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Dec 12

Evidence Inference 2.0: More Data, Better Models

How do we most effectively treat a disease or condition? Ideally, we could consult a database of evidence gleaned from clinical trials to answer such questions. Unfortunately, no such database exists; clinical trial results are instead disseminated primarily via lengthy natural language articles. Perusing all such articles would be prohibitively time-consuming for healthcare practitioners; they instead tend to depend on manually compiled systematic reviews of medical literature to inform care. NLP may speed this process up, and eventually facilitate immediate consult of published evidence. The Evidence Inference dataset was recently released to facilitate research toward this end. This task entails inferring the comparative performance of two treatments, with respect to a given outcome, from a particular article (describing a clinical trial) and identifying supporting evidence. For instance: Does this article report that chemotherapy performed better than surgery for five-year survival rates of operable cancers? In this paper, we collect additional annotations to expand the Evidence Inference dataset by 25\%, provide stronger baseline models, systematically inspect the errors that these make, and probe dataset quality. We also release an abstract only (as opposed to full-texts) version of the task for rapid model prototyping. The updated corpus, documentation, and code for new baselines and evaluations are available at http://evidence-inference.ebm-nlp.com/.

  • 5 authors
·
May 8, 2020

SemEval-2023 Task 7: Multi-Evidence Natural Language Inference for Clinical Trial Data

This paper describes the results of SemEval 2023 task 7 -- Multi-Evidence Natural Language Inference for Clinical Trial Data (NLI4CT) -- consisting of 2 tasks, a Natural Language Inference (NLI) task, and an evidence selection task on clinical trial data. The proposed challenges require multi-hop biomedical and numerical reasoning, which are of significant importance to the development of systems capable of large-scale interpretation and retrieval of medical evidence, to provide personalized evidence-based care. Task 1, the entailment task, received 643 submissions from 40 participants, and Task 2, the evidence selection task, received 364 submissions from 23 participants. The tasks are challenging, with the majority of submitted systems failing to significantly outperform the majority class baseline on the entailment task, and we observe significantly better performance on the evidence selection task than on the entailment task. Increasing the number of model parameters leads to a direct increase in performance, far more significant than the effect of biomedical pre-training. Future works could explore the limitations of large models for generalization and numerical inference, and investigate methods to augment clinical datasets to allow for more rigorous testing and to facilitate fine-tuning. We envisage that the dataset, models, and results of this task will be useful to the biomedical NLI and evidence retrieval communities. The dataset, competition leaderboard, and website are publicly available.

  • 6 authors
·
May 4, 2023

Accelerated Bayesian Inference for Pulsar Timing Arrays: Normalizing Flows for Rapid Model Comparison Across Stochastic Gravitational-Wave Background Sources

The recent detection of nanohertz stochastic gravitational-wave backgrounds (SGWBs) by pulsar timing arrays (PTAs) promises unique insights into astrophysical and cosmological origins. However, traditional Markov Chain Monte Carlo (MCMC) approaches become prohibitively expensive for large datasets. We employ a normalizing flow (NF)-based machine learning framework to accelerate Bayesian inference in PTA analyses. For the first time, we perform Bayesian model comparison across SGWB source models in the framework of machine learning by training NF architectures on the PTA dataset (NANOGrav 15-year) and enabling direct evidence estimation via learned harmonic mean estimators. Our examples include 10 conventional SGWB source models such as supermassive black hole binaries, power-law spectrum, cosmic strings, domain walls, scalar-induced GWs, first-order phase transitions, and dual scenario/inflationary gravitational wave. Our approach jointly infers 20 red noise parameters and 2 SGWB parameters per model in sim 20\,hours (including training), compared to sim 10\,days with MCMC. Critically, the NF method preserves rigorous model selection accuracy, with small Hellinger distances (lesssim 0.3) relative to MCMC posteriors, and reproduces MCMC-based Bayes factors across all tested scenarios. This scalable technique for SGWB source comparison will be essential for future PTA expansions and next-generation arrays such as the SKA, offering orders-of-magnitude efficiency gains without sacrificing physical interpretability.

  • 2 authors
·
Apr 5

Generative Reasoning Recommendation via LLMs

Despite their remarkable reasoning capabilities across diverse domains, large language models (LLMs) face fundamental challenges in natively functioning as generative reasoning recommendation models (GRRMs), where the intrinsic modeling gap between textual semantics and collaborative filtering signals, combined with the sparsity and stochasticity of user feedback, presents significant obstacles. This work explores how to build GRRMs by adapting pre-trained LLMs, which achieves a unified understanding-reasoning-prediction manner for recommendation tasks. We propose GREAM, an end-to-end framework that integrates three components: (i) Collaborative-Semantic Alignment, which fuses heterogeneous textual evidence to construct semantically consistent, discrete item indices and auxiliary alignment tasks that ground linguistic representations in interaction semantics; (ii) Reasoning Curriculum Activation, which builds a synthetic dataset with explicit Chain-of-Thought supervision and a curriculum that progresses through behavioral evidence extraction, latent preference modeling, intent inference, recommendation formulation, and denoised sequence rewriting; and (iii) Sparse-Regularized Group Policy Optimization (SRPO), which stabilizes post-training via Residual-Sensitive Verifiable Reward and Bonus-Calibrated Group Advantage Estimation, enabling end-to-end optimization under verifiable signals despite sparse successes. GREAM natively supports two complementary inference modes: Direct Sequence Recommendation for high-throughput, low-latency deployment, and Sequential Reasoning Recommendation that first emits an interpretable reasoning chain for causal transparency. Experiments on three datasets demonstrate consistent gains over strong baselines, providing a practical path toward verifiable-RL-driven LLM recommenders.

  • 8 authors
·
Oct 23 1

Cross-Lingual Consistency: A Novel Inference Framework for Advancing Reasoning in Large Language Models

Chain-of-thought (CoT) has emerged as a critical mechanism for enhancing reasoning capabilities in large language models (LLMs), with self-consistency demonstrating notable promise in boosting performance. However, inherent linguistic biases in multilingual training corpora frequently cause semantic drift and logical inconsistencies, especially in sub-10B parameter LLMs handling complex inference tasks. To overcome these constraints, we propose the Cross-Lingual Consistency (CLC) framework, an innovative inference paradigm that integrates multilingual reasoning paths through majority voting to elevate LLMs' reasoning capabilities. Empirical evaluations on the CMATH dataset reveal CLC's superiority over the conventional self-consistency method, delivering 9.5%, 6.5%, and 6.0% absolute accuracy gains for DeepSeek-Math-7B-Instruct, Qwen2.5-Math-7B-Instruct, and Gemma2-9B-Instruct respectively. Expanding CLC's linguistic scope to 11 diverse languages implies two synergistic benefits: 1) neutralizing linguistic biases in multilingual training corpora through multilingual ensemble voting, 2) escaping monolingual reasoning traps by exploring the broader multilingual solution space. This dual benefits empirically enables more globally optimal reasoning paths compared to monolingual self-consistency baselines, as evidenced by the 4.1%-18.5% accuracy gains using Gemma2-9B-Instruct on the MGSM dataset.

  • 5 authors
·
Apr 2