🧬 Thoth-mini

Thoth-mini is a lightweight version of Thoth, designed for efficient and scalable biological protocol generation while retaining strong scientific reasoning ability.

• 📄 Paper: Unleashing Scientific Reasoning for Bio-experimental Protocol Generation via Structured Component-based Reward Mechanism (ICLR 2026)
• 🔗 GitHub: https://github.com/manglu097/Thoth
• 🤗 Dataset: https://huggingface.co/datasets/manglu3935/SciRecipe

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🔍 Model Overview

• Base model: Qwen3-4B
• Parameters: 4B
• GPU memory: ~8GB
• Primary task: Biological experimental protocol generation

Thoth-mini is trained with the same Sketch-and-Fill paradigm and SCORE reward mechanism as Thoth, offering a strong performance–efficiency trade-off.

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🧠 Output Format

<think>  reasoning and planning </think>
<key>    structured machine-readable steps </key>
<orc>    natural language protocol </orc>
<note>   optional safety notes </note>

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🚀 Usage

from transformers import AutoModelForCausalLM, AutoTokenizer

tokenizer = AutoTokenizer.from_pretrained("manglu3935/Thoth-mini")
model = AutoModelForCausalLM.from_pretrained("manglu3935/Thoth-mini")

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⚠️ Intended Use

For fast scientific reasoning experiments and scalable research deployment.
Generated protocols must be reviewed by qualified experts prior to laboratory execution.

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📖 Citation

@article{sun2025unleashing,
  title={Unleashing Scientific Reasoning for Bio-experimental Protocol Generation via Structured Component-based Reward Mechanism},
  author={Sun, Haoran and Jiang, Yankai and Tang, Zhenyu and others},
  journal={arXiv preprint arXiv:2510.15600},
  year={2025}
}