulator of VRAC current 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
CAGCCATAGGGGCTGGGGCAGCTCAATCAAGGGCCCTGCCCTGGAAGGGTCCAGGCCTGCAGCCCAGCCCCCAACTCCAGCCCCGAGCACCTGCCTCCAGCCCATGGTGCAGGGCCTGGGCCCCTCTGCCGCACCCAGGCCAGACTCAGGCAGGTGGAGCTGGGTCCCTCACCACGCATGCCTCAGCGCTCTCCTCTCCTCCTGGGGTCTCCTGCCCTGAAGAGAGGGTTGGGAGTGTGGGTGGATTTAGGGGCGCCCAGGGGGCAGCACCTGATGGGCAGGGGGTGCTCTCCGGGAAGATGGAGAGAGCAGAGCCACCC...
CAGCCATAGGGGCTGGGGCAGCTCAATCAAGGGCCCTGCCCTGGAAGGGTCCAGGCCTGCAGCCCAGCCCCCAACTCCAGCCCCGAGCACCTGCCTCCAGCCCATGGTGCAGGGCCTGGGCCCCTCTGCCGCACCCAGGCCAGACTCAGGCAGGTGGAGCTGGGTCCCTCACCACGCATGCCTCAGCGCTCTCCTCTCCTCCTGGGGTCTCCTGCCCTGAAGAGAGGGTTGGGAGTGTGGGTGGATTTAGGGGCGCCCAGGGGGCAGCACCTGATGGGCAGGGGGTGCTCTCCGGGAAGATGGAGAGAGCAGAGCCACCC...
pathogenic
328,385
Gene MLC1 (modulator of VRAC current 1) variant at chromosome 22, position 50076840—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts', 'Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
ACACTGGACGTCACCACCCCTTTCCGTGGCAATGATCCAACCACCTGGACGTTAGCACCCCTTTTCTAGAAATTTCTGCATAATCTGCCCCTTAATTAGCATATACTTAAAAGTGGGTATAAATAGGAGGCAGAGCTGTCTCTGAGCTGCTGCTCGAGGCACCTGCCGGTTGGAGAGCCCTGCTATACTGCCACTGCAAACAAAGCTGCTGTCTGTCACCTCCAGCTCGCCCTTGAATTCTTTCCTGGACAAAGCCAAGAACCCTGCTGGCCTAAGCCCTGGTTGTGGACTCATCTGCCCGGCACCATCAGGGCCGCAAC...
ACACTGGACGTCACCACCCCTTTCCGTGGCAATGATCCAACCACCTGGACGTTAGCACCCCTTTTCTAGAAATTTCTGCATAATCTGCCCCTTAATTAGCATATACTTAAAAGTGGGTATAAATAGGAGGCAGAGCTGTCTCTGAGCTGCTGCTCGAGGCACCTGCCGGTTGGAGAGCCCTGCTATACTGCCACTGCAAACAAAGCTGCTGTCTGTCACCTCCAGCTCGCCCTTGAATTCTTTCCTGGACAAAGCCAAGAACCCTGCTGGCCTAAGCCCTGGTTGTGGACTCATCTGCCCGGCACCATCAGGGCCGCAAC...
pathogenic
328,391
Variant at chromosome 22, position 50077470, gene MLC1 (modulator of VRAC current 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
GAATTCCCAGCCAGGCACGGCGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCAGACGGATCGTGAGGTCAGGAGTTTGAGTACAGCCTGGCCAACATGGTAAACCCCGTCTCTACTAAAAATAACAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATCGCTTCAACTCAGGAGGCAGAGGTTGCAGTGAACCAAGATCACACCACTGCACTCTAGCCTGGGCAACAGCAGGACTCCATCTCAAAAAAAAAGGAAAAAAAAAAAAGAAGCAGAACG...
GAATTCCCAGCCAGGCACGGCGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCAGACGGATCGTGAGGTCAGGAGTTTGAGTACAGCCTGGCCAACATGGTAAACCCCGTCTCTACTAAAAATAACAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATCGCTTCAACTCAGGAGGCAGAGGTTGCAGTGAACCAAGATCACACCACTGCACTCTAGCCTGGGCAACAGCAGGACTCCATCTCAAAAAAAAAGGAAAAAAAAAAAAGAAGCAGAACG...
pathogenic
328,404
Benign or pathogenic: chromosome 22, position 50080016, gene MLC1 (modulator of VRAC current 1) variant? Disease(s) if pathogenic?
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
AAAGTCAGTGTAGCTGTCTGACAATTTTTTTTTTTTTTTTGAGACGGAGGTTCGCTCTTGTTGCCCAGGCTGGAGAGCAAATGGCGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAATGATTGTCCTGCCTCAGCCTCCCGAGTAAGCTGGGGTTACAGGCACCTACCAGCACGCCCGGCTAATTTTGTATTTTTAGTAGAGAGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGTTCCGCCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCG...
AAAGTCAGTGTAGCTGTCTGACAATTTTTTTTTTTTTTTTGAGACGGAGGTTCGCTCTTGTTGCCCAGGCTGGAGAGCAAATGGCGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAATGATTGTCCTGCCTCAGCCTCCCGAGTAAGCTGGGGTTACAGGCACCTACCAGCACGCCCGGCTAATTTTGTATTTTTAGTAGAGAGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGTTCCGCCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCG...
pathogenic
328,410
Is the genetic change at chromosome 22, position 50084724, within gene MLC1 (modulator of VRAC current 1) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
TGTTTTGAGACGAAGTTTCACTCTCATTGCCCAGGCTGGAGTGCAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTG...
TGTTTTGAGACGAAGTTTCACTCTCATTGCCCAGGCTGGAGTGCAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTG...
pathogenic
328,429
The mutation in gene MLC1 (modulator of VRAC current 1) at chromosome 22, position 50084766—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts', 'Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
GCAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTGACAGAAACCTGCACATCTCAGAACAAAGAAACCAGAGCACGT...
GCAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTGACAGAAACCTGCACATCTCAGAACAAAGAAACCAGAGCACGT...
pathogenic
328,431
Clinical significance of chromosome 22, position 50084767, gene MLC1 (modulator of VRAC current 1): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Megalencephalic_leukoencephalopathy_with_subcortical_cysts', 'Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1']
CAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTGACAGAAACCTGCACATCTCAGAACAAAGAAACCAGAGCACGTG...
CAGTGGCACAATCTGGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAGTACAGGCACCCACCACCGCGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTGTCCATGTTGGTCAGACTGGTCTCAAACACCTGACCTCAGGTGATCCACCCACCTCCACCCCTCAAAGTGCTGGCATGACAGCCATGAGCCACTGTGCCCGGCCCATATGAAGAGGTTTGAATGAGGTACAGGTGACAGAAACCTGCACATCTCAGAACAAAGAAACCAGAGCACGTG...
pathogenic
328,432
Gene TUBGCP6 (tubulin gamma complex component 6) variant at chromosome 22, position 50218403—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic
ACCTGGACCCTTCTGGAAATGAGGGAAGTGCTAACAGCAGTGCCCATCCCACAAGCATTAAACTCGGGAGGTGGAGACTCTCCAGCAGAAAGCTGGGCAGCAGAGTGGTCCTGCCCCTCGGCCCACAAAGGGCCTTGGCCGAGCATGGGCATGCCTGGTGTGTGCCCACTGGGGTCCATCCCTGCCAGTGGGGTTCCAGGGACCTCGGGGACCGGGCTGCTTGGGCCCTTGGACTCTAGGTGAGCCGTGAGAGCGGGCTGGGGCAGGCGGAGCAGCTGCCTGCAGGGCAGGGACACGGTCAGGGGCTACCTCCCAGACAC...
ACCTGGACCCTTCTGGAAATGAGGGAAGTGCTAACAGCAGTGCCCATCCCACAAGCATTAAACTCGGGAGGTGGAGACTCTCCAGCAGAAAGCTGGGCAGCAGAGTGGTCCTGCCCCTCGGCCCACAAAGGGCCTTGGCCGAGCATGGGCATGCCTGGTGTGTGCCCACTGGGGTCCATCCCTGCCAGTGGGGTTCCAGGGACCTCGGGGACCGGGCTGCTTGGGCCCTTGGACTCTAGGTGAGCCGTGAGAGCGGGCTGGGGCAGGCGGAGCAGCTGCCTGCAGGGCAGGGACACGGTCAGGGGCTACCTCCCAGACAC...
pathogenic
328,458
Evaluate the clinical significance of the mutation at chromosome 22, position 50219957 in gene TUBGCP6 (tubulin gamma complex component 6): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Microcephaly_and_chorioretinopathy_1']
GGGCCTCACCTTTGAAGAGAAAGTGGGAGTAGTACTTGAAGGTGTTGTAGGACTGCTGCATGAGTGCAAAGTTGGGGTGCTCTGCACCCCGCGGGCCCCCAGGGGGCCCCCAGGCCTGGGAGATGAGCTGGCTGCGGAACTTGAGCACGAGGCTGAAGATGCTGTGGATGACGTTCATGACGGGCGCCGCCTTCTCCGTGAGCAGGCCCCTGGGGGGAAGCAGTGCTGCTGGGTGGGCTGAGCCGTGACCACAGGGACGCAGCCGCTGCCCAGGCCTCACCTGAAGACGGCCTTGTGCAGGTACTCTGCGTGCGCACGCT...
GGGCCTCACCTTTGAAGAGAAAGTGGGAGTAGTACTTGAAGGTGTTGTAGGACTGCTGCATGAGTGCAAAGTTGGGGTGCTCTGCACCCCGCGGGCCCCCAGGGGGCCCCCAGGCCTGGGAGATGAGCTGGCTGCGGAACTTGAGCACGAGGCTGAAGATGCTGTGGATGACGTTCATGACGGGCGCCGCCTTCTCCGTGAGCAGGCCCCTGGGGGGAAGCAGTGCTGCTGGGTGGGCTGAGCCGTGACCACAGGGACGCAGCCGCTGCCCAGGCCTCACCTGAAGACGGCCTTGTGCAGGTACTCTGCGTGCGCACGCT...
pathogenic
328,483
Clinical classification of chromosome 22, position 50220243, gene TUBGCP6 (tubulin gamma complex component 6): benign or pathogenic? Disease(s) if pathogenic?
benign
ACGGCCTTGTGCAGGTACTCTGCGTGCGCACGCTGGATCTCCTCCAGGTCGCCCACGGTGGCCAACCTGGCCCTGAACTCGCACCAGGTGACGTGCAGGATCTGGTTGGCGATGTAGCCCTGGATGACCTTCACGAAATGCTGCATCTCGTGCTTGAACAGCTGCAGCTGACGGAACTGCACAGAGCCGGCCATGTGGCTCAGCAGGGCTGGCGGAGGGCAGAAGGCAGAGGGCAGAGGTGAGCGCAGCCTCCAGCCAGGGGTGCGGGGCGCCGGGCTCCAGCGGGGCCTCACCTGTGCGCTTGAGGTGGAAGCAGACGT...
ACGGCCTTGTGCAGGTACTCTGCGTGCGCACGCTGGATCTCCTCCAGGTCGCCCACGGTGGCCAACCTGGCCCTGAACTCGCACCAGGTGACGTGCAGGATCTGGTTGGCGATGTAGCCCTGGATGACCTTCACGAAATGCTGCATCTCGTGCTTGAACAGCTGCAGCTGACGGAACTGCACAGAGCCGGCCATGTGGCTCAGCAGGGCTGGCGGAGGGCAGAAGGCAGAGGGCAGAGGTGAGCGCAGCCTCCAGCCAGGGGTGCGGGGCGCCGGGCTCCAGCGGGGCCTCACCTGTGCGCTTGAGGTGGAAGCAGACGT...
benign
328,489
Considering the variant on chromosome 22, location 50220465, involving gene TUBGCP6 (tubulin gamma complex component 6), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Microcephaly_and_chorioretinopathy_1']
AAGGCAGAGGGCAGAGGTGAGCGCAGCCTCCAGCCAGGGGTGCGGGGCGCCGGGCTCCAGCGGGGCCTCACCTGTGCGCTTGAGGTGGAAGCAGACGTCCTTGAGCGCCCACATCATGAGCTTCAGCTGCAGCAGGAAGGAGAAGACGCCGCTGTACTTGCTCACGCAGCCCTCGGTGATGACAATGTTGAGAGGCCAGTCCACCTGCCAGGAGGCGTGGCTCAGCAGGCATCCCACAGGCAGGCAGGCCCCTGTCCCATCCCCCGCGGCCAGGGCTGCTGCTGACCTTGTACCTGAGCTCCAGGCAGCTCAGCACATCC...
AAGGCAGAGGGCAGAGGTGAGCGCAGCCTCCAGCCAGGGGTGCGGGGCGCCGGGCTCCAGCGGGGCCTCACCTGTGCGCTTGAGGTGGAAGCAGACGTCCTTGAGCGCCCACATCATGAGCTTCAGCTGCAGCAGGAAGGAGAAGACGCCGCTGTACTTGCTCACGCAGCCCTCGGTGATGACAATGTTGAGAGGCCAGTCCACCTGCCAGGAGGCGTGGCTCAGCAGGCATCCCACAGGCAGGCAGGCCCCTGTCCCATCCCCCGCGGCCAGGGCTGCTGCTGACCTTGTACCTGAGCTCCAGGCAGCTCAGCACATCC...
pathogenic
328,494
The chromosome 22, position 50224176 genetic variant in gene TUBGCP6 (tubulin gamma complex component 6): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Microcephaly_and_chorioretinopathy_1']
TGGCCAAGCCGGAGTCAAGCACAGCCCTACCCCACACAAAGCCACAGCCCCTACCGCCCATGGCAGCCATGTGCACTGAACCAGACAAGGCTTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAG...
TGGCCAAGCCGGAGTCAAGCACAGCCCTACCCCACACAAAGCCACAGCCCCTACCGCCCATGGCAGCCATGTGCACTGAACCAGACAAGGCTTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAG...
pathogenic
328,538
Variant in TUBGCP6 (tubulin gamma complex component 6), chromosome 22, position 50224188—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic
AGTCAAGCACAGCCCTACCCCACACAAAGCCACAGCCCCTACCGCCCATGGCAGCCATGTGCACTGAACCAGACAAGGCTTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAGACATACCTGAAT...
AGTCAAGCACAGCCCTACCCCACACAAAGCCACAGCCCCTACCGCCCATGGCAGCCATGTGCACTGAACCAGACAAGGCTTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAGACATACCTGAAT...
pathogenic
328,539
Variant at chromosome position 50224267, chromosome 22, gene TUBGCP6 (tubulin gamma complex component 6): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
TTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAGACATACCTGAATGTGTTTCTCATCTTCTAAGAGAAAACGAAGCCGTGCACTCTCCAGTCGGTGCCTCTGGATTCTCCACAGTGCCTTCTGC...
TTGTGCTGGGCTCCAGTGGGACGCTGGGCCTGCAAAAAGTACTCCAAAACCACGAGCTCCTCACCACCTGTATCTGTGCAATTTGGTGGCACACGGGGAGAGAGAGTGCTCTGCCGCAAACGCGAAAGCCACCAGCCCTCTCCTAGAAGAGCATGTAGGTTTGTGTGCAGTCTCAGGGGGTTTCCAGACCCCCAAAGCCCAGGGGAAGAGCTGCCATCTGAAGCCGCAGACATACCTGAATGTGTTTCTCATCTTCTAAGAGAAAACGAAGCCGTGCACTCTCCAGTCGGTGCCTCTGGATTCTCCACAGTGCCTTCTGC...
benign
328,542
Located at chromosome 22 position 50226363, the variant affecting gene TUBGCP6 (tubulin gamma complex component 6)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Microcephaly_and_chorioretinopathy_1']
GGACAGGTCCTACCCACCTCCTGGTCCTTCACAAATTGTTCTTTCAGCCTCTGAAACTGCTCACGCTTCCGGGCATCCAAGGCCATCCGTTCTGACATCTGCCGGTCTACATTGGGACAGTAAGGGGCGCACTGTCACAAGGAGGCCCCAGCAAGGCCCCCCGGAACTGCAGAAGGGAGGACTTGGGGCCACTCACCACTCAGTGCACTCAGGACCCTGGATGCTGCTTCCCGGGCATGAGCGATTAATTCTTGTTTTGCAATTTCCATACGTAATTCCTGAGAAAGACAACTGGTAATCAAAGCATCCTGGCCGGGCGC...
GGACAGGTCCTACCCACCTCCTGGTCCTTCACAAATTGTTCTTTCAGCCTCTGAAACTGCTCACGCTTCCGGGCATCCAAGGCCATCCGTTCTGACATCTGCCGGTCTACATTGGGACAGTAAGGGGCGCACTGTCACAAGGAGGCCCCAGCAAGGCCCCCCGGAACTGCAGAAGGGAGGACTTGGGGCCACTCACCACTCAGTGCACTCAGGACCCTGGATGCTGCTTCCCGGGCATGAGCGATTAATTCTTGTTTTGCAATTTCCATACGTAATTCCTGAGAAAGACAACTGGTAATCAAAGCATCCTGGCCGGGCGC...
pathogenic
328,551
For chromosome 22, position 50227903, gene TUBGCP6 (tubulin gamma complex component 6): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic
GCACAGTCCTTCTCAATCTCCTTCAACTCCTCAAGGGAGAAAATCACCGAGATCCGGGGGACAGGGACGTCGGACCAACAGAGGTAATGCTGCCAAAGGGGATGCAAGCACAGCCACCAGCACTCAGCCCCAGCCTCATACTCAGCCCCAGGGAAGACCGGCCCCTCTCTTCCCCACACATGAGCCCCTCCTCACCCGGGGGCAGCAGAGCTTCAGCAGGTTAATGGTCTTTCCGCAGACGTATATGTCGTGGGCAATGTGCTTCAGAAACACGGGAACACAGTCCTCCACCTCTTTGGAGATGAGCACGTAGCCATGTG...
GCACAGTCCTTCTCAATCTCCTTCAACTCCTCAAGGGAGAAAATCACCGAGATCCGGGGGACAGGGACGTCGGACCAACAGAGGTAATGCTGCCAAAGGGGATGCAAGCACAGCCACCAGCACTCAGCCCCAGCCTCATACTCAGCCCCAGGGAAGACCGGCCCCTCTCTTCCCCACACATGAGCCCCTCCTCACCCGGGGGCAGCAGAGCTTCAGCAGGTTAATGGTCTTTCCGCAGACGTATATGTCGTGGGCAATGTGCTTCAGAAACACGGGAACACAGTCCTCCACCTCTTTGGAGATGAGCACGTAGCCATGTG...
pathogenic
328,561
A mutation at chromosome position 50447308 on chromosome 22 in gene SBF1 (SET binding factor 1): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
CTGACATTTTTCCGTTTGGGGGATGGGGGGAACCACTTCGCCTAACGCTCAAACACATCAACCCCAGGACTTCCTTTTGTGCCAGCTCCCCCTCCCAGAAGCCTGGGCCCCACCTTGTCCTCAGTGGCTGAGTGGGAGGGGCAGGTGGAGACCAGACCCCCACCCCGCCCCAGCGAGCTTGTCTTTCCACCACGGTTGGGGGTGGAGGGAACCCGCTCAGCTCCCCAGAGGCCGAGTCTCTGCCCCAGCTACACATTGAGTGCCTTGTTCTCGCCGCCTACCCTGTGCCTGGCATTTGTCCTCTCCCCCCACAGACGTGG...
CTGACATTTTTCCGTTTGGGGGATGGGGGGAACCACTTCGCCTAACGCTCAAACACATCAACCCCAGGACTTCCTTTTGTGCCAGCTCCCCCTCCCAGAAGCCTGGGCCCCACCTTGTCCTCAGTGGCTGAGTGGGAGGGGCAGGTGGAGACCAGACCCCCACCCCGCCCCAGCGAGCTTGTCTTTCCACCACGGTTGGGGGTGGAGGGAACCCGCTCAGCTCCCCAGAGGCCGAGTCTCTGCCCCAGCTACACATTGAGTGCCTTGTTCTCGCCGCCTACCCTGTGCCTGGCATTTGTCCTCTCCCCCCACAGACGTGG...
benign
328,608
Does the variant on chromosome 22 at location 50447464 affecting gene SBF1 (SET binding factor 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
CCCCCACCCCGCCCCAGCGAGCTTGTCTTTCCACCACGGTTGGGGGTGGAGGGAACCCGCTCAGCTCCCCAGAGGCCGAGTCTCTGCCCCAGCTACACATTGAGTGCCTTGTTCTCGCCGCCTACCCTGTGCCTGGCATTTGTCCTCTCCCCCCACAGACGTGGAACAGGGAGGGCAGGGTCCTTTCTCCCCTTACTCTGACCTGTGGGTTTTCCAGGTGCCAGGAACTTCGGTCAGGCGCCATCTGTCCGGCCTGAGGGAAGACCTGGCTGGTTTCAGTGGCTCAAGTGAGCCCACCCTCACATCTCGCCCAGGTGTCC...
CCCCCACCCCGCCCCAGCGAGCTTGTCTTTCCACCACGGTTGGGGGTGGAGGGAACCCGCTCAGCTCCCCAGAGGCCGAGTCTCTGCCCCAGCTACACATTGAGTGCCTTGTTCTCGCCGCCTACCCTGTGCCTGGCATTTGTCCTCTCCCCCCACAGACGTGGAACAGGGAGGGCAGGGTCCTTTCTCCCCTTACTCTGACCTGTGGGTTTTCCAGGTGCCAGGAACTTCGGTCAGGCGCCATCTGTCCGGCCTGAGGGAAGACCTGGCTGGTTTCAGTGGCTCAAGTGAGCCCACCCTCACATCTCGCCCAGGTGTCC...
benign
328,613
Variant chromosome 22, position 50459237, gene SBF1 (SET binding factor 1): benign or pathogenic? Disease(s)?
benign
GAGGGTTCCACCAAGCCCCCAGGGAGCCTGGAGACAGCAGGGGTCAGCCCCAAGTCCCTGATCGCAGGAAAGTGGGAAGAGCCATCCTGGTGTGGGCCTCTCTGCCAGGGCAGGGCAGGCCGCAGAGCACTCCGTGGCAGCAGAAGGGCTATGCGGTGGGGATCCCGGGCTCTCCTCTAACACTTCCTTTCTTCCCACTCAAACCAGCTTAGAGCAAGTCTGTCTCTGAGTCCCTCCCTCCACATCCTGGCCCTTTGTCCTCCACTCAGGGGGCCAGGGCTTGTGATGGGCACAGCTCAGAACGCTCCACACATGAGCAT...
GAGGGTTCCACCAAGCCCCCAGGGAGCCTGGAGACAGCAGGGGTCAGCCCCAAGTCCCTGATCGCAGGAAAGTGGGAAGAGCCATCCTGGTGTGGGCCTCTCTGCCAGGGCAGGGCAGGCCGCAGAGCACTCCGTGGCAGCAGAAGGGCTATGCGGTGGGGATCCCGGGCTCTCCTCTAACACTTCCTTTCTTCCCACTCAAACCAGCTTAGAGCAAGTCTGTCTCTGAGTCCCTCCCTCCACATCCTGGCCCTTTGTCCTCCACTCAGGGGGCCAGGGCTTGTGATGGGCACAGCTCAGAACGCTCCACACATGAGCAT...
benign
328,662
For chromosome 22, position 50462186, gene SBF1 (SET binding factor 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
CTGGGCTCCAGCTCCTCCGACACTGCACAGGCCGGGCACACGTGGTCATCACGGGGCCACTCCGCCTGCCCTGATCCTCCCTGGCCAATGTCAGCATCCAGAGACCACCCAGGACTCCACCCCCACCCCTCCACCTGAGATCTCGTCCTCCTGGTCCTCAGGGGGCGGCTGGCCCCGGTGCTCCCAGCTGGGGGGGTTGTACTTCTTGCGAGTGACATGCTGCCGCCCGATGGTCTTCTTGGCGTTCTTGACCAGGTTCCGGGACAGGGTTCTGAGGCCCACGAGAGTCAGCAAAGGTGAGAGGAGGAGGGACAAAGATG...
CTGGGCTCCAGCTCCTCCGACACTGCACAGGCCGGGCACACGTGGTCATCACGGGGCCACTCCGCCTGCCCTGATCCTCCCTGGCCAATGTCAGCATCCAGAGACCACCCAGGACTCCACCCCCACCCCTCCACCTGAGATCTCGTCCTCCTGGTCCTCAGGGGGCGGCTGGCCCCGGTGCTCCCAGCTGGGGGGGTTGTACTTCTTGCGAGTGACATGCTGCCGCCCGATGGTCTTCTTGGCGTTCTTGACCAGGTTCCGGGACAGGGTTCTGAGGCCCACGAGAGTCAGCAAAGGTGAGAGGAGGAGGGACAAAGATG...
benign
328,701
Variant at chromosome 22, position 50462445, gene SBF1 (SET binding factor 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Charcot-Marie-Tooth_disease_type_4']
CGGGACAGGGTTCTGAGGCCCACGAGAGTCAGCAAAGGTGAGAGGAGGAGGGACAAAGATGAGCACAGGGGCCTAGGAGGGTTGGAGCGGGAACACGGCTGAGGCCCAGCTGCCCTGCCTGGGACCCAGATCCATACCTGAGGGAAGGACCCTTGTCCTTGGTGACTCGCGGTGGCCGGCCAGGTGTGTGGGCAGAGCCCAAGGTGAACGCAAAGGTGGCCCTGATGTCCGGCGGGTACCGCAGCTTATGCAGCTGCTTACGGAAGAGCTCGGCGCTGTCAGACCCCACCTCCTCGTCAAAGGCCATTTTCAGCAGCTGT...
CGGGACAGGGTTCTGAGGCCCACGAGAGTCAGCAAAGGTGAGAGGAGGAGGGACAAAGATGAGCACAGGGGCCTAGGAGGGTTGGAGCGGGAACACGGCTGAGGCCCAGCTGCCCTGCCTGGGACCCAGATCCATACCTGAGGGAAGGACCCTTGTCCTTGGTGACTCGCGGTGGCCGGCCAGGTGTGTGGGCAGAGCCCAAGGTGAACGCAAAGGTGGCCCTGATGTCCGGCGGGTACCGCAGCTTATGCAGCTGCTTACGGAAGAGCTCGGCGCTGTCAGACCCCACCTCCTCGTCAAAGGCCATTTTCAGCAGCTGT...
pathogenic
328,706
The mutation impacting SBF1 (SET binding factor 1) on chromosome 22 at position 50464920: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
GGCAGAAGGCTGTGACCAGAGGCAGCAGAGCCGCCGCAATGCCATGCTCGTCCAGAGAAGTGCAGTCCTGCAGGTAGAGCGAGAGACCGTCAGGACCTCTCCCCTCCCAGGCAGCACTCACCTCCCACCATGCCCCCACCACCCCATAACCACCACAGACCAGCACCTGACACCCTTGGCTCCAGCTCCCCAAGGCTGCCTCAGAGGCTCAATATCAGGAGACCCCAGGCCCCAGCACCTGCCCCCAACAATGGTTCTCTCCACCCTGTTCCCTGCAGACCGAGGACCCCTGCCCACTGGCACAGGAGTCTCTTGCACCG...
GGCAGAAGGCTGTGACCAGAGGCAGCAGAGCCGCCGCAATGCCATGCTCGTCCAGAGAAGTGCAGTCCTGCAGGTAGAGCGAGAGACCGTCAGGACCTCTCCCCTCCCAGGCAGCACTCACCTCCCACCATGCCCCCACCACCCCATAACCACCACAGACCAGCACCTGACACCCTTGGCTCCAGCTCCCCAAGGCTGCCTCAGAGGCTCAATATCAGGAGACCCCAGGCCCCAGCACCTGCCCCCAACAATGGTTCTCTCCACCCTGTTCCCTGCAGACCGAGGACCCCTGCCCACTGGCACAGGAGTCTCTTGCACCG...
benign
328,735
Does the variant on chromosome 22 at location 50523655 affecting gene SCO2 have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic
AAGGTAATTGGGTGGAAGGTACCTCCACTCAGGTACCCCTGGCTGGGTTTCCTGGGGCATGAGGTGGGGGGGTGGGAGTGGGCTTTGCACCCTGATCCCCCAGCGGCTCTAAGACAGTCCCTGTTTGCCCCCAGGTAGGCCTTACTCTGTGCCCCCCTGTGTGGAGGAGGCTCTGGGACAGAAGCGCAAGAGGAAGGGCGCTGCCAAGCTGCAGGACTTCCACCAGTGGTACCTGGCTGCCTGTGAGTGGGTGTGGTGTGCACTCCGGACCACTGGGAGCTGGGGGCTGGGCCAGGGCCAGTGGAGGAGGATCAGCACCC...
AAGGTAATTGGGTGGAAGGTACCTCCACTCAGGTACCCCTGGCTGGGTTTCCTGGGGCATGAGGTGGGGGGGTGGGAGTGGGCTTTGCACCCTGATCCCCCAGCGGCTCTAAGACAGTCCCTGTTTGCCCCCAGGTAGGCCTTACTCTGTGCCCCCCTGTGTGGAGGAGGCTCTGGGACAGAAGCGCAAGAGGAAGGGCGCTGCCAAGCTGCAGGACTTCCACCAGTGGTACCTGGCTGCCTGTGAGTGGGTGTGGTGTGCACTCCGGACCACTGGGAGCTGGGGGCTGGGCCAGGGCCAGTGGAGGAGGATCAGCACCC...
pathogenic
328,792
Variant on chromosome 22, at position 50524009, affecting SCO2: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1', 'Myopia_6']
TGGTGCTGAGCATGTTCTTTCACAGATGCAGACCATGCCGACAGCAGGCGGCTTCGGCGAAAGGGTCCGTCCTTTGCAGGTGAGGCTGAAGTCCTCGGGGAAGACAGTTTTACTCTCCTTCCCCTACCTCTTCCCCCACCTGGTGTCACCCAAAGCCTTGGGTGGACTGGCACGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTA...
TGGTGCTGAGCATGTTCTTTCACAGATGCAGACCATGCCGACAGCAGGCGGCTTCGGCGAAAGGGTCCGTCCTTTGCAGGTGAGGCTGAAGTCCTCGGGGAAGACAGTTTTACTCTCCTTCCCCTACCTCTTCCCCCACCTGGTGTCACCCAAAGCCTTGGGTGGACTGGCACGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTA...
pathogenic
328,804
Gene SCO2 variant at chromosome 22, position 50524083—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1']
TGCAGGTGAGGCTGAAGTCCTCGGGGAAGACAGTTTTACTCTCCTTCCCCTACCTCTTCCCCCACCTGGTGTCACCCAAAGCCTTGGGTGGACTGGCACGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAG...
TGCAGGTGAGGCTGAAGTCCTCGGGGAAGACAGTTTTACTCTCCTTCCCCTACCTCTTCCCCCACCTGGTGTCACCCAAAGCCTTGGGTGGACTGGCACGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAG...
pathogenic
328,807
The mutation impacting SCO2 on chromosome 22 at position 50524181: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1']
CGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCAC...
CGGGGCCTGGGAAGGACGAGGGAGCCCTCACAAGGCCTTTGTCTGCAGACATGGAGGTCCTGTACTGGACACACGTGAAGGAGCAGTTGGAAACTCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCAC...
pathogenic
328,813
Variant at chromosome 22, position 50524275, gene SCO2: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1']
TCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGA...
TCTCCGGAAGCTGCAGAGGAGGGAGGCAAGTCCCAGCTGGTCAGCTGTGATCTAGGACCCCGTGGTGGCCCTGATGGGAGGTGACAGTGCCCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGA...
pathogenic
328,816
Mutation at chromosome 22, position 50524365, within SCO2: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1']
CCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGACCCCAGGGAAGCCGCTGACCTTGGTAGGTGGGCAGCGGGCTAGGAGTGCTGAGGGGCCACTGGAGCTGGGGGCAGGGGAGAGCGTGGCCC...
CCCTCACAGATGCTTTCTCTGGACAGGTGGCTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGACCCCAGGGAAGCCGCTGACCTTGGTAGGTGGGCAGCGGGCTAGGAGTGCTGAGGGGCCACTGGAGCTGGGGGCAGGGGAGAGCGTGGCCC...
pathogenic
328,818
Variant at chromosome 22, position 50524395, gene SCO2: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Cardioencephalomyopathy,_fatal_infantile,_due_to_cytochrome_c_oxidase_deficiency_1', 'Myopia_6', 'Primary_dilated_cardiomyopathy']
CTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGACCCCAGGGAAGCCGCTGACCTTGGTAGGTGGGCAGCGGGCTAGGAGTGCTGAGGGGCCACTGGAGCTGGGGGCAGGGGAGAGCGTGGCCCCTTAGCTGCCCAGCTCACAGCTACCCCTTC...
CTGAGCAGTGGCTGCGGCCTGCAGAGGAGGACCACCTGGAGGATTCCCTGGAAGACCTGGGGGCAGCAGGTGGGTGCCTGCCAGGGGGTGGGGTGGGGCTTGGCACCTGCCGACTAGCTGCCTGCGTGCTGTTCACTCTCCCACCTCCCAGCAGATGACTTTCTAGAGCCTGAGGAGTACATGGAGCCCGAGGGAGCAGACCCCAGGGAAGCCGCTGACCTTGGTAGGTGGGCAGCGGGCTAGGAGTGCTGAGGGGCCACTGGAGCTGGGGGCAGGGGAGAGCGTGGCCCCTTAGCTGCCCAGCTCACAGCTACCCCTTC...
pathogenic
328,819
The mutation impacting TYMP on chromosome 22 at position 50525589: benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
CTGGTACAGATCACACACACACACAGATTAAACGCAGCCCGTTTAATGATGGGGCCCAGACTGCAGTGGCTCAAGACAGGACACTGCGGAAAGCCGCCATGTGCCGCCGCACACTGTCTGAGATCTGCTCAGCCGATCTGCTCCGGCCGTAGTAATCCGTGAAGAGGCCGTCAGGGTTGAGCAGGTAGATGGCAATGGAGTGGTCCACGATGTAGTCCTGGTCCTCATCCTTGGGGCCTGCATTGTAGTACACGCGGTAACTGTGACTAGCCTGGGCAACCTGTTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGG...
CTGGTACAGATCACACACACACACAGATTAAACGCAGCCCGTTTAATGATGGGGCCCAGACTGCAGTGGCTCAAGACAGGACACTGCGGAAAGCCGCCATGTGCCGCCGCACACTGTCTGAGATCTGCTCAGCCGATCTGCTCCGGCCGTAGTAATCCGTGAAGAGGCCGTCAGGGTTGAGCAGGTAGATGGCAATGGAGTGGTCCACGATGTAGTCCTGGTCCTCATCCTTGGGGCCTGCATTGTAGTACACGCGGTAACTGTGACTAGCCTGGGCAACCTGTTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGG...
benign
328,822
Is the genetic mutation found on chromosome 22 at position 50525802, within the gene TYMP, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
AGTCCTGGTCCTCATCCTTGGGGCCTGCATTGTAGTACACGCGGTAACTGTGACTAGCCTGGGCAACCTGTTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGGAAGTCCTGGACGTAGCGGGCCATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGA...
AGTCCTGGTCCTCATCCTTGGGGCCTGCATTGTAGTACACGCGGTAACTGTGACTAGCCTGGGCAACCTGTTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGGAAGTCCTGGACGTAGCGGGCCATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGA...
pathogenic
328,824
A genetic alteration at chromosome 22, position 50525872, in gene TYMP—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
TTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGGAAGTCCTGGACGTAGCGGGCCATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTC...
TTTGGTGGAGCCGGTCAGACCCAACAGTCTTGGGTGGAAGTCCTGGACGTAGCGGGCCATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTC...
pathogenic
328,830
Regarding the variant at chromosome 22 and position 50525929, affecting gene TYMP: benign or pathogenic? If pathogenic, what are the associated illness(es)?
benign
CATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTCGCTTTTGCTGCTGCAGCCTCTCCTTCTCAGCCCTCAGGGCCAGCCAGGCCCCACCGA...
CATGGCTTCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAAGACAGGCTGCACTGGAGGCAAACCAGGCTCTGCTTCCAGCTGCCGCACCACCTGCACCAGCTTCTCCAGCTCGTCTGGGCAGATGTCAGGGCAGTGAGTGAAGCCAAAGTACATCAGCACCCACTGGCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTCGCTTTTGCTGCTGCAGCCTCTCCTTCTCAGCCCTCAGGGCCAGCCAGGCCCCACCGA...
benign
328,831
Is chromosome 22, position 50526097, gene TYMP variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
GCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTCGCTTTTGCTGCTGCAGCCTCTCCTTCTCAGCCCTCAGGGCCAGCCAGGCCCCACCGAGTCCAGCCCCGAACAGGCCTGTGATCAGCAGCCGGGTTCGAAGCCCAGGGCCCTGGGGCTGGCCCTGCCCACCTGTCTCTGCAGGGCCCTGCCTTGACAAAAGCCAGGACCTCAGATGCAGGGCCTGGCCTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAG...
GCCCCGGAAGTCAGCCTTGCAGCGAGCCCGGCCTCTGTGATCCAGCAGGTGGAAGTCGCCCTGGCCCACAGCTGCCTGGCGCAGGGCTTCTGTTCGCTTTTGCTGCTGCAGCCTCTCCTTCTCAGCCCTCAGGGCCAGCCAGGCCCCACCGAGTCCAGCCCCGAACAGGCCTGTGATCAGCAGCCGGGTTCGAAGCCCAGGGCCCTGGGGCTGGCCCTGCCCACCTGTCTCTGCAGGGCCCTGCCTTGACAAAAGCCAGGACCTCAGATGCAGGGCCTGGCCTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAG...
pathogenic
328,837
A mutation at chromosome position 50526251 on chromosome 22 in gene TYMP: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['TYMP-related_disorder']
CCAGCCCCGAACAGGCCTGTGATCAGCAGCCGGGTTCGAAGCCCAGGGCCCTGGGGCTGGCCCTGCCCACCTGTCTCTGCAGGGCCCTGCCTTGACAAAAGCCAGGACCTCAGATGCAGGGCCTGGCCTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAGAGAGCCTGTGCCAAGCTGTGGGGCTCCGAGTCAGCAGCAGCATGGATCTGATGCTCCTGGAAACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACC...
CCAGCCCCGAACAGGCCTGTGATCAGCAGCCGGGTTCGAAGCCCAGGGCCCTGGGGCTGGCCCTGCCCACCTGTCTCTGCAGGGCCCTGCCTTGACAAAAGCCAGGACCTCAGATGCAGGGCCTGGCCTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAGAGAGCCTGTGCCAAGCTGTGGGGCTCCGAGTCAGCAGCAGCATGGATCTGATGCTCCTGGAAACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACC...
pathogenic
328,845
Variant chromosome 22, position 50526378, gene TYMP: benign or pathogenic? Disease(s)?
pathogenic
CTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAGAGAGCCTGTGCCAAGCTGTGGGGCTCCGAGTCAGCAGCAGCATGGATCTGATGCTCCTGGAAACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACCCAGCCCACGTTCAGGCTTAACAGGCATTTGCAGCTGCTCACCTGAGCTCAGAACTCCACCTCCACCAAACATCCACACCTGGGCAACCACACCTGTCACTCCTGTCCTCTACCTGGGATCACCAGCC...
CTCCCAGGGTCCCAGGGAGGACCCGAGGCTTGAGCTGAGAGAGCCTGTGCCAAGCTGTGGGGCTCCGAGTCAGCAGCAGCATGGATCTGATGCTCCTGGAAACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACCCAGCCCACGTTCAGGCTTAACAGGCATTTGCAGCTGCTCACCTGAGCTCAGAACTCCACCTCCACCAAACATCCACACCTGGGCAACCACACCTGTCACTCCTGTCCTCTACCTGGGATCACCAGCC...
pathogenic
328,851
Is chromosome 22, position 50526478, gene TYMP variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
AACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACCCAGCCCACGTTCAGGCTTAACAGGCATTTGCAGCTGCTCACCTGAGCTCAGAACTCCACCTCCACCAAACATCCACACCTGGGCAACCACACCTGTCACTCCTGTCCTCTACCTGGGATCACCAGCCTGTCACCGCACCCTGCCCTGCACCTGCACCTCAGCAAGGTGAACCTCTTGCTGACGGAAAGCATTCCAAGTGCATGCCTTGCCTGAACTAACCACGTTAT...
AACAAGCACAGGCGTCAGGAGCCAGAAGGGAAGGCCCAGGACAGTGCCTGGGCTGCCCCTGCGACTTGAGACCAGCCACCCATCTGAAGGACCCAGCCCACGTTCAGGCTTAACAGGCATTTGCAGCTGCTCACCTGAGCTCAGAACTCCACCTCCACCAAACATCCACACCTGGGCAACCACACCTGTCACTCCTGTCCTCTACCTGGGATCACCAGCCTGTCACCGCACCCTGCCCTGCACCTGCACCTCAGCAAGGTGAACCTCTTGCTGACGGAAAGCATTCCAAGTGCATGCCTTGCCTGAACTAACCACGTTAT...
benign
328,855
Evaluate the clinical significance of the mutation at chromosome 22, position 50526702 in gene TYMP (thymidine phosphorylase): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
ACCGCACCCTGCCCTGCACCTGCACCTCAGCAAGGTGAACCTCTTGCTGACGGAAAGCATTCCAAGTGCATGCCTTGCCTGAACTAACCACGTTATCTATTTGCAATAAACCCATTTCTTAAAAGGAGGTGGGTAACTCTCTGGCTTGCAATCCCCGAGAGCAACCGATTCCTCCAACACTTTCCTGTTACCTCCAGCCACTTCAACCAACCGCGGCCTTCCTCCACACTCCCAGCAGAAAACCTGCACGACCTACCCCCGGAGCTCAGACTCTGCCCGCCGGCTGTGTTTAACCTCTCCTGGCAGAGACGCACGACACT...
ACCGCACCCTGCCCTGCACCTGCACCTCAGCAAGGTGAACCTCTTGCTGACGGAAAGCATTCCAAGTGCATGCCTTGCCTGAACTAACCACGTTATCTATTTGCAATAAACCCATTTCTTAAAAGGAGGTGGGTAACTCTCTGGCTTGCAATCCCCGAGAGCAACCGATTCCTCCAACACTTTCCTGTTACCTCCAGCCACTTCAACCAACCGCGGCCTTCCTCCACACTCCCAGCAGAAAACCTGCACGACCTACCCCCGGAGCTCAGACTCTGCCCGCCGGCTGTGTTTAACCTCTCCTGGCAGAGACGCACGACACT...
pathogenic
328,862
The mutation impacting TYMP (thymidine phosphorylase) on chromosome 22 at position 50527200: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
GCACCCTCCCGAGGACTCACTGCACCCCCGCCCGGGCGGTTCTGGGTTTGTGCCCTCCCCAGCAAGGCCAGCGCCCTCGTGGCCAGAAAGGTTCCAGGACCACTCGAAGCGCCGCGCGAGCGCGTTATAACTGTGCTTGGCCGCGAGAACACCGGTGCCTGCTGGGAGCCTCCCACGGGCGCCCCAGCCTCGCTCCGGCCTCCAGCGCGCCCTGGGGTGTGCCCCGCCAGCCCCGCGCAGTAGCCGGAGCTGGGAAACTACCCCGGAGTCCAGCGAGTCCTCAGGGCTACCTCCTCCCCTCCCAGCCCCGGCGTCCGCAC...
GCACCCTCCCGAGGACTCACTGCACCCCCGCCCGGGCGGTTCTGGGTTTGTGCCCTCCCCAGCAAGGCCAGCGCCCTCGTGGCCAGAAAGGTTCCAGGACCACTCGAAGCGCCGCGCGAGCGCGTTATAACTGTGCTTGGCCGCGAGAACACCGGTGCCTGCTGGGAGCCTCCCACGGGCGCCCCAGCCTCGCTCCGGCCTCCAGCGCGCCCTGGGGTGTGCCCCGCCAGCCCCGCGCAGTAGCCGGAGCTGGGAAACTACCCCGGAGTCCAGCGAGTCCTCAGGGCTACCTCCTCCCCTCCCAGCCCCGGCGTCCGCAC...
pathogenic
328,867
Chromosome 22, position 50529278, gene TYMP: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic
CGTCCACCACCAGAGCGGACAGCCCCTCCACGAGTTTCTTACTGAGAATGGAGGCTTTGGGGGAGGCAGAGGAGGTTGGAGACAATGGAGAACCTGGAGCTTCTTGGGAGAGTTCGGGGATGCCGACTTTGGGGTCAGGGGCCCTGAGCATTGAGGGTCAAGTCCCTTATTATGGGGGTGGCAGCACCTGGTGGGTTGAGTATCAGGCCACCCCACATGGTGGTGGTCAGGCATCTTGTGATGGGGGTAGGGGGGCACACGGTCAGGTGACGGGTAACTCCTAACGAGAGGCCCTTGACTTGAGTTTGGAGGTCAGGAGC...
CGTCCACCACCAGAGCGGACAGCCCCTCCACGAGTTTCTTACTGAGAATGGAGGCTTTGGGGGAGGCAGAGGAGGTTGGAGACAATGGAGAACCTGGAGCTTCTTGGGAGAGTTCGGGGATGCCGACTTTGGGGTCAGGGGCCCTGAGCATTGAGGGTCAAGTCCCTTATTATGGGGGTGGCAGCACCTGGTGGGTTGAGTATCAGGCCACCCCACATGGTGGTGGTCAGGCATCTTGTGATGGGGGTAGGGGGGCACACGGTCAGGTGACGGGTAACTCCTAACGAGAGGCCCTTGACTTGAGTTTGGAGGTCAGGAGC...
pathogenic
328,893
Classify the chromosome 22 variant at position 50529689 affecting gene TYMP (thymidine phosphorylase) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
AGGATTCCGTCCGCAGGAACCAGCTGCTCACTCTGACCCACGATACAGCAGCCCGCCTGGTCCAGCAGCACTTGCATCTGGTCAGACATCCCCTGTTCTCAGTGACTTATGGTAAATGACTTAGCAGCTTTTTTTTTTTTTTTTTTTTTTTCTGTGAAGAGTCTTCCTCTGTTGCCCAGGCTGGAGTGCAGTTGGCACAATTTCGGCTCATTGTGACCTCTGCCTCCTGGGCTTAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTGGGACTACAGGTGCGCACCACCACACGCGGCTTTTTTTTTTCTTCTTTTTTTT...
AGGATTCCGTCCGCAGGAACCAGCTGCTCACTCTGACCCACGATACAGCAGCCCGCCTGGTCCAGCAGCACTTGCATCTGGTCAGACATCCCCTGTTCTCAGTGACTTATGGTAAATGACTTAGCAGCTTTTTTTTTTTTTTTTTTTTTTTCTGTGAAGAGTCTTCCTCTGTTGCCCAGGCTGGAGTGCAGTTGGCACAATTTCGGCTCATTGTGACCTCTGCCTCCTGGGCTTAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTGGGACTACAGGTGCGCACCACCACACGCGGCTTTTTTTTTTCTTCTTTTTTTT...
pathogenic
328,904
Evaluate if the mutation on chromosome 22 at position 50529698 in TYMP (thymidine phosphorylase) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Mitochondrial_DNA_depletion_syndrome_1']
TCCGCAGGAACCAGCTGCTCACTCTGACCCACGATACAGCAGCCCGCCTGGTCCAGCAGCACTTGCATCTGGTCAGACATCCCCTGTTCTCAGTGACTTATGGTAAATGACTTAGCAGCTTTTTTTTTTTTTTTTTTTTTTTCTGTGAAGAGTCTTCCTCTGTTGCCCAGGCTGGAGTGCAGTTGGCACAATTTCGGCTCATTGTGACCTCTGCCTCCTGGGCTTAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTGGGACTACAGGTGCGCACCACCACACGCGGCTTTTTTTTTTCTTCTTTTTTTTGTAGAGATC...
TCCGCAGGAACCAGCTGCTCACTCTGACCCACGATACAGCAGCCCGCCTGGTCCAGCAGCACTTGCATCTGGTCAGACATCCCCTGTTCTCAGTGACTTATGGTAAATGACTTAGCAGCTTTTTTTTTTTTTTTTTTTTTTTCTGTGAAGAGTCTTCCTCTGTTGCCCAGGCTGGAGTGCAGTTGGCACAATTTCGGCTCATTGTGACCTCTGCCTCCTGGGCTTAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTGGGACTACAGGTGCGCACCACCACACGCGGCTTTTTTTTTTCTTCTTTTTTTTGTAGAGATC...
pathogenic
328,905
The mutation impacting ARSA (arylsulfatase A) on chromosome 22 at position 50625182: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Metachromatic_leukodystrophy']
GGCCAACACTGAGGGAGCACCTGGCGTGTGACTGGCCACCTGGGCATGCACGTGGGCCTGACGTCAGTGTGCCATGCTGCACAGACACGGGCAGGTGCTCAGACAGTCCCTCCCTGCAGAGGAGGCCAACAATGGAGGCAGAGCGTTGCCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTA...
GGCCAACACTGAGGGAGCACCTGGCGTGTGACTGGCCACCTGGGCATGCACGTGGGCCTGACGTCAGTGTGCCATGCTGCACAGACACGGGCAGGTGCTCAGACAGTCCCTCCCTGCAGAGGAGGCCAACAATGGAGGCAGAGCGTTGCCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTA...
pathogenic
328,960
Clinical classification of chromosome 22, position 50625182, gene ARSA (arylsulfatase A): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Metachromatic_leukodystrophy']
GGCCAACACTGAGGGAGCACCTGGCGTGTGACTGGCCACCTGGGCATGCACGTGGGCCTGACGTCAGTGTGCCATGCTGCACAGACACGGGCAGGTGCTCAGACAGTCCCTCCCTGCAGAGGAGGCCAACAATGGAGGCAGAGCGTTGCCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTA...
GGCCAACACTGAGGGAGCACCTGGCGTGTGACTGGCCACCTGGGCATGCACGTGGGCCTGACGTCAGTGTGCCATGCTGCACAGACACGGGCAGGTGCTCAGACAGTCCCTCCCTGCAGAGGAGGCCAACAATGGAGGCAGAGCGTTGCCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTA...
pathogenic
328,961
Does the variant on chromosome 22 at location 50625330 affecting gene ARSA (arylsulfatase A) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Metachromatic_leukodystrophy']
CCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATT...
CCGTTGAAGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATT...
pathogenic
328,965
Variant at chromosome 22, position 50625337, gene ARSA (arylsulfatase A): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Metachromatic_leukodystrophy']
AGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAA...
AGGGAACAGCCAGGCCACCCCCTAAGACTGGGGGGAAGGGGGTGTGGGTGGAGGCCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAA...
pathogenic
328,966
Regarding the variant found on chromosome 22 at position 50625391 in gene ARSA (arylsulfatase A): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Metachromatic_leukodystrophy']
CCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGG...
CCTCAAGGGCAAACTGGGTCACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGG...
pathogenic
328,968
The genetic variant at chromosome 22, position 50625410, affecting gene ARSA (arylsulfatase A): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Metachromatic_leukodystrophy']
CACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACC...
CACTGTAAGGGGTTTGGATTTTCTTCTGAGAAGCCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACC...
pathogenic
328,971
Determine whether the variant at chromosome 22, position 50625443, in gene ARSA (arylsulfatase A) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Metachromatic_leukodystrophy']
CCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAAC...
CCTGCGAAATTTTGAGCAGGAATAGATGCTCAAGCCCAGCCTGATGTTTTATTTGTTTATTTGCAGACAGGGTCTCACTCTGTCCCCGAGGCTGGAGTGCAGTGGTACAATTATAGCTCACTACAGCCTCGACCTAGTGGGCTGAAGTGATTCTCCCACCTCAACCTCCCAAATTGCTAGGACAAATGCTACCACGCCTGGCTAATTAAAACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAAC...
pathogenic
328,973
The genetic variant at chromosome 22, position 50625652, affecting gene ARSA (arylsulfatase A): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Metachromatic_leukodystrophy']
AACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAATCTTGTCTCTATTAAATAAAAAAAAATTAGCTGGGCATGGCAGCACACACCTGTAGTTCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCCCTGGAACCCGGGAGGCGGAGGTTGCAGTGAGCGGAGATGGTACCACTGCACTCTAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAA...
AACAAATATTGTTGGCCAGGTGTGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAATCTTGTCTCTATTAAATAAAAAAAAATTAGCTGGGCATGGCAGCACACACCTGTAGTTCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCCCTGGAACCCGGGAGGCGGAGGTTGCAGTGAGCGGAGATGGTACCACTGCACTCTAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAA...
pathogenic
328,983
Is the genetic change at chromosome 22, position 50625934, within gene ARSA (arylsulfatase A) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Metachromatic_leukodystrophy']
GAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAACAAATCTTTAGAGCTGGGGTCTCACTATGTTGCCCAGGCTGGTCTGAATTCCTGGCCTCAGGCATCCTCTCACCTCAGCCTCCCAAAGCACTGGGAATACAGGAGTGAATCGCCGTGTGCAGCCTAACAGATTTTTTGTTTTTTGAGACAGAGTTTTTCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAACCACCGCCTCCCAGGTTCAAGTGATTCTCCAGCCTCAGACTCCCAAGTAGCTG...
GAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAACAAATCTTTAGAGCTGGGGTCTCACTATGTTGCCCAGGCTGGTCTGAATTCCTGGCCTCAGGCATCCTCTCACCTCAGCCTCCCAAAGCACTGGGAATACAGGAGTGAATCGCCGTGTGCAGCCTAACAGATTTTTTGTTTTTTGAGACAGAGTTTTTCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAACCACCGCCTCCCAGGTTCAAGTGATTCTCCAGCCTCAGACTCCCAAGTAGCTG...
pathogenic
328,993