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d04863d | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 | {
"candidate_id": "var_s1",
"parent_id": "WT_SCFV",
"representation": "true_scfv",
"chain_B_scfv": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGNTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQDVHTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK",
"chain_C_HER2_ECD": "TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLSPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTATQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDSNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSIWKFPDEEGACQPCPIN",
"linker_sequence": "GGGGSGGGGSGGGGS",
"mutations_vs_wt": ["B:57 Y->N", "A:30 N->H"],
"mutations_vs_d70": [],
"scfv_aware_remap_splitter_required": true,
"linker_aware_contact_mask_required": true,
"source": "ProteinMPNN true scFv A30/B57 variation smoke (job 6a50b64d6d2b10c09d677a7b), sample 1",
"validation_status": "UNVALIDATED_PENDING_BOLTZ2",
"downstream_validation_required": true,
"allowed_archive_update": false,
"note": "ProteinMPNN-designed true scFv candidate; VH-(G4S)3-VL; 242 aa; linker intact; A30/B57 allowed mutations only; UNVALIDATED until Boltz2 + HER2 remap + scFv split + linker mask + C:591 + interface-quality validation passes"
}
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