File size: 2,149 Bytes
c6dcdf7 bfbb3fa c6dcdf7 bfbb3fa ec29521 18eda53 0780e1c 18eda53 bfbb3fa 18eda53 bfbb3fa 18eda53 bfbb3fa 18eda53 bfbb3fa |
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
---
license: mit
language:
- en
tags:
- biology
- single-cell
- scFM
- Drosophila
- foundation-model
- cell-type-annotation
---
<div align="start">
<img src="lemur-flaticon.png" alt="Lemur Icon" width="250">
<h1>Lemur: A Single-Cell Foundation Model for <em>Drosophila melanogaster</em> 🪰🔬</h1>
</div>
**Lemur** is a single-cell foundation model developed specifically for *Drosophila melanogaster*. It achieves fine-tuning-free cell-type annotation using two key innovations:
- **Comprehensive Pre-training:** Trained on an integrated whole-organism atlas with a unified cell-type annotation schema.
- **Hierarchical Decoding:** Employs a transformer-based hierarchical cell-type decoder to generate consistent predictions at multiple levels of granularity.
### Highlights ⚡️
- **Fine-Tuning-Free Annotation:** No extra training required on new datasets.
- **Robust Across Conditions:** Consistent performance across various tissue types, experimental conditions, and sequencing platforms.
- **Zero-Shot Batch-Effect Correction:** Automatically corrects batch effects without further adjustments.
- **Broad Applications:** Tailored for the fly research community with potential implications for aging and neurodegenerative disease studies in humans.
### Status & Availability 🚀
- **Model Weights:** Available now on the Hugging Face Hub 🏋🏻♂️.
- **Code:** Soon to be released. Stay tuned! 🔥👀
### Publication & Citation 📚🔗
We're excited to share our manuscript, *Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for* *Drosophila melanogaster*, which is now available as a preprint on [bioRxiv: 10.1101/123456](https://www.biorxiv.org/content/10.1101/123456)! 🚀✨
If you find our work helpful, please consider citing our preprint as follows:
```bibtex
@article{your_citation_key,
title={Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for *Drosophila melanogaster*},
author={Doe, John and Smith, Jane and Collaborators},
journal={bioRxiv},
year={2025},
doi={10.1101/123456}
}
``` |