Daily Papers

Astrocytes are increasingly recognized as active regulators of neural dynamics, yet their role in large-scale synchronization remains incompletely understood. Building on the discovery of breathing cluster synchronization in neuron-astrocyte networks, we investigate whether this phenomenon persists under more biologically realistic conditions by incorporating thermosensitive neuronal dynamics, intrinsic electric-field interactions, stochastic perturbations, and delayed astrocytic feedback. Through systematic numerical simulations of a network containing structurally symmetric neuronal subsets, we show that breathing clusters characterized by intermittent alternations between synchronized and desynchronized states, remain robust across a broad range of biophysical conditions. The results reveal a non-monotonic dependence on astrocytic attenuation and feedback parameters, with intermediate values maximizing rhythmic switching through a slow push-pull regulatory mechanism. Temperature and electric-field effects primarily modulate neuronal excitability and the tolerance of the breathing state to noise, while elevated stochastic perturbations progressively destabilize cluster coherence. In contrast, the phenomenon exhibits remarkable robustness to biologically realistic astrocytic delays. Importantly, our findings indicate that the emergence of breathing synchronization remains fundamentally governed by the interplay between network symmetry and astrocyte-mediated feedback, whereas temperature, electric fields, and noise act as modulators of its stability and temporal organization. These results establish breathing cluster synchronization as a robust organizing principle of astrocyte-regulated networks and provide a quantitative framework for understanding how glial regulation shapes cortical state-switching under realistic physiological conditions.

I introduce a novel mathematical framework integrating topological dynamics, operator algebras, and ergodic geometry to study lattices of asynchronous metric dynamical systems. Each node in the lattice carries an internal flow represented by a one-parameter family of operators, evolving on its own time scale. I formalize stratified state spaces capturing multiple levels of synchronized behavior, define an asynchronous evolution metric that quantifies phase-offset distances between subsystems, and characterize emergent coherent topologies arising when subsystems synchronize. Within this framework, I develop formal operators for the evolution of each subsystem and give precise conditions under which phase-aligned synchronization occurs across the lattice. The main results include: (1) the existence and uniqueness of coherent (synchronized) states under a contractive coupling condition, (2) stability of these coherent states and criteria for their emergence as a collective phase transition in a continuous operator topology, and (3) the influence of symmetries, with group-invariant coupling leading to flow-invariant synchrony subspaces and structured cluster dynamics. Proofs are given for each theorem, demonstrating full mathematical rigor. In a final section, I discuss hypothetical applications of this framework to symbolic lattice systems (e.g. subshifts), to invariant group actions on dynamical lattices, and to operator fields over stratified manifolds in the spirit of noncommutative geometry. Throughout, I write in the first person to emphasize the exploratory nature of this work. The paper avoids any reference to cosmology or observers, focusing instead on clean, formal mathematics suitable for a broad array of dynamical systems.

Collaborative generation, which coordinates multiple diffusion trajectories to extend the capabilities of pretrained priors, has emerged as a powerful paradigm for extending the applicability of diffusion models. Among existing approaches, diffusion synchronization provides a scenario-agnostic solution by introducing general guidance mechanisms. However, current synchronization approaches rely heavily on heuristics and still require task-specific tailoring, which limits their generalizability and performance. In this work, we mathematically derive a synchronization framework based on optimal control, providing a principled explanation of diffusion synchronization. During sampling, we optimize control variables to guide multiple trajectories toward coherent solutions while remaining close to the underlying diffusion prior. Our method operates entirely at test-time without additional training, thereby enabling broad applicability across diverse generation scenarios when combined with strong pretrained priors. We demonstrate consistent improvements over baselines on three representative collaborative generation tasks, covering a wide range of modalities and applications. Beyond performance gains, our work establishes a novel foundation for collaborative generation, opening a principled path toward extending pretrained generative models to new collaborative generation settings.

Modern large-scale language model pre-training relies heavily on the single program multiple data (SPMD) paradigm, which requires tight coupling across accelerators. Due to this coupling, transient slowdowns, hardware failures, and synchronization overhead stall the entire computation, wasting significant compute time at scale. While recent distributed methods like DiLoCo reduced communication bandwidth, they remained fundamentally synchronous and vulnerable to these system stalls. To address this, we introduce Decoupled DiLoCo, an evolution of the DiLoCo framework designed to break the lock-step synchronization barrier and go beyond SPMD to maximize training goodput. Decoupled DiLoCo partitions compute across multiple independent ``learners'' that execute local inner optimization steps. These learners asynchronously communicate parameter fragments to a central synchronizer, which circumvents failed or straggling learners by aggregating updates using a minimum quorum, an adaptive grace window, and dynamic token-weighted merging. Inspired by ``chaos engineering'', we achieve significantly improved training efficiency in failure-prone environments with millions of simulated chips with strictly zero global downtime, while maintaining competitive model performance across text and vision tasks, for both dense and mixture-of-expert architectures.

In heterogeneous networks of coupled oscillators, phase frustration typically prevents the emergence of synchronization in the Sakaguchi--Kuramoto (SK) model. In this study, we propose an analytical framework to overcome this barrier and induce complete synchronization at a specified small coupling value in oscillators governed by phase-frustrated bi-harmonic coupling. We derive an optimal set of natural frequencies that is robust against added noise and correlated with the network degree heterogeneity, along with the parameters involved in the bi-harmonic coupling function that lead to complete synchronization (r = 1). In addition, we find complete synchronization transitions accompanied by hysteresis in scale-free networks, indicating a first-order (discontinuous) phase transition, whereas Erdős--Rényi networks exhibit complete synchronization through a second-order (continuous) phase transition. Furthermore, we use the mean-field approximation in the presence of optimal frequencies to determine the critical coupling strength associated with the synchronization transition in the pure second-harmonic Sakaguchi--Kuramoto model. Here, the obtained optimal natural frequencies scale linearly with the node degree, and the critical coupling strength for the onset of synchronization is derived analytically from the self-consistent equations. In this specific regime, we observe a perfectly ordered two-cluster synchronized state. These findings remain robust for higher-order harmonic coupling schemes, as well as across a diverse range of synthetic and empirical networks, including scale-free, Erdős--Rényi, Zachary Karate Club, and the C.~elegans neural network, demonstrating their general applicability.

Dynamic MRI is a technique of acquiring a series of images continuously to follow the physiological changes over time. However, such fast imaging results in low resolution images. In this work, abdominal deformation model computed from dynamic low resolution images have been applied to high resolution image, acquired previously, to generate dynamic high resolution MRI. Dynamic low resolution images were simulated into different breathing phases (inhale and exhale). Then, the image registration between breathing time points was performed using the B-spline SyN deformable model and using cross-correlation as a similarity metric. The deformation model between different breathing phases were estimated from highly undersampled data. This deformation model was then applied to the high resolution images to obtain high resolution images of different breathing phases. The results indicated that the deformation model could be computed from relatively very low resolution images.

Human cognition emerges from coordinated spiking dynamics in distributed neural circuits, where information is encoded via both firing rates and precise spike timing determined by brain rhythms. Inspired by this notion, we propose a brain-inspired learning primitive in which cognition-level neural synchrony emerges through iterative bottom-up and top-down interactions between micro-scale dynamics of spiking neurons and a macro-scale mechanism of oscillatory synchronization. Specifically, we model each parcel (e.g., a cortical region or an image pixel) in the target system as a spiking neuron embedded in a predefined connectivity scaffold. Low-level information is encoded in a spatiotemporal domain, where neurons are selectively grouped and fire spontaneously over time through self-organized dynamics. In the bottom-up route, oscillatory synchronization is formed from past spiking activity accumulated over a finite memory window. Since brain dynamics operate in a regime of partial and transient synchronization rather than global phase locking, we model oscillatory coordination using a time-delayed synchronization formulation, which enables a top-down modulation of heterogeneous neural spiking for a large-scale distributed system. Together, we devise a spiking-by-synchronization neural network (S2-Net) that uses rhythmic timing as a control mechanism for efficient information processing. Promising results have been achieved across a broad range of tasks, including neural activity decoding, energy-efficient signal processing, temporal binding and semantic reasoning.

Achieving high synchronization in the synthesis of realistic, speech-driven talking head videos presents a significant challenge. A lifelike talking head requires synchronized coordination of subject identity, lip movements, facial expressions, and head poses. The absence of these synchronizations is a fundamental flaw, leading to unrealistic results. To address the critical issue of synchronization, identified as the ''devil'' in creating realistic talking heads, we introduce SyncTalk++, which features a Dynamic Portrait Renderer with Gaussian Splatting to ensure consistent subject identity preservation and a Face-Sync Controller that aligns lip movements with speech while innovatively using a 3D facial blendshape model to reconstruct accurate facial expressions. To ensure natural head movements, we propose a Head-Sync Stabilizer, which optimizes head poses for greater stability. Additionally, SyncTalk++ enhances robustness to out-of-distribution (OOD) audio by incorporating an Expression Generator and a Torso Restorer, which generate speech-matched facial expressions and seamless torso regions. Our approach maintains consistency and continuity in visual details across frames and significantly improves rendering speed and quality, achieving up to 101 frames per second. Extensive experiments and user studies demonstrate that SyncTalk++ outperforms state-of-the-art methods in synchronization and realism. We recommend watching the supplementary video: https://ziqiaopeng.github.io/synctalk++.

The angular synchronization problem aims to accurately estimate (up to a constant additive phase) a set of unknown angles theta_1, dots, theta_nin[0, 2pi) from m noisy measurements of their offsets theta_i-theta_j ;mod ; 2pi. Applications include, for example, sensor network localization, phase retrieval, and distributed clock synchronization. An extension of the problem to the heterogeneous setting (dubbed k-synchronization) is to estimate k groups of angles simultaneously, given noisy observations (with unknown group assignment) from each group. Existing methods for angular synchronization usually perform poorly in high-noise regimes, which are common in applications. In this paper, we leverage neural networks for the angular synchronization problem, and its heterogeneous extension, by proposing GNNSync, a theoretically-grounded end-to-end trainable framework using directed graph neural networks. In addition, new loss functions are devised to encode synchronization objectives. Experimental results on extensive data sets demonstrate that GNNSync attains competitive, and often superior, performance against a comprehensive set of baselines for the angular synchronization problem and its extension, validating the robustness of GNNSync even at high noise levels.

Four-dimensional computed tomography (4D CT) reconstruction is crucial for capturing dynamic anatomical changes but faces inherent limitations from conventional phase-binning workflows. Current methods discretize temporal resolution into fixed phases with respiratory gating devices, introducing motion misalignment and restricting clinical practicality. In this paper, We propose X^2-Gaussian, a novel framework that enables continuous-time 4D-CT reconstruction by integrating dynamic radiative Gaussian splatting with self-supervised respiratory motion learning. Our approach models anatomical dynamics through a spatiotemporal encoder-decoder architecture that predicts time-varying Gaussian deformations, eliminating phase discretization. To remove dependency on external gating devices, we introduce a physiology-driven periodic consistency loss that learns patient-specific breathing cycles directly from projections via differentiable optimization. Extensive experiments demonstrate state-of-the-art performance, achieving a 9.93 dB PSNR gain over traditional methods and 2.25 dB improvement against prior Gaussian splatting techniques. By unifying continuous motion modeling with hardware-free period learning, X^2-Gaussian advances high-fidelity 4D CT reconstruction for dynamic clinical imaging. Code is publicly available at: https://x2-gaussian.github.io/.

Co-speech gesture generation is a critical area of research aimed at synthesizing speech-synchronized human-like gestures. Existing methods often suffer from issues such as rhythmic inconsistency, motion jitter, foot sliding and limited multi-sampling diversity. In this paper, we present SmoothSync, a novel framework that leverages quantized audio tokens in a novel dual-stream Diffusion Transformer (DiT) architecture to synthesis holistic gestures and enhance sampling variation. Specifically, we (1) fuse audio-motion features via complementary transformer streams to achieve superior synchronization, (2) introduce a jitter-suppression loss to improve temporal smoothness, (3) implement probabilistic audio quantization to generate distinct gesture sequences from identical inputs. To reliably evaluate beat synchronization under jitter, we introduce Smooth-BC, a robust variant of the beat consistency metric less sensitive to motion noise. Comprehensive experiments on the BEAT2 and SHOW datasets demonstrate SmoothSync's superiority, outperforming state-of-the-art methods by -30.6% FGD, 10.3% Smooth-BC, and 8.4% Diversity on BEAT2, while reducing jitter and foot sliding by -62.9% and -17.1% respectively. The code will be released to facilitate future research.

Modern neural recording techniques allow neuroscientists to obtain spiking activity of multiple neurons from different brain regions over long time periods, which requires new statistical methods to be developed for understanding structure of the large-scale data. In this paper, we develop a bi-clustering method to cluster the neural spiking activity spatially and temporally, according to their low-dimensional latent structures. The spatial (neuron) clusters are defined by the latent trajectories within each neural population, while the temporal (state) clusters are defined by (populationally) synchronous local linear dynamics shared with different periods. To flexibly extract the bi-clustering structure, we build the model non-parametrically, and develop an efficient Markov chain Monte Carlo (MCMC) algorithm to sample the posterior distributions of model parameters. Validating our proposed MCMC algorithm through simulations, we find the method can recover unknown parameters and true bi-clustering structures successfully. We then apply the proposed bi-clustering method to multi-regional neural recordings under different experiment settings, where we find that simultaneously considering latent trajectories and spatial-temporal clustering structures can provide us with a more accurate and interpretable result. Overall, the proposed method provides scientific insights for large-scale (counting) time series with elongated recording periods, and it can potentially have application beyond neuroscience.

We propose the Kuramoto Graph Neural Network (KuramotoGNN), a novel class of continuous-depth graph neural networks (GNNs) that employs the Kuramoto model to mitigate the over-smoothing phenomenon, in which node features in GNNs become indistinguishable as the number of layers increases. The Kuramoto model captures the synchronization behavior of non-linear coupled oscillators. Under the view of coupled oscillators, we first show the connection between Kuramoto model and basic GNN and then over-smoothing phenomenon in GNNs can be interpreted as phase synchronization in Kuramoto model. The KuramotoGNN replaces this phase synchronization with frequency synchronization to prevent the node features from converging into each other while allowing the system to reach a stable synchronized state. We experimentally verify the advantages of the KuramotoGNN over the baseline GNNs and existing methods in reducing over-smoothing on various graph deep learning benchmark tasks.

Alarm fatigue in intensive care units (ICUs) is a well documented patient safety crisis. Clinical monitors generate 350 or more alarms per patient per day, out of which 72-99% are clinically irrelevant. Staff desensitization to non-actionable alarms increases the risk of missed true emergencies. This paper presents SigmaMedStat, a machine learning system that evaluates the trustworthiness of physiological alarm signals before clinical action is taken. Four approaches were evaluated on the PhysioNet/Computing in Cardiology Challenge 2015 dataset of 498 four-channel ICU alarm recordings. Primary contribution is a temporal modeling framework that splits each 60 second recording into six consecutive 10-second chunks, and this in turn generates Continuous Wavelet Transform (CWT) scalograms per chunk, encodes each chunk with a shared EfficientNet-B0 encoder, and passes the resulting feature sequence to a two-layer Long Short-Term Memory (LSTM) network. Five-fold stratified cross-validation yields a mean AUC of 0.822 +/- 0.016 (95% CI: [0.790,0.853]), compared to 0.641 for a static EfficientNet baseline trained on the full 60-second window. Ablation studies confirm that temporal chunking and multi-channel signal fusion both contribute independently to classification performance. Per-alarm type analysis reveals that Ventricular Flutter is the most accurately classified alarm type (AUC 0.820) while Asystole remains the hardest (AUC 0.722). Error analysis identifies 65 false negatives and 85 high-confidence misclassifications as the primary failure modes. All code and results are publicly available at https://github.com/Arun-K-Ram/sigmamedstat.

Most lip-to-speech (LTS) synthesis models are trained and evaluated under the assumption that the audio-video pairs in the dataset are perfectly synchronized. In this work, we show that the commonly used audio-visual datasets, such as GRID, TCD-TIMIT, and Lip2Wav, can have data asynchrony issues. Training lip-to-speech with such datasets may further cause the model asynchrony issue -- that is, the generated speech and the input video are out of sync. To address these asynchrony issues, we propose a synchronized lip-to-speech (SLTS) model with an automatic synchronization mechanism (ASM) to correct data asynchrony and penalize model asynchrony. We further demonstrate the limitation of the commonly adopted evaluation metrics for LTS with asynchronous test data and introduce an audio alignment frontend before the metrics sensitive to time alignment for better evaluation. We compare our method with state-of-the-art approaches on conventional and time-aligned metrics to show the benefits of synchronization training.

In this paper, we present a novel diffusion model called that generates multiview-consistent images from a single-view image. Using pretrained large-scale 2D diffusion models, recent work Zero123 demonstrates the ability to generate plausible novel views from a single-view image of an object. However, maintaining consistency in geometry and colors for the generated images remains a challenge. To address this issue, we propose a synchronized multiview diffusion model that models the joint probability distribution of multiview images, enabling the generation of multiview-consistent images in a single reverse process. SyncDreamer synchronizes the intermediate states of all the generated images at every step of the reverse process through a 3D-aware feature attention mechanism that correlates the corresponding features across different views. Experiments show that SyncDreamer generates images with high consistency across different views, thus making it well-suited for various 3D generation tasks such as novel-view-synthesis, text-to-3D, and image-to-3D.

Remote photoplethysmography (rPPG) is a method for non-contact measurement of physiological signals from facial videos, holding great potential in various applications such as healthcare, affective computing, and anti-spoofing. Existing deep learning methods struggle to address two core issues of rPPG simultaneously: understanding the periodic pattern of rPPG among long contexts and addressing large spatiotemporal redundancy in video segments. These represent a trade-off between computational complexity and the ability to capture long-range dependencies. In this paper, we introduce RhythmMamba, a state space model-based method that captures long-range dependencies while maintaining linear complexity. By viewing rPPG as a time series task through the proposed frame stem, the periodic variations in pulse waves are modeled as state transitions. Additionally, we design multi-temporal constraint and frequency domain feed-forward, both aligned with the characteristics of rPPG time series, to improve the learning capacity of Mamba for rPPG signals. Extensive experiments show that RhythmMamba achieves state-of-the-art performance with 319% throughput and 23% peak GPU memory. The codes are available at https://github.com/zizheng-guo/RhythmMamba.

Sleep is an essential component of human physiology, contributing significantly to overall health and quality of life. Accurate sleep staging and disorder detection are crucial for assessing sleep quality. Studies in the literature have proposed PSG-based approaches and machine-learning methods utilizing single-modality signals. However, existing methods often lack multimodal, multilabel frameworks and address sleep stages and disorders classification separately. In this paper, we propose a 1D-Vision Transformer for simultaneous classification of sleep stages and sleep disorders. Our method exploits the sleep disorders' correlation with specific sleep stage patterns and performs a simultaneous identification of a sleep stage and sleep disorder. The model is trained and tested using multimodal-multilabel sensory data (including photoplethysmogram, respiratory flow, and respiratory effort signals). The proposed method shows an overall accuracy (cohen's Kappa) of 78% (0.66) for five-stage sleep classification and 74% (0.58) for sleep apnea classification. Moreover, we analyzed the encoder attention weights to clarify our models' predictions and investigate the influence different features have on the models' outputs. The result shows that identified patterns, such as respiratory troughs and peaks, make a higher contribution to the final classification process.

During the radiotherapy treatment of patients with lung cancer, the radiation delivered to healthy tissue around the tumor needs to be minimized, which is difficult because of respiratory motion and the latency of linear accelerator systems. In the proposed study, we first use the Lucas-Kanade pyramidal optical flow algorithm to perform deformable image registration of chest computed tomography scan images of four patients with lung cancer. We then track three internal points close to the lung tumor based on the previously computed deformation field and predict their position with a recurrent neural network (RNN) trained using real-time recurrent learning (RTRL) and gradient clipping. The breathing data is quite regular, sampled at approximately 2.5Hz, and includes artificial drift in the spine direction. The amplitude of the motion of the tracked points ranged from 12.0mm to 22.7mm. Finally, we propose a simple method for recovering and predicting 3D tumor images from the tracked points and the initial tumor image based on a linear correspondence model and Nadaraya-Watson non-linear regression. The root-mean-square error, maximum error, and jitter corresponding to the RNN prediction on the test set were smaller than the same performance measures obtained with linear prediction and least mean squares (LMS). In particular, the maximum prediction error associated with the RNN, equal to 1.51mm, is respectively 16.1% and 5.0% lower than the maximum error associated with linear prediction and LMS. The average prediction time per time step with RTRL is equal to 119ms, which is less than the 400ms marker position sampling time. The tumor position in the predicted images appears visually correct, which is confirmed by the high mean cross-correlation between the original and predicted images, equal to 0.955.

Achieving high synchronization in the synthesis of realistic, speech-driven talking head videos presents a significant challenge. Traditional Generative Adversarial Networks (GAN) struggle to maintain consistent facial identity, while Neural Radiance Fields (NeRF) methods, although they can address this issue, often produce mismatched lip movements, inadequate facial expressions, and unstable head poses. A lifelike talking head requires synchronized coordination of subject identity, lip movements, facial expressions, and head poses. The absence of these synchronizations is a fundamental flaw, leading to unrealistic and artificial outcomes. To address the critical issue of synchronization, identified as the "devil" in creating realistic talking heads, we introduce SyncTalk. This NeRF-based method effectively maintains subject identity, enhancing synchronization and realism in talking head synthesis. SyncTalk employs a Face-Sync Controller to align lip movements with speech and innovatively uses a 3D facial blendshape model to capture accurate facial expressions. Our Head-Sync Stabilizer optimizes head poses, achieving more natural head movements. The Portrait-Sync Generator restores hair details and blends the generated head with the torso for a seamless visual experience. Extensive experiments and user studies demonstrate that SyncTalk outperforms state-of-the-art methods in synchronization and realism. We recommend watching the supplementary video: https://ziqiaopeng.github.io/synctalk

In autonomous driving, multi-modal perception tasks like 3D object detection typically rely on well-synchronized sensors, both at training and inference. However, despite the use of hardware- or software-based synchronization algorithms, perfect synchrony is rarely guaranteed: Sensors may operate at different frequencies, and real-world factors such as network latency, hardware failures, or processing bottlenecks often introduce time offsets between sensors. Such asynchrony degrades perception performance, especially for dynamic objects. To address this challenge, we propose AsyncBEV, a trainable lightweight and generic module to improve the robustness of 3D Birds' Eye View (BEV) object detection models against sensor asynchrony. Inspired by scene flow estimation, AsyncBEV first estimates the 2D flow from the BEV features of two different sensor modalities, taking into account the known time offset between these sensor measurements. The predicted feature flow is then used to warp and spatially align the feature maps, which we show can easily be integrated into different current BEV detector architectures (e.g., BEV grid-based and token-based). Extensive experiments demonstrate AsyncBEV improves robustness against both small and large asynchrony between LiDAR or camera sensors in both the token-based CMT and grid-based UniBEV, especially for dynamic objects. We significantly outperform the ego motion compensated CMT and UniBEV baselines, notably by 16.6 % and 11.9 % NDS on dynamic objects in the worst-case scenario of a 0.5 s time offset. Code will be released upon acceptance.

Time series clustering promises to uncover hidden structural patterns in data with applications across healthcare, finance, industrial systems, and other critical domains. However, without validated ground truth information, researchers cannot objectively assess clustering quality or determine whether poor results stem from absent structures in the data, algorithmic limitations, or inappropriate validation methods, raising the question whether clustering is "more art than science" (Guyon et al., 2009). To address these challenges, we introduce CSTS (Correlation Structures in Time Series), a synthetic benchmark for evaluating the discovery of correlation structures in multivariate time series data. CSTS provides a clean benchmark that enables researchers to isolate and identify specific causes of clustering failures by differentiating between correlation structure deterioration and limitations of clustering algorithms and validation methods. Our contributions are: (1) a comprehensive benchmark for correlation structure discovery with distinct correlation structures, systematically varied data conditions, established performance thresholds, and recommended evaluation protocols; (2) empirical validation of correlation structure preservation showing moderate distortion from downsampling and minimal effects from distribution shifts and sparsification; and (3) an extensible data generation framework enabling structure-first clustering evaluation. A case study demonstrates CSTS's practical utility by identifying an algorithm's previously undocumented sensitivity to non-normal distributions, illustrating how the benchmark enables precise diagnosis of methodological limitations. CSTS advances rigorous evaluation standards for correlation-based time series clustering.

Physiological time series signals reflect complex, multi-scale dynamical processes of the human body. Existing modeling studies focus on static tasks such as classification, event forecasting, or short-horizon next step prediction, while long-horizon signal-level forecasting and predictive nature of physiological signals remain underexplored. We introduce NormWear-2, a world model that encodes both multivariate physiological signals and clinical intervention variables into a shared latent space and models their joint temporal evolution as a dynamical system. Our approach combines inference from prior pre-trained knowledge (intuition) with instant non-parametric latent state transition adaptation (insight), enabling coherent forecasting across multiple temporal scales, conditioned on heterogeneous clinical interventions. During the pretraining phase, we find that chaos-theoretic balancing of dynamical regime diversity yields more robust representations, with a smaller balanced corpus outperforming one twice its size and capturing bifurcation regimes. We evaluate the world model performance across diverse real-world physiological datasets spanning heterogeneous temporal resolutions and intervention regimes, covering daily life, point-of-care, and clinical settings, including fitness planning, hemodialysis, diabetes management, and surgical monitoring. These evaluation datasets comprise records from 8,026 subjects, spanning study durations from 3.2 hours for high-resolution signal data to 2.3 years for longitudinal clinical biomarker tracking. NormWear-2 achieves the best overall forecasting performance across time, frequency, and latent representation domains, with significant improvements over state-of-the-art time series foundation models, while maintaining competitive downstream representation quality, providing a step toward general-purpose world models for physiological signals.

The integration of event and tracking data has become essential for advanced analysis in soccer. However, synchronizing these two modalities remains a significant challenge due to temporal and spatial inaccuracies in manually recorded event timestamps. Existing synchronizers typically rely on annotated event locations, which themselves are prone to spatial errors and thus can distort synchronization results. To address this issue, we propose ELASTIC (Event-Location-AgnoSTIC synchronizer), a synchronization framework that only uses features derived from tracking data. ELASTIC also explicitly detects the end times of pass-like events and separates the detection of major and minor events, which improves the completeness of the synchronized output and reduces error cascade across events. We annotated the ground truth timestamps of 2,134 events from three Eredivisie matches to measure the synchronization accuracy, and the experimental results demonstrate that ELASTIC outperforms existing synchronizers by a large margin.

Learning and decision making in the brain are key processes critical to survival, and yet are processes implemented by non-ideal biological building blocks which can impose significant error. We explore quantitatively how the brain might cope with this inherent source of error by taking advantage of two ubiquitous mechanisms, redundancy and synchronization. In particular we consider a neural process whose goal is to learn a decision function by implementing a nonlinear gradient dynamics. The dynamics, however, are assumed to be corrupted by perturbations modeling the error which might be incurred due to limitations of the biology, intrinsic neuronal noise, and imperfect measurements. We show that error, and the associated uncertainty surrounding a learned solution, can be controlled in large part by trading off synchronization strength among multiple redundant neural systems against the noise amplitude. The impact of the coupling between such redundant systems is quantified by the spectrum of the network Laplacian, and we discuss the role of network topology in synchronization and in reducing the effect of noise. A range of situations in which the mechanisms we model arise in brain science are discussed, and we draw attention to experimental evidence suggesting that cortical circuits capable of implementing the computations of interest here can be found on several scales. Finally, simulations comparing theoretical bounds to the relevant empirical quantities show that the theoretical estimates we derive can be tight.

Study Objectives: We investigate a Mamba-based deep learning approach for sleep staging on signals from ANNE One (Sibel Health, Evanston, IL), a non-intrusive dual-module wireless wearable system measuring chest electrocardiography (ECG), triaxial accelerometry, and chest temperature, and finger photoplethysmography and finger temperature. Methods: We obtained wearable sensor recordings from 357 adults undergoing concurrent polysomnography (PSG) at a tertiary care sleep lab. Each PSG recording was manually scored and these annotations served as ground truth labels for training and evaluation of our models. PSG and wearable sensor data were automatically aligned using their ECG channels with manual confirmation by visual inspection. We trained a Mamba-based recurrent neural network architecture on these recordings. Ensembling of model variants with similar architectures was performed. Results: After ensembling, the model attains a 3-class (wake, non rapid eye movement [NREM] sleep, rapid eye movement [REM] sleep) balanced accuracy of 84.02%, F1 score of 84.23%, Cohen's κ of 72.89%, and a Matthews correlation coefficient (MCC) score of 73.00%; a 4-class (wake, light NREM [N1/N2], deep NREM [N3], REM) balanced accuracy of 75.30%, F1 score of 74.10%, Cohen's κ of 61.51%, and MCC score of 61.95%; a 5-class (wake, N1, N2, N3, REM) balanced accuracy of 65.11%, F1 score of 66.15%, Cohen's κ of 53.23%, MCC score of 54.38%. Conclusions: Our Mamba-based deep learning model can successfully infer major sleep stages from the ANNE One, a wearable system without electroencephalography (EEG), and can be applied to data from adults attending a tertiary care sleep clinic.

Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning framework for automatic lung-disease detection using respiratory audio signals. The proposed system integrates two complementary representations: a spectral-temporal encoder based on a CNN-BiLSTM Attention architecture, and a handcrafted acoustic-feature encoder capturing physiologically meaningful descriptors such as MFCCs, spectral centroid, spectral bandwidth, and zero-crossing rate. These branches are combined through late-stage fusion to leverage both data-driven learning and domain-informed acoustic cues. The model is trained and evaluated on the Asthma Detection Dataset Version 2 using rigorous preprocessing, including resampling, normalization, noise filtering, data augmentation, and patient-level stratified partitioning. The study achieved strong generalization with 91.21% accuracy, 0.899 macro F1-score, and 0.9866 macro ROC-AUC, outperforming all ablated variants. An ablation study confirms the importance of temporal modeling, attention mechanisms, and multimodal fusion. The framework incorporates Grad-CAM, Integrated Gradients, and SHAP, generating interpretable spectral, temporal, and feature-level explanations aligned with known acoustic biomarkers to build clinical transparency. The findings demonstrate the framework's potential for telemedicine, point-of-care diagnostics, and real-world respiratory screening.

Diffusion-based generative models have achieved remarkable success in various domains. It trains a shared model on denoising tasks that encompass different noise levels simultaneously, representing a form of multi-task learning (MTL). However, analyzing and improving diffusion models from an MTL perspective remains under-explored. In particular, MTL can sometimes lead to the well-known phenomenon of negative transfer, which results in the performance degradation of certain tasks due to conflicts between tasks. In this paper, we first aim to analyze diffusion training from an MTL standpoint, presenting two key observations: (O1) the task affinity between denoising tasks diminishes as the gap between noise levels widens, and (O2) negative transfer can arise even in diffusion training. Building upon these observations, we aim to enhance diffusion training by mitigating negative transfer. To achieve this, we propose leveraging existing MTL methods, but the presence of a huge number of denoising tasks makes this computationally expensive to calculate the necessary per-task loss or gradient. To address this challenge, we propose clustering the denoising tasks into small task clusters and applying MTL methods to them. Specifically, based on (O2), we employ interval clustering to enforce temporal proximity among denoising tasks within clusters. We show that interval clustering can be solved using dynamic programming, utilizing signal-to-noise ratio, timestep, and task affinity for clustering objectives. Through this, our approach addresses the issue of negative transfer in diffusion models by allowing for efficient computation of MTL methods. We validate the proposed clustering and its integration with MTL methods through various experiments, demonstrating improved sample quality of diffusion models. Our project page is available at https://gohyojun15.github.io/ANT_diffusion/{url}.

Training deep neural networks (DNNs) using traditional backpropagation (BP) presents challenges in terms of computational complexity and energy consumption, particularly for on-device learning where computational resources are limited. Various alternatives to BP, including random feedback alignment, forward-forward, and local classifiers, have been explored to address these challenges. These methods have their advantages, but they can encounter difficulties when dealing with intricate visual tasks or demand considerable computational resources. In this paper, we propose a novel Local Learning rule inspired by neural activity Synchronization phenomena (LLS) observed in the brain. LLS utilizes fixed periodic basis vectors to synchronize neuron activity within each layer, enabling efficient training without the need for additional trainable parameters. We demonstrate the effectiveness of LLS and its variations, LLS-M and LLS-MxM, on multiple image classification datasets, achieving accuracy comparable to BP with reduced computational complexity and minimal additional parameters. Furthermore, the performance of LLS on the Visual Wake Word (VWW) dataset highlights its suitability for on-device learning tasks, making it a promising candidate for edge hardware implementations.

Training of large language models (LLMs) is typically distributed across a large number of accelerators to reduce training time. Since internal states and parameter gradients need to be exchanged at each and every single gradient step, all devices need to be co-located using low-latency high-bandwidth communication links to support the required high volume of exchanged bits. Recently, distributed algorithms like DiLoCo have relaxed such co-location constraint: accelerators can be grouped into ``workers'', where synchronizations between workers only occur infrequently. This in turn means that workers can afford being connected by lower bandwidth communication links without affecting learning quality. However, in these methods, communication across workers still requires the same peak bandwidth as before, as the synchronizations require all parameters to be exchanged across all workers. In this paper, we improve DiLoCo in three ways. First, we synchronize only subsets of parameters in sequence, rather than all at once, which greatly reduces peak bandwidth. Second, we allow workers to continue training while synchronizing, which decreases wall clock time. Third, we quantize the data exchanged by workers, which further reduces bandwidth across workers. By properly combining these modifications, we show experimentally that we can distribute training of billion-scale parameters and reach similar quality as before, but reducing required bandwidth by two orders of magnitude.

Visible-light cameras can capture subtle physiological biomarkers without physical contact with the subject. We present the Multi-Site Physiological Monitoring (MSPM) dataset, which is the first dataset collected to support the study of simultaneous camera-based vital signs estimation from multiple locations on the body. MSPM enables research on remote photoplethysmography (rPPG), respiration rate, and pulse transit time (PTT); it contains ground-truth measurements of pulse oximetry (at multiple body locations) and blood pressure using contacting sensors. We provide thorough experiments demonstrating the suitability of MSPM to support research on rPPG, respiration rate, and PTT. Cross-dataset rPPG experiments reveal that MSPM is a challenging yet high quality dataset, with intra-dataset pulse rate mean absolute error (MAE) below 4 beats per minute (BPM), and cross-dataset pulse rate MAE below 2 BPM in certain cases. Respiration experiments find a MAE of 1.09 breaths per minute by extracting motion features from the chest. PTT experiments find that across the pairs of different body sites, there is high correlation between remote PTT and contact-measured PTT, which facilitates the possibility for future camera-based PTT research.

Text-based 2D diffusion models have demonstrated impressive capabilities in image generation and editing. Meanwhile, the 2D diffusion models also exhibit substantial potentials for 3D editing tasks. However, how to achieve consistent edits across multiple viewpoints remains a challenge. While the iterative dataset update method is capable of achieving global consistency, it suffers from slow convergence and over-smoothed textures. We propose SyncNoise, a novel geometry-guided multi-view consistent noise editing approach for high-fidelity 3D scene editing. SyncNoise synchronously edits multiple views with 2D diffusion models while enforcing multi-view noise predictions to be geometrically consistent, which ensures global consistency in both semantic structure and low-frequency appearance. To further enhance local consistency in high-frequency details, we set a group of anchor views and propagate them to their neighboring frames through cross-view reprojection. To improve the reliability of multi-view correspondences, we introduce depth supervision during training to enhance the reconstruction of precise geometries. Our method achieves high-quality 3D editing results respecting the textual instructions, especially in scenes with complex textures, by enhancing geometric consistency at the noise and pixel levels.

During lung radiotherapy, the position of infrared reflective objects on the chest can be recorded to estimate the tumor location. However, radiotherapy systems have a latency inherent to robot control limitations that impedes the radiation delivery precision. Prediction with online learning of recurrent neural networks (RNN) allows for adaptation to non-stationary respiratory signals, but classical methods such as RTRL and truncated BPTT are respectively slow and biased. This study investigates the capabilities of unbiased online recurrent optimization (UORO) to forecast respiratory motion and enhance safety in lung radiotherapy. We used 9 observation records of the 3D position of 3 external markers on the chest and abdomen of healthy individuals breathing during intervals from 73s to 222s. The sampling frequency was 10Hz, and the amplitudes of the recorded trajectories range from 6mm to 40mm in the superior-inferior direction. We forecast the 3D location of each marker simultaneously with a horizon value between 0.1s and 2.0s, using an RNN trained with UORO. We compare its performance with an RNN trained with RTRL, LMS, and offline linear regression. We provide closed-form expressions for quantities involved in the loss gradient calculation in UORO, thereby making its implementation efficient. Training and cross-validation were performed during the first minute of each sequence. On average over the horizon values considered and the 9 sequences, UORO achieves the lowest root-mean-square (RMS) error and maximum error among the compared algorithms. These errors are respectively equal to 1.3mm and 8.8mm, and the prediction time per time step was lower than 2.8ms (Dell Intel core i9-9900K 3.60 GHz). Linear regression has the lowest RMS error for the horizon values 0.1s and 0.2s, followed by LMS for horizon values between 0.3s and 0.5s, and UORO for horizon values greater than 0.6s.

While recent advancements in text-to-video diffusion models enable high-quality short video generation from a single prompt, generating real-world long videos in a single pass remains challenging due to limited data and high computational costs. To address this, several works propose tuning-free approaches, i.e., extending existing models for long video generation, specifically using multiple prompts to allow for dynamic and controlled content changes. However, these methods primarily focus on ensuring smooth transitions between adjacent frames, often leading to content drift and a gradual loss of semantic coherence over longer sequences. To tackle such an issue, we propose Synchronized Coupled Sampling (SynCoS), a novel inference framework that synchronizes denoising paths across the entire video, ensuring long-range consistency across both adjacent and distant frames. Our approach combines two complementary sampling strategies: reverse and optimization-based sampling, which ensure seamless local transitions and enforce global coherence, respectively. However, directly alternating between these samplings misaligns denoising trajectories, disrupting prompt guidance and introducing unintended content changes as they operate independently. To resolve this, SynCoS synchronizes them through a grounded timestep and a fixed baseline noise, ensuring fully coupled sampling with aligned denoising paths. Extensive experiments show that SynCoS significantly improves multi-event long video generation, achieving smoother transitions and superior long-range coherence, outperforming previous approaches both quantitatively and qualitatively.

We develop a dynamical mean-field theory for random recurrent networks with low-rank structure and firing-rate-driven adaptation. When the random connectivity is strong enough to generate chaos, increasing adaptation strength drives the network through four regimes: a static coherent state, noise-sustained oscillations that progress from regular to irregular, stochastic switching between symmetric wells, and a global limit cycle. The theory identifies two instability mechanisms, chaos onset from the random connectivity and a Hopf bifurcation of the coherent mode, and shows how adaptation shapes both through the frequency-dependent single-neuron transfer function. A reduced three-dimensional model captures the bifurcation structure of the full network. Above the chaos threshold, coherent population-level oscillations coexist with heterogeneous firing rates and network-generated stochasticity at the single-neuron level. The interaction of adaptation with random and low-rank connectivity produces a rich oscillatory repertoire, including waxing-and-waning rhythmic episodes, persistent state switching, and slow Up-Down alternations, dynamics that have been observed during wakefulness, sleep, and anesthesia.

Accurate classification of sleep stages from less obtrusive sensor measurements such as the electrocardiogram (ECG) or photoplethysmogram (PPG) could enable important applications in sleep medicine. Existing approaches to this problem have typically used deep learning models designed and trained to operate on one or more specific input signals. However, the datasets used to develop these models often do not contain the same sets of input signals. Some signals, particularly PPG, are much less prevalent than others, and this has previously been addressed with techniques such as transfer learning. Additionally, only training on one or more fixed modalities precludes cross-modal information transfer from other sources, which has proved valuable in other problem domains. To address this, we introduce wav2sleep, a unified model designed to operate on variable sets of input signals during training and inference. After jointly training on over 10,000 overnight recordings from six publicly available polysomnography datasets, including SHHS and MESA, wav2sleep outperforms existing sleep stage classification models across test-time input combinations including ECG, PPG, and respiratory signals.

Training large language models is generally done via optimization methods on clusters containing tens of thousands of accelerators, communicating over a high-bandwidth interconnect. Scaling up these clusters is expensive and can become impractical, imposing limits on the size of models that can be trained. Several recent studies have proposed training methods that are less communication intensive, avoiding the need for a highly connected compute cluster. These state-of-the-art low communication training methods still employ a synchronization step for model parameters, which, when performed over all model replicas, can become costly on a low-bandwidth network. In this work, we propose a novel optimization method, NoLoCo, that does not explicitly synchronize all model parameters during training and, as a result, does not require any collective communication. NoLoCo implicitly synchronizes model weights via a novel variant of the Nesterov momentum optimizer by partially averaging model weights with a randomly selected other one. We provide both a theoretical convergence analysis for our proposed optimizer as well as empirical results from language model training. We benchmark NoLoCo on a wide range of accelerator counts and model sizes, between 125M to 6.8B parameters. Our method requires significantly less communication overhead than fully sharded data parallel training or even widely used low communication training method, DiLoCo. The synchronization step itself is estimated to be one magnitude faster than the all-reduce used in DiLoCo for few hundred accelerators training over the internet. We also do not have any global blocking communication that reduces accelerator idling time. Compared to DiLoCo, we also observe up to 4% faster convergence rate with wide range of model sizes and accelerator counts.

Sleep abnormalities can have severe health consequences. Automated sleep staging, i.e. labelling the sequence of sleep stages from the patient's physiological recordings, could simplify the diagnostic process. Previous work on automated sleep staging has achieved great results, mainly relying on the EEG signal. However, often multiple sources of information are available beyond EEG. This can be particularly beneficial when the EEG recordings are noisy or even missing completely. In this paper, we propose CoRe-Sleep, a Coordinated Representation multimodal fusion network that is particularly focused on improving the robustness of signal analysis on imperfect data. We demonstrate how appropriately handling multimodal information can be the key to achieving such robustness. CoRe-Sleep tolerates noisy or missing modalities segments, allowing training on incomplete data. Additionally, it shows state-of-the-art performance when testing on both multimodal and unimodal data using a single model on SHHS-1, the largest publicly available study that includes sleep stage labels. The results indicate that training the model on multimodal data does positively influence performance when tested on unimodal data. This work aims at bridging the gap between automated analysis tools and their clinical utility.

Clustering aims to group unlabelled samples based on their similarities. It has become a significant tool for the analysis of high-dimensional data. However, most of the clustering methods merely generate pseudo labels and thus are unable to simultaneously present the similarities between different clusters and outliers. This paper proposes a new framework called High-dimensional Clustering onto Hamiltonian Cycle (HCHC) to solve the above problems. First, HCHC combines global structure with local structure in one objective function for deep clustering, improving the labels as relative probabilities, to mine the similarities between different clusters while keeping the local structure in each cluster. Then, the anchors of different clusters are sorted on the optimal Hamiltonian cycle generated by the cluster similarities and mapped on the circumference of a circle. Finally, a sample with a higher probability of a cluster will be mapped closer to the corresponding anchor. In this way, our framework allows us to appreciate three aspects visually and simultaneously - clusters (formed by samples with high probabilities), cluster similarities (represented as circular distances), and outliers (recognized as dots far away from all clusters). The experiments illustrate the superiority of HCHC.

In lung radiotherapy, infrared cameras can track reflective objects on the chest to estimate tumor motion due to breathing, but treatment system latencies hinder radiation beam precision. Real-time recurrent learning (RTRL) is a potential solution that can learn patterns within non-stationary respiratory data but has high complexity. This study assesses the capabilities of resource-efficient online RNN algorithms, namely unbiased online recurrent optimization (UORO), sparse-1 step approximation (SnAp-1), and decoupled neural interfaces (DNI) to forecast respiratory motion during radiotherapy treatment accurately. We use time series containing the 3D positions of external markers on the chest of healthy subjects. We propose efficient implementations for SnAp-1 and DNI that compress the influence and immediate Jacobian matrices and accurately update the linear coefficients used in credit assignment estimation, respectively. Data was originally sampled at 10Hz; we resampled it at 3.33Hz and 30Hz to analyze the effect of the sampling rate on performance. We use UORO, SnAp-1, and DNI to forecast each marker's 3D position with horizons h<=2.1s (the time interval in advance for which the prediction is made) and compare them with RTRL, least mean squares, kernel support vector regression, and linear regression. RNNs trained online achieved similar or better accuracy than most previous works using larger training databases and deep learning, even though we used only the first minute of each sequence to predict motion within that exact sequence. SnAp-1 had the lowest normalized root mean square errors (nRMSEs) averaged over the horizon values considered, equal to 0.335 and 0.157, at 3.33Hz and 10.0Hz, respectively. Similarly, UORO had the lowest nRMSE at 30Hz, equal to 0.086. DNI's inference time (6.8ms per time step at 30Hz, Intel Core i7-13700 CPU) was the lowest among the RNN methods.

Synthesizing realistic human-object interaction motions is a critical problem in VR/AR and human animation. Unlike the commonly studied scenarios involving a single human or hand interacting with one object, we address a more generic multi-body setting with arbitrary numbers of humans, hands, and objects. This complexity introduces significant challenges in synchronizing motions due to the high correlations and mutual influences among bodies. To address these challenges, we introduce SyncDiff, a novel method for multi-body interaction synthesis using a synchronized motion diffusion strategy. SyncDiff employs a single diffusion model to capture the joint distribution of multi-body motions. To enhance motion fidelity, we propose a frequency-domain motion decomposition scheme. Additionally, we introduce a new set of alignment scores to emphasize the synchronization of different body motions. SyncDiff jointly optimizes both data sample likelihood and alignment likelihood through an explicit synchronization strategy. Extensive experiments across four datasets with various multi-body configurations demonstrate the superiority of SyncDiff over existing state-of-the-art motion synthesis methods.

Lip synchronization is the task of aligning a speaker's lip movements in video with corresponding speech audio, and it is essential for creating realistic, expressive video content. However, existing methods often rely on reference frames and masked-frame inpainting, which limit their robustness to identity consistency, pose variations, facial occlusions, and stylized content. In addition, since audio signals provide weaker conditioning than visual cues, lip shape leakage from the original video will affect lip sync quality. In this paper, we present OmniSync, a universal lip synchronization framework for diverse visual scenarios. Our approach introduces a mask-free training paradigm using Diffusion Transformer models for direct frame editing without explicit masks, enabling unlimited-duration inference while maintaining natural facial dynamics and preserving character identity. During inference, we propose a flow-matching-based progressive noise initialization to ensure pose and identity consistency, while allowing precise mouth-region editing. To address the weak conditioning signal of audio, we develop a Dynamic Spatiotemporal Classifier-Free Guidance (DS-CFG) mechanism that adaptively adjusts guidance strength over time and space. We also establish the AIGC-LipSync Benchmark, the first evaluation suite for lip synchronization in diverse AI-generated videos. Extensive experiments demonstrate that OmniSync significantly outperforms prior methods in both visual quality and lip sync accuracy, achieving superior results in both real-world and AI-generated videos.

In distributed deep learning with data parallelism, synchronizing gradients at each training step can cause a huge communication overhead, especially when many nodes work together to train large models. Local gradient methods, such as Local SGD, address this issue by allowing workers to compute locally for H steps without synchronizing with others, hence reducing communication frequency. While H has been viewed as a hyperparameter to trade optimization efficiency for communication cost, recent research indicates that setting a proper H value can lead to generalization improvement. Yet, selecting a proper H is elusive. This work proposes a theory-grounded method for determining H, named the Quadratic Synchronization Rule (QSR), which recommends dynamically setting H in proportion to 1{eta^2} as the learning rate eta decays over time. Extensive ImageNet experiments on ResNet and ViT show that local gradient methods with QSR consistently improve the test accuracy over other synchronization strategies. Compared with the standard data parallel training, QSR enables Local AdamW on ViT-B to cut the training time on 16 or 64 GPUs down from 26.7 to 20.2 hours or from 8.6 to 5.5 hours and, at the same time, achieves 1.16% or 0.84% higher top-1 validation accuracy.

Foundation models offer a promising route to compress multi-modal physiological signals into compact representations of human health, with broad applications across sleep medicine, cardiology, neurology and other healthcare domains. Existing models have typically been trained with masked-reconstruction or contrastive objectives. However, masked reconstruction may be poorly suited to the stochastic nature of these signals, while contrastive approaches rely on positive-pair definitions despite the semantic invariances of physiological signals being poorly understood. In this work, we show that next-token prediction is a simple and scalable alternative. We develop Hypnos, a multi-modal sleep foundation model trained using eight different sensing modalities (e.g. EEG, ECG, respiratory signals) drawn from over 20,000 overnight polysomnography recordings. We tokenize each modality into streams of discrete tokens using residual vector quantization, then train a large auto-regressive RQ-Transformer to jointly predict the next token across all modalities in parallel. After training, Hypnos can be applied to continuous streams of sensor data from any subset of supported modalities, generating embeddings for downstream tasks. Across a range of benchmarks, Hypnos significantly outperforms existing foundation models. In sleep stage classification, we match the performance of strong supervised baselines on held-out test sets whilst using \(100\times\) less labelled data. Hypnos even generalises to daytime physiology, surpassing a dedicated ECG foundation model at detecting atrial fibrillation. Our results demonstrate that next-token prediction is a strong self-supervised objective for representation learning from multi-modal physiological signals.

Spatiotemporal neural dynamics and oscillatory synchronization are widely implicated in biological information processing and have been hypothesized to support flexible coordination such as feature binding. By contrast, most deep learning architectures represent and propagate information through activation values, neglecting the joint dynamics of rate and phase. In this work, we introduce Kuramoto oscillatory Phase Encoding (KoPE) as an additional, evolving phase state to Vision Transformers, incorporating a neuro-inspired synchronization mechanism to advance learning efficiency. We show that KoPE can improve training, parameter, and data efficiency of vision models through synchronization-enhanced structure learning. Moreover, KoPE benefits tasks requiring structured understanding, including semantic and panoptic segmentation, representation alignment with language, and few-shot abstract visual reasoning (ARC-AGI). Theoretical analysis and empirical verification further suggest that KoPE can accelerate attention concentration for learning efficiency. These results indicate that synchronization can serve as a scalable, neuro-inspired mechanism for advancing state-of-the-art neural network models.

Synchronization in one dimension displays generic scale invariance with universal properties previously observed in surface kinetic roughening and the wider context of the Kardar-Parisi-Zhang (KPZ) universality class. This has been established for phase oscillators and also for some limit-cycle oscillators, both in the presence of columnar (quenched) disorder and of time-dependent noise, by extensive numerical simulations, and has been analytically motivated by continuum approximations in the strong oscillator coupling limit. The robustness and the precise boundaries in parameter space for such critical behavior remain unclear, however, which may preclude further developments, including the extension of these results to higher dimensions and the experimental observation of nonequilibrium criticality in synchronizing (e.g.~electronic or chemical) oscillators. We here present complete numerical phase diagrams of one-dimensional synchronization, including saturation times and values, but, most importantly, also dynamical features giving insight into the gradual emergence of synchronous dynamics, based on systems of phase oscillators with either type of randomness. In the absence of synchronization, the dynamics evolves as expected for random deposition (for time-dependent noise) or linear growth (for columnar disorder), while a crossover from Edwards-Wilkinson to Kardar-Parisi-Zhang behavior (with the corresponding type of randomness) is observed as the randomness strength, or the nonoddity of the coupling among oscillators, is increased in the synchronous region -- their combined effect being partially captured by the so-called KPZ coupling. The distortion of scaling due to phase slips near the desynchronization boundary, a feature that is likely to play a role in experimental contexts, is also discussed.

Respiratory motion complicates accurate irradiation of thoraco-abdominal tumors during radiotherapy, as treatment-system latency entails target-location uncertainties. This work addresses frame forecasting in chest and liver cine MRI to compensate for such delays. We investigate RNNs trained with online learning algorithms, enabling adaptation to changing respiratory patterns via on-the-fly parameter updates, and transformers, increasingly common in time-series forecasting for their ability to capture long-term dependencies. Experiments used 12 sagittal thoracic and upper-abdominal cine-MRI sequences from ETH Zürich and OvGU; the OvGU data exhibited higher motion variability, noise, and lower contrast. PCA decomposes the Lucas-Kanade optical-flow field into static deformation modes and low-dimensional, time-dependent weights. We compare various methods for forecasting these weights: linear filters, population and sequence-specific transformer encoders, and RNNs trained with real-time recurrent learning (RTRL), unbiased online recurrent optimization, decoupled neural interfaces, and sparse one-step approximation (SnAp-1). Predicted displacements were used to warp the reference frame and generate future images. Prediction accuracy decreased with the horizon h. Linear regression performed best at short horizons (1.3mm geometrical error at h=0.32s, ETH Zürich dataset), while RTRL and SnAp-1 outperformed the other algorithms at medium-to-long horizons, with geometrical errors below 1.4mm and 2.8mm on the sequences from ETH Zürich and OvGU, respectively. The sequence-specific transformer was competitive for low-to-medium horizons, but transformers remained overall limited by data scarcity and domain shift between datasets. Predicted frames visually resembled the ground truth, with notable errors occurring near the diaphragm at end-inspiration and regions affected by out-of-plane motion.

Recent advancements in speech-driven 3D talking head generation have made significant progress in lip synchronization. However, existing models still struggle to capture the perceptual alignment between varying speech characteristics and corresponding lip movements. In this work, we claim that three criteria -- Temporal Synchronization, Lip Readability, and Expressiveness -- are crucial for achieving perceptually accurate lip movements. Motivated by our hypothesis that a desirable representation space exists to meet these three criteria, we introduce a speech-mesh synchronized representation that captures intricate correspondences between speech signals and 3D face meshes. We found that our learned representation exhibits desirable characteristics, and we plug it into existing models as a perceptual loss to better align lip movements to the given speech. In addition, we utilize this representation as a perceptual metric and introduce two other physically grounded lip synchronization metrics to assess how well the generated 3D talking heads align with these three criteria. Experiments show that training 3D talking head generation models with our perceptual loss significantly improve all three aspects of perceptually accurate lip synchronization. Codes and datasets are available at https://perceptual-3d-talking-head.github.io/.

A scuba diver holding constant depth balances on an unstable equilibrium: the gas carried in the suit and buoyancy compensator compresses with depth, so the buoyant force falls as the diver sinks and rises as the diver ascends. We represent the diver as a proportional-derivative controller that regulates this compressible-buoyancy saddle after a finite reaction delay, and we derive the governing delay differential equation from the vertical force balance and the isothermal gas law, reducing it to a damping ratio, two control gains, and a dimensionless delay. The characteristic spectrum, obtained by pseudospectral collocation of the semigroup generator and checked against a direct Newton solution of the characteristic equation, locates the Hopf boundary that separates stable hovering from sustained porpoising; for the baseline diver the critical reaction delay is 3.36 s and the onset period is 28.8 s. The bifurcation is supercritical, and because the saturating force is the quadratic hydrodynamic drag, the limit-cycle amplitude grows in proportion to the delay excess rather than as its square root. The safe-operating envelope shows that runaway ascent is triggered by saturation of the compensator, not by loss of linear stability, so a stable and an unstable diver can share the same escape threshold. As onset is approached, the lag-one autocorrelation and variance rise while the fitted recovery rate falls and matches the spectral abscissa, giving an eigenvalue-exact early warning of the transition.

Diffusion-based lip synchronization models achieve strong visual quality and audio-visual alignment, but full-sequence bidirectional attention and many denoising steps make them impractical for real-time inference. We present Lip Forcing, to our knowledge the first autoregressive diffusion method for video-to-video (V2V) lip synchronization, which distills a 14B audio-conditioned bidirectional video diffusion teacher into causal students. At inference, the students generate each chunk in only two denoising steps without inference-time CFG, enabling real-time lip synchronization. A lip-sync-specific teacher-trajectory analysis reveals a CFG fidelity-sync tradeoff: no-CFG predictions favor reference fidelity, whereas CFG-guided predictions favor synchronization within a mid-trajectory band. Lip Forcing translates this finding into three analysis-derived components: Sync-Window DMD, a two-step inference schedule, and a SyncNet-based reward. We validate Lip Forcing at two student scales, both distilled from the 14B teacher. The 1.3B student crosses into real-time streaming at 31 FPS, 17.6times faster than its same-scale bidirectional model. The 14B student, the largest diffusion model reported for V2V lip synchronization, runs 39.8times faster than its teacher at comparable reference fidelity. Time-to-first-frame is sub-millisecond at both scales, far below every diffusion baseline.

Physiological foundation models (FMs) have shown promise for biosignal representation learning, yet most remain confined to a single modality such as EEG, ECG, or PPG, largely because paired multimodal datasets are scarce. In this paper, we present PanLUNA, a compact 5.4M-parameter pan-modal FM that jointly processes EEG, ECG, and PPG within a single shared encoder. Extending LUNA's channel-unification module, PanLUNA treats multimodal channels as entries in a unified query set augmented with sensor-type embeddings, enabling efficient cross-modal early fusion while remaining inherently robust to missing modalities at inference time. Despite its small footprint, PanLUNA matches or exceeds models up to 57times larger: 81.21% balanced accuracy on TUAB abnormal EEG detection and state-of-the-art 0.7416 balanced accuracy on HMC multimodal sleep staging. Quantization-aware training with INT8 weights recovers geq96% of full-precision performance, and deployment on the GAP9 ultra-low-power RISC-V microcontroller for wearables achieves 325.6 ms latency and 18.8 mJ per 10-second, 12-lead ECG inference, and 1.206 s latency at 68.65 mJ for multimodal 5-channel sleep staging over 30-second epochs.

A network of oscillators that synchronizes perfectly computes nothing further, so an attention architecture built from synchronization must locate its computation in structured departures from agreement. We introduce the Frustrated Synchronization Network (FSN), whose token states are phases on a torus and whose entire value pathway is one learned complex coupling kernel over harmonics and a one-step delay. Each component of the kernel is a frustration in the sense of the synchronization literature. The complex phases are static Kuramoto-Sakaguchi frustration angles, the signed harmonics are repulsive Daido components, and the delay term, which couples each token to the successors of the tokens it attends to, is algebraically identical to Kuramoto-Sakaguchi coupling whose frustration angle is the data's own transition, so next-token prediction is implemented as synchronization frustrated by the data. At matched one-million-parameter and training budgets on character-level text and code, the FSN's validation loss is below a tuned RoPE-SwiGLU transformer's at every epoch measured, and the comparison survives training the baseline to convergence: every thirty-epoch enwik8 seed finishes below the transformer's converged fifty-epoch loss of 1.611, and the FSN's completed fifty-epoch runs converge to 1.5953 +/- 0.0014. A variant with every feed-forward block replaced by mean-field coupling to learned collective modes, leaving no multilayer perceptron in the stack, tracks the transformer. On natural text the unfrustrated base layer falls behind the converged transformer at every copy depth, worst on long-range copy events; the kernel reverses the deficit at every depth of four and beyond. Headline comparisons are at the one-million-parameter scale; a scale ladder is complete through four million parameters with the advantage persisting, and remaining arms are marked as in progress.

This paper proposes singing voice synthesis (SVS) based on frame-level sequence-to-sequence models considering vocal timing deviation. In SVS, it is essential to synchronize the timing of singing with temporal structures represented by scores, taking into account that there are differences between actual vocal timing and note start timing. In many SVS systems including our previous work, phoneme-level score features are converted into frame-level ones on the basis of phoneme boundaries obtained by external aligners to take into account vocal timing deviations. Therefore, the sound quality is affected by the aligner accuracy in this system. To alleviate this problem, we introduce an attention mechanism with frame-level features. In the proposed system, the attention mechanism absorbs alignment errors in phoneme boundaries. Additionally, we evaluate the system with pseudo-phoneme-boundaries defined by heuristic rules based on musical scores when there is no aligner. The experimental results show the effectiveness of the proposed system.

The COVID-19 pandemic has underscored the need for low-cost, scalable approaches to measuring contactless vital signs, either during initial triage at a healthcare facility or virtual telemedicine visits. Remote photoplethysmography (rPPG) can accurately estimate heart rate (HR) when applied to close-up videos of healthy volunteers in well-lit laboratory settings. However, results from such highly optimized laboratory studies may not be readily translated to healthcare settings. One significant barrier to the practical application of rPPG in health care is the accurate localization of the region of interest (ROI). Clinical or telemedicine visits may involve sub-optimal lighting, movement artifacts, variable camera angle, and subject distance. This paper presents an rPPG ROI selection method based on 3D facial landmarks and patient head yaw angle. We then demonstrate the robustness of this ROI selection method when coupled to the Plane-Orthogonal-to-Skin (POS) rPPG method when applied to videos of patients presenting to an Emergency Department for respiratory complaints. Our results demonstrate the effectiveness of our proposed approach in improving the accuracy and robustness of rPPG in a challenging clinical environment.

Text-to-video and image-to-video generation have made rapid progress in visual quality, but they remain limited in controlling the precise timing of motion. In contrast, audio provides temporal cues aligned with video motion, making it a promising condition for temporally controlled video generation. However, existing audio-to-video (A2V) models struggle with fine-grained synchronization due to indirect conditioning mechanisms or limited temporal modeling capacity. We present Syncphony, which generates 380x640 resolution, 24fps videos synchronized with diverse audio inputs. Our approach builds upon a pre-trained video backbone and incorporates two key components to improve synchronization: (1) Motion-aware Loss, which emphasizes learning at high-motion regions; (2) Audio Sync Guidance, which guides the full model using a visually aligned off-sync model without audio layers to better exploit audio cues at inference while maintaining visual quality. To evaluate synchronization, we propose CycleSync, a video-to-audio-based metric that measures the amount of motion cues in the generated video to reconstruct the original audio. Experiments on AVSync15 and The Greatest Hits datasets demonstrate that Syncphony outperforms existing methods in both synchronization accuracy and visual quality. Project page is available at: https://jibin86.github.io/syncphony_project_page

Polysomnography (PSG) provides the gold standard for sleep assessment but suffers from substantial heterogeneity across recording devices and cohorts. There have been growing efforts to build general-purpose foundation models (FMs) for sleep physiology, but lack an in-depth understanding of the pre-training process and scaling patterns that lead to more generalizable sleep FMs. To fill this gap, we curate a massive corpus of 166,500 hours of sleep recordings from nine public sources and establish SleepBench, a comprehensive, fully open-source benchmark. Leveraging SleepBench, we systematically evaluate four families of self-supervised pre-training objectives and uncover three critical findings: (1) existing FMs fail to generalize to missing channels at inference; (2) channel-invariant feature learning is essential for pre-training; and (3) scaling sample size, model capacity, and multi-source data mixture consistently improves downstream performance.With an enhanced pre-training and scaling recipe, we introduce OSF, a family of sleep FMs that achieves state-of-the-art performance across nine datasets on diverse sleep and disease prediction tasks. Further analysis of OSF also reveals intriguing properties in sample efficiency, hierarchical aggregation, and cross-dataset scaling.

We put forward the dynamical study of a novel higher-order small network of Chialvo neurons arranged in a ring-star topology, with the neurons interacting via linear diffusive couplings. This model is perceived to imitate the nonlinear dynamical properties exhibited by a realistic nervous system where the neurons transfer information through higher-order multi-body interactions. We first analyze our model using the tools from nonlinear dynamics literature: fixed point analysis, Jacobian matrix, and bifurcation patterns. We observe the coexistence of chaotic attractors, and also an intriguing route to chaos starting from a fixed point, to period-doubling, to cyclic quasiperiodic closed invariant curves, to ultimately chaos. We numerically observe the existence of codimension-1 bifurcation patterns: saddle-node, period-doubling, and Neimark Sacker. We also qualitatively study the typical phase portraits of the system and numerically quantify chaos and complexity using the 0-1 test and sample entropy measure respectively. Finally, we study the collective behavior of the neurons in terms of two synchronization measures: the cross-correlation coefficient, and the Kuramoto order parameter.

Speech emotion recognition (SER) is essential for humanoid robot tasks such as social robotic interactions and robotic psychological diagnosis, where interpretable and efficient models are critical for safety and performance. Existing deep models trained on large datasets remain largely uninterpretable, often insufficiently modeling underlying emotional acoustic signals and failing to capture and analyze the core physiology of emotional vocal behaviors. Physiological research on human voices shows that the dynamics of vocal amplitude and phase correlate with emotions through the vocal tract filter and the glottal source. However, most existing deep models solely involve amplitude but fail to couple the physiological features of and between amplitude and phase. Here, we propose PhysioSER, a physiology-informed vocal spectrotemporal representation learning method, to address these issues with a compact, plug-and-play design. PhysioSER constructs amplitude and phase views informed by voice anatomy and physiology (VAP) to complement SSL models for SER. This VAP-informed framework incorporates two parallel workflows: a vocal feature representation branch to decompose vocal signals based on VAP, embed them into a quaternion field, and use Hamilton-structured quaternion convolutions for modeling their dynamic interactions; and a latent representation branch based on a frozen SSL backbone. Then, utterance-level features from both workflows are aligned by a Contrastive Projection and Alignment framework, followed by a shallow attention fusion head for SER classification. PhysioSER is shown to be interpretable and efficient for SER through extensive evaluations across 14 datasets, 10 languages, and 6 backbones, and its practical efficacy is validated by real-time deployment on a humanoid robotic platform.

Chronic Obstructive Pulmonary Disease (COPD), a major chronic respiratory disease with persistent airflow limitation, is a leading global cause of disability and mortality. Respiratory spirogram time series, routinely collected during pulmonary function tests (PFTs), play a critical role in the early detection of repsiratory diseases and in monitoring lung function over time. However, most current AI models for COPD diagnosis are limited to outputting classification results without providing a rationale for their diagnostic process, while current Large Language Models (LLMs) cannot understand spirograms yet, which severely limits their clinical trust and adoption. To tackle this challenge, we leverage a cohort of 234,028 individuals from the UK Biobank (UKB) to propose SpiroLLM, the first multimodal large language model that can understand spirogram. The model extracts morphological features from respiratory curves via a SpiroEncoder and aligns them with PFT numerical values in a unified latent space using a SpiroProjector, ultimately empowering a large language model to generate a comprehensive diagnostic report. Experimental results confirm that SpiroLLM achieved a diagnostic AUROC of 0.8980 (95% CI: 0.8820-0.9132). In a robustness test with missing core data, it maintained a 100% valid response rate, far surpassing the 13.4% of a text-only model and showcasing the superiority of its multimodal design. This work demonstrates the substantial potential of deeply fusing physiological signals with large language models, establishing a new paradigm for the next generation of interpretable and reliable clinical decision support tools.

Telehealth and remote health monitoring have become increasingly important during the SARS-CoV-2 pandemic and it is widely expected that this will have a lasting impact on healthcare practices. These tools can help reduce the risk of exposing patients and medical staff to infection, make healthcare services more accessible, and allow providers to see more patients. However, objective measurement of vital signs is challenging without direct contact with a patient. We present a video-based and on-device optical cardiopulmonary vital sign measurement approach. It leverages a novel multi-task temporal shift convolutional attention network (MTTS-CAN) and enables real-time cardiovascular and respiratory measurements on mobile platforms. We evaluate our system on an Advanced RISC Machine (ARM) CPU and achieve state-of-the-art accuracy while running at over 150 frames per second which enables real-time applications. Systematic experimentation on large benchmark datasets reveals that our approach leads to substantial (20%-50%) reductions in error and generalizes well across datasets.

The remarkable capabilities of pretrained image diffusion models have been utilized not only for generating fixed-size images but also for creating panoramas. However, naive stitching of multiple images often results in visible seams. Recent techniques have attempted to address this issue by performing joint diffusions in multiple windows and averaging latent features in overlapping regions. However, these approaches, which focus on seamless montage generation, often yield incoherent outputs by blending different scenes within a single image. To overcome this limitation, we propose SyncDiffusion, a plug-and-play module that synchronizes multiple diffusions through gradient descent from a perceptual similarity loss. Specifically, we compute the gradient of the perceptual loss using the predicted denoised images at each denoising step, providing meaningful guidance for achieving coherent montages. Our experimental results demonstrate that our method produces significantly more coherent outputs compared to previous methods (66.35% vs. 33.65% in our user study) while still maintaining fidelity (as assessed by GIQA) and compatibility with the input prompt (as measured by CLIP score).

As neural networks grow in scale, their training becomes both computationally demanding and rich in dynamics. Amidst the flourishing interest in these training dynamics, we present a novel observation: Parameters during training exhibit intrinsic correlations over time. Capitalizing on this, we introduce Correlation Mode Decomposition (CMD). This algorithm clusters the parameter space into groups, termed modes, that display synchronized behavior across epochs. This enables CMD to efficiently represent the training dynamics of complex networks, like ResNets and Transformers, using only a few modes. Moreover, test set generalization is enhanced. We introduce an efficient CMD variant, designed to run concurrently with training. Our experiments indicate that CMD surpasses the state-of-the-art method for compactly modeled dynamics on image classification. Our modeling can improve training efficiency and lower communication overhead, as shown by our preliminary experiments in the context of federated learning.

This paper introduces a parallel and asynchronous Transformer framework designed for efficient and accurate multilingual lip synchronization in real-time video conferencing systems. The proposed architecture integrates translation, speech processing, and lip-synchronization modules within a pipeline-parallel design that enables concurrent module execution through message-queue-based decoupling, reducing end-to-end latency by up to 3.1 times compared to sequential approaches. To enhance computational efficiency and throughput, the inference workflow of each module is optimized through low-level graph compilation, mixed-precision quantization, and hardware-accelerated kernel fusion. These optimizations provide substantial gains in efficiency while preserving model accuracy and visual quality. In addition, a context-adaptive silence-detection component segments the input speech stream at semantically coherent boundaries, improving translation consistency and temporal alignment across languages. Experimental results demonstrate that the proposed parallel architecture outperforms conventional sequential pipelines in processing speed, synchronization stability, and resource utilization. The modular, message-oriented design makes this work applicable to resource-constrained IoT communication scenarios including telemedicine, multilingual kiosks, and remote assistance systems. Overall, this work advances the development of low-latency, resource-efficient multimodal communication frameworks for next-generation AIoT systems.

The bio-inspired event camera has garnered extensive research attention in recent years, owing to its significant potential derived from its high dynamic range and low latency characteristics. Similar to the standard camera, the event camera requires precise intrinsic calibration to facilitate further high-level visual applications, such as pose estimation and mapping. While several calibration methods for event cameras have been proposed, most of them are either (i) engineering-driven, heavily relying on conventional image-based calibration pipelines, or (ii) inconvenient, requiring complex instrumentation. To this end, we propose an accurate and convenient intrinsic calibration method for event cameras, named eKalibr, which builds upon a carefully designed event-based circle grid pattern recognition algorithm. To extract target patterns from events, we perform event-based normal flow estimation to identify potential events generated by circle edges, and cluster them spatially. Subsequently, event clusters associated with the same grid circles are matched and grouped using normal flows, for subsequent time-varying ellipse estimation. Fitted ellipse centers are time-synchronized, for final grid pattern recognition. We conducted extensive experiments to evaluate the performance of eKalibr in terms of pattern extraction and intrinsic calibration. The implementation of eKalibr is open-sourced at (https://github.com/Unsigned-Long/eKalibr) to benefit the research community.

Recent years have witnessed rapid progress in joint audio--visual generation. However, audio--visual synchronization remains a challenge, as generated speech and sound often temporally misalign with visual events. A key bottleneck is the lack of human-annotated data, reliable evaluation benchmarks, and synchronization-aware evaluation models for generated audio--visual outputs. To address these limitations, we conduct a comprehensive study spanning data, benchmarking, and reward modeling. We first introduce SyncReward-Data-80K, a dataset containing 80K professional synchronization ratings for clips from eight audio--visual generators. A taxonomy-guided construction pipeline covers four sound-event families: Speech, Onset, Instrument, and Ambient. We further construct SyncReward-Bench, a held-out benchmark of 1K clips, each independently rated by multiple professionals. Using this benchmark, we systematically evaluate specialized synchronization metrics and omni-modal models, revealing their substantial misalignment with human judgments. Finally, we develop SyncReward, a reward model that combines semantic--temporal contrastive pretraining on real clips with human supervision on generated clips. As an evaluation metric, SyncReward achieves the strongest agreement with human ratings among the evaluated methods. As a reward, it improves synchronization through inference-time best-of-N selection and reinforcement learning based post-training. We will release the data, benchmark, model, and code at https://github.com/WeChatCV/SyncReward.

In the task of talking face generation, the objective is to generate a face video with lips synchronized to the corresponding audio while preserving visual details and identity information. Current methods face the challenge of learning accurate lip synchronization while avoiding detrimental effects on visual quality, as well as robustly evaluating such synchronization. To tackle these problems, we propose utilizing an audio-visual speech representation expert (AV-HuBERT) for calculating lip synchronization loss during training. Moreover, leveraging AV-HuBERT's features, we introduce three novel lip synchronization evaluation metrics, aiming to provide a comprehensive assessment of lip synchronization performance. Experimental results, along with a detailed ablation study, demonstrate the effectiveness of our approach and the utility of the proposed evaluation metrics.

We propose a theoretical framework--Holographic Reservoir Computing (HRC)--which hypothesizes that the thermodynamic noise and timing dynamics in voltage-stressed Bitcoin mining ASICs (BM1366) could potentially serve as a physical reservoir computing substrate. We present the CHIMERA (Conscious Hybrid Intelligence via Miner-Embedded Resonance Architecture) system architecture, which treats the SHA-256 hashing pipeline not as an entropy source, but as a deterministic diffusion operator whose timing characteristics under controlled voltage and frequency conditions may exhibit computationally useful dynamics. We report preliminary observations of non-Poissonian variability in inter-arrival time statistics during edge-of-stability operation, which we term the "Silicon Heartbeat" hypothesis. Theoretical analysis based on Hierarchical Number System (HNS) representations suggests that such architectures could achieve O(log n) energy scaling compared to traditional von Neumann O(2^n) dependencies. However, we emphasize that these are theoretical projections requiring experimental validation. We present the implemented measurement infrastructure, acknowledge current limitations, and outline the experimental program necessary to confirm or refute these hypotheses. This work contributes to the emerging field of thermodynamic computing by proposing a novel approach to repurposing obsolete cryptographic hardware for neuromorphic applications.

In this work, a novel stack of well-known technologies is presented to determine an automatic method to segment the heart sounds in a phonocardiogram (PCG). We will show a deep recurrent neural network (DRNN) capable of segmenting a PCG into its main components and a very specific way of extracting instantaneous frequency that will play an important role in the training and testing of the proposed model. More specifically, it involves a Long Short-Term Memory (LSTM) neural network accompanied by the Fourier Synchrosqueezed Transform (FSST) used to extract instantaneous time-frequency features from a PCG. The present approach was tested on heart sound signals longer than 5 seconds and shorter than 35 seconds from freely-available databases. This approach proved that, with a relatively small architecture, a small set of data, and the right features, this method achieved an almost state-of-the-art performance, showing an average sensitivity of 89.5%, an average positive predictive value of 89.3\% and an average accuracy of 91.3%.

Closed-loop brain stimulation refers to capturing neurophysiological measures such as electroencephalography (EEG), quickly identifying neural events of interest, and producing auditory, magnetic or electrical stimulation so as to interact with brain processes precisely. It is a promising new method for fundamental neuroscience and perhaps for clinical applications such as restoring degraded memory function; however, existing tools are expensive, cumbersome, and offer limited experimental flexibility. In this article, we propose the Portiloop, a deep learning-based, portable and low-cost closed-loop stimulation system able to target specific brain oscillations. We first document open-hardware implementations that can be constructed from commercially available components. We also provide a fast, lightweight neural network model and an exploration algorithm that automatically optimizes the model hyperparameters to the desired brain oscillation. Finally, we validate the technology on a challenging test case of real-time sleep spindle detection, with results comparable to off-line expert performance on the Massive Online Data Annotation spindle dataset (MODA; group consensus). Software and plans are available to the community as an open science initiative to encourage further development and advance closed-loop neuroscience research.

In order to study oscillators coupled by pulses emitted at discrete times, it is generally assumed that the effect of each pulse is an instantaneous phase shift, with a possible conduction delay between emission and receipt. However, we are interested in neural oscillators in which each pulse (action potential) activates a biexponential synapse, and at high frequencies, the duration of the synaptic conductance may be greater than the network period. Therefore, the effect of received pulses can summate over the course of several cycles. To overcome this limitation, we previously defined a mean field approach for a single synchronous population. Here, we extend it to two alternating synchronous populations by assuming a perturbation of a single oscillator from one of the synchronous populations which is represented by a single self-connected neural oscillator. The train of delayed biexponential synapses emitted by each oscillator is divided into a tonic and a phasic component. Because of the continuous rather than pulsatile nature of the input, we had to drop the concept of oscillator phase and derive self-consistent criteria for the existence and stability of an alternating firing pattern between two synchronous populations based solely on the perturbation of time intervals from their steady state values. Simulations showed that for high frequency oscillations as defined above, the mean field approach predicts the existence and stability of phase-locking between two synchronous populations better than the instantaneous phase shift approach. This approach may generalize to other forms of coupling amongst non-neural oscillators.

Remote photoplethysmography (rPPG) is a non-contact method for detecting physiological signals based on facial videos, holding high potential in various applications. Due to the periodicity nature of rPPG signals, the long-range dependency capturing capacity of the transformer was assumed to be advantageous for such signals. However, existing methods have not conclusively demonstrated the superior performance of transformers over traditional convolutional neural networks. This may be attributed to the quadratic scaling exhibited by transformer with sequence length, resulting in coarse-grained feature extraction, which in turn affects robustness and generalization. To address that, this paper proposes a periodic sparse attention mechanism based on temporal attention sparsity induced by periodicity. A pre-attention stage is introduced before the conventional attention mechanism. This stage learns periodic patterns to filter out a large number of irrelevant attention computations, thus enabling fine-grained feature extraction. Moreover, to address the issue of fine-grained features being more susceptible to noise interference, a fusion stem is proposed to effectively guide self-attention towards rPPG features. It can be easily integrated into existing methods to enhance their performance. Extensive experiments show that the proposed method achieves state-of-the-art performance in both intra-dataset and cross-dataset evaluations. The codes are available at https://github.com/zizheng-guo/RhythmFormer.

The inherent synchronization between a speaker's lip movements, voice, and the underlying linguistic content offers a rich source of information for improving speech processing tasks, especially in challenging conditions where traditional audio-only systems falter. We introduce CoGenAV, a powerful and data-efficient model designed to learn versatile audio-visual representations applicable across a wide range of speech and audio-visual tasks. CoGenAV is trained by optimizing a dual objective derived from natural audio-visual synchrony, contrastive feature alignment and generative text prediction, using only 223 hours of labeled data from the LRS2 dataset. This contrastive-generative synchronization strategy effectively captures fundamental cross-modal correlations. We showcase the effectiveness and versatility of the learned CoGenAV representations on multiple benchmarks. When utilized for Audio-Visual Speech Recognition (AVSR) on LRS2, these representations contribute to achieving a state-of-the-art Word Error Rate (WER) of 1.27. They also enable strong performance in Visual Speech Recognition (VSR) with a WER of 22.0 on LRS2, and significantly improve performance in noisy environments by over 70%. Furthermore, CoGenAV representations benefit speech reconstruction tasks, boosting performance in Speech Enhancement and Separation, and achieve competitive results in audio-visual synchronization tasks like Active Speaker Detection (ASD). Our model will be open-sourced to facilitate further development and collaboration within both academia and industry.

Lip synchronization, known as the task of aligning lip movements in an existing video with new input audio, is typically framed as a simpler variant of audio-driven facial animation. However, as well as suffering from the usual issues in talking head generation (e.g., temporal consistency), lip synchronization presents significant new challenges such as expression leakage from the input video and facial occlusions, which can severely impact real-world applications like automated dubbing, but are often neglected in existing works. To address these shortcomings, we present KeySync, a two-stage framework that succeeds in solving the issue of temporal consistency, while also incorporating solutions for leakage and occlusions using a carefully designed masking strategy. We show that KeySync achieves state-of-the-art results in lip reconstruction and cross-synchronization, improving visual quality and reducing expression leakage according to LipLeak, our novel leakage metric. Furthermore, we demonstrate the effectiveness of our new masking approach in handling occlusions and validate our architectural choices through several ablation studies. Code and model weights can be found at https://antonibigata.github.io/KeySync.

This paper presents a novel real-time, delay-aware cooperative perception system designed for intelligent mobility platforms operating in dynamic indoor environments. The system contains a network of multi-modal sensor nodes and a central node that collectively provide perception services to mobility platforms. The proposed Hierarchical Clustering Considering the Scanning Pattern and Ground Contacting Feature based Lidar Camera Fusion improve intra-node perception for crowded environment. The system also features delay-aware global perception to synchronize and aggregate data across nodes. To validate our approach, we introduced the Indoor Pedestrian Tracking dataset, compiled from data captured by two indoor sensor nodes. Our experiments, compared to baselines, demonstrate significant improvements in detection accuracy and robustness against delays. The dataset is available in the repository: https://github.com/NingMingHao/MVSLab-IndoorCooperativePerception

Long-term forecasting of chaotic systems from short-term observations remains a fundamental and underexplored challenge due to the intrinsic sensitivity to initial conditions and the complex geometry of strange attractors. Existing approaches often rely on long-term training data or focus on short-term sequence correlations, struggling to maintain predictive stability and dynamical coherence over extended horizons. We propose PhyxMamba, a novel framework that integrates a Mamba-based state-space model with physics-informed principles to capture the underlying dynamics of chaotic systems. By reconstructing the attractor manifold from brief observations using time-delay embeddings, PhyxMamba extracts global dynamical features essential for accurate forecasting. Our generative training scheme enables Mamba to replicate the physical process, augmented by multi-token prediction and attractor geometry regularization for physical constraints, enhancing prediction accuracy and preserving key statistical invariants. Extensive evaluations on diverse simulated and real-world chaotic systems demonstrate that PhyxMamba delivers superior long-term forecasting and faithfully captures essential dynamical invariants from short-term data. This framework opens new avenues for reliably predicting chaotic systems under observation-scarce conditions, with broad implications across climate science, neuroscience, epidemiology, and beyond. Our code is open-source at https://github.com/tsinghua-fib-lab/PhyxMamba.

We present LatentSync, an end-to-end lip sync framework based on audio conditioned latent diffusion models without any intermediate motion representation, diverging from previous diffusion-based lip sync methods based on pixel space diffusion or two-stage generation. Our framework can leverage the powerful capabilities of Stable Diffusion to directly model complex audio-visual correlations. Additionally, we found that the diffusion-based lip sync methods exhibit inferior temporal consistency due to the inconsistency in the diffusion process across different frames. We propose Temporal REPresentation Alignment (TREPA) to enhance temporal consistency while preserving lip-sync accuracy. TREPA uses temporal representations extracted by large-scale self-supervised video models to align the generated frames with the ground truth frames. Furthermore, we observe the commonly encountered SyncNet convergence issue and conduct comprehensive empirical studies, identifying key factors affecting SyncNet convergence in terms of model architecture, training hyperparameters, and data preprocessing methods. We significantly improve the accuracy of SyncNet from 91% to 94% on the HDTF test set. Since we did not change the overall training framework of SyncNet, our experience can also be applied to other lip sync and audio-driven portrait animation methods that utilize SyncNet. Based on the above innovations, our method outperforms state-of-the-art lip sync methods across various metrics on the HDTF and VoxCeleb2 datasets.

Transfer entropy (TE) is an information theoretic measure that reveals the directional flow of information between processes, providing valuable insights for a wide range of real-world applications. This work proposes Transfer Entropy Estimation via Transformers (TREET), a novel attention-based approach for estimating TE for stationary processes. The proposed approach employs Donsker-Varadhan representation to TE and leverages the attention mechanism for the task of neural estimation. We propose a detailed theoretical and empirical study of the TREET, comparing it to existing methods on a dedicated estimation benchmark. To increase its applicability, we design an estimated TE optimization scheme that is motivated by the functional representation lemma, and use it to estimate the capacity of communication channels with memory, which is a canonical optimization problem in information theory. We further demonstrate how an optimized TREET can be used to estimate underlying densities, providing experimental results. Finally, we apply TREET to feature analysis of patients with Apnea, demonstrating its applicability to real-world physiological data. Our work, applied with state-of-the-art deep learning methods, opens a new door for communication problems which are yet to be solved.

Talking face generation aims to create realistic videos with accurate lip synchronization and high visual quality, using given audio and reference video while preserving identity and visual characteristics. In this paper, we start by identifying several issues with existing synchronization learning methods. These involve unstable training, lip synchronization, and visual quality issues caused by lip-sync loss, SyncNet, and lip leaking from the identity reference. To address these issues, we first tackle the lip leaking problem by introducing a silent-lip generator, which changes the lips of the identity reference to alleviate leakage. We then introduce stabilized synchronization loss and AVSyncNet to overcome problems caused by lip-sync loss and SyncNet. Experiments show that our model outperforms state-of-the-art methods in both visual quality and lip synchronization. Comprehensive ablation studies further validate our individual contributions and their cohesive effects.

We present CoInfra, a large-scale cooperative infrastructure perception system and dataset designed to advance robust multi-agent perception under real-world and adverse weather conditions. The CoInfra system includes 14 fully synchronized sensor nodes, each equipped with dual RGB cameras and a LiDAR, deployed across a shared region and operating continuously to capture all traffic participants in real-time. A robust, delay-aware synchronization protocol and a scalable system architecture that supports real-time data fusion, OTA management, and remote monitoring are provided in this paper. On the other hand, the dataset was collected in different weather scenarios, including sunny, rainy, freezing rain, and heavy snow and includes 195k LiDAR frames and 390k camera images from 8 infrastructure nodes that are globally time-aligned and spatially calibrated. Furthermore, comprehensive 3D bounding box annotations for five object classes (i.e., car, bus, truck, person, and bicycle) are provided in both global and individual node frames, along with high-definition maps for contextual understanding. Baseline experiments demonstrate the trade-offs between early and late fusion strategies, the significant benefits of HD map integration are discussed. By openly releasing our dataset, codebase, and system documentation at https://github.com/NingMingHao/CoInfra, we aim to enable reproducible research and drive progress in infrastructure-supported autonomous driving, particularly in challenging, real-world settings.

Sleep staging models often degrade when deployed on patients with unseen physiology or recording conditions. We propose a streaming, source-free test-time adaptation (TTA) recipe that combines entropy minimization (Tent) with Batch-Norm statistic refresh and two safety rails: an entropy gate to pause adaptation on uncertain windows and an EMA-based reset to reel back drift. On Sleep-EDF Expanded, using single-lead EEG (Fpz-Cz, 100 Hz, 30s epochs; R&K to AASM mapping), we show consistent gains over a frozen baseline at seconds-level latency and minimal memory, reporting per-stage metrics and Cohen's k. The method is model-agnostic, requires no source data or patient calibration, and is practical for on-device or bedside use.

We propose a novel nonlinear bidirectionally coupled heterogeneous chain network whose dynamics evolve in discrete time. The backbone of the model is a pair of popular map-based neuron models, the Chialvo and the Rulkov maps. This model is assumed to proximate the intricate dynamical properties of neurons in the widely complex nervous system. The model is first realized via various nonlinear analysis techniques: fixed point analysis, phase portraits, Jacobian matrix, and bifurcation diagrams. We observe the coexistence of chaotic and period-4 attractors. Various codimension-1 and -2 patterns for example saddle-node, period-doubling, Neimark-Sacker, double Neimark-Sacker, flip- and fold-Neimark Sacker, and 1:1 and 1:2 resonance are also explored. Furthermore, the study employs two synchronization measures to quantify how the oscillators in the network behave in tandem with each other over a long number of iterations. Finally, a time series analysis of the model is performed to investigate its complexity in terms of sample entropy.

Non-invasive continuous blood pressure (BP) monitoring using photoplethysmography (PPG) is a promising alternative to cuff-based measurements. However, existing PPG-based BP estimation studies predominantly rely on aggregated performance metrics (e.g., mean absolute error) computed over entire evaluation intervals, which can obscure model failures during rapid BP fluctuations and limit clinical relevance. In this work, we propose a fluctuation-aware evaluation framework for PPG-based BP estimation based on time-series change point detection. Instead of heuristic BP thresholding (e.g., ΔBP > 10mmHg), we identify BP change points by capturing abrupt distributional shifts in BP trajectories and evaluate estimation performance specifically during these fluctuation periods. Our analysis shows that several state-of-the-art models exhibit substantial performance degradation around BP change points, and that periodic test-time calibration is insufficient to handle such dynamic BP variations. To address this limitation, we introduce a targeted re-calibration framework triggered by detected BP change points, improving robustness without modifying model architectures. To the best of our knowledge, this is the first systematic evaluation of PPG-based BP estimation from a BP change point perspective, highlighting the importance of fluctuation-aware evaluation and calibration for real-world continuous BP monitoring.

Recurrent neural networks (RNNs) provide a powerful approach in neuroscience to infer latent dynamics in neural populations and to generate hypotheses about the neural computations underlying behavior. However, past work has focused on relatively simple, input-driven, and largely deterministic behaviors - little is known about the mechanisms that would allow RNNs to generate the richer, spontaneous, and potentially stochastic behaviors observed in natural settings. Modeling with Hidden Markov Models (HMMs) has revealed a segmentation of natural behaviors into discrete latent states with stochastic transitions between them, a type of dynamics that may appear at odds with the continuous state spaces implemented by RNNs. Here we first show that RNNs can replicate HMM emission statistics and then reverse-engineer the trained networks to uncover the mechanisms they implement. In the absence of inputs, the activity of trained RNNs collapses towards a single fixed point. When driven by stochastic input, trajectories instead exhibit noise-sustained dynamics along closed orbits. Rotation along these orbits modulates the emission probabilities and is governed by transitions between regions of slow, noise-driven dynamics connected by fast, deterministic transitions. The trained RNNs develop highly structured connectivity, with a small set of "kick neurons" initiating transitions between these regions. This mechanism emerges during training as the network shifts into a regime of stochastic resonance, enabling it to perform probabilistic computations. Analyses across multiple HMM architectures - fully connected, cyclic, and linear-chain - reveal that this solution generalizes through the modular reuse of the same dynamical motif, suggesting a compositional principle by which RNNs can emulate complex discrete latent dynamics.

Speaker clustering is the task of identifying the unique speakers in a set of audio recordings (each belonging to exactly one speaker) without knowing who and how many speakers are present in the entire data, which is essential for speaker diarization processes. Recently, off-the-shelf deep speaker embedding models have been leveraged to capture speaker characteristics. However, speeches containing emotional expressions pose significant challenges, often affecting the accuracy of speaker embeddings and leading to a decline in speaker clustering performance. To tackle this problem, we propose DTG-VAE, a novel disentanglement method that enhances clustering within a Variational Autoencoder (VAE) framework. This study reveals a direct link between emotional states and the effectiveness of deep speaker embeddings. As demonstrated in our experiments, DTG-VAE extracts more robust speaker embeddings and significantly enhances speaker clustering performance.

The detection and analysis of infant cry and snoring events are crucial tasks within the field of audio signal processing. While existing datasets for general sound event detection are plentiful, they often fall short in providing sufficient, strongly labeled data specific to infant cries and snoring. To provide a benchmark dataset and thus foster the research of infant cry and snoring detection, this paper introduces the Infant Cry and Snoring Detection (ICSD) dataset, a novel, publicly available dataset specially designed for ICSD tasks. The ICSD comprises three types of subsets: a real strongly labeled subset with event-based labels annotated manually, a weakly labeled subset with only clip-level event annotations, and a synthetic subset generated and labeled with strong annotations. This paper provides a detailed description of the ICSD creation process, including the challenges encountered and the solutions adopted. We offer a comprehensive characterization of the dataset, discussing its limitations and key factors for ICSD usage. Additionally, we conduct extensive experiments on the ICSD dataset to establish baseline systems and offer insights into the main factors when using this dataset for ICSD research. Our goal is to develop a dataset that will be widely adopted by the community as a new open benchmark for future ICSD research.

Electrocardiography (ECG), photoplethysmography (PPG), and phonocardiography (PCG) provide complementary views of the same cardiac cycle, yet existing cardiac foundation models are trained for a single sensing modality, leaving the shared physiology across sensors unexploited. We introduce CardioState-JEPA, a cardiac foundation model to learn a single shared representation jointly across ECG, PPG, and PCG, built on a physiology-aware joint-embedding predictive architecture. The model maps heterogeneous waveforms into a common token space, processes them with a single shared Transformer encoder, and learns by predicting masked latent cardiac states, placing the pretraining target on shared physiology rather than sensor-specific waveform appearance. To handle the temporal offsets between electrical, mechanical, and hemodynamic events, cross-modal prediction uses a learned delay aligner that matches signals at the corresponding cardiac time. Because synchronized multi-sensor recordings are scarce, CardioState-JEPA first learns within-modality structure from abundant unimodal data and then uses paired data to align modalities in latent cardiac time. Evaluated as a frozen encoder across 25 downstream tasks spanning ECG, PPG, and PCG, our encoder improves average PPG classification by 8.2 AUROC points, PCG murmur detection by 18.8 AUROC points, and ECG classification by 15.5 AUROC points over the best self-supervised signal baseline and matches or exceeds cardiac models trained with privileged clinical text or supervised labels on several ECG benchmarks. These results establish that heterogeneous cardiac signals can mutually supervise a single foundation model of cardiac physiology.

Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can discriminate Parkinsonian neural states. A comprehensive set of interpretable features was extracted and grouped into Standard descriptors (spectral power, phase synchronization, time-domain statistics) and Dynamical descriptors (aperiodic activity, cross-frequency coupling, scale-free dynamics, neuronal avalanche statistics, and instantaneous frequency measures). A multi-head attention transformer classifier was trained using strict LOSO validation. Group-level comparisons were performed to identify electrophysiological differences associated with disease and medication state. Standard feature sets achieved strongest performance in discriminating medication states (PDoff vs PDon), whereas Dynamical performed competitively in contrasts between PD patients and healthy controls. Random feature ablation analyses indicated that Dynamical descriptors provide complementary information distributed across features while correlation analysis revealed low redundancy within both feature sets. Group-level comparisons revealed medication-sensitive reductions in delta power and voltage variance, modulation of neuronal avalanche statistics, persistent increases in theta phase synchronization in PD patients, and disease-related alterations in cross-frequency interactions. Traditional spectral and synchronization features primarily reflect medication-related neural modulation, whereas dynamical descriptors reveal broader alterations in cortical network organization associated with disease but also with medication. These findings support multivariate EEG representations as a promising framework for developing non-invasive biomarkers of PD.

Introduction: Sleep staging is an essential component in the diagnosis of sleep disorders and management of sleep health. It is traditionally measured in a clinical setting and requires a labor-intensive labeling process. We hypothesize that it is possible to perform robust 4-class sleep staging using the raw photoplethysmography (PPG) time series and modern advances in deep learning (DL). Methods: We used two publicly available sleep databases that included raw PPG recordings, totalling 2,374 patients and 23,055 hours. We developed SleepPPG-Net, a DL model for 4-class sleep staging from the raw PPG time series. SleepPPG-Net was trained end-to-end and consists of a residual convolutional network for automatic feature extraction and a temporal convolutional network to capture long-range contextual information. We benchmarked the performance of SleepPPG-Net against models based on the best-reported state-of-the-art (SOTA) algorithms. Results: When benchmarked on a held-out test set, SleepPPG-Net obtained a median Cohen's Kappa (κ) score of 0.75 against 0.69 for the best SOTA approach. SleepPPG-Net showed good generalization performance to an external database, obtaining a κ score of 0.74 after transfer learning. Perspective: Overall, SleepPPG-Net provides new SOTA performance. In addition, performance is high enough to open the path to the development of wearables that meet the requirements for usage in clinical applications such as the diagnosis and monitoring of obstructive sleep apnea.

In this paper we introduce a new synchronisation task, Gesture-Sync: determining if a person's gestures are correlated with their speech or not. In comparison to Lip-Sync, Gesture-Sync is far more challenging as there is a far looser relationship between the voice and body movement than there is between voice and lip motion. We introduce a dual-encoder model for this task, and compare a number of input representations including RGB frames, keypoint images, and keypoint vectors, assessing their performance and advantages. We show that the model can be trained using self-supervised learning alone, and evaluate its performance on the LRS3 dataset. Finally, we demonstrate applications of Gesture-Sync for audio-visual synchronisation, and in determining who is the speaker in a crowd, without seeing their faces. The code, datasets and pre-trained models can be found at: https://www.robots.ox.ac.uk/~vgg/research/gestsync.

Longitudinal multimodal data, including electronic health records (EHR) and sequential chest X-rays (CXRs), is critical for modeling disease progression, yet remains underutilized due to two key challenges: (1) redundancy in consecutive CXR sequences, where static anatomical regions dominate over clinically-meaningful dynamics, and (2) temporal misalignment between sparse, irregular imaging and continuous EHR data. We introduce DiPro, a novel framework that addresses these challenges through region-aware disentanglement and multi-timescale alignment. First, we disentangle static (anatomy) and dynamic (pathology progression) features in sequential CXRs, prioritizing disease-relevant changes. Second, we hierarchically align these static and dynamic CXR features with asynchronous EHR data via local (pairwise interval-level) and global (full-sequence) synchronization to model coherent progression pathways. Extensive experiments on the MIMIC dataset demonstrate that DiPro could effectively extract temporal clinical dynamics and achieve state-of-the-art performance on both disease progression identification and general ICU prediction tasks.

This paper introduces JavisDiT, a novel Joint Audio-Video Diffusion Transformer designed for synchronized audio-video generation (JAVG). Built upon the powerful Diffusion Transformer (DiT) architecture, JavisDiT is able to generate high-quality audio and video content simultaneously from open-ended user prompts. To ensure optimal synchronization, we introduce a fine-grained spatio-temporal alignment mechanism through a Hierarchical Spatial-Temporal Synchronized Prior (HiST-Sypo) Estimator. This module extracts both global and fine-grained spatio-temporal priors, guiding the synchronization between the visual and auditory components. Furthermore, we propose a new benchmark, JavisBench, consisting of 10,140 high-quality text-captioned sounding videos spanning diverse scenes and complex real-world scenarios. Further, we specifically devise a robust metric for evaluating the synchronization between generated audio-video pairs in real-world complex content. Experimental results demonstrate that JavisDiT significantly outperforms existing methods by ensuring both high-quality generation and precise synchronization, setting a new standard for JAVG tasks. Our code, model, and dataset will be made publicly available at https://javisdit.github.io/.

We introduce a general framework for generating diverse visual content, including ambiguous images, panorama images, mesh textures, and Gaussian splat textures, by synchronizing multiple diffusion processes. We present exhaustive investigation into all possible scenarios for synchronizing multiple diffusion processes through a canonical space and analyze their characteristics across applications. In doing so, we reveal a previously unexplored case: averaging the outputs of Tweedie's formula while conducting denoising in multiple instance spaces. This case also provides the best quality with the widest applicability to downstream tasks. We name this case SyncTweedies. In our experiments generating visual content aforementioned, we demonstrate the superior quality of generation by SyncTweedies compared to other synchronization methods, optimization-based and iterative-update-based methods.

Four-dimensional cone-beam computed tomography (4D CBCT) provides respiration-resolved images and can be used for image-guided radiation therapy. However, the ability to reveal respiratory motion comes at the cost of image artifacts. As raw projection data are sorted into multiple respiratory phases, the cone-beam projections become much sparser and the reconstructed 4D CBCT images will be covered by severe streak artifacts. Although several deep learning-based methods have been proposed to address this issue, most algorithms employ 2D network models as backbones, neglecting the intrinsic structural priors within 4D CBCT images. In this paper, we first explore the origin and appearance of streak artifacts in 4D CBCT images. We find that streak artifacts exhibit a unique rotational motion along with the patient's respiration, distinguishable from diaphragm-driven respiratory motion in the spatiotemporal domain. Therefore, we propose a novel 4D neural network model, RSTAR4D-Net, designed to address Rotational STreak Artifact Reduction by integrating the spatial and temporal information within 4D CBCT images. Specifically, we overcome the computational and training difficulties of a 4D neural network. The specially designed model adopts an efficient implementation of 4D convolutions to reduce computational costs and thus can process the whole 4D image in one pass. Additionally, a Tetris training strategy pertinent to the separable 4D convolutions is proposed to effectively train the model using limited 4D training samples. Extensive experiments substantiate the effectiveness of our proposed method, and the RSTAR4D-Net shows superior performance compared to other methods. The source code and dynamic demos are available at https://github.com/ivy9092111111/RSTAR.

Deep clustering is the first method to handle general audio separation scenarios with multiple sources of the same type and an arbitrary number of sources, performing impressively in speaker-independent speech separation tasks. However, little is known about its effectiveness in other challenging situations such as music source separation. Contrary to conventional networks that directly estimate the source signals, deep clustering generates an embedding for each time-frequency bin, and separates sources by clustering the bins in the embedding space. We show that deep clustering outperforms conventional networks on a singing voice separation task, in both matched and mismatched conditions, even though conventional networks have the advantage of end-to-end training for best signal approximation, presumably because its more flexible objective engenders better regularization. Since the strengths of deep clustering and conventional network architectures appear complementary, we explore combining them in a single hybrid network trained via an approach akin to multi-task learning. Remarkably, the combination significantly outperforms either of its components.

Respiratory audio, such as coughing and breathing sounds, has predictive power for a wide range of healthcare applications, yet is currently under-explored. The main problem for those applications arises from the difficulty in collecting large labeled task-specific data for model development. Generalizable respiratory acoustic foundation models pretrained with unlabeled data would offer appealing advantages and possibly unlock this impasse. However, given the safety-critical nature of healthcare applications, it is pivotal to also ensure openness and replicability for any proposed foundation model solution. To this end, we introduce OPERA, an OPEn Respiratory Acoustic foundation model pretraining and benchmarking system, as the first approach answering this need. We curate large-scale respiratory audio datasets (~136K samples, 440 hours), pretrain three pioneering foundation models, and build a benchmark consisting of 19 downstream respiratory health tasks for evaluation. Our pretrained models demonstrate superior performance (against existing acoustic models pretrained with general audio on 16 out of 19 tasks) and generalizability (to unseen datasets and new respiratory audio modalities). This highlights the great promise of respiratory acoustic foundation models and encourages more studies using OPERA as an open resource to accelerate research on respiratory audio for health. The system is accessible from https://github.com/evelyn0414/OPERA.

Online surgical phase recognition (SPR) underpins context-aware operating-room systems and requires committing to a prediction at every frame from past context alone. Surgical video poses three demands that natural-video recognizers do not jointly address: procedures span tens of thousands of frames, time flows non-uniformly as long routine stretches are punctuated by brief phase-defining transitions, and the visual domain is narrow so backbone features are strongly correlated across channels. Existing recognizers either let per-frame cost grow with elapsed length, or hold cost bounded but advance state at a uniform rate with channel-independent dynamics, leaving the latter two demands unaddressed. We present SurgicalMamba, a causal SPR model built on Mamba2's structured state-space duality (SSD) that holds per-frame cost at O(d). It introduces three SSD-compatible components, each targeting one demand: a dual-path SSD block that separates long- and short-term regimes at the level of recurrent state; intensity-modulated stepping, a continuous-time time-warp that adapts the slow path's effective rate to phase-relevant information; and state regramming, a per-chunk Cayley rotation that opens cross-channel mixing in the otherwise axis-aligned SSM recurrence. The learned rotation planes inherit a phase-aligned structure without any direct supervision, offering an interpretable internal signature of surgical workflow. Across seven public SPR benchmarks, SurgicalMamba reaches state-of-the-art accuracy and phase-level Jaccard under strict online evaluation: 94.6%/82.7% on Cholec80 (+0.7 pp/+2.2 pp over the strongest prior) and 89.5%/68.9% on AutoLaparo (+1.7 pp/+2.0 pp), at 119 fps on a single GPU. Ablations isolate the contribution of each component. The code is publicly available at https://github.com/sukjuoh/Surgical-Mamba.

We propose 4Real-Video, a novel framework for generating 4D videos, organized as a grid of video frames with both time and viewpoint axes. In this grid, each row contains frames sharing the same timestep, while each column contains frames from the same viewpoint. We propose a novel two-stream architecture. One stream performs viewpoint updates on columns, and the other stream performs temporal updates on rows. After each diffusion transformer layer, a synchronization layer exchanges information between the two token streams. We propose two implementations of the synchronization layer, using either hard or soft synchronization. This feedforward architecture improves upon previous work in three ways: higher inference speed, enhanced visual quality (measured by FVD, CLIP, and VideoScore), and improved temporal and viewpoint consistency (measured by VideoScore and Dust3R-Confidence).

We introduce a new heuristic decoder, Relay-BP, targeting real-time quantum circuit decoding for large-scale quantum computers. Relay-BP achieves high accuracy across circuit-noise decoding problems: significantly outperforming BP+OSD+CS-10 for bivariate-bicycle codes and comparable to min-weight-matching for surface codes. As a lightweight message-passing decoder, Relay-BP is inherently parallel, enabling rapid low-footprint decoding with FPGA or ASIC real-time implementations, similar to standard BP. A core aspect of our decoder is its enhancement of the standard BP algorithm by incorporating disordered memory strengths. This dampens oscillations and breaks symmetries that trap traditional BP algorithms. By dynamically adjusting memory strengths in a relay approach, Relay-BP can consecutively encounter multiple valid corrections to improve decoding accuracy. We observe that a problem-dependent distribution of memory strengths that includes negative values is indispensable for good performance.

Multi-agent large language model (LLM) systems often rely on verifier and critic agents to suppress hallucinations, but verification is delayed. During this delay, false claims can propagate through the agent network. We model this process as delayed consensus on a graph with grounded corrector nodes. Spectral decomposition by the grounded Laplacian yields a closed-form stability threshold for the verification dose: correction that is too strong or too delayed can turn consensus into oscillation. The most unstable regime occurs when the communication and verification delays coincide; for delay two, the threshold is the inverse golden ratio. The same framework gives a supermodular placement objective and a greedy (1-1/e)-approximation rule for assigning a limited corrector budget to influential nodes. Experiments across five open models confirm the predicted dose-delay oscillations. By contrast, grounded factual answering makes truth an absorbing boundary and eliminates the effect, suggesting that the instability is specific to signed-belief tasks while grounded verification remains stabilizing

Endoscopic Submucosal Dissection (ESD) is a minimally invasive procedure initially developed for early gastric cancer treatment and has expanded to address diverse gastrointestinal lesions. While computer-assisted surgery (CAS) systems enhance ESD precision and safety, their efficacy hinges on accurate real-time surgical phase recognition, a task complicated by ESD's inherent complexity, including heterogeneous lesion characteristics and dynamic tissue interactions. Existing video-based phase recognition algorithms, constrained by inefficient temporal context modeling, exhibit limited performance in capturing fine-grained phase transitions and long-range dependencies. To overcome these limitations, we propose SPRMamba, a novel framework integrating a Mamba-based architecture with a Scaled Residual TranMamba (SRTM) block to synergize long-term temporal modeling and localized detail extraction. SPRMamba further introduces the Hierarchical Sampling Strategy to optimize computational efficiency, enabling real-time processing critical for clinical deployment. Evaluated on the ESD385 dataset and the cholecystectomy benchmark Cholec80, SPRMamba achieves state-of-the-art performance (87.64% accuracy on ESD385, +1.0% over prior methods), demonstrating robust generalizability across surgical workflows. This advancement bridges the gap between computational efficiency and temporal sensitivity, offering a transformative tool for intraoperative guidance and skill assessment in ESD surgery. The code is accessible at https://github.com/Zxnyyyyy/SPRMamba.

Clustering is a widely used unsupervised learning technique involving an intensive discrete optimization problem. Associative Memory models or AMs are differentiable neural networks defining a recursive dynamical system, which have been integrated with various deep learning architectures. We uncover a novel connection between the AM dynamics and the inherent discrete assignment necessary in clustering to propose a novel unconstrained continuous relaxation of the discrete clustering problem, enabling end-to-end differentiable clustering with AM, dubbed ClAM. Leveraging the pattern completion ability of AMs, we further develop a novel self-supervised clustering loss. Our evaluations on varied datasets demonstrate that ClAM benefits from the self-supervision, and significantly improves upon both the traditional Lloyd's k-means algorithm, and more recent continuous clustering relaxations (by upto 60% in terms of the Silhouette Coefficient).

This study concentrates on evaluating the efficacy of Large Language Models (LLMs) in healthcare, with a specific focus on their application in personal anomalous health monitoring. Our research primarily investigates the capabilities of LLMs in interpreting and analyzing physiological data obtained from FDA-approved devices. We conducted an extensive analysis using anomalous physiological data gathered in a simulated low-air-pressure plateau environment. This allowed us to assess the precision and reliability of LLMs in understanding and evaluating users' health status with notable specificity. Our findings reveal that LLMs exhibit exceptional performance in determining medical indicators, including a Mean Absolute Error (MAE) of less than 1 beat per minute for heart rate and less than 1% for oxygen saturation (SpO2). Furthermore, the Mean Absolute Percentage Error (MAPE) for these evaluations remained below 1%, with the overall accuracy of health assessments surpassing 85%. In image analysis tasks, such as interpreting photoplethysmography (PPG) data, our specially adapted GPT models demonstrated remarkable proficiency, achieving less than 1 bpm error in cycle count and 7.28 MAE for heart rate estimation. This study highlights LLMs' dual role as health data analysis tools and pivotal elements in advanced AI health assistants, offering personalized health insights and recommendations within the future health assistant framework.

The synthesis of synchronized audio-visual content is a key challenge in generative AI, with open-source models facing challenges in robust audio-video alignment. Our analysis reveals that this issue is rooted in three fundamental challenges of the joint diffusion process: (1) Correspondence Drift, where concurrently evolving noisy latents impede stable learning of alignment; (2) inefficient global attention mechanisms that fail to capture fine-grained temporal cues; and (3) the intra-modal bias of conventional Classifier-Free Guidance (CFG), which enhances conditionality but not cross-modal synchronization. To overcome these challenges, we introduce Harmony, a novel framework that mechanistically enforces audio-visual synchronization. We first propose a Cross-Task Synergy training paradigm to mitigate drift by leveraging strong supervisory signals from audio-driven video and video-driven audio generation tasks. Then, we design a Global-Local Decoupled Interaction Module for efficient and precise temporal-style alignment. Finally, we present a novel Synchronization-Enhanced CFG (SyncCFG) that explicitly isolates and amplifies the alignment signal during inference. Extensive experiments demonstrate that Harmony establishes a new state-of-the-art, significantly outperforming existing methods in both generation fidelity and, critically, in achieving fine-grained audio-visual synchronization.

Time series play a fundamental role in many domains, capturing a plethora of information about the underlying data-generating processes. When a process generates multiple synchronized signals we are faced with multidimensional time series. In this context a fundamental problem is that of motif mining, where we seek patterns repeating twice with minor variations, spanning some of the dimensions. State of the art exact solutions for this problem run in time quadratic in the length of the input time series. We provide a scalable method to find the top-k motifs in multidimensional time series with probabilistic guarantees on the quality of the results. Our algorithm runs in time subquadratic in the length of the input, and returns the exact solution with probability at least 1-δ, where δ is a user-defined parameter. The algorithm is designed to be adaptive to the input distribution, self-tuning its parameters while respecting user-defined limits on the memory to use. Our theoretical analysis is complemented by an extensive experimental evaluation, showing that our algorithm is orders of magnitude faster than the state of the art.

We present an algorithmic framework for incremental maintenance of first sheaf cohomology H^1(X; F) on dynamically evolving 1-dimensional cellular complexes equipped with finite-dimensional cellular sheaves. The classical computation of H^1 via factorization of the coboundary matrix requires O(n^3) time; when the complex evolves with a stream of m edits, full recomputation after each edit costs O(mn^3). Under a bounded local geometry assumption -- bounded cell size v_{max}, bounded stalk dimension d, and bounded nerve degree D -- each edit (vertex insertion, edge insertion, restriction map update) affects only a bounded set of local coboundary blocks. The algorithm therefore processes lazy streaming edits in O(1) time with respect to the total complex size n (with cost polynomial in the local geometry parameters v_{max}, d, and D, which are treated as constants independent of n), deferring local eigensolves and Mayer-Vietoris global assembly to synchronization points (Flush). At synchronization, the maintained state agrees with the corresponding batch assembly of the partitioned sheaf model; we observe zero measured drift in all batch-verified runs (through V = 10^6). We also give an amortized O(|E|) streaming construction for the cellular decomposition and discuss an adversarial algebraic-RAM barrier arguing that unpartitioned non-trivial sheaves (d geq 2, non-identity restriction maps) do not admit the same locality. Experiments on Barabasi-Albert graphs with up to 5 times 10^6 vertices and 1.7 times 10^7 streaming edits show 35 μs median lazy per-edit update latency (excluding flush); query time (global assembly at synchronization) is O(n) per flush in the implemented full-traversal path. Exact synchronization costs are reported separately.

The problem of robotic synchronisation and coordination is a long-standing one. Combining autonomous, computerised systems with unpredictable real-world conditions can have consequences ranging from poor performance to collisions and damage. This paper proposes using coupled oscillators to create a drone swarm that is decentralised and self organising. This allows for greater flexibility and adaptiveness than a hard-coded swarm, with more resilience and scalability than a centralised system. Our method allows for a variable number of drones to spontaneously form a swarm and react to changing swarm conditions. Additionally, this method includes provisions to prevent communication interference between drones, and signal processing techniques to ensure a smooth and cohesive swarm.

We develop a multi-rate distributed unscented Kalman filter for nonlinear networks without a fusion center. Local continuous-discrete UKFs run on a common base grid, update at their own sampling instants, and exchange estimates within one-hop neighborhoods. Under a windowed collective-detectability condition, diffusion of information matrices gives uniformly bounded quotient covariances although no individual node need be observable. When the collectively invisible subspace is trivial and the statistical-linearization discrepancies satisfy an explicit coherence bound, the information weighted fused mean yields exponentially bounded mean-square errors without a contraction-mixing condition. This contrasts with the arithmetic diffusiojn mean, which requires one. A distributed H_{infty} variant uses a fixed attenuation penalty. A finite-prefix feasibility check and the one-hop detectability Gramian yield a uniform regularized-information margin - an explicit local-contraction-mixing condition then yields mean-square error boundedness. The developed methods are tested on a stochastic nonlinear benchmark and a three-inertia network in which every node misses at least one mode. Information diffusion is more accurate than five-round covariance-averaging consensus at one fifth of its communication. It remains stable under 3:2 multi-rate sampling, where the covariance-averaging consensus and the diffusion mean both diverge, and it keeps the quotient covariances bounded.

Vibration-based condition monitoring systems are receiving increasing attention due to their ability to accurately identify different conditions by capturing dynamic features over a broad frequency range. However, there is little research on clustering approaches in vibration data and the resulting solutions are often optimized for a single data set. In this work, we present an extensive comparison of the clustering algorithms K-means clustering, OPTICS, and Gaussian mixture model clustering (GMM) applied to statistical features extracted from the time and frequency domains of vibration data sets. Furthermore, we investigate the influence of feature combinations, feature selection using principal component analysis (PCA), and the specified number of clusters on the performance of the clustering algorithms. We conducted this comparison in terms of a grid search using three different benchmark data sets. Our work showed that averaging (Mean, Median) and variance-based features (Standard Deviation, Interquartile Range) performed significantly better than shape-based features (Skewness, Kurtosis). In addition, K-means outperformed GMM slightly for these data sets, whereas OPTICS performed significantly worse. We were also able to show that feature combinations as well as PCA feature selection did not result in any significant performance improvements. With an increase in the specified number of clusters, clustering algorithms performed better, although there were some specific algorithmic restrictions.

Latent diffusion models (LDMs) have recently achieved strong performance in 3D medical image synthesis. However, modalities like cine cardiac MRI (CMR), representing a temporally synchronized 3D volume across the cardiac cycle, add an additional dimension that most generative approaches do not model directly. Instead, they factorize space and time or enforce temporal consistency through auxiliary mechanisms such as anatomical masks. Such strategies introduce structural biases that may limit global context integration and lead to subtle spatiotemporal discontinuities or physiologically inconsistent cardiac dynamics. We investigate whether a unified 4D generative model can learn continuous cardiac dynamics without architectural factorization. We propose CardioDiT, a fully 4D latent diffusion framework for short-axis cine CMR synthesis based on diffusion transformers. A spatiotemporal VQ-VAE encodes 2D+t slices into compact latents, which a diffusion transformer then models jointly as complete 3D+t volumes, coupling space and time throughout the generative process. We evaluate CardioDiT on public CMR datasets and a larger private cohort, comparing it to baselines with progressively stronger spatiotemporal coupling. Results show improved inter-slice consistency, temporally coherent motion, and realistic cardiac function distributions, suggesting that explicit 4D modeling with a diffusion transformer provides a principled foundation for spatiotemporal cardiac image synthesis. Code and models trained on public data are available at https://github.com/Cardio-AI/cardiodit.

A network-based approach is presented to investigate the cerebrovascular flow patterns during atrial fibrillation (AF) with respect to normal sinus rhythm (NSR). AF, the most common cardiac arrhythmia with faster and irregular beating, has been recently and independently associated with the increased risk of dementia. However, the underlying hemodynamic mechanisms relating the two pathologies remain mainly undetermined so far; thus the contribution of modeling and refined statistical tools is valuable. Pressure and flow rate temporal series in NSR and AF are here evaluated along representative cerebral sites (from carotid arteries to capillary brain circulation), exploiting reliable artificially built signals recently obtained from an in silico approach. The complex network analysis evidences, in a synthetic and original way, a dramatic signal variation towards the distal/capillary cerebral regions during AF, which has no counterpart in NSR conditions. At the large artery level, networks obtained from both AF and NSR hemodynamic signals exhibit elongated and chained features, which are typical of pseudo-periodic series. These aspects are almost completely lost towards the microcirculation during AF, where the networks are topologically more circular and present random-like characteristics. As a consequence, all the physiological phenomena at microcerebral level ruled by periodicity - such as regular perfusion, mean pressure per beat, and average nutrient supply at cellular level - can be strongly compromised, since the AF hemodynamic signals assume irregular behaviour and random-like features. Through a powerful approach which is complementary to the classical statistical tools, the present findings further strengthen the potential link between AF hemodynamic and cognitive decline.

While automated sleep staging has achieved expert-level accuracy, its clinical adoption is hindered by a lack of auditable reasoning. We introduce SleepVLM, a rule-grounded vision-language model (VLM) designed to stage sleep from multi-channel polysomnography (PSG) waveform images while generating clinician-readable rationales based on American Academy of Sleep Medicine (AASM) scoring criteria. Utilizing waveform-perceptual pre-training and rule-grounded supervised fine-tuning, SleepVLM achieved Cohen's kappa scores of 0.767 on an held out test set (MASS-SS1) and 0.743 on an external cohort (ZUAMHCS), matching state-of-the-art performance. Expert evaluations further validated the quality of the model's reasoning, with mean scores exceeding 4.0/5.0 for factual accuracy, evidence comprehensiveness, and logical coherence. By coupling competitive performance with transparent, rule-based explanations, SleepVLM may improve the trustworthiness and auditability of automated sleep staging in clinical workflows. To facilitate further research in interpretable sleep medicine, we release MASS-EX, a novel expert-annotated dataset.

Sonification -- the mapping of data to non-speech audio -- offers an underexplored channel for representing complex dynamical systems. We treat El Niño-Southern Oscillation (ENSO), a canonical example of low-dimensional climate chaos, as a test case for culturally-situated sonification evaluated through complex systems diagnostics. Using parameter-mapping sonification of the Niño 3.4 sea surface temperature anomaly index (1870--2024), we encode ENSO variability into two traditional Javanese gamelan pentatonic systems (pelog and slendro) across four composition strategies, then analyze the resulting audio as trajectories in a two-dimensional acoustic phase space. Recurrence-based diagnostics, convex hull geometry, and coupling analysis reveal that the sonification pipeline preserves key dynamical signatures: alternating modes produce the highest trajectory recurrence rates, echoing ENSO's quasi-periodicity; layered polyphonic modes explore the broadest phase space regions; and the two scale families induce qualitatively distinct coupling regimes between spectral brightness and energy -- predominantly anti-phase in pelog but near-independent in slendro. Phase space trajectory analysis provides a rigorous geometric framework for comparing sonification designs within a complex systems context. Perceptual validation remains necessary; we contribute the dynamical systems methodology for evaluating such mappings.

Despite broad interest in modeling spoken dialogue agents, most approaches are inherently "half-duplex" -- restricted to turn-based interaction with responses requiring explicit prompting by the user or implicit tracking of interruption or silence events. Human dialogue, by contrast, is "full-duplex" allowing for rich synchronicity in the form of quick and dynamic turn-taking, overlapping speech, and backchanneling. Technically, the challenge of achieving full-duplex dialogue with LLMs lies in modeling synchrony as pre-trained LLMs do not have a sense of "time". To bridge this gap, we propose Synchronous LLMs for full-duplex spoken dialogue modeling. We design a novel mechanism to integrate time information into Llama3-8b so that they run synchronously with the real-world clock. We also introduce a training recipe that uses 212k hours of synthetic spoken dialogue data generated from text dialogue data to create a model that generates meaningful and natural spoken dialogue, with just 2k hours of real-world spoken dialogue data. Synchronous LLMs outperform state-of-the-art in dialogue meaningfulness while maintaining naturalness. Finally, we demonstrate the model's ability to participate in full-duplex dialogue by simulating interaction between two agents trained on different datasets, while considering Internet-scale latencies of up to 240 ms. Webpage: https://syncllm.cs.washington.edu/.

The complexity and heterogeneity of data in many real-world applications pose significant challenges for traditional machine learning and signal processing techniques. For instance, in medicine, effective analysis of diverse physiological signals is crucial for patient monitoring and clinical decision-making and yet highly challenging. We introduce MedTsLLM, a general multimodal large language model (LLM) framework that effectively integrates time series data and rich contextual information in the form of text to analyze physiological signals, performing three tasks with clinical relevance: semantic segmentation, boundary detection, and anomaly detection in time series. These critical tasks enable deeper analysis of physiological signals and can provide actionable insights for clinicians. We utilize a reprogramming layer to align embeddings of time series patches with a pretrained LLM's embedding space and make effective use of raw time series, in conjunction with textual context. Given the multivariate nature of medical datasets, we develop methods to handle multiple covariates. We additionally tailor the text prompt to include patient-specific information. Our model outperforms state-of-the-art baselines, including deep learning models, other LLMs, and clinical methods across multiple medical domains, specifically electrocardiograms and respiratory waveforms. MedTsLLM presents a promising step towards harnessing the power of LLMs for medical time series analysis that can elevate data-driven tools for clinicians and improve patient outcomes.

Accurate sleep staging is essential for diagnosing OSA and hypopnea in stroke patients. Although PSG is reliable, it is costly, labor-intensive, and manually scored. While deep learning enables automated EEG-based sleep staging in healthy subjects, our analysis shows poor generalization to clinical populations with disrupted sleep. Using Grad-CAM interpretations, we systematically demonstrate this limitation. We introduce iSLEEPS, a newly clinically annotated ischemic stroke dataset (to be publicly released), and evaluate a SE-ResNet plus bidirectional LSTM model for single-channel EEG sleep staging. As expected, cross-domain performance between healthy and diseased subjects is poor. Attention visualizations, supported by clinical expert feedback, show the model focuses on physiologically uninformative EEG regions in patient data. Statistical and computational analyses further confirm significant sleep architecture differences between healthy and ischemic stroke cohorts, highlighting the need for subject-aware or disease-specific models with clinical validation before deployment. A summary of the paper and the code is available at https://himalayansaswatabose.github.io/iSLEEPS_Explainability.github.io/

Clustering is a NP-hard problem. Thus, no optimal algorithm exists, heuristics are applied to cluster the data. Heuristics can be very resource-intensive, if not applied properly. For substantially large data sets computational efficiencies can be achieved by reducing the input space if a minimal loss of information can be achieved. Clustering algorithms, in general, face two common problems: 1) these converge to different settings with different initial conditions and; 2) the number of clusters has to be arbitrarily decided beforehand. This problem has become critical in the realm of big data. Recently, clustering algorithms have emerged which can speedup computations using parallel processing over the grid but face the aforementioned problems. Goals: Our goals are to find methods to cluster data which: 1) guarantee convergence to the same settings irrespective of the initial conditions; 2) eliminate the need to establish the number of clusters beforehand, and 3) can be applied to cluster large datasets. Methods: We introduce a method that combines probabilistic and combinatorial clustering methods to produce repeatable and compact clusters that are not sensitive to initial conditions. This method harnesses the power of k-means (a combinatorial clustering method) to cluster/partition very large dimensional datasets and uses the Gaussian Mixture Model (a probabilistic clustering method) to validate the k-means partitions. Results: We show that this method produces very compact clusters that are not sensitive to initial conditions. This method can be used to identify the most 'separable' set in a dataset which increases the 'clusterability' of a dataset. This method also eliminates the need to specify the number of clusters in advance.

Exact firing rate models, also known as next-generation neural mass models (NG-NMMs), provide a rigorous description of the dynamics of neural populations. While in its simplest form a single population only displays fixed-point activity, multi-population models may display a range of different behaviors. In this work, we study the dynamics of all-excitatory or all-inhibitory NG-NMMs coupled through sparse random networks with row-normalized network topology. Linear stability analysis of the homogeneous states of the system, representing asynchronous neural activity, provides a dispersion relation linking the emergence of spatiotemporal dynamics to the spectra of the connectivity matrix. Using bounds from random matrix theory, we identify the parameter regions where instabilities occur. In undirected networks, only inhibitory systems produce heterogeneous stationary patterns, corresponding to a winner-takes-all mechanism. In directed networks, exotic rhythmic states with high frequencies emerge in both, excitatory and inhibitory systems. Numerical simulations reveal that these hectic oscillatory states correspond to high-dimensional chaos with extensive properties.

Many applications need up-to-date copies of collections of changing Web resources. Such synchronization is currently achieved using ad-hoc or proprietary solutions. We propose ResourceSync, a general Web resource synchronization protocol that leverages XML Sitemaps. It provides a set of capabilities that can be combined in a modular manner to meet local or community requirements. We report on work to implement this protocol for arXiv.org and also provide an experimental prototype for the English Wikipedia as well as a client API.

The COVID-19 pandemic presents global challenges transcending boundaries of country, race, religion, and economy. The current gold standard method for COVID-19 detection is the reverse transcription polymerase chain reaction (RT-PCR) testing. However, this method is expensive, time-consuming, and violates social distancing. Also, as the pandemic is expected to stay for a while, there is a need for an alternate diagnosis tool which overcomes these limitations, and is deployable at a large scale. The prominent symptoms of COVID-19 include cough and breathing difficulties. We foresee that respiratory sounds, when analyzed using machine learning techniques, can provide useful insights, enabling the design of a diagnostic tool. Towards this, the paper presents an early effort in creating (and analyzing) a database, called Coswara, of respiratory sounds, namely, cough, breath, and voice. The sound samples are collected via worldwide crowdsourcing using a website application. The curated dataset is released as open access. As the pandemic is evolving, the data collection and analysis is a work in progress. We believe that insights from analysis of Coswara can be effective in enabling sound based technology solutions for point-of-care diagnosis of respiratory infection, and in the near future this can help to diagnose COVID-19.

The most popular framework for distributed training of machine learning models is the (synchronous) parameter server (PS). This paradigm consists of n workers, which iteratively compute updates of the model parameters, and a stateful PS, which waits and aggregates all updates to generate a new estimate of model parameters and sends it back to the workers for a new iteration. Transient computation slowdowns or transmission delays can intolerably lengthen the time of each iteration. An efficient way to mitigate this problem is to let the PS wait only for the fastest n-b updates, before generating the new parameters. The slowest b workers are called backup workers. The optimal number b of backup workers depends on the cluster configuration and workload, but also (as we show in this paper) on the hyper-parameters of the learning algorithm and the current stage of the training. We propose DBW, an algorithm that dynamically decides the number of backup workers during the training process to maximize the convergence speed at each iteration. Our experiments show that DBW 1) removes the necessity to tune b by preliminary time-consuming experiments, and 2) makes the training up to a factor 3 faster than the optimal static configuration.