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+ # TCGA-PRAD Biochemical Recurrence Dataset
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+
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+ This dataset was curated as part of a research project aimed at predicting biochemical recurrence (BCR) in prostate cancer directly from H&E-stained prostatectomy specimens.
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+ Based on the **TCGA Prostate Adenocarcinoma (TCGA-PRAD)** cohort, we provides curated labels for biochemical recurrence along with packed diagnostic whole-slide images and corresponding tissue masks.
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+ ## 📂 Repository Structure
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+
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+ The dataset is organized into the following folders and files:
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+
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+ `whole-slide-images/`
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+ - Packed WSIs for the **298 TCGA-PRAD patients** included in our study in `.tif` format
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+
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+ `tissue-masks/`
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+ - Corresponding binary tissue segmentation masks, also in `.tif` format (`0 = background`, `1 = tissue`)
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+
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+ `biotab-xml/`
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+ - Original **case-specific biotab XML files** for **403 TCGA-PRAD patients** with at least one diagnostic slide.
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+ - Used for extracting BCR status and metadata.
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+
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+ `metadata.csv`
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+ - metadata prased from biotab XML files for all the **403 TCGA-PRAD patients** with diagnostic slides.
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+ `bcr.csv`
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+ - Curated biochemical recurrence labels for the **298 TCGA-PRAD patients** included in our study
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+ - `case_id`: TCGA case ID
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+ - `event`: `1` if biochemical recurrence occurred, `0` otherwise
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+ - `follow_up_y`: Time to event (if `event=1`) or time to last follow-up (if `event=0`), in **years**
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+
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+
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+ ## 🧬 Label Curation Process
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+
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+ Biochemical recurrence labels were curated from the biotab XML files, based on the following logic:
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+
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+ - **Event = 1 (Biochemical Recurrence):**
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+ - `biochemical_recurrence_indicator = YES`, using `days_to_biochemical_recurrence_first` as time to event.
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+ - OR `new_tumor_event_type = "Biochemical evidence of disease"` with available `new_tumor_event_dx_days_to`.
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+
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+ - **Event = 0 (No Recurrence):**
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+ - `biochemical_recurrence_indicator = NO` and no tumor event indicating recurrence.
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+ - Time to last follow-up taken from `last_contact_days_to`.
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+
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+ Patients with incomplete or contradictory information were excluded (105 patients).
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+
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+ ## 🧾 Citation
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+
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+ If you use this dataset in your research, please cite:
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+
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+ > to be added soon
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+
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+ ## 🔒 License
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+
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+ This dataset is derived from **TCGA**, which is distributed under the [TCGA Data Use Certification](https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga/history/policies).
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+ Redistribution of image data is permitted for academic and non-commercial research purposes only.
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+
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+ ---
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+ tags:
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+ - medical
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+ - histology
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+ - tcga
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+ size_categories:
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+ - n<1K
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+ ---