INSTRUCTION stringclasses 1
value | INPUT stringlengths 735 7.34k | output stringclasses 148
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Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Among the anti-herpesvirus agents , aciclovir , valaciclovir , penciclovir , famciclovir , idoxuridine , trifluridine and brivudin are used in the treatment of herpes simplex virus and varicella-zoster virus infections , and ganciclovir , foscarnet , cidofovir , fomivirsen and maribavir ( the latter in th... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cycloserine ( i.p . ; a positive allosteric modulator of NMDA receptors ) , in alleviating the deficit in water maze spatial na... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) .", "spans": [{"span_id": 0, "text": "vincristine", "start": 66, "end": 77, "token_start": 9, "token_end": 10}, {"span_id": 1, "text": "cyclophosphamide", "start": 98, "end": ... | [{"class": "COMB", "spans": [0, 1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months .", "spans": [{"span_id": 0, "text": "cyclophosphamide", "start": 117, "end": 133, "token_start": 20, "toke... | [{"class": "COMB", "spans": [0, 1, 2, 3], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure .", "spans": [{"span_id": 0, "text": "propranolol", "start": 38, "end": 49, "token_start": 5, "token_end": 6}, {"span_id": 1, "text": "amiodarone", "start": 86, "end"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways .", "span... | [{"class": "COMB", "spans": [0, 1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly .", "spans": [{"span_id": 0, "text": "moxifloxacin", "start": 56, "end": 68, "token_start": 9, "token_end": 10}, {"span_id": 1, "text": "tobramycin", "start": 79, "end": 89, "token_start": 13... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) .", "spans": [{"span_id": 0, "text": "cetuximab", "start": 27, "end": 36, "token_start": 3, "token_end":... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines .", "spa... | [{"class": "COMB", "spans": [1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "However , anastrozole , exemestane and letrozole are associated with significantly fewer endometrial cancers , as well as venous and arterial vascular events , when compared with tamoxifen [ 9 , 10 ] .", "spans": [{"span_id": 0, "text": "anastrozole", "start": 10, "end": 21, "token_start": 2, "token_end":... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone .", "spans":... | [{"class": "POS", "spans": [0, 3], "is_context_needed": false}, {"class": "POS", "spans": [3, 4], "is_context_needed": false}, {"class": "POS", "spans": [1, 3], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "There was no cytotoxic effect of cisplatin , ifosfamide , and etoposide .", "spans": [{"span_id": 0, "text": "ifosfamide", "start": 45, "end": 55, "token_start": 8, "token_end": 9}, {"span_id": 1, "text": "etoposide", "start": 62, "end": 71, "token_start": 11, "token_end": 12}], "paragraph": "Overcoming C... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding beva... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent/refractory AML .", "spans": [{"span_id": 0, "text": "topotecan", "start"... | [{"class": "COMB", "spans": [1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The management of EP is challenging : no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first-line therapy .", "spans": [{"span_id": 0, "text": "cyclosporine", "start": 98, "end": 110, "token_start": 14, "token_end": 15}, {"span_id": 1, "text": "infliximab", "start"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "As single agents , curcumin and metformin are reported to exhibit chemopreventive properties , in vitro as well as in patients with oral cancer .", "spans": [{"span_id": 0, "text": "curcumin", "start": 19, "end": 27, "token_start": 4, "token_end": 5}, {"span_id": 1, "text": "metformin", "start": 32, "end"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Withdrawal rates were comparable to drug survival rates of other biological therapies and rates of adverse events were similar between brodalumab and ustekinumab .", "spans": [{"span_id": 0, "text": "brodalumab", "start": 135, "end": 145, "token_start": 20, "token_end": 21}, {"span_id": 1, "text": "usteki... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy .", "spans": [{"span_id": 0, "text": "mycophenolate", "start": 126, "end": 139, "token_start": 19, "token_end":... | [{"class": "POS", "spans": [0, 2], "is_context_needed": false}, {"class": "POS", "spans": [1, 2], "is_context_needed": false}, {"class": "POS", "spans": [2, 3], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel .", "spans": [{"span_id": 0, "text": "cyclophosphamide", "start": 124, "end": 140, "token_start... | [{"class": "COMB", "spans": [0, 1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease .", "spans": [{"span_id": 0, "text": "flutamide", "start": 81, "end... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer .", "spans": [{"span_id": 0, "text": "paclitaxel"... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents .",... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival .", "spans": [{"span_id": 0, "text": "apalutamide... | [{"class": "POS", "spans": [0, 2], "is_context_needed": false}, {"class": "POS", "spans": [1, 2], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "A screening method based on liquid chromatography-electrospray mass spectrometry for the simultaneous determination of six corticosteroids ( betamethasone 17-valerate BM 17-V , beclomethasone BC , beclomethasone dipropionate BCDP , methylprednisolone MP , budesonide BD , flunisolide FN ) was developed in ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant .", "spans": [{"span_id": 0, "text": "Ixazomib", "start": 48, "end": 56, "token_start": 8, "token_end": 9}, {"span_id": 1, "text": "Fulvestrant", "start": 73, "end"... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study .", "spans": [{"span_id": 0, "text": "Trastuzumab", "start": 66, "end": 77, "token_start": 8, "token_end": 9}, {"span_id": 1, "text": "Lapatinib", "start": 100, "... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow cl... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Furthermore , the overall response rate for docetaxel in the intent-to-treat population ( 42.5 % ) is superior to the response rate of either doxorubicin as second-line therapy ( 29.3 % ) or paclitaxel ( Taxol ; Bristol-Myers Squibb Oncology , Princeton , NJ ) when used as first- or second-line therapy ( ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Correlation of lidocaine induced changes in bladder capacity , compliance and number of uninhibited contractions with improvement on oral oxybutynin was 70.6 % , 64.3 % and 66.7 % , respectively .", "spans": [{"span_id": 0, "text": "lidocaine", "start": 15, "end": 24, "token_start": 2, "token_end": 3}, {"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) .", "spans": [{"span_id": 0, "text": "risedronate", "start": 14, "end": 25, "token_start": 2, "token_en... | [{"class": "POS", "spans": [1, 2], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The anti-CD22 immunoconjugate , inotuzumab ozogamicin , and the anti-CD19 BiTE ( \u00ae ) antibody , blinatumomab , have demonstrated impressive single agent activity in patients with relapsed or refractory B-ALL .", "spans": [{"span_id": 0, "text": "ozogamicin", "start": 43, "end": 53, "token_start": 5, ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 .", "spans... | [{"class": "NEG", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles .", "spans": [{"span_id": 0, "text": "paclitaxel", "start": 89, "end": 99, "tok... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "With regard to efficacy in metastatic disease , exemestane is superior to megestrol acetate after progression on tamoxifen .", "spans": [{"span_id": 0, "text": "exemestane", "start": 48, "end": 58, "token_start": 8, "token_end": 9}, {"span_id": 1, "text": "megestrol", "start": 74, "end": 83, "token_start"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Aim of the study was to measure plasma levels of specific miRNAs ( miRNA-223 , -150 , -21 and -126 ) after physician-driven cessation of chronic P2Y12 inhibition and to study differences in the expression levels of these miRNAs between the different oral P2Y12 inhibitors clopidogrel , prasugrel and ticagr... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks .", "spans": [{"span_id": 0, "text": "ramucirumab", "start": 27, "end": 38, "token_start": 3, "token_end": 4}, {"span_id": 1, "text": "dacarbazine", "start":... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo .", "spans": [{"span_id": 0, "text": "apigenin", "start": 119, "end"... | [{"class": "POS", "spans": [0, 2], "is_context_needed": true}, {"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The novel agents , romidepsin , pralatrexate , and brentuximab vedotin , are currently approved in the relapsed/refractory setting .", "spans": [{"span_id": 0, "text": "romidepsin", "start": 19, "end": 29, "token_start": 4, "token_end": 5}, {"span_id": 1, "text": "pralatrexate", "start": 32, "end": 44, "t... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE .", "spans": [{"span_id": 0, "text": "docetaxel", "start": 160, "end"... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat .", "spans": [{"span_id": 0, "text": "Gemcitabine", "start": 0, "end": 11, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "cyclosporine", "start": 17, "end": 29, "token_start": 2, "toke... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}, {"class": "POS", "spans": [0, 2], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells .", "spans": [{"span_id": 0, "text": "Erythropoietin", "start": 0, "end": 14, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "trastuzumab", "start": 61, "end": 7... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Both paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) and ifosfamide have been demonstrated to be active agents in patients with clinically defined platinum-refractory ovarian cancer .", "spans": [{"span_id": 0, "text": "paclitaxel", "start": 5, "end": 15, "token_start": 1, "token_end"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "All M. simiae complex species proved susceptible to clarithromycin and , to a lesser extent , rifabutin , clofazimine , streptomycin and moxifloxacin .", "spans": [{"span_id": 0, "text": "clarithromycin", "start": 52, "end": 66, "token_start": 8, "token_end": 9}, {"span_id": 1, "text": "rifabutin", "start... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Drug exposure of mesenchymal HCC cells showed higher resistance to the targeted therapeutic agents sorafenib and erlotinib as compared to epithelial HCC cells , which were slightly more resistant to cytostatic drugs .", "spans": [{"span_id": 0, "text": "sorafenib", "start": 99, "end": 108, "token_start": ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "To compare the effectiveness and safety of adalimumab and infliximab in biologic-na\u00efve patients with CD , in a nationwide register-based propensity score-matched cohort study in Denmark .", "spans": [{"span_id": 0, "text": "adalimumab", "start": 43, "end": 53, "token_start": 7, "token_end": 8}, {"spa... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Hematologic National Cancer Institute Common Toxicity Criteria grade 3 to 4 adverse events were more common with bendamustine than with chlorambucil ( occurring in 40 % v 19 % of patients ) .", "spans": [{"span_id": 0, "text": "bendamustine", "start": 113, "end": 125, "token_start": 17, "token_end": 18}, ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice .", "spans": [{"span_id": 0, "text": "diclofenac", "start": 29, "end": 39, "token_start": 5, "token_end": 6}, {"span_id": 1, "text": "octreo... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models .", "spans": [{"span_id": 0, "text": "Caspofungin", "start": 0, "end": 11, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "amphotericin", "start": 16, "end": 28, "token_start": 2,... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol .", "spans": [{"span_id": 0, "text": "meglumine", "start": 63, "end": 72, "token_start": 9, "token_end": 10}, {"span_id": 1, "text... | [{"class": "POS", "spans": [3, 4], "is_context_needed": false}, {"class": "POS", "spans": [1, 2, 5], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Haloperidol , carbamazepine and levomepromazine were then discontinued .", "spans": [{"span_id": 0, "text": "Haloperidol", "start": 0, "end": 11, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "carbamazepine", "start": 14, "end": 27, "token_start": 2, "token_end": 3}], "paragraph": "Pituitary m... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors .", "spans": [{"span_id": 0, "text": "quinidine... | [{"class": "NEG", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The mean duration of total ( i.v . and oral ) therapy was significantly shorter for the azithromycin group than for the cefuroxime group ( 6.2 days vs 10.1 days ) .", "spans": [{"span_id": 0, "text": "azithromycin", "start": 88, "end": 100, "token_start": 17, "token_end": 18}, {"span_id": 1, "text": "cefu... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E/C ) - with respect to the standard combination ( EC ) .", "spans": [{"span... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for use in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive , HER2-negative a... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine .", "spans": [{"span_id": 0, "text": "estramustine", "start": 26, "end": 38, "token_start": 4, "token_end": 5}, {"span_id": 1, "text": "cyproterone", "start": 51, "end": 62, "token_start": 7, "token_end"... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}, {"class": "POS", "spans": [2, 3], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge .", "spans": [{"span_id": 0, "text": "halothane", "start": 150, "end": 159, "token_start": 20, "token_end": 21}, {"s... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer .", "spans": [{"span_id": 0, "text": "Mitomycin", "start": 0, "end": 9, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "vinblastine", "start": 17, "end": 28, "token_start": 3, "token_end":... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects .", "spans": [{"span_id": 0, "text": "olmesartan", "start": 43, "end": 53, "token_start": 8, "tok... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide ... | [{"class": "POS", "spans": [0, 1, 2, 3], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma .", "spans": [{"span_id": 0, "t... | [{"class": "COMB", "spans": [1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Failure to sedate patients who might be aware of paralysis occurred in three of 25 succinylcholine and eight of 94 pancuronium uses .", "spans": [{"span_id": 0, "text": "succinylcholine", "start": 83, "end": 98, "token_start": 15, "token_end": 16}, {"span_id": 1, "text": "pancuronium", "start": 115, "end"... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Thirty-one isolates were classified as resistant to amprolium , 23 resistant to monensin , 10 resistant to diclazuril , and 6 resistant to clopidol .", "spans": [{"span_id": 0, "text": "amprolium", "start": 52, "end": 61, "token_start": 7, "token_end": 8}, {"span_id": 1, "text": "diclazuril", "start": 107... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention .", "spans": [{"span_id": 0, "text": "lidocaine", "start": 138, "end": 147, "token_start": 17, "token_end": 18},... | [{"class": "POS", "spans": [0, 1, 2], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin .", "spans": [{"span_id": 0, "text": "omega-3", "start": 22, "end": 29, "token_start": 3, "token_end": 4}, {"span_id": 1, "text": "niacin", "start... | [{"class": "POS", "spans": [0, 1, 2, 3, 4], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg/kg ) in Cycle 1 .", "spans": [{"span_id": 0, "text": "irinotecan", "start": 84, "end": 94, "token_star... | [{"class": "COMB", "spans": [0, 1, 2, 3, 4], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Patients received vinorelbine starting at 20 mg/m(2 ) ( to 25 mg/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression .", "spans": [{"span_id": 0, "text": "vinorelbine", "start": 18, "end":... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion .", "spans": [{"span_id": 0, "text": "Dexamethasone", "start": 0, "end": 13, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "paclitaxel", "start": 46, "end": 56, "token_start": 6, "token_e... | [{"class": "COMB", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The first available studies demonstrate the value of these compounds with an improved prognosis of metastatic patients in combination with endocrine therapy ( palbociclib , ribociclib ) or in monotherapy ( abemaciclib ) .", "spans": [{"span_id": 0, "text": "palbociclib", "start": 159, "end": 170, "token_s... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective .", "spans": [{"span_id": 0, "text": "Flunarizine", "start": 0, "end": 11, "token_start": 0, "token_end": 1}, {"span_id": 1, "text": "diltiazem", "start": 110, "end": ... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates ( 9 itraconazole susceptible and 5 itraconazole resistant ) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore... | [{"class": "POS", "spans": [0, 1], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , plus rituximab ( R-INO ) every 3 weeks , up to six cycles , followed by high dose therapy and autologous stem cell transplant ( HDT-aSCT ) in patients with ... | [{"class": "COMB", "spans": [0, 2, 3], "is_context_needed": true}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin .", "spans": [{"span_id": 0, "text": "methylprednisolone", "start": 99, "end": 1... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}, {"class": "POS", "spans": [0, 1, 2], "is_context_needed": false}] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "The introduction of the selective serotonin reuptake inhibitors , moclobemide and mianserin has been a major advance in the treatment of depression , and is already leading to major shifts in the pattern of antidepressants prescribing .", "spans": [{"span_id": 0, "text": "moclobemide", "start": 66, "end":... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "Four of these had equivocal plasma levels of both norepinephrine and epinephrine , suggesting that overnight clonidine suppression may be of particular value when tumor secretion is intermittent or low .", "spans": [{"span_id": 0, "text": "epinephrine", "start": 69, "end": 80, "token_start": 11, "token_en... | [] | null |
Task Definition is as follows:INPUT: consist of a sentence, drug mentions within the sentence, and an enclosing context (e.g. paragraph or abstract).OUTPUT: a set of relations, each consisting of a set of participating drug spans and a relation label | {"sentence": "In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine .", "spans": [{"span_id": 0, "text": "ATGAM", "start": 43, "end": 48, "token_start": 6, "token_end": 7}, {"span_id": 1, "text": "tacrolimus", "start": 53,... | [{"class": "POS", "spans": [0, 1], "is_context_needed": false}] | null |
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