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Feb 2

DRQA: Dynamic Reasoning Quota Allocation for Controlling Overthinking in Reasoning Large Language Models

Reasoning large language models (RLLMs), such as OpenAI-O3 and DeepSeek-R1, have recently demonstrated remarkable capabilities by performing structured and multi-step reasoning. However, recent studies reveal that RLLMs often suffer from overthinking, i.e., producing unnecessarily lengthy reasoning chains even for simple questions, leading to excessive token consumption and computational inefficiency. Interestingly, we observe that when processing multiple questions in batch mode, RLLMs exhibit more resource-efficient behavior by dynamically compressing reasoning steps for easier problems, due to implicit resource competition. Inspired by this, we propose Dynamic Reasoning Quota Allocation (DRQA), a novel method that transfers the benefits of resource competition from batch processing to single-question inference. Specifically, DRQA leverages batch-generated preference data and reinforcement learning to train the model to allocate reasoning resources adaptively. By encouraging the model to internalize a preference for responses that are both accurate and concise, DRQA enables it to generate concise answers for simple questions while retaining sufficient reasoning depth for more challenging ones. Extensive experiments on a wide range of mathematical and scientific reasoning benchmarks demonstrate that DRQA significantly reduces token usage while maintaining, and in many cases improving, answer accuracy. By effectively mitigating the overthinking problem, DRQA offers a promising direction for more efficient and scalable deployment of RLLMs, and we hope it inspires further exploration into fine-grained control of reasoning behaviors.

  • 6 authors
·
Aug 25, 2025

Supernova Event Dataset: Interpreting Large Language Model's Personality through Critical Event Analysis

Large Language Models (LLMs) are increasingly integrated into everyday applications. As their influence grows, understanding their decision making and underlying personality becomes essential. In this work, we interpret model personality using our proposed Supernova Event Dataset, a novel dataset with diverse articles spanning biographies, historical events, news, and scientific discoveries. We use this dataset to benchmark LLMs on extracting and ranking key events from text, a subjective and complex challenge that requires reasoning over long-range context and modeling causal chains. We evaluate small models like Phi-4, Orca 2, and Qwen 2.5, and large, stronger models such as Claude 3.7, Gemini 2.5, and OpenAI o3, and propose a framework where another LLM acts as a judge to infer each model's personality based on its selection and classification of events. Our analysis shows distinct personality traits: for instance, Orca 2 demonstrates emotional reasoning focusing on interpersonal dynamics, while Qwen 2.5 displays a more strategic, analytical style. When analyzing scientific discovery events, Claude Sonnet 3.7 emphasizes conceptual framing, Gemini 2.5 Pro prioritizes empirical validation, and o3 favors step-by-step causal reasoning. This analysis improves model interpretability, making them user-friendly for a wide range of diverse applications.

  • 2 authors
·
Jun 13, 2025 2

EasyTPP: Towards Open Benchmarking Temporal Point Processes

Continuous-time event sequences play a vital role in real-world domains such as healthcare, finance, online shopping, social networks, and so on. To model such data, temporal point processes (TPPs) have emerged as the most natural and competitive models, making a significant impact in both academic and application communities. Despite the emergence of many powerful models in recent years, there hasn't been a central benchmark for these models and future research endeavors. This lack of standardization impedes researchers and practitioners from comparing methods and reproducing results, potentially slowing down progress in this field. In this paper, we present EasyTPP, the first central repository of research assets (e.g., data, models, evaluation programs, documentations) in the area of event sequence modeling. Our EasyTPP makes several unique contributions to this area: a unified interface of using existing datasets and adding new datasets; a wide range of evaluation programs that are easy to use and extend as well as facilitate reproducible research; implementations of popular neural TPPs, together with a rich library of modules by composing which one could quickly build complex models. All the data and implementation can be found at https://github.com/ant-research/EasyTemporalPointProcess. We will actively maintain this benchmark and welcome contributions from other researchers and practitioners. Our benchmark will help promote reproducible research in this field, thus accelerating research progress as well as making more significant real-world impacts.

  • 12 authors
·
Jul 16, 2023

Modeling Inter-Dependence Between Time and Mark in Multivariate Temporal Point Processes

Temporal Point Processes (TPP) are probabilistic generative frameworks. They model discrete event sequences localized in continuous time. Generally, real-life events reveal descriptive information, known as marks. Marked TPPs model time and marks of the event together for practical relevance. Conditioned on past events, marked TPPs aim to learn the joint distribution of the time and the mark of the next event. For simplicity, conditionally independent TPP models assume time and marks are independent given event history. They factorize the conditional joint distribution of time and mark into the product of individual conditional distributions. This structural limitation in the design of TPP models hurt the predictive performance on entangled time and mark interactions. In this work, we model the conditional inter-dependence of time and mark to overcome the limitations of conditionally independent models. We construct a multivariate TPP conditioning the time distribution on the current event mark in addition to past events. Besides the conventional intensity-based models for conditional joint distribution, we also draw on flexible intensity-free TPP models from the literature. The proposed TPP models outperform conditionally independent and dependent models in standard prediction tasks. Our experimentation on various datasets with multiple evaluation metrics highlights the merit of the proposed approach.

  • 4 authors
·
Oct 27, 2022

Understanding the Effect of Noise in LLM Training Data with Algorithmic Chains of Thought

During both pretraining and fine-tuning, Large Language Models (LLMs) are trained on trillions of tokens of text of widely varying quality. Both phases of training typically involve heuristically filtering out ``low-quality'' or noisy training samples, yet little is known quantitatively about how the type or intensity of noise affects downstream performance. In this work, we study how noise in chain of thought (CoT) impacts task performance in the highly-controlled setting of algorithmically solvable tasks. First, we develop the Traced Integer (TInt) framework to generate highly customizable noised execution traces for any arithmetic function on lists of integers. We then define two types of noise: static noise, a local form of noise which is applied after the CoT trace is computed, and dynamic noise, a global form of noise which propagates errors in the trace as it is computed. We then evaluate the test performance of pretrained models both prompted and fine-tuned on noised datasets with varying levels of dataset contamination and intensity. We find fine-tuned models are extremely robust to high levels of static noise but struggle significantly more with lower levels of dynamic noise. In contrast, few-shot prompted models appear more sensitive to even static noise. We conclude with a discussion of how our findings impact noise filtering best-practices, in particular emphasizing the importance of removing samples containing destructive dynamic noise with global errors.

  • 2 authors
·
Feb 6, 2024

The Relationship Between Reasoning and Performance in Large Language Models -- o3 (mini) Thinks Harder, Not Longer

Large language models have demonstrated remarkable progress in mathematical reasoning, leveraging chain-of-thought and test-time compute scaling. However, many open questions remain regarding the interplay between reasoning token usage and accuracy gains. In particular, when comparing models across generations, it is unclear whether improved performance results from longer reasoning chains or more efficient reasoning. We systematically analyze chain-of-thought length across o1-mini and o3-mini variants on the Omni-MATH benchmark, finding that o3-mini (m) achieves superior accuracy without requiring longer reasoning chains than o1-mini. Moreover, we show that accuracy generally declines as reasoning chains grow across all models and compute settings, even when controlling for difficulty of the questions. This accuracy drop is significantly smaller in more proficient models, suggesting that new generations of reasoning models use test-time compute more effectively. Finally, we highlight that while o3-mini (h) achieves a marginal accuracy gain over o3-mini (m), it does so by allocating substantially more reasoning tokens across all problems, even the ones that o3-mini (m) can already solve. These findings provide new insights into the relationship between model capability and reasoning length, with implications for efficiency, scaling, and evaluation methodologies.

  • 3 authors
·
Feb 21, 2025 2

Long Grounded Thoughts: Distilling Compositional Visual Reasoning Chains at Scale

Recent progress in multimodal reasoning has been driven largely by undisclosed datasets and proprietary data synthesis recipes, leaving open questions about how to systematically build large-scale, vision-centric reasoning datasets, particularly for tasks that go beyond visual math. In this work, we introduce a new reasoning data generation framework spanning diverse skills and levels of complexity with over 1M high-quality synthetic vision-centric questions. The dataset also includes preference data and instruction prompts supporting both offline and online RL. Our synthesis framework proceeds in two stages: (1) scale; and (2) complexity. Reasoning traces are then synthesized through a two-stage process that leverages VLMs and reasoning LLMs, producing CoT traces for VLMs that capture the richness and diverse cognitive behaviors found in frontier reasoning models. Remarkably, we show that finetuning Qwen2.5-VL-7B on our data outperforms all open-data baselines across all evaluated vision-centric benchmarks, and even surpasses strong closed-data models such as MiMo-VL-7B-RL on V* Bench, CV-Bench and MMStar-V. Perhaps most surprising, despite being entirely vision-centric, our data transfers positively to text-only reasoning (MMLU-Pro) and audio reasoning (MMAU), demonstrating its effectiveness. Similarly, despite not containing videos or embodied visual data, we observe notable gains when evaluating on a single-evidence embodied QA benchmark (NiEH). Finally, we use our data to analyze the entire VLM post-training pipeline. Our empirical analysis highlights that (i) SFT on high-quality data with non-linear reasoning traces is essential for effective online RL, (ii) staged offline RL matches online RL's performance while reducing compute demands, and (iii) careful SFT on high quality data can substantially improve out-of-domain, cross-modality transfer.

nvidia NVIDIA
·
Nov 7, 2025 2

Teaching Transformers Causal Reasoning through Axiomatic Training

For text-based AI systems to interact in the real world, causal reasoning is an essential skill. Since interventional data is costly to generate, we study to what extent an agent can learn causal reasoning from passive data. Specifically, we consider an axiomatic training setup where an agent learns from multiple demonstrations of a causal axiom (or rule), rather than incorporating the axiom as an inductive bias or inferring it from data values. A key question is whether the agent would learn to generalize from the axiom demonstrations to new scenarios. For example, if a transformer model is trained on demonstrations of the causal transitivity axiom over small graphs, would it generalize to applying the transitivity axiom over large graphs? Our results, based on a novel axiomatic training scheme, indicate that such generalization is possible. We consider the task of inferring whether a variable causes another variable, given a causal graph structure. We find that a 67 million parameter transformer model, when trained on linear causal chains (along with some noisy variations) can generalize well to new kinds of graphs, including longer causal chains, causal chains with reversed order, and graphs with branching; even when it is not explicitly trained for such settings. Our model performs at par (or even better) than many larger language models such as GPT-4, Gemini Pro, and Phi-3. Overall, our axiomatic training framework provides a new paradigm of learning causal reasoning from passive data that can be used to learn arbitrary axioms, as long as sufficient demonstrations can be generated.

  • 5 authors
·
Jul 10, 2024

Knowledge Distillation Using Frontier Open-source LLMs: Generalizability and the Role of Synthetic Data

Leading open-source large language models (LLMs) such as Llama-3.1-Instruct-405B are extremely capable at generating text, answering questions, and solving a variety of natural language understanding tasks. However, they incur higher inference cost and latency compared to smaller LLMs. Knowledge distillation provides a way to use outputs from these large, capable teacher models to train smaller student models which can be used for inference at lower cost and latency, while retaining comparable accuracy. We investigate the efficacy of distillation using the Llama-3.1-405B-Instruct teacher and the smaller Llama-3.1-8B-Instruct and Llama-3.1-70B-Instruct student models. Contributions of this work include (a) We evaluate the generalizability of distillation with the above Llama-3.1 teacher-student pairs across different tasks and datasets (b) We show that using synthetic data during distillation significantly improves the accuracy of 8B and 70B models, and when used with reasoning chains, even matches or surpasses the zero-shot accuracy of 405B model on some datasets (c) We empirically show that distillation enables 8B and 70B models to internalize 405B's reasoning ability by using only standard fine-tuning (without customizing any loss function). This allows cost and latency-efficient student model inference. (d) We show pitfalls in evaluation of distillation, and present task-specific evaluation, including both human and LLM-grading, and ground-truth based traditional accuracy benchmarks. This methodical study brings out the fundamental importance of synthetic data quality in knowledge distillation, and of combining multiple, task-specific ways of accuracy and quality evaluation in assessing the effectiveness of distillation.

  • 5 authors
·
Oct 24, 2024

Foundation Inference Models for Markov Jump Processes

Markov jump processes are continuous-time stochastic processes which describe dynamical systems evolving in discrete state spaces. These processes find wide application in the natural sciences and machine learning, but their inference is known to be far from trivial. In this work we introduce a methodology for zero-shot inference of Markov jump processes (MJPs), on bounded state spaces, from noisy and sparse observations, which consists of two components. First, a broad probability distribution over families of MJPs, as well as over possible observation times and noise mechanisms, with which we simulate a synthetic dataset of hidden MJPs and their noisy observation process. Second, a neural network model that processes subsets of the simulated observations, and that is trained to output the initial condition and rate matrix of the target MJP in a supervised way. We empirically demonstrate that one and the same (pretrained) model can infer, in a zero-shot fashion, hidden MJPs evolving in state spaces of different dimensionalities. Specifically, we infer MJPs which describe (i) discrete flashing ratchet systems, which are a type of Brownian motors, and the conformational dynamics in (ii) molecular simulations, (iii) experimental ion channel data and (iv) simple protein folding models. What is more, we show that our model performs on par with state-of-the-art models which are finetuned to the target datasets.

  • 5 authors
·
Jun 10, 2024

TimeGraphs: Graph-based Temporal Reasoning

Many real-world systems exhibit temporal, dynamic behaviors, which are captured as time series of complex agent interactions. To perform temporal reasoning, current methods primarily encode temporal dynamics through simple sequence-based models. However, in general these models fail to efficiently capture the full spectrum of rich dynamics in the input, since the dynamics is not uniformly distributed. In particular, relevant information might be harder to extract and computing power is wasted for processing all individual timesteps, even if they contain no significant changes or no new information. Here we propose TimeGraphs, a novel approach that characterizes dynamic interactions as a hierarchical temporal graph, diverging from traditional sequential representations. Our approach models the interactions using a compact graph-based representation, enabling adaptive reasoning across diverse time scales. Adopting a self-supervised method, TimeGraphs constructs a multi-level event hierarchy from a temporal input, which is then used to efficiently reason about the unevenly distributed dynamics. This construction process is scalable and incremental to accommodate streaming data. We evaluate TimeGraphs on multiple datasets with complex, dynamic agent interactions, including a football simulator, the Resistance game, and the MOMA human activity dataset. The results demonstrate both robustness and efficiency of TimeGraphs on a range of temporal reasoning tasks. Our approach obtains state-of-the-art performance and leads to a performance increase of up to 12.2% on event prediction and recognition tasks over current approaches. Our experiments further demonstrate a wide array of capabilities including zero-shot generalization, robustness in case of data sparsity, and adaptability to streaming data flow.

  • 5 authors
·
Jan 6, 2024

Prompt-augmented Temporal Point Process for Streaming Event Sequence

Neural Temporal Point Processes (TPPs) are the prevalent paradigm for modeling continuous-time event sequences, such as user activities on the web and financial transactions. In real-world applications, event data is typically received in a streaming manner, where the distribution of patterns may shift over time. Additionally, privacy and memory constraints are commonly observed in practical scenarios, further compounding the challenges. Therefore, the continuous monitoring of a TPP to learn the streaming event sequence is an important yet under-explored problem. Our work paper addresses this challenge by adopting Continual Learning (CL), which makes the model capable of continuously learning a sequence of tasks without catastrophic forgetting under realistic constraints. Correspondingly, we propose a simple yet effective framework, PromptTPPOur code is available at {\small \url{ https://github.com/yanyanSann/PromptTPP}}, by integrating the base TPP with a continuous-time retrieval prompt pool. The prompts, small learnable parameters, are stored in a memory space and jointly optimized with the base TPP, ensuring that the model learns event streams sequentially without buffering past examples or task-specific attributes. We present a novel and realistic experimental setup for modeling event streams, where PromptTPP consistently achieves state-of-the-art performance across three real user behavior datasets.

  • 10 authors
·
Oct 7, 2023

Chain-of-Model Learning for Language Model

In this paper, we propose a novel learning paradigm, termed Chain-of-Model (CoM), which incorporates the causal relationship into the hidden states of each layer as a chain style, thereby introducing great scaling efficiency in model training and inference flexibility in deployment. We introduce the concept of Chain-of-Representation (CoR), which formulates the hidden states at each layer as a combination of multiple sub-representations (i.e., chains) at the hidden dimension level. In each layer, each chain from the output representations can only view all of its preceding chains in the input representations. Consequently, the model built upon CoM framework can progressively scale up the model size by increasing the chains based on the previous models (i.e., chains), and offer multiple sub-models at varying sizes for elastic inference by using different chain numbers. Based on this principle, we devise Chain-of-Language-Model (CoLM), which incorporates the idea of CoM into each layer of Transformer architecture. Based on CoLM, we further introduce CoLM-Air by introducing a KV sharing mechanism, that computes all keys and values within the first chain and then shares across all chains. This design demonstrates additional extensibility, such as enabling seamless LM switching, prefilling acceleration and so on. Experimental results demonstrate our CoLM family can achieve comparable performance to the standard Transformer, while simultaneously enabling greater flexiblity, such as progressive scaling to improve training efficiency and offer multiple varying model sizes for elastic inference, paving a a new way toward building language models. Our code will be released in the future at: https://github.com/microsoft/CoLM.

  • 17 authors
·
May 17, 2025 8

Self-Attentive Hawkes Processes

Asynchronous events on the continuous time domain, e.g., social media actions and stock transactions, occur frequently in the world. The ability to recognize occurrence patterns of event sequences is crucial to predict which typeof events will happen next and when. A de facto standard mathematical framework to do this is the Hawkes process. In order to enhance expressivity of multivariate Hawkes processes, conventional statistical methods and deep recurrent networks have been employed to modify its intensity function. The former is highly interpretable and requires small size of training data but relies on correct model design while the latter has less dependency on prior knowledge and is more powerful in capturing complicated patterns. We leverage pros and cons of these models and propose a self-attentive Hawkes process(SAHP). The proposed method adapts self-attention to fit the intensity function of Hawkes processes. This design has two benefits:(1) compared with conventional statistical methods, the SAHP is more powerful to identify complicated dependency relationships between temporal events; (2)compared with deep recurrent networks, the self-attention mechanism is able to capture longer historical information, and is more interpretable because the learnt attention weight tensor shows contributions of each historical event. Experiments on four real-world datasets demonstrate the effectiveness of the proposed method.

  • 4 authors
·
Jul 17, 2019

Servant, Stalker, Predator: How An Honest, Helpful, And Harmless (3H) Agent Unlocks Adversarial Skills

This paper identifies and analyzes a novel vulnerability class in Model Context Protocol (MCP) based agent systems. The attack chain describes and demonstrates how benign, individually authorized tasks can be orchestrated to produce harmful emergent behaviors. Through systematic analysis using the MITRE ATLAS framework, we demonstrate how 95 agents tested with access to multiple services-including browser automation, financial analysis, location tracking, and code deployment-can chain legitimate operations into sophisticated attack sequences that extend beyond the security boundaries of any individual service. These red team exercises survey whether current MCP architectures lack cross-domain security measures necessary to detect or prevent a large category of compositional attacks. We present empirical evidence of specific attack chains that achieve targeted harm through service orchestration, including data exfiltration, financial manipulation, and infrastructure compromise. These findings reveal that the fundamental security assumption of service isolation fails when agents can coordinate actions across multiple domains, creating an exponential attack surface that grows with each additional capability. This research provides a barebones experimental framework that evaluate not whether agents can complete MCP benchmark tasks, but what happens when they complete them too well and optimize across multiple services in ways that violate human expectations and safety constraints. We propose three concrete experimental directions using the existing MCP benchmark suite.

  • 1 authors
·
Aug 26, 2025 2

How to Train Your HiPPO: State Space Models with Generalized Orthogonal Basis Projections

Linear time-invariant state space models (SSM) are a classical model from engineering and statistics, that have recently been shown to be very promising in machine learning through the Structured State Space sequence model (S4). A core component of S4 involves initializing the SSM state matrix to a particular matrix called a HiPPO matrix, which was empirically important for S4's ability to handle long sequences. However, the specific matrix that S4 uses was actually derived in previous work for a particular time-varying dynamical system, and the use of this matrix as a time-invariant SSM had no known mathematical interpretation. Consequently, the theoretical mechanism by which S4 models long-range dependencies actually remains unexplained. We derive a more general and intuitive formulation of the HiPPO framework, which provides a simple mathematical interpretation of S4 as a decomposition onto exponentially-warped Legendre polynomials, explaining its ability to capture long dependencies. Our generalization introduces a theoretically rich class of SSMs that also lets us derive more intuitive S4 variants for other bases such as the Fourier basis, and explains other aspects of training S4, such as how to initialize the important timescale parameter. These insights improve S4's performance to 86% on the Long Range Arena benchmark, with 96% on the most difficult Path-X task.

  • 5 authors
·
Jun 23, 2022

A Benchmark Time Series Dataset for Semiconductor Fabrication Manufacturing Constructed using Component-based Discrete-Event Simulation Models

Advancements in high-computing devices increase the necessity for improved and new understanding and development of smart manufacturing factories. Discrete-event models with simulators have been shown to be critical to architect, designing, building, and operating the manufacturing of semiconductor chips. The diffusion, implantation, and lithography machines have intricate processes due to their feedforward and feedback connectivity. The dataset collected from simulations of the factory models holds the promise of generating valuable machine-learning models. As surrogate data-based models, their executions are highly efficient compared to the physics-based counterpart models. For the development of surrogate models, it is beneficial to have publicly available benchmark simulation models that are grounded in factory models that have concise structures and accurate behaviors. Hence, in this research, a dataset is devised and constructed based on a benchmark model of an Intel semiconductor fabrication factory. The model is formalized using the Parallel Discrete-Event System Specification and executed using the DEVS-Suite simulator. The time series dataset is constructed using discrete-event time trajectories. This dataset is further analyzed and used to develop baseline univariate and multivariate machine learning models. The dataset can also be utilized in the machine learning community for behavioral analysis based on formalized and scalable component-based discrete-event models and simulations.

  • 4 authors
·
Aug 17, 2024

EvRT-DETR: Latent Space Adaptation of Image Detectors for Event-based Vision

Event-based cameras (EBCs) have emerged as a bio-inspired alternative to traditional cameras, offering advantages in power efficiency, temporal resolution, and high dynamic range. However, the development of image analysis methods for EBCs is challenging due to the sparse and asynchronous nature of the data. This work addresses the problem of object detection for EBC cameras. The current approaches to EBC object detection focus on constructing complex data representations and rely on specialized architectures. We introduce I2EvDet (Image-to-Event Detection), a novel adaptation framework that bridges mainstream object detection with temporal event data processing. First, we demonstrate that a Real-Time DEtection TRansformer, or RT-DETR, a state-of-the-art natural image detector, trained on a simple image-like representation of the EBC data achieves performance comparable to specialized EBC methods. Next, as part of our framework, we develop an efficient adaptation technique that transforms image-based detectors into event-based detection models by modifying their frozen latent representation space through minimal architectural additions. The resulting EvRT-DETR model reaches state-of-the-art performance on the standard benchmark datasets Gen1 (mAP +2.3) and 1Mpx/Gen4 (mAP +1.4). These results demonstrate a fundamentally new approach to EBC object detection through principled adaptation of mainstream architectures, offering an efficient alternative with potential applications to other temporal visual domains. The code is available at: https://github.com/realtime-intelligence/evrt-detr

  • 5 authors
·
Dec 3, 2024

CodeChain: Towards Modular Code Generation Through Chain of Self-revisions with Representative Sub-modules

Large Language Models (LLMs) have already become quite proficient at solving simpler programming tasks like those in HumanEval or MBPP benchmarks. However, solving more complex and competitive programming tasks is still quite challenging for these models - possibly due to their tendency to generate solutions as monolithic code blocks instead of decomposing them into logical sub-tasks and sub-modules. On the other hand, experienced programmers instinctively write modularized code with abstraction for solving complex tasks, often reusing previously developed modules. To address this gap, we propose CodeChain, a novel framework for inference that elicits modularized code generation through a chain of self-revisions, each being guided by some representative sub-modules generated in previous iterations. Concretely, CodeChain first instructs the LLM to generate modularized codes through chain-of-thought prompting. Then it applies a chain of self-revisions by iterating the two steps: 1) extracting and clustering the generated sub-modules and selecting the cluster representatives as the more generic and re-usable implementations, and 2) augmenting the original chain-of-thought prompt with these selected module-implementations and instructing the LLM to re-generate new modularized solutions. We find that by naturally encouraging the LLM to reuse the previously developed and verified sub-modules, CodeChain can significantly boost both modularity as well as correctness of the generated solutions, achieving relative pass@1 improvements of 35% on APPS and 76% on CodeContests. It is shown to be effective on both OpenAI LLMs as well as open-sourced LLMs like WizardCoder. We also conduct comprehensive ablation studies with different methods of prompting, number of clusters, model sizes, program qualities, etc., to provide useful insights that underpin CodeChain's success.

  • 6 authors
·
Oct 13, 2023 1

eKalibr: Dynamic Intrinsic Calibration for Event Cameras From First Principles of Events

The bio-inspired event camera has garnered extensive research attention in recent years, owing to its significant potential derived from its high dynamic range and low latency characteristics. Similar to the standard camera, the event camera requires precise intrinsic calibration to facilitate further high-level visual applications, such as pose estimation and mapping. While several calibration methods for event cameras have been proposed, most of them are either (i) engineering-driven, heavily relying on conventional image-based calibration pipelines, or (ii) inconvenient, requiring complex instrumentation. To this end, we propose an accurate and convenient intrinsic calibration method for event cameras, named eKalibr, which builds upon a carefully designed event-based circle grid pattern recognition algorithm. To extract target patterns from events, we perform event-based normal flow estimation to identify potential events generated by circle edges, and cluster them spatially. Subsequently, event clusters associated with the same grid circles are matched and grouped using normal flows, for subsequent time-varying ellipse estimation. Fitted ellipse centers are time-synchronized, for final grid pattern recognition. We conducted extensive experiments to evaluate the performance of eKalibr in terms of pattern extraction and intrinsic calibration. The implementation of eKalibr is open-sourced at (https://github.com/Unsigned-Long/eKalibr) to benefit the research community.

  • 4 authors
·
Jan 9, 2025

Piecewise-Velocity Model for Learning Continuous-time Dynamic Node Representations

Networks have become indispensable and ubiquitous structures in many fields to model the interactions among different entities, such as friendship in social networks or protein interactions in biological graphs. A major challenge is to understand the structure and dynamics of these systems. Although networks evolve through time, most existing graph representation learning methods target only static networks. Whereas approaches have been developed for the modeling of dynamic networks, there is a lack of efficient continuous time dynamic graph representation learning methods that can provide accurate network characterization and visualization in low dimensions while explicitly accounting for prominent network characteristics such as homophily and transitivity. In this paper, we propose the Piecewise-Velocity Model (PiVeM) for the representation of continuous-time dynamic networks. It learns dynamic embeddings in which the temporal evolution of nodes is approximated by piecewise linear interpolations based on a latent distance model with piecewise constant node-specific velocities. The model allows for analytically tractable expressions of the associated Poisson process likelihood with scalable inference invariant to the number of events. We further impose a scalable Kronecker structured Gaussian Process prior to the dynamics accounting for community structure, temporal smoothness, and disentangled (uncorrelated) latent embedding dimensions optimally learned to characterize the network dynamics. We show that PiVeM can successfully represent network structure and dynamics in ultra-low two-dimensional spaces. It outperforms relevant state-of-art methods in downstream tasks such as link prediction. In summary, PiVeM enables easily interpretable dynamic network visualizations and characterizations that can further improve our understanding of the intrinsic dynamics of time-evolving networks.

  • 3 authors
·
Dec 23, 2022

A 5-Point Minimal Solver for Event Camera Relative Motion Estimation

Event-based cameras are ideal for line-based motion estimation, since they predominantly respond to edges in the scene. However, accurately determining the camera displacement based on events continues to be an open problem. This is because line feature extraction and dynamics estimation are tightly coupled when using event cameras, and no precise model is currently available for describing the complex structures generated by lines in the space-time volume of events. We solve this problem by deriving the correct non-linear parametrization of such manifolds, which we term eventails, and demonstrate its application to event-based linear motion estimation, with known rotation from an Inertial Measurement Unit. Using this parametrization, we introduce a novel minimal 5-point solver that jointly estimates line parameters and linear camera velocity projections, which can be fused into a single, averaged linear velocity when considering multiple lines. We demonstrate on both synthetic and real data that our solver generates more stable relative motion estimates than other methods while capturing more inliers than clustering based on spatio-temporal planes. In particular, our method consistently achieves a 100% success rate in estimating linear velocity where existing closed-form solvers only achieve between 23% and 70%. The proposed eventails contribute to a better understanding of spatio-temporal event-generated geometries and we thus believe it will become a core building block of future event-based motion estimation algorithms.

  • 6 authors
·
Sep 29, 2023

An Interdisciplinary Comparison of Sequence Modeling Methods for Next-Element Prediction

Data of sequential nature arise in many application domains in forms of, e.g. textual data, DNA sequences, and software execution traces. Different research disciplines have developed methods to learn sequence models from such datasets: (i) in the machine learning field methods such as (hidden) Markov models and recurrent neural networks have been developed and successfully applied to a wide-range of tasks, (ii) in process mining process discovery techniques aim to generate human-interpretable descriptive models, and (iii) in the grammar inference field the focus is on finding descriptive models in the form of formal grammars. Despite their different focuses, these fields share a common goal - learning a model that accurately describes the behavior in the underlying data. Those sequence models are generative, i.e, they can predict what elements are likely to occur after a given unfinished sequence. So far, these fields have developed mainly in isolation from each other and no comparison exists. This paper presents an interdisciplinary experimental evaluation that compares sequence modeling techniques on the task of next-element prediction on four real-life sequence datasets. The results indicate that machine learning techniques that generally have no aim at interpretability in terms of accuracy outperform techniques from the process mining and grammar inference fields that aim to yield interpretable models.

  • 3 authors
·
Oct 31, 2018

Entity Embedding-based Anomaly Detection for Heterogeneous Categorical Events

Anomaly detection plays an important role in modern data-driven security applications, such as detecting suspicious access to a socket from a process. In many cases, such events can be described as a collection of categorical values that are considered as entities of different types, which we call heterogeneous categorical events. Due to the lack of intrinsic distance measures among entities, and the exponentially large event space, most existing work relies heavily on heuristics to calculate abnormal scores for events. Different from previous work, we propose a principled and unified probabilistic model APE (Anomaly detection via Probabilistic pairwise interaction and Entity embedding) that directly models the likelihood of events. In this model, we embed entities into a common latent space using their observed co-occurrence in different events. More specifically, we first model the compatibility of each pair of entities according to their embeddings. Then we utilize the weighted pairwise interactions of different entity types to define the event probability. Using Noise-Contrastive Estimation with "context-dependent" noise distribution, our model can be learned efficiently regardless of the large event space. Experimental results on real enterprise surveillance data show that our methods can accurately detect abnormal events compared to other state-of-the-art abnormal detection techniques.

  • 5 authors
·
Aug 26, 2016

Understanding Chain-of-Thought in Large Language Models via Topological Data Analysis

With the development of large language models (LLMs), particularly with the introduction of the long reasoning chain technique, the reasoning ability of LLMs in complex problem-solving has been significantly enhanced. While acknowledging the power of long reasoning chains, we cannot help but wonder: Why do different reasoning chains perform differently in reasoning? What components of the reasoning chains play a key role? Existing studies mainly focus on evaluating reasoning chains from a functional perspective, with little attention paid to their structural mechanisms. To address this gap, this work is the first to analyze and evaluate the quality of the reasoning chain from a structural perspective. We apply persistent homology from Topological Data Analysis (TDA) to map reasoning steps into semantic space, extract topological features, and analyze structural changes. These changes reveal semantic coherence, logical redundancy, and identify logical breaks and gaps. By calculating homology groups, we assess connectivity and redundancy at various scales, using barcode and persistence diagrams to quantify stability and consistency. Our results show that the topological structural complexity of reasoning chains correlates positively with accuracy. More complex chains identify correct answers sooner, while successful reasoning exhibits simpler topologies, reducing redundancy and cycles, enhancing efficiency and interpretability. This work provides a new perspective on reasoning chain quality assessment and offers guidance for future optimization.

  • 13 authors
·
Dec 22, 2025

Robust e-NeRF: NeRF from Sparse & Noisy Events under Non-Uniform Motion

Event cameras offer many advantages over standard cameras due to their distinctive principle of operation: low power, low latency, high temporal resolution and high dynamic range. Nonetheless, the success of many downstream visual applications also hinges on an efficient and effective scene representation, where Neural Radiance Field (NeRF) is seen as the leading candidate. Such promise and potential of event cameras and NeRF inspired recent works to investigate on the reconstruction of NeRF from moving event cameras. However, these works are mainly limited in terms of the dependence on dense and low-noise event streams, as well as generalization to arbitrary contrast threshold values and camera speed profiles. In this work, we propose Robust e-NeRF, a novel method to directly and robustly reconstruct NeRFs from moving event cameras under various real-world conditions, especially from sparse and noisy events generated under non-uniform motion. It consists of two key components: a realistic event generation model that accounts for various intrinsic parameters (e.g. time-independent, asymmetric threshold and refractory period) and non-idealities (e.g. pixel-to-pixel threshold variation), as well as a complementary pair of normalized reconstruction losses that can effectively generalize to arbitrary speed profiles and intrinsic parameter values without such prior knowledge. Experiments on real and novel realistically simulated sequences verify our effectiveness. Our code, synthetic dataset and improved event simulator are public.

  • 2 authors
·
Sep 15, 2023

Chain-of-Agents: End-to-End Agent Foundation Models via Multi-Agent Distillation and Agentic RL

Recent advances in large language models (LLMs) and multi-agent systems have demonstrated remarkable capabilities in complex problem-solving tasks such as deep research, vibe coding, and mathematical reasoning. However, most existing multi-agent systems are built upon manual prompt/workflow engineering with sophisticated agent frameworks, making them computationally inefficient, less capable, and can not benefit from data-centric learning. In this work, we introduce Chain-of-Agents (CoA), a novel paradigm of LLM reasoning that enables native end-to-end complex problem-solving in the same way as a multi-agent system (i.e., multi-turn problem solving with multiple tools and multiple agents) within one model. In chain-of-agents problem-solving, the model dynamically activates different tool agents and role-playing agents to simulate multi-agent collaboration in an end-to-end fashion. To elicit end-to-end chain-of-agents problem-solving abilities in LLMs, we introduce a multi-agent distillation framework to distill state-of-the-art multi-agent systems into chain-of-agents trajectories for agentic supervised fine-tuning. We then use agentic reinforcement learning on verifiable agentic tasks to further improve the models' capabilities on chain-of-agents problem solving. We call the resulting models Agent Foundation Models (AFMs). Our empirical studies demonstrate that AFM establishes new state-of-the-art performance across diverse benchmarks in both web agent and code agent settings. We make the entire research, including the model weights, code for training and evaluation, and the training data, fully open-sourced, which offers a solid starting point for future research on agent models and agentic RL.

  • 30 authors
·
Aug 6, 2025 8

Learning heterogeneous delays in a layer of spiking neurons for fast motion detection

The precise timing of spikes emitted by neurons plays a crucial role in shaping the response of efferent biological neurons. This temporal dimension of neural activity holds significant importance in understanding information processing in neurobiology, especially for the performance of neuromorphic hardware, such as event-based cameras. Nonetheless, many artificial neural models disregard this critical temporal dimension of neural activity. In this study, we present a model designed to efficiently detect temporal spiking motifs using a layer of spiking neurons equipped with heterogeneous synaptic delays. Our model capitalizes on the diverse synaptic delays present on the dendritic tree, enabling specific arrangements of temporally precise synaptic inputs to synchronize upon reaching the basal dendritic tree. We formalize this process as a time-invariant logistic regression, which can be trained using labeled data. To demonstrate its practical efficacy, we apply the model to naturalistic videos transformed into event streams, simulating the output of the biological retina or event-based cameras. To evaluate the robustness of the model in detecting visual motion, we conduct experiments by selectively pruning weights and demonstrate that the model remains efficient even under significantly reduced workloads. In conclusion, by providing a comprehensive, event-driven computational building block, the incorporation of heterogeneous delays has the potential to greatly improve the performance of future spiking neural network algorithms, particularly in the context of neuromorphic chips.

  • 2 authors
·
Jul 26, 2023

Simplicial Closure and higher-order link prediction

Networks provide a powerful formalism for modeling complex systems by using a model of pairwise interactions. But much of the structure within these systems involves interactions that take place among more than two nodes at once; for example, communication within a group rather than person-to person, collaboration among a team rather than a pair of coauthors, or biological interaction between a set of molecules rather than just two. Such higher-order interactions are ubiquitous, but their empirical study has received limited attention, and little is known about possible organizational principles of such structures. Here we study the temporal evolution of 19 datasets with explicit accounting for higher-order interactions. We show that there is a rich variety of structure in our datasets but datasets from the same system types have consistent patterns of higher-order structure. Furthermore, we find that tie strength and edge density are competing positive indicators of higher-order organization, and these trends are consistent across interactions involving differing numbers of nodes. To systematically further the study of theories for such higher-order structures, we propose higher-order link prediction as a benchmark problem to assess models and algorithms that predict higher-order structure. We find a fundamental differences from traditional pairwise link prediction, with a greater role for local rather than long-range information in predicting the appearance of new interactions.

  • 5 authors
·
Feb 19, 2018

Are Large Language Models Temporally Grounded?

Are Large language models (LLMs) temporally grounded? Since LLMs cannot perceive and interact with the environment, it is impossible to answer this question directly. Instead, we provide LLMs with textual narratives and probe them with respect to their common-sense knowledge of the structure and duration of events, their ability to order events along a timeline, and self-consistency within their temporal model (e.g., temporal relations such as after and before are mutually exclusive for any pair of events). We evaluate state-of-the-art LLMs (such as LLaMA 2 and GPT-4) on three tasks reflecting these abilities. Generally, we find that LLMs lag significantly behind both human performance as well as small-scale, specialised LMs. In-context learning, instruction tuning, and chain-of-thought prompting reduce this gap only to a limited degree. Crucially, LLMs struggle the most with self-consistency, displaying incoherent behaviour in at least 27.23% of their predictions. Contrary to expectations, we also find that scaling the model size does not guarantee positive gains in performance. To explain these results, we study the sources from which LLMs may gather temporal information: we find that sentence ordering in unlabelled texts, available during pre-training, is only weakly correlated with event ordering. Moreover, public instruction tuning mixtures contain few temporal tasks. Hence, we conclude that current LLMs lack a consistent temporal model of textual narratives. Code, datasets, and LLM outputs are available at https://github.com/yfqiu-nlp/temporal-llms.

  • 6 authors
·
Nov 14, 2023

From Graphs to Hypergraphs: Hypergraph Projection and its Remediation

We study the implications of the modeling choice to use a graph, instead of a hypergraph, to represent real-world interconnected systems whose constituent relationships are of higher order by nature. Such a modeling choice typically involves an underlying projection process that maps the original hypergraph onto a graph, and is common in graph-based analysis. While hypergraph projection can potentially lead to loss of higher-order relations, there exists very limited studies on the consequences of doing so, as well as its remediation. This work fills this gap by doing two things: (1) we develop analysis based on graph and set theory, showing two ubiquitous patterns of hyperedges that are root to structural information loss in all hypergraph projections; we also quantify the combinatorial impossibility of recovering the lost higher-order structures if no extra help is provided; (2) we still seek to recover the lost higher-order structures in hypergraph projection, and in light of (1)'s findings we propose to relax the problem into a learning-based setting. Under this setting, we develop a learning-based hypergraph reconstruction method based on an important statistic of hyperedge distributions that we find. Our reconstruction method is evaluated on 8 real-world datasets under different settings, and exhibits consistently good performance. We also demonstrate benefits of the reconstructed hypergraphs via use cases of protein rankings and link predictions.

  • 2 authors
·
Jan 16, 2024

Causal de Finetti: On the Identification of Invariant Causal Structure in Exchangeable Data

Learning causal structure from observational data often assumes that we observe independent and identically distributed (i.\,i.\,d) data. The traditional approach aims to find a graphical representation that encodes the same set of conditional independence relationships as those present in the observed distribution. It is known that under i.\,i.\,d assumption, even with infinite data, there is a limit to how fine-grained a causal structure we can identify. To overcome this limitation, recent work has explored using data originating from different, related environments to learn richer causal structure. These approaches implicitly rely on the independent causal mechanisms (ICM) principle, which postulates that the mechanism giving rise to an effect given its causes and the mechanism which generates the causes do not inform or influence each other. Thus, components of the causal model can independently change from environment to environment. Despite its wide application in machine learning and causal inference, there is a lack of statistical formalization of the ICM principle and how it enables identification of richer causal structures from grouped data. Here we present new causal de Finetti theorems which offer a first statistical formalization of ICM principle and show how causal structure identification is possible from exchangeable data. Our work provides theoretical justification for a broad range of techniques leveraging multi-environment data to learn causal structure.

  • 4 authors
·
Mar 29, 2022

Event Knowledge Incorporation with Posterior Regularization for Event-Centric Question Answering

We propose a simple yet effective strategy to incorporate event knowledge extracted from event trigger annotations via posterior regularization to improve the event reasoning capability of mainstream question-answering (QA) models for event-centric QA. In particular, we define event-related knowledge constraints based on the event trigger annotations in the QA datasets, and subsequently use them to regularize the posterior answer output probabilities from the backbone pre-trained language models used in the QA setting. We explore two different posterior regularization strategies for extractive and generative QA separately. For extractive QA, the sentence-level event knowledge constraint is defined by assessing if a sentence contains an answer event or not, which is later used to modify the answer span extraction probability. For generative QA, the token-level event knowledge constraint is defined by comparing the generated token from the backbone language model with the answer event in order to introduce a reward or penalty term, which essentially adjusts the answer generative probability indirectly. We conduct experiments on two event-centric QA datasets, TORQUE and ESTER. The results show that our proposed approach can effectively inject event knowledge into existing pre-trained language models and achieves strong performance compared to existing QA models in answer evaluation. Code and models can be found: https://github.com/LuJunru/EventQAviaPR.

  • 4 authors
·
May 8, 2023

MAVEN-Arg: Completing the Puzzle of All-in-One Event Understanding Dataset with Event Argument Annotation

Understanding events in texts is a core objective of natural language understanding, which requires detecting event occurrences, extracting event arguments, and analyzing inter-event relationships. However, due to the annotation challenges brought by task complexity, a large-scale dataset covering the full process of event understanding has long been absent. In this paper, we introduce MAVEN-Arg, which augments MAVEN datasets with event argument annotations, making the first all-in-one dataset supporting event detection, event argument extraction (EAE), and event relation extraction. As an EAE benchmark, MAVEN-Arg offers three main advantages: (1) a comprehensive schema covering 162 event types and 612 argument roles, all with expert-written definitions and examples; (2) a large data scale, containing 98,591 events and 290,613 arguments obtained with laborious human annotation; (3) the exhaustive annotation supporting all task variants of EAE, which annotates both entity and non-entity event arguments in document level. Experiments indicate that MAVEN-Arg is quite challenging for both fine-tuned EAE models and proprietary large language models (LLMs). Furthermore, to demonstrate the benefits of an all-in-one dataset, we preliminarily explore a potential application, future event prediction, with LLMs. MAVEN-Arg and our code can be obtained from https://github.com/THU-KEG/MAVEN-Argument.

  • 12 authors
·
Nov 15, 2023

One Life to Learn: Inferring Symbolic World Models for Stochastic Environments from Unguided Exploration

Symbolic world modeling requires inferring and representing an environment's transitional dynamics as an executable program. Prior work has focused on largely deterministic environments with abundant interaction data, simple mechanics, and human guidance. We address a more realistic and challenging setting, learning in a complex, stochastic environment where the agent has only "one life" to explore a hostile environment without human guidance. We introduce OneLife, a framework that models world dynamics through conditionally-activated programmatic laws within a probabilistic programming framework. Each law operates through a precondition-effect structure, activating in relevant world states. This creates a dynamic computation graph that routes inference and optimization only through relevant laws, avoiding scaling challenges when all laws contribute to predictions about a complex, hierarchical state, and enabling the learning of stochastic dynamics even with sparse rule activation. To evaluate our approach under these demanding constraints, we introduce a new evaluation protocol that measures (a) state ranking, the ability to distinguish plausible future states from implausible ones, and (b) state fidelity, the ability to generate future states that closely resemble reality. We develop and evaluate our framework on Crafter-OO, our reimplementation of the Crafter environment that exposes a structured, object-oriented symbolic state and a pure transition function that operates on that state alone. OneLife can successfully learn key environment dynamics from minimal, unguided interaction, outperforming a strong baseline on 16 out of 23 scenarios tested. We also test OneLife's planning ability, with simulated rollouts successfully identifying superior strategies. Our work establishes a foundation for autonomously constructing programmatic world models of unknown, complex environments.

  • 5 authors
·
Oct 13, 2025 2

Continuous Locomotive Crowd Behavior Generation

Modeling and reproducing crowd behaviors are important in various domains including psychology, robotics, transport engineering and virtual environments. Conventional methods have focused on synthesizing momentary scenes, which have difficulty in replicating the continuous nature of real-world crowds. In this paper, we introduce a novel method for automatically generating continuous, realistic crowd trajectories with heterogeneous behaviors and interactions among individuals. We first design a crowd emitter model. To do this, we obtain spatial layouts from single input images, including a segmentation map, appearance map, population density map and population probability, prior to crowd generation. The emitter then continually places individuals on the timeline by assigning independent behavior characteristics such as agents' type, pace, and start/end positions using diffusion models. Next, our crowd simulator produces their long-term locomotions. To simulate diverse actions, it can augment their behaviors based on a Markov chain. As a result, our overall framework populates the scenes with heterogeneous crowd behaviors by alternating between the proposed emitter and simulator. Note that all the components in the proposed framework are user-controllable. Lastly, we propose a benchmark protocol to evaluate the realism and quality of the generated crowds in terms of the scene-level population dynamics and the individual-level trajectory accuracy. We demonstrate that our approach effectively models diverse crowd behavior patterns and generalizes well across different geographical environments. Code is publicly available at https://github.com/InhwanBae/CrowdES .

  • 3 authors
·
Apr 7, 2025 1

Language Modeling on a SpiNNaker 2 Neuromorphic Chip

As large language models continue to scale in size rapidly, so too does the computational power required to run them. Event-based networks on neuromorphic devices offer a potential way to reduce energy consumption for inference significantly. However, to date, most event-based networks that can run on neuromorphic hardware, including spiking neural networks (SNNs), have not achieved task performance even on par with LSTM models for language modeling. As a result, language modeling on neuromorphic devices has seemed a distant prospect. In this work, we demonstrate the first-ever implementation of a language model on a neuromorphic device - specifically the SpiNNaker 2 chip - based on a recently published event-based architecture called the EGRU. SpiNNaker 2 is a many-core neuromorphic chip designed for large-scale asynchronous processing, while the EGRU is architected to leverage such hardware efficiently while maintaining competitive task performance. This implementation marks the first time a neuromorphic language model matches LSTMs, setting the stage for taking task performance to the level of large language models. We also demonstrate results on a gesture recognition task based on inputs from a DVS camera. Overall, our results showcase the feasibility of this neuro-inspired neural network in hardware, highlighting significant gains versus conventional hardware in energy efficiency for the common use case of single batch inference.

  • 7 authors
·
Dec 14, 2023

Chimera: Effectively Modeling Multivariate Time Series with 2-Dimensional State Space Models

Modeling multivariate time series is a well-established problem with a wide range of applications from healthcare to financial markets. Traditional State Space Models (SSMs) are classical approaches for univariate time series modeling due to their simplicity and expressive power to represent linear dependencies. They, however, have fundamentally limited expressive power to capture non-linear dependencies, are slow in practice, and fail to model the inter-variate information flow. Despite recent attempts to improve the expressive power of SSMs by using deep structured SSMs, the existing methods are either limited to univariate time series, fail to model complex patterns (e.g., seasonal patterns), fail to dynamically model the dependencies of variate and time dimensions, and/or are input-independent. We present Chimera that uses two input-dependent 2-D SSM heads with different discretization processes to learn long-term progression and seasonal patterns. To improve the efficiency of complex 2D recurrence, we present a fast training using a new 2-dimensional parallel selective scan. We further present and discuss 2-dimensional Mamba and Mamba-2 as the spacial cases of our 2D SSM. Our experimental evaluation shows the superior performance of Chimera on extensive and diverse benchmarks, including ECG and speech time series classification, long-term and short-term time series forecasting, and time series anomaly detection.

  • 3 authors
·
Jun 6, 2024 1

Meta Flow Matching: Integrating Vector Fields on the Wasserstein Manifold

Numerous biological and physical processes can be modeled as systems of interacting entities evolving continuously over time, e.g. the dynamics of communicating cells or physical particles. Learning the dynamics of such systems is essential for predicting the temporal evolution of populations across novel samples and unseen environments. Flow-based models allow for learning these dynamics at the population level - they model the evolution of the entire distribution of samples. However, current flow-based models are limited to a single initial population and a set of predefined conditions which describe different dynamics. We argue that multiple processes in natural sciences have to be represented as vector fields on the Wasserstein manifold of probability densities. That is, the change of the population at any moment in time depends on the population itself due to the interactions between samples. In particular, this is crucial for personalized medicine where the development of diseases and their respective treatment response depends on the microenvironment of cells specific to each patient. We propose Meta Flow Matching (MFM), a practical approach to integrating along these vector fields on the Wasserstein manifold by amortizing the flow model over the initial populations. Namely, we embed the population of samples using a Graph Neural Network (GNN) and use these embeddings to train a Flow Matching model. This gives MFM the ability to generalize over the initial distributions unlike previously proposed methods. We demonstrate the ability of MFM to improve prediction of individual treatment responses on a large scale multi-patient single-cell drug screen dataset.

  • 8 authors
·
Aug 26, 2024 2