title stringlengths 4 66 | document stringlengths 136 50.2k | aspect stringlengths 3 98 | aspect_sents sequencelengths 1 223 | summary stringlengths 12 2.68k | top_sentences_sentence stringlengths 136 7.06k | summary1 stringlengths 1 1.5k | index int64 389 389 |
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Classical complement pathway | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | Complement cascade | [
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] | The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM.
Following activation, a series of proteins are recruited to generate C3 ... | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | **Activation**: Antigen-antibody complexes or pathogens bind to C1q, triggering a conformational change and activating C1r.
**Step 1**: C1r cleaves and activates C1s.
**Step 2**: C1s cleaves C4 into C4a and C4b; C4b binds to pathogen surfaces.
**Step 3**: C2 binds to C4b, forming C4bC2b (C3-convertase).
**Step 4**:... | 389 |
Classical complement pathway | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | Complement cascade ; Initiation | [
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] | The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM.
Following activation, a series of proteins are recruited to generate C3 convertase (C4b2b, historically referred C4b2a), which cleaves the C3 protein. | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | **Initiation**: Antigen-antibody complexes or pathogen surfaces bind to C1q, triggering conformational changes and activating the serine protease C1r.
**Classical Pathway**:
1. C1r activates C1s, which cleaves C4 into C4a and C4b.
2. C4b binds to pathogen surfaces and acts as a receptor for C2.
3. C2 is cleaved by C1... | 389 |
Classical complement pathway | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | Complement cascade ; Formation of C5 convertase and MAC | [
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] | The C3b component of the cleaved C3 binds to C3 convertase (C4b2b) to generate C5 convertase (C4b2b3b), which cleaves the C5 protein. The membrane attack complex creates a pore on the target cell's membrane, inducing cell lysis and death. | The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex. The c... | **Complement Cascade:**
* C4b binds to the pathogen surface or antigen-antibody immune complex
* C2 binds to C4b, forming C4bC2b (C3-convertase)
* C3-convertase cleaves multiple C3 molecules into C3a and C3b
* C3b binds to C4b2b, forming C5 convertase (C4b2b3b)
* C5 convertase cleaves C5 into C5a and C5b
* C5b interac... | 389 |
Cycle of the Werewolf | The story is set in the fictional town of Tarker's Mills, Maine. Each chapter is a month on the calendar. A werewolf is viciously killing local citizens at each full moon, and the otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, a 10 year-old boy in a wheelchair. The story goes bac... | Synopsis | [
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] | It tells the story of a werewolf haunting a small town as the moon turns full once every month. | The story is set in the fictional town of Tarker's Mills, Maine. Each chapter is a month on the calendar. A werewolf is viciously killing local citizens at each full moon, and the otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, a 10 year-old boy in a wheelchair. The story goes bac... | The story takes place in the fictional town of Tarker's Mills, Maine, and follows the events of a werewolf attack every full moon. The protagonist, 10-year-old Marty Coslaw, who is confined to a wheelchair, becomes entangled in the mystery when he is attacked by the werewolf in July. As the story unfolds, Marty discove... | 389 |
Cycle of the Werewolf | The story is set in the fictional town of Tarker's Mills, Maine. Each chapter is a month on the calendar. A werewolf is viciously killing local citizens at each full moon, and the otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, a 10 year-old boy in a wheelchair. The story goes bac... | Background | [
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] | Cycle of the Werewolf is a short horror novel by American writer Stephen King, featuring illustrations by comic-book artist Bernie Wrightson. | he sees Reverend Lowe wearing an eyepatch. However, Lowe doesn't recognize Marty, as his face is covered by a Yoda mask. Marty, whose family is Catholic, never attend services at Lowe's church, which is why he didn't work out the werewolf's identity sooner. Over the next few weeks, Marty sends the pastor anonymous lett... | The story "Cycle of the Werewolf" by Stephen King originated as a calendar project with illustrations by Bernie Wrightson. Each month featured a drawing accompanied by a short vignette written by King. However, King found the format limiting and decided to expand the story into a short novel, which was published in 198... | 389 |
Cycle of the Werewolf | The story is set in the fictional town of Tarker's Mills, Maine. Each chapter is a month on the calendar. A werewolf is viciously killing local citizens at each full moon, and the otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, a 10 year-old boy in a wheelchair. The story goes bac... | Reception | [
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] | Each chapter is a short story unto itself. | he sees Reverend Lowe wearing an eyepatch. However, Lowe doesn't recognize Marty, as his face is covered by a Yoda mask. Marty, whose family is Catholic, never attend services at Lowe's church, which is why he didn't work out the werewolf's identity sooner. Over the next few weeks, Marty sends the pastor anonymous lett... | * Marty Coslaw: The protagonist, a 10-year-old paraplegic, receives sympathy and attention from his family and others due to his disability.
* Reverend Lester Lowe: Respected and admired by the community as a pillar of society, but struggles with his own dark secret as a werewolf.
* Nan Coslaw: Marty's mother, tries to... | 389 |
Cycle of the Werewolf | The story is set in the fictional town of Tarker's Mills, Maine. Each chapter is a month on the calendar. A werewolf is viciously killing local citizens at each full moon, and the otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, a 10 year-old boy in a wheelchair. The story goes bac... | Film adaptation | [
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] | King also wrote the screenplay for its film adaptation, "Silver Bullet" (1985). | he sees Reverend Lowe wearing an eyepatch. However, Lowe doesn't recognize Marty, as his face is covered by a Yoda mask. Marty, whose family is Catholic, never attend services at Lowe's church, which is why he didn't work out the werewolf's identity sooner. Over the next few weeks, Marty sends the pastor anonymous lett... | The novella "Cycle of the Werewolf" was adapted into a film called "Silver Bullet" in 1985. The movie starred Corey Haim as Marty, Everett McGill as Reverend Lowe, Gary Busey as Marty's uncle, and others. The film received mixed reviews but has since gained cult status in the US after regular TV appearances. A special ... | 389 |
Arclight (comics) | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | Publication history | [
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] | Arclight (Philippa Sontag) is a mutant supervillain appearing in American comic books published by Marvel Comics. Created by writer Chris Claremont and artist John Romita Jr., she is a former military officer who later becomes an assassin. She is primarily known as a member the original Marauders team, a group of mutan... | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | * First appearance: Uncanny X-Men #210 (October 1986)
* Created by: Chris Claremont and John Romita Jr.
* Original storyline: "Mutant Massacre” crossover
* Subsequent appearances:
+ Captain America (vol. 1) as a member of the Femizons team
+ Various X-Men stories as a member of the Marauders
+ “Dawn of X” event (201... | 389 |
Arclight (comics) | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | Fictional character biography | [
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] | As a Marauder, she has often fought the X-Men as well as related teams and heroes such as X-Factor and X-Force. Like many of the Marauders, Arclight has been killed in battle more than once, only to be revived each time by Sinister through advanced cloning techniques. | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | **Name:** Philipa Sontag (aka Arclight)
**Background:** Veteran of the Siancong War, a conflict that replaced the Vietnam War in Marvel Comics' revised canon.
**Powers:** Mutant abilities include generating seismic force from her hands, causing shockwaves and tremors; superhuman strength, stamina, and resistance to i... | 389 |
Arclight (comics) | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | In other media | [
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] | The character has made scattered minor appearances throughout other forms of media, such as animated television series and the film "X-Men: The Last Stand", in which she was portrayed by Omahyra Mota. | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | There is no mention of Arclight appearing in other media besides comic books. | 389 |
Arclight (comics) | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | In other media ; Film | [
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] | The character has made scattered minor appearances throughout other forms of media, such as animated television series and the film "X-Men: The Last Stand", in which she was portrayed by Omahyra Mota. | Arclight first appeared in silhouette in "Uncanny X-Men" #210 (Oct. 1986), then made her first full appearance the following month in issue #211 (Nov. 1986). Both issues served as chapters in the "Mutant Massacre" crossover that involved the X-Men, the spin-off team X-Factor, and other Marvel Comics heroes such as Thor... | Arclight has appeared in two films:
* "X-Men: The Last Stand" (2006) - Portrayed by Omahyra Mota, she is a member of the Omegas and joins Magneto's Brotherhood.
* "Deadpool" (no specific year mentioned) - Voiced by Chani Krich, she is a member of Mister Sinister's Marauders and is killed by Deadpool. | 389 |
Smart shop | Some governments do not tolerate smart shops in any form as a part of their crime prevention. For example, the Government of the Kingdom of Sweden with its zero tolerance drug policy, does not accept physical smart shops and has shut down every known Swedish online smart shop that have been selling pure research chemic... | Typical products specialization | [
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] | A smart shop (or smartshop) is a retail establishment that specializes in the sale of psychoactive substances, usually including psychedelics, as well as related literature and paraphernalia. | The sale of synthetic drugs not explicitly approved as food, supplements or medicines is illegal in some of them. For example, in the Netherlands it is dealt with by the relatively benign machinery of the "Warenautoriteit" (Commodities Authority) rather than in criminal law, as would be the case with controlled substan... | * Synthetic drugs not explicitly approved as food, supplements, or medicines
* Complement goods to psychoactive drugs, including:
+ Literature about illegal drugs or their manufacture
+ Paraphernalia (e.g. reagent kits for testing ecstasy purity)
+ Supplements to mitigate drug-related harm (e.g. vitamins, amino acid... | 389 |
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