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Extract chemical and disease entities from the following text. | Naloxone reverses the antihypertensive effect of clonidine. In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldo... | Chemical/Disease Entities: Naloxone (Chemical), clonidine (Chemical), hypertensive (Disease), clonidine (Chemical), nalozone (Chemical), hypotensive (Disease), alpha-methyldopa (Chemical), naloxone (Chemical), Naloxone (Chemical), hypertensive (Disease), clonidine (Chemical), [3H]-naloxone (Chemical), naloxone (Chemica... |
Extract chemical and disease entities from the following text. | Lidocaine-induced cardiac asystole. Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the deve... | Chemical/Disease Entities: Lidocaine (Chemical), cardiac asystole (Disease), lidocaine (Chemical), depression (Disease), bradyarrhythmias (Disease), lidocaine (Chemical) |
Extract chemical and disease entities from the following text. | Suxamethonium infusion rate and observed fasciculations. A dose-response study. Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 ... | Chemical/Disease Entities: Suxamethonium (Chemical), fasciculations (Disease), Suxamethonium chloride (Chemical), Sch (Chemical), tetanic (Disease), Sch (Chemical), Fasciculations (Disease), fasciculation (Disease), fasciculation (Disease), twitch (Disease), tetanus (Disease), Fasciculations (Disease), fasciculation (D... |
Extract chemical and disease entities from the following text. | Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overd... | Chemical/Disease Entities: Galanthamine hydrobromide (Chemical), scopolamine (Chemical), Hyoscine (Chemical), Galanthamine hydrobromide (Chemical), scopolamine (Chemical), hyoscine (Chemical), overdosage (Disease), physostigmine (Chemical), scopolamine (Chemical) |
Extract chemical and disease entities from the following text. | Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats. Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failu... | Chemical/Disease Entities: lithium (Chemical), chronic renal failure (Disease), lithium (Chemical), nephropathy (Disease), renal failure (Disease), lithium (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), Li (Chemical), Lithium (Chemical... |
Extract chemical and disease entities from the following text. | Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn's disease, a pilot stu... | Chemical/Disease Entities: Crohn's disease (Disease), fusidic acid (Chemical), cyclosporin (Chemical), cyclosporin (Chemical), Crohn's disease (Disease), fusidic acid (Chemical), Crohn's disease (Disease), Fusidic acid (Chemical), fusidic acid (Chemical), nausea (Disease), fusidic acid (Chemical), Crohn's disease (Dise... |
Extract chemical and disease entities from the following text. | Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial inju... | Chemical/Disease Entities: myocardial injury (Disease), cocaine (Chemical), cocaine (Chemical), schizophrenic (Disease), cocaine (Chemical), myocardial injury (Disease), myocardial infarction (Disease), ischemia (Disease), bundle branch block (Disease) |
Extract chemical and disease entities from the following text. | Sulpiride-induced tardive dystonia. Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man ... | Chemical/Disease Entities: Sulpiride (Chemical), tardive dystonia (Disease), Sulpiride (Chemical), antidepressant (Chemical), sulpiride (Chemical), tardive dyskinesia (Disease), parkinsonism (Disease), dystonia (Disease), sulpiride (Chemical), sulpiride (Chemical), tardive dystonia (Disease) |
Extract chemical and disease entities from the following text. | Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine. During an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual... | Chemical/Disease Entities: desferrioxamine (Chemical), desferrioxamine (Chemical), audiovisual toxicity (Disease), Visual toxicity (Disease), dyschromatopsy (Disease), a loss of visual acuity (Disease), pigmentary retinal deposits (Disease), Auditory toxicity (Disease), neurosensorial hearing loss (Disease), Desferriox... |
Extract chemical and disease entities from the following text. | Myasthenia gravis presenting as weakness after magnesium administration. We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The... | Chemical/Disease Entities: Myasthenia gravis (Disease), magnesium (Chemical), neuromuscular disease (Disease), quadriplegic (Disease), magnesium (Chemical), preeclampsia (Disease), magnesium (Chemical), magnesium (Chemical), postsynaptic neuromuscular blockade (Disease), acetylcholine (Chemical), paralysis (Disease), m... |
Extract chemical and disease entities from the following text. | Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in or... | Chemical/Disease Entities: Chloroacetaldehyde (Chemical), cyclophosphamide (Chemical), ifosfamide (Chemical), chloroacetaldehyde (Chemical), CAA (Chemical), CAA (Chemical), CAA (Chemical), bladder damage (Disease), CAA (Chemical), mesna (Chemical) |
Extract chemical and disease entities from the following text. | Source of pain and primitive dysfunction in migraine: an identical site? Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10... | Chemical/Disease Entities: pain (Disease), migraine (Disease), migraine (Disease), nitroglycerin (Chemical), migraine (Disease), nitroglycerin (Chemical), migraine (Disease), nitroglycerin (Chemical), migraine (Disease), migraine (Disease), nitroglycerin (Chemical), pain (Disease), migraine (Disease), migraine (Disease... |
Extract chemical and disease entities from the following text. | Clotiazepam-induced acute hepatitis. We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benzod... | Chemical/Disease Entities: Clotiazepam (Chemical), hepatitis (Disease), hepatitis (Disease), extensive hepatocellular necrosis (Disease), clotiazepam (Chemical), thienodiazepine (Chemical), Clotiazepam (Chemical), benzodiazepines (Chemical), clotiazepam (Chemical), hepatitis (Disease), clotiazepam (Chemical), hepatitis... |
Extract chemical and disease entities from the following text. | Arterial hypertension as a complication of prolonged ketoconazole treatment. Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet cont... | Chemical/Disease Entities: hypertension (Disease), ketoconazole (Chemical), Cushing's syndrome (Disease), ketoconazole (Chemical), hypertension (Disease), cortisol (Chemical), ketoconazole (Chemical), hypertension (Disease), deoxycorticosterone (Chemical), 11-deoxycortisol (Chemical), deoxycorticosterone (Chemical), 11... |
Extract chemical and disease entities from the following text. | Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal in... | Chemical/Disease Entities: angiotensin (Chemical), Captopril (Chemical), intravascular coagulation (Disease), intravascular coagulation (Disease), tranexamic acid (Chemical), AMCA (Chemical), trauma (Disease), sepsis (Disease), Captopril (Chemical), angiotensin (Chemical), Captopril (Chemical), Renal damage (Disease), ... |
Extract chemical and disease entities from the following text. | A randomized comparison of labetalol and nitroprusside for induced hypotension. In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic prot... | Chemical/Disease Entities: labetalol (Chemical), nitroprusside (Chemical), hypotension (Disease), labetalol (Chemical), hypotension (Disease), nitroprusside (Chemical), hypotension (Disease), reductions in mean arterial blood pressure (Disease), increase in heart rate and cardiac output (Disease), hypertension (Disease... |
Extract chemical and disease entities from the following text. | Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed ... | Chemical/Disease Entities: carbamazepine (Chemical), toxicity (Disease), folate (Chemical), Folate (Chemical), Carbamazepine (Chemical), CBZ (Chemical), CBZ (Chemical), folate (Chemical), propylene glycol (Chemical), seizures (Disease), weight gain (Disease), Seizures (Disease), hexafluorodiethyl ether (Chemical), HFDE... |
Extract chemical and disease entities from the following text. | Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriureti... | Chemical/Disease Entities: sodium (Chemical), norepinephrine (Chemical), epinephrine (Chemical), tachycardia (Disease), norepinephrine (Chemical), hypotension (Disease), hydralazine (Chemical), nitroglycerin (Chemical), epinephrine (Chemical) |
Extract chemical and disease entities from the following text. | Death from chemotherapy in gestational trophoblastic disease. Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was... | Chemical/Disease Entities: Death (Disease), gestational trophoblastic disease (Disease), choriocarcinoma (Disease), Etoposide (Chemical), Methotrexate (Chemical), Cyclophosphamide (Chemical), Actomycin-D (Chemical), Cisplatin (Chemical), Methotrexate (Chemical), Etoposide (Chemical), Cyclophosphamide (Chemical), pulmon... |
Extract chemical and disease entities from the following text. | Sexual dysfunction among patients with arthritis. The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made usin... | Chemical/Disease Entities: Sexual dysfunction (Disease), arthritis (Disease), arthritis (Disease), sexual dysfunction (Disease), rheumatoid arthritis (Disease), osteoarthritis (Disease), spondyloarthropathy (Disease), depressed mood (Disease), Sexual dysfunctions (Disease), Impotence (Disease), methotrexate (Chemical),... |
Extract chemical and disease entities from the following text. | Does paracetamol cause urothelial cancer or renal papillary necrosis? The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The r... | Chemical/Disease Entities: paracetamol (Chemical), urothelial cancer (Disease), renal papillary necrosis (Disease), renal papillary necrosis (Disease), phenacetin (Chemical), paracetamol (Chemical), renal papillary necrosis (Disease), phenacetin (Chemical), ureteric cancer (Disease), paracetamol (Chemical), renal papil... |
Extract chemical and disease entities from the following text. | Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increa... | Chemical/Disease Entities: Dapsone (Chemical), hemolytic anemia (Disease), leprosy (Disease), hemolytic anemia (Disease), dapsone (Chemical), hemolysis (Disease), glutathione (Chemical), GSH (Chemical), GSH (Chemical), pentose phosphate (Chemical), dapsone (Chemical), dapsone (Chemical), GSH (Chemical), GSH (Chemical),... |
Extract chemical and disease entities from the following text. | Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular functio... | Chemical/Disease Entities: metoprolol (Chemical), propafenone (Chemical), diltiazem (Chemical), sparteine (Chemical), coronary artery disease (Disease), shock (Disease), AV block (Disease), hypotension (Disease), impairment of ventricular function (Disease), metoprolol (Chemical), diltiazem (Chemical), metoprolol (Chem... |
Extract chemical and disease entities from the following text. | Triazolam-induced brief episodes of secondary mania in a depressed patient. Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The pos... | Chemical/Disease Entities: Triazolam (Chemical), mania (Disease), depressed (Disease), triazolam (Chemical), mania (Disease), depressed (Disease), organic mental disorder (Disease), delirium (Disease), Manic (Disease), triazolam (Chemical), triazolo (Chemical) |
Extract chemical and disease entities from the following text. | On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic... | Chemical/Disease Entities: muscular rigidity (Disease), morphine (Chemical), muscular rigidity (Disease), morphine (Chemical), morphine (Chemical), rigidity (Disease), morphine (Chemical), rigidity (Disease), morphine (Chemical), akinetic (Disease), rigidity (Disease), akinetic (Disease), hyperkinetic (Disease), rigidi... |
Extract chemical and disease entities from the following text. | Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-o... | Chemical/Disease Entities: pentazocine (Chemical), fibrous myopathy (Disease), Fibrous myopathy (Disease), pentazocine (Chemical), compression neuropathy (Disease), pentazocine (Chemical), myopathy (Disease), pentazocine (Chemical), fibrous myopathy (Disease), fibrous myopathy (Disease) |
Extract chemical and disease entities from the following text. | Recurrent reversible acute renal failure from amphotericin. A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days sugg... | Chemical/Disease Entities: acute renal failure (Disease), amphotericin (Chemical), cirrhosis (Disease), sporotrichosis (Disease), acute renal failure (Disease), amphotericin B (Chemical), renal failure (Disease), renal dysfunction (Disease), amphotericin (Chemical), acute renal failure (Disease) |
Extract chemical and disease entities from the following text. | Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumoniti... | Chemical/Disease Entities: neuropathy (Disease), amiodarone (Chemical), sinuatrial disease (Disease), amiodarone (Chemical), supraventricular tachyarrhythmias (Disease), pneumonitis (Disease), proximal motor neuropathy (Disease), amiodarone (Chemical), prednisolone (Chemical), amiodarone (Chemical), pneumonitis (Diseas... |
Extract chemical and disease entities from the following text. | Indomethacin-induced renal insufficiency: recurrence on rechallenge. We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single ... | Chemical/Disease Entities: Indomethacin (Chemical), renal insufficiency (Disease), renal failure (Disease), hyperkalemia (Disease), cirrhosis (Disease), ascites (Disease), cor pulmonale (Disease), indomethacin (Chemical), indomethacin (Chemical), oliguria (Disease), prostaglandins (Chemical), acute renal failure (Disea... |
Extract chemical and disease entities from the following text. | Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers. Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chr... | Chemical/Disease Entities: flunitrazepam (Chemical), Flunitrazepam (Chemical), Dizziness (Disease), pain (Disease), flunitrazepam (Chemical) |
Extract chemical and disease entities from the following text. | Changes in heart size during long-term timolol treatment after myocardial infarction. The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-trea... | Chemical/Disease Entities: timolol (Chemical), myocardial infarction (Disease), timolol (Chemical), myocardial infarction (Disease), timolol (Chemical), timolol (Chemical), timolol (Chemical), bradycardia (Disease), timolol (Chemical), cardiomegaly (Disease), infarction (Disease), timolol (Chemical) |
Extract chemical and disease entities from the following text. | Vitamin D3 toxicity in dairy cows. Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentratio... | Chemical/Disease Entities: Vitamin D3 (Chemical), toxicity (Disease), vitamin D3 (Chemical), vitamin D3 (Chemical), hypercalcemia (Disease), hyperphosphatemia (Disease), vitamin D3 (Chemical), Calcium (Chemical), vitamin D3 (Chemical), vitamin D3 (Chemical), milk fever (Disease), milk fever (Disease), vitamin D3 (Chemi... |
Extract chemical and disease entities from the following text. | Diseases of peripheral nerves as seen in the Nigerian African. The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori-motor n... | Chemical/Disease Entities: Diseases of peripheral nerves (Disease), peripheral nerve disease (Disease), Sensori-motor neuropathy (Disease), Guillain-Barr syndrome (Disease), motor neuropathy (Disease), Peripheral neuropathy (Disease), nutritional deficiency (Disease), thiamine (Chemical), riboflavin (Chemical), senso... |
Extract chemical and disease entities from the following text. | A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder. In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effecti... | Chemical/Disease Entities: dothiepin hydrochloride (Chemical), depressive disorder (Disease), dothiepin (Chemical), amitriptyline (Chemical), depressed (Disease), Dothiepin (Chemical), amitriptyline (Chemical), depressive illness (Disease), blurred vision (Disease), dry mouth (Disease), dothiepin (Chemical), amitriptyl... |
Extract chemical and disease entities from the following text. | Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patie... | Chemical/Disease Entities: diazepam (Chemical), propranolol (Chemical), panic disorder (Disease), agoraphobia (Disease), diazepam (Chemical), propranolol (Chemical), panic disorders (Disease), agoraphobia (Disease), impaired immediate free recall (Disease), diazepam (Chemical), propranolol (Chemical), Delayed free reca... |
Extract chemical and disease entities from the following text. | Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat. The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas b... | Chemical/Disease Entities: aspirin (Chemical), N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (Chemical), aspirin (Chemical), N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (Chemical), FANFT (Chemical), FANFT (Chemical), bladder carcinomas (Disease), forestomach tumors (Disease), FANFT (Chemical), aspirin (Chemical), asp... |
Extract chemical and disease entities from the following text. | Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy? The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time cou... | Chemical/Disease Entities: hypotension (Disease), nitroglycerin (Chemical), diabetic autonomic neuropathy (Disease), nitroglycerin (Chemical), diabetic (Disease), autonomic neuropathy (Disease), diabetic (Disease), autonomic neuropathy (Disease), nitroglycerin (Chemical), diabetic (Disease), autonomic neuropathy (Disea... |
Extract chemical and disease entities from the following text. | Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat. Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a range of 1-150 days of DES treatment, pairs of control and DES-treated ... | Chemical/Disease Entities: estrogen (Chemical), adenohypophyseal tumors (Disease), Pituitary tumors (Disease), diethylstilbestrol (Chemical), DES (Chemical), DES (Chemical), DES (Chemical), acriflavine (Chemical), DES (Chemical), DES (Chemical), DES (Chemical), DES (Chemical), DES (Chemical), tumor (Disease) |
Extract chemical and disease entities from the following text. | Triamterene nephrolithiasis complicating dyazide therapy. A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecting... | Chemical/Disease Entities: Triamterene (Chemical), nephrolithiasis (Disease), dyazide (Chemical), triamterene (Chemical), nephrolithiasis (Disease), hydrochlorothiazide-triamterene (Chemical), hypertension (Disease), triamterene (Chemical), uric acid salts (Chemical), triamterene (Chemical), nephrolithiasis (Disease) |
Extract chemical and disease entities from the following text. | Metabolic involvement in adriamycin cardiotoxicity. The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was... | Chemical/Disease Entities: adriamycin (Chemical), cardiotoxicity (Disease), cardiotoxic (Disease), adriamycin (Chemical), Adriamycin (Chemical), phosphorylcreatine (Chemical), adriamycin (Chemical), phophorylcreatine (Chemical), creatine (Chemical), adenosine (Chemical), ATP (Chemical), ATP (Chemical), adriamycin (Chem... |
Extract chemical and disease entities from the following text. | Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin. Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Abnorma... | Chemical/Disease Entities: neurotoxic (Disease), streptomycin (Chemical), Streptomycin (Chemical), Abnormal movements (Disease), deafness (Disease), streptomycin (Chemical), dyskinesias (Disease) |
Extract chemical and disease entities from the following text. | Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis. This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This p... | Chemical/Disease Entities: glomerulonephritis (Disease), rifampin (Chemical), pulmonary tuberculosis (Disease), glomerulonephritis (Disease), rifampin (Chemical), rifampin (Chemical), isoniazid (Chemical), pulmonary tuberculosis (Disease), renal failure (Disease), glomerulonephritis (Disease), glomerulonephritis (Disea... |
Extract chemical and disease entities from the following text. | Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy. Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidatio... | Chemical/Disease Entities: puromycin aminonucleoside (Chemical), nephropathy (Disease), oxygen (Chemical), puromycin aminonucleoside (Chemical), PAN (Chemical), nephropathy (Disease), proteinuria (Disease), proteinuria (Disease), puromycin aminonucleoside (Chemical), PAN (Chemical), thiobarbituric acid (Chemical), Prot... |
Extract chemical and disease entities from the following text. | Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action. The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were stu... | Chemical/Disease Entities: Clomipramine (Chemical), sleep disturbance (Disease), sleep disturbance (Disease), clomipramine (Chemical), clomipramine (Chemical), clomipramine (Chemical), sleep disturbance (Disease), clomipramine (Chemical) |
Extract chemical and disease entities from the following text. | Angioedema following the intravenous administration of metoprolol. A 72-year-old woman was admitted to the hospital with "flash" pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. ... | Chemical/Disease Entities: Angioedema (Disease), metoprolol (Chemical), pulmonary edema (Disease), chest pain (Disease), coronary artery disease (Disease), myocardial infarctions (Disease), hypertension (Disease), diabetes mellitus (Disease), angioedema (Disease), lisinopril (Chemical), angiotensin (Chemical), metoprol... |
Extract chemical and disease entities from the following text. | Effect of coniine on the developing chick embryo. Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or m... | Chemical/Disease Entities: coniine (Chemical), Coniine (Chemical), arthrogryposis (Disease), coniine (Chemical), arthrogryposis (Disease), coniine (Chemical), nicotine (Chemical), coniine (Chemical), nicotine (Chemical), deformations (Disease), nicotine (Chemical), coniine (Chemical), deformations (Disease), coniine (C... |
Extract chemical and disease entities from the following text. | Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension. To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal surgery, EBF was measured using the heat clearance method in 30 patients who underwent postero-lateral i... | Chemical/Disease Entities: prostaglandin E1 (Chemical), trimethaphan (Chemical), hypotension (Disease), prostaglandin E1 (Chemical), PGE1 (Chemical), trimethaphan (Chemical), TMP (Chemical), hypotension (Disease), isoflurane (Chemical), PGE1 (Chemical), TMP (Chemical), hypotensive (Disease), PGE1 (Chemical), TMP (Chemi... |
Extract chemical and disease entities from the following text. | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. Immunohistochemistry with monoclonal antibodies against neurofilament (NF) proteins of middle and high molecular weight class, NF-M and NF-H, was used to study axonal injury in the borderzone of ... | Chemical/Disease Entities: axonal damage (Disease), axonal injury (Disease), injury in the cortex (Disease), lactate (Chemical), Infarcts in substantia nigra pars reticulata (Disease), pilocarpine (Chemical), status epilepticus (Disease), axonal damage (Disease), traumatic (Disease) |
Extract chemical and disease entities from the following text. | Increase of Parkinson disability after fluoxetine medication. Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant d... | Chemical/Disease Entities: Parkinson disability (Disease), fluoxetine (Chemical), Depression (Disease), Parkinson's disease (Disease), motor disability (Disease), idiopathic Parkinson's disease (Disease), antidepressant (Chemical), fluoxetine (Chemical), dopamine (Chemical), fluoxetine (Chemical), Parkinson's disease (... |
Extract chemical and disease entities from the following text. | Acetaminophen-induced hypotension. Through 30 years of widespread use, acetaminophen has been shown to be a remarkably safe medication in therapeutic dosages. The potential for acetaminophen to produce cardiovascular toxicities is very low. However, acetaminophen has been demonstrated to produce symptoms of anaphylaxis... | Chemical/Disease Entities: Acetaminophen (Chemical), hypotension (Disease), acetaminophen (Chemical), acetaminophen (Chemical), cardiovascular toxicities (Disease), acetaminophen (Chemical), anaphylaxis (Disease), hypotension (Disease), critically ill (Disease), hypotension (Disease), acetaminophen (Chemical), allergic... |
Extract chemical and disease entities from the following text. | Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone. An 80-yr-old man developed acute hepatitis shortly after ingesting oral ceftriaxone. Although the transaminases gradually returned to baseline after withholding the beta lactam antibiotic, there was a gradual increase in se... | Chemical/Disease Entities: hepatitis (Disease), autoimmune hemolytic anemia (Disease), erythroblastocytopenia (Disease), ceftriaxone (Chemical), hepatitis (Disease), ceftriaxone (Chemical), beta lactam (Chemical), bilirubin (Chemical), autoimmune hemolytic anemia (Disease), erythroblastocytopenia (Disease), steroids (C... |
Extract chemical and disease entities from the following text. | Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations. Adverse effects of antipsychotics often lead to noncompliance. Thus, clinicians should address patients' concerns about adverse effects and attempt to choose medications that will improve their patients' quality o... | Chemical/Disease Entities: extrapyramidal symptoms (Disease), EPS (Disease), tardive dyskinesia (Disease), orthostatic hypotension (Disease), sexual dysfunction (Disease), weight gain (Disease), EPS (Disease), weight gain (Disease), sexual dysfunction (Disease), seizure (Disease), clozapine (Chemical), agranulocytosis ... |
Extract chemical and disease entities from the following text. | Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation. Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues with a bisbenzylisoquinoline structure. The present study was undertaken to investigate the effects of TET and FAN on the experiment... | Chemical/Disease Entities: tetrandrine (Chemical), fangchinoline (Chemical), thrombosis (Disease), platelet aggregation (Disease), Tetrandrine (Chemical), TET (Chemical), fangchinoline (Chemical), FAN (Chemical), bisbenzylisoquinoline (Chemical), TET (Chemical), FAN (Chemical), thrombosis (Disease), epinephrine (Chemic... |
Extract chemical and disease entities from the following text. | Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive cisplatin. Oncopaz Cooperative Group. BACKGROUND: Although the prevalence of nonsmall cell lung carcinoma (NSCLC) is high among elderly patients, few data are available regarding the efficacy and t... | Chemical/Disease Entities: Gemcitabine (Chemical), vinorelbine (Chemical), nonsmall cell lung carcinoma (Disease), cisplatin (Chemical), nonsmall cell lung carcinoma (Disease), NSCLC (Disease), toxicity (Disease), vinorelbine (Chemical), VNB (Chemical), gemcitabine (Chemical), GEM (Chemical), toxicity (Disease), toxici... |
Extract chemical and disease entities from the following text. | Warfarin-induced artery calcification is accelerated by growth and vitamin D. The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-carboxylation of matrix Gla protein, a calcification inhibitor known to... | Chemical/Disease Entities: Warfarin (Chemical), artery calcification (Disease), vitamin D (Chemical), vitamin D (Chemical), artery calcification (Disease), Warfarin (Chemical), calcification (Disease), artery calcification (Disease), Warfarin (Chemical), Warfarin (Chemical), calcification of the artery (Disease), calci... |
Extract chemical and disease entities from the following text. | Antidepressant-induced mania in bipolar patients: identification of risk factors. BACKGROUND: Concerns about possible risks of switching to mania associated with antidepressants continue to interfere with the establishment of an optimal treatment paradigm for bipolar depression. METHOD: The response of 44 patients meet... | Chemical/Disease Entities: Antidepressant (Chemical), mania (Disease), bipolar (Disease), mania (Disease), antidepressants (Chemical), bipolar depression (Disease), bipolar disorder (Disease), manic (Disease), hypomanic (Disease), DSM-IV bipolar I (Disease), bipolar II (Disease), manic (Disease), antidepressant (Chemic... |
Extract chemical and disease entities from the following text. | Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. We describe a 25-year-old woman with pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consuming a "natural energy" guarana health drink containing a high concentration of caffeine. This case hi... | Chemical/Disease Entities: Caffeine (Chemical), cardiac arrhythmia (Disease), mitral valve prolapse (Disease), ventricular fibrillation (Disease), caffeine (Chemical) |
Extract chemical and disease entities from the following text. | Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports. Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilato... | Chemical/Disease Entities: retention of urine (Disease), fentanyl (Chemical), pain (Disease), Fentanyl (Chemical), fentanyl (Chemical), chest wall rigidity (Disease), hypotension (Disease), respiratory depression (Disease), bradycardia (Disease), urinary bladder retention (Disease), hydronephrosis (Disease), fentanyl (... |
Extract chemical and disease entities from the following text. | Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. Highly active antiretroviral therapy (HAART) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To determine mitochondrial events from... | Chemical/Disease Entities: cardiomyopathy (Disease), lactate (Chemical), AIDS (Disease), cardiomyopathy (Disease), CM (Disease), lactate (Chemical), LA (Chemical), AIDS (Disease), mitochondrial dysfunction (Disease), AIDS (Disease), zidovudine (Chemical), lamivudine (Chemical), indinavir (Chemical), CM (Disease), calci... |
Extract chemical and disease entities from the following text. | Oral contraceptives and the risk of myocardial infarction. BACKGROUND: An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated this association, according to the type of progestagen included in third-generation (i.e., deso... | Chemical/Disease Entities: Oral contraceptives (Chemical), myocardial infarction (Disease), oral contraceptives (Chemical), myocardial infarction (Disease), progestagen (Chemical), desogestrel (Chemical), gestodene (Chemical), levonorgestrel (Chemical), oral contraceptives (Chemical), estrogen (Chemical), myocardial in... |
Extract chemical and disease entities from the following text. | Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats. The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hy... | Chemical/Disease Entities: cocaine (Chemical), locomotor hyperactivity (Disease), locomotor hyperactivity (Disease), cocaine (Chemical), GR 55562 (Chemical), CP 93129 (Chemical), GR 55562 (Chemical), CP 93129 (Chemical), cocaine (Chemical), GR 55562 (Chemical), cocaine (Chemical), locomotor hyperactivity (Disease), GR ... |
Extract chemical and disease entities from the following text. | Ticlopidine-induced cholestatic hepatitis. OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed main characteristics with those of the published cases. CASE SUMMARIES: Two patients developed prolonged cholestatic hepatitis after receiving ticlopi... | Chemical/Disease Entities: Ticlopidine (Chemical), ticlopidine (Chemical), ticlopidine (Chemical), ticlopidine (Chemical), ticlopidine (Chemical), jaundice (Disease), ticlopidine (Chemical), Hepatitis (Disease), ticlopidine (Chemical), ticlopidine (Chemical), cholestasis (Disease), hepatotoxicity (Disease), ticlopidine... |
Extract chemical and disease entities from the following text. | Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome. In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase of the disease. The molecular mechanism(s) leading to salt retention has not been compl... | Chemical/Disease Entities: sodium (Chemical), puromycin aminonucleoside (Chemical), nephrotic syndrome (Disease), nephrotic syndrome (Disease), sodium (Chemical), sodium (Chemical), sodium (Chemical), puromycin aminonucleoside (Chemical), PAN (Chemical), nephrotic syndrome (Disease), sodium (Chemical), aldosterone (Che... |
Extract chemical and disease entities from the following text. | NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydrox... | Chemical/Disease Entities: NO (Chemical), migraine (Disease), calcitonin gene-related peptide (Chemical), CGRP (Chemical), serotonin (Chemical), calcitonin gene-related peptide (Chemical), CGRP (Chemical), serotonin (Chemical), 5-hydroxytriptamine (Chemical), 5-HT (Chemical), headache (Disease), migraine (Disease), nit... |
Extract chemical and disease entities from the following text. | Coronary aneurysm after implantation of a paclitaxel-eluting stent. Formation of coronary aneurysm is a rare complication of stenting with bare metal stents, but based on experimental studies drug-eluting stents may induce toxic effects on the vessel wall with incomplete stent apposition, aneurysm formation and with th... | Chemical/Disease Entities: Coronary aneurysm (Disease), paclitaxel (Chemical), coronary aneurysm (Disease), aneurysm (Disease), thrombosis (Disease), vessel rupture (Disease), coronary aneurysm (Disease), paclitaxel (Chemical), aneurysm (Disease), aneurysm (Disease) |
Extract chemical and disease entities from the following text. | Behavioral effects of urotensin-II centrally administered in mice. Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effect... | Chemical/Disease Entities: urotensin-II (Chemical), Urotensin-II (Chemical), U-II (Chemical), U-II (Chemical), hypertension (Disease), bradycardia (Disease), U-II (Chemical), U-II (Chemical), U-II (Chemical), U-II (Chemical), U-II (Chemical), apomorphine (Chemical), penile erection (Disease), corticosterone (Chemical),... |
Extract chemical and disease entities from the following text. | Recurrent dysphonia and acitretin. We report the case of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regressed after drug withdrawal and reappeared when acitretin was reintroduced. To our knowledge, this is the first case of acitretin-induced dysphonia. This effect may be r... | Chemical/Disease Entities: dysphonia (Disease), acitretin (Chemical), dysphonia (Disease), acitretin (Chemical), acitretin (Chemical), acitretin (Chemical), dysphonia (Disease) |
Extract chemical and disease entities from the following text. | Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Abnormal processing of somatosensory inputs in the central nervous system (central sensitization) is the mechanism accounting for the enhanced pain sensitivity in the skin surrounding tissue injury (secon... | Chemical/Disease Entities: pain (Disease), pain (Disease), tissue injury (Disease), secondary hyperalgesia (Disease), Secondary hyperalgesia (Disease), neurogenic hyperalgesia (Disease), neuropathic pain (Disease), hyperalgesia (Disease), gabapentin (Chemical), neuropathic pain (Disease), gabapentin (Chemical), capsaic... |
Extract chemical and disease entities from the following text. | MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes. In recent years working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on th... | Chemical/Disease Entities: MDMA (Chemical), impaired social and emotional judgement processes (Disease), memory deficits (Disease), MDMA (Chemical), 3,4-methylenedioxymethamphetamine (Chemical), ecstasy (Chemical), MDMA (Chemical), ecstasy (Chemical), ecstasy (Chemical), MDMA (Chemical), MDMA (Chemical), ecstasy (Chemi... |
Extract chemical and disease entities from the following text. | Severe citrate toxicity complicating volunteer apheresis platelet donation. We report a case of severe citrate toxicity during volunteer donor apheresis platelet collection. The donor was a 40-year-old female, first-time apheresis platelet donor. Past medical history was remarkable for hypertension, hyperlipidemia, and... | Chemical/Disease Entities: citrate (Chemical), toxicity (Disease), citrate (Chemical), toxicity (Disease), hypertension (Disease), hyperlipidemia (Disease), depression (Disease), bumetanide (Chemical), pravastatin (Chemical), paroxetine (Chemical), tetany (Disease), calcium gluconate (Chemical), muscle contractions (Di... |
Extract chemical and disease entities from the following text. | Proteinuria after conversion to sirolimus in renal transplant recipients. Sirolimus (SRL) is a new, potent immunosuppressive agent. More recently, proteinuria has been reported as a consequence of sirolimus therapy, although the mechanism has remained unclear. We retrospectively examined the records of 25 renal transpl... | Chemical/Disease Entities: Proteinuria (Disease), sirolimus (Chemical), Sirolimus (Chemical), SRL (Chemical), proteinuria (Disease), sirolimus (Chemical), proteinuria (Disease), SRL (Chemical), SRL (Chemical), chronic allograft nephropathy (Disease), CAN (Disease), neoplasia (Disease), Kaposi's sarcoma (Disease), skin ... |
Extract chemical and disease entities from the following text. | In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat. In cyclophosphamide-induced cystitis in the rat, detrusor function is impaired and the expression and effects of muscarinic receptors altered. Whether or not the neuronal transmission may be affected ... | Chemical/Disease Entities: cyclophosphamide (Chemical), cystitis (Disease), cyclophosphamide (Chemical), cystitis (Disease), cystitis (Disease), cyclophosphamide (Chemical), atropine (Chemical), alpha,beta-methylene adenosine-5'-triphosphate (Chemical), alpha,beta-meATP (Chemical), atropine (Chemical), 4-diphenylacetox... |
Extract chemical and disease entities from the following text. | Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly. OBJECTIVE: To describe associations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities and cognitive function i... | Chemical/Disease Entities: benzodiazepines (Chemical), benzodiazepines (Chemical), BZDs (Chemical), BZDs (Chemical), BZDs (Chemical), oxazepam (Chemical), temazepam (Chemical), zopiclone (Chemical), BZDs (Chemical), dementia (Disease), BZDs (Chemical), BZDs (Chemical), dizziness (Disease), inability to sleep (Disease),... |
Extract chemical and disease entities from the following text. | Acute vocal fold palsy after acute disulfiram intoxication. Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no report of it leading to vocal fold palsy. A 49-year-old woman was transferred to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia o... | Chemical/Disease Entities: vocal fold palsy (Disease), disulfiram (Chemical), peripheral neuropathy (Disease), disulfiram (Chemical), overdose (Disease), vocal fold palsy (Disease), quadriparesis (Disease), pain (Disease), sensory loss (Disease), paresthesia (Disease), disulfiram (Chemical), ALCOHOL (Chemical), ataxia ... |
Extract chemical and disease entities from the following text. | Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia. OBJECTIVES: To correlate optical density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inhibition characteristics of ... | Chemical/Disease Entities: thrombosis (Disease), heparin (Chemical), thrombocytopenia (Disease), heparin (Chemical), thrombocytopenia (Disease), HIT (Disease), thrombosis (Disease), heparin (Chemical), thrombocytopenia (Disease), heparin (Chemical), heparin (Chemical), HIT (Disease), thrombosis (Disease), HIT (Disease)... |
Extract chemical and disease entities from the following text. | Central retinal vein occlusion associated with clomiphene-induced ovulation. OBJECTIVE: To report a case of central retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SETTING: Ophthalmology clinic of an academic hospital. PATIENT(S): A 36-year-old woman referred from the infertility cli... | Chemical/Disease Entities: retinal vein occlusion (Disease), clomiphene (Chemical), retinal vein occlusion (Disease), clomiphene citrate (Chemical), CC (Chemical), infertility (Disease), blurred vision (Disease), CC (Chemical), retinal vein occlusion (Disease), CC (Chemical), retinal vein occlusion (Disease), CC (Chemi... |
Extract chemical and disease entities from the following text. | Nicotine-induced nystagmus correlates with midpontine activation. The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was to delineate brain structures that are involved in NIN generation. Eight healthy volunteers inhaled nicotine in darkness during a functional magnetic resonance i... | Chemical/Disease Entities: Nicotine (Chemical), nystagmus (Disease), nicotine (Chemical), nystagmus (Disease), NIN (Disease), NIN (Disease), nicotine (Chemical), NIN (Disease), oxygen (Chemical), NIN (Disease) |
Extract chemical and disease entities from the following text. | Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats. Studies concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking. The aim of this study is to examine the role of gastric acid back-diffusion, mast cell histamine re... | Chemical/Disease Entities: verapamil (Chemical), gastric hemorrhagic (Disease), ulcers (Disease), atherosclerotic (Disease), gastric hemorrhage (Disease), atherosclerotic (Disease), histamine (Chemical), gastric hemorrhage (Disease), ulcer (Disease), atherosclerosis (Disease), vitamin D2 (Chemical), cholesterol (Chemic... |
Extract chemical and disease entities from the following text. | Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. The aim of this study was to investigate whether autophagy was involved in the progression of heart... | Chemical/Disease Entities: Adriamycin (Chemical), death (Disease), heart failure (Disease), heart failure (Disease), adriamycin (Chemical), heart failure (Disease), adriamycin (Chemical), heart failure (Disease), 3-methyladenine (Chemical), 3MA (Chemical), heart failure (Disease), adriamycin (Chemical), adriamycin (Che... |
Extract chemical and disease entities from the following text. | Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database. INTRODUCTION: Confusion is an adverse drug reaction frequently observed with valproic acid. Some case reports are published in the literature but no systematic study from a sample of patients has bee... | Chemical/Disease Entities: Confusion (Disease), valproic acid (Chemical), Confusion (Disease), valproic acid (Chemical), confusion (Disease), valproic acid (Chemical), confusion (Disease), valproic acid (Chemical), Confusion (Disease), valproic acid (Chemical), confusion (Disease), valproic acid (Chemical) |
Extract chemical and disease entities from the following text. | Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. It has been consistently shown that ecstasy users display impairments in learning and memory performance. In addition, working memory processing in ecstasy users has been shown to be associated with neural alterations... | Chemical/Disease Entities: ecstasy (Chemical), ecstasy (Chemical), ecstasy (Chemical), ecstasy (Chemical), cannabis (Chemical), ecstasy (Chemical), cannabis (Chemical), hyperactivity (Disease), cannabis (Chemical), Ecstasy (Chemical), cannabis (Chemical), ecstasy (Chemical), hyperactivity (Disease), Ecstasy (Chemical),... |
Extract chemical and disease entities from the following text. | Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis. BACKGROUND: Direct thrombin inhibitors (DTIs) provide an alternative method of anticoagulation for patients with a history of heparin-induced thrombocytopenia (HIT) or H... | Chemical/Disease Entities: argatroban (Chemical), heparin (Chemical), thrombocytopenia (Disease), thrombosis (Disease), heparin (Chemical), thrombocytopenia (Disease), HIT (Disease), HIT (Disease), thrombosis (Disease), HITT (Disease), critically ill (Disease), HITT (Disease), argatroban (Chemical), argatroban (Chemica... |
Extract chemical and disease entities from the following text. | Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome. Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the commonest drug-induced ALF in South Asia. Prospective studies on ATT-ALF are lacking. The current study prospectively evaluated t... | Chemical/Disease Entities: Antituberculosis (Chemical), acute liver failure (Disease), Antituberculosis (Chemical), acute liver failure (Disease), ALF (Disease), ALF (Disease), ALF (Disease), ALF (Disease), ALF (Disease), hepatitis virus infection (Disease), tuberculosis (Disease), ALF (Disease), icterus (Disease), enc... |
Extract chemical and disease entities from the following text. | Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution. Central nervous system (CNS) complications during treatment of childhood acute lymphoblastic leukemia (ALL) remain a challenging clinical problem. Outcome improvement with more intensive chemotherapy... | Chemical/Disease Entities: Central nervous system complications (Disease), acute lymphoblastic leukemia (Disease), Central nervous system (CNS) complications (Disease), acute lymphoblastic leukemia (Disease), ALL (Disease), neurological complications (Disease), ALL (Disease), leukemic infiltration (Disease), peripheral... |
Extract chemical and disease entities from the following text. | Safety of capecitabine: a review. IMPORTANCE OF THE FIELD: Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid tumors, including colorectal, breast and head and neck cancers, for > 40 years. AREAS COVERED IN THIS REVIEW: This article reviews the pharmacology and... | Chemical/Disease Entities: capecitabine (Chemical), Fluoropyrimidines (Chemical), 5-fluorouracil (Chemical), 5-FU (Chemical), tumors (Disease), capecitabine (Chemical), capecitabine (Chemical), renal and kidney disease (Disease), capecitabine (Chemical), Capecitabine (Chemical), 5-FU (Chemical), capecitabine (Chemical)... |
Extract chemical and disease entities from the following text. | Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies. OBJECTIVE: The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and s... | Chemical/Disease Entities: neurotensin (Chemical), haloperidol (Chemical), parkinsonian catalepsy (Disease), neurotensin (Chemical), neurotensin (Chemical), haloperidol (Chemical), parkinsonian symptoms (Disease), neurotensin (Chemical), haloperidol (Chemical), parkinsonian catalepsy (Disease), neurotensin (Chemical), ... |
Extract chemical and disease entities from the following text. | Antihypertensive drugs and depression: a reappraisal. Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically physically ill out-patients completed a mood rating scale at regular intervals for one year. The results showed a high prevalence of depression in both groups of pati... | Chemical/Disease Entities: depression (Disease), hypertensive (Disease), hypertensive (Disease), depression (Disease), hypertensive (Disease), Hypertensive (Disease), psychiatric (Disease), depression (Disease), depressions (Disease), methyl dopa (Chemical), psychiatric (Disease) |
Extract chemical and disease entities from the following text. | Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside-induced hypotension. The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood ... | Chemical/Disease Entities: nitroprusside (Chemical), hypotension (Disease), sodium nitroprusside (Chemical), nitroprusside (Chemical), H2O (Chemical), H2O (Chemical), nitroprusside (Chemical), decrease in arterial blood pressure (Disease), decreased cardiac output (Disease), Nitroprusside (Chemical), decreases in arter... |
Extract chemical and disease entities from the following text. | Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs. L-Dopa (5 mg/kg i.v.) decreased blood pressure and heart rate after extracerebral decarboxylase inhibition with MK-486 (25 mg/kg i.v.) in anesthetize MAO-inhibited dogs. In addition, reflex bradycardia caused by injected no... | Chemical/Disease Entities: bradycardia (Disease), L-dopa (Chemical), dopamine (Chemical), L-Dopa (Chemical), MK-486 (Chemical), MAO (Chemical), bradycardia (Disease), norepinephrine (Chemical), L-dopa (Chemical), DL-Threo-dihydroxyphenylserine (Chemical), norepinephrine (Chemical), FLA-63 (Chemical), dopamine (Chemical... |
Extract chemical and disease entities from the following text. | Cocaine-induced myocardial infarction: clinical observations and pathogenetic considerations. Clinical and experimental data published to date suggest several possible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with preexisting, high-grade coronary arterial narrowing, acute my... | Chemical/Disease Entities: Cocaine (Chemical), myocardial infarction (Disease), cocaine (Chemical), acute myocardial infarction (Disease), acute myocardial infarction (Disease), oxygen (Chemical), cocaine (Chemical), atherosclerotic obstruction (Disease), coronary occlusion (Disease), spasm (Disease), thrombus (Disease... |
Extract chemical and disease entities from the following text. | Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings. The rabbit syndrome is an extrapyramidal side effect associated with chronic neuroleptic therapy. Its occurrence in a patient being treated with imipramine is described, representing the first reported case of this syndrome in conjunction ... | Chemical/Disease Entities: Rabbit syndrome (Disease), antidepressant (Chemical), rabbit syndrome (Disease), imipramine (Chemical), antidepressants (Chemical), decreased basal ganglia perfusion (Disease), movement disorder (Disease), rabbit syndrome (Disease) |
Extract chemical and disease entities from the following text. | Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease. The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 micrograms/mL) were compared in... | Chemical/Disease Entities: ipratropium bromide (Chemical), theophylline (Chemical), chronic obstructive pulmonary disease (Disease), ipratropium bromide (Chemical), theophylline (Chemical), chronic obstructive pulmonary disease (Disease), ipratropium (Chemical), theophylline (Chemical), ipratropium (Chemical), theophyl... |
Extract chemical and disease entities from the following text. | Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats. Renal papillary necrosis (RPN) and a decreased urinary concentrating ability developed during continuous long-term treatment with aspirin and paracetamol in female Fischer 344 rats. Renal structure and concentrating ab... | Chemical/Disease Entities: nephropathy (Disease), Renal papillary necrosis (Disease), RPN (Disease), aspirin (Chemical), paracetamol (Chemical), RPN (Disease) |
Extract chemical and disease entities from the following text. | Less frequent lithium administration and lower urine volume. OBJECTIVE: This study was designed to determine whether patients maintained on a regimen of lithium on a once-per-day schedule have lower urine volumes than do patients receiving multiple doses per day. METHOD: This was a cross-sectional study of 85 patients ... | Chemical/Disease Entities: lithium (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), creatinine (Chemical), lithium (Chemical), lithium (Chemical), lithium (Chemical), creatinine (Chemical), lithium (Chemical), Lithium (Chemical), polyuria (Disease) |
Extract chemical and disease entities from the following text. | Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues. Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model. Antitumor activity was studied using a tumor growth delay assay. Acute norma... | Chemical/Disease Entities: adriamycin (Chemical), hyperthermia (Disease), tumor (Disease), Adriamycin (Chemical), toxicities (Disease), hyperthermia (Disease), tumor (Disease), toxicities (Disease), leukopenia (Disease), thrombocytopenia (Disease), toxicities (Disease), hyperthermia (Disease), Adriamycin (Chemical), hy... |
Extract chemical and disease entities from the following text. | Prazosin-induced stress incontinence. A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. Prazosin exerts its antihypertensive effects through vasodilatation caused by selective blockade of postsynaptic alpha-1 adrenergic receptors. As an alpha-blocker, it also exerts a ... | Chemical/Disease Entities: Prazosin (Chemical), stress incontinence (Disease), stress incontinence (Disease), prazosin (Chemical), Prazosin (Chemical), prazosin (Chemical), verapamil (Chemical), incontinence (Disease), stress incontinence (Disease), prazosin (Chemical), incontinence (Disease) |
Extract chemical and disease entities from the following text. | Myocardial infarction following sublingual administration of isosorbide dinitrate. A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we discuss the role o... | Chemical/Disease Entities: Myocardial infarction (Disease), isosorbide dinitrate (Chemical), necrosis (Disease), myocardial infarction (Disease), isosorbide dinitrate (Chemical), spasm (Disease), hypotension (Disease), myocardial ischemia (Disease), coronary arterial stenosis (Disease), acute coronary insufficiency (Di... |
Extract chemical and disease entities from the following text. | Fluoxetine-induced akathisia: clinical and theoretical implications. Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and ma... | Chemical/Disease Entities: Fluoxetine (Chemical), akathisia (Disease), fluoxetine (Chemical), obsessive compulsive disorder (Disease), major depression (Disease), akathisia (Disease), fluoxetine (Chemical), anxiety (Disease), akathisia (Disease), akathisia (Disease), fluoxetine (Chemical), akathisia (Disease), Akathisi... |
Extract chemical and disease entities from the following text. | Chronic active hepatitis associated with diclofenac sodium therapy. Diclofenac sodium (Voltarol, Geigy Pharmaceuticals) is a non-steroidal anti-inflammatory derivative of phenylacetic acid. Although generally well-tolerated, asymptomatic abnormalities of liver function have been recorded and, less commonly, severe hepa... | Chemical/Disease Entities: Chronic active hepatitis (Disease), diclofenac sodium (Chemical), Diclofenac sodium (Chemical), Voltarol (Chemical), phenylacetic acid (Chemical), abnormalities of liver function (Disease), hepatitis (Disease), diclofenac (Chemical), chronic active hepatitis (Disease), diclofenac sodium (Chem... |
Extract chemical and disease entities from the following text. | Stroke associated with cocaine use. We describe eight patients in whom cocaine use was related to stroke and review 39 cases from the literature. Among these 47 patients the mean (+/- SD) age was 32.5 +/- 12.1 years; 76% (34/45) were men. Stroke followed cocaine use by inhalation, intranasal, intravenous, and intramusc... | Chemical/Disease Entities: Stroke (Disease), cocaine (Chemical), cocaine (Chemical), stroke (Disease), Stroke (Disease), cocaine (Chemical), Intracranial aneurysms (Disease), arteriovenous malformations (Disease), cerebral vasculitis (Disease), Cerebral infarction (Disease), intracerebral hemorrhage (Disease), subarach... |
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