accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q71RH2 | TLC3B_HUMAN | TLC domain-containing protein 3B | Homo | <M><L><T><P><M><V><A><G><G><V><V><F><P><G><L><F><L><L><S><K><N><T><L><Q><R><L><P><Q><L><R><W><E><E><A><D><A><V><I><V><S><A><R><L><V><S><S><V><Q><A><I><M><A><S><T><A><G><Y><I><V><S><T><S><C><K><H><I><I><D><D><Q><H><W><L><S><S><A><Y><T><Q><F><A><V><P><Y><F><I><Y><D><I><Y><A><M><F><L><C><H><W><H><K><H><Q><V><K><G><H><G><G><D><D><G><A><A><R><A><P><G><S><T><W><A><I><A><R><G><Y><L><H><K><E><F><L><M><V><L><H><H><A><A><M><V><L><V><C><F><P><L><S><V><V><W><R><Q><G><K><G><D><F><F><L><G><C><M><L><M><A><E><V><S><T><P><F><V><C><L><G><K><I><L><I><Q><Y><K><Q><Q><H><T><L><L><H><K><V><N><G><A><L><M><L><L><S><F><L><C><C><R><V><L><L><F><P><Y><L><Y><W><A><Y><G><R><H><A><G><L><P><L><L><A><V><P><L><A><I><P><A><H><V><N><L><G><A><A><L><L><L><A><P><Q><L><Y><W><F><F><L><I><C><R><G><A><C><R><L><F><W><P><R><S><R><P><P><P><A><C><Q><A><Q><D> | Involved in ceramide synthesis.<BOP> | Q71RH2 |
Q9UK12 | ZN222_HUMAN | Zinc finger protein 222 | Homo | <M><A><K><L><Y><E><A><V><T><F><K><D><V><A><V><I><F><T><E><E><E><L><G><L><L><D><P><A><Q><R><K><L><Y><R><D><V><M><L><E><N><F><R><N><L><L><S><V><G><G><K><I><Q><T><E><M><E><T><V><P><E><A><G><T><H><E><E><F><S><C><K><Q><I><W><E><Q><I><A><S><D><L><T><R><S><Q><D><T><T><I><S><N><S><Q><L><F><E><Q><D><D><N><P><S><Q><I><K><A><R><L><S><T><V><H><T><R><E><K><P><F><Q><G><E><N><C><K><Q><F><F><S><D><V><S><F><F><D><L><P><Q><Q><L><Y><S><G><E><K><S><H><T><C><D><E><C><G><K><S><F><C><Y><I><S><A><L><H><I><H><Q><R><V><H><M><G><V><K><C><Y><K><C><D><V><C><G><K><E><F><S><Q><S><S><R><L><Q><T><H><Q><R><V><H><T><G><E><K><P><F><K><C><E><Q><C><G><K><G><F><R><C><R><S><A><L><K><V><H><C><K><L><H><M><R><E><K><P><Y><N><C><E><K><C><G><K><A><F><M><H><N><F><Q><L><Q><K><H><H><R><I><H><T><G><E><K><P><F><K><C><E><I><C><G><K><S><F><C><L><R><S><S><L><N><R><H><C><M><V><H><T><A><E><K><L><Y><K><S><E><K><Y><G><R><G><F><I><D><R><L><D><L><H><K><H><Q><M><I><H><M><G><Q><K><P><Y><N><C><K><E><C><G><K><S><F><K><W><S><S><Y><L><L><V><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><Y><I><S><K><S><G><L><D><F><H><H><R><T><H><T><G><E><R><S><Y><N><C><D><N><C><G><K><S><F><R><H><A><S><S><I><L><N><H><K><K><L><H><C><Q><R><K><P><L><K><C><E><D><C><G><K><R><L><V><C><R><S><Y><C><K><D><Q><Q><R><D><H><S><G><E><N><P><S><K><C><E><D><C><G><K><R><Y><K><R><R><L><N><L><D><I><I><L><S><L><F><L><N><D><I> | May be involved in transcriptional regulation.<BOP> | Q9UK12 |
Q8WWB3 | DYDC1_HUMAN | DPY30 domain-containing protein 1 | Homo | <M><E><S><I><Y><L><Q><K><H><L><G><A><C><L><T><Q><G><L><A><E><V><A><R><V><R><P><V><D><P><I><E><Y><L><A><L><W><I><Y><K><Y><K><E><N><V><T><M><E><Q><L><R><Q><K><E><M><A><K><L><E><R><E><R><E><L><A><L><M><E><Q><E><M><M><E><R><L><K><A><E><E><L><L><L><Q><Q><Q><Q><L><A><L><Q><L><E><L><E><M><Q><E><K><E><R><Q><R><I><Q><E><L><Q><R><A><Q><E><Q><L><G><K><E><M><R><M><N><M><E><N><L><V><R><N><E><D><I><L><H><S><E><E><A><T><L><D><S><G><K><T><L><A><E><I><S><D><R><Y><G><A><P><N><L><S><R><V><E><E><L><D><E><P><M><F><S><D><I><A><L><N><I><D><Q><D><L> | Plays a crucial role during acrosome biogenesis.<BOP> | Q8WWB3 |
Q6UX98 | ZDH24_HUMAN | Zinc finger DHHC domain-containing protein 24 | Homo | <M><G><Q><P><W><A><A><G><S><T><D><G><A><P><A><Q><L><P><L><V><L><T><A><L><W><A><A><A><V><G><L><E><L><A><Y><V><L><V><L><G><P><G><P><P><P><L><G><P><L><A><R><A><L><Q><L><A><L><A><A><F><Q><L><L><N><L><L><G><N><V><G><L><F><L><R><S><D><P><S><I><R><G><V><M><L><A><G><R><G><L><G><Q><G><W><A><Y><C><Y><Q><C><Q><S><Q><V><P><P><R><S><G><H><C><S><A><C><R><V><C><I><L><R><R><D><H><H><C><R><L><L><G><R><C><V><G><F><G><N><Y><R><P><F><L><C><L><L><L><H><A><A><G><V><L><L><H><V><S><V><L><L><G><P><A><L><S><A><L><L><R><A><H><T><P><L><H><M><A><A><L><L><L><L><P><W><L><M><L><L><T><G><R><V><S><L><A><Q><F><A><L><A><F><V><T><D><T><C><V><A><G><A><L><L><C><G><A><G><L><L><F><H><G><M><L><L><L><R><G><Q><T><T><W><E><W><A><R><G><Q><H><S><Y><D><L><G><P><C><H><N><L><Q><A><A><L><G><P><R><W><A><L><V><W><L><W><P><F><L><A><S><P><L><P><G><D><G><I><T><F><Q><T><T><A><D><V><G><H><T><A><S> | Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.<BOP> | Q6UX98 |
P11926 | DCOR_HUMAN | Ornithine decarboxylase | Homo | <M><N><N><F><G><N><E><E><F><D><C><H><F><L><D><E><G><F><T><A><K><D><I><L><D><Q><K><I><N><E><V><S><S><S><D><D><K><D><A><F><Y><V><A><D><L><G><D><I><L><K><K><H><L><R><W><L><K><A><L><P><R><V><T><P><F><Y><A><V><K><C><N><D><S><K><A><I><V><K><T><L><A><A><T><G><T><G><F><D><C><A><S><K><T><E><I><Q><L><V><Q><S><L><G><V><P><P><E><R><I><I><Y><A><N><P><C><K><Q><V><S><Q><I><K><Y><A><A><N><N><G><V><Q><M><M><T><F><D><S><E><V><E><L><M><K><V><A><R><A><H><P><K><A><K><L><V><L><R><I><A><T><D><D><S><K><A><V><C><R><L><S><V><K><F><G><A><T><L><R><T><S><R><L><L><L><E><R><A><K><E><L><N><I><D><V><V><G><V><S><F><H><V><G><S><G><C><T><D><P><E><T><F><V><Q><A><I><S><D><A><R><C><V><F><D><M><G><A><E><V><G><F><S><M><Y><L><L><D><I><G><G><G><F><P><G><S><E><D><V><K><L><K><F><E><E><I><T><G><V><I><N><P><A><L><D><K><Y><F><P><S><D><S><G><V><R><I><I><A><E><P><G><R><Y><Y><V><A><S><A><F><T><L><A><V><N><I><I><A><K><K><I><V><L><K><E><Q><T><G><S><D><D><E><D><E><S><S><E><Q><T><F><M><Y><Y><V><N><D><G><V><Y><G><S><F><N><C><I><L><Y><D><H><A><H><V><K><P><L><L><Q><K><R><P><K><P><D><E><K><Y><Y><S><S><S><I><W><G><P><T><C><D><G><L><D><R><I><V><E><R><C><D><L><P><E><M><H><V><G><D><W><M><L><F><E><N><M><G><A><Y><T><V><A><A><A><S><T><F><N><G><F><Q><R><P><T><I><Y><Y><V><M><S><G><P><A><W><Q><L><M><Q><Q><F><Q><N><P><D><F><P><P><E><V><E><E><Q><D><A><S><T><L><P><V><S><C><A><W><E><S><G><M><K><R><H><R><A><A><C><A><S><A><S><I><N><V> | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.<BOP> | P11926 |
P31415 | CASQ1_HUMAN | Calsequestrin, skeletal muscle isoform | Homo | <M><S><A><T><D><R><M><G><P><R><A><V><P><G><L><R><L><A><L><L><L><L><L><V><L><G><T><P><K><S><G><V><Q><G><Q><E><G><L><D><F><P><E><Y><D><G><V><D><R><V><I><N><V><N><A><K><N><Y><K><N><V><F><K><K><Y><E><V><L><A><L><L><Y><H><E><P><P><E><D><D><K><A><S><Q><R><Q><F><E><M><E><E><L><I><L><E><L><A><A><Q><V><L><E><D><K><G><V><G><F><G><L><V><D><S><E><K><D><A><A><V><A><K><K><L><G><L><T><E><V><D><S><M><Y><V><F><K><G><D><E><V><I><E><Y><D><G><E><F><S><A><D><T><I><V><E><F><L><L><D><V><L><E><D><P><V><E><L><I><E><G><E><R><E><L><Q><A><F><E><N><I><E><D><E><I><K><L><I><G><Y><F><K><S><K><D><S><E><H><Y><K><A><F><E><D><A><A><E><E><F><H><P><Y><I><P><F><F><A><T><F><D><S><K><V><A><K><K><L><T><L><K><L><N><E><I><D><F><Y><E><A><F><M><E><E><P><V><T><I><P><D><K><P><N><S><E><E><E><I><V><N><F><V><E><E><H><R><R><S><T><L><R><K><L><K><P><E><S><M><Y><E><T><W><E><D><D><M><D><G><I><H><I><V><A><F><A><E><E><A><D><P><D><G><F><E><F><L><E><T><L><K><A><V><A><Q><D><N><T><E><N><P><D><L><S><I><I><W><I><D><P><D><D><F><P><L><L><V><P><Y><W><E><K><T><F><D><I><D><L><S><A><P><Q><I><G><V><V><N><V><T><D><A><D><S><V><W><M><E><M><D><D><E><E><D><L><P><S><A><E><E><L><E><D><W><L><E><D><V><L><E><G><E><I><N><T><E><D><D><D><D><D><D><D><D> | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle . Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions . Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity .<BOP> | P31415 |
P01848 | TRAC_HUMAN | T cell receptor alpha chain constant | Homo | <I><Q><N><P><D><P><A><V><Y><Q><L><R><D><S><K><S><S><D><K><S><V><C><L><F><T><D><F><D><S><Q><T><N><V><S><Q><S><K><D><S><D><V><Y><I><T><D><K><T><V><L><D><M><R><S><M><D><F><K><S><N><S><A><V><A><W><S><N><K><S><D><F><A><C><A><N><A><F><N><N><S><I><I><P><E><D><T><F><F><P><S><P><E><S><S><C><D><V><K><L><V><E><K><S><F><E><T><D><T><N><L><N><F><Q><N><L><S><V><I><G><F><R><I><L><L><L><K><V><A><G><F><N><L><L><M><T><L><R><L><W><S><S> | Constant region of T cell receptor (TR) alpha chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrath | P01848 |
P15529 | MCP_HUMAN | Trophoblast leukocyte common antigen | Homo | <M><E><P><P><G><R><R><E><C><P><F><P><S><W><R><F><P><G><L><L><L><A><A><M><V><L><L><L><Y><S><F><S><D><A><C><E><E><P><P><T><F><E><A><M><E><L><I><G><K><P><K><P><Y><Y><E><I><G><E><R><V><D><Y><K><C><K><K><G><Y><F><Y><I><P><P><L><A><T><H><T><I><C><D><R><N><H><T><W><L><P><V><S><D><D><A><C><Y><R><E><T><C><P><Y><I><R><D><P><L><N><G><Q><A><V><P><A><N><G><T><Y><E><F><G><Y><Q><M><H><F><I><C><N><E><G><Y><Y><L><I><G><E><E><I><L><Y><C><E><L><K><G><S><V><A><I><W><S><G><K><P><P><I><C><E><K><V><L><C><T><P><P><P><K><I><K><N><G><K><H><T><F><S><E><V><E><V><F><E><Y><L><D><A><V><T><Y><S><C><D><P><A><P><G><P><D><P><F><S><L><I><G><E><S><T><I><Y><C><G><D><N><S><V><W><S><R><A><A><P><E><C><K><V><V><K><C><R><F><P><V><V><E><N><G><K><Q><I><S><G><F><G><K><K><F><Y><Y><K><A><T><V><M><F><E><C><D><K><G><F><Y><L><D><G><S><D><T><I><V><C><D><S><N><S><T><W><D><P><P><V><P><K><C><L><K><V><L><P><P><S><S><T><K><P><P><A><L><S><H><S><V><S><T><S><S><T><T><K><S><P><A><S><S><A><S><G><P><R><P><T><Y><K><P><P><V><S><N><Y><P><G><Y><P><K><P><E><E><G><I><L><D><S><L><D><V><W><V><I><A><V><I><V><I><A><I><V><V><G><V><A><V><I><C><V><V><P><Y><R><Y><L><Q><R><R><K><K><K><G><T><Y><L><T><D><E><T><H><R><E><V><K><F><T><S><L> | (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes .<BOP> | P15529 |
P18405 | S5A1_HUMAN | Steroid 5-alpha-reductase 1 | Homo | <M><A><T><A><T><G><V><A><E><E><R><L><L><A><A><L><A><Y><L><Q><C><A><V><G><C><A><V><F><A><R><N><R><Q><T><N><S><V><Y><G><R><H><A><L><P><S><H><R><L><R><V><P><A><R><A><A><W><V><V><Q><E><L><P><S><L><A><L><P><L><Y><Q><Y><A><S><E><S><A><P><R><L><R><S><A><P><N><C><I><L><L><A><M><F><L><V><H><Y><G><H><R><C><L><I><Y><P><F><L><M><R><G><G><K><P><M><P><L><L><A><C><T><M><A><I><M><F><C><T><C><N><G><Y><L><Q><S><R><Y><L><S><H><C><A><V><Y><A><D><D><W><V><T><D><P><R><F><L><I><G><F><G><L><W><L><T><G><M><L><I><N><I><H><S><D><H><I><L><R><N><L><R><K><P><G><D><T><G><Y><K><I><P><R><G><G><L><F><E><Y><V><T><A><A><N><Y><F><G><E><I><M><E><W><C><G><Y><A><L><A><S><W><S><V><Q><G><A><A><F><A><F><F><T><F><C><F><L><S><G><R><A><K><E><H><H><E><W><Y><L><R><K><F><E><E><Y><P><K><F><R><K><I><I><I><P><F><L><F> | Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.<BOP> | P18405 |
Q9UBL9 | P2RX2_HUMAN | Purinergic receptor | Homo | <M><A><A><A><Q><P><K><Y><P><A><G><A><T><A><R><R><L><A><R><G><C><W><S><A><L><W><D><Y><E><T><P><K><V><I><V><V><R><N><R><R><L><G><V><L><Y><R><A><V><Q><L><L><I><L><L><Y><F><V><W><Y><V><F><I><V><Q><K><S><Y><Q><E><S><E><T><G><P><E><S><S><I><I><T><K><V><K><G><I><T><T><S><E><H><K><V><W><D><V><E><E><Y><V><K><P><P><E><G><G><S><V><F><S><I><I><T><R><V><E><A><T><H><S><Q><T><Q><G><T><C><P><E><S><I><R><V><H><N><A><T><C><L><S><D><A><D><C><V><A><G><E><L><D><M><L><G><N><G><L><R><T><G><R><C><V><P><Y><Y><Q><G><P><S><K><T><C><E><V><F><G><W><C><P><V><E><D><G><A><S><V><S><Q><F><L><G><T><M><A><P><N><F><T><I><L><I><K><N><S><I><H><Y><P><K><F><H><F><S><K><G><N><I><A><D><R><T><D><G><Y><L><K><R><C><T><F><H><E><A><S><D><L><Y><C><P><I><F><K><L><G><F><I><V><E><K><A><G><E><S><F><T><E><L><A><H><K><G><G><V><I><G><V><I><I><N><W><D><C><D><L><D><L><P><A><S><E><C><N><P><K><Y><S><F><R><R><L><D><P><K><H><V><P><A><S><S><G><Y><N><F><R><F><A><K><Y><Y><K><I><N><G><T><T><T><R><T><L><I><K><A><Y><G><I><R><I><D><V><I><V><H><G><Q><A><G><K><F><S><L><I><P><T><I><I><N><L><A><T><A><L><T><S><V><G><V><G><S><F><L><C><D><W><I><L><L><T><F><M><N><K><N><K><V><Y><S><H><K><K><F><D><K><V><C><T><P><S><H><P><S><G><S><W><P><V><T><L><A><R><V><L><G><Q><A><P><P><E><P><G><H><R><S><E><D><Q><H><P><S><P><P><S><G><Q><E><G><Q><Q><G><A><E><C><G><P><A><F><P><P><L><R><P><C><P><I><S><A><P><S><E><Q><M><V><D><T><P><A><S><E><P><A><Q><A><S><T><P><T><D><P><K><G><L><A><Q><L> | Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.<BOP> | Q9UBL9 |
P10720 | PF4V_HUMAN | Platelet factor 4 variant(6-74) | Homo | <M><S><S><A><A><R><S><R><L><T><R><A><T><R><Q><E><M><L><F><L><A><L><L><L><L><P><V><V><V><A><F><A><R><A><E><A><E><E><D><G><D><L><Q><C><L><C><V><K><T><T><S><Q><V><R><P><R><H><I><T><S><L><E><V><I><K><A><G><P><H><C><P><T><A><Q><L><I><A><T><L><K><N><G><R><K><I><C><L><D><L><Q><A><L><L><Y><K><K><I><I><K><E><H><L><E><S> | Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).<BOP> | P10720 |
P20718 | GRAH_HUMAN | Cytotoxic serine protease C | Homo | <M><Q><P><F><L><L><L><L><A><F><L><L><T><P><G><A><G><T><E><E><I><I><G><G><H><E><A><K><P><H><S><R><P><Y><M><A><F><V><Q><F><L><Q><E><K><S><R><K><R><C><G><G><I><L><V><R><K><D><F><V><L><T><A><A><H><C><Q><G><S><S><I><N><V><T><L><G><A><H><N><I><K><E><Q><E><R><T><Q><Q><F><I><P><V><K><R><P><I><P><H><P><A><Y><N><P><K><N><F><S><N><D><I><M><L><L><Q><L><E><R><K><A><K><W><T><T><A><V><R><P><L><R><L><P><S><S><K><A><Q><V><K><P><G><Q><L><C><S><V><A><G><W><G><Y><V><S><M><S><T><L><A><T><T><L><Q><E><V><L><L><T><V><Q><K><D><C><Q><C><E><R><L><F><H><G><N><Y><S><R><A><T><E><I><C><V><G><D><P><K><K><T><Q><T><G><F><K><G><D><S><G><G><P><L><V><C><K><D><V><A><Q><G><I><L><S><Y><G><N><K><K><G><T><P><P><G><V><Y><I><K><V><S><H><F><L><P><W><I><K><R><T><M><K><R><L> | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<BOP> | P20718 |
O14618 | CCS_HUMAN | Superoxide dismutase copper chaperone | Homo | <M><A><S><D><S><G><N><Q><G><T><L><C><T><L><E><F><A><V><Q><M><T><C><Q><S><C><V><D><A><V><R><K><S><L><Q><G><V><A><G><V><Q><D><V><E><V><H><L><E><D><Q><M><V><L><V><H><T><T><L><P><S><Q><E><V><Q><A><L><L><E><G><T><G><R><Q><A><V><L><K><G><M><G><S><G><Q><L><Q><N><L><G><A><A><V><A><I><L><G><G><P><G><T><V><Q><G><V><V><R><F><L><Q><L><T><P><E><R><C><L><I><E><G><T><I><D><G><L><E><P><G><L><H><G><L><H><V><H><Q><Y><G><D><L><T><N><N><C><N><S><C><G><N><H><F><N><P><D><G><A><S><H><G><G><P><Q><D><S><D><R><H><R><G><D><L><G><N><V><R><A><D><A><D><G><R><A><I><F><R><M><E><D><E><Q><L><K><V><W><D><V><I><G><R><S><L><I><I><D><E><G><E><D><D><L><G><R><G><G><H><P><L><S><K><I><T><G><N><S><G><E><R><L><A><C><G><I><I><A><R><S><A><G><L><F><Q><N><P><K><Q><I><C><S><C><D><G><L><T><I><W><E><E><R><G><R><P><I><A><G><K><G><R><K><E><S><A><Q><P><P><A><H><L> | Delivers copper to copper zinc superoxide dismutase (SOD1).<BOP> | O14618 |
Q6ZNB7 | ALKMO_HUMAN | Transmembrane protein 195 | Homo | <M><K><N><P><E><A><Q><Q><D><V><S><V><S><Q><G><F><R><M><L><F><Y><T><M><K><P><S><E><T><S><F><Q><T><L><E><E><V><P><D><Y><V><K><K><A><T><P><F><F><I><S><L><M><L><L><E><L><V><V><S><W><I><L><K><G><K><P><P><G><R><L><D><D><A><L><T><S><I><S><A><G><V><L><S><R><L><P><S><L><F><F><R><S><I><E><L><T><S><Y><I><Y><I><W><E><N><Y><R><L><F><N><L><P><W><D><S><P><W><T><W><Y><S><A><F><L><G><V><D><F><G><Y><Y><W><F><H><R><M><A><H><E><V><N><I><M><W><A><G><H><Q><T><H><H><S><S><E><D><Y><N><L><S><T><A><L><R><Q><S><V><L><Q><I><Y><T><S><W><I><F><Y><S><P><L><A><L><F><I><P><P><S><V><Y><A><V><H><L><Q><F><N><L><L><Y><Q><F><W><I><H><T><E><V><I><N><N><L><G><P><L><E><L><I><L><N><T><P><S><H><H><R><V><H><H><G><R><N><R><Y><C><I><D><K><N><Y><A><G><V><L><I><I><W><D><K><I><F><G><T><F><E><A><E><N><E><K><V><V><Y><G><L><T><H><P><I><N><T><F><E><P><I><K><V><Q><F><H><H><L><F><S><I><W><T><T><F><W><A><T><P><G><F><F><N><K><F><S><V><I><F><K><G><P><G><W><G><P><G><K><P><R><L><G><L><S><E><E><I><P><E><V><T><G><K><E><V><P><F><S><S><S><S><S><Q><L><L><K><I><Y><T><V><V><Q><F><A><L><M><L><A><F><Y><E><E><T><F><A><D><T><A><A><L><S><Q><V><T><L><L><L><R><V><C><F><I><I><L><T><L><T><S><I><G><F><L><L><D><Q><R><P><K><A><A><I><M><E><T><L><R><C><L><M><F><L><M><L><Y><R><F><G><H><L><K><P><L><V><P><S><L><S><S><A><F><E><I><V><F><S><I><C><I><A><F><W><G><V><R><S><M><K><Q><L><T><S><H><P><W><K> | Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.<BOP> | Q6ZNB7 |
P13762 | DRB4_HUMAN | MHC class II antigen DRB4 | Homo | <M><V><C><L><K><L><P><G><G><S><C><M><A><A><L><T><V><T><L><T><V><L><S><S><P><L><A><L><A><G><D><T><Q><P><R><F><L><E><Q><A><K><C><E><C><H><F><L><N><G><T><E><R><V><W><N><L><I><R><Y><I><Y><N><Q><E><E><Y><A><R><Y><N><S><D><L><G><E><Y><Q><A><V><T><E><L><G><R><P><D><A><E><Y><W><N><S><Q><K><D><L><L><E><R><R><R><A><E><V><D><T><Y><C><R><Y><N><Y><G><V><V><E><S><F><T><V><Q><R><R><V><Q><P><K><V><T><V><Y><P><S><K><T><Q><P><L><Q><H><H><N><L><L><V><C><S><V><N><G><F><Y><P><G><S><I><E><V><R><W><F><R><N><G><Q><E><E><K><A><G><V><V><S><T><G><L><I><Q><N><G><D><W><T><F><Q><T><L><V><M><L><E><T><V><P><R><S><G><E><V><Y><T><C><Q><V><E><H><P><S><M><M><S><P><L><T><V><Q><W><S><A><R><S><E><S><A><Q><S><K><M><L><S><G><V><G><G><F><V><L><G><L><L><F><L><G><T><G><L><F><I><Y><F><R><N><Q><K><G><H><S><G><L><Q><P><T><G><L><L><S> | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To | P13762 |
Q9UJZ1 | STML2_HUMAN | Paraprotein target 7 | Homo | <M><L><A><R><A><A><R><G><T><G><A><L><L><L><R><G><S><L><L><A><S><G><R><A><P><R><R><A><S><S><G><L><P><R><N><T><V><V><L><F><V><P><Q><Q><E><A><W><V><V><E><R><M><G><R><F><H><R><I><L><E><P><G><L><N><I><L><I><P><V><L><D><R><I><R><Y><V><Q><S><L><K><E><I><V><I><N><V><P><E><Q><S><A><V><T><L><D><N><V><T><L><Q><I><D><G><V><L><Y><L><R><I><M><D><P><Y><K><A><S><Y><G><V><E><D><P><E><Y><A><V><T><Q><L><A><Q><T><T><M><R><S><E><L><G><K><L><S><L><D><K><V><F><R><E><R><E><S><L><N><A><S><I><V><D><A><I><N><Q><A><A><D><C><W><G><I><R><C><L><R><Y><E><I><K><D><I><H><V><P><P><R><V><K><E><S><M><Q><M><Q><V><E><A><E><R><R><K><R><A><T><V><L><E><S><E><G><T><R><E><S><A><I><N><V><A><E><G><K><K><Q><A><Q><I><L><A><S><E><A><E><K><A><E><Q><I><N><Q><A><A><G><E><A><S><A><V><L><A><K><A><K><A><K><A><E><A><I><R><I><L><A><A><A><L><T><Q><H><N><G><D><A><A><A><S><L><T><V><A><E><Q><Y><V><S><A><F><S><K><L><A><K><D><S><N><T><I><L><L><P><S><N><P><G><D><V><T><S><M><V><A><Q><A><M><G><V><Y><G><A><L><T><K><A><P><V><P><G><T><P><D><S><L><S><S><G><S><S><R><D><V><Q><G><T><D><A><S><L><D><E><E><L><D><R><V><K><M><S> | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.<BOP> | Q9UJZ1 |
P52742 | ZN135_HUMAN | Zinc finger protein 78-like 1 | Homo | <M><T><P><G><V><R><V><S><T><D><P><E><Q><V><T><F><E><D><V><V><V><G><F><S><Q><E><E><W><G><Q><L><K><P><A><Q><R><T><L><Y><R><D><V><M><L><D><T><F><R><L><L><V><S><V><G><H><W><L><P><K><P><N><V><I><S><L><L><E><Q><E><A><E><L><W><A><V><E><S><R><L><P><Q><G><V><Y><P><D><L><E><T><R><P><K><V><K><L><S><V><L><K><Q><G><I><S><E><E><I><S><N><S><V><I><L><V><E><R><F><L><W><D><G><L><W><Y><C><R><G><E><D><T><E><G><H><W><E><W><S><C><E><S><L><E><S><L><A><V><P><V><A><F><T><P><V><K><T><P><V><L><E><Q><W><Q><R><N><G><F><G><E><N><I><S><L><N><P><D><L><P><H><Q><P><M><T><P><E><R><Q><S><P><H><T><W><G><T><R><G><K><R><E><K><P><D><L><N><V><L><Q><K><T><C><V><K><E><K><P><Y><K><C><Q><E><C><G><K><A><F><S><H><S><S><A><L><I><E><H><H><R><T><H><T><G><E><R><P><Y><E><C><H><E><C><L><K><G><F><R><N><S><S><A><L><T><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><T><Q><C><G><R><T><F><N><Q><I><A><P><L><I><Q><H><Q><R><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><S><F><S><F><R><S><S><F><S><Q><H><E><R><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><R><Q><S><I><H><L><T><Q><H><L><R><I><H><T><G><E><K><P><Y><Q><C><G><E><C><G><K><A><F><S><H><S><S><S><L><T><K><H><Q><R><I><H><T><G><E><K><P><Y><E><C><H><E><C><G><K><A><F><T><Q><I><T><P><L><I><Q><H><Q><R><T><H><T><G><E><K><P><Y><E><C><G><E><C><G><K><A><F><S><Q><S><T><L><L><T><E><H><R><R><I><H><T><G><E><K><P><Y><G><C><N><E><C><G><K><T><F><S><H><S><S><S><L><S><Q><H><E><R><T><H><T><G><E><K><P><Y><E><C><S><Q><C><G><K><A><F><R><Q><S><T><H><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><D><C><G><K><A><F><S><H><S><S><S><L><T><K><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><Q><C><G><R><A><F><S><Q><L><A><P><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><Q><C><G><R><A><F><S><Q><S><S><L><L><I><E><H><Q><R><I><H><T><K><E><K><P><Y><G><C><N><E><C><G><K><S><F><S><H><S><S><S><L><S><Q><H><E><R><T><H><T><G><E><K><P><Y><E><C><H><D><C><G><K><S><F><R><Q><S><T><H><L><T><Q><H><R><R><I><H><T><G><E><K><P><Y><A><C><R><D><C><G><K><A><F><T><H><S><S><S><L><T><K><H><Q><R><T><H><T><G> | Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.<BOP> | P52742 |
Q9NPH9 | IL26_HUMAN | Protein AK155 | Homo | <M><L><V><N><F><I><L><R><C><G><L><L><L><V><T><L><S><L><A><I><A><K><H><K><Q><S><S><F><T><K><S><C><Y><P><R><G><T><L><S><Q><A><V><D><A><L><Y><I><K><A><A><W><L><K><A><T><I><P><E><D><R><I><K><N><I><R><L><L><K><K><K><T><K><K><Q><F><M><K><N><C><Q><F><Q><E><Q><L><L><S><F><F><M><E><D><V><F><G><Q><L><Q><L><Q><G><C><K><K><I><R><F><V><E><D><F><H><S><L><R><Q><K><L><S><H><C><I><S><C><A><S><S><A><R><E><M><K><S><I><T><R><M><K><R><I><F><Y><R><I><G><N><K><G><I><Y><K><A><I><S><E><L><D><I><L><L><S><W><I><K><K><L><L><E><S><S><Q> | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.<BOP> | Q9NPH9 |
P48454 | PP2BC_HUMAN | Calmodulin-dependent calcineurin A subunit gamma isoform | Homo | <M><S><G><R><R><F><H><L><S><T><T><D><R><V><I><K><A><V><P><F><P><P><T><Q><R><L><T><F><K><E><V><F><E><N><G><K><P><K><V><D><V><L><K><N><H><L><V><K><E><G><R><L><E><E><E><V><A><L><K><I><I><N><D><G><A><A><I><L><R><Q><E><K><T><M><I><E><V><D><A><P><I><T><V><C><G><D><I><H><G><Q><F><F><D><L><M><K><L><F><E><V><G><G><S><P><S><N><T><R><Y><L><F><L><G><D><Y><V><D><R><G><Y><F><S><I><E><C><V><L><Y><L><W><S><L><K><I><N><H><P><K><T><L><F><L><L><R><G><N><H><E><C><R><H><L><T><D><Y><F><T><F><K><Q><E><C><R><I><K><Y><S><E><Q><V><Y><D><A><C><M><E><T><F><D><C><L><P><L><A><A><L><L><N><Q><Q><F><L><C><V><H><G><G><M><S><P><E><I><T><S><L><D><D><I><R><K><L><D><R><F><T><E><P><P><A><F><G><P><V><C><D><L><L><W><S><D><P><S><E><D><Y><G><N><E><K><T><L><E><H><Y><T><H><N><T><V><R><G><C><S><Y><F><Y><S><Y><P><A><V><C><E><F><L><Q><N><N><N><L><L><S><I><I><R><A><H><E><A><Q><D><A><G><Y><R><M><Y><R><K><S><Q><A><T><G><F><P><S><L><I><T><I><F><S><A><P><N><Y><L><D><V><Y><N><N><K><A><A><V><L><K><Y><E><N><N><V><M><N><I><R><Q><F><N><C><S><P><H><P><Y><W><L><P><N><F><M><D><V><F><T><W><S><L><P><F><V><G><E><K><V><T><E><M><L><V><N><V><L><N><I><C><S><D><D><E><L><I><S><D><D><E><A><E><G><S><T><T><V><R><K><E><I><I><R><N><K><I><R><A><I><G><K><M><A><R><V><F><S><I><L><R><Q><E><S><E><S><V><L><T><L><K><G><L><T><P><T><G><T><L><P><L><G><V><L><S><G><G><K><Q><T><I><E><T><A><T><V><E><A><V><E><A><R><E><A><I><R><G><F><S><L><Q><H><K><I><R><S><F><E><E><A><R><G><L><D><R><I><N><E><R><M><P><P><R><K><D><S><I><H><A><G><G><P><M><K><S><V><T><S><A><H><S><H><A><A><H><R><S><D><Q><G><K><K><A><H><S> | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.<BOP> | P48454 |
O75363 | BCAS1_HUMAN | Novel amplified in breast cancer 1 | Homo | <M><G><N><Q><M><S><V><P><Q><R><V><E><D><Q><E><N><E><P><E><A><E><T><Y><Q><D><N><A><S><A><L><N><G><V><P><V><V><V><S><T><H><T><V><Q><H><L><E><E><V><D><L><G><I><S><V><K><T><D><N><V><A><T><S><S><P><E><T><T><E><I><S><A><V><A><D><A><N><G><K><N><L><G><K><E><A><K><P><E><A><P><A><A><K><S><R><F><F><L><M><L><S><R><P><V><P><G><R><T><G><D><Q><A><A><D><S><S><L><G><S><V><K><L><D><V><S><S><N><K><A><P><A><N><K><D><P><S><E><S><W><T><L><P><V><A><A><G><P><G><Q><D><T><D><K><T><P><G><H><A><P><A><Q><D><K><V><L><S><A><A><R><D><P><T><L><L><P><P><E><T><G><G><A><G><G><E><A><P><S><K><P><K><D><S><S><F><F><D><K><F><F><K><L><D><K><G><Q><E><K><V><P><G><D><S><Q><Q><E><A><K><R><A><E><H><Q><D><K><V><D><E><V><P><G><L><S><G><Q><S><D><D><V><P><A><G><K><D><I><V><D><G><K><E><K><E><G><Q><E><L><G><T><A><D><C><S><V><P><G><D><P><E><G><L><E><T><A><K><D><D><S><Q><A><A><A><I><A><E><N><N><N><S><I><M><S><F><F><K><T><L><V><S><P><N><K><A><E><T><K><K><D><P><E><D><T><G><A><E><K><S><P><T><T><S><A><D><L><K><S><D><K><A><N><F><T><S><Q><E><T><Q><G><A><G><K><N><S><K><G><C><N><P><S><G><H><T><Q><S><V><T><T><P><E><P><A><K><E><G><T><K><E><K><S><G><P><T><S><L><P><L><G><K><L><F><W><K><K><S><V><K><E><D><S><V><P><T><G><A><E><E><N><V><V><C><E><S><P><V><E><I><I><K><S><K><E><V><E><S><A><L><Q><T><V><D><L><N><E><G><D><A><A><P><E><P><T><E><A><K><L><K><R><E><E><S><K><P><R><T><S><L><M><A><F><L><R><Q><M><S><V><K><G><D><G><G><I><T><H><S><E><E><I><N><G><K><D><S><S><C><Q><T><S><D><S><T><E><K><T><I><T><P><P><E><P><E><P><T><G><A><P><Q><K><G><K><E><G><S><S><K><D><K><K><S><A><A><E><M><N><K><Q><K><S><N><K><Q><E><A><K><E><P><A><Q><C><T><E><Q><A><T><V><D><T><N><S><L><Q><N><G><D><K><L><Q><K><R><P><E><K><R><Q><Q><S><L><G><G><F><F><K><G><L><G><P><K><R><M><L><D><A><Q><V><Q><T><D><P><V><S><I><G><P><V><G><K><S><K> | Required for myelination.<BOP> | O75363 |
P25490 | TYY1_HUMAN | Yin and yang 1 | Homo | <M><A><S><G><D><T><L><Y><I><A><T><D><G><S><E><M><P><A><E><I><V><E><L><H><E><I><E><V><E><T><I><P><V><E><T><I><E><T><T><V><V><G><E><E><E><E><E><D><D><D><D><E><D><G><G><G><G><D><H><G><G><G><G><G><H><G><H><A><G><H><H><H><H><H><H><H><H><H><H><H><P><P><M><I><A><L><Q><P><L><V><T><D><D><P><T><Q><V><H><H><H><Q><E><V><I><L><V><Q><T><R><E><E><V><V><G><G><D><D><S><D><G><L><R><A><E><D><G><F><E><D><Q><I><L><I><P><V><P><A><P><A><G><G><D><D><D><Y><I><E><Q><T><L><V><T><V><A><A><A><G><K><S><G><G><G><G><S><S><S><S><G><G><G><R><V><K><K><G><G><G><K><K><S><G><K><K><S><Y><L><S><G><G><A><G><A><A><G><G><G><G><A><D><P><G><N><K><K><W><E><Q><K><Q><V><Q><I><K><T><L><E><G><E><F><S><V><T><M><W><S><S><D><E><K><K><D><I><D><H><E><T><V><V><E><E><Q><I><I><G><E><N><S><P><P><D><Y><S><E><Y><M><T><G><K><K><L><P><P><G><G><I><P><G><I><D><L><S><D><P><K><Q><L><A><E><F><A><R><M><K><P><R><K><I><K><E><D><D><A><P><R><T><I><A><C><P><H><K><G><C><T><K><M><F><R><D><N><S><A><M><R><K><H><L><H><T><H><G><P><R><V><H><V><C><A><E><C><G><K><A><F><V><E><S><S><K><L><K><R><H><Q><L><V><H><T><G><E><K><P><F><Q><C><T><F><E><G><C><G><K><R><F><S><L><D><F><N><L><R><T><H><V><R><I><H><T><G><D><R><P><Y><V><C><P><F><D><G><C><N><K><K><F><A><Q><S><T><N><L><K><S><H><I><L><T><H><A><K><A><K><N><N><Q> | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.<BOP> | P25490 |
O95758 | PTBP3_HUMAN | Regulator of differentiation 1 | Homo | <M><D><G><V><V><T><D><L><I><T><V><G><L><K><R><G><S><D><E><L><L><S><S><G><I><I><N><G><P><F><T><M><N><S><S><T><P><S><T><A><N><G><N><D><S><K><K><F><K><R><D><R><P><P><C><S><P><S><R><V><L><H><L><R><K><I><P><C><D><V><T><E><A><E><I><I><S><L><G><L><P><F><G><K><V><T><N><L><L><M><L><K><G><K><S><Q><A><F><L><E><M><A><S><E><E><A><A><V><T><M><V><N><Y><Y><T><P><I><T><P><H><L><R><S><Q><P><V><Y><I><Q><Y><S><N><H><R><E><L><K><T><D><N><L><P><N><Q><A><R><A><Q><A><A><L><Q><A><V><S><A><V><Q><S><G><S><L><A><L><S><G><G><P><S><N><E><G><T><V><L><P><G><Q><S><P><V><L><R><I><I><I><E><N><L><F><Y><P><V><T><L><E><V><L><H><Q><I><F><S><K><F><G><T><V><L><K><I><I><T><F><T><K><N><N><Q><F><Q><A><L><L><Q><Y><A><D><P><V><N><A><H><Y><A><K><M><A><L><D><G><Q><N><I><Y><N><A><C><C><T><L><R><I><D><F><S><K><L><T><S><L><N><V><K><Y><N><N><D><K><S><R><D><F><T><R><L><D><L><P><T><G><D><G><Q><P><S><L><E><P><P><M><A><A><A><F><G><A><P><G><I><I><S><S><P><Y><A><G><A><A><G><F><A><P><A><I><G><F><P><Q><A><T><G><L><S><V><P><A><V><P><G><A><L><G><P><L><T><I><T><S><S><A><V><T><G><R><M><A><I><P><G><A><S><G><I><P><G><N><S><V><L><L><V><T><N><L><N><P><D><L><I><T><P><H><G><L><F><I><L><F><G><V><Y><G><D><V><H><R><V><K><I><M><F><N><K><K><E><N><A><L><V><Q><M><A><D><A><N><Q><A><Q><L><A><M><N><H><L><S><G><Q><R><L><Y><G><K><V><L><R><A><T><L><S><K><H><Q><A><V><Q><L><P><R><E><G><Q><E><D><Q><G><L><T><K><D><F><S><N><S><P><L><H><R><F><K><K><P><G><S><K><N><F><Q><N><I><F><P><P><S><A><T><L><H><L><S><N><I><P><P><S><V><T><V><D><D><L><K><N><L><F><I><E><A><G><C><S><V><K><A><F><K><F><F><Q><K><D><R><K><M><A><L><I><Q><L><G><S><V><E><E><A><I><Q><A><L><I><E><L><H><N><H><D><L><G><E><N><H><H><L><R><V><S><F><S><K><S><T><I> | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).<BOP> | O95758 |
O43513 | MED7_HUMAN | Transcriptional coactivator CRSP33 | Homo | <M><G><E><P><Q><Q><V><S><A><L><P><P><P><P><M><Q><Y><I><K><E><Y><T><D><E><N><I><Q><E><G><L><A><P><K><P><P><P><P><I><K><D><S><Y><M><M><F><G><N><Q><F><Q><C><D><D><L><I><I><R><P><L><E><S><Q><G><I><E><R><L><H><P><M><Q><F><D><H><K><K><E><L><R><K><L><N><M><S><I><L><I><N><F><L><D><L><L><D><I><L><I><R><S><P><G><S><I><K><R><E><E><K><L><E><D><L><K><L><L><F><V><H><V><H><H><L><I><N><E><Y><R><P><H><Q><A><R><E><T><L><R><V><M><M><E><V><Q><K><R><Q><R><L><E><T><A><E><R><F><Q><K><H><L><E><R><V><I><E><M><I><Q><N><C><L><A><S><L><P><D><D><L><P><H><S><E><A><G><M><R><V><K><T><E><P><M><D><A><D><D><S><N><N><C><T><G><Q><N><E><H><Q><R><E><N><S><G><H><R><R><D><Q><I><I><E><K><D><A><A><L><C><V><L><I><D><E><M><N><E><R><P> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP> | O43513 |
P23763 | VAMP1_HUMAN | Synaptobrevin-1 | Homo | <M><S><A><P><A><Q><P><P><A><E><G><T><E><G><T><A><P><G><G><G><P><P><G><P><P><P><N><M><T><S><N><R><R><L><Q><Q><T><Q><A><Q><V><E><E><V><V><D><I><I><R><V><N><V><D><K><V><L><E><R><D><Q><K><L><S><E><L><D><D><R><A><D><A><L><Q><A><G><A><S><Q><F><E><S><S><A><A><K><L><K><R><K><Y><W><W><K><N><C><K><M><M><I><M><L><G><A><I><C><A><I><I><V><V><V><I><V><I><Y><F><F><T> | Involved in the targeting and/or fusion of transport vesicles to their target membrane.<BOP> | P23763 |
Q8NGI4 | OR4DB_HUMAN | Olfactory receptor 4D11 | Homo | <M><E><L><G><N><V><T><R><V><K><E><F><I><F><L><G><L><T><Q><S><Q><D><Q><S><L><V><L><F><L><F><L><C><L><V><Y><M><T><T><L><L><G><N><L><L><I><M><V><T><V><T><C><E><S><R><L><H><T><P><M><Y><F><L><L><R><N><L><A><I><L><D><I><C><F><S><S><T><T><A><P><K><V><L><L><D><L><L><S><K><K><K><T><I><S><Y><T><S><C><M><T><Q><I><F><L><F><H><L><L><G><G><A><D><I><F><S><L><S><V><M><A><F><D><C><Y><M><A><I><S><K><P><L><H><Y><V><T><I><M><S><R><G><Q><C><T><A><L><I><S><A><S><W><M><G><G><F><V><H><S><I><V><Q><I><S><L><L><L><P><L><P><F><C><G><P><N><V><L><D><T><F><Y><C><D><V><P><Q><V><L><K><L><T><C><T><D><T><F><A><L><E><F><L><M><I><S><N><N><G><L><V><T><T><L><W><F><I><F><L><L><V><S><Y><T><V><I><L><M><T><L><R><S><Q><A><G><G><G><R><R><K><A><I><S><T><C><T><S><H><I><T><V><V><T><L><H><F><V><P><C><I><Y><V><Y><A><R><P><F><T><A><L><P><T><E><K><A><I><S><V><T><F><T><V><I><S><P><L><L><N><P><L><I><Y><T><L><R><N><Q><E><M><K><S><A><M><R><R><L><K><R><R><L><V><P><S><E><R><E> | Odorant receptor.<BOP> | Q8NGI4 |
Q9BQY4 | RHXF2_HUMAN | Testis homeobox gene 1 | Homo | <M><E><P><P><D><Q><C><S><Q><Y><M><T><S><L><L><S><P><A><V><D><D><E><K><E><L><Q><D><M><N><A><M><V><L><S><L><T><E><E><V><K><E><E><E><E><D><A><Q><P><E><P><E><Q><G><T><A><A><G><E><K><L><K><S><A><G><A><Q><G><G><E><E><K><D><G><G><G><E><E><K><D><G><G><G><A><G><V><P><G><H><L><W><E><G><D><L><E><G><T><S><G><S><D><G><N><V><E><D><S><D><Q><S><E><K><E><P><G><Q><Q><Y><S><R><P><Q><G><A><V><G><G><L><E><P><G><N><A><Q><Q><P><N><V><H><A><F><T><P><L><Q><L><Q><E><L><E><R><I><F><Q><R><E><Q><F><P><S><E><F><L><R><R><R><L><A><R><S><M><N><V><T><E><L><A><V><Q><I><W><F><E><N><R><R><A><K><W><R><R><H><Q><R><A><L><M><A><R><N><M><L><P><F><M><A><V><G><Q><P><V><M><V><T><A><A><E><A><I><T><A><P><L><F><I><S><G><M><R><D><D><Y><F><W><D><H><S><H><S><S><S><L><C><F><P><M><P><P><F><P><P><P><S><L><P><L><P><L><M><L><L><P><P><M><P><P><A><G><Q><A><E><F><G><P><F><P><F><V><I><V><P><S><F><T><F><P><N><V> | Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.<BOP> | Q9BQY4 |
Q92611 | EDEM1_HUMAN | ER degradation-enhancing alpha-mannosidase-like protein 1 | Homo | <M><Q><W><R><A><L><V><L><G><L><V><L><L><R><L><G><L><H><G><V><L><W><L><V><F><G><L><G><P><S><M><G><F><Y><Q><R><F><P><L><S><F><G><F><Q><R><L><R><S><P><D><G><P><A><S><P><T><S><G><P><V><G><R><P><G><G><V><S><G><P><S><W><L><Q><P><P><G><T><G><A><A><Q><S><P><R><K><A><P><R><R><P><G><P><G><M><C><G><P><A><N><W><G><Y><V><L><G><G><R><G><R><G><P><D><E><Y><E><K><R><Y><S><G><A><F><P><P><Q><L><R><A><Q><M><R><D><L><A><R><G><M><F><V><F><G><Y><D><N><Y><M><A><H><A><F><P><Q><D><E><L><N><P><I><H><C><R><G><R><G><P><D><R><G><D><P><S><N><L><N><I><N><D><V><L><G><N><Y><S><L><T><L><V><D><A><L><D><T><L><A><I><M><G><N><S><S><E><F><Q><K><A><V><K><L><V><I><N><T><V><S><F><D><K><D><S><T><V><Q><V><F><E><A><T><I><R><V><L><G><S><L><L><S><A><H><R><I><I><T><D><S><K><Q><P><F><G><D><M><T><I><K><D><Y><D><N><E><L><L><Y><M><A><H><D><L><A><V><R><L><L><P><A><F><E><N><T><K><T><G><I><P><Y><P><R><V><N><L><K><T><G><V><P><P><D><T><N><N><E><T><C><T><A><G><A><G><S><L><L><V><E><F><G><I><L><S><R><L><L><G><D><S><T><F><E><W><V><A><R><R><A><V><K><A><L><W><N><L><R><S><N><D><T><G><L><L><G><N><V><V><N><I><Q><T><G><H><W><V><G><K><Q><S><G><L><G><A><G><L><D><S><F><Y><E><Y><L><L><K><S><Y><I><L><F><G><E><K><E><D><L><E><M><F><N><A><A><Y><Q><S><I><Q><N><Y><L><R><R><G><R><E><A><C><N><E><G><E><G><D><P><P><L><Y><V><N><V><N><M><F><S><G><Q><L><M><N><T><W><I><D><S><L><Q><A><F><F><P><G><L><Q><V><L><I><G><D><V><E><D><A><I><C><L><H><A><F><Y><Y><A><I><W><K><R><Y><G><A><L><P><E><R><Y><N><W><Q><L><Q><A><P><D><V><L><F><Y><P><L><R><P><E><L><V><E><S><T><Y><L><L><Y><Q><A><T><K><N><P><F><Y><L><H><V><G><M><D><I><L><Q><S><L><E><K><Y><T><K><V><K><C><G><Y><A><T><L><H><H><V><I><D><K><S><T><E><D><R><M><E><S><F><F><L><S><E><T><C><K><Y><L><Y><L><L><F><D><E><D><N><P><V><H><K><S><G><T><R><Y><M><F><T><T><E><G><H><I><V><S><V><D><E><H><L><R><E><L><P><W><K><E><F><F><S><E><E><G><G><Q><D><Q><G><G><K><S><V><H><R><P><K><P><H><E><L><K><V><I><N><S><S><S><N><C><N><R><V><P><D><E><R><R><Y><S><L><P><L><K><S><I><Y><M><R><Q><I><D><Q><M><V><G><L><I> | Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.<BOP> | Q92611 |
Q9BXA5 | SUCR1_HUMAN | P2Y purinoceptor 1-like | Homo | <M><L><G><I><M><A><W><N><A><T><C><K><N><W><L><A><A><E><A><A><L><E><K><Y><Y><L><S><I><F><Y><G><I><E><F><V><V><G><V><L><G><N><T><I><V><V><Y><G><Y><I><F><S><L><K><N><W><N><S><S><N><I><Y><L><F><N><L><S><V><S><D><L><A><F><L><C><T><L><P><M><L><I><R><S><Y><A><N><G><N><W><I><Y><G><D><V><L><C><I><S><N><R><Y><V><L><H><A><N><L><Y><T><S><I><L><F><L><T><F><I><S><I><D><R><Y><L><I><I><K><Y><P><F><R><E><H><L><L><Q><K><K><E><F><A><I><L><I><S><L><A><I><W><V><L><V><T><L><E><L><L><P><I><L><P><L><I><N><P><V><I><T><D><N><G><T><T><C><N><D><F><A><S><S><G><D><P><N><Y><N><L><I><Y><S><M><C><L><T><L><L><G><F><L><I><P><L><F><V><M><C><F><F><Y><Y><K><I><A><L><F><L><K><Q><R><N><R><Q><V><A><T><A><L><P><L><E><K><P><L><N><L><V><I><M><A><V><V><I><F><S><V><L><F><T><P><Y><H><V><M><R><N><V><R><I><A><S><R><L><G><S><W><K><Q><Y><Q><C><T><Q><V><V><I><N><S><F><Y><I><V><T><R><P><L><A><F><L><N><S><V><I><N><P><V><F><Y><F><L><L><G><D><H><F><R><D><M><L><M><N><Q><L><R><H><N><F><K><S><L><T><S><F><S><R><W><A><H><E><L><L><L><S><F><R><E><K> | Receptor for succinate.<BOP> | Q9BXA5 |
Q3KP22 | MAJIN_HUMAN | Membrane-anchored junction protein | Homo | <M><S><L><K><P><F><T><Y><P><F><P><E><T><R><F><L><H><A><G><P><N><V><Y><K><F><K><I><R><Y><G><K><S><I><R><G><E><E><I><E><N><K><E><V><I><T><Q><E><L><E><V><P><V><E><K><K><A><V><G><A><V><M><R><K><R><K><H><M><D><E><P><S><S><P><S><R><P><G><L><D><R><A><K><I><G><T><S><S><Q><G><P><S><K><K><K><P><P><V><E><T><R><R><N><R><E><R><K><T><Q><Q><G><L><Q><E><T><L><A><S><D><I><T><D><V><Q><K><Q><D><S><E><W><G><H><S><L><P><G><R><I><V><P><P><L><Q><H><N><S><P><P><P><K><E><R><A><A><T><G><F><F><G><F><L><S><S><L><F><P><F><R><Y><F><F><R><K><S><S><H><S> | Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.<BOP> | Q3KP22 |
O00469 | PLOD2_HUMAN | Lysyl hydroxylase 2 | Homo | <M><G><G><C><T><V><K><P><Q><L><L><L><L><A><L><V><L><H><P><W><N><P><C><L><G><A><D><S><E><K><P><S><S><I><P><T><D><K><L><L><V><I><T><V><A><T><K><E><S><D><G><F><H><R><F><M><Q><S><A><K><Y><F><N><Y><T><V><K><V><L><G><Q><G><E><E><W><R><G><G><D><G><I><N><S><I><G><G><G><Q><K><V><R><L><M><K><E><V><M><E><H><Y><A><D><Q><D><D><L><V><V><M><F><T><E><C><F><D><V><I><F><A><G><G><P><E><E><V><L><K><K><F><Q><K><A><N><H><K><V><V><F><A><A><D><G><I><L><W><P><D><K><R><L><A><D><K><Y><P><V><V><H><I><G><K><R><Y><L><N><S><G><G><F><I><G><Y><A><P><Y><V><N><R><I><V><Q><Q><W><N><L><Q><D><N><D><D><D><Q><L><F><Y><T><K><V><Y><I><D><P><L><K><R><E><A><I><N><I><T><L><D><H><K><C><K><I><F><Q><T><L><N><G><A><V><D><E><V><V><L><K><F><E><N><G><K><A><R><A><K><N><T><F><Y><E><T><L><P><V><A><I><N><G><N><G><P><T><K><I><L><L><N><Y><F><G><N><Y><V><P><N><S><W><T><Q><D><N><G><C><T><L><C><E><F><D><T><V><D><L><S><A><V><D><V><H><P><N><V><S><I><G><V><F><I><E><Q><P><T><P><F><L><P><R><F><L><D><I><L><L><T><L><D><Y><P><K><E><A><L><K><L><F><I><H><N><K><E><V><Y><H><E><K><D><I><K><V><F><F><D><K><A><K><H><E><I><K><T><I><K><I><V><G><P><E><E><N><L><S><Q><A><E><A><R><N><M><G><M><D><F><C><R><Q><D><E><K><C><D><Y><Y><F><S><V><D><A><D><V><V><L><T><N><P><R><T><L><K><I><L><I><E><Q><N><R><K><I><I><A><P><L><V><T><R><H><G><K><L><W><S><N><F><W><G><A><L><S><P><D><G><Y><Y><A><R><S><E><D><Y><V><D><I><V><Q><G><N><R><V><G><V><W><N><V><P><Y><M><A><N><V><Y><L><I><K><G><K><T><L><R><S><E><M><N><E><R><N><Y><F><V><R><D><K><L><D><P><D><M><A><L><C><R><N><A><R><E><M><G><V><F><M><Y><I><S><N><R><H><E><F><G><R><L><L><S><T><A><N><Y><N><T><S><H><Y><N><N><D><L><W><Q><I><F><E><N><P><V><D><W><K><E><K><Y><I><N><R><D><Y><S><K><I><F><T><E><N><I><V><E><Q><P><C><P><D><V><F><W><F><P><I><F><S><E><K><A><C><D><E><L><V><E><E><M><E><H><Y><G><K><W><S><G><G><K><H><H><D><S><R><I><S><G><G><Y><E><N><V><P><T><D><D><I><H><M><K><Q><V><D><L><E><N><V><W><L><H><F><I><R><E><F><I><A><P><V><T><L><K><V><F><A><G><Y><Y><T><K><G><F><A><L><L><N><F><V><V><K><Y><S><P><E><R><Q><R><S><L><R><P><H><H><D><A><S><T><F><T><I><N><I><A><L><N><N><V><G><E><D><F><Q><G><G><G><C><K><F><L><R><Y><N><C><S><I><E><S><P><R><K><G><W><S><F><M><H><P><G><R><L><T><H><L><H><E><G><L><P><V><K><N><G><T><R><Y><I><A><V><S><F><I><D><P> | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.<BOP> | O00469 |
P0DPD7 | EFMT4_HUMAN | EEF1A lysine methyltransferase 4 | Homo | <M><A><S><P><G><A><G><R><A><P><P><E><L><P><E><R><N><C><G><Y><R><E><V><E><Y><W><D><Q><R><Y><Q><G><A><A><D><S><A><P><Y><D><W><F><G><D><F><S><S><F><R><A><L><L><E><P><E><L><R><P><E><D><R><I><L><V><L><G><C><G><N><S><A><L><S><Y><E><L><F><L><G><G><F><P><N><V><T><S><V><D><Y><S><S><V><V><V><A><A><M><Q><A><R><H><A><H><V><P><Q><L><R><W><E><T><M><D><V><R><K><L><D><F><P><S><A><S><F><D><V><V><L><E><K><G><T><L><D><A><L><L><A><G><E><R><D><P><W><T><V><S><S><E><G><V><H><T><V><D><Q><V><L><S><E><V><S><R><V><L><V><P><G><G><R><F><I><S><M><T><S><A><A><P><H><F><R><T><R><H><Y><A><Q><A><Y><Y><G><W><S><L><R><H><A><T><Y><G><S><G><F><H><F><H><L><Y><L><M><H><K><G><G><K><L><S><V><A><Q><L><A><L><G><A><Q><I><L><S><P><P><R><P><P><T><S><P><C><F><L><Q><D><S><D><H><E><D><F><L><S><A><I><Q><L> | Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).<BOP> | P0DPD7 |
Q7L2H7 | EIF3M_HUMAN | PCI domain-containing protein 1 | Homo | <M><S><V><P><A><F><I><D><I><S><E><E><D><Q><A><A><E><L><R><A><Y><L><K><S><K><G><A><E><I><S><E><E><N><S><E><G><G><L><H><V><D><L><A><Q><I><I><E><A><C><D><V><C><L><K><E><D><D><K><D><V><E><S><V><M><N><S><V><V><S><L><L><L><I><L><E><P><D><K><Q><E><A><L><I><E><S><L><C><E><K><L><V><K><F><R><E><G><E><R><P><S><L><R><L><Q><L><L><S><N><L><F><H><G><M><D><K><N><T><P><V><R><Y><T><V><Y><C><S><L><I><K><V><A><A><S><C><G><A><I><Q><Y><I><P><T><E><L><D><Q><V><R><K><W><I><S><D><W><N><L><T><T><E><K><K><H><T><L><L><R><L><L><Y><E><A><L><V><D><C><K><K><S><D><A><A><S><K><V><M><V><E><L><L><G><S><Y><T><E><D><N><A><S><Q><A><R><V><D><A><H><R><C><I><V><R><A><L><K><D><P><N><A><F><L><F><D><H><L><L><T><L><K><P><V><K><F><L><E><G><E><L><I><H><D><L><L><T><I><F><V><S><A><K><L><A><S><Y><V><K><F><Y><Q><N><N><K><D><F><I><D><S><L><G><L><L><H><E><Q><N><M><A><K><M><R><L><L><T><F><M><G><M><A><V><E><N><K><E><I><S><F><D><T><M><Q><Q><E><L><Q><I><G><A><D><D><V><E><A><F><V><I><D><A><V><R><T><K><M><V><Y><C><K><I><D><Q><T><Q><R><K><V><V><V><S><H><S><T><H><R><T><F><G><K><Q><Q><W><Q><Q><L><Y><D><T><L><N><A><W><K><Q><N><L><N><K><V><K><N><S><L><L><S><L><S><D><T> | (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).<BOP> | Q7L2H7 |
P07451 | CAH3_HUMAN | Carbonic anhydrase III | Homo | <M><A><K><E><W><G><Y><A><S><H><N><G><P><D><H><W><H><E><L><F><P><N><A><K><G><E><N><Q><S><P><V><E><L><H><T><K><D><I><R><H><D><P><S><L><Q><P><W><S><V><S><Y><D><G><G><S><A><K><T><I><L><N><N><G><K><T><C><R><V><V><F><D><D><T><Y><D><R><S><M><L><R><G><G><P><L><P><G><P><Y><R><L><R><Q><F><H><L><H><W><G><S><S><D><D><H><G><S><E><H><T><V><D><G><V><K><Y><A><A><E><L><H><L><V><H><W><N><P><K><Y><N><T><F><K><E><A><L><K><Q><R><D><G><I><A><V><I><G><I><F><L><K><I><G><H><E><N><G><E><F><Q><I><F><L><D><A><L><D><K><I><K><T><K><G><K><E><A><P><F><T><K><F><D><P><S><C><L><F><P><A><C><R><D><Y><W><T><Y><Q><G><S><F><T><T><P><P><C><E><E><C><I><V><W><L><L><L><K><E><P><M><T><V><S><S><D><Q><M><A><K><L><R><S><L><L><S><S><A><E><N><E><P><P><V><P><L><V><S><N><W><R><P><P><Q><P><I><N><N><R><V><V><R><A><S><F><K> | Reversible hydration of carbon dioxide.<BOP> | P07451 |
Q04837 | SSBP_HUMAN | PWP1-interacting protein 17 | Homo | <M><F><R><R><P><V><L><Q><V><L><R><Q><F><V><R><H><E><S><E><T><T><T><S><L><V><L><E><R><S><L><N><R><V><H><L><L><G><R><V><G><Q><D><P><V><L><R><Q><V><E><G><K><N><P><V><T><I><F><S><L><A><T><N><E><M><W><R><S><G><D><S><E><V><Y><Q><L><G><D><V><S><Q><K><T><T><W><H><R><I><S><V><F><R><P><G><L><R><D><V><A><Y><Q><Y><V><K><K><G><S><R><I><Y><L><E><G><K><I><D><Y><G><E><Y><M><D><K><N><N><V><R><R><Q><A><T><T><I><I><A><D><N><I><I><F><L><S><D><Q><T><K><E><K><E> | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) . In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork . Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity . In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK . May also function in mtDNA repair .<BOP> | Q04837 |
O95935 | TBX18_HUMAN | T-box transcription factor TBX18 | Homo | <M><A><E><K><R><R><G><S><P><C><S><M><L><S><L><K><A><H><A><F><S><V><E><A><L><I><G><A><E><K><Q><Q><Q><L><Q><K><K><R><R><K><L><G><A><E><E><A><A><G><A><V><D><D><G><G><C><S><R><G><G><G><A><G><E><K><G><S><S><E><G><D><E><G><A><A><L><P><P><P><A><G><A><T><S><G><P><A><R><S><G><A><D><L><E><R><G><A><A><G><G><C><E><D><G><F><Q><Q><G><A><S><P><L><A><S><P><G><G><S><P><K><G><S><P><A><R><S><L><A><R><P><G><T><P><L><P><S><P><Q><A><P><R><V><D><L><Q><G><A><E><L><W><K><R><F><H><E><I><G><T><E><M><I><I><T><K><A><G><R><R><M><F><P><A><M><R><V><K><I><S><G><L><D><P><H><Q><Q><Y><Y><I><A><M><D><I><V><P><V><D><N><K><R><Y><R><Y><V><Y><H><S><S><K><W><M><V><A><G><N><A><D><S><P><V><P><P><R><V><Y><I><H><P><D><S><P><A><S><G><E><T><W><M><R><Q><V><I><S><F><D><K><L><K><L><T><N><N><E><L><D><D><Q><G><H><I><I><L><H><S><M><H><K><Y><Q><P><R><V><H><V><I><R><K><D><C><G><D><D><L><S><P><I><K><P><V><P><S><G><E><G><V><K><A><F><S><F><P><E><T><V><F><T><T><V><T><A><Y><Q><N><Q><Q><I><T><R><L><K><I><D><R><N><P><F><A><K><G><F><R><D><S><G><R><N><R><M><G><L><E><A><L><V><E><S><Y><A><F><W><R><P><S><L><R><T><L><T><F><E><D><I><P><G><I><P><K><Q><G><N><A><S><S><S><T><L><L><Q><G><T><G><N><G><V><P><A><T><H><P><H><L><L><S><G><S><S><C><S><S><P><A><F><H><L><G><P><N><T><S><Q><L><C><S><L><A><P><A><D><Y><S><A><C><A><R><S><G><L><T><L><N><R><Y><S><T><S><L><A><E><T><Y><N><R><L><T><N><Q><A><G><E><T><F><A><P><P><R><T><P><S><Y><V><G><V><S><S><S><T><S><V><N><M><S><M><G><G><T><D><G><D><T><F><S><C><P><Q><T><S><L><S><M><Q><I><S><G><M><S><P><Q><L><Q><Y><I><M><P><S><P><S><S><N><A><F><A><T><N><Q><T><H><Q><G><S><Y><N><T><F><R><L><H><S><P><C><A><L><Y><G><Y><N><F><S><T><S><P><K><L><A><A><S><P><E><K><I><V><S><S><Q><G><S><F><L><G><S><S><P><S><G><T><M><T><D><R><Q><M><L><P><P><V><E><G><V><H><L><L><S><S><G><G><Q><Q><S><F><F><D><S><R><T><L><G><S><L><T><L><S><S><S><Q><V><S><A><H><M><V> | Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.<BOP> | O95935 |
B2RV13 | CF97D_HUMAN | CFAP97 domain-containing protein 1 | Homo | <M><N><N><S><L><D><Y><L><A><Y><P><V><I><V><S><N><H><R><Q><S><T><T><F><R><K><K><L><D><F><G><H><Y><V><S><H><K><N><R><I><Q><I><A><K><P><T><V><D><T><K><P><P><V><A><H><T><N><H><I><L><K><L><S><K><L><Q><G><E><Q><K><K><I><N><K><I><E><Y><E><N><K><Q><L><C><Q><K><I><A><N><A><H><R><G><P><A><K><V><D><C><W><N><E><Y><F><S><K><S><L><N><R><E><T><R><N><R><E><L><V><R><I><T><M><E><N><Q><G><I><L><K><R><L><V><D><R><K><P><H><Y><D><R><R><A><S><E><I><D><W><Q><N><S><R><R><Y><I><R><N><T><T><R><Y><L><L><S><Q><N><E> | Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization.<BOP> | B2RV13 |
Q9H1E3 | NUCKS_HUMAN | P1 | Homo | <M><S><R><P><V><R><N><R><K><V><V><D><Y><S><Q><F><Q><E><S><D><D><A><D><E><D><Y><G><R><D><S><G><P><P><T><K><K><I><R><S><S><P><R><E><A><K><N><K><R><R><S><G><K><N><S><Q><E><D><S><E><D><S><E><D><K><D><V><K><T><K><K><D><D><S><H><S><A><E><D><S><E><D><E><K><E><D><H><K><N><V><R><Q><Q><R><Q><A><A><S><K><A><A><S><K><Q><R><E><M><L><M><E><D><V><G><S><E><E><E><Q><E><E><E><D><E><A><P><F><Q><E><K><D><S><G><S><D><E><D><F><L><M><E><D><D><D><D><S><D><Y><G><S><S><K><K><K><N><K><K><M><V><K><K><S><K><P><E><R><K><E><K><K><M><P><K><P><R><L><K><A><T><V><T><P><S><P><V><K><G><K><G><K><V><G><R><P><T><A><S><K><A><S><K><E><K><T><P><S><P><K><E><E><D><E><E><P><E><S><P><P><E><K><K><T><S><T><S><P><P><P><E><K><S><G><D><E><G><S><E><D><E><A><P><S><G><E><D> | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) . Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 .<BOP> | Q9H1E3 |
Q92765 | SFRP3_HUMAN | FrzB-1 | Homo | <M><V><C><G><S><P><G><G><M><L><L><L><R><A><G><L><L><A><L><A><A><L><C><L><L><R><V><P><G><A><R><A><A><A><C><E><P><V><R><I><P><L><C><K><S><L><P><W><N><M><T><K><M><P><N><H><L><H><H><S><T><Q><A><N><A><I><L><A><I><E><Q><F><E><G><L><L><G><T><H><C><S><P><D><L><L><F><F><L><C><A><M><Y><A><P><I><C><T><I><D><F><Q><H><E><P><I><K><P><C><K><S><V><C><E><R><A><R><Q><G><C><E><P><I><L><I><K><Y><R><H><S><W><P><E><N><L><A><C><E><E><L><P><V><Y><D><R><G><V><C><I><S><P><E><A><I><V><T><A><D><G><A><D><F><P><M><D><S><S><N><G><N><C><R><G><A><S><S><E><R><C><K><C><K><P><I><R><A><T><Q><K><T><Y><F><R><N><N><Y><N><Y><V><I><R><A><K><V><K><E><I><K><T><K><C><H><D><V><T><A><V><V><E><V><K><E><I><L><K><S><S><L><V><N><I><P><R><D><T><V><N><L><Y><T><S><S><G><C><L><C><P><P><L><N><V><N><E><E><Y><I><I><M><G><Y><E><D><E><E><R><S><R><L><L><L><V><E><G><S><I><A><E><K><W><K><D><R><L><G><K><K><V><K><R><W><D><M><K><L><R><H><L><G><L><S><K><S><D><S><S><N><S><D><S><T><Q><S><Q><K><S><G><R><N><S><N><P><R><Q><A><R><N> | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.<BOP> | Q92765 |
P07737 | PROF1_HUMAN | Profilin I | Homo | <M><A><G><W><N><A><Y><I><D><N><L><M><A><D><G><T><C><Q><D><A><A><I><V><G><Y><K><D><S><P><S><V><W><A><A><V><P><G><K><T><F><V><N><I><T><P><A><E><V><G><V><L><V><G><K><D><R><S><S><F><Y><V><N><G><L><T><L><G><G><Q><K><C><S><V><I><R><D><S><L><L><Q><D><G><E><F><S><M><D><L><R><T><K><S><T><G><G><A><P><T><F><N><V><T><V><T><K><T><D><K><T><L><V><L><L><M><G><K><E><G><V><H><G><G><L><I><N><K><K><C><Y><E><M><A><S><H><L><R><R><S><Q><Y> | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.<BOP> | P07737 |
A0A0C4DH42 | HV366_HUMAN | Immunoglobulin heavy variable 3-66 | null | <M><E><F><G><L><S><W><V><F><L><V><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><I><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><V><S><S><N><Y><M><S><W><V><R><Q><A><P><G><K><G><L><E><W><V><S><V><I><Y><S><C><G><S><T><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><R> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0C4DH42 |
Q8WZ55 | BSND_HUMAN | Barttin | Homo | <M><A><D><E><K><T><F><R><I><G><F><I><V><L><G><L><F><L><L><A><L><G><T><F><L><M><S><H><D><R><P><Q><V><Y><G><T><F><Y><A><M><G><S><V><M><V><I><G><G><I><I><W><S><M><C><Q><C><Y><P><K><I><T><F><V><P><A><D><S><D><F><Q><G><I><L><S><P><K><A><M><G><L><L><E><N><G><L><A><A><E><M><K><S><P><S><P><Q><P><P><Y><V><R><L><W><E><E><A><A><Y><D><Q><S><L><P><D><F><S><H><I><Q><M><K><V><M><S><Y><S><E><D><H><R><S><L><L><A><P><E><M><G><Q><P><K><L><G><T><S><D><G><G><E><G><G><P><G><D><V><Q><A><W><M><E><A><A><V><V><I><H><K><G><S><D><E><S><E><G><E><R><R><L><T><Q><S><W><P><G><P><L><A><C><P><Q><G><P><A><P><L><A><S><F><Q><D><D><L><D><M><D><S><S><E><G><S><S><P><N><A><S><P><H><D><R><E><E><A><C><S><P><Q><Q><E><P><Q><G><C><R><C><P><L><D><R><F><Q><D><F><A><L><I><D><A><P><T><L><E><D><E><P><Q><E><G><Q><Q><W><E><I><A><L><P><N><N><W><Q><R><Y><P><R><T><K><V><E><E><K><E><A><S><D><T><G><G><E><E><P><E><K><E><E><E><D><L><Y><Y><G><L><P><D><G><A><G><D><L><L><P><D><K><E><L><G><F><E><P><D><T><Q><G> | Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.<BOP> | Q8WZ55 |
C9JSJ3 | MEIOS_HUMAN | Basic helix-loop-helix and HMG box domain-containing protein 1 | Homo | <M><F><G><S><S><R><Y><L><G><S><S><E><Q><P><R><A><N><S><L><G><P><S><D><R><T><L><V><L><C><S><L><V><E><G><E><D><K><V><N><P><S><E><P><H><G><L><R><M><E><E><K><W><L><L><K><G><K><L><R><N><Q><R><N><Q><N><K><L><L><S><P><N><K><K><Q><R><K><N><H><T><S><K><L><Q><E><L><A><L><L><L><P><I><A><L><K><T><G><T><K><K><L><T><K><K><E><I><L><V><H><V><L><Q><Y><I><Q><Y><L><Q><R><N><I><D><A><A><K><A><L><F><K><C><H><I><T><T><G><E><G><G><L><A><G><L><G><Q><K><P><A><W><G><P><A><R><R><R><R><H><S><T><P><S><S><S><P><S><S><Q><K><S><C><L><Q><G><A><C><Q><K><P><R><K><K><K><L><T><Q><A><S><E><S><Q><T><R><T><P><K><P><R><R><S><L><A><L><N><K><P><E><K><L><V><A><P><S><P><D><Q><K><G><S><G><T><G><G><T><T><T><P><P><R><C><P><D><S><C><G><H><P><R><P><A><S><S><S><P><P><G><D><R><K><G><G><Q><S><Q><L><T><L><L><D><L><A><E><D><T><I><H><C><D><I><S><S><C><W><C><Q><G><S><V><Q><D><D><A><P><F><P><A><L><L><A><Q><E><D><V><A><R><I><H><F><L><N><K><T><Q><P><H><P><R><Q><K><L><V><F><Y><D><S><S><E><D><V><D><K><G><S><L><D><A><D><P><W><L><P><A><W><T><P><E><N><S><P><Q><G><S><P><L><F><L><G><P><P><Q><I><D><V><W><S><G><T><G><H><P><S><E><I><L><G><L><S><P><S><L><F><S><S><P><G><K><L><L><P><D><E><I><L><E><D><D><M><E><Y><L><T><Q><A><A><F><F><E><E><V><C><L><D><L><E><S><S><P><S><A><Y><T><Q><E><A><P><Q><E><K><D><T><A><S><K><A><P><K><D><P><P><E><S><H><S><L><H><R><S><S><V><S><L><D><H><C><Y><L><S><L><S><G><N><S><K><A><P><S><S><S><S><S><S><S><S><S><S><S><S><S><E><D><S><D><S><E><P><L><W><K><Q><R><E><D><M><Q><A><N><P><V><G><T><P><G><S><S><E><E><D><E><D><T><T><W><T><P><T><R><L><A><S><P><L><L><A><A><E><K><K><A><T><K><G><Q><V><A><R><A><P><V><K><P><K><E><K><K><K><G><P><C><P><P><Q><M><K><K><K><C><V><N><G><F><I><M><F><C><R><M><N><R><K><Q><Y><I><R><S><C><P><G><T><A><S><T><A><A><T><K><E><L><A><Q><L><W><R><V><M><T><Q><Q><E><R><R><P><Y><C><T><K><A><R><R><F><S><R><Q><H><N><R><I><V><K><Q><D><G><S><S><S><E><A><E><D><W><E><T><P><K><P><F><Y><Q><L><L><A><E><K><A><L><P><L><P><P><H><L><Q> | Gatekeeper of meiotic initiation in both male and female germ cells. In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision.<BOP> | C9JSJ3 |
A0A0C4DH36 | HV338_HUMAN | Probable non-functional immunoglobulin heavy variable 3-38 | Homo | <M><Q><F><V><L><S><W><V><F><L><V><G><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><R><G><S><L><R><L><S><C><A><A><S><G><F><T><V><S><S><N><E><M><S><W><I><R><Q><A><P><G><K><G><L><E><W><V><S><S><I><S><G><G><S><T><Y><Y><A><D><S><R><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><N><L><R><A><E><G><T><A><V><Y><Y><C><A><R><Y> | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection | A0A0C4DH36 |
Q8N0X4 | CLYBL_HUMAN | Malate synthase | Homo | <M><A><L><R><L><L><R><R><A><A><R><G><A><A><A><A><A><L><L><R><L><K><A><S><L><A><A><D><I><P><R><L><G><Y><S><S><S><S><H><H><K><Y><I><P><R><R><A><V><L><Y><V><P><G><N><D><E><K><K><I><K><K><I><P><S><L><N><V><D><C><A><V><L><D><C><E><D><G><V><A><A><N><K><K><N><E><A><R><L><R><I><V><K><T><L><E><D><I><D><L><G><P><T><E><K><C><V><R><V><N><S><V><S><S><G><L><A><E><E><D><L><E><T><L><L><Q><S><R><V><L><P><S><S><L><M><L><P><K><V><E><S><P><E><E><I><Q><W><F><A><D><K><F><S><F><H><L><K><G><R><K><L><E><Q><P><M><N><L><I><P><F><V><E><T><A><M><G><L><L><N><F><K><A><V><C><E><E><T><L><K><V><G><P><Q><V><G><L><F><L><D><A><V><V><F><G><G><E><D><F><R><A><S><I><G><A><T><S><S><K><E><T><L><D><I><L><Y><A><R><Q><K><I><V><V><I><A><K><A><F><G><L><Q><A><I><D><L><V><Y><I><D><F><R><D><G><A><G><L><L><R><Q><S><R><E><G><A><A><M><G><F><T><G><K><Q><V><I><H><P><N><Q><I><A><V><V><Q><E><Q><F><S><P><S><P><E><K><I><K><W><A><E><E><L><I><A><A><F><K><E><H><Q><Q><L><G><K><G><A><F><T><F><Q><G><S><M><I><D><M><P><L><L><K><Q><A><Q><N><T><V><T><L><A><T><S><I><K><E><K> | Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism . Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway . The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite . Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate . Also displays malyl-CoA thioesterase activity . Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate . Also has very weak citramalate synthase activity in vitro .<BOP> | Q8N0X4 |
Q96IZ6 | MET2A_HUMAN | Methyltransferase-like protein 2A | Homo | <M><A><G><S><Y><P><E><G><A><P><A><V><L><A><D><K><R><Q><Q><F><G><S><R><F><L><R><D><P><A><R><V><F><H><H><N><A><W><D><N><V><E><W><S><E><E><Q><A><A><A><A><E><R><K><V><Q><E><N><S><I><Q><R><V><C><Q><E><K><Q><V><D><Y><E><I><N><A><H><K><Y><W><N><D><F><Y><K><I><H><E><N><G><F><F><K><D><R><H><W><L><F><T><E><F><P><E><L><A><P><S><Q><N><Q><N><H><L><K><D><W><F><L><E><N><K><S><E><V><P><E><C><R><N><N><E><D><G><P><G><L><I><M><E><E><Q><H><K><C><S><S><K><S><L><E><H><K><T><Q><T><L><P><V><E><E><N><V><T><Q><K><I><S><D><L><E><I><C><A><D><E><F><P><G><S><S><A><T><Y><R><I><L><E><V><G><C><G><V><G><N><T><V><F><P><I><L><Q><T><N><N><D><P><G><L><F><V><Y><C><C><D><F><S><S><T><A><I><E><L><V><Q><T><N><S><E><Y><D><P><S><R><C><F><A><F><V><H><D><L><C><D><E><E><K><S><Y><P><V><P><K><G><S><L><D><I><I><I><L><I><F><V><L><S><A><I><V><P><D><K><M><Q><K><A><I><N><R><L><S><R><L><L><K><P><G><G><M><M><L><L><R><D><Y><G><R><Y><D><M><A><Q><L><R><F><K><K><G><Q><C><L><S><G><N><F><Y><V><R><G><D><G><T><R><V><Y><F><F><T><Q><E><E><L><D><T><L><F><T><T><A><G><L><E><K><V><Q><N><L><V><D><R><R><L><Q><V><N><R><G><K><Q><L><T><M><Y><R><V><W><I><Q><C><K><Y><C><K><P><L><L><S><S><T><S> | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) . N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite .<BOP> | Q96IZ6 |
Q9P0J0 | NDUAD_HUMAN | NADH-ubiquinone oxidoreductase B16.6 subunit | Homo | <M><A><A><S><K><V><K><Q><D><M><P><P><P><G><G><Y><G><P><I><D><Y><K><R><N><L><P><R><R><G><L><S><G><Y><S><M><L><A><I><G><I><G><T><L><I><Y><G><H><W><S><I><M><K><W><N><R><E><R><R><R><L><Q><I><E><D><F><E><A><R><I><A><L><L><P><L><L><Q><A><E><T><D><R><R><T><L><Q><M><L><R><E><N><L><E><E><E><A><I><I><M><K><D><V><P><D><W><K><V><G><E><S><V><F><H><T><T><R><W><V><P><P><L><I><G><E><L><Y><G><L><R><T><T><E><E><A><L><H><A><S><H><G><F><M><W><Y><T> | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis . Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone . Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes .<BOP> | Q9P0J0 |
Q6P5S2 | LEG1H_HUMAN | Protein LEG1 homolog | Homo | <M><A><F><L><P><S><W><V><C><V><L><V><G><S><F><S><A><S><L><A><G><T><S><N><L><S><E><T><E><P><P><L><W><K><E><S><P><G><Q><L><S><D><Y><R><V><E><N><S><M><Y><I><I><N><P><W><V><Y><L><E><R><M><G><M><Y><K><I><I><L><N><Q><T><A><R><Y><F><A><K><F><A><P><D><N><E><Q><N><I><L><W><G><L><P><L><Q><Y><G><W><Q><Y><R><T><G><R><L><A><D><P><T><R><R><T><N><C><G><Y><E><S><G><D><H><M><C><I><S><V><D><S><W><W><A><D><L><N><Y><F><L><S><S><L><P><F><L><A><A><V><D><S><G><V><M><G><I><S><S><D><Q><V><R><L><L><P><P><P><K><N><E><R><K><F><C><Y><D><V><S><S><C><R><S><S><F><P><E><T><M><N><K><W><N><T><F><Y><Q><Y><L><Q><S><P><F><S><K><F><D><D><L><L><K><Y><L><W><A><A><H><T><S><T><L><A><D><N><I><K><S><F><E><D><R><Y><D><Y><Y><S><K><A><E><A><H><F><E><R><S><W><V><L><A><V><D><H><L><A><A><V><L><F><P><T><T><L><I><R><S><Y><K><F><Q><K><G><M><P><P><R><I><L><L><N><T><D><V><A><P><F><I><S><D><F><T><A><F><Q><N><V><V><L><V><L><L><N><M><L><D><N><V><D><K><S><I><G><Y><L><C><T><E><K><S><N><V><Y><R><D><H><S><E><S><S><S><R><S><Y><G><N><N><S> | May be involved in early liver development.<BOP> | Q6P5S2 |
O15204 | ADEC1_HUMAN | A disintegrin and metalloproteinase domain-like protein decysin-1 | Homo | <M><L><R><G><I><S><Q><L><P><A><V><A><T><M><S><W><V><L><L><P><V><L><W><L><I><V><Q><T><Q><A><I><A><I><K><Q><T><P><E><L><T><L><H><E><I><V><C><P><K><K><L><H><I><L><H><K><R><E><I><K><N><N><Q><T><E><K><H><G><K><E><E><R><Y><E><P><E><V><Q><Y><Q><M><I><L><N><G><E><E><I><I><L><S><L><Q><K><T><K><H><L><L><G><P><D><Y><T><E><T><L><Y><S><P><R><G><E><E><I><T><T><K><P><E><N><M><E><H><C><Y><Y><K><G><N><I><L><N><E><K><N><S><V><A><S><I><S><T><C><D><G><L><R><G><Y><F><T><H><H><H><Q><R><Y><Q><I><K><P><L><K><S><T><D><E><K><E><H><A><V><F><T><S><N><Q><E><E><Q><D><P><A><N><H><T><C><G><V><K><S><T><D><G><K><Q><G><P><I><R><I><S><R><S><L><K><S><P><E><K><E><D><F><L><R><A><Q><K><Y><I><D><L><Y><L><V><L><D><N><A><F><Y><K><N><Y><N><E><N><L><T><L><I><R><S><F><V><F><D><V><M><N><L><L><N><V><I><Y><N><T><I><D><V><Q><V><A><L><V><G><M><E><I><W><S><D><G><D><K><I><K><V><V><P><S><A><S><T><T><F><D><N><F><L><R><W><H><S><S><N><L><G><K><K><I><H><D><H><A><Q><L><L><S><G><I><S><F><N><N><R><R><V><G><L><A><A><S><N><S><L><C><S><P><S><S><V><A><V><I><E><A><K><K><K><N><N><V><A><L><V><G><V><M><S><H><E><L><G><H><V><L><G><M><P><D><V><P><F><N><T><K><C><P><S><G><S><C><V><M><N><Q><Y><L><S><S><K><F><P><K><D><F><S><T><S><C><R><A><H><F><E><R><Y><L><L><S><Q><K><P><K><C><L><L><Q><A><P><I><P><T><N><I><M><T><T><P><V><C><G><N><H><L><L><E><V><G><E><D><C><D><C><G><S><P><K><E><C><T><N><L><C><C><E><A><L><T><C><K><L><K><P><G><T><D><C><G><G><D><A><P><N><H><T><T><E> | May play an important role in the control of the immune response and during pregnancy.<BOP> | O15204 |
A0A0B4J2D9 | KVD13_HUMAN | Immunoglobulin kappa variable 1D-13 | Homo | <M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><P><G><A><R><C><A><I><Q><L><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><S><S><A><L><A><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><D><A><S><S><L><E><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><Q><Q><F><N><S><Y><P> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0B4J2D9 |
Q9H6Z4 | RANB3_HUMAN | Ran-binding protein 3 | Homo | <M><A><D><L><A><N><E><E><K><P><A><I><A><P><P><V><F><V><F><Q><K><D><K><G><Q><K><S><P><A><E><Q><K><N><L><S><D><S><G><E><E><P><R><G><E><A><E><A><P><H><H><G><T><G><H><P><E><S><A><G><E><H><A><L><E><P><P><A><P><A><G><A><S><A><S><T><P><P><P><P><A><P><E><A><Q><L><P><P><F><P><R><E><L><A><G><R><S><A><G><G><S><S><P><E><G><G><E><D><S><D><R><E><D><G><N><Y><C><P><P><V><K><R><E><R><T><S><S><L><T><Q><F><P><P><S><Q><S><E><E><R><S><S><G><F><R><L><K><P><P><T><L><I><H><G><Q><A><P><S><A><G><L><P><S><Q><K><P><K><E><Q><Q><R><S><V><L><R><P><A><V><L><Q><A><P><Q><P><K><A><L><S><Q><T><V><P><S><S><G><T><N><G><V><S><L><P><A><D><C><T><G><A><V><P><A><A><S><P><D><T><A><A><W><R><S><P><S><E><A><A><D><E><V><C><A><L><E><E><K><E><P><Q><K><N><E><S><S><N><A><S><E><E><E><A><C><E><K><K><D><P><A><T><Q><Q><A><F><V><F><G><Q><N><L><R><D><R><V><K><L><I><N><E><S><V><D><E><A><D><M><E><N><A><G><H><P><S><A><D><T><P><T><A><T><N><Y><F><L><Q><Y><I><S><S><S><L><E><N><S><T><N><S><A><D><A><S><S><N><K><F><V><F><G><Q><N><M><S><E><R><V><L><S><P><P><K><L><N><E><V><S><S><D><A><N><R><E><N><A><A><A><E><S><G><S><E><S><S><S><Q><E><A><T><P><E><K><E><S><L><A><E><S><A><A><A><Y><T><K><A><T><A><R><K><C><L><L><E><K><V><E><V><I><T><G><E><E><A><E><S><N><V><L><Q><M><Q><C><K><L><F><V><F><D><K><T><S><Q><S><W><V><E><R><G><R><G><L><L><R><L><N><D><M><A><S><T><D><D><G><T><L><Q><S><R><L><V><M><R><T><Q><G><S><L><R><L><I><L><N><T><K><L><W><A><Q><M><Q><I><D><K><A><S><E><K><S><I><R><I><T><A><M><D><T><E><D><Q><G><V><K><V><F><L><I><S><A><S><S><K><D><T><G><Q><L><Y><A><A><L><H><H><R><I><L><A><L><R><S><R><V><E><Q><E><Q><E><A><K><M><P><A><P><E><P><G><A><A><P><S><N><E><E><D><D><S><D><D><D><D><V><L><A><P><S><G><A><T><A><A><G><A><G><D><E><G><D><G><Q><T><T><G><S><T> | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<BOP> | Q9H6Z4 |
Q969R5 | LMBL2_HUMAN | Lethal(3)malignant brain tumor-like protein 2 | Homo | <M><E><K><P><R><S><I><E><E><T><P><S><S><E><P><M><E><E><E><E><D><D><D><L><E><L><F><G><G><Y><D><S><F><R><S><Y><N><S><S><V><G><S><E><S><S><S><Y><L><E><E><S><S><E><A><E><N><E><D><R><E><A><G><E><L><P><T><S><P><L><H><L><L><S><P><G><T><P><R><S><L><D><G><S><G><S><E><P><A><V><C><E><M><C><G><I><V><G><T><R><E><A><F><F><S><K><T><K><R><F><C><S><V><S><C><S><R><S><Y><S><S><N><S><K><K><A><S><I><L><A><R><L><Q><G><K><P><P><T><K><K><A><K><V><L><H><K><A><A><W><S><A><K><I><G><A><F><L><H><S><Q><G><T><G><Q><L><A><D><G><T><P><T><G><Q><D><A><L><V><L><G><F><D><W><G><K><F><L><K><D><H><S><Y><K><A><A><P><V><S><C><F><K><H><V><P><L><Y><D><Q><W><E><D><V><M><K><G><M><K><V><E><V><L><N><S><D><A><V><L><P><S><R><V><Y><W><I><A><S><V><I><Q><T><A><G><Y><R><V><L><L><R><Y><E><G><F><E><N><D><A><S><H><D><F><W><C><N><L><G><T><V><D><V><H><P><I><G><W><C><A><I><N><S><K><I><L><V><P><P><R><T><I><H><A><K><F><T><D><W><K><G><Y><L><M><K><R><L><V><G><S><R><T><L><P><V><D><F><H><I><K><M><V><E><S><M><K><Y><P><F><R><Q><G><M><R><L><E><V><V><D><K><S><Q><V><S><R><T><R><M><A><V><V><D><T><V><I><G><G><R><L><R><L><L><Y><E><D><G><D><S><D><D><D><F><W><C><H><M><W><S><P><L><I><H><P><V><G><W><S><R><R><V><G><H><G><I><K><M><S><E><R><R><S><D><M><A><H><H><P><T><F><R><K><I><Y><C><D><A><V><P><Y><L><F><K><K><V><R><A><V><Y><T><E><G><G><W><F><E><E><G><M><K><L><E><A><I><D><P><L><N><L><G><N><I><C><V><A><T><V><C><K><V><L><L><D><G><Y><L><M><I><C><V><D><G><G><P><S><T><D><G><L><D><W><F><C><Y><H><A><S><S><H><A><I><F><P><A><T><F><C><Q><K><N><D><I><E><L><T><P><P><K><G><Y><E><A><Q><T><F><N><W><E><N><Y><L><E><K><T><K><S><K><A><A><P><S><R><L><F><N><M><D><C><P><N><H><G><F><K><V><G><M><K><L><E><A><V><D><L><M><E><P><R><L><I><C><V><A><T><V><K><R><V><V><H><R><L><L><S><I><H><F><D><G><W><D><S><E><Y><D><Q><W><V><D><C><E><S><P><D><I><Y><P><V><G><W><C><E><L><T><G><Y><Q><L><Q><P><P><V><A><A><E><P><A><T><P><L><K><A><K><E><A><T><K><K><K><K><K><Q><F><G><K><K><R><K><R><I><P><P><T><K><T><R><P><L><R><Q><G><S><K><K><P><L><L><E><D><D><P><Q><G><A><R><K><I><S><S><E><P><V><P><G><E><I><I><A><V><R><V><K><E><E><H><L><D><V><A><S><P><D><K><A><S><S><P><E><L><P><V><S><V><E><N><I><K><Q><E><T><D><D> | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<BOP> | Q969R5 |
Q66K79 | CBPZ_HUMAN | Carboxypeptidase Z | Homo | <M><P><P><P><L><P><L><L><L><L><T><V><L><V><V><A><A><A><R><P><G><C><E><F><E><R><N><P><A><G><E><C><H><R><P><P><A><A><D><S><A><T><C><V><D><L><Q><L><R><T><C><S><D><A><A><Y><N><H><T><T><F><P><N><L><L><Q><H><R><S><W><E><V><V><E><A><S><S><E><Y><I><L><L><S><V><L><H><Q><L><L><E><G><Q><C><N><P><D><L><R><L><L><G><C><A><V><L><A><P><R><C><E><G><G><W><V><R><R><P><C><R><H><I><C><E><G><L><R><E><V><C><Q><P><A><F><D><A><I><D><M><A><W><P><Y><F><L><D><C><H><R><Y><F><T><R><E><D><E><G><C><Y><D><P><L><E><K><L><R><G><G><L><E><A><D><E><A><L><P><S><G><L><P><P><T><F><I><R><F><S><H><H><S><Y><A><Q><M><V><R><V><L><R><R><T><A><S><R><C><A><H><V><A><R><T><Y><S><I><G><R><S><F><D><G><R><E><L><L><V><I><E><F><S><S><R><P><G><Q><H><E><L><M><E><P><E><V><K><L><I><G><N><I><H><G><N><E><V><A><G><R><E><M><L><I><Y><L><A><Q><Y><L><C><S><E><Y><L><L><G><N><P><R><I><Q><R><L><L><N><T><T><R><I><H><L><L><P><S><M><N><P><D><G><Y><E><V><A><A><A><E><G><A><G><Y><N><G><W><T><S><G><R><Q><N><A><Q><N><L><D><L><N><R><N><F><P><D><L><T><S><E><Y><Y><R><L><A><E><T><R><G><A><R><S><D><H><I><P><I><P><Q><H><Y><W><W><G><K><V><A><P><E><T><K><A><I><M><K><W><M><Q><T><I><P><F><V><L><S><A><S><L><H><G><G><D><L><V><V><S><Y><P><F><D><F><S><K><H><P><Q><E><E><K><M><F><S><P><T><P><D><E><K><M><F><K><L><L><S><R><A><Y><A><D><V><H><P><M><M><M><D><R><S><E><N><R><C><G><G><N><F><L><K><R><G><S><I><I><N><G><A><D><W><Y><S><F><T><G><G><M><S><D><F><N><Y><L><H><T><N><C><F><E><I><T><V><E><L><G><C><V><K><F><P><P><E><E><A><L><Y><I><L><W><Q><H><N><K><E><S><L><L><N><F><V><E><T><V><H><R><G><I><K><G><V><V><T><D><K><F><G><K><P><V><K><N><A><R><I><S><V><K><G><I><R><H><D><I><T><T><A><P><D><G><D><Y><W><R><L><L><P><P><G><I><H><I><V><I><A><Q><A><P><G><Y><A><K><V><I><K><K><V><I><I><P><A><R><M><K><R><A><G><R><V><D><F><I><L><Q><P><L><G><M><G><P><K><N><F><I><H><G><L><R><R><T><G><P><H><D><P><L><G><G><A><S><S><L><G><E><A><T><E><P><D><P><L><R><A><R><R><Q><P><S><A><D><G><S><K><P><W><W><W><S><Y><F><T><S><L><S><T><H><R><P><R><W><L><L><K><Y> | Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.<BOP> | Q66K79 |
P06310 | KV230_HUMAN | Ig kappa chain V-II region RPMI 6410 | Homo | <M><R><L><P><A><Q><L><L><G><L><L><M><L><W><V><P><G><S><S><G><D><V><V><M><T><Q><S><P><L><S><L><P><V><T><L><G><Q><P><A><S><I><S><C><R><S><S><Q><S><L><V><Y><S><D><G><N><T><Y><L><N><W><F><Q><Q><R><P><G><Q><S><P><R><R><L><I><Y><K><V><S><N><R><D><S><G><V><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><K><I><S><R><V><E><A><E><D><V><G><V><Y><Y><C><M><Q><G><T><H><W><P> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P06310 |
Q8NFJ6 | PKR2_HUMAN | GPRg2 | Homo | <M><A><A><Q><N><G><N><T><S><F><T><P><N><F><N><P><P><Q><D><H><A><S><S><L><S><F><N><F><S><Y><G><D><Y><D><L><P><M><D><E><D><E><D><M><T><K><T><R><T><F><F><A><A><K><I><V><I><G><I><A><L><A><G><I><M><L><V><C><G><I><G><N><F><V><F><I><A><A><L><T><R><Y><K><K><L><R><N><L><T><N><L><L><I><A><N><L><A><I><S><D><F><L><V><A><I><I><C><C><P><F><E><M><D><Y><Y><V><V><R><Q><L><S><W><E><H><G><H><V><L><C><A><S><V><N><Y><L><R><T><V><S><L><Y><V><S><T><N><A><L><L><A><I><A><I><D><R><Y><L><A><I><V><H><P><L><K><P><R><M><N><Y><Q><T><A><S><F><L><I><A><L><V><W><M><V><S><I><L><I><A><I><P><S><A><Y><F><A><T><E><T><V><L><F><I><V><K><S><Q><E><K><I><F><C><G><Q><I><W><P><V><D><Q><Q><L><Y><Y><K><S><Y><F><L><F><I><F><G><V><E><F><V><G><P><V><V><T><M><T><L><C><Y><A><R><I><S><R><E><L><W><F><K><A><V><P><G><F><Q><T><E><Q><I><R><K><R><L><R><C><R><R><K><T><V><L><V><L><M><C><I><L><T><A><Y><V><L><C><W><A><P><F><Y><G><F><T><I><V><R><D><F><F><P><T><V><F><V><K><E><K><H><Y><L><T><A><F><Y><V><V><E><C><I><A><M><S><N><S><M><I><N><T><V><C><F><V><T><V><K><N><N><T><M><K><Y><F><K><K><M><M><L><L><H><W><R><P><S><Q><R><G><S><K><S><S><A><D><L><D><L><R><T><N><G><V><P><T><T><E><E><V><D><C><I><R><L><K> | Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.<BOP> | Q8NFJ6 |
Q8WUQ7 | CATIN_HUMAN | Renal carcinoma antigen NY-REN-24 | Homo | <M><G><R><D><T><R><S><R><S><R><S><A><G><R><R><G><R><R><R><Q><S><Q><S><G><S><R><S><R><S><R><S><H><G><R><R><N><R><R><R><R><E><D><E><G><R><R><R><R><R><R><R><S><R><E><R><R><S><D><S><E><E><E><R><W><Q><R><S><G><M><R><S><R><S><P><P><R><P><K><W><H><S><R><D><G><S><S><Q><S><D><S><G><E><E><Q><S><R><G><Q><W><A><R><R><R><R><R><A><R><S><W><S><P><S><S><S><A><S><S><S><A><S><P><G><R><S><Q><S><P><R><A><A><A><A><A><L><S><Q><Q><Q><S><L><Q><E><R><L><R><L><R><E><E><R><K><Q><Q><E><E><L><M><K><A><F><E><T><P><E><E><K><R><A><R><R><L><A><K><K><E><A><K><E><R><K><K><R><E><K><M><G><W><G><E><E><Y><M><G><Y><T><N><T><D><N><P><F><G><D><N><N><L><L><G><T><F><I><W><N><K><A><L><E><K><K><G><I><S><H><L><E><E><K><E><L><K><E><R><N><K><R><I><Q><E><D><N><R><L><E><L><Q><K><V><K><Q><L><R><L><E><R><E><R><E><K><A><M><R><E><Q><E><L><E><M><L><Q><R><E><K><E><A><E><H><F><K><T><W><E><E><Q><E><D><N><F><H><L><Q><Q><A><K><L><R><S><K><I><R><I><R><D><G><R><A><K><P><I><D><L><L><A><K><Y><I><S><A><E><D><D><D><L><A><V><E><M><H><E><P><Y><T><F><L><N><G><L><T><V><A><D><M><E><D><L><L><E><D><I><Q><V><Y><M><E><L><E><Q><G><K><N><A><D><F><W><R><D><M><T><T><I><T><E><D><E><I><S><K><L><R><K><L><E><A><S><G><K><G><P><G><E><R><R><E><G><V><N><A><S><V><S><S><D><V><Q><S><V><F><K><G><K><T><Y><N><Q><L><Q><V><I><F><Q><G><I><E><G><K><I><R><A><G><G><P><N><L><D><M><G><Y><W><E><S><L><L><Q><Q><L><R><A><H><M><A><R><A><R><L><R><E><R><H><Q><D><V><L><R><Q><K><L><Y><K><L><K><Q><E><Q><G><V><E><S><E><P><L><F><P><I><L><K><Q><E><P><Q><S><P><S><R><S><L><E><P><E><D><A><A><P><T><P><P><G><P><S><S><E><G><G><P><A><E><A><E><V><D><G><A><T><P><T><E><G><D><G><D><G><D><G><E><G><E><G><E><G><E><A><V><L><M><E><E><D><L><I><Q><Q><S><L><D><D><Y><D><A><G><R><Y><S><P><R><L><L><T><A><H><E><L><P><L><D><A><H><V><L><E><P><D><E><D><L><Q><R><L><Q><L><S><R><Q><Q><L><Q><V><T><G><D><A><S><E><S><A><E><D><I><F><F><R><R><A><K><E><G><M><G><Q><D><E><A><Q><F><S><V><E><M><P><L><T><G><K><A><Y><L><W><A><D><K><Y><R><P><R><K><P><R><F><F><N><R><V><H><T><G><F><E><W><N><K><Y><N><Q><T><H><Y><D><F><D><N><P><P><P><K><I><V><Q><G><Y><K><F><N><I><F><Y><P><D><L><I><D><K><R><S><T><P><E><Y><F><L><E><A><C><A><D><N><K><D><F><A><I><L><R><F><H><A><G><P><P><Y><E><D><I><A><F><K><I><V><N><R><E><W><E><Y><S><H><R><H><G><F><R><C><Q><F><A><N><G><I><F><Q><L><W><F><H><F><K><R><Y><R><Y><R><R> | Involved in the regulation of innate immune response . Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways . Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli .<BOP> | Q8WUQ7 |
O43653 | PSCA_HUMAN | Prostate stem cell antigen | Homo | <M><A><G><L><A><L><Q><P><G><T><A><L><L><C><Y><S><C><K><A><Q><V><S><N><E><D><C><L><Q><V><E><N><C><T><Q><L><G><E><Q><C><W><T><A><R><I><R><A><V><G><L><L><T><V><I><S><K><G><C><S><L><N><C><V><D><D><S><Q><D><Y><Y><V><G><K><K><N><I><T><C><C><D><T><D><L><C><N><A><S><G><A><H><A><L><Q><P><A><A><A><I><L><A><L><L><P><A><L><G><L><L><L><W><G><P><G><Q><L> | May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.<BOP> | O43653 |
Q5VIY5 | ZN468_HUMAN | Zinc finger protein 468 | Homo | <M><A><L><P><Q><G><L><L><T><F><R><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><D><I><S><S><K><C><M><L><K><T><L><S><S><T><G><Q><G><N><T><E><V><I><H><T><G><T><L><H><R><Q><A><S><H><H><I><G><E><F><C><F><H><E><I><E><K><D><I><H><G><F><E><F><Q><W><K><E><D><E><T><N><G><H><A><A><P><M><T><E><I><K><E><L><A><G><S><T><G><Q><H><D><Q><R><H><A><G><N><K><R><I><K><D><Q><L><G><S><S><F><H><L><H><L><P><E><P><H><I><F><Q><S><E><G><K><I><G><N><Q><V><E><K><S><I><N><N><A><S><S><V><S><T><S><Q><R><I><C><C><R><P><K><T><H><I><S><N><K><Y><G><N><N><S><L><H><S><S><L><L><T><Q><K><W><E><V><H><M><R><E><K><S><F><E><C><I><Q><S><F><K><S><F><N><C><S><S><L><L><K><K><H><Q><I><I><H><L><E><E><K><Q><C><K><C><D><V><C><G><K><V><F><N><Q><K><R><Y><L><A><C><H><R><R><C><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><G><H><N><S><S><L><F><I><H><K><A><L><H><T><G><E><K><P><Y><E><C><E><E><C><D><K><V><F><S><R><K><S><H><L><E><R><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><V><C><D><E><A><F><A><Y><N><S><Y><L><A><K><H><T><I><L><H><T><G><E><K><P><Y><T><C><N><E><C><G><K><V><F><N><R><L><S><T><L><A><R><H><H><R><L><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><V><F><S><R><K><S><H><L><E><R><H><R><R><I><H><S><G><E><K><P><Y><K><C><E><E><C><C><K><V><F><S><R><K><S><N><L><E><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><Q><R><D><S><H><L><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><G><Q><T><S><S><L><I><I><H><R><R><L><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><S><Q><M><S><S><L><V><Y><H><H><R><L><H><S><G><E><K><P> | May be involved in transcriptional regulation.<BOP> | Q5VIY5 |
Q6PIY7 | GLD2_HUMAN | Terminal uridylyltransferase 2 | Homo | <M><F><P><N><S><I><L><G><R><P><P><F><T><P><N><H><Q><Q><H><N><N><F><F><T><L><S><P><T><V><Y><S><H><Q><Q><L><I><D><A><Q><F><N><F><Q><N><A><D><L><S><R><A><V><S><L><Q><Q><L><T><Y><G><N><V><S><P><I><Q><T><S><A><S><P><L><F><R><G><R><K><R><L><S><D><E><K><N><L><P><L><D><G><K><R><Q><R><F><H><S><P><H><Q><E><P><T><V><V><N><Q><I><V><P><L><S><G><E><R><R><Y><S><M><P><P><L><F><H><T><H><Y><V><P><D><I><V><R><C><V><P><P><F><R><E><I><A><F><L><E><P><R><E><I><T><L><P><E><A><K><D><K><L><S><Q><Q><I><L><E><L><F><E><T><C><Q><Q><Q><I><S><D><L><K><K><K><E><L><C><R><T><Q><L><Q><R><E><I><Q><L><L><F><P><Q><S><R><L><F><L><V><G><S><S><L><N><G><F><G><T><R><S><S><D><G><D><L><C><L><V><V><K><E><E><P><C><F><F><Q><V><N><Q><K><T><E><A><R><H><I><L><T><L><V><H><K><H><F><C><T><R><L><S><G><Y><I><E><R><P><Q><L><I><R><A><K><V><P><I><V><K><F><R><D><K><V><S><C><V><E><F><D><L><N><V><N><N><I><V><G><I><R><N><T><F><L><L><R><T><Y><A><Y><L><E><N><R><V><R><P><L><V><L><V><I><K><K><W><A><S><H><H><Q><I><N><D><A><S><R><G><T><L><S><S><Y><S><L><V><L><M><V><L><H><Y><L><Q><T><L><P><E><P><I><L><P><S><L><Q><K><I><Y><P><E><S><F><S><P><A><I><Q><L><H><L><V><H><Q><A><P><C><N><V><P><P><Y><L><S><K><N><E><S><N><L><G><D><L><L><L><G><F><L><K><Y><Y><A><T><E><F><D><W><N><S><Q><M><I><S><V><R><E><A><K><A><I><P><R><P><D><G><I><E><W><R><N><K><Y><I><C><V><E><E><P><F><D><G><T><N><T><A><R><A><V><H><E><K><Q><K><F><D><M><I><K><D><Q><F><L><K><S><W><H><R><L><K><N><K><R><D><L><N><S><I><L><P><V><R><A><A><V><L><K><R> | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs . Does not play a role in replication-dependent histone mRNA degradation . Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs .<BOP> | Q6PIY7 |
Q9UBC7 | GALP_HUMAN | Galanin-like peptide | Homo | <M><A><P><P><S><V><P><L><V><L><L><L><V><L><L><L><S><L><A><E><T><P><A><S><A><P><A><H><R><G><R><G><G><W><T><L><N><S><A><G><Y><L><L><G><P><V><L><H><L><P><Q><M><G><D><Q><D><G><K><R><E><T><A><L><E><I><L><D><L><W><K><A><I><D><G><L><P><Y><S><H><P><P><Q><P><S><K><R><N><V><M><E><T><F><A><K><P><E><I><G><D><L><G><M><L><S><M><K><I><P><K><E><E><D><V><L><K><S> | Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing .<BOP> | Q9UBC7 |
Q9H0S4 | DDX47_HUMAN | DEAD box protein 47 | Homo | <M><A><A><P><E><E><H><D><S><P><T><E><A><S><Q><P><I><V><E><E><E><E><T><K><T><F><K><D><L><G><V><T><D><V><L><C><E><A><C><D><Q><L><G><W><T><K><P><T><K><I><Q><I><E><A><I><P><L><A><L><Q><G><R><D><I><I><G><L><A><E><T><G><S><G><K><T><G><A><F><A><L><P><I><L><N><A><L><L><E><T><P><Q><R><L><F><A><L><V><L><T><P><T><R><E><L><A><F><Q><I><S><E><Q><F><E><A><L><G><S><S><I><G><V><Q><S><A><V><I><V><G><G><I><D><S><M><S><Q><S><L><A><L><A><K><K><P><H><I><I><I><A><T><P><G><R><L><I><D><H><L><E><N><T><K><G><F><N><L><R><A><L><K><Y><L><V><M><D><E><A><D><R><I><L><N><M><D><F><E><T><E><V><D><K><I><L><K><V><I><P><R><D><R><K><T><F><L><F><S><A><T><M><T><K><K><V><Q><K><L><Q><R><A><A><L><K><N><P><V><K><C><A><V><S><S><K><Y><Q><T><V><E><K><L><Q><Q><Y><Y><I><F><I><P><S><K><F><K><D><T><Y><L><V><Y><I><L><N><E><L><A><G><N><S><F><M><I><F><C><S><T><C><N><N><T><Q><R><T><A><L><L><L><R><N><L><G><F><T><A><I><P><L><H><G><Q><M><S><Q><S><K><R><L><G><S><L><N><K><F><K><A><K><A><R><S><I><L><L><A><T><D><V><A><S><R><G><L><D><I><P><H><V><D><V><V><V><N><F><D><I><P><T><H><S><K><D><Y><I><H><R><V><G><R><T><A><R><A><G><R><S><G><K><A><I><T><F><V><T><Q><Y><D><V><E><L><F><Q><R><I><E><H><L><I><G><K><K><L><P><G><F><P><T><Q><D><D><E><V><M><M><L><T><E><R><V><A><E><A><Q><R><F><A><R><M><E><L><R><E><H><G><E><K><K><K><R><S><R><E><D><A><G><D><N><D><D><T><E><G><A><I><G><V><R><N><K><V><A><G><G><K><M><K><K><R><K><G><R> | Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.<BOP> | Q9H0S4 |
Q7Z7H3 | CATIP_HUMAN | Ciliogenesis-associated TTC17-interacting protein | Homo | <M><S><S><K><V><Y><S><T><G><S><R><A><K><D><H><Q><P><S><G><P><E><C><L><P><L><P><E><A><N><A><E><A><I><D><F><L><S><S><L><H><K><E><E><L><Q><M><L><F><F><S><E><T><L><A><M><V><S><D><T><G><E><P><Q><G><E><L><T><I><E><V><Q><R><G><K><Y><Q><E><K><L><G><M><L><T><Y><C><L><F><V><H><A><S><S><R><G><F><L><D><K><M><L><C><G><N><S><L><L><G><Y><L><S><E><K><L><E><L><M><E><Q><H><S><Q><D><F><I><K><F><L><I><L><P><M><E><R><K><M><S><L><L><K><Q><D><D><Q><L><A><V><T><R><S><I><K><E><G><E><E><V><K><T><G><V><T><S><F><P><W><S><S><I><K><G><F><I><S><E><A><A><N><L><V><L><L><R><V><M><A><W><R><R><M><V><P><S><N><A><R><F><L><T><L><D><T><E><G><K><L><C><Y><L><T><Y><Q><N><L><G><F><Q><T><I><Q><V><D><H><Q><Q><A><E><V><F><I><V><E><Q><T><V><H><A><E><E><G><I><P><M><S><C><Q><Y><Y><L><L><S><D><G><H><L><A><K><R><I><Q><V><G><S><P><G><C><C><I><I><T><K><M><P><I><L><R><E><E><D><E><I><E><P><R><P><V><F><E><K><K><P><L><V><W><E><E><D><M><E><L><Y><S><K><F><L><D><R><K><E><E><L><R><L><G><H><A><S><Y><L><R><Q><H><P><E><A><H><A><L><I><S><D><F><L><L><F><L><L><L><R><Q><P><E><D><V><V><T><F><A><A><E><F><F><G><P><F><D><P><W><R><P><S><S><P><A><L><G><S><S><H><R><P><N><P><F><R><S><L><E><P><E><G><D><A><R><S><G><A><A> | Plays a role in primary ciliogenesis by modulating actin polymerization.<BOP> | Q7Z7H3 |
A0A0B4J240 | TVA10_HUMAN | T cell receptor alpha variable 10 | Homo | <M><K><K><H><L><T><T><F><L><V><I><L><W><L><Y><F><Y><R><G><N><G><K><N><Q><V><E><Q><S><P><Q><S><L><I><I><L><E><G><K><N><C><T><L><Q><C><N><Y><T><V><S><P><F><S><N><L><R><W><Y><K><Q><D><T><G><R><G><P><V><S><L><T><I><M><T><F><S><E><N><T><K><S><N><G><R><Y><T><A><T><L><D><A><D><T><K><Q><S><S><L><H><I><T><A><S><Q><L><S><D><S><A><S><Y><I><C><V><V><S> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J240 |
Q16629 | SRSF7_HUMAN | Splicing factor, arginine/serine-rich 7 | Homo | <M><S><R><Y><G><R><Y><G><G><E><T><K><V><Y><V><G><N><L><G><T><G><A><G><K><G><E><L><E><R><A><F><S><Y><Y><G><P><L><R><T><V><W><I><A><R><N><P><P><G><F><A><F><V><E><F><E><D><P><R><D><A><E><D><A><V><R><G><L><D><G><K><V><I><C><G><S><R><V><R><V><E><L><S><T><G><M><P><R><R><S><R><F><D><R><P><P><A><R><R><P><F><D><P><N><D><R><C><Y><E><C><G><E><K><G><H><Y><A><Y><D><C><H><R><Y><S><R><R><R><R><S><R><S><R><S><R><S><H><S><R><S><R><G><R><R><Y><S><R><S><R><S><R><S><R><G><R><R><S><R><S><A><S><P><R><R><S><R><S><I><S><L><R><R><S><R><S><A><S><L><R><R><S><R><S><G><S><I><K><G><S><R><Y><F><Q><S><P><S><R><S><R><S><R><S><R><S><I><S><R><P><R><S><S><R><S><K><S><R><S><P><S><P><K><R><S><R><S><P><S><G><S><P><R><R><S><A><S><P><E><R><M><D> | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.<BOP> | Q16629 |
O14640 | DVL1_HUMAN | DSH homolog 1 | Homo | <M><A><E><T><K><I><I><Y><H><M><D><E><E><E><T><P><Y><L><V><K><L><P><V><A><P><E><R><V><T><L><A><D><F><K><N><V><L><S><N><R><P><V><H><A><Y><K><F><F><F><K><S><M><D><Q><D><F><G><V><V><K><E><E><I><F><D><D><N><A><K><L><P><C><F><N><G><R><V><V><S><W><L><V><L><A><E><G><A><H><S><D><A><G><S><Q><G><T><D><S><H><T><D><L><P><P><P><L><E><R><T><G><G><I><G><D><S><R><P><P><S><F><H><P><N><V><A><S><S><R><D><G><M><D><N><E><T><G><T><E><S><M><V><S><H><R><R><E><R><A><R><R><R><N><R><E><E><A><A><R><T><N><G><H><P><R><G><D><R><R><R><D><V><G><L><P><P><D><S><A><S><T><A><L><S><S><E><L><E><S><S><S><F><V><D><S><D><E><D><G><S><T><S><R><L><S><S><S><T><E><Q><S><T><S><S><R><L><I><R><K><H><K><R><R><R><R><K><Q><R><L><R><Q><A><D><R><A><S><S><F><S><S><I><T><D><S><T><M><S><L><N><I><V><T><V><T><L><N><M><E><R><H><H><F><L><G><I><S><I><V><G><Q><S><N><D><R><G><D><G><G><I><Y><I><G><S><I><M><K><G><G><A><V><A><A><D><G><R><I><E><P><G><D><M><L><L><Q><V><N><D><V><N><F><E><N><M><S><N><D><D><A><V><R><V><L><R><E><I><V><S><Q><T><G><P><I><S><L><T><V><A><K><C><W><D><P><T><P><R><S><Y><F><T><V><P><R><A><D><P><V><R><P><I><D><P><A><A><W><L><S><H><T><A><A><L><T><G><A><L><P><R><Y><G><T><S><P><C><S><S><A><V><T><R><T><S><S><S><S><L><T><S><S><V><P><G><A><P><Q><L><E><E><A><P><L><T><V><K><S><D><M><S><A><V><V><R><V><M><Q><L><P><D><S><G><L><E><I><R><D><R><M><W><L><K><I><T><I><A><N><A><V><I><G><A><D><V><V><D><W><L><Y><T><H><V><E><G><F><K><E><R><R><E><A><R><K><Y><A><S><S><L><L><K><H><G><F><L><R><H><T><V><N><K><I><T><F><S><E><Q><C><Y><Y><V><F><G><D><L><C><S><N><L><A><T><L><N><L><N><S><G><S><S><G><T><S><D><Q><D><T><L><A><P><L><P><H><P><A><A><P><W><P><L><G><Q><G><Y><P><Y><Q><Y><P><G><P><P><P><C><F><P><P><A><Y><Q><D><P><G><F><S><Y><G><S><G><S><T><G><S><Q><Q><S><E><G><S><K><S><S><G><S><T><R><S><S><R><R><A><P><G><R><E><K><E><R><R><A><A><G><A><G><G><S><G><S><E><S><D><H><T><A><P><S><G><V><G><S><S><W><R><E><R><P><A><G><Q><L><S><R><G><S><S><P><R><S><Q><A><S><A><T><A><P><G><L><P><P><P><H><P><T><T><K><A><Y><T><V><V><G><G><P><P><G><G><P><P><V><R><E><L><A><A><V><P><P><E><L><T><G><S><R><Q><S><F><Q><K><A><M><G><N><P><C><E><F><F><V><D><I><M> | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<BOP> | O14640 |
Q14296 | FASTK_HUMAN | Fas-activated serine/threonine kinase | Homo | <M><R><R><P><R><G><E><P><G><P><R><A><P><R><P><T><E><G><A><T><C><A><G><P><G><E><S><W><S><P><S><P><N><S><M><L><R><V><L><L><S><A><Q><T><S><P><A><R><L><S><G><L><L><L><I><P><P><V><Q><P><C><C><L><G><P><S><K><W><G><D><R><P><V><G><G><G><P><S><A><G><P><V><Q><G><L><Q><R><L><L><E><Q><A><K><S><P><G><E><L><L><R><W><L><G><Q><N><P><S><K><V><R><A><H><H><Y><S><V><A><L><R><R><L><G><Q><L><L><G><S><R><P><R><P><P><P><V><E><Q><V><T><L><Q><D><L><S><Q><L><I><I><R><N><C><P><S><F><D><I><H><T><I><H><V><C><L><H><L><A><V><L><L><G><F><P><S><D><G><P><L><V><C><A><L><E><Q><E><R><R><L><R><L><P><P><K><P><P><P><P><L><Q><P><L><L><R><G><G><Q><G><L><E><A><A><L><S><C><P><R><F><L><R><Y><P><R><Q><H><L><I><S><S><L><A><E><A><R><P><E><E><L><T><P><H><V><M><V><L><L><A><Q><H><L><A><R><H><R><L><R><E><P><Q><L><L><E><A><I><A><H><F><L><V><V><Q><E><T><Q><L><S><S><K><V><V><Q><K><L><V><L><P><F><G><R><L><N><Y><L><P><L><E><Q><Q><F><M><P><C><L><E><R><I><L><A><R><E><A><G><V><A><P><L><A><T><V><N><I><L><M><S><L><C><Q><L><R><C><L><P><F><R><A><L><H><F><V><F><S><P><G><F><I><N><Y><I><S><G><T><P><H><A><L><I><V><R><R><Y><L><S><L><L><D><T><A><V><E><L><E><L><P><G><Y><R><G><P><R><L><P><R><R><Q><Q><V><P><I><F><P><Q><P><L><I><T><D><R><A><R><C><K><Y><S><H><K><D><I><V><A><E><G><L><R><Q><L><L><G><E><E><K><Y><R><Q><D><L><T><V><P><P><G><Y><C><T><D><F><L><L><C><A><S><S><S><G><A><V><L><P><V><R><T><Q><D><P><F><L><P><Y><P><P><R><S><C><P><Q><G><Q><A><A><S><S><A><T><T><R><D><P><A><Q><R><V><V><L><V><L><R><E><R><W><H><F><C><R><D><G><R><V><L><L><G><S><R><A><L><R><E><R><H><L><G><L><M><G><Y><Q><L><L><P><L><P><F><E><E><L><E><S><Q><R><G><L><P><Q><L><K><S><Y><L><R><Q><K><L><Q><A><L><G><L><R><W><G><P><E><G><G> | Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.<BOP> | Q14296 |
P52803 | EFNA5_HUMAN | EPH-related receptor tyrosine kinase ligand 7 | Homo | <M><L><H><V><E><M><L><T><L><V><F><L><V><L><W><M><C><V><F><S><Q><D><P><G><S><K><A><V><A><D><R><Y><A><V><Y><W><N><S><S><N><P><R><F><Q><R><G><D><Y><H><I><D><V><C><I><N><D><Y><L><D><V><F><C><P><H><Y><E><D><S><V><P><E><D><K><T><E><R><Y><V><L><Y><M><V><N><F><D><G><Y><S><A><C><D><H><T><S><K><G><F><K><R><W><E><C><N><R><P><H><S><P><N><G><P><L><K><F><S><E><K><F><Q><L><F><T><P><F><S><L><G><F><E><F><R><P><G><R><E><Y><F><Y><I><S><S><A><I><P><D><N><G><R><R><S><C><L><K><L><K><V><F><V><R><P><T><N><S><C><M><K><T><I><G><V><H><D><R><V><F><D><V><N><D><K><V><E><N><S><L><E><P><A><D><D><T><V><H><E><S><A><E><P><S><R><G><E><N><A><A><Q><T><P><R><I><P><S><R><L><L><A><I><L><L><F><L><L><A><M><L><L><T><L> | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.<BOP> | P52803 |
P22612 | KAPCG_HUMAN | cAMP-dependent protein kinase catalytic subunit gamma | Homo | <M><G><N><A><P><A><K><K><D><T><E><Q><E><E><S><V><N><E><F><L><A><K><A><R><G><D><F><L><Y><R><W><G><N><P><A><Q><N><T><A><S><S><D><Q><F><E><R><L><R><T><L><G><M><G><S><F><G><R><V><M><L><V><R><H><Q><E><T><G><G><H><Y><A><M><K><I><L><N><K><Q><K><V><V><K><M><K><Q><V><E><H><I><L><N><E><K><R><I><L><Q><A><I><D><F><P><F><L><V><K><L><Q><F><S><F><K><D><N><S><Y><L><Y><L><V><M><E><Y><V><P><G><G><E><M><F><S><R><L><Q><R><V><G><R><F><S><E><P><H><A><C><F><Y><A><A><Q><V><V><L><A><V><Q><Y><L><H><S><L><D><L><I><H><R><D><L><K><P><E><N><L><L><I><D><Q><Q><G><Y><L><Q><V><T><D><F><G><F><A><K><R><V><K><G><R><T><W><T><L><C><G><T><P><E><Y><L><A><P><E><I><I><L><S><K><G><Y><N><K><A><V><D><W><W><A><L><G><V><L><I><Y><E><M><A><V><G><F><P><P><F><Y><A><D><Q><P><I><Q><I><Y><E><K><I><V><S><G><R><V><R><F><P><S><K><L><S><S><D><L><K><H><L><L><R><S><L><L><Q><V><D><L><T><K><R><F><G><N><L><R><N><G><V><G><D><I><K><N><H><K><W><F><A><T><T><S><W><I><A><I><Y><E><K><K><V><E><A><P><F><I><P><K><Y><T><G><P><G><D><A><S><N><F><D><D><Y><E><E><E><E><L><R><I><S><I><N><E><K><C><A><K><E><F><S><E><F> | Phosphorylates a large number of substrates in the cytoplasm and the nucleus.<BOP> | P22612 |
P31273 | HXC8_HUMAN | Homeobox protein Hox-3A | Homo | <M><S><S><Y><F><V><N><P><L><F><S><K><Y><K><A><G><E><S><L><E><P><A><Y><Y><D><C><R><F><P><Q><S><V><G><R><S><H><A><L><V><Y><G><P><G><G><S><A><P><G><F><Q><H><A><S><H><H><V><Q><D><F><F><H><H><G><T><S><G><I><S><N><S><G><Y><Q><Q><N><P><C><S><L><S><C><H><G><D><A><S><K><F><Y><G><Y><E><A><L><P><R><Q><S><L><Y><G><A><Q><Q><E><A><S><V><V><Q><Y><P><D><C><K><S><S><A><N><T><N><S><S><E><G><Q><G><H><L><N><Q><N><S><S><P><S><L><M><F><P><W><M><R><P><H><A><P><G><R><R><S><G><R><Q><T><Y><S><R><Y><Q><T><L><E><L><E><K><E><F><L><F><N><P><Y><L><T><R><K><R><R><I><E><V><S><H><A><L><G><L><T><E><R><Q><V><K><I><W><F><Q><N><R><R><M><K><W><K><K><E><N><N><K><D><K><L><P><G><A><R><D><E><E><K><V><E><E><E><G><N><E><E><E><E><K><E><E><E><E><K><E><E><N><K><D> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P31273 |
Q6MZT1 | R7BP_HUMAN | R7 family-binding protein | Homo | <M><S><S><A><P><N><G><R><K><K><R><P><S><R><S><T><R><S><S><I><F><Q><I><S><K><P><P><L><Q><S><G><D><W><E><R><R><G><S><G><S><E><S><A><H><K><T><Q><R><A><L><D><D><C><K><M><L><V><Q><E><F><N><T><Q><V><A><L><Y><R><E><L><V><I><S><I><G><D><V><S><V><S><C><P><S><L><R><A><E><M><H><K><T><R><T><K><G><C><E><M><A><R><Q><A><H><Q><K><L><A><A><I><S><G><P><E><D><G><E><I><H><P><E><I><C><R><L><Y><I><Q><L><Q><C><C><L><E><M><Y><T><T><E><M><L><K><S><I><C><L><L><G><S><L><Q><F><H><R><K><G><K><E><P><G><G><G><T><K><S><L><D><C><K><I><E><E><S><A><E><T><P><A><L><E><D><S><S><S><S><P><V><D><S><Q><Q><H><S><W><Q><V><S><T><D><I><E><N><T><E><R><D><M><R><E><M><K><N><L><L><S><K><L><R><E><T><M><P><L><P><L><K><N><Q><D><D><S><S><L><L><N><L><T><P><Y><P><L><V><R><R><R><K><R><R><F><F><G><L><C><C><L><I><S><S> | Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.<BOP> | Q6MZT1 |
Q3MIV0 | KR221_HUMAN | Keratin-associated protein 22-1 | Homo | <M><S><F><D><N><N><Y><H><G><G><Q><G><Y><A><K><G><G><L><G><C><S><Y><G><C><G><L><S><G><Y><G><Y><A><C><Y><C><P><W><C><Y><E><R><S><W><F><S><G><C><F> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q3MIV0 |
Q8WW12 | PCNP_HUMAN | PEST proteolytic signal-containing nuclear protein | Homo | <M><A><D><G><K><A><G><D><E><K><P><E><K><S><Q><R><A><G><A><A><G><G><P><E><E><E><A><E><K><P><V><K><T><K><T><V><S><S><S><N><G><G><E><S><S><S><R><S><A><E><K><R><S><A><E><E><E><A><A><D><L><P><T><K><P><T><K><I><S><K><F><G><F><A><I><G><S><Q><T><T><K><K><A><S><A><I><S><I><K><L><G><S><S><K><P><K><E><T><V><P><T><L><A><P><K><T><L><S><V><A><A><A><F><N><E><D><E><D><S><E><P><E><E><M><P><P><E><A><K><M><R><M><K><N><I><G><R><D><T><P><T><S><A><G><P><N><S><F><N><K><G><K><H><G><F><S><D><N><Q><K><L><W><E><R><N><I><K><S><H><L><G><N><V><H><D><Q><D><N> | May be involved in cell cycle regulation.<BOP> | Q8WW12 |
A0A075B6J6 | LV322_HUMAN | Immunoglobulin lambda variable 3-22 | Homo | <M><A><W><A><T><L><L><L><P><L><L><N><L><Y><T><G><S><V><A><S><Y><E><L><T><Q><L><P><S><V><S><V><S><P><G><Q><T><A><R><I><T><C><S><G><D><V><L><G><E><N><Y><A><D><W><Y><Q><Q><K><P><G><Q><A><P><E><L><V><I><Y><E><D><S><E><R><Y><P><G><I><P><E><R><F><S><G><S><T><S><G><N><T><T><T><L><T><I><S><R><V><L><T><E><D><E><A><D><Y><Y><C><L><S><G><D><E><D><N><P><S> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6J6 |
Q8NGA0 | OR7G1_HUMAN | Olfactory receptor OR19-8 | Homo | <M><G><P><R><N><Q><T><A><V><S><E><F><L><L><M><K><V><T><E><D><P><E><L><K><L><I><P><F><S><L><F><L><S><M><Y><L><V><T><I><L><G><N><L><L><I><L><L><A><V><I><S><D><S><H><L><H><T><P><M><Y><F><L><L><F><N><L><S><F><T><D><I><C><L><T><T><T><T><V><P><K><I><L><V><N><I><Q><A><Q><N><Q><S><I><T><Y><T><G><C><L><T><Q><I><C><L><V><L><V><F><A><G><L><E><S><C><F><L><A><V><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><T><V><L><M><N><V><H><F><W><G><L><L><I><L><L><S><M><F><M><S><T><M><D><A><L><V><Q><S><L><M><V><L><Q><L><S><F><C><K><N><V><E><I><P><L><F><F><C><E><V><V><Q><V><I><K><L><A><C><S><D><T><L><I><N><N><I><L><I><Y><F><A><S><S><V><F><G><A><I><P><L><S><G><I><I><F><S><Y><S><Q><I><V><T><S><V><L><R><M><P><S><A><R><G><K><Y><K><A><F><S><T><C><G><C><H><L><S><V><F><S><L><F><Y><G><T><A><F><G><V><Y><I><S><S><A><V><A><E><S><S><R><I><T><A><V><A><S><V><M><Y><T><V><V><P><Q><M><M><N><P><F><I><Y><S><L><R><N><K><E><M><K><K><A><L><R><K><L><I><G><R><L><F><P><F> | Odorant receptor.<BOP> | Q8NGA0 |
Q9C0K3 | ARP3C_HUMAN | Actin-related protein 11 | Homo | <M><F><E><S><F><N><V><P><G><L><Y><I><A><V><Q><A><V><L><A><L><A><A><S><W><T><S><R><Q><V><G><E><R><T><L><T><G><I><V><I><D><S><G><D><G><V><T><H><V><I><P><V><A><E><G><Y><V><I><G><S><C><I><K><H><I><P><I><A><G><R><D><I><T><Y><F><I><Q><Q><L><L><R><E><R><E><V><G><I><P><P><E><Q><S><L><E><T><A><K><A><I><K><E><K><Y><C><Y><I><C><P><D><I><V><K><E><F><A><K><Y><D><V><D><P><Q><K><W><I><K><Q><Y><T><G><I><N><A><I><N><Q><K><K><F><V><I><D><V><G><Y><E><R><F><L><G><P><E><I><F><F><H><P><E><F><A><N><P><D><S><M><E><S><I><S><D><V><V><D><E><V><I><Q><N><C><P><I><D><V><R><R><P><L><Y><K><M><E><Q><I><P><L><S><Y><P><Q><G><H><G><F><H><P><L><S><P><P><F><H> | May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.<BOP> | Q9C0K3 |
Q99811 | PRRX2_HUMAN | Paired-related homeobox protein 2 | Homo | <M><D><S><A><A><A><A><F><A><L><D><K><P><A><L><G><P><G><P><P><P><P><P><P><A><L><G><P><G><D><C><A><Q><A><R><K><N><F><S><V><S><H><L><L><D><L><E><E><V><A><A><A><G><R><L><A><A><R><P><G><A><R><A><E><A><R><E><G><A><A><R><E><P><S><G><G><S><S><G><S><E><A><A><P><Q><D><G><E><C><P><S><P><G><R><G><S><A><A><K><R><K><K><K><Q><R><R><N><R><T><T><F><N><S><S><Q><L><Q><A><L><E><R><V><F><E><R><T><H><Y><P><D><A><F><V><R><E><E><L><A><R><R><V><N><L><S><E><A><R><V><Q><V><W><F><Q><N><R><R><A><K><F><R><R><N><E><R><A><M><L><A><S><R><S><A><S><L><L><K><S><Y><S><Q><E><A><A><I><E><Q><P><V><A><P><R><P><T><A><L><S><P><D><Y><L><S><W><T><A><S><S><P><Y><S><T><V><P><P><Y><S><P><G><S><S><G><P><A><T><P><G><V><N><M><A><N><S><I><A><S><L><R><L><K><A><K><E><F><S><L><H><H><S><Q><V><P><T><V><N> | May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.<BOP> | Q99811 |
Q8N8Y5 | ZFP41_HUMAN | Zinc finger protein 41 homolog | Homo | <M><E><K><P><A><G><R><K><K><K><T><P><T><P><R><E><E><A><D><V><Q><K><S><A><L><R><E><E><K><V><S><G><D><R><K><P><P><E><R><P><T><V><P><R><K><P><R><T><E><P><C><L><S><P><E><D><E><E><H><V><F><D><A><F><D><A><S><F><K><D><D><F><E><G><V><P><V><F><I><P><F><Q><R><K><K><P><Y><E><C><S><E><C><G><R><I><F><K><H><K><T><D><H><I><R><H><Q><R><V><H><T><G><E><K><P><F><K><C><A><Q><C><G><K><A><F><R><H><S><S><D><V><T><K><H><Q><R><T><H><T><G><E><K><P><F><K><C><G><E><C><G><K><A><F><N><C><G><S><N><L><L><K><H><Q><K><T><H><T><G><E><K><P><Y><E><C><T><H><C><G><K><A><F><A><Y><S><S><C><L><I><R><H><Q><K><R><H><P><R><K><K><P> | A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.<BOP> | Q8N8Y5 |
P17752 | TPH1_HUMAN | Tryptophan 5-monooxygenase 1 | Homo | <M><I><E><D><N><K><E><N><K><D><H><S><L><E><R><G><R><A><S><L><I><F><S><L><K><N><E><V><G><G><L><I><K><A><L><K><I><F><Q><E><K><H><V><N><L><L><H><I><E><S><R><K><S><K><R><R><N><S><E><F><E><I><F><V><D><C><D><I><N><R><E><Q><L><N><D><I><F><H><L><L><K><S><H><T><N><V><L><S><V><N><L><P><D><N><F><T><L><K><E><D><G><M><E><T><V><P><W><F><P><K><K><I><S><D><L><D><H><C><A><N><R><V><L><M><Y><G><S><E><L><D><A><D><H><P><G><F><K><D><N><V><Y><R><K><R><R><K><Y><F><A><D><L><A><M><N><Y><K><H><G><D><P><I><P><K><V><E><F><T><E><E><E><I><K><T><W><G><T><V><F><Q><E><L><N><K><L><Y><P><T><H><A><C><R><E><Y><L><K><N><L><P><L><L><S><K><Y><C><G><Y><R><E><D><N><I><P><Q><L><E><D><V><S><N><F><L><K><E><R><T><G><F><S><I><R><P><V><A><G><Y><L><S><P><R><D><F><L><S><G><L><A><F><R><V><F><H><C><T><Q><Y><V><R><H><S><S><D><P><F><Y><T><P><E><P><D><T><C><H><E><L><L><G><H><V><P><L><L><A><E><P><S><F><A><Q><F><S><Q><E><I><G><L><A><S><L><G><A><S><E><E><A><V><Q><K><L><A><T><C><Y><F><F><T><V><E><F><G><L><C><K><Q><D><G><Q><L><R><V><F><G><A><G><L><L><S><S><I><S><E><L><K><H><A><L><S><G><H><A><K><V><K><P><F><D><P><K><I><T><C><K><Q><E><C><L><I><T><T><F><Q><D><V><Y><F><V><S><E><S><F><E><D><A><K><E><K><M><R><E><F><T><K><T><I><K><R><P><F><G><V><K><Y><N><P><Y><T><R><S><I><Q><I><L><K><D><T><K><S><I><T><S><A><M><N><E><L><Q><H><D><L><D><V><V><S><D><A><L><A><K><V><S><R><K><P><S><I> | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.<BOP> | P17752 |
Q9NUE0 | ZDH18_HUMAN | Zinc finger DHHC domain-containing protein 18 | Homo | <M><K><D><C><E><Y><Q><Q><I><S><P><G><A><A><P><L><P><A><S><P><G><A><R><R><P><G><P><A><A><S><P><T><P><G><P><G><P><A><P><P><A><A><P><A><P><P><R><W><S><S><S><G><S><G><S><G><S><G><S><G><S><L><G><R><R><P><R><R><K><W><E><V><F><P><G><R><N><R><F><Y><C><G><G><R><L><M><L><A><G><H><G><G><V><F><A><L><T><L><L><L><I><L><T><T><T><G><L><F><F><V><F><D><C><P><Y><L><A><R><K><L><T><L><A><I><P><I><I><A><A><I><L><F><F><F><V><M><S><C><L><L><Q><T><S><F><T><D><P><G><I><L><P><R><A><T><V><C><E><A><A><A><L><E><K><Q><I><D><N><T><G><S><S><T><Y><R><P><P><P><R><T><R><E><V><L><I><N><G><Q><M><V><K><L><K><Y><C><F><T><C><K><M><F><R><P><P><R><T><S><H><C><S><V><C><D><N><C><V><E><R><F><D><H><H><C><P><W><V><G><N><C><V><G><R><R><N><Y><R><F><F><Y><A><F><I><L><S><L><S><F><L><T><A><F><I><F><A><C><V><V><T><H><L><T><L><R><A><Q><G><S><N><F><L><S><T><L><K><E><T><P><A><S><V><L><E><L><V><I><C><F><F><S><I><W><S><I><L><G><L><S><G><F><H><T><Y><L><V><A><S><N><L><T><T><N><E><D><I><K><G><S><W><S><S><K><R><G><G><E><A><S><V><N><P><Y><S><H><K><S><I><I><T><N><C><C><A><V><L><C><G><P><L><P><P><S><L><I><D><R><R><G><F><V><Q><S><D><T><V><L><P><S><P><I><R><S><D><E><P><A><C><R><A><K><P><D><A><S><M><V><G><G><H><P> | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK . Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS . May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling .<BOP> | Q9NUE0 |
Q10588 | BST1_HUMAN | Cyclic ADP-ribose hydrolase 2 | Homo | <M><A><A><Q><G><C><A><A><S><R><L><L><Q><L><L><L><Q><L><L><L><L><L><L><L><L><A><A><G><G><A><R><A><R><W><R><G><E><G><T><S><A><H><L><R><D><I><F><L><G><R><C><A><E><Y><R><A><L><L><S><P><E><Q><R><N><K><N><C><T><A><I><W><E><A><F><K><V><A><L><D><K><D><P><C><S><V><L><P><S><D><Y><D><L><F><I><N><L><S><R><H><S><I><P><R><D><K><S><L><F><W><E><N><S><H><L><L><V><N><S><F><A><D><N><T><R><R><F><M><P><L><S><D><V><L><Y><G><R><V><A><D><F><L><S><W><C><R><Q><K><N><D><S><G><L><D><Y><Q><S><C><P><T><S><E><D><C><E><N><N><P><V><D><S><F><W><K><R><A><S><I><Q><Y><S><K><D><S><S><G><V><I><H><V><M><L><N><G><S><E><P><T><G><A><Y><P><I><K><G><F><F><A><D><Y><E><I><P><N><L><Q><K><E><K><I><T><R><I><E><I><W><V><M><H><E><I><G><G><P><N><V><E><S><C><G><E><G><S><M><K><V><L><E><K><R><L><K><D><M><G><F><Q><Y><S><C><I><N><D><Y><R><P><V><K><L><L><Q><C><V><D><H><S><T><H><P><D><C><A><L><K><S><A><A><A><A><T><Q><R><K><A><P><S><L><Y><T><E><Q><R><A><G><L><I><I><P><L><F><L><V><L><A><S><R><T><Q><L> | Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) . Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).<BOP> | Q10588 |
P17025 | ZN182_HUMAN | Zinc finger protein KOX14 | Homo | <M><T><P><A><S><A><S><G><E><D><S><G><S><F><Y><S><W><Q><K><A><K><R><E><Q><G><L><V><T><F><E><D><V><A><V><D><F><T><Q><E><E><W><Q><Y><L><N><P><P><Q><R><T><L><Y><R><D><V><M><L><E><T><Y><S><N><L><V><F><V><G><Q><Q><V><T><K><P><N><L><I><L><K><L><E><V><E><E><C><P><A><E><G><K><I><P><F><W><N><F><P><E><V><C><Q><V><D><E><Q><I><E><R><Q><H><Q><D><D><Q><D><K><C><L><L><M><Q><V><G><F><S><D><K><K><T><I><I><T><K><S><A><R><D><C><H><E><F><G><N><I><L><H><L><S><T><N><L><V><A><S><I><Q><R><P><D><K><H><E><S><F><G><N><N><M><V><D><N><L><D><L><F><S><R><S><S><A><E><N><K><Y><D><N><G><C><A><K><L><F><F><H><T><E><Y><E><K><T><N><P><G><M><K><P><Y><G><Y><K><E><C><G><K><G><L><R><R><K><K><G><L><S><L><H><Q><R><I><K><N><G><E><K><P><F><E><C><T><A><C><R><K><T><F><S><K><K><S><H><L><I><V><H><W><R><T><H><T><G><E><K><P><F><G><C><T><E><C><G><K><A><F><S><Q><K><S><Q><L><I><I><H><L><R><T><H><T><G><E><R><P><F><E><C><P><E><C><G><K><A><F><R><E><K><S><T><V><I><I><H><Y><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><T><Q><K><S><N><L><I><V><H><Q><K><T><H><T><G><E><K><T><Y><E><C><T><K><C><G><E><S><F><I><Q><K><L><D><L><I><I><H><H><S><T><H><T><G><K><K><P><H><E><C><N><E><C><K><K><T><F><S><D><K><S><T><L><I><I><H><Q><R><T><H><T><G><E><K><P><H><K><C><T><E><C><G><K><S><F><N><E><K><S><T><L><I><V><H><Q><R><T><H><T><G><E><K><P><Y><E><C><D><V><C><G><K><T><F><T><Q><K><S><N><L><G><V><H><Q><R><T><H><S><G><E><K><P><F><E><C><N><E><C><E><K><A><F><S><Q><K><S><Y><L><M><L><H><Q><R><G><H><T><G><E><K><P><Y><E><C><N><E><C><E><K><A><F><S><Q><K><S><Y><L><I><I><H><Q><R><T><H><T><E><E><K><P><Y><K><C><N><E><C><G><K><A><F><R><E><K><S><K><L><I><I><H><Q><R><I><H><T><G><E><K><P><Y><E><C><P><V><C><W><K><A><F><S><Q><K><S><Q><L><I><I><H><Q><R><T><H><T><G><E><K><P><Y><A><C><T><E><C><G><K><A><F><R><E><K><S><T><F><T><V><H><Q><R><T><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><T><Q><K><S><N><L><I><V><H><Q><R><T><H><A><G><K><K><A><H><G><R><G><H><T><R><K><S><K><F><M><A><H> | May be involved in transcriptional regulation.<BOP> | P17025 |
Q9NR56 | MBNL1_HUMAN | Triplet-expansion RNA-binding protein | Homo | <M><A><V><S><V><T><P><I><R><D><T><K><W><L><T><L><E><V><C><R><E><F><Q><R><G><T><C><S><R><P><D><T><E><C><K><F><A><H><P><S><K><S><C><Q><V><E><N><G><R><V><I><A><C><F><D><S><L><K><G><R><C><S><R><E><N><C><K><Y><L><H><P><P><P><H><L><K><T><Q><L><E><I><N><G><R><N><N><L><I><Q><Q><K><N><M><A><M><L><A><Q><Q><M><Q><L><A><N><A><M><M><P><G><A><P><L><Q><P><V><P><M><F><S><V><A><P><S><L><A><T><N><A><S><A><A><A><F><N><P><Y><L><G><P><V><S><P><S><L><V><P><A><E><I><L><P><T><A><P><M><L><V><T><G><N><P><G><V><P><V><P><A><A><A><A><A><A><A><Q><K><L><M><R><T><D><R><L><E><V><C><R><E><Y><Q><R><G><N><C><N><R><G><E><N><D><C><R><F><A><H><P><A><D><S><T><M><I><D><T><N><D><N><T><V><T><V><C><M><D><Y><I><K><G><R><C><S><R><E><K><C><K><Y><F><H><P><P><A><H><L><Q><A><K><I><K><A><A><Q><Y><Q><V><N><Q><A><A><A><A><Q><A><A><A><T><A><A><A><M><T><Q><S><A><V><K><S><L><K><R><P><L><E><A><T><F><D><L><G><I><P><Q><A><V><L><P><P><L><P><K><R><P><A><L><E><K><T><N><G><A><T><A><V><F><N><T><G><I><F><Q><Y><Q><Q><A><L><A><N><M><Q><L><Q><Q><H><T><A><F><L><P><P><V><P><M><V><H><G><A><T><P><A><T><V><S><A><A><T><T><S><A><T><S><V><P><F><A><A><T><A><T><A><N><Q><I><P><I><I><S><A><E><H><L><T><S><H><K><Y><V><T><Q><M> | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.<BOP> | Q9NR56 |
Q9BQI0 | AIF1L_HUMAN | Ionized calcium-binding adapter molecule 2 | Homo | <M><S><G><E><L><S><N><R><F><Q><G><G><K><A><F><G><L><L><K><A><R><Q><E><R><R><L><A><E><I><N><R><E><F><L><C><D><Q><K><Y><S><D><E><E><N><L><P><E><K><L><T><A><F><K><E><K><Y><M><E><F><D><L><N><N><E><G><E><I><D><L><M><S><L><K><R><M><M><E><K><L><G><V><P><K><T><H><L><E><M><K><K><M><I><S><E><V><T><G><G><V><S><D><T><I><S><Y><R><D><F><V><N><M><M><L><G><K><R><S><A><V><L><K><L><V><M><M><F><E><G><K><A><N><E><S><S><P><K><P><V><G><P><P><P><E><R><D><I><A><S><L><P> | Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.<BOP> | Q9BQI0 |
Q96SZ5 | AEDO_HUMAN | Cysteamine dioxygenase | Homo | <M><P><R><D><N><M><A><S><L><I><Q><R><I><A><R><Q><A><C><L><T><F><R><G><S><G><G><G><R><G><A><S><D><R><D><A><A><S><G><P><E><A><P><M><Q><P><G><F><P><E><N><L><S><K><L><K><S><L><L><T><Q><L><R><A><E><D><L><N><I><A><P><R><K><A><T><L><Q><P><L><P><P><N><L><P><P><V><T><Y><M><H><I><Y><E><T><D><G><F><S><L><G><V><F><L><L><K><S><G><T><S><I><P><L><H><D><H><P><G><M><H><G><M><L><K><V><L><Y><G><T><V><R><I><S><C><M><D><K><L><D><A><G><G><G><Q><R><P><R><A><L><P><P><E><Q><Q><F><E><P><P><L><Q><P><R><E><R><E><A><V><R><P><G><V><L><R><S><R><A><E><Y><T><E><A><S><G><P><C><I><L><T><P><H><R><D><N><L><H><Q><I><D><A><V><E><G><P><A><A><F><L><D><I><L><A><P><P><Y><D><P><D><D><G><R><D><C><H><Y><Y><R><V><L><E><P><V><R><P><K><E><A><S><S><S><A><C><D><L><P><R><E><V><W><L><L><E><T><P><Q><A><D><D><F><W><C><E><G><E><P><Y><P><G><P><K><V><F><P> | Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate . Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine . Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) .<BOP> | Q96SZ5 |
Q7Z614 | SNX20_HUMAN | Selectin ligand-interactor cytoplasmic 1 | Homo | <M><A><S><P><E><H><P><G><S><P><G><C><M><G><P><I><T><Q><C><T><A><R><T><Q><Q><E><A><P><A><T><G><P><D><L><P><H><P><G><P><D><G><H><L><D><T><H><S><G><L><S><S><N><S><S><M><T><T><R><E><L><Q><Q><Y><W><Q><N><Q><K><C><R><W><K><H><V><K><L><L><F><E><I><A><S><A><R><I><E><E><R><K><V><S><K><F><V><V><Y><Q><I><I><V><I><Q><T><G><S><F><D><N><N><K><A><V><L><E><R><R><Y><S><D><F><A><K><L><Q><K><A><L><L><K><T><F><R><E><E><I><E><D><V><E><F><P><R><K><H><L><T><G><N><F><A><E><E><M><I><C><E><R><R><R><A><L><Q><E><Y><L><G><L><L><Y><A><I><R><C><V><R><R><S><R><E><F><L><D><F><L><T><R><P><E><L><R><E><A><F><G><C><L><R><A><G><Q><Y><P><R><A><L><E><L><L><L><R><V><L><P><L><Q><E><K><L><T><A><H><C><P><A><A><A><V><P><A><L><C><A><V><L><L><C><H><R><D><L><D><R><P><A><E><A><F><A><A><G><E><R><A><L><Q><R><L><Q><A><R><E><G><H><R><Y><Y><A><P><L><L><D><A><M><V><R><L><A><Y><A><L><G><K><D><F><V><T><L><Q><E><R><L><E><E><S><Q><L><R><R><P><T><P><R><G><I><T><L><K><E><L><T><V><R><E><Y><L><H> | May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.<BOP> | Q7Z614 |
O75635 | SPB7_HUMAN | TP55 | Homo | <M><A><S><L><A><A><A><N><A><E><F><C><F><N><L><F><R><E><M><D><D><N><Q><G><N><G><N><V><F><F><S><S><L><S><L><F><A><A><L><A><L><V><R><L><G><A><Q><D><D><S><L><S><Q><I><D><K><L><L><H><V><N><T><A><S><G><Y><G><N><S><S><N><S><Q><S><G><L><Q><S><Q><L><K><R><V><F><S><D><I><N><A><S><H><K><D><Y><D><L><S><I><V><N><G><L><F><A><E><K><V><Y><G><F><H><K><D><Y><I><E><C><A><E><K><L><Y><D><A><K><V><E><R><V><D><F><T><N><H><L><E><D><T><R><R><N><I><N><K><W><V><E><N><E><T><H><G><K><I><K><N><V><I><G><E><G><G><I><S><S><S><A><V><M><V><L><V><N><A><V><Y><F><K><G><K><W><Q><S><A><F><T><K><S><E><T><I><N><C><H><F><K><S><P><K><C><S><G><K><A><V><A><M><M><H><Q><E><R><K><F><N><L><S><V><I><E><D><P><S><M><K><I><L><E><L><R><Y><N><G><G><I><N><M><Y><V><L><L><P><E><N><D><L><S><E><I><E><N><K><L><T><F><Q><N><L><M><E><W><T><N><P><R><R><M><T><S><K><Y><V><E><V><F><F><P><Q><F><K><I><E><K><N><Y><E><M><K><Q><Y><L><R><A><L><G><L><K><D><I><F><D><E><S><K><A><D><L><S><G><I><A><S><G><G><R><L><Y><I><S><R><M><M><H><K><S><Y><I><E><V><T><E><E><G><T><E><A><T><A><A><T><G><S><N><I><V><E><K><Q><L><P><Q><S><T><L><F><R><A><D><H><P><F><L><F><V><I><R><K><D><D><I><I><L><F><S><G><K><V><S><C><P> | Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.<BOP> | O75635 |
Q9NYB0 | TE2IP_HUMAN | Repressor/activator protein 1 homolog | Homo | <M><A><E><A><M><D><L><G><K><D><P><N><G><P><T><H><S><S><T><L><F><V><R><D><D><G><S><S><M><S><F><Y><V><R><P><S><P><A><K><R><R><L><S><T><L><I><L><H><G><G><G><T><V><C><R><V><Q><E><P><G><A><V><L><L><A><Q><P><G><E><A><L><A><E><A><S><G><D><F><I><S><T><Q><Y><I><L><D><C><V><E><R><N><E><R><L><E><L><E><A><Y><R><L><G><P><A><S><A><A><D><T><G><S><E><A><K><P><G><A><L><A><E><G><A><A><E><P><E><P><Q><R><H><A><G><R><I><A><F><T><D><A><D><D><V><A><I><L><T><Y><V><K><E><N><A><R><S><P><S><S><V><T><G><N><A><L><W><K><A><M><E><K><S><S><L><T><Q><H><S><W><Q><S><L><K><D><R><Y><L><K><H><L><R><G><Q><E><H><K><Y><L><L><G><D><A><P><V><S><P><S><S><Q><K><L><K><R><K><A><E><E><D><P><E><A><A><D><S><G><E><P><Q><N><K><R><T><P><D><L><P><E><E><E><Y><V><K><E><E><I><Q><E><N><E><E><A><V><K><K><M><L><V><E><A><T><R><E><F><E><E><V><V><V><D><E><S><P><P><D><F><E><I><H><I><T><M><C><D><D><D><P><P><T><P><E><E><D><S><E><T><Q><P><D><E><E><E><E><E><E><E><E><K><V><S><Q><P><E><V><G><A><A><I><K><I><I><R><Q><L><M><E><K><F><N><L><D><L><S><T><V><T><Q><A><F><L><K><N><S><G><E><L><E><A><T><S><A><F><L><A><S><G><Q><R><A><D><G><Y><P><I><W><S><R><Q><D><D><I><D><L><Q><K><D><D><E><D><T><R><E><A><L><V><K><K><F><G><A><Q><N><V><A><R><R><I><E><F><R><K><K> | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate | Q9NYB0 |
Q99880 | H2B1L_HUMAN | Histone H2B.c | Homo | <M><P><E><L><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><S><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | Q99880 |
Q9NRP4 | SDHF3_HUMAN | Succinate dehydrogenase assembly factor 3, mitochondrial | Homo | <M><P><G><R><H><V><S><R><V><R><A><L><Y><K><R><V><L><Q><L><H><R><V><L><P><P><D><L><K><S><L><G><D><Q><Y><V><K><D><E><F><R><R><H><K><T><V><G><S><D><E><A><Q><R><F><L><Q><E><W><E><V><Y><A><T><A><L><L><Q><Q><A><N><E><N><R><Q><N><S><T><G><K><A><C><F><G><T><F><L><P><E><E><K><L><N><D><F><R><D><E><Q><I><G><Q><L><Q><E><L><M><Q><E><A><T><K><P><N><R><Q><F><S><I><S><E><S><M><K><P><K><F> | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.<BOP> | Q9NRP4 |
Q00604 | NDP_HUMAN | X-linked exudative vitreoretinopathy 2 protein | Homo | <M><R><K><H><V><L><A><A><S><F><S><M><L><S><L><L><V><I><M><G><D><T><D><S><K><T><D><S><S><F><I><M><D><S><D><P><R><R><C><M><R><H><H><Y><V><D><S><I><S><H><P><L><Y><K><C><S><S><K><M><V><L><L><A><R><C><E><G><H><C><S><Q><A><S><R><S><E><P><L><V><S><F><S><T><V><L><K><Q><P><F><R><S><S><C><H><C><C><R><P><Q><T><S><K><L><K><A><L><R><L><R><C><S><G><G><M><R><L><T><A><T><Y><R><Y><I><L><S><C><H><C><E><E><C><N><S> | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.<BOP> | Q00604 |
Q9BZI7 | REN3B_HUMAN | Up-frameshift suppressor 3 homolog on chromosome X | Homo | <M><K><E><E><K><E><H><R><P><K><E><K><R><V><T><L><L><T><P><A><G><A><T><G><S><G><G><G><T><S><G><D><S><S><K><G><E><D><K><Q><D><R><N><K><E><K><K><E><A><L><S><K><V><V><I><R><R><L><P><P><T><L><T><K><E><Q><L><Q><E><H><L><Q><P><M><P><E><H><D><Y><F><E><F><F><S><N><D><T><S><L><Y><P><H><M><Y><A><R><A><Y><I><N><F><K><N><Q><E><D><I><I><L><F><R><D><R><F><D><G><Y><V><F><L><D><N><K><G><Q><E><Y><P><A><I><V><E><F><A><P><F><Q><K><A><A><K><K><K><T><K><K><R><D><T><K><V><G><T><I><D><D><D><P><E><Y><R><K><F><L><E><S><Y><A><T><D><N><E><K><M><T><S><T><P><E><T><L><L><E><E><I><E><A><K><N><R><E><L><I><A><K><K><T><T><P><L><L><S><F><L><K><N><K><Q><R><M><R><E><E><K><R><E><E><R><R><R><R><E><I><E><R><K><R><Q><R><E><E><E><R><R><K><W><K><E><E><E><K><R><K><R><K><D><I><E><K><L><K><K><I><D><R><I><P><E><R><D><K><L><K><D><E><P><K><I><K><V><H><R><F><L><L><Q><A><V><N><Q><K><N><L><L><K><K><P><E><K><G><D><E><K><E><L><D><K><R><E><K><A><K><K><L><D><K><E><N><L><S><D><E><R><A><S><G><Q><S><C><T><L><P><K><R><S><D><S><E><L><K><D><E><K><P><K><R><P><E><D><E><S><G><R><D><Y><R><E><R><E><R><E><Y><E><R><D><Q><E><R><I><L><R><E><R><E><R><L><K><R><Q><E><E><E><R><R><R><Q><K><E><R><Y><E><K><E><K><T><F><K><R><K><E><E><E><M><K><K><E><K><D><T><L><R><D><K><G><K><K><A><E><S><T><E><S><I><G><S><S><E><K><T><E><K><K><E><E><V><V><K><R><D><R><I><R><N><K><D><R><P><A><M><Q><L><Y><Q><P><G><A><R><S><R><N><R><L><C><P><P><D><D><S><T><K><S><G><D><S><A><A><E><R><K><Q><E><S><G><I><S><H><R><K><E><G><G><E><E> | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.<BOP> | Q9BZI7 |
O95196 | CSPG5_HUMAN | Neuroglycan C | Homo | <M><G><R><A><G><G><G><G><P><G><R><G><P><P><P><L><L><L><F><L><G><A><A><L><V><L><A><S><G><A><V><P><A><R><E><A><G><S><A><V><E><A><E><E><L><V><K><G><S><P><A><W><E><P><P><A><N><D><T><R><E><E><A><G><P><P><A><A><G><E><D><E><A><S><W><T><A><P><G><G><E><L><A><G><P><E><E><V><L><Q><E><S><A><A><V><T><G><T><A><W><L><E><A><D><S><P><G><L><G><G><V><T><A><E><A><G><S><G><D><A><Q><A><L><P><A><T><L><Q><A><P><H><E><V><L><G><Q><S><I><M><P><P><A><I><P><E><A><T><E><A><S><G><P><P><S><P><T><P><G><D><K><L><S><P><A><S><E><L><P><K><E><S><P><L><E><V><W><L><N><L><G><G><S><T><P><D><P><Q><G><P><E><L><T><Y><P><F><Q><G><T><L><E><P><Q><P><A><S><D><I><I><D><I><D><Y><F><E><G><L><D><G><E><G><R><G><A><D><L><G><S><F><P><G><S><P><G><T><S><E><N><H><P><D><T><E><G><E><T><P><S><W><S><L><L><D><L><Y><D><D><F><T><P><F><D><E><S><D><F><Y><P><T><T><S><F><Y><D><D><L><D><E><E><E><E><E><E><E><D><D><K><D><A><V><G><G><G><D><L><E><D><E><N><E><L><L><V><P><T><G><K><P><G><L><G><P><G><T><G><Q><P><T><S><R><W><H><A><V><P><P><Q><H><T><L><G><S><V><P><G><S><S><I><A><L><R><P><R><P><G><E><P><G><R><D><L><A><S><S><E><N><G><T><E><C><R><S><G><F><V><R><H><N><G><S><C><R><S><V><C><D><L><F><P><S><Y><C><H><N><G><G><Q><C><Y><L><V><E><N><I><G><A><F><C><R><C><N><T><Q><D><Y><I><W><H><K><G><M><R><C><E><S><I><I><T><D><F><Q><V><M><C><V><A><V><G><S><A><A><L><V><L><L><L><L><F><M><M><T><V><F><F><A><K><K><L><Y><L><L><K><T><E><N><T><K><L><R><R><T><N><K><F><R><T><P><S><E><L><H><N><D><N><F><S><L><S><T><I><A><E><G><S><H><P><N><V><R><K><L><C><N><T><P><R><T><S><S><P><H><A><R><A><L><A><H><Y><D><N><V><I><C><Q><D><D><P><S><A><P><H><K><I><Q><E><V><L><K><S><C><L><K><E><E><E><S><F><N><I><Q><N><S><M><S><P><K><L><E><G><G><K><G><D><Q><A><D><L><D><V><N><C><L><Q><N><N><L><T> | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.<BOP> | O95196 |
P0DPK3 | NT2NB_HUMAN | Notch homolog 2 N-terminal-like protein B | Homo | <M><P><A><L><R><P><A><L><L><W><A><L><L><A><L><W><L><C><C><A><T><P><A><H><A><L><Q><C><R><D><G><Y><E><P><C><V><N><E><G><M><C><V><T><Y><H><N><G><T><G><Y><C><K><C><P><E><G><F><L><G><E><Y><C><Q><H><R><D><P><C><E><K><N><R><C><Q><N><G><G><T><C><V><A><Q><A><M><L><G><K><A><T><C><R><C><A><S><G><F><T><G><E><D><C><Q><Y><S><T><S><H><P><C><F><V><S><R><P><C><L><N><G><G><T><C><H><M><L><S><R><D><T><Y><E><C><T><C><Q><V><G><F><T><G><K><E><C><Q><W><T><D><A><C><L><S><H><P><C><A><N><G><S><T><C><T><T><V><A><N><Q><F><S><C><K><C><L><T><G><F><T><G><Q><K><C><E><T><D><V><N><E><C><D><I><P><G><H><C><Q><H><G><G><I><C><L><N><L><P><G><S><Y><Q><C><Q><C><L><Q><G><F><T><G><Q><Y><C><D><S><L><Y><V><P><C><A><P><S><P><C><V><N><G><G><T><C><R><Q><T><G><D><F><T><F><E><C><N><C><L><P><E><T><V><R><R><G><T><E><L><W><E><R><D><R><E><V><W><N><G><K><E><H><D><E><N> | Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway . Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production . Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect . Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 . Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation .<BOP> | P0DPK3 |
Q8IZ08 | GP135_HUMAN | G-protein coupled receptor 135 | Homo | <M><E><E><P><Q><P><P><R><P><P><A><S><M><A><L><L><G><S><Q><H><S><G><A><P><S><A><A><G><P><P><G><G><T><S><S><A><A><T><A><A><V><L><S><F><S><T><V><A><T><A><A><L><G><N><L><S><D><A><S><G><G><G><T><A><A><A><P><G><G><G><G><L><G><G><S><G><A><A><R><E><A><G><A><A><V><R><R><P><L><G><P><E><A><A><P><L><L><S><H><G><A><A><V><A><A><Q><A><L><V><L><L><L><I><F><L><L><S><S><L><G><N><C><A><V><M><G><V><I><V><K><H><R><Q><L><R><T><V><T><N><A><F><I><L><S><L><S><L><S><D><L><L><T><A><L><L><C><L><P><A><A><F><L><D><L><F><T><P><P><G><G><S><A><P><A><A><A><A><G><P><W><R><G><F><C><A><A><S><R><F><F><S><S><C><F><G><I><V><S><T><L><S><V><A><L><I><S><L><D><R><Y><C><A><I><V><R><P><P><R><E><K><I><G><R><R><R><A><L><Q><L><L><A><G><A><W><L><T><A><L><G><F><S><L><P><W><E><L><L><G><A><P><R><E><L><A><A><A><Q><S><F><H><G><C><L><Y><R><T><S><P><D><P><A><Q><L><G><A><A><F><S><V><G><L><V><V><A><C><Y><L><L><P><F><L><L><M><C><F><C><H><Y><H><I><C><K><T><V><R><L><S><D><V><R><V><R><P><V><N><T><Y><A><R><V><L><R><F><F><S><E><V><R><T><A><T><T><V><L><I><M><I><V><F><V><I><C><C><W><G><P><Y><C><F><L><V><L><L><A><A><A><R><Q><A><Q><T><M><Q><A><P><S><L><L><S><V><V><A><V><W><L><T><W><A><N><G><A><I><N><P><V><I><Y><A><I><R><N><P><N><I><S><M><L><L><G><R><N><R><E><E><G><Y><R><T><R><N><V><D><A><F><L><P><S><Q><G><P><G><L><Q><A><R><S><R><S><R><L><R><N><R><Y><A><N><R><L><G><A><C><N><R><M><S><S><S><N><P><A><S><G><V><A><G><D><V><A><M><W><A><R><K><N><P><V><V><L><F><C><R><E><G><P><P><E><P><V><T><A><V><T><K><Q><P><K><S><E><A><G><D><T><S><L> | Orphan receptor. Has spontaneous activity for beta-arrestin recruitment . Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization .<BOP> | Q8IZ08 |
Q09013 | DMPK_HUMAN | Myotonic dystrophy protein kinase | Homo | <M><S><A><E><V><R><L><R><R><L><Q><Q><L><V><L><D><P><G><F><L><G><L><E><P><L><L><D><L><L><L><G><V><H><Q><E><L><G><A><S><E><L><A><Q><D><K><Y><V><A><D><F><L><Q><W><A><E><P><I><V><V><R><L><K><E><V><R><L><Q><R><D><D><F><E><I><L><K><V><I><G><R><G><A><F><S><E><V><A><V><V><K><M><K><Q><T><G><Q><V><Y><A><M><K><I><M><N><K><W><D><M><L><K><R><G><E><V><S><C><F><R><E><E><R><D><V><L><V><N><G><D><R><R><W><I><T><Q><L><H><F><A><F><Q><D><E><N><Y><L><Y><L><V><M><E><Y><Y><V><G><G><D><L><L><T><L><L><S><K><F><G><E><R><I><P><A><E><M><A><R><F><Y><L><A><E><I><V><M><A><I><D><S><V><H><R><L><G><Y><V><H><R><D><I><K><P><D><N><I><L><L><D><R><C><G><H><I><R><L><A><D><F><G><S><C><L><K><L><R><A><D><G><T><V><R><S><L><V><A><V><G><T><P><D><Y><L><S><P><E><I><L><Q><A><V><G><G><G><P><G><T><G><S><Y><G><P><E><C><D><W><W><A><L><G><V><F><A><Y><E><M><F><Y><G><Q><T><P><F><Y><A><D><S><T><A><E><T><Y><G><K><I><V><H><Y><K><E><H><L><S><L><P><L><V><D><E><G><V><P><E><E><A><R><D><F><I><Q><R><L><L><C><P><P><E><T><R><L><G><R><G><G><A><G><D><F><R><T><H><P><F><F><F><G><L><D><W><D><G><L><R><D><S><V><P><P><F><T><P><D><F><E><G><A><T><D><T><C><N><F><D><L><V><E><D><G><L><T><A><M><V><S><G><G><G><E><T><L><S><D><I><R><E><G><A><P><L><G><V><H><L><P><F><V><G><Y><S><Y><S><C><M><A><L><R><D><S><E><V><P><G><P><T><P><M><E><L><E><A><E><Q><L><L><E><P><H><V><Q><A><P><S><L><E><P><S><V><S><P><Q><D><E><T><A><E><V><A><V><P><A><A><V><P><A><A><E><A><E><A><E><V><T><L><R><E><L><Q><E><A><L><E><E><E><V><L><T><R><Q><S><L><S><R><E><M><E><A><I><R><T><D><N><Q><N><F><A><S><Q><L><R><E><A><E><A><R><N><R><D><L><E><A><H><V><R><Q><L><Q><E><R><M><E><L><L><Q><A><E><G><A><T><A><V><T><G><V><P><S><P><R><A><T><D><P><P><S><H><L><D><G><P><P><A><V><A><V><G><Q><C><P><L><V><G><P><G><P><M><H><R><R><H><L><L><L><P><A><R><V><P><R><P><G><L><S><E><A><L><S><L><L><L><F><A><V><V><L><S><R><A><A><A><L><G><C><I><G><L><V><A><H><A><G><Q><L><T><A><V><W><R><R><P><G><A><A><R><A><P> | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.<BOP> | Q09013 |
Q9H6K4 | OPA3_HUMAN | Optic atrophy 3 protein | Homo | <M><V><V><G><A><F><P><M><A><K><L><L><Y><L><G><I><R><Q><V><S><K><P><L><A><N><R><I><K><E><A><A><R><R><S><E><F><F><K><T><Y><I><C><L><P><P><A><Q><L><Y><H><W><V><E><M><R><T><K><M><R><I><M><G><F><R><G><T><V><I><K><P><L><N><E><E><A><A><A><E><L><G><A><E><L><L><G><E><A><T><I><F><I><V><G><G><G><C><L><V><L><E><Y><W><R><H><Q><A><Q><Q><R><H><K><E><E><E><Q><R><A><A><W><N><A><L><R><D><E><V><G><H><L><A><L><A><L><E><A><L><Q><A><Q><V><Q><A><A><P><P><Q><G><A><L><E><E><L><R><T><E><L><Q><E><V><R><A><Q><L><C><N><P><G><R><S><A><S><H><A><V><P><A><S><K><K> | May play some role in mitochondrial processes.<BOP> | Q9H6K4 |
Q7Z417 | NUFP2_HUMAN | Nuclear FMR1-interacting protein 2 | Homo | <M><E><E><K><P><G><Q><P><Q><P><Q><H><H><H><S><H><H><H><P><H><H><H><P><Q><Q><Q><Q><Q><Q><P><H><H><H><H><H><Y><Y><F><Y><N><H><S><H><N><H><H><H><H><H><H><H><Q><Q><P><H><Q><Y><L><Q><H><G><A><E><G><S><P><K><A><Q><P><K><P><L><K><H><E><Q><K><H><T><L><Q><Q><H><Q><E><T><P><K><K><K><T><G><Y><G><E><L><N><G><N><A><G><E><R><E><I><S><L><K><N><L><S><S><D><E><A><T><N><P><I><S><R><V><L><N><G><N><Q><Q><V><V><D><T><S><L><K><Q><T><V><K><A><N><T><F><G><K><A><G><I><K><T><K><N><F><I><Q><K><N><S><M><D><K><K><N><G><K><S><Y><E><N><K><S><G><E><N><Q><S><V><D><K><S><D><T><I><P><I><P><N><G><V><V><T><N><N><S><G><Y><I><T><N><G><Y><M><G><K><G><A><D><N><D><G><S><G><S><E><S><G><Y><T><T><P><K><K><R><K><A><R><R><N><S><A><K><G><C><E><N><L><N><I><V><Q><D><K><I><M><Q><Q><E><T><S><V><P><T><L><K><Q><G><L><E><T><F><K><P><D><Y><S><E><Q><K><G><N><R><V><D><G><S><K><P><I><W><K><Y><E><T><G><P><G><G><T><S><R><G><K><P><A><V><G><D><M><L><R><K><S><S><D><S><K><P><G><V><S><S><K><K><F><D><D><R><P><K><G><K><H><A><S><A><V><A><S><K><E><D><S><W><T><L><F><K><P><P><P><V><F><P><V><D><N><S><S><A><K><I><V><P><K><I><S><Y><A><S><K><V><K><E><N><L><N><K><T><I><Q><N><S><S><V><S><P><T><S><S><S><S><S><S><S><S><T><G><E><T><Q><T><Q><S><S><S><R><L><S><Q><V><P><M><S><A><L><K><S><V><T><S><A><N><F><S><N><G><P><V><L><A><G><T><D><G><N><V><Y><P><P><G><G><Q><P><L><L><T><T><A><A><N><T><L><T><P><I><S><S><G><T><D><S><V><L><Q><D><M><S><L><T><S><A><A><V><E><Q><I><K><T><S><L><F><I><Y><P><S><N><M><Q><T><M><L><L><S><T><A><Q><V><D><L><P><S><Q><T><D><Q><Q><N><L><G><D><I><F><Q><N><Q><W><G><L><S><F><I><N><E><P><S><A><G><P><E><T><V><T><G><K><S><S><E><H><K><V><M><E><V><T><F><Q><G><E><Y><P><A><T><L><V><S><Q><G><A><E><I><I><P><S><G><T><E><H><P><V><F><P><K><A><Y><E><L><E><K><R><T><S><P><Q><V><L><G><S><I><L><K><S><G><T><T><S><E><S><G><A><L><S><L><E><P><S><H><I><G><D><L><Q><K><A><D><T><S><S><Q><G><A><L><V><F><L><S><K><D><Y><E><I><E><S><Q><N><P><L><A><S><P><T><N><T><L><L><G><S><A><K><E><Q><R><Y><Q><R><G><L><E><R><N><D><S><W><G><S><F><D><L><R><A><A><I><V><Y><H><T><K><E><M><E><S><I><W><N><L><Q><K><Q><D><P><K><R><I><I><T><Y><N><E><A><M><D><S><P><D><Q> | Binds RNA.<BOP> | Q7Z417 |
A0A0C4DH26 | KVD41_HUMAN | Probable non-functional immunoglobulin kappa variable 6D-41 | Homo | <M><V><S><P><L><Q><F><L><R><L><L><L><L><W><V><P><A><S><R><G><D><V><V><M><T><Q><S><P><A><F><L><S><V><T><P><G><E><K><V><T><I><T><C><Q><A><S><E><G><I><G><N><Y><L><Y><W><Y><Q><Q><K><P><D><Q><A><P><K><L><L><I><K><Y><A><S><Q><S><I><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><F><T><I><S><S><L><E><A><E><D><A><A><T><Y><Y><C><Q><Q><G><N><K><H><P> | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection | A0A0C4DH26 |
P50895 | BCAM_HUMAN | Lutheran blood group glycoprotein | Homo | <M><E><P><P><D><A><P><A><Q><A><R><G><A><P><R><L><L><L><L><A><V><L><L><A><A><H><P><D><A><Q><A><E><V><R><L><S><V><P><P><L><V><E><V><M><R><G><K><S><V><I><L><D><C><T><P><T><G><T><H><D><H><Y><M><L><E><W><F><L><T><D><R><S><G><A><R><P><R><L><A><S><A><E><M><Q><G><S><E><L><Q><V><T><M><H><D><T><R><G><R><S><P><P><Y><Q><L><D><S><Q><G><R><L><V><L><A><E><A><Q><V><G><D><E><R><D><Y><V><C><V><V><R><A><G><A><A><G><T><A><E><A><T><A><R><L><N><V><F><A><K><P><E><A><T><E><V><S><P><N><K><G><T><L><S><V><M><E><D><S><A><Q><E><I><A><T><C><N><S><R><N><G><N><P><A><P><K><I><T><W><Y><R><N><G><Q><R><L><E><V><P><V><E><M><N><P><E><G><Y><M><T><S><R><T><V><R><E><A><S><G><L><L><S><L><T><S><T><L><Y><L><R><L><R><K><D><D><R><D><A><S><F><H><C><A><A><H><Y><S><L><P><E><G><R><H><G><R><L><D><S><P><T><F><H><L><T><L><H><Y><P><T><E><H><V><Q><F><W><V><G><S><P><S><T><P><A><G><W><V><R><E><G><D><T><V><Q><L><L><C><R><G><D><G><S><P><S><P><E><Y><T><L><F><R><L><Q><D><E><Q><E><E><V><L><N><V><N><L><E><G><N><L><T><L><E><G><V><T><R><G><Q><S><G><T><Y><G><C><R><V><E><D><Y><D><A><A><D><D><V><Q><L><S><K><T><L><E><L><R><V><A><Y><L><D><P><L><E><L><S><E><G><K><V><L><S><L><P><L><N><S><S><A><V><V><N><C><S><V><H><G><L><P><T><P><A><L><R><W><T><K><D><S><T><P><L><G><D><G><P><M><L><S><L><S><S><I><T><F><D><S><N><G><T><Y><V><C><E><A><S><L><P><T><V><P><V><L><S><R><T><Q><N><F><T><L><L><V><Q><G><S><P><E><L><K><T><A><E><I><E><P><K><A><D><G><S><W><R><E><G><D><E><V><T><L><I><C><S><A><R><G><H><P><D><P><K><L><S><W><S><Q><L><G><G><S><P><A><E><P><I><P><G><R><Q><G><W><V><S><S><S><L><T><L><K><V><T><S><A><L><S><R><D><G><I><S><C><E><A><S><N><P><H><G><N><K><R><H><V><F><H><F><G><T><V><S><P><Q><T><S><Q><A><G><V><A><V><M><A><V><A><V><S><V><G><L><L><L><L><V><V><A><V><F><Y><C><V><R><R><K><G><G><P><C><C><R><Q><R><R><E><K><G><A><P><P><P><G><E><P><G><L><S><H><S><G><S><E><Q><P><E><Q><T><G><L><L><M><G><G><A><S><G><G><A><R><G><G><S><G><G><F><G><D><E><C> | Laminin alpha-5 receptor. May mediate intracellular signaling.<BOP> | P50895 |
Q6DKI2 | LEG9C_HUMAN | Galectin-9-like protein B | Homo | <M><A><F><S><G><C><Q><A><P><Y><L><S><P><A><V><P><F><S><G><T><I><Q><G><G><L><Q><D><G><F><Q><I><T><V><N><G><A><V><L><S><C><S><G><T><R><F><A><V><D><F><Q><T><G><F><S><G><N><D><I><A><F><H><F><N><P><R><F><E><D><G><G><Y><V><V><C><N><T><R><Q><K><G><T><W><G><P><E><E><R><K><M><H><M><P><F><Q><K><G><M><P><F><D><L><C><F><L><V><Q><S><S><D><F><K><V><M><V><N><G><S><L><F><V><Q><Y><F><H><R><V><P><F><H><R><V><D><T><I><S><V><N><G><S><V><Q><L><S><Y><I><S><F><Q><N><P><R><A><V><P><V><Q><P><A><F><S><T><V><P><F><S><Q><P><V><C><F><P><P><R><P><R><G><R><R><Q><K><P><P><S><V><R><P><A><N><P><A><P><I><T><Q><T><V><I><H><T><V><Q><S><A><S><G><Q><M><F><S><Q><T><P><A><I><P><P><M><M><Y><P><H><P><A><Y><P><M><P><F><I><T><T><I><P><G><G><L><Y><P><S><K><S><I><I><L><S><G><T><V><L><P><S><A><Q><R><F><H><I><N><L><C><S><G><S><H><I><A><F><H><M><N><P><R><F><D><E><N><A><V><V><R><N><T><Q><I><N><N><S><W><G><S><E><E><R><S><L><P><R><K><M><P><F><V><R><G><Q><S><F><S><V><W><I><L><C><E><A><H><C><L><K><V><A><V><D><G><Q><H><V><F><E><Y><Y><H><R><L><R><N><L><P><T><I><N><K><L><E><V><G><G><D><I><Q><L><T><H><V><Q><T> | Binds galactosides.<BOP> | Q6DKI2 |
Q9BSK1 | ZN577_HUMAN | Zinc finger protein 577 | Homo | <M><K><N><A><T><I><V><M><S><V><R><R><E><Q><G><S><S><S><G><E><G><S><L><S><F><E><D><V><A><V><G><F><T><R><E><E><W><Q><F><L><D><Q><S><Q><K><V><L><Y><K><E><V><M><L><E><N><Y><I><N><L><V><S><I><G><Y><R><G><T><K><P><D><S><L><F><K><L><E><Q><G><E><P><P><G><I><A><E><G><A><A><H><S><Q><I><C><P><G><F><V><I><Q><S><R><R><Y><A><G><K><D><S><D><A><F><G><G><Y><G><R><S><C><L><H><I><K><R><D><K><T><L><T><G><V><K><Y><H><R><C><V><K><P><S><S><P><K><S><Q><L><N><D><L><Q><K><I><C><A><G><G><K><P><H><E><C><S><V><C><G><R><A><F><S><R><K><A><Q><L><I><Q><H><Q><R><T><E><R><G><E><K><P><H><G><C><G><E><C><G><K><T><F><M><R><K><I><Q><L><T><E><H><Q><R><T><H><T><G><E><K><P><H><E><C><S><E><C><G><K><A><F><S><R><K><S><Q><L><M><V><H><Q><R><T><H><T><G><E><K><P><Y><R><C><S><K><C><G><K><A><F><S><R><K><C><R><L><N><R><H><Q><R><S><H><T><G><E><K><L><Y><G><C><S><V><C><G><K><A><F><S><Q><K><A><Y><L><T><A><H><Q><R><L><H><T><G><D><K><P><Y><K><C><S><D><C><G><R><T><F><Y><F><K><S><D><L><T><R><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><E><K><A><F><R><S><K><S><K><L><I><Q><H><Q><R><T><H><T><G><E><R><P><Y><S><C><R><E><C><G><K><A><F><A><H><M><S><V><L><I><K><H><E><K><T><H><I><R><E><T><A><I><N><S><L><T><V><E><K><P><S><S><R><S><H><T><S><L><Y><M><S><E><L><I><Q><E><Q><K><T><V><N><T><V><P><I><E><M><P><S><S><G><T><P><P><L><L><N><K><S><E><R><L><V><G><R><N><V><V><I><V><E><Q><P><F><P><R><N><Q><A><F><V><V><N><Q><E><F><E><Q><R><I><S><L><T><N><E><V><N><V><A><P><S><V><I><N><Y><I><L><Y><L><T><D><I><V><S><E> | May be involved in transcriptional regulation.<BOP> | Q9BSK1 |
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