Daily Papers

Remaining Useful Life (RUL) prediction is essential for industrial predictive maintenance, yet many learning-based approaches rely on extensive feature engineering or large labeled datasets to train task-specific sequence models. In this work, we introduce a lightweight learning approach, in which we leverage a frozen pretrained time-series foundation model (TSFM) and combine it with a small regression head for RUL estimation from multivariate sensor streams. More specifically, we use Chronos-2 as a frozen backbone to extract context window features and train a lightweight regression neural network for RUL prediction. Experiments on real-world industrial sensor data from two device types show that Chronos-2 features consistently improve over recurrent, convolutional, Transformer-based, and gradient-boosting baselines under the same preprocessing and evaluation protocol. We further analyze the impact of context length and find that performance improves significantly with longer histories, indicating that TSFM representation offer a practical and data-efficient alternative for RUL estimation in industrial settings.

Time series anomaly detection forms a very crucial area in several domains but poses substantial challenges. Due to time series data possessing seasonality, trends, noise, and evolving patterns (concept drift), it becomes very difficult to set a general notion of what constitutes normal behavior. Anomalies themselves could be varied, ranging from a single outlier to contextual or collective anomalies, and are normally very rare; hence, the dataset is largely imbalanced. Additional layers of complexities arise due to the problems of increased dimensionality of modern time series, real-time detection criteria, setting up appropriate detection thresholds, and arriving at results that are interpretable. To embrace these multifaceted challenges, very strong, flexible, and interpretable approaches are required. This paper presents THEMIS, a new framework for time series anomaly detection that exploits pretrained knowledge from foundation models. THEMIS extracts embeddings from the encoder of the Chronos time series foundation model and applies outlier detection techniques like Local Outlier Factor and Spectral Decomposition on the self-similarity matrix, to spot anomalies in the data. Our experiments show that this modular method achieves SOTA results on the MSL dataset and performs quite competitively on the SMAP and SWAT^* datasets. Notably, THEMIS exceeds models trained specifically for anomaly detection, presenting hyperparameter robustness and interpretability by default. This paper advocates for pretrained representations from foundation models for performing efficient and adaptable anomaly detection for time series data.

DNA foundation models have become transformative tools in bioinformatics and healthcare applications. Trained on vast genomic datasets, these models can be used to generate sequence embeddings, dense vector representations that capture complex genomic information. These embeddings are increasingly being shared via Embeddings-as-a-Service (EaaS) frameworks to facilitate downstream tasks, while supposedly protecting the privacy of the underlying raw sequences. However, as this practice becomes more prevalent, the security of these representations is being called into question. This study evaluates the resilience of DNA foundation models to model inversion attacks, whereby adversaries attempt to reconstruct sensitive training data from model outputs. In our study, the model's output for reconstructing the DNA sequence is a zero-shot embedding, which is then fed to a decoder. We evaluated the privacy of three DNA foundation models: DNABERT-2, Evo 2, and Nucleotide Transformer v2 (NTv2). Our results show that per-token embeddings allow near-perfect sequence reconstruction across all models. For mean-pooled embeddings, reconstruction quality degrades as sequence length increases, though it remains substantially above random baselines. Evo 2 and NTv2 prove to be most vulnerable, especially for shorter sequences with reconstruction similarities > 90%, while DNABERT-2's BPE tokenization provides the greatest resilience. We found that the correlation between embedding similarity and sequence similarity was a key predictor of reconstruction success. Our findings emphasize the urgent need for privacy-aware design in genomic foundation models prior to their widespread deployment in EaaS settings. Training code, model weights and evaluation pipeline are released on: https://github.com/not-a-feature/DNA-Embedding-Inversion.

Face recognition systems extract embedding vectors from face images and use these embeddings to verify or identify individuals. Face reconstruction attack (also known as template inversion) refers to reconstructing face images from face embeddings and using the reconstructed face image to enter a face recognition system. In this paper, we propose to use a face foundation model to reconstruct face images from the embeddings of a blackbox face recognition model. The foundation model is trained with 42M images to generate face images from the facial embeddings of a fixed face recognition model. We propose to use an adapter to translate target embeddings into the embedding space of the foundation model. The generated images are evaluated on different face recognition models and different datasets, demonstrating the effectiveness of our method to translate embeddings of different face recognition models. We also evaluate the transferability of reconstructed face images when attacking different face recognition models. Our experimental results show that our reconstructed face images outperform previous reconstruction attacks against face recognition models.

We provide evidence of quantum kernel advantage under noiseless simulation in binary insurance classification on MIMIC-CXR chest radiographs using quantum support vector machines (QSVM) with frozen embeddings from three medical foundation models (MedSigLIP-448, RAD-DINO, ViT-patch32). We propose a two-tier fair comparison framework in which both classifiers receive identical PCA-q features. At Tier 1 (untuned QSVM vs. untuned linear SVM, C = 1 both sides), QSVM wins minority-class F1 in all 18 tested configurations (17 at p < 0.001, 1 at p < 0.01). The classical linear kernel collapses to majority-class prediction on 90-100% of seeds at every qubit count, while QSVM maintains non-trivial recall. At q = 11 (MedSigLIP-448 plateau center), QSVM achieves mean F1 = 0.343 vs. classical F1 = 0.050 (F1 gain = +0.293, p < 0.001) without hyperparameter tuning. Under Tier 2 (untuned QSVM vs. C-tuned RBF SVM), QSVM wins all seven tested configurations (mean gain +0.068, max +0.112). Eigenspectrum analysis reveals quantum kernel effective rank reaches 69.80 at q = 11, far exceeding linear kernel rank, while classical collapse remains C-invariant. A full qubit sweep reveals architecture-dependent concentration onset across models. Code: https://github.com/sebasmos/qml-medimage

We benchmark foundation models image embeddings for classification and retrieval in e-Commerce, evaluating their suitability for real-world applications. Our study spans embeddings from pre-trained convolutional and transformer models trained via supervised, self-supervised, and text-image contrastive learning. We assess full fine-tuning and transfer learning (top-tuning) on six diverse e-Commerce datasets: fashion, consumer goods, cars, food, and retail. Results show full fine-tuning consistently performs well, while text-image and self-supervised embeddings can match its performance with less training. While supervised embeddings remain stable across architectures, SSL and contrastive embeddings vary significantly, often benefiting from top-tuning. Top-tuning emerges as an efficient alternative to full fine-tuning, reducing computational costs. We also explore cross-tuning, noting its impact depends on dataset characteristics. Our findings offer practical guidelines for embedding selection and fine-tuning strategies, balancing efficiency and performance.

We present FIND, a generalized interface for aligning foundation models' embeddings. As shown in teaser figure, a lightweight transformer interface without tuning any foundation model weights is enough for a unified image (segmentation) and dataset-level (retrieval) understanding. The proposed interface has the following favorable attributes: (1) Generalizable. It applies to various tasks spanning retrieval, segmentation, etc., under the same architecture and weights. (2) Prototypable. Different tasks are able to be implemented through prototyping attention masks and embedding types. (3) Extendable. The proposed interface is adaptive to new tasks, and new models. (4) Interleavable. With the benefit of multi-task multi-modal training, the proposed interface creates an interleaved shared embedding space. In light of the interleaved embedding space, we introduce the FIND-Bench, which introduces new training and evaluation annotations to the COCO dataset for interleave segmentation and retrieval. Our approach achieves state-of-the-art performance on FIND-Bench and competitive performance on standard retrieval and segmentation settings. The training, evaluation, and demo code as well as the dataset have been released at https://github.com/UX-Decoder/FIND.

Accurate recognition of anatomical structures is essential for safe and effective minimally invasive surgery (MIS), yet it remains underexplored in surgical computer vision due to limited annotated data and methods tailored primarily to natural scenes. In this work, we present a combined dataset and model framework to advance anatomy-aware perception in MIS. First, we introduce ATLAS-120k, a large-scale clip-level semantic segmentation dataset comprising over 120,000 annotated frames from 100 surgical videos spanning 14 procedures and multiple modalities, including laparoscopic and robot-assisted surgery. The dataset captures substantial procedural variability and was created using a scalable annotation pipeline that integrates expert manual labeling, automated propagation, iterative refinement, and surgeon verification to ensure high-quality annotations. Second, we propose ATLAS (Anatomy Recognition with Context Learning using Foundation Representations), a video semantic segmentation model specifically designed for surgical anatomy recognition. Unlike conventional approaches that emphasize object tracking, ATLAS leverages foundation-model embeddings together with lightweight temporal reasoning to incorporate contextual cues such as procedure type, surgical phase, and short-term visual memory. This design enables temporally consistent and accurate predictions while maintaining real-time feasibility. Together, the dataset and model establish a practical foundation for robust surgical scene understanding and support the development of clinically applicable guidance systems for minimally invasive surgery. The models, dataset annotations and annotation platform are publicly available at: https://github.com/TimJaspers0801/ATLAS.

Genome engineering has achieved remarkable sequence-level precision, yet predicting the transcriptomic state that a cell will occupy after perturbation remains an open problem. Single-cell CRISPR screens measure how far cells move from their unperturbed state, but this effect magnitude ignores a fundamental question: do the cells move together? Two perturbations with identical magnitude can produce qualitatively different outcomes if one drives cells coherently along a shared trajectory while the other scatters them across expression space. We introduce a geometric stability metric, Shesha, that quantifies the directional coherence of single-cell perturbation responses as the mean cosine similarity between individual cell shift vectors and the mean perturbation direction. Across five CRISPR datasets (2,200+ perturbations spanning CRISPRa, CRISPRi, and pooled screens), stability correlates strongly with effect magnitude (Spearman ρ=0.75-0.97), with a calibrated cross-dataset correlation of 0.97. Crucially, discordant cases where the two metrics decouple expose regulatory architecture: pleiotropic master regulators such as CEBPA and GATA1 pay a "geometric tax," producing large but incoherent shifts, while lineage-specific factors such as KLF1 produce tightly coordinated responses. After controlling for magnitude, geometric instability is independently associated with elevated chaperone activation (HSPA5/BiP; ρ_{partial}=-0.34 and -0.21 across datasets), and the high-stability/high-stress quadrant is systematically depleted. The magnitude-stability relationship persists in scGPT foundation model embeddings, confirming it is a property of biological state space rather than linear projection. Perturbation stability provides a complementary axis for hit prioritization in screens, phenotypic quality control in cell manufacturing, and evaluation of in silico perturbation predictions.

This paper presents Arc2Face, an identity-conditioned face foundation model, which, given the ArcFace embedding of a person, can generate diverse photo-realistic images with an unparalleled degree of face similarity than existing models. Despite previous attempts to decode face recognition features into detailed images, we find that common high-resolution datasets (e.g. FFHQ) lack sufficient identities to reconstruct any subject. To that end, we meticulously upsample a significant portion of the WebFace42M database, the largest public dataset for face recognition (FR). Arc2Face builds upon a pretrained Stable Diffusion model, yet adapts it to the task of ID-to-face generation, conditioned solely on ID vectors. Deviating from recent works that combine ID with text embeddings for zero-shot personalization of text-to-image models, we emphasize on the compactness of FR features, which can fully capture the essence of the human face, as opposed to hand-crafted prompts. Crucially, text-augmented models struggle to decouple identity and text, usually necessitating some description of the given face to achieve satisfactory similarity. Arc2Face, however, only needs the discriminative features of ArcFace to guide the generation, offering a robust prior for a plethora of tasks where ID consistency is of paramount importance. As an example, we train a FR model on synthetic images from our model and achieve superior performance to existing synthetic datasets.

Real-time proactive agentic system, capable of modeling Human State of Mind, using foundation EXG model and text embeddings model, running fully offline on the edge. Unlike all previously known systems, the NeuroSkill(tm) system leverages SKILL.md description of Human's State of Mind via API and CLI provided by the system, directly from the Brain-Computer Interface (BCI) devices, which records Human biophysical and brain signals. Our custom harness - NeuroLoop(tm) - utilizes all of the above to run agentic flow that manages to engage with the Human on multiple cognitive and affective levels of their State of Mind (e.g., empathy), by providing actionable tool calls and protocol execution with explicit or implicit requests from the Human. GPLv3 open-source software with ethically aligned AI100 licensing for the skill markdown.

In hematology, computational models offer significant potential to improve diagnostic accuracy, streamline workflows, and reduce the tedious work of analyzing single cells in peripheral blood or bone marrow smears. However, clinical adoption of computational models has been hampered by the lack of generalization due to large batch effects, small dataset sizes, and poor performance in transfer learning from natural images. To address these challenges, we introduce DinoBloom, the first foundation model for single cell images in hematology, utilizing a tailored DINOv2 pipeline. Our model is built upon an extensive collection of 13 diverse, publicly available datasets of peripheral blood and bone marrow smears, the most substantial open-source cohort in hematology so far, comprising over 380,000 white blood cell images. To assess its generalization capability, we evaluate it on an external dataset with a challenging domain shift. We show that our model outperforms existing medical and non-medical vision models in (i) linear probing and k-nearest neighbor evaluations for cell-type classification on blood and bone marrow smears and (ii) weakly supervised multiple instance learning for acute myeloid leukemia subtyping by a large margin. A family of four DinoBloom models (small, base, large, and giant) can be adapted for a wide range of downstream applications, be a strong baseline for classification problems, and facilitate the assessment of batch effects in new datasets. All models are available at github.com/marrlab/DinoBloom.

Representation learning of pathology whole-slide images (WSIs) has primarily relied on weak supervision with Multiple Instance Learning (MIL). This approach leads to slide representations highly tailored to a specific clinical task. Self-supervised learning (SSL) has been successfully applied to train histopathology foundation models (FMs) for patch embedding generation. However, generating patient or slide level embeddings remains challenging. Existing approaches for slide representation learning extend the principles of SSL from patch level learning to entire slides by aligning different augmentations of the slide or by utilizing multimodal data. By integrating tile embeddings from multiple FMs, we propose a new single modality SSL method in feature space that generates useful slide representations. Our contrastive pretraining strategy, called COBRA, employs multiple FMs and an architecture based on Mamba-2. COBRA exceeds performance of state-of-the-art slide encoders on four different public CPTAC cohorts on average by at least +3.8% AUC, despite only being pretrained on 3048 WSIs from TCGA. Additionally, COBRA is readily compatible at inference time with previously unseen feature extractors.

Precisely perceiving the geometric and semantic properties of real-world 3D objects is crucial for the continued evolution of augmented reality and robotic applications. To this end, we present (), which incorporates vision-language embeddings of foundation models into 3D Gaussian Splatting (GS). The key contribution of this work is an efficient method to reconstruct and represent 3D vision-language models. This is achieved by distilling feature maps generated from image-based foundation models into those rendered from our 3D model. To ensure high-quality rendering and fast training, we introduce a novel scene representation by integrating strengths from both GS and multi-resolution hash encodings (MHE). Our effective training procedure also introduces a pixel alignment loss that makes the rendered feature distance of same semantic entities close, following the pixel-level semantic boundaries. Our results demonstrate remarkable multi-view semantic consistency, facilitating diverse downstream tasks, beating state-of-the-art methods by 10.2 percent on open-vocabulary language-based object detection, despite that we are 851times faster for inference. This research explores the intersection of vision, language, and 3D scene representation, paving the way for enhanced scene understanding in uncontrolled real-world environments. We plan to release the code upon paper acceptance.

Computational pathology relies on effective representation learning to support cancer research and precision medicine. Although self-supervised learning has driven major progress at the patch and whole-slide image levels, representation learning at the single-cell level remains comparatively underexplored, despite its importance for characterizing cell types and cellular phenotypes. We introduce LEMON (Learning Embeddings from Morphology Of Nuclei), a self-supervised foundation model for scalable single-cell image representation learning. Trained on millions of cell images from diverse tissues and cancer types, LEMON learns robust and versatile morphological representations that support large-scale single-cell analyses in pathology. We evaluate LEMON on five benchmark datasets across a range of prediction tasks and show that it provides strong performance, highlighting its potential as a new paradigm for cell-level computational pathology. Model weights are available at https://huggingface.co/aliceblondel/LEMON.

We introduce EarthPT -- an Earth Observation (EO) pretrained transformer. EarthPT is a 700 million parameter decoding transformer foundation model trained in an autoregressive self-supervised manner and developed specifically with EO use-cases in mind. We demonstrate that EarthPT is an effective forecaster that can accurately predict future pixel-level surface reflectances across the 400-2300 nm range well into the future. For example, forecasts of the evolution of the Normalised Difference Vegetation Index (NDVI) have a typical error of approximately 0.05 (over a natural range of -1 -> 1) at the pixel level over a five month test set horizon, out-performing simple phase-folded models based on historical averaging. We also demonstrate that embeddings learnt by EarthPT hold semantically meaningful information and could be exploited for downstream tasks such as highly granular, dynamic land use classification. Excitingly, we note that the abundance of EO data provides us with -- in theory -- quadrillions of training tokens. Therefore, if we assume that EarthPT follows neural scaling laws akin to those derived for Large Language Models (LLMs), there is currently no data-imposed limit to scaling EarthPT and other similar `Large Observation Models.'

This paper presents the Large Wireless Model (LWM) -- the world's first foundation model for wireless channels. Designed as a task-agnostic model, LWM generates universal, rich, contextualized channel embeddings (features) that potentially enhance performance across a wide range of downstream tasks in wireless communication and sensing systems. Towards this objective, LWM, which has a transformer-based architecture, was pre-trained in a self-supervised manner on large-scale wireless channel datasets. Our results show consistent improvements in classification and regression tasks when using the LWM embeddings compared to raw channel representations, especially in scenarios with high-complexity machine learning tasks and limited training datasets. This LWM's ability to learn from large-scale wireless data opens a promising direction for intelligent systems that can efficiently adapt to diverse tasks with limited data, paving the way for addressing key challenges in wireless communication and sensing systems.

Foundation models have transformed AI by reducing reliance on task-specific data through large-scale pretraining. While successful in language and vision, their adoption in EEG has lagged due to the heterogeneity of public datasets, which are collected under varying protocols, devices, and electrode configurations. Existing EEG foundation models struggle to generalize across these variations, often restricting pretraining to a single setup, resulting in suboptimal performance, in particular under linear probing. We present REVE (Representation for EEG with Versatile Embeddings), a pretrained model explicitly designed to generalize across diverse EEG signals. REVE introduces a novel 4D positional encoding scheme that enables it to process signals of arbitrary length and electrode arrangement. Using a masked autoencoding objective, we pretrain REVE on over 60,000 hours of EEG data from 92 datasets spanning 25,000 subjects, representing the largest EEG pretraining effort to date. REVE achieves state-of-the-art results on 10 downstream EEG tasks, including motor imagery classification, seizure detection, sleep staging, cognitive load estimation, and emotion recognition. With little to no fine-tuning, it demonstrates strong generalization, and nuanced spatio-temporal modeling. We release code, pretrained weights, and tutorials to support standardized EEG research and accelerate progress in clinical neuroscience.

Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified patient representation. We introduce Apollo, a multimodal temporal foundation model trained and evaluated on over three decades of longitudinal hospital records from a major US hospital system, composed of 25 billion records from 7.2 million patients, representing 28 distinct medical modalities and 12 major medical specialties. Apollo learns a unified representation space integrating over 100 thousand unique medical events in our clinical vocabulary as well as images and clinical text. This "atlas of medical concepts" forms a computational substrate for modeling entire patient care journeys comprised of sequences of structured and unstructured events, which are compressed by Apollo into virtual patient representations. To assess the potential of these whole-patient representations, we created 322 prognosis and retrieval tasks from a held-out test set of 1.4 million patients. We demonstrate the generalized clinical forecasting potential of Apollo embeddings, including predicting new disease onset risk up to five years in advance (95 tasks), disease progression (78 tasks), treatment response (59 tasks), risk of treatment-related adverse events (17 tasks), and hospital operations endpoints (12 tasks). Using feature attribution techniques, we show that model predictions align with clinically-interpretable multimodal biomarkers. We evaluate semantic similarity search on 61 retrieval tasks, and moreover demonstrate the potential of Apollo as a multimodal medical search engine using text and image queries. Together, these modeling capabilities establish the foundation for computable medicine, where the full context of patient care becomes accessible to computational reasoning.

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.

Industrial CAD workflows require robust, generalizable 3D geometric representations supporting accuracy and explainability. We introduce Shape, a self-supervised foundation model converting surface meshes into dense per-token embeddings. Shape combines a structured 3D latent grid, a multi-scale geometry-aware tokenizer (MAGNO) with cross-attention, and a transformer processor using grouped-query attention and RMSNorm. A learned reconstruction prior enables per-region attribution for explainable predictions. Pretraining uses masked-token reconstruction of normalized geometry statistics and multi-resolution contrastive consistency. The 10.9M-parameter backbone is pretrained on 61,052 CAD meshes from Thingi10K, MFCAD, and Fusion360. On a held-out split of 2,983 meshes, Shape achieves reconstruction R2 = 0.729 and 98.1% top-1 retrieval under the Wang-Isola protocol, with near-zero reconstruction train/val gap (contrastive scores use a larger evaluation pool). A 2x2 ablation on loss type and target-space normalization shows per-dimension normalization is critical: without it, performance collapses (R2 < 0.14, top-1 < 88%); with it, both losses succeed (R2 > 0.70, top-1 > 96%). Smooth-L1 offers secondary stability. Code, embeddings, and an interactive demo are released at https://github.com/simd-ai/shape.

Virtual immunohistochemistry (IHC) staining from hematoxylin and eosin (H&E) images can accelerate diagnostics by providing preliminary molecular insight directly from routine sections, reducing the need for repeat sectioning when tissue is limited. Existing methods improve realism through contrastive objectives, prototype matching, or domain alignment, yet the generator itself receives no direct guidance from pathology foundation models. We present UNIStainNet, a SPADE-UNet conditioned on dense spatial tokens from a frozen pathology foundation model (UNI), providing tissue-level semantic guidance for stain translation. A misalignment-aware loss suite preserves stain quantification accuracy, and learned stain embeddings enable a single model to serve multiple IHC markers simultaneously. On MIST, UNIStainNet achieves state-of-the-art distributional metrics on all four stains (HER2, Ki67, ER, PR) from a single unified model, where prior methods typically train separate per-stain models. On BCI, it also achieves the best distributional metrics. A tissue-type stratified failure analysis reveals that remaining errors are systematic, concentrating in non-tumor tissue. Code is available at https://github.com/facevoid/UNIStainNet.

Current challenges in developing foundational models for volumetric imaging data, such as magnetic resonance imaging (MRI), stem from the computational complexity of training state-of-the-art architectures in high dimensions and curating sufficiently large datasets of volumes. To address these challenges, we introduce Raptor (Random Planar Tensor Reduction), a train-free method for generating semantically rich embeddings for volumetric data. Raptor leverages a frozen 2D foundation model, pretrained on natural images, to extract visual tokens from individual cross-sections of medical volumes. These tokens are then spatially compressed using random projections, significantly reducing computational complexity while retaining semantic information. Extensive experiments on ten diverse medical volume tasks verify the superior performance of Raptor over state-of-the-art methods, including those pretrained exclusively on medical volumes (+3% SuPreM, +6% MISFM, +10% Merlin, +13% VoCo, and +14% SLIViT), while entirely bypassing the need for costly training. Our results highlight the effectiveness and versatility of Raptor as a foundation for advancing deep learning-based methods for medical volumes.

Since the inception of BERT, encoder-only Transformers have evolved significantly in computational efficiency, training stability, and long-context modeling. ModernBERT consolidates these advances by integrating Rotary Positional Embeddings (RoPE), FlashAttention, and refined normalization. Despite these developments, Turkish NLP lacks a monolingual encoder trained from scratch incorporating such modern architectural paradigms. This work introduces TabiBERT, a monolingual Turkish encoder based on ModernBERT architecture trained from scratch on a large, curated corpus. TabiBERT is pre-trained on one trillion tokens sampled from an 84.88B token multi-domain corpus: web text (73%), scientific publications (20%), source code (6%), and mathematical content (0.3%). The model supports 8,192-token context length (16x original BERT), achieves up to 2.65x inference speedup, and reduces GPU memory consumption, enabling larger batch sizes. We introduce TabiBench with 28 datasets across eight task categories with standardized splits and protocols, evaluated using GLUE-style macro-averaging. TabiBERT attains 77.58 on TabiBench, outperforming BERTurk by 1.62 points and establishing state-of-the-art on five of eight categories: question answering (+9.55), code retrieval (+2.41), and document retrieval (+0.60). Compared with task-specific prior best results, including specialized models like TurkishBERTweet, TabiBERT achieves +1.47 average improvement, indicating robust cross-domain generalization. We release model weights, training configurations, and evaluation code for transparent, reproducible Turkish encoder research.

Developing generalizable ML-based solutions for disparate learning problems in network security is highly desired. However, despite a rich history of applying ML to network security, most existing solutions lack generalizability. This lack of progress can be attributed to an overreliance on supervised learning techniques and the associated challenges of curating well-specified labeled training data. This paper addresses a fundamental gap by introducing a novel transformer-based network foundation model, netFound. We employ self-supervised learning techniques on abundant, unlabeled network telemetry data for pre-training. This pretrained model can subsequently be fine-tuned to create generalizable learning artifacts for disparate learning tasks, even when using commonly available but challenging labeled datasets that are sparse, noisy, and skewed. To realize this goal, netFound leverages various domain-specific attributes and constraints unique to network data (packet traces) by developing multi-modal embeddings, protocol-aware tokenization, data-driven token composition, and hierarchical transformers. Our results demonstrate that netFound's domain-specific design choices ensure that it (1) effectively captures the hidden networking context in production settings, (2) outperforms four different SOTA methods on five different learning tasks, and (3) is robust to both noisy labels and learning shortcuts -- critical for developing generalizable ML models in practical settings.

Computational pathology needs whole-slide image (WSI) foundation models that transfer across diverse clinical tasks, yet current approaches remain largely slide-centric, often depend on private data and expensive paired-report supervision, and do not explicitly model relationships among multiple slides from the same patient. We present MOOZY, a patient-first pathology foundation model in which the patient case, not the individual slide, is the core unit of representation. MOOZY explicitly models dependencies across all slides from the same patient via a case transformer during pretraining, combining multi-stage open self-supervision with scaled low-cost task supervision. In Stage 1, we pretrain a vision-only slide encoder on 77,134 public slide feature grids using masked self-distillation. In Stage 2, we align these representations with clinical semantics using a case transformer and multi-task supervision over 333 tasks from 56 public datasets, including 205 classification and 128 survival tasks across four endpoints. Across eight held-out tasks with five-fold frozen-feature probe evaluation, MOOZY achieves best or tied-best performance on most metrics and improves macro averages over TITAN by +7.37%, +5.50%, and +7.83% and over PRISM by +8.83%, +10.70%, and +9.78% for weighted F1, weighted ROC-AUC, and balanced accuracy, respectively. MOOZY is also parameter efficient with 85.77M parameters, 14x smaller than GigaPath. These results demonstrate that open, reproducible patient-level pretraining yields transferable embeddings, providing a practical path toward scalable patient-first histopathology foundation models.

Pathology foundation models (FMs) have driven significant progress in computational pathology. However, these high-performing models can easily exceed a billion parameters and produce high-dimensional embeddings, thus limiting their applicability for research or clinical use when computing resources are tight. Here, we introduce Pathryoshka, a multi-teacher distillation framework inspired by RADIO distillation and Matryoshka Representation Learning to reduce pathology FM sizes while allowing for adaptable embedding dimensions. We evaluate our framework with a distilled model on ten public pathology benchmarks with varying downstream tasks. Compared to its much larger teachers, Pathryoshka reduces the model size by 86-92% at on-par performance. It outperforms state-of-the-art single-teacher distillation models of comparable size by a median margin of 7.0 in accuracy. By enabling efficient local deployment without sacrificing accuracy or representational richness, Pathryoshka democratizes access to state-of-the-art pathology FMs for the broader research and clinical community.

The long-standing dominance of gradient-boosted decision trees on tabular data is currently challenged by tabular foundation models using In-Context Learning (ICL): setting the training data as context for the test data and predicting in a single forward pass without parameter updates. While the very recent TabPFNv2 foundation model (2025) excels on tables with up to 10K samples, its alternating column- and row-wise attentions make handling large training sets computationally prohibitive. So, can ICL be effectively scaled and deliver a benefit for larger tables? We introduce TabICL, a tabular foundation model for classification, pretrained on synthetic datasets with up to 60K samples and capable of handling 500K samples on affordable resources. This is enabled by a novel two-stage architecture: a column-then-row attention mechanism to build fixed-dimensional embeddings of rows, followed by a transformer for efficient ICL. Across 200 classification datasets from the TALENT benchmark, TabICL is on par with TabPFNv2 while being systematically faster (up to 10 times), and significantly outperforms all other approaches. On 56 datasets with over 10K samples, TabICL surpasses both TabPFNv2 and CatBoost, demonstrating the potential of ICL for large data.

Cardiac biosignals, such as electrocardiograms (ECG) and photoplethysmograms (PPG), are of paramount importance for the diagnosis, prevention, and management of cardiovascular diseases, and have been extensively used in a variety of clinical tasks. Conventional deep learning approaches for analyzing these signals typically rely on homogeneous datasets and static bespoke models, limiting their robustness and generalizability across diverse clinical settings and acquisition protocols. In this study, we present a cardiac sensing foundation model (CSFM) that leverages advanced transformer architectures and a generative, masked pretraining strategy to learn unified representations from vast, heterogeneous health records. Our model is pretrained on an innovative multi-modal integration of data from multiple large-scale datasets (including MIMIC-III-WDB, MIMIC-IV-ECG, and CODE), comprising cardiac signals and the corresponding clinical or machine-generated text reports from approximately 1.7 million individuals. We demonstrate that the embeddings derived from our CSFM not only serve as effective feature extractors across diverse cardiac sensing scenarios, but also enable seamless transfer learning across varying input configurations and sensor modalities. Extensive evaluations across diagnostic tasks, demographic information recognition, vital sign measurement, clinical outcome prediction, and ECG question answering reveal that CSFM consistently outperforms traditional one-modal-one-task approaches. Notably, CSFM exhibits robust performance across multiple ECG lead configurations from standard 12-lead systems to single-lead setups, and in scenarios where only ECG, only PPG, or a combination thereof is available. These findings highlight the potential of CSFM as a versatile and scalable solution, for comprehensive cardiac monitoring.

Electroencephalography (EEG) and magnetoencephalography (MEG) measure neural activity non-invasively by capturing electromagnetic fields generated by dendritic currents. Although rooted in the same biophysics, EEG and MEG exhibit distinct signal patterns, further complicated by variations in sensor configurations across modalities and recording devices. Existing approaches typically rely on separate, modality- and dataset-specific models, which limits the performance and cross-domain scalability. This paper proposes BrainOmni, the first brain foundation model that generalises across heterogeneous EEG and MEG recordings. To unify diverse data sources, we introduce BrainTokenizer,the first tokenizer that quantises spatiotemporal brain activity into discrete representations. Central to BrainTokenizer is a novel Sensor Encoder that encodes sensor properties such as spatial layout, orientation, and type, enabling compatibility across devices and modalities. Building upon the discrete representations, BrainOmni learns unified semantic embeddings of brain signals by self-supervised pretraining. To the best of our knowledge, it is the first foundation model to support both EEG and MEG signals, as well as the first to incorporate large-scale MEG pretraining. A total of 1,997 hours of EEG and 656 hours of MEG data are curated and standardised from publicly available sources for pretraining. Experiments show that BrainOmni outperforms both existing foundation models and state-of-the-art task-specific models on a range of downstream tasks. It also demonstrates strong generalisation to unseen EEG and MEG devices. Further analysis reveals that joint EEG-MEG (EMEG) training yields consistent improvements across both modalities. Code and model checkpoints will be released upon acceptance.

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often lack biomedical text annotation and enrichment. Guiding data-efficient image diagnosis from the use of biomedical text knowledge becomes a substantial interest. In this paper, we propose to Connect Image and Text Embeddings (CITE) to enhance pathological image classification. CITE injects text insights gained from language models pre-trained with a broad range of biomedical texts, leading to adapt foundation models towards pathological image understanding. Through extensive experiments on the PatchGastric stomach tumor pathological image dataset, we demonstrate that CITE achieves leading performance compared with various baselines especially when training data is scarce. CITE offers insights into leveraging in-domain text knowledge to reinforce data-efficient pathological image classification. Code is available at https://github.com/Yunkun-Zhang/CITE.

General-purpose foundation models have become increasingly important in the field of artificial intelligence. While self-supervised learning (SSL) and Masked Image Modeling (MIM) have led to promising results in building such foundation models for remote sensing, these models primarily learn low-level features, require annotated data for fine-tuning, and not applicable for retrieval and zero-shot applications due to the lack of language understanding. In response to these limitations, we propose RemoteCLIP, the first vision-language foundation model for remote sensing that aims to learn robust visual features with rich semantics, as well as aligned text embeddings for seamless downstream application. To address the scarcity of pre-training data, we leverage data scaling, converting heterogeneous annotations based on Box-to-Caption (B2C) and Mask-to-Box (M2B) conversion, and further incorporating UAV imagery, resulting a 12xlarger pretraining dataset. RemoteCLIP can be applied to a variety of downstream tasks, including zero-shot image classification, linear probing, k-NN classification, few-shot classification, image-text retrieval, and object counting. Evaluations on 16 datasets, including a newly introduced RemoteCount benchmark to test the object counting ability, show that RemoteCLIP consistently outperforms baseline foundation models across different model scales. Impressively, RemoteCLIP outperform previous SoTA by 9.14% mean recall on RSICD dataset and by 8.92% on RSICD dataset. For zero-shot classification, our RemoteCLIP outperform CLIP baseline by up to 6.39% average accuracy on 12 downstream datasets.

Recent progress in unified models for image understanding and generation has been impressive, yet most approaches remain limited to single-modal generation conditioned on multiple modalities. In this paper, we present Mogao, a unified framework that advances this paradigm by enabling interleaved multi-modal generation through a causal approach. Mogao integrates a set of key technical improvements in architecture design, including a deep-fusion design, dual vision encoders, interleaved rotary position embeddings, and multi-modal classifier-free guidance, which allow it to harness the strengths of both autoregressive models for text generation and diffusion models for high-quality image synthesis. These practical improvements also make Mogao particularly effective to process interleaved sequences of text and images arbitrarily. To further unlock the potential of unified models, we introduce an efficient training strategy on a large-scale, in-house dataset specifically curated for joint text and image generation. Extensive experiments show that Mogao not only achieves state-of-the-art performance in multi-modal understanding and text-to-image generation, but also excels in producing high-quality, coherent interleaved outputs. Its emergent capabilities in zero-shot image editing and compositional generation highlight Mogao as a practical omni-modal foundation model, paving the way for future development and scaling the unified multi-modal systems.

We present the NCS-models, a family of seismic foundation models pretrained on a large share of full-stack seismic cubes from the Norwegian Continental Shelf (NCS) available through the public DISKOS database. The model weights are open-sourced for the wider geoscience community. Foundation models trained with large-scale self-supervision are emerging as a promising basis for automatic seismic interpretation. However, most existing seismic models rely on limited or proprietary datasets, and it remains unclear how well natural-image foundation models transfer to seismic data. Our goals are to develop basin-scale seismic foundation models, provide practical recipes for scalable 3D training, and quantify the effects of basin-targeted pretraining and token dimensionality on downstream interpretation performance. Using masked autoencoders with Vision Transformer backbones, we pretrain models on a DISKOS-derived corpus of 3D time- and depth-migrated seismic volumes. The NCS-model variants use 2D, 2.5D multi-view, and 3D tokenization within a matched training setup. Transfer is evaluated on interpretation benchmarks using frozen backbones and a simple k-nearest neighbor classifier. Baselines include an ImageNet-pretrained MAE, a frontier vision foundation model, and a globally pretrained seismic model. Natural-image pretrained models do not reliably transfer, reflecting the large domain gap between natural images and seismic data. Seismic pretraining is necessary for robust transfer, and large-scale basin-targeted pretraining yields further gains over a smaller globally pretrained seismic baseline. The NCS-models achieve the best overall performance without fine-tuning, while 2.5D tokenization offers the strongest accuracy-efficiency tradeoff and the embeddings support similarity search for interactive interpretation.

Modern Earth observation (EO) increasingly leverages deep learning to harness the scale and diversity of satellite imagery across sensors and regions. While recent foundation models have demonstrated promising generalization across EO tasks, many remain limited by the scale, geographical coverage, and spectral diversity of their training data, factors critical for learning globally transferable representations. In this work, we introduce TerraFM, a scalable self-supervised learning model that leverages globally distributed Sentinel-1 and Sentinel-2 imagery, combined with large spatial tiles and land-cover aware sampling to enrich spatial and semantic coverage. By treating sensing modalities as natural augmentations in our self-supervised approach, we unify radar and optical inputs via modality-specific patch embeddings and adaptive cross-attention fusion. Our training strategy integrates local-global contrastive learning and introduces a dual-centering mechanism that incorporates class-frequency-aware regularization to address long-tailed distributions in land cover.TerraFM achieves strong generalization on both classification and segmentation tasks, outperforming prior models on GEO-Bench and Copernicus-Bench. Our code and pretrained models are publicly available at: https://github.com/mbzuai-oryx/TerraFM .

Geospatial raster data, such as that collected by satellite-based imaging systems at different times and spectral bands, hold immense potential for enabling a wide range of high-impact applications. This potential stems from the rich information that is spatially and temporally contextualized across multiple channels and sensing modalities. Recent work has adapted existing self-supervised learning approaches for such geospatial data. However, they fall short of scalable model architectures, leading to inflexibility and computational inefficiencies when faced with an increasing number of channels and modalities. To address these limitations, we introduce Low-rank Efficient Spatial-Spectral Vision Transformer with three key innovations: i) the LESS Attention Block that approximates high-dimensional spatial-spectral attention through Kronecker's product of the low-dimensional spatial and spectral attention components; ii) the Continuous Positional-Channel Embedding Layer that preserves both the continuity and physical characteristics of each spatial-spectral patch; and iii) the Perception Field Mask that exploits local spatial dependencies by constraining attention to neighboring patches. To evaluate the proposed innovations, we construct GFM-Bench, which serves as a comprehensive benchmark for such geospatial raster data. We pretrain LESS ViT using a Hyperspectral Masked Autoencoder framework with integrated positional and channel masking strategies. Experimental results demonstrate that our proposed method achieves competitive performance against state-of-the-art multi-modal geospatial foundation models while outperforming them on cross-satellite generalization tasks with higher computational efficiency. The flexibility and extensibility of our framework make it a promising direction for future geospatial data analysis tasks that involve a wide range of modalities and channels.

We present a transformer architecture-based foundation model for tasks at high-energy particle colliders such as the Large Hadron Collider. We train the model to classify jets using a self-supervised strategy inspired by the Joint Embedding Predictive Architecture. We use the JetClass dataset containing 100M jets of various known particles to pre-train the model with a data-centric approach -- the model uses a fraction of the jet constituents as the context to predict the embeddings of the unseen target constituents. Our pre-trained model fares well with other datasets for standard classification benchmark tasks. We test our model on two additional downstream tasks: top tagging and differentiating light-quark jets from gluon jets. We also evaluate our model with task-specific metrics and baselines and compare it with state-of-the-art models in high-energy physics. Project site: https://hep-jepa.github.io/

Language promptable X-ray image segmentation would enable greater flexibility for human-in-the-loop workflows in diagnostic and interventional precision medicine. Prior efforts have contributed task-specific models capable of solving problems within a narrow scope, but expanding to broader use requires additional data, annotations, and training time. Recently, language-aligned foundation models (LFMs) -- machine learning models trained on large amounts of highly variable image and text data thus enabling broad applicability -- have emerged as promising tools for automated image analysis. Existing foundation models for medical image analysis focus on scenarios and modalities where large, richly annotated datasets are available. However, the X-ray imaging modality features highly variable image appearance and applications, from diagnostic chest X-rays to interventional fluoroscopy, with varying availability of data. To pave the way toward an LFM for comprehensive and language-aligned analysis of arbitrary medical X-ray images, we introduce FluoroSAM, a language-promptable variant of the Segment Anything Model, trained from scratch on 3M synthetic X-ray images from a wide variety of human anatomies, imaging geometries, and viewing angles. These include pseudo-ground truth masks for 128 organ types and 464 tools with associated text descriptions. FluoroSAM is capable of segmenting myriad anatomical structures and tools based on natural language prompts, thanks to the novel incorporation of vector quantization (VQ) of text embeddings in the training process. We demonstrate FluoroSAM's performance quantitatively on real X-ray images and showcase on several applications how FluoroSAM is a key enabler for rich human-machine interaction in the X-ray image acquisition and analysis context. Code is available at https://github.com/arcadelab/fluorosam.

Foundation models deliver strong perception but are often too computationally heavy to deploy, and adapting them typically requires costly annotations. We introduce a semi-supervised knowledge distillation (SSKD) framework that compresses pre-trained vision foundation models (VFMs) into compact experts using limited labeled and abundant unlabeled data, and instantiate it for instance segmentation where per-pixel labels are particularly expensive. The framework unfolds in three stages: (1) domain adaptation of the VFM(s) via self-training with contrastive calibration, (2) knowledge transfer through a unified multi-objective loss, and (3) student refinement to mitigate residual pseudo-label bias. Central to our approach is an instance-aware pixel-wise contrastive loss that fuses mask and class scores to extract informative negatives and enforce clear inter-instance margins. By maintaining this contrastive signal across both adaptation and distillation, we align teacher and student embeddings and more effectively leverage unlabeled images. On Cityscapes and ADE20K, our approx 11times smaller student improves over its zero-shot VFM teacher(s) by +11.9 and +8.6 AP, surpasses adapted teacher(s) by +3.4 and +1.5 AP, and outperforms state-of-the-art SSKD methods on benchmarks.

Large-scale foundation models (LFMs) have recently made impressive progress in text-to-motion generation by learning strong generative priors from massive 3D human motion datasets and paired text descriptions. However, how to effectively and efficiently leverage such single-purpose motion LFMs, i.e., text-to-motion synthesis, in more diverse cross-modal and in-context motion generation downstream tasks remains largely unclear. Prior work typically adapts pretrained generative priors to individual downstream tasks in a task-specific manner. In contrast, our goal is to unlock such priors to support a broad spectrum of downstream motion generation tasks within a single unified framework. To bridge this gap, we present UMO, a simple yet general unified formulation that casts diverse downstream tasks into compositions of atomic per-frame operations, enabling in-context adaptation to unlock the generative priors of pretrained DiT-based motion LFMs. Specifically, UMO introduces three learnable frame-level meta-operation embeddings to specify per-frame intent and employs lightweight temporal fusion to inject in-context cues into the pretrained backbone, with negligible runtime overhead compared to the base model. With this design, UMO finetunes the pretrained model, originally limited to text-to-motion generation, to support diverse previously unsupported tasks, including temporal inpainting, text-guided motion editing, text-serialized geometric constraints, and multi-identity reaction generation. Experiments demonstrate that UMO consistently outperforms task-specific and training-free baselines across a wide range of benchmarks, despite using a single unified model. Code and model will be publicly available. Project Page: https://oliver-cong02.github.io/UMO.github.io/

Cancer progression arises from interactions across multiple biological layers, especially beyond morphological and across molecular layers that remain invisible to image-only models. To capture this broader biological landscape, we present EXAONE Path 2.5, a pathology foundation model that jointly models histologic, genomic, epigenetic and transcriptomic modalities, producing an integrated patient representation that reflects tumor biology more comprehensively. Our approach incorporates three key components: (1) multimodal SigLIP loss enabling all-pairwise contrastive learning across heterogeneous modalities, (2) a fragment-aware rotary positional encoding (F-RoPE) module that preserves spatial structure and tissue-fragment topology in WSI, and (3) domain-specialized internal foundation models for both WSI and RNA-seq to provide biologically grounded embeddings for robust multimodal alignment. We evaluate EXAONE Path 2.5 against six leading pathology foundation models across two complementary benchmarks: an internal real-world clinical dataset and the Patho-Bench benchmark covering 80 tasks. Our framework demonstrates high data and parameter efficiency, achieving on-par performance with state-of-the-art foundation models on Patho-Bench while exhibiting the highest adaptability in the internal clinical setting. These results highlight the value of biologically informed multimodal design and underscore the potential of integrated genotype-to-phenotype modeling for next-generation precision oncology.

Knowledge Graph Foundation Models (KGFMs) have shown promise in enabling zero-shot reasoning over unseen graphs by learning transferable patterns. However, most existing KGFMs rely solely on graph structure, overlooking the rich semantic signals encoded in textual attributes. We introduce SEMMA, a dual-module KGFM that systematically integrates transferable textual semantics alongside structure. SEMMA leverages Large Language Models (LLMs) to enrich relation identifiers, generating semantic embeddings that subsequently form a textual relation graph, which is fused with the structural component. Across 54 diverse KGs, SEMMA outperforms purely structural baselines like ULTRA in fully inductive link prediction. Crucially, we show that in more challenging generalization settings, where the test-time relation vocabulary is entirely unseen, structural methods collapse while SEMMA is 2x more effective. Our findings demonstrate that textual semantics are critical for generalization in settings where structure alone fails, highlighting the need for foundation models that unify structural and linguistic signals in knowledge reasoning.

Modern astronomical surveys, such as the Euclid mission, produce high-dimensional, multi-modal data sets that include imaging and spectroscopic information for millions of galaxies. These data serve as an ideal benchmark for large, pre-trained multi-modal models, which can leverage vast amounts of unlabelled data. In this work, we present the first exploration of Euclid data with AstroPT, an autoregressive multi-modal foundation model trained on approximately 300 000 optical and infrared Euclid images and spectral energy distributions (SEDs) from the first Euclid Quick Data Release. We compare self-supervised pre-training with baseline fully supervised training across several tasks: galaxy morphology classification; redshift estimation; similarity searches; and outlier detection. Our results show that: (a) AstroPT embeddings are highly informative, correlating with morphology and effectively isolating outliers; (b) including infrared data helps to isolate stars, but degrades the identification of edge-on galaxies, which are better captured by optical images; (c) simple fine-tuning of these embeddings for photometric redshift and stellar mass estimation outperforms a fully supervised approach, even when using only 1% of the training labels; and (d) incorporating SED data into AstroPT via a straightforward multi-modal token-chaining method improves photo-z predictions, and allow us to identify potentially more interesting anomalies (such as ringed or interacting galaxies) compared to a model pre-trained solely on imaging data.

Recent text-to-video diffusion models can generate compelling video sequences, yet they remain silent -- missing the semantic, emotional, and atmospheric cues that audio provides. We introduce LTX-2, an open-source foundational model capable of generating high-quality, temporally synchronized audiovisual content in a unified manner. LTX-2 consists of an asymmetric dual-stream transformer with a 14B-parameter video stream and a 5B-parameter audio stream, coupled through bidirectional audio-video cross-attention layers with temporal positional embeddings and cross-modality AdaLN for shared timestep conditioning. This architecture enables efficient training and inference of a unified audiovisual model while allocating more capacity for video generation than audio generation. We employ a multilingual text encoder for broader prompt understanding and introduce a modality-aware classifier-free guidance (modality-CFG) mechanism for improved audiovisual alignment and controllability. Beyond generating speech, LTX-2 produces rich, coherent audio tracks that follow the characters, environment, style, and emotion of each scene -- complete with natural background and foley elements. In our evaluations, the model achieves state-of-the-art audiovisual quality and prompt adherence among open-source systems, while delivering results comparable to proprietary models at a fraction of their computational cost and inference time. All model weights and code are publicly released.

Multimodal embedding models aim to yield informative unified representations that empower diverse cross-modal tasks. Despite promising developments in the evolution from CLIP-based dual-tower architectures to large vision-language models, prior works still face unavoidable challenges in real-world applications and business scenarios, such as the limited modality support, unstable training mechanisms, and industrial domain gaps. In this work, we introduce SAIL-Embedding, an omni-modal embedding foundation model that addresses these issues through tailored training strategies and architectural design. In the optimization procedure, we propose a multi-stage training scheme to boost the multifaceted effectiveness of representation learning. Specifically, the content-aware progressive training aims to enhance the model's adaptability to diverse downstream tasks and master enriched cross-modal proficiency. The collaboration-aware recommendation enhancement training further adapts multimodal representations for recommendation scenarios by distilling knowledge from sequence-to-item and ID-to-item embeddings while mining user historical interests. Concurrently, we develop the stochastic specialization and dataset-driven pattern matching to strengthen model training flexibility and generalizability. Experimental results show that SAIL-Embedding achieves SOTA performance compared to other methods in different retrieval tasks. In online experiments across various real-world scenarios integrated with our model, we observe a significant increase in Lifetime (LT), which is a crucial indicator for the recommendation experience. For instance, the model delivers the 7-day LT gain of +0.158% and the 14-day LT gain of +0.144% in the Douyin-Selected scenario. For the Douyin feed rank model, the match features produced by SAIL-Embedding yield a +0.08% AUC gain.

This technical report presents Prithvi-EO-2.0, a new geospatial foundation model that offers significant improvements over its predecessor, Prithvi-EO-1.0. Trained on 4.2M global time series samples from NASA's Harmonized Landsat and Sentinel-2 data archive at 30m resolution, the new 300M and 600M parameter models incorporate temporal and location embeddings for enhanced performance across various geospatial tasks. Through extensive benchmarking with GEO-Bench, the 600M version outperforms the previous Prithvi-EO model by 8\% across a range of tasks. It also outperforms six other geospatial foundation models when benchmarked on remote sensing tasks from different domains and resolutions (i.e. from 0.1m to 15m). The results demonstrate the versatility of the model in both classical earth observation and high-resolution applications. Early involvement of end-users and subject matter experts (SMEs) are among the key factors that contributed to the project's success. In particular, SME involvement allowed for constant feedback on model and dataset design, as well as successful customization for diverse SME-led applications in disaster response, land use and crop mapping, and ecosystem dynamics monitoring. Prithvi-EO-2.0 is available on Hugging Face and IBM terratorch, with additional resources on GitHub. The project exemplifies the Trusted Open Science approach embraced by all involved organizations.

We present TokaMind, an open-source foundation model framework for fusion plasma modeling, based on a Multi-Modal Transformer (MMT) and trained on heterogeneous tokamak diagnostics from the publicly available MAST dataset. TokaMind supports multiple data modalities (time-series, 2D profiles, and videos) with different sampling rates, robust missing-signal handling, and efficient task adaptation via selectively loading and freezing four model components. To represent multi-modal signals, we use a training-free Discrete Cosine Transform embedding (DCT3D) and provide a clean interface for alternative embeddings (e.g., Variational Autoencoders - VAEs). We evaluate TokaMind on the recently introduced MAST benchmark TokaMark, comparing training and embedding strategies. Our results show that fine-tuned TokaMind outperforms the benchmark baseline on all but one task, and that, for several tasks, lightweight fine-tuning yields better performance than training the same architecture from scratch under a matched epoch budget. These findings highlight the benefits of multi-modal pretraining for tokamak plasma dynamics and provide a practical, extensible foundation for future fusion modeling tasks. Training code and model weights will be made publicly available.

Deep learning models facilitate the discovery of molecules with tailored properties among billions of candidate compounds. However, the computational burden to develop and deploy state-of-the-art models continuously increases, limiting their scalability. Most large-scale models are unimodal in nature and overlook the potential to leverage complementary molecular data modalities. To address these shortcomings, this paper introduces the Graph-Language Alignment for Chemical Inference and Exploration using Representations (GLACIER) model, a student-teacher framework that integrates molecular graphs, SMILES strings, and physicochemical descriptors to learn rich molecular embeddings. Our framework consists of three stages: (1) we pretrain three student encoders on 100,000 drug-like molecules: a message-passing neural network for molecular graphs, a transformer-based encoder for SMILES strings, and a multilayer perceptron for physicochemical descriptors, (2) we fuse these student modalities using a novel Finsler geometry-aware module, and (3) distill complementary knowledge from large teacher models, including MiniMol and MolFormer, into a single lightweight model via contrastive learning. We demonstrate that GLACIER is a robust framework that delivers high predictive performance and computational efficiency in complex molecular property prediction tasks. Our code is publicly available at https://github.com/eemokey/glacier.

Satellite Earth-observation (EO) time series in the optical and microwave ranges of the electromagnetic spectrum are often irregular due to orbital patterns and cloud obstruction. Compositing addresses these issues but loses information with respect to vegetation phenology, which is critical for many downstream tasks. Instead, we present TESSERA, a pixel-wise foundation model for multi-modal (Sentinel-1/2) EO time series that learns robust, label-efficient embeddings. During model training, TESSERA uses Barlow Twins and sparse random temporal sampling to enforce invariance to the selection of valid observations. We employ two key regularizers: global shuffling to decorrelate spatial neighborhoods and mix-based regulation to improve invariance under extreme sparsity. We find that for diverse classification, segmentation, and regression tasks, TESSERA embeddings deliver state-of-the-art accuracy with high label efficiency, often requiring only a small task head and minimal computation. To democratize access, adhere to FAIR - principles, and simplify use, we release global, annual, 10m, pixel-wise int8 embeddings together with open weights/code and lightweight adaptation heads, thus providing practical tooling for large-scale retrieval and inference at planetary scale. All code and data are available at: https://github.com/ucam-eo/tessera.

Physiological foundation models (FMs) have shown promise for biosignal representation learning, yet most remain confined to a single modality such as EEG, ECG, or PPG, largely because paired multimodal datasets are scarce. In this paper, we present PanLUNA, a compact 5.4M-parameter pan-modal FM that jointly processes EEG, ECG, and PPG within a single shared encoder. Extending LUNA's channel-unification module, PanLUNA treats multimodal channels as entries in a unified query set augmented with sensor-type embeddings, enabling efficient cross-modal early fusion while remaining inherently robust to missing modalities at inference time. Despite its small footprint, PanLUNA matches or exceeds models up to 57times larger: 81.21% balanced accuracy on TUAB abnormal EEG detection and state-of-the-art 0.7416 balanced accuracy on HMC multimodal sleep staging. Quantization-aware training with INT8 weights recovers geq96% of full-precision performance, and deployment on the GAP9 ultra-low-power RISC-V microcontroller for wearables achieves 325.6 ms latency and 18.8 mJ per 10-second, 12-lead ECG inference, and 1.206 s latency at 68.65 mJ for multimodal 5-channel sleep staging over 30-second epochs.

Egocentric video-language understanding demands both high efficiency and accurate spatial-temporal modeling. Existing approaches face three key challenges: 1) Excessive pre-training cost arising from multi-stage pre-training pipelines, 2) Ineffective spatial-temporal encoding due to manually split 3D rotary positional embeddings that hinder feature interactions, and 3) Imprecise learning objectives in soft-label multi-instance retrieval, which neglect negative pair correlations. In this paper, we introduce EVA02-AT, a suite of EVA02-based video-language foundation models tailored to egocentric video understanding tasks. EVA02-AT first efficiently transfers an image-based CLIP model into a unified video encoder via a single-stage pretraining. Second, instead of applying rotary positional embeddings to isolated dimensions, we introduce spatial-temporal rotary positional embeddings along with joint attention, which can effectively encode both spatial and temporal information on the entire hidden dimension. This joint encoding of spatial-temporal features enables the model to learn cross-axis relationships, which are crucial for accurately modeling motion and interaction in videos. Third, focusing on multi-instance video-language retrieval tasks, we introduce the Symmetric Multi-Similarity (SMS) loss and a novel training framework that advances all soft labels for both positive and negative pairs, providing a more precise learning objective. Extensive experiments on Ego4D, EPIC-Kitchens-100, and Charades-Ego under zero-shot and fine-tuning settings demonstrate that EVA02-AT achieves state-of-the-art performance across diverse egocentric video-language tasks with fewer parameters. Models with our SMS loss also show significant performance gains on multi-instance retrieval benchmarks. Our code and models are publicly available at https://github.com/xqwang14/EVA02-AT .

Time series foundation models (TSFMs) have emerged as a powerful paradigm for time series analysis, driven by large-scale pretraining on diverse data corpora. However, time series inherently exhibit heterogeneous information density over time, influenced by system states and signal complexity, presenting significant modeling challenges especially in a zero-shot scenario. Current TSFMs rely on non-adaptive processing pipelines that fail to capture this dynamic nature. For example, common tokenization strategies such as fixed-size patching enforce rigid observational granularity, limiting their ability to adapt to varying information densities. Similarly, conventional positional encodings impose a uniform temporal scale, making it difficult to model diverse periodicities and trends across series. To overcome these limitations, we propose Kairos, a flexible TSFM framework that integrates a dynamic patching tokenizer and an instance-adaptive positional embedding. Kairos adaptively selects tokenization granularity and tailors positional encodings to the unique characteristics of each time series instance. Trained on a large-scale Predictability-Stratified Time Series (PreSTS) corpus comprising over 300 billion time points and adopting a multi-patch prediction strategy in the inference stage, Kairos achieves superior performance with much fewer parameters on two common zero-shot benchmarks, GIFT-Eval and the Time-Series-Library benchmark, consistently outperforming established methods across diverse tasks. The project page is at https://foundation-model-research.github.io/Kairos .

Hollmann et al. (Nature 637 (2025) 319-326) recently introduced TabPFN, a transformer-based deep learning model for regression and classification on tabular data, which they claim "outperforms all previous methods on datasets with up to 10,000 samples by a wide margin, using substantially less training time." Furthermore, they have called TabPFN a "foundation model" for tabular data, as it can support "data generation, density estimation, learning reusable embeddings and fine-tuning". In this paper, we provide a tailored explanation of how TabPFN works for a statistics audience, by emphasizing its interpretation as approximate Bayesian inference. We then explore the significance of TabPFN to the field of statistics: We show that an out-of-the-box application of TabPFN can sometimes outperform specialized state-of-the-art methods for semi-supervised parameter estimation, prediction under covariate shift, and heterogeneous treatment effect estimation. As a partial explanation for the predictive effectiveness of TabPFN, we show that it can simultaneously adapt to both nonparametric structure and parametric structure, for instance, sometimes outperforming LASSO even when assumptions are correctly specified. All experiments can be reproduced using the code provided at https://github.com/qinglong-tian/tabpfn_study (https://github.com/qinglong-tian/tabpfn_study).

Effective DNA embedding remains crucial in genomic analysis, particularly in scenarios lacking labeled data for model fine-tuning, despite the significant advancements in genome foundation models. A prime example is metagenomics binning, a critical process in microbiome research that aims to group DNA sequences by their species from a complex mixture of DNA sequences derived from potentially thousands of distinct, often uncharacterized species. To fill the lack of effective DNA embedding models, we introduce DNABERT-S, a genome foundation model that specializes in creating species-aware DNA embeddings. To encourage effective embeddings to error-prone long-read DNA sequences, we introduce Manifold Instance Mixup (MI-Mix), a contrastive objective that mixes the hidden representations of DNA sequences at randomly selected layers and trains the model to recognize and differentiate these mixed proportions at the output layer. We further enhance it with the proposed Curriculum Contrastive Learning (C^2LR) strategy. Empirical results on 18 diverse datasets showed DNABERT-S's remarkable performance. It outperforms the top baseline's performance in 10-shot species classification with just a 2-shot training while doubling the Adjusted Rand Index (ARI) in species clustering and substantially increasing the number of correctly identified species in metagenomics binning. The code, data, and pre-trained model are publicly available at https://github.com/Zhihan1996/DNABERT_S.

Pre-trained foundation models have demonstrated remarkable success in vision and language, yet their potential for general machine signal modeling-covering acoustic, vibration, and other industrial sensor data-remains under-explored. Existing approach using sub-band-based encoders has achieved competitive results but are limited by fixed input lengths, and the absence of explicit frequency positional encoding. In this work, we propose a novel foundation model that integrates an advanced band-split architecture with relative frequency positional embeddings, enabling precise spectral localization across arbitrary sampling configurations. The model supports inputs of arbitrary length without padding or segmentation, producing a concise embedding that retains both temporal and spectral fidelity. We evaluate our method on SIREN (https://github.com/yucongzh/SIREN), a newly introduced large-scale benchmark for machine signal encoding that unifies multiple datasets, including all DCASE task 2 challenges (2020-2025) and widely-used industrial signal corpora. Experimental results demonstrate consistent state-of-the-art performance in anomaly detection and fault identification, confirming the effectiveness and generalization capability of the proposed model. We open-sourced ECHO on https://github.com/yucongzh/ECHO.

Existing foundation models, such as CLIP, aim to learn a unified embedding space for multimodal data, enabling a wide range of downstream web-based applications like search, recommendation, and content classification. However, these models often overlook the inherent graph structures in multimodal datasets, where entities and their relationships are crucial. Multimodal graphs (MMGs) represent such graphs where each node is associated with features from different modalities, while the edges capture the relationships between these entities. On the other hand, existing graph foundation models primarily focus on text-attributed graphs (TAGs) and are not designed to handle the complexities of MMGs. To address these limitations, we propose UniGraph2, a novel cross-domain graph foundation model that enables general representation learning on MMGs, providing a unified embedding space. UniGraph2 employs modality-specific encoders alongside a graph neural network (GNN) to learn a unified low-dimensional embedding space that captures both the multimodal information and the underlying graph structure. We propose a new cross-domain multi-graph pre-training algorithm at scale to ensure effective transfer learning across diverse graph domains and modalities. Additionally, we adopt a Mixture of Experts (MoE) component to align features from different domains and modalities, ensuring coherent and robust embeddings that unify the information across modalities. Extensive experiments on a variety of multimodal graph tasks demonstrate that UniGraph2 significantly outperforms state-of-the-art models in tasks such as representation learning, transfer learning, and multimodal generative tasks, offering a scalable and flexible solution for learning on MMGs.

LWM-Temporal is a new member of the Large Wireless Models (LWM) family that targets the spatiotemporal nature of wireless channels. Designed as a task-agnostic foundation model, LWM-Temporal learns universal channel embeddings that capture mobility-induced evolution and are reusable across various downstream tasks. To achieve this objective, LWM-Temporal operates in the angle-delay-time domain and introduces Sparse Spatio-Temporal Attention (SSTA), a propagation-aligned attention mechanism that restricts interactions to physically plausible neighborhoods, reducing attention complexity by an order of magnitude while preserving geometry-consistent dependencies. LWM-Temporal is pretrained in a self-supervised manner using a physics-informed masking curriculum that emulates realistic occlusions, pilot sparsity, and measurement impairments. Experimental results on channel prediction across multiple mobility regimes show consistent improvements over strong baselines, particularly under long horizons and limited fine-tuning data, highlighting the importance of geometry-aware architectures and geometry-consistent pretraining for learning transferable spatiotemporal wireless representations.

Small-molecule identification from tandem mass spectrometry (MS/MS) remains a bottleneck in untargeted settings where spectral libraries are incomplete. While deep learning offers a solution, current approaches typically fall into two extremes: explicit generative models that construct molecular graphs atom-by-atom, or joint contrastive models that learn cross-modal subspaces from scratch. We introduce SpecBridge, a novel implicit alignment framework that treats structure identification as a geometric alignment problem. SpecBridge fine-tunes a self-supervised spectral encoder (DreaMS) to project directly into the latent space of a frozen molecular foundation model (ChemBERTa), and then performs retrieval by cosine similarity to a fixed bank of precomputed molecular embeddings. Across MassSpecGym, Spectraverse, and MSnLib benchmarks, SpecBridge improves top-1 retrieval accuracy by roughly 20-25% relative to strong neural baselines, while keeping the number of trainable parameters small. These results suggest that aligning to frozen foundation models is a practical, stable alternative to designing new architectures from scratch. The code for SpecBridge is released at https://github.com/HassounLab/SpecBridge.

Building a unified visual tokenizer is essential for bridging the gap between visual understanding and generation. Yet existing approaches struggle with the inherent conflict between these tasks, as a single token space is forced to support both high-level semantic abstraction and low-level pixel reconstruction. We propose WinTok, a concise hybrid tokenizer that achieves a win-win performance by explicitly decoupling the two objectives. WinTok supplements pixel tokens with a set of learnable semantic tokens, effectively mitigating cross-task interference without incurring the computational overhead of dual tokenizers. To further enhance understanding capability, we introduce an asymmetric token distillation mechanism: the semantic tokens are guided by pretrained semantic embeddings from any visual foundation model, enabling them to inherit strong discriminative power while maintaining flexibility. Across 10 challenging benchmarks, WinTok delivers consistent improvements in reconstruction, understanding, and generation. Trained on only 50M open-source data, WinTok surpasses the strong baseline UniTok by 11.2% in classification accuracy and achieves a competitive reconstruction rFID of 0.41, despite using substantially less training data. Code is released at https://github.com/markywg/WinTok.

Finding scientifically interesting phenomena through slow, manual labeling campaigns severely limits our ability to explore the billions of galaxy images produced by telescopes. In this work, we develop a pipeline to create a semantic search engine from completely unlabeled image data. Our method leverages Vision-Language Models (VLMs) to generate descriptions for galaxy images, then contrastively aligns a pre-trained multimodal astronomy foundation model with these embedded descriptions to produce searchable embeddings at scale. We find that current VLMs provide descriptions that are sufficiently informative to train a semantic search model that outperforms direct image similarity search. Our model, AION-Search, achieves state-of-the-art zero-shot performance on finding rare phenomena despite training on randomly selected images with no deliberate curation for rare cases. Furthermore, we introduce a VLM-based re-ranking method that nearly doubles the recall for our most challenging targets in the top-100 results. For the first time, AION-Search enables flexible semantic search scalable to 140 million galaxy images, enabling discovery from previously infeasible searches. More broadly, our work provides an approach for making large, unlabeled scientific image archives semantically searchable, expanding data exploration capabilities in fields from Earth observation to microscopy. The code, data, and app are publicly available at https://github.com/NolanKoblischke/AION-Search

Foundation models have transformed vision and language processing by providing rich, reusable representations that transfer across diverse tasks. Sheet music, as a visual encoding of musical language, lacks such a strong domain-specific backbone. We introduce MuSViT (Music Score Vision Transformer): the first foundation vision model for sheet music representation -- a ViT encoder pre-trained via Masked Autoencoders on 9.7 million pages from the IMSLP. To handle the complexity of real-world scores, we adopt a two-stage curriculum: a synthetic warm-up on typeset scores followed by large-scale training on the full IMSLP corpus. We evaluate MuSViT on four downstream tasks -- full-page and staff-level music score recognition, music symbol detection, and score difficulty classification -- under two scenarios: linear probing (frozen encoder) and fine-tuning. Under linear probing, MuSViT consistently outperforms modern vision encoders, revealing that general-purpose representations, regardless of scale, fall systematically short on the structured symbolic properties of musical notation. Under fine-tuning, MuSViT generally improves upon task-specific state-of-the-art methods. An additional embedding-transcription consistency analysis reveals that MuSViT encodes symbolic musical structure directly in its representation space -- unlike other encoders, whose embeddings do not correlate with music notation content. These results establish MuSViT as a foundation backbone for sheet music understanding.

While deep learning has achieved remarkable success across many domains, it has historically underperformed on tabular learning tasks, which remain dominated by gradient boosting decision trees (GBDTs). However, recent advancements are paving the way for Tabular Foundation Models, which can leverage real-world knowledge and generalize across diverse datasets, particularly when the data contains free-text. Although incorporating language model capabilities into tabular tasks has been explored, most existing methods utilize static, target-agnostic textual representations, limiting their effectiveness. We introduce TabSTAR: a Foundation Tabular Model with Semantically Target-Aware Representations. TabSTAR is designed to enable transfer learning on tabular data with textual features, with an architecture free of dataset-specific parameters. It unfreezes a pretrained text encoder and takes as input target tokens, which provide the model with the context needed to learn task-specific embeddings. TabSTAR achieves state-of-the-art performance for both medium- and large-sized datasets across known benchmarks of classification tasks with text features, and its pretraining phase exhibits scaling laws in the number of datasets, offering a pathway for further performance improvements.

In this paper, we present a new embedding model, called M3-Embedding, which is distinguished for its versatility in Multi-Linguality, Multi-Functionality, and Multi-Granularity. It can support more than 100 working languages, leading to new state-of-the-art performances on multi-lingual and cross-lingual retrieval tasks. It can simultaneously perform the three common retrieval functionalities of embedding model: dense retrieval, multi-vector retrieval, and sparse retrieval, which provides a unified model foundation for real-world IR applications. It is able to process inputs of different granularities, spanning from short sentences to long documents of up to 8192 tokens. The effective training of M3-Embedding involves the following technical contributions. We propose a novel self-knowledge distillation approach, where the relevance scores from different retrieval functionalities can be integrated as the teacher signal to enhance the training quality. We also optimize the batching strategy, enabling a large batch size and high training throughput to ensure the discriminativeness of embeddings. To the best of our knowledge, M3-Embedding is the first embedding model which realizes such a strong versatility. The model and code will be publicly available at https://github.com/FlagOpen/FlagEmbedding.

This paper introduces RouteFinder, a comprehensive foundation model framework to tackle different Vehicle Routing Problem (VRP) variants. Our core idea is that a foundation model for VRPs should be able to represent variants by treating each as a subset of a generalized problem equipped with different attributes. We propose a unified VRP environment capable of efficiently handling any attribute combination. The RouteFinder model leverages a modern transformer-based encoder and global attribute embeddings to improve task representation. Additionally, we introduce two reinforcement learning techniques to enhance multi-task performance: mixed batch training, which enables training on different variants at once, and multi-variant reward normalization to balance different reward scales. Finally, we propose efficient adapter layers that enable fine-tuning for new variants with unseen attributes. Extensive experiments on 48 VRP variants show RouteFinder outperforms recent state-of-the-art learning methods. Code: https://github.com/ai4co/routefinder.

The open-vocabulary image segmentation task involves partitioning images into semantically meaningful segments and classifying them with flexible text-defined categories. The recent vision-based foundation models such as the Segment Anything Model (SAM) have shown superior performance in generating class-agnostic image segments. The main challenge in open-vocabulary image segmentation now lies in accurately classifying these segments into text-defined categories. In this paper, we introduce the Universal Segment Embedding (USE) framework to address this challenge. This framework is comprised of two key components: 1) a data pipeline designed to efficiently curate a large amount of segment-text pairs at various granularities, and 2) a universal segment embedding model that enables precise segment classification into a vast range of text-defined categories. The USE model can not only help open-vocabulary image segmentation but also facilitate other downstream tasks (e.g., querying and ranking). Through comprehensive experimental studies on semantic segmentation and part segmentation benchmarks, we demonstrate that the USE framework outperforms state-of-the-art open-vocabulary segmentation methods.

Identifying sitters in historical paintings is a key task for art historians, offering insight into their lives and how they chose to be seen. However, the process is often subjective and limited by the lack of data and stylistic variations. Automated facial recognition is capable of handling challenging conditions and can assist, but while traditional facial recognition models perform well on photographs, they struggle with paintings due to domain shift and high intra-class variation. Artistic factors such as style, skill, intent, and influence from other works further complicate recognition. In this work, we investigate the potential of foundation models to improve facial recognition in artworks. By fine-tuning foundation models and integrating their embeddings with those from conventional facial recognition networks, we demonstrate notable improvements over current state-of-the-art methods. Our results show that foundation models can bridge the gap where traditional methods are ineffective. Paper page at https://www.idiap.ch/paper/artface/

Vision-language-action (VLA) models have recently shown strong potential in enabling robots to follow language instructions and execute precise actions. However, most VLAs are built upon vision-language models pretrained solely on 2D data, which lack accurate spatial awareness and hinder their ability to operate in the 3D physical world. Existing solutions attempt to incorporate explicit 3D sensor inputs such as depth maps or point clouds, but these approaches face challenges due to sensor noise, hardware heterogeneity, and incomplete depth coverage in existing datasets. Alternative methods that estimate 3D cues from 2D images also suffer from the limited performance of depth estimators.We propose Spatial Forcing (SF), a simple yet effective alignment strategy that implicitly forces VLA models to develop spatial comprehension capabilities without relying on explicit 3D inputs or depth estimators. SF aligns intermediate visual embeddings of VLAs with geometric representations produced by pretrained 3D foundation models. By enforcing alignment at intermediate layers, SF guides VLAs to encode richer spatial representations that enhance action precision.Extensive experiments in simulation and real-world environments demonstrate that SF achieves state-of-the-art results, surpassing both 2D- and 3D-based VLAs. SF further accelerates training by up to 3.8x and improves data efficiency across diverse robotic tasks. Project page is at https://spatial-forcing.github.io/

We present an efficient method for adapting a monolingual Large Language Model (LLM) to another language, addressing challenges of catastrophic forgetting and tokenizer limitations. We focus this study on adapting Llama 2 to Arabic. Our two-stage approach begins with expanding the vocabulary and training only the embeddings matrix, followed by full model continual pre-training on a bilingual corpus. By continually pre-training on a mix of Arabic and English corpora, the model retains its proficiency in English while acquiring capabilities in Arabic. Our approach results in significant improvements in Arabic and slight enhancements in English, demonstrating cost-effective cross-lingual transfer. We perform ablations on embedding initialization techniques, data mix ratios, and learning rates and release a detailed training recipe. To demonstrate generalizability of this approach we also adapted Llama 3 8B to Arabic and Llama 2 13B to Hindi.

Large language models excel in many human-language tasks but often falter in highly specialized domains like scholarly astronomy. To bridge this gap, we introduce AstroLLaMA, a 7-billion-parameter model fine-tuned from LLaMA-2 using over 300,000 astronomy abstracts from arXiv. Optimized for traditional causal language modeling, AstroLLaMA achieves a 30% lower perplexity than Llama-2, showing marked domain adaptation. Our model generates more insightful and scientifically relevant text completions and embedding extraction than state-of-the-arts foundation models despite having significantly fewer parameters. AstroLLaMA serves as a robust, domain-specific model with broad fine-tuning potential. Its public release aims to spur astronomy-focused research, including automatic paper summarization and conversational agent development.

3D geometric information is essential for manipulation tasks, as robots need to perceive the 3D environment, reason about spatial relationships, and interact with intricate spatial configurations. Recent research has increasingly focused on the explicit extraction of 3D features, while still facing challenges such as the lack of large-scale robotic 3D data and the potential loss of spatial geometry. To address these limitations, we propose the Lift3D framework, which progressively enhances 2D foundation models with implicit and explicit 3D robotic representations to construct a robust 3D manipulation policy. Specifically, we first design a task-aware masked autoencoder that masks task-relevant affordance patches and reconstructs depth information, enhancing the 2D foundation model's implicit 3D robotic representation. After self-supervised fine-tuning, we introduce a 2D model-lifting strategy that establishes a positional mapping between the input 3D points and the positional embeddings of the 2D model. Based on the mapping, Lift3D utilizes the 2D foundation model to directly encode point cloud data, leveraging large-scale pretrained knowledge to construct explicit 3D robotic representations while minimizing spatial information loss. In experiments, Lift3D consistently outperforms previous state-of-the-art methods across several simulation benchmarks and real-world scenarios.

The electrocardiogram (ECG) is a cost-effective, highly accessible and widely employed diagnostic tool. With the advent of Foundation Models (FMs), the field of AI-assisted ECG interpretation has begun to evolve, as they enable model reuse across different tasks by relying on embeddings. However, to responsibly employ FMs, it is crucial to rigorously assess to which extent the embeddings they produce are generalizable, particularly in error-sensitive domains such as healthcare. Although prior works have already addressed the problem of benchmarking ECG-expert FMs, they focus predominantly on the evaluation of downstream performance. To fill this gap, this study aims to find an in-depth, comprehensive benchmarking framework for FMs, with a specific focus on ECG-expert ones. To this aim, we introduce a benchmark methodology that complements performance-based evaluation with representation-level analysis, leveraging SHAP and UMAP techniques. Furthermore, we rely on the methodology for carrying out an extensive evaluation of several ECG-expert FMs pretrained via state-of-the-art techniques over different cross-continental datasets and data availability settings; this includes ones featuring data scarcity, a fairly common situation in real-world medical scenarios. Experimental results show that our benchmarking protocol provides a rich insight of ECG-expert FMs' embedded patterns, enabling a deeper understanding of their representational structure and generalizability.

We study the data selection problem, whose aim is to select a small representative subset of data that can be used to efficiently train a machine learning model. We present a new data selection approach based on k-means clustering and sensitivity sampling. Assuming access to an embedding representation of the data with respect to which the model loss is H\"older continuous, our approach provably allows selecting a set of ``typical'' k + 1/varepsilon^2 elements whose average loss corresponds to the average loss of the whole dataset, up to a multiplicative (1pmvarepsilon) factor and an additive varepsilon lambda Phi_k, where Phi_k represents the k-means cost for the input embeddings and lambda is the H\"older constant. We furthermore demonstrate the performance and scalability of our approach on fine-tuning foundation models and show that it outperforms state-of-the-art methods. We also show how it can be applied on linear regression, leading to a new sampling strategy that surprisingly matches the performances of leverage score sampling, while being conceptually simpler and more scalable.

Vision language models (VLMs) have achieved remarkable success in broad visual understanding, yet they remain challenged by object-centric reasoning on rare objects due to the scarcity of such instances in pretraining data. While prior efforts alleviate this issue by retrieving additional data or introducing stronger vision encoders, these methods are still computationally intensive during finetuning VLMs and don't fully exploit the original training data. In this paper, we introduce an efficient plug-and-play module that substantially improves VLMs' reasoning over rare objects by refining visual tokens and enriching input text prompts, without VLMs finetuning. Specifically, we propose to learn multi-modal class embeddings for rare objects by leveraging prior knowledge from vision foundation models and synonym-augmented text descriptions, compensating for limited training examples. These embeddings refine the visual tokens in VLMs through a lightweight attention-based enhancement module that improves fine-grained object details. In addition, we use the learned embeddings as object-aware detectors to generate informative hints, which are injected into the text prompts to help guide the VLM's attention toward relevant image regions. Experiments on two benchmarks show consistent and substantial gains for pretrained VLMs in rare object recognition and reasoning. Further analysis reveals how our method strengthens the VLM's ability to focus on and reason about rare objects.

Time Series Foundation Models (TSFMs) excel at numerical forecasting but operate as black boxes lacking qualitative reasoning. Conversely, applying LLMs directly to temporal data introduces a modality gap: text tokenizers fragment continuous numerical values, degrading mathematical relationships and exploding sequence lengths, leading to computational overhead. To resolve this, we introduce STRIDE (Strategic Time-series Reasoning Injected via Distilled Embeddings), a novel framework natively integrating LLM reasoning into the continuous embedding space of TSFMs. Instead of discrete tokens, STRIDE distills reasoning traces into a lightweight LLM, dynamically projecting its mean-pooled hidden states as a cross-modal prior into the target numerical encoder. The architecture is jointly optimized using cross-entropy and quantile losses. Evaluations demonstrate STRIDE establishes state-of-the-art numerical forecasting on GIFT-Eval (0.674 MASE, 0.454 CRPS) compared to TSFMs and exhibits superior in-domain and out-of-domain numerical as well as reasoning performance on TFRBench. Specifically, STRIDE acts as a plug-and-play enhancement, consistently improving diverse TSFMs (e.g., Chronos-2, Timer-S1) across various LLM configurations. Thus, injecting semantic reasoning as a continuous prior equips TSFMs with human-interpretable reasoning while fundamentally improving predictive accuracy.

The prevailing paradigm for scaling large language models (LLMs) involves monolithic, end-to-end training, a resource-intensive process that lacks flexibility. This paper explores an alternative, constructive approach to model development, built upon the foundation of non-trainable, deterministic input embeddings. In prior [1], we established that high-level semantic reasoning can emerge in Transformers using frozen embeddings derived from the visual structure of Unicode glyphs. Here, we demonstrate that this fixed representational substrate acts as a universal "docking port," enabling two powerful and efficient scaling paradigms: seamless modular composition and progressive layer-wise growth. First, we show that specialist models trained on disparate datasets (e.g., Russian and Chinese text) can be merged into a single, more capable Mixture-of-Experts (MoE) model, post-training, with zero architectural modification. This is achieved by simply averaging their output logits. The resulting MoE model exhibits immediate performance improvements on reasoning benchmarks like MMLU, surpassing its constituent experts without catastrophic forgetting. Second, we introduce a layer-wise constructive training methodology, where a deep Transformer is "grown" by progressively stacking and training one layer at a time. This method demonstrates stable convergence and a clear correlation between model depth and the emergence of complex reasoning abilities, such as those required for SQuAD. Our findings suggest a paradigm shift from monolithic optimization towards a more biological or constructive model of AI development, where complexity is built incrementally and modules can be composed freely. This opens new avenues for resource-efficient scaling, continual learning, and a more democratized ecosystem for building powerful AI systems. We release all code and models to facilitate further research.

Team modeling remains a fundamental challenge at the intersection of Artificial Intelligence and the Social Sciences. Social Science research emphasizes the need to jointly model dynamics and relations, while practical applications demand unified models capable of inferring multiple team constructs simultaneously, providing interpretable insights and actionable recommendations to enhance team performance. However, existing works do not meet these practical demands. To bridge this gap, we present TRENN, a novel tempo-relational architecture that integrates: (i) an automatic temporal graph extractor, (ii) a tempo-relational encoder, (iii) a decoder for team construct prediction, and (iv) two complementary explainability modules. TRENN jointly captures relational and temporal team dynamics, providing a solid foundation for MT-TRENN, which extends TReNN by replacing the decoder with a multi-task head, enabling the model to learn shared Social Embeddings and simultaneously predict multiple team constructs, including Emergent Leadership, Leadership Style, and Teamwork components. Experimental results demonstrate that our approach significantly outperforms approaches that rely exclusively on temporal or relational information. Additionally, experimental evaluation has shown that the explainability modules integrated in MT-TRENN yield interpretable insights and actionable suggestions to support team improvement. These capabilities make our approach particularly well-suited for Human-Centered AI applications, such as intelligent decision-support systems in high-stakes collaborative environments.

Neurophysiological recordings such as electroencephalography (EEG) offer accessible and minimally invasive means of estimating physiological activity for applications in healthcare, diagnostic screening, and even immersive entertainment. However, these recordings yield high-dimensional, noisy time-series data that typically require extensive pre-processing and handcrafted feature extraction to reveal meaningful information. Recently, there has been a surge of interest in applying representation learning techniques from large pre-trained (foundation) models to effectively decode and interpret biosignals. We discuss the challenges posed for incorporating such methods and introduce BioCodec, an alternative representation learning framework inspired by neural codecs to capture low-level signal characteristics in the form of discrete tokens. Pre-trained on thousands of EEG hours, BioCodec shows efficacy across multiple downstream tasks, ranging from clinical diagnostic tasks and sleep physiology to decoding speech and motor imagery, particularly in low-resource settings. Additionally, we provide a qualitative analysis of codebook usage and estimate the spatial coherence of codebook embeddings from EEG connectivity. Notably, we also document the suitability of our method to other biosignal data, i.e., electromyographic (EMG) signals. Overall, the proposed approach provides a versatile solution for biosignal tokenization that performs competitively with state-of-the-art models. The source code and model checkpoints are shared.

We present RADIO-ViPE (Reduce All Domains Into One -- Video Pose Engine), an online semantic SLAM system that enables geometry-aware open-vocabulary grounding, associating arbitrary natural language queries with localized 3D regions and objects in dynamic environments. Unlike existing approaches that require calibrated, posed RGB-D input, RADIO-ViPE operates directly on raw monocular RGB video streams, requiring no prior camera intrinsics, depth sensors, or pose initialization. The system tightly couples multi-modal embeddings -- spanning vision and language -- derived from agglomerative foundation models (e.g., RADIO) with geometric scene information. This coupling takes place in initialization, optimization and factor graph connections to improve the consistency of the map from multiple modalities. The optimization is wrapped within adaptive robust kernels, designed to handle both actively moving objects and agent-displaced scene elements (e.g., furniture rearranged during ego-centric session). Experiments demonstrate that RADIO-ViPE achieves state-of-the-art results on the dynamic TUM-RGBD benchmark while maintaining competitive performance against offline open-vocabulary methods that rely on calibrated data and static scene assumptions. RADIO-ViPE bridges a critical gap in real-world deployment, enabling robust open-vocabulary semantic grounding for autonomous robotics and unconstrained in-the-wild video streams. Project page: https://be2rlab.github.io/radio_vipe

Vision foundation models like DINOv2 demonstrate remarkable potential in medical imaging despite their origin in natural image domains. However, their design inherently works best for uni-modal image analysis, limiting their effectiveness for multi-modal imaging tasks that are common in many medical fields, such as neurology and oncology. While supervised models perform well in this setting, they fail to leverage unlabeled datasets and struggle with missing modalities, a frequent challenge in clinical settings. To bridge these gaps, we introduce MM-DINOv2, a novel and efficient framework that adapts the pre-trained vision foundation model DINOv2 for multi-modal medical imaging. Our approach incorporates multi-modal patch embeddings, enabling vision foundation models to effectively process multi-modal imaging data. To address missing modalities, we employ full-modality masking, which encourages the model to learn robust cross-modality relationships. Furthermore, we leverage semi-supervised learning to harness large unlabeled datasets, enhancing both the accuracy and reliability of medical predictions. Applied to glioma subtype classification from multi-sequence brain MRI, our method achieves a Matthews Correlation Coefficient (MCC) of 0.6 on an external test set, surpassing state-of-the-art supervised approaches by +11.1%. Our work establishes a scalable and robust solution for multi-modal medical imaging tasks, leveraging powerful vision foundation models pre-trained on natural images while addressing real-world clinical challenges such as missing data and limited annotations.

We present NDAI-NeuroMAP, the first neuroscience-domain-specific dense vector embedding model engineered for high-precision information retrieval tasks. Our methodology encompasses the curation of an extensive domain-specific training corpus comprising 500,000 carefully constructed triplets (query-positive-negative configurations), augmented with 250,000 neuroscience-specific definitional entries and 250,000 structured knowledge-graph triplets derived from authoritative neurological ontologies. We employ a sophisticated fine-tuning approach utilizing the FremyCompany/BioLORD-2023 foundation model, implementing a multi-objective optimization framework combining contrastive learning with triplet-based metric learning paradigms. Comprehensive evaluation on a held-out test dataset comprising approximately 24,000 neuroscience-specific queries demonstrates substantial performance improvements over state-of-the-art general-purpose and biomedical embedding models. These empirical findings underscore the critical importance of domain-specific embedding architectures for neuroscience-oriented RAG systems and related clinical natural language processing applications.

In this work, we present MedImageInsight, an open-source medical imaging embedding model. MedImageInsight is trained on medical images with associated text and labels across a diverse collection of domains, including X-Ray, CT, MRI, dermoscopy, OCT, fundus photography, ultrasound, histopathology, and mammography. Rigorous evaluations demonstrate MedImageInsight's ability to achieve state-of-the-art (SOTA) or human expert level performance across classification, image-image search, and fine-tuning tasks. Specifically, on public datasets, MedImageInsight achieves SOTA in CT 3D medical image retrieval, as well as SOTA in disease classification and search for chest X-ray, dermatology, and OCT imaging. Furthermore, MedImageInsight achieves human expert performance in bone age estimation (on both public and partner data), as well as AUC above 0.9 in most other domains. When paired with a text decoder, MedImageInsight achieves near SOTA level single image report findings generation with less than 10\% the parameters of other models. Compared to fine-tuning GPT-4o with only MIMIC-CXR data for the same task, MedImageInsight outperforms in clinical metrics, but underperforms on lexical metrics where GPT-4o sets a new SOTA. Importantly for regulatory purposes, MedImageInsight can generate ROC curves, adjust sensitivity and specificity based on clinical need, and provide evidence-based decision support through image-image search (which can also enable retrieval augmented generation). In an independent clinical evaluation of image-image search in chest X-ray, MedImageInsight outperformed every other publicly available foundation model evaluated by large margins (over 6 points AUC), and significantly outperformed other models in terms of AI fairness (across age and gender). We hope releasing MedImageInsight will help enhance collective progress in medical imaging AI research and development.

Cross-modal embeddings form the foundation for multi-modal models. However, visualization methods for interpreting cross-modal embeddings have been primarily confined to traditional dimensionality reduction (DR) techniques like PCA and t-SNE. These DR methods primarily focus on feature distributions within a single modality, whilst failing to incorporate metrics (e.g., CLIPScore) across multiple modalities. This paper introduces AKRMap, a new DR technique designed to visualize cross-modal embeddings metric with enhanced accuracy by learning kernel regression of the metric landscape in the projection space. Specifically, AKRMap constructs a supervised projection network guided by a post-projection kernel regression loss, and employs adaptive generalized kernels that can be jointly optimized with the projection. This approach enables AKRMap to efficiently generate visualizations that capture complex metric distributions, while also supporting interactive features such as zoom and overlay for deeper exploration. Quantitative experiments demonstrate that AKRMap outperforms existing DR methods in generating more accurate and trustworthy visualizations. We further showcase the effectiveness of AKRMap in visualizing and comparing cross-modal embeddings for text-to-image models. Code and demo are available at https://github.com/yilinye/AKRMap.

Time series foundation models (TSFMs) offer strong zero-shot forecasting via large-scale pre-training, yet fine-tuning remains critical for boosting performance in domains with limited public data. With the growing number of TSFMs, efficiently identifying the best model for downstream fine-tuning becomes increasingly challenging. In this work, we introduce TimeTic, a transferability estimation framework that recasts model selection as an in-context-learning problem: given observations on known (source) datasets, it predicts how a TSFM will perform after fine-tuning on a downstream (target) dataset. TimeTic flexibly organizes the observed model-data relationships as contextual information, allowing it to adapt seamlessly to various test-time scenarios. Leveraging the natural tabular structure formed by dataset meta-features, model characteristics, and fine-tuned performance, we employ tabular foundation models to serve as in-context learners. We further introduce a novel model characterization based on entropy evolution across model layers, capturing embedding-space distinctions and enabling TimeTic to generalize across arbitrary model sets. We establish a comprehensive benchmark for transferability estimation including 10 datasets, 10 foundation models, and 3 forecasting tasks. On this benchmark, TimeTic's estimation demonstrates strong alignment with actual fine-tuned performance for previously unseen datasets, achieving a mean rank correlation of approximately 0.6 and a 30% improvement compared to using zero-shot performance as the transferability score.

Conventional urban indicators derived from censuses, surveys, and administrative records are often costly, spatially inconsistent, and slow to update. Recent geospatial foundation models enable Earth embeddings, compact satellite image representations transferable across downstream tasks, but their utility for neighborhood-scale urban monitoring remains unclear. Here, we benchmark three Earth embedding families, AlphaEarth, Prithvi, and Clay, for urban signal prediction across six U.S. metropolitan areas from 2020 to 2023. Using a unified supervised-learning framework, we predict 14 neighborhood-level indicators spanning crime, income, health, and travel behavior, and evaluate performance under four settings: global, city-wise, year-wise, and city-year. Results show that Earth embeddings capture substantial urban variation, with the highest predictive skill for outcomes more directly tied to built-environment structure, including chronic health burdens and dominant commuting modes. By contrast, indicators shaped more strongly by fine-scale behavior and local policy, such as cycling, remain difficult to infer. Predictive performance varies markedly across cities but remains comparatively stable across years, indicating strong spatial heterogeneity alongside temporal robustness. Exploratory analysis suggests that cross-city variation in predictive performance is associated with urban form in task-specific ways. Controlled dimensionality experiments show that representation efficiency is critical: compact 64-dimensional AlphaEarth embeddings remain more informative than 64-dimensional reductions of Prithvi and Clay. This study establishes a benchmark for evaluating Earth embeddings in urban remote sensing and demonstrates their potential as scalable, low-cost features for SDG-aligned neighborhood-scale urban monitoring.

User representation modeling has become increasingly crucial for personalized applications, yet existing approaches struggle with generalizability across domains and sensitivity to noisy behavioral signals. We present InstructUE, an instruction-aware user embedding foundation model that leverages large language models (LLMs) to generate general and instruction-aware user representations. InstructUE introduces a multi-encoder architecture with a lightweight adapter that efficiently processes heterogeneous data from six different sources while preserving their structural characteristics. Additionally, it proposes a novel contrastive-autoregressive training framework that bridges language and representation spaces through a curated UserQA dataset. The contrastive-autoregressive training framework simultaneously leverages autoregressive learning to capture domain knowledge in language space and contrastive learning to align user-text embeddings in representation space, thereby enhancing the instruction-awareness and noise-robustness of user embeddings. Through extensive experiments on real-world applications, we demonstrate that InstructUE significantly outperforms existing methods across multiple domains including user prediction, marketing, and recommendation scenarios. Our results show that instruction-aware user modeling can effectively achieve instruction-guided denoising of user information in specific scenarios, paving the way for more generalizable and robust user representation learning.

Self-supervised visual foundation models produce powerful embeddings that achieve remarkable performance on a wide range of downstream tasks. However, unlike vision-language models such as CLIP, self-supervised visual features are not readily aligned with language, hindering their adoption in open-vocabulary tasks. Our method, named dino.txt, unlocks this new ability for DINOv2, a widely used self-supervised visual encoder. We build upon the LiT training strategy, which trains a text encoder to align with a frozen vision model but leads to unsatisfactory results on dense tasks. We propose several key ingredients to improve performance on both global and dense tasks, such as concatenating the [CLS] token with the patch average to train the alignment and curating data using both text and image modalities. With these, we successfully train a CLIP-like model with only a fraction of the computational cost compared to CLIP while achieving state-of-the-art results in zero-shot classification and open-vocabulary semantic segmentation.

Multiple instance learning (MIL) is the most widely used framework in computational pathology, encompassing sub-typing, diagnosis, prognosis, and more. However, the existing MIL paradigm typically requires an offline instance feature extractor, such as a pre-trained ResNet or a foundation model. This approach lacks the capability for feature fine-tuning within the specific downstream tasks, limiting its adaptability and performance. To address this issue, we propose a Re-embedded Regional Transformer (R^2T) for re-embedding the instance features online, which captures fine-grained local features and establishes connections across different regions. Unlike existing works that focus on pre-training powerful feature extractor or designing sophisticated instance aggregator, R^2T is tailored to re-embed instance features online. It serves as a portable module that can seamlessly integrate into mainstream MIL models. Extensive experimental results on common computational pathology tasks validate that: 1) feature re-embedding improves the performance of MIL models based on ResNet-50 features to the level of foundation model features, and further enhances the performance of foundation model features; 2) the R^2T can introduce more significant performance improvements to various MIL models; 3) R^2T-MIL, as an R^2T-enhanced AB-MIL, outperforms other latest methods by a large margin.The code is available at: https://github.com/DearCaat/RRT-MIL.

Graph Foundation Models (GFMs) have achieved remarkable success in generalizing across diverse domains. However, they mainly focus on Text-Attributed Graphs (TAGs), leaving Multimodal-Attributed Graphs (MAGs) largely untapped. Developing Multimodal Graph Foundation Models (MGFMs) allows for leveraging the rich multimodal information in MAGs, and extends applicability to broader types of downstream tasks. While recent MGFMs integrate diverse modality information, our empirical investigation reveals two fundamental limitations of existing MGFMs: (1)they fail to explicitly model modality interaction, essential for capturing intricate cross-modal semantics beyond simple aggregation, and (2)they exhibit sub-optimal modality alignment, which is critical for bridging the significant semantic disparity between distinct modal spaces. To address these challenges, we propose PLANET (graPh topoLogy-aware modAlity iNteraction and alignmEnT), a novel framework employing a Divide-and-Conquer strategy to decouple modality interaction and alignment across distinct granularities. At the embedding granularity, (1)Embedding-wise Domain Gating (EDG) performs local semantic enrichment by adaptively infusing topology-aware cross-modal context, achieving modality interaction. At the node granularity, (2)Node-wise Discretization Retrieval (NDR) ensures global modality alignment by constructing a Discretized Semantic Representation Space (DSRS) to bridge modality gaps. Extensive experiments demonstrate that PLANET significantly outperforms state-of-the-art baselines across diverse graph-centric and multimodal generative tasks.

Bumblebee is a foundation model for particle physics discovery, inspired by BERT. By removing positional encodings and embedding particle 4-vectors, Bumblebee captures both generator- and reconstruction-level information while ensuring sequence-order invariance. Pre-trained on a masked task, it improves dileptonic top quark reconstruction resolution by 10-20% and excels in downstream tasks, including toponium discrimination (AUROC 0.877) and initial state classification (AUROC 0.625). The flexibility of Bumblebee makes it suitable for a wide range of particle physics applications, especially the discovery of new particles.

This work addresses a fundamental barrier in recommender systems: the inability to generalize across domains without extensive retraining. Traditional ID-based approaches fail entirely in cold-start and cross-domain scenarios where new users or items lack sufficient interaction history. Inspired by foundation models' cross-domain success, we develop a foundation model for sequential recommendation that achieves genuine zero-shot generalization capabilities. Our approach fundamentally departs from existing ID-based methods by deriving item representations exclusively from textual features. This enables immediate embedding of any new item without model retraining. We introduce unified item tokenization with Finite Scalar Quantization that transforms heterogeneous textual descriptions into standardized discrete tokens. This eliminates domain barriers that plague existing systems. Additionally, the framework features hybrid bidirectional-causal attention that captures both intra-item token coherence and inter-item sequential dependencies. An efficient catalog-aware beam search decoder enables real-time token-to-item mapping. Unlike conventional approaches confined to their training domains, RecGPT naturally bridges diverse recommendation contexts through its domain-invariant tokenization mechanism. Comprehensive evaluations across six datasets and industrial scenarios demonstrate consistent performance advantages.

Multi-modal foundation models like OpenFlamingo, LLaVA, and GPT-4 are increasingly used for various real-world tasks. Prior work has shown that these models are highly vulnerable to adversarial attacks on the vision modality. These attacks can be leveraged to spread fake information or defraud users, and thus pose a significant risk, which makes the robustness of large multi-modal foundation models a pressing problem. The CLIP model, or one of its variants, is used as a frozen vision encoder in many vision-language models (VLMs), e.g. LLaVA and OpenFlamingo. We propose an unsupervised adversarial fine-tuning scheme to obtain a robust CLIP vision encoder, which yields robustness on all vision down-stream tasks (VLMs, zero-shot classification) that rely on CLIP. In particular, we show that stealth-attacks on users of VLMs by a malicious third party providing manipulated images are no longer possible once one replaces the original CLIP model with our robust one. No retraining or fine-tuning of the VLM is required. The code and robust models are available at https://github.com/chs20/RobustVLM

While foundation models have advanced surgical video analysis, current approaches rely predominantly on pixel-level reconstruction objectives that waste model capacity on low-level visual details - such as smoke, specular reflections, and fluid motion - rather than semantic structures essential for surgical understanding. We present UniSurg, a video-native foundation model that shifts the learning paradigm from pixel-level reconstruction to latent motion prediction. Built on the Video Joint Embedding Predictive Architecture (V-JEPA), UniSurg introduces three key technical innovations tailored to surgical videos: 1) motion-guided latent prediction to prioritize semantically meaningful regions, 2) spatiotemporal affinity self-distillation to enforce relational consistency, and 3) feature diversity regularization to prevent representation collapse in texture-sparse surgical scenes. To enable large-scale pretraining, we curate UniSurg-15M, the largest surgical video dataset to date, comprising 3,658 hours of video from 50 sources across 13 anatomical regions. Extensive experiments across 17 benchmarks demonstrate that UniSurg significantly outperforms state-of-the-art methods on surgical workflow recognition (+14.6% F1 on EgoSurgery, +10.3% on PitVis), action triplet recognition (39.54% mAP-IVT on CholecT50), skill assessment, polyp segmentation, and depth estimation. These results establish UniSurg as a new standard for universal, motion-oriented surgical video understanding.

In order to make the foundation model more efficient and effective, our idea is combining sequence transformation and state transformation. First, we prove the availability of rotary position embedding in the state space duality algorithm, which reduces the perplexity of the hybrid quadratic causal self-attention and state space duality by more than 4%, to ensure that the combining sequence transformation unifies position encoding. Second, we propose dynamic mask attention, which maintains 100% accuracy in the more challenging multi-query associative recall task, improving by more than 150% compared to quadratic causal self-attention and state space duality, to ensure that the combining sequence transformation selectively filters relevant information. Third, we design cross domain mixture of experts, which makes the computational speed of expert retrieval with more than 1024 experts 8 to 10 times faster than the mixture of experts, to ensure that the combining state transformation quickly retrieval mixture. Finally, we summarize these matrix algorithms that can form the foundation model: Wonderful Matrices, which can be a competitor to popular model architectures.

Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature". While effective at capturing local syntax, these generative paradigms prioritize token-level reconstruction over high-level functional context. We introduce JEPA-DNA, a model-agnostic continual training framework that integrates a Joint-Embedding Predictive Architecture (JEPA) with traditional generative objectives. By supervising global sequence embeddings in a latent space, JEPA-DNA forces models to predict the functional representations of masked genomic segments, shifting the learning signal from token recovery to semantic alignment. We evaluate JEPA-DNA on 17 diverse genomic benchmark tasks, demonstrating consistent gains in linear probing and zero-shot performance regardless of the underlying GFM architecture or generative objective. Our framework establishes a new state-of-the-art for GFMs, surpassing the best existing models by bridging generative precision with latent semantic grounding. Through extensive ablation studies, we further characterize the synergistic interplay between generative and latent objectives. Our code is publicly available at https://github.com/NVIDIA-Digital-Bio/JEPA-DNA.

Retinal foundation models have significantly advanced retinal image analysis by leveraging self-supervised learning to reduce dependence on labeled data while achieving strong generalization. Many recent approaches enhance retinal image understanding using report supervision, but obtaining clinical reports is often costly and challenging. In contrast, metadata (e.g., age, gender) is widely available and serves as a valuable resource for analyzing disease progression. To effectively incorporate patient-specific information, we propose PRETI, a retinal foundation model that integrates metadata-aware learning with robust self-supervised representation learning. We introduce Learnable Metadata Embedding (LME), which dynamically refines metadata representations. Additionally, we construct patient-level data pairs, associating images from the same individual to improve robustness against non-clinical variations. To further optimize retinal image representation, we propose Retina-Aware Adaptive Masking (RAAM), a strategy that selectively applies masking within the retinal region and dynamically adjusts the masking ratio during training. PRETI captures both global structures and fine-grained pathological details, resulting in superior diagnostic performance. Extensive experiments demonstrate that PRETI achieves state-of-the-art results across diverse diseases and biomarker predictions using in-house and public data, indicating the importance of metadata-guided foundation models in retinal disease analysis. Our code and pretrained model are available at https://github.com/MICV-yonsei/PRETI

Healthcare foundation models have largely followed paradigms from natural language processing and computer vision, emphasizing large scale pretraining and deterministic representations over heterogeneous clinical data. However, clinical observations are inherently incomplete, reflecting sparse, irregular, and modality dependent measurements of an underlying physiologic state. In this work, we propose a framework for uncertainty aware foundation modeling that represents each patient not as a point embedding, but as a distribution over plausible latent states. By learning set valued representations and enforcing consistency across partial views of the same patient, the model captures what is invariantly inferable while explicitly encoding epistemic uncertainty. We integrate this formulation with multimodal encoders and scalable self supervised objectives, combining reconstruction, contrastive alignment, and distributional regularization. Across diverse clinical tasks, our approach improves predictive performance, robustness under missing data, and uncertainty calibration relative to strong baselines. These results suggest that modeling what is not observed rather than only what is constitutes a critical inductive bias for healthcare foundation models.

Purpose: Surgical workflow analysis is crucial for improving surgical efficiency and safety. However, previous studies rely heavily on large-scale annotated datasets, posing challenges in cost, scalability, and reliance on expert annotations. To address this, we propose Surg-FTDA (Few-shot Text-driven Adaptation), designed to handle various surgical workflow analysis tasks with minimal paired image-label data. Methods: Our approach has two key components. First, Few-shot selection-based modality alignment selects a small subset of images and aligns their embeddings with text embeddings from the downstream task, bridging the modality gap. Second, Text-driven adaptation leverages only text data to train a decoder, eliminating the need for paired image-text data. This decoder is then applied to aligned image embeddings, enabling image-related tasks without explicit image-text pairs. Results: We evaluate our approach to generative tasks (image captioning) and discriminative tasks (triplet recognition and phase recognition). Results show that Surg-FTDA outperforms baselines and generalizes well across downstream tasks. Conclusion: We propose a text-driven adaptation approach that mitigates the modality gap and handles multiple downstream tasks in surgical workflow analysis, with minimal reliance on large annotated datasets. The code and dataset will be released in https://github.com/CAMMA-public/Surg-FTDA

This open access book provides a comprehensive overview of the state of the art in research and applications of Foundation Models and is intended for readers familiar with basic Natural Language Processing (NLP) concepts. Over the recent years, a revolutionary new paradigm has been developed for training models for NLP. These models are first pre-trained on large collections of text documents to acquire general syntactic knowledge and semantic information. Then, they are fine-tuned for specific tasks, which they can often solve with superhuman accuracy. When the models are large enough, they can be instructed by prompts to solve new tasks without any fine-tuning. Moreover, they can be applied to a wide range of different media and problem domains, ranging from image and video processing to robot control learning. Because they provide a blueprint for solving many tasks in artificial intelligence, they have been called Foundation Models. After a brief introduction to basic NLP models the main pre-trained language models BERT, GPT and sequence-to-sequence transformer are described, as well as the concepts of self-attention and context-sensitive embedding. Then, different approaches to improving these models are discussed, such as expanding the pre-training criteria, increasing the length of input texts, or including extra knowledge. An overview of the best-performing models for about twenty application areas is then presented, e.g., question answering, translation, story generation, dialog systems, generating images from text, etc. For each application area, the strengths and weaknesses of current models are discussed, and an outlook on further developments is given. In addition, links are provided to freely available program code. A concluding chapter summarizes the economic opportunities, mitigation of risks, and potential developments of AI.

Time Series Foundation Models (TSFMs) have shown significant impact through their model capacity, scalability, and zero-shot generalization. However, due to the heterogeneity of inter-variate dependencies and the backbone scalability on large-scale multivariate datasets, most TSFMs are typically pre-trained on univariate time series. This limitation renders them oblivious to crucial information from diverse covariates in real-world forecasting tasks. To further enhance the performance of TSFMs, we propose a general covariate-aware adaptation (CoRA) framework for TSFMs. It leverages pre-trained backbones of foundation models while effectively incorporating exogenous covariates from various modalities, including time series, language, and images, to improve the quality of predictions. Technically, CoRA maintains the equivalence of initialization and parameter consistency during adaptation. With preserved backbones of foundation models as frozen feature extractors, the outcome embeddings from foundation models are empirically demonstrated more informative than raw data. Further, CoRA employs a novel Granger Causality Embedding (GCE) to automatically evaluate covariates regarding their causal predictability with respect to the target variate. We incorporate these weighted embeddings with a zero-initialized condition-injection mechanism, avoiding catastrophic forgetting of pre-trained foundation models and gradually integrates exogenous information. Extensive experiments show that CoRA of TSFMs surpasses state-of-the-art covariate-aware deep forecasters with full or few-shot training samples, achieving 31.1% MSE reduction on covariate-aware forecasting. Compared to other adaptation methods, CoRA exhibits strong compatibility with various advanced TSFMs and extends the scope of covariates to other modalities, presenting a practical paradigm for the application of TSFMs.

Electricity price forecasting in Europe presents unique challenges due to the continent's increasingly integrated and physically interconnected power market. While recent advances in foundation models have led to substantial improvements in general time series forecasting, most existing approaches do not incorporate prior graph knowledge from the transmission topology, which can limit their ability to exploit meaningful cross-region dependencies in interconnected power systems, motivating a domain-specific foundation model. In this paper, we address this gap by first introducing a comprehensive and up-to-date dataset across 24 European countries (38 regions), spanning from 2022-01-01 to 2026-01-01. Building on this groundwork, we propose PriceFM, a probabilistic foundation model pretrained on this large dataset. Specifically, PriceFM maps each region's price and exogenous features into a comparable latent embedding via a shared Mixture-of-Experts (MoE) projection layer, then injects prior graph knowledge by constructing a sparse graph mask derived from transmission topology. Across a large-scale European benchmark, PriceFM achieves strong performance and demonstrates superior generalization under both zero-shot and full-shot evaluation compared with multiple competitive baselines.

Foundation models (FMs) have shown transformative potential in radiology by performing diverse, complex tasks across imaging modalities. Here, we developed CT-FM, a large-scale 3D image-based pre-trained model designed explicitly for various radiological tasks. CT-FM was pre-trained using 148,000 computed tomography (CT) scans from the Imaging Data Commons through label-agnostic contrastive learning. We evaluated CT-FM across four categories of tasks, namely, whole-body and tumor segmentation, head CT triage, medical image retrieval, and semantic understanding, showing superior performance against state-of-the-art models. Beyond quantitative success, CT-FM demonstrated the ability to cluster regions anatomically and identify similar anatomical and structural concepts across scans. Furthermore, it remained robust across test-retest settings and indicated reasonable salient regions attached to its embeddings. This study demonstrates the value of large-scale medical imaging foundation models and by open-sourcing the model weights, code, and data, aims to support more adaptable, reliable, and interpretable AI solutions in radiology.

Online advertising relies on accurate recommendation models, with recent advances using pre-trained large-scale foundation models (LFMs) to capture users' general interests across multiple scenarios and tasks. However, existing methods have critical limitations: they extract and transfer only user representations (URs), ignoring valuable item representations (IRs) and user-item cross representations (CRs); and they simply use a UR as a feature in downstream applications, which fails to bridge upstream-downstream gaps and overlooks more transfer granularities. In this paper, we propose LFM4Ads, an All-Representation Multi-Granularity transfer framework for ads recommendation. It first comprehensively transfers URs, IRs, and CRs, i.e., all available representations in the pre-trained foundation model. To effectively utilize the CRs, it identifies the optimal extraction layer and aggregates them into transferable coarse-grained forms. Furthermore, we enhance the transferability via multi-granularity mechanisms: non-linear adapters for feature-level transfer, an Isomorphic Interaction Module for module-level transfer, and Standalone Retrieval for model-level transfer. LFM4Ads has been successfully deployed in Tencent's industrial-scale advertising platform, processing tens of billions of daily samples while maintaining terabyte-scale model parameters with billions of sparse embedding keys across approximately two thousand features. Since its production deployment in Q4 2024, LFM4Ads has achieved 10+ successful production launches across various advertising scenarios, including primary ones like Weixin Moments and Channels. These launches achieve an overall GMV lift of 2.45% across the entire platform, translating to estimated annual revenue increases in the hundreds of millions of dollars.

We present AstroCLIP, a strategy to facilitate the construction of astronomical foundation models that bridge the gap between diverse observational modalities. We demonstrate that a cross-modal contrastive learning approach between images and optical spectra of galaxies yields highly informative embeddings of both modalities. In particular, we apply our method on multi-band images and optical spectra from the Dark Energy Spectroscopic Instrument (DESI), and show that: (1) these embeddings are well-aligned between modalities and can be used for accurate cross-modal searches, and (2) these embeddings encode valuable physical information about the galaxies -- in particular redshift and stellar mass -- that can be used to achieve competitive zero- and few- shot predictions without further finetuning. Additionally, in the process of developing our approach, we also construct a novel, transformer-based model and pretraining approach for processing galaxy spectra.

Exploring large-scale pretrained foundation models is of significant interest in computer vision because these models can be quickly transferred to many downstream tasks. This paper presents Contrastive Captioner (CoCa), a minimalist design to pretrain an image-text encoder-decoder foundation model jointly with contrastive loss and captioning loss, thereby subsuming model capabilities from contrastive approaches like CLIP and generative methods like SimVLM. In contrast to standard encoder-decoder transformers where all decoder layers attend to encoder outputs, CoCa omits cross-attention in the first half of decoder layers to encode unimodal text representations, and cascades the remaining decoder layers which cross-attend to the image encoder for multimodal image-text representations. We apply a contrastive loss between unimodal image and text embeddings, in addition to a captioning loss on the multimodal decoder outputs which predicts text tokens autoregressively. By sharing the same computational graph, the two training objectives are computed efficiently with minimal overhead. CoCa is pretrained end-to-end and from scratch on both web-scale alt-text data and annotated images by treating all labels simply as text, seamlessly unifying natural language supervision for representation learning. Empirically, CoCa achieves state-of-the-art performance with zero-shot transfer or minimal task-specific adaptation on a broad range of downstream tasks, spanning visual recognition (ImageNet, Kinetics-400/600/700, Moments-in-Time), crossmodal retrieval (MSCOCO, Flickr30K, MSR-VTT), multimodal understanding (VQA, SNLI-VE, NLVR2), and image captioning (MSCOCO, NoCaps). Notably on ImageNet classification, CoCa obtains 86.3% zero-shot top-1 accuracy, 90.6% with a frozen encoder and learned classification head, and new state-of-the-art 91.0% top-1 accuracy on ImageNet with a finetuned encoder.

We introduce Brain-JEPA, a brain dynamics foundation model with the Joint-Embedding Predictive Architecture (JEPA). This pioneering model achieves state-of-the-art performance in demographic prediction, disease diagnosis/prognosis, and trait prediction through fine-tuning. Furthermore, it excels in off-the-shelf evaluations (e.g., linear probing) and demonstrates superior generalizability across different ethnic groups, surpassing the previous large model for brain activity significantly. Brain-JEPA incorporates two innovative techniques: Brain Gradient Positioning and Spatiotemporal Masking. Brain Gradient Positioning introduces a functional coordinate system for brain functional parcellation, enhancing the positional encoding of different Regions of Interest (ROIs). Spatiotemporal Masking, tailored to the unique characteristics of fMRI data, addresses the challenge of heterogeneous time-series patches. These methodologies enhance model performance and advance our understanding of the neural circuits underlying cognition. Overall, Brain-JEPA is paving the way to address pivotal questions of building brain functional coordinate system and masking brain activity at the AI-neuroscience interface, and setting a potentially new paradigm in brain activity analysis through downstream adaptation.

We pretrain METAGENE-1, a 7-billion-parameter autoregressive transformer model, which we refer to as a metagenomic foundation model, on a novel corpus of diverse metagenomic DNA and RNA sequences comprising over 1.5 trillion base pairs. This dataset is sourced from a large collection of human wastewater samples, processed and sequenced using deep metagenomic (next-generation) sequencing methods. Unlike genomic models that focus on individual genomes or curated sets of specific species, the aim of METAGENE-1 is to capture the full distribution of genomic information present within this wastewater, to aid in tasks relevant to pandemic monitoring and pathogen detection. We carry out byte-pair encoding (BPE) tokenization on our dataset, tailored for metagenomic sequences, and then pretrain our model. In this paper, we first detail the pretraining dataset, tokenization strategy, and model architecture, highlighting the considerations and design choices that enable the effective modeling of metagenomic data. We then show results of pretraining this model on our metagenomic dataset, providing details about our losses, system metrics, and training stability over the course of pretraining. Finally, we demonstrate the performance of METAGENE-1, which achieves state-of-the-art results on a set of genomic benchmarks and new evaluations focused on human-pathogen detection and genomic sequence embedding, showcasing its potential for public health applications in pandemic monitoring, biosurveillance, and early detection of emerging health threats.

Active computer vision promises efficient, biologically plausible perception through sequential, localized glimpses, but lacks scalable general-purpose architectures and pretraining pipelines. As a result, Active-Vision Foundation Models (AVFMs) have remained unexplored. We introduce CanViT, the first task- and policy-agnostic AVFM. CanViT uses scene-relative RoPE to bind a retinotopic Vision Transformer backbone and a spatiotopic scene-wide latent workspace, the canvas. Efficient interaction with this high-capacity working memory is supported by Canvas Attention, a novel asymmetric cross-attention mechanism. We decouple thinking (backbone-level) and memory (canvas-level), eliminating canvas-side self-attention and fully-connected layers to achieve low-latency sequential inference and scalability to large scenes. We propose a label-free active vision pretraining scheme, policy-agnostic passive-to-active dense latent distillation: reconstructing scene-wide DINOv3 embeddings from sequences of low-resolution glimpses with randomized locations, zoom levels, and lengths. We pretrain CanViT-B from a random initialization on 13.2 million ImageNet-21k scenes -- an order of magnitude more than previous active models -- and 1 billion random glimpses, in 166 hours on a single H100. On ADE20K segmentation, a frozen CanViT-B achieves 38.5% mIoU in a single low-resolution glimpse, outperforming the best active model's 27.6% with 19.5x fewer inference FLOPs and no fine-tuning, as well as its FLOP- or input-matched DINOv3 teacher. Given additional glimpses, CanViT-B reaches 45.9% ADE20K mIoU. On ImageNet-1k classification, CanViT-B reaches 81.2% top-1 accuracy with frozen teacher probes. CanViT generalizes to longer rollouts, larger scenes, and new policies. Our work closes the wide gap between passive and active vision on semantic segmentation and demonstrates the potential of AVFMs as a new research axis.

Accent variability remains a major errors in automatic speech recognition, yet most adaptation methods rely on parameter fine-tuning without understanding where accent information is encoded. We treat accent variation as an interpretable subspace in hidden representations and investigate whether it can be identified and controlled directly in activation space. We extract layer-wise encoder activations and estimate mean-shift directions capturing accent-induced representation shifts. By injecting these directions into individual layers and measuring how they align accented and standard embeddings, we derive a layer-wise accent sensitivity profile, revealing that accent information concentrates in a narrow band of middle encoder layers. Leveraging this structure, we further introduce parameter-free accent steering that modifies representations during inference without updating model weights. Experiments across eight accents show consistent word error rate reductions.

Existing foundation models (FMs) in the medical domain often require extensive fine-tuning or rely on training resource-intensive decoders, while many existing encoders are pretrained with objectives biased toward specific tasks. This illustrates a need for a strong, task-agnostic foundation model that requires minimal fine-tuning beyond feature extraction. In this work, we introduce a suite of task-agnostic pretraining of CT foundation models (TAP-CT): a simple yet effective adaptation of Vision Transformers (ViTs) and DINOv2 for volumetric data, enabling scalable self-supervised pretraining directly on 3D CT volumes. Our approach incorporates targeted modifications to patch embeddings, positional encodings, and volumetric augmentations, making the architecture depth-aware while preserving the simplicity of the underlying architectures. We show that large-scale 3D pretraining on an extensive in-house CT dataset (105K volumes) yields stable, robust frozen representations that generalize strongly across downstream tasks. To promote transparency and reproducibility, and to establish a powerful, low-resource baseline for future research in medical imaging, we will release all pretrained models, experimental configurations, and downstream benchmark code at https://huggingface.co/fomofo/tap-ct-b-3d.

The recent success of large foundation models in artificial intelligence has prompted the emergence of chemical pre-trained models. Despite the growing interest in large molecular pre-trained models that provide informative representations for downstream tasks, attempts for multimodal pre-training approaches on the molecule domain were limited. To address this, we present a novel multimodal molecular pre-trained model that incorporates the modalities of structure and biochemical properties, drawing inspiration from recent advances in multimodal learning techniques. Our proposed model pipeline of data handling and training objectives aligns the structure/property features in a common embedding space, which enables the model to regard bidirectional information between the molecules' structure and properties. These contributions emerge synergistic knowledge, allowing us to tackle both multimodal and unimodal downstream tasks through a single model. Through extensive experiments, we demonstrate that our model shows remarkable capabilities in solving various meaningful chemical challenges, including conditional molecule generation, property prediction, molecule classification, and reaction prediction.

We investigate how both the adaptation of a generic foundation model via transfer learning and the integration of complementary modalities from the operating room (OR) can support surgical data science. To this end, we use V-JEPA as the single-modality foundation of a multimodal model for minimally invasive surgery support. We analyze how the model's downstream performance can benefit (a) from finetuning on unlabeled surgical video data and (b) from providing additional time-resolved data streams from the OR in a multimodal setup. In an in-house dataset of liver surgery videos, we analyze the tasks of predicting hospital length of stay and postoperative complications. In videos of the public HeiCo dataset, we analyze the task of surgical phase recognition. As a baseline, we apply pretrained V-JEPA to all tasks. We then finetune it on unlabeled, held-out videos to investigate its change in performance after domain adaptation. Following the idea of modular decision support networks, we integrate additional data streams from the OR by training a separate encoder to form a shared representation space with V-JEPA's embeddings. Our experiments show that finetuning on domain-specific data increases model performance. On the in-house data, integrating additional time-resolved data likewise benefits the model. On the HeiCo data, accuracy of the pretrained video-only, single-modality baseline setup is on par with the top-performing submissions of the EndoVis2017 challenge, while finetuning on domain-specific data increases accuracy further. Our results thus demonstrate how surgical data science can leverage public, generic foundation models. Likewise, they indicate the potential of domain adaptation and of integrating suitable complementary data streams from the OR. To support further research, we release our code and model weights at https://github.com/DigitalSurgeryLab-Basel/ML-CDS-2025.

In this work, we discuss evaluating video foundation models in a fair and robust manner. Unlike language or image foundation models, many video foundation models are evaluated with differing parameters (such as sampling rate, number of frames, pretraining steps, etc.), making fair and robust comparisons challenging. Therefore, we present a carefully designed evaluation framework for measuring two core capabilities of video comprehension: appearance and motion understanding. Our findings reveal that existing video foundation models, whether text-supervised like UMT or InternVideo2, or self-supervised like V-JEPA, exhibit limitations in at least one of these capabilities. As an alternative, we introduce TWLV-I, a new video foundation model that constructs robust visual representations for both motion- and appearance-based videos. Based on the average top-1 accuracy of linear probing on five action recognition benchmarks, pretrained only on publicly accessible datasets, our model shows a 4.6%p improvement compared to V-JEPA (ViT-L) and a 7.7%p improvement compared to UMT (ViT-L). Even when compared to much larger models, our model demonstrates a 7.2%p improvement compared to DFN (ViT-H), a 2.7%p improvement compared to V-JEPA~(ViT-H) and a 2.8%p improvement compared to InternVideo2 (ViT-g). We provide embedding vectors obtained by TWLV-I from videos of several commonly used video benchmarks, along with evaluation source code that can directly utilize these embeddings. The code is available on "https://github.com/twelvelabs-io/video-embeddings-evaluation-framework".

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly heterogeneous tiles extracted from whole-slide images (WSIs) of real-world patient samples. The performance of these FMs is significantly influenced by the size, diversity, and balance of the pre-training data. However, data selection has been primarily guided by expert knowledge at the WSI level, focusing on factors such as disease classification and tissue types, while largely overlooking the granular details available at the tile level. In this paper, we investigate the potential of unsupervised automatic data curation at the tile-level, taking into account 350 million tiles. Specifically, we apply hierarchical clustering trees to pre-extracted tile embeddings, allowing us to sample balanced datasets uniformly across the embedding space of the pretrained FM. We further identify these datasets are subject to a trade-off between size and balance, potentially compromising the quality of representations learned by FMs, and propose tailored batch sampling strategies to mitigate this effect. We demonstrate the effectiveness of our method through improved performance on a diverse range of clinically relevant downstream tasks.

The advancement of remote sensing technology has improved the spatial resolution of satellite imagery, facilitating more detailed visual representations for diverse interpretations. However, existing methods exhibit limited generalization capabilities across varied applications. While some contemporary foundation models demonstrate potential, they are hindered by insufficient cross-task adaptability and primarily process low-resolution imagery of restricted sizes, thus failing to fully exploit high-resolution data or leverage comprehensive large-scene semantics. Crucially, remote sensing imagery differs fundamentally from natural images, as key foreground targets (eg., maritime objects, artificial structures) often occupy minimal spatial proportions (~1%) and exhibit sparse distributions. Efficiently modeling cross-task generalizable knowledge from lengthy 2D tokens (~100,000) poses a significant challenge yet remains critical for remote sensing image understanding. Motivated by the selective attention mechanisms inherent to the human visual system, we propose DynamicVis, a dynamic visual perception foundation model for remote sensing imagery. The framework integrates a novel dynamic region perception backbone based on the selective state space model, which strategically balances localized detail extraction with global contextual integration, enabling computationally efficient encoding of large-scale data while maintaining architectural scalability. To enhance cross-task knowledge transferring, we introduce a multi-instance learning paradigm utilizing meta-embedding representations, trained on million-scale region-level annotations. Evaluations across nine downstream tasks demonstrate the model's versatility. DynamicVis achieves multi-level feature modeling with exceptional efficiency, processing (2048x2048) pixels with 97 ms latency (6% of ViT's) and 833 MB GPU memory (3% of ViT's).

The field of computational pathology has recently seen rapid advances driven by the development of modern vision foundation models (FMs), typically trained on vast collections of pathology images. Recent studies demonstrate that increasing the training data set and model size and integrating domain-specific image processing techniques can significantly enhance the model's performance on downstream tasks. Building on these insights, our work incorporates several recent modifications to the standard DINOv2 framework from the literature to optimize the training of pathology FMs. We also apply a post-training procedure for fine-tuning models on higher-resolution images to further enrich the information encoded in the embeddings. We present three novel pathology FMs trained on up to two orders of magnitude fewer WSIs than those used to train other state-of-the-art FMs while demonstrating a comparable or superior performance on downstream tasks. Even the model trained on TCGA alone (12k WSIs) outperforms most existing FMs and, on average, matches Virchow2, the second-best FM published to date. This suggests that there still remains a significant potential for further improving the models and algorithms used to train pathology FMs to take full advantage of the vast data collections.

The integration of deep learning systems into the medical domain has been hindered by the resource-intensive process of data annotation and the inability of these systems to generalize to different data distributions. Foundation models, which are models pre-trained on large datasets, have emerged as a solution to reduce reliance on annotated data and enhance model generalizability and robustness. DINOv2, an open-source foundation model pre-trained with self-supervised learning on 142 million curated natural images, excels in extracting general-purpose visual representations, exhibiting promising capabilities across various vision tasks. Nevertheless, a critical question remains unanswered regarding DINOv2's adaptability to radiological imaging, and the clarity on whether its features are sufficiently general to benefit radiology image analysis is yet to be established. Therefore, this study comprehensively evaluates DINOv2 for radiology, conducting over 100 experiments across diverse modalities (X-ray, CT, and MRI). Tasks include disease classification and organ segmentation on both 2D and 3D images, evaluated under different settings like kNN, few-shot learning, linear-probing, end-to-end fine-tuning, and parameter-efficient fine-tuning, to measure the effectiveness and generalizability of the DINOv2 feature embeddings. Comparative analyses with established medical image analysis models, U-Net and TransUnet for segmentation, and CNN and ViT models pre-trained via supervised, weakly supervised, and self-supervised learning for classification, reveal DINOv2's superior performance in segmentation tasks and competitive results in disease classification. The findings contribute insights to potential avenues for optimizing pre-training strategies for medical imaging and enhancing the broader understanding of DINOv2's role in bridging the gap between natural and radiological image analysis.

The polygon mesh representation of 3D data exhibits great flexibility, fast rendering speed, and storage efficiency, which is widely preferred in various applications. However, given its unstructured graph representation, the direct generation of high-fidelity 3D meshes is challenging. Fortunately, with a pre-defined ordering strategy, 3D meshes can be represented as sequences, and the generation process can be seamlessly treated as an auto-regressive problem. In this paper, we validate the Neural Coordinate Field (NeurCF), an explicit coordinate representation with implicit neural embeddings, is a simple-yet-effective representation for large-scale sequential mesh modeling. After that, we present MeshXL, a family of generative pre-trained auto-regressive models, which addresses the process of 3D mesh generation with modern large language model approaches. Extensive experiments show that MeshXL is able to generate high-quality 3D meshes, and can also serve as foundation models for various down-stream applications.

The scaling laws and extraordinary performance of large foundation models motivate the development and utilization of such models in biomedicine. However, despite early promising results on some biomedical benchmarks, there are still major challenges that need to be addressed before these models can be used in real-world clinics. Frontier general-domain models such as GPT-4V still have significant performance gaps in multimodal biomedical applications. More importantly, less-acknowledged pragmatic issues, including accessibility, model cost, and tedious manual evaluation make it hard for clinicians to use state-of-the-art large models directly on private patient data. Here, we explore training open-source small multimodal models (SMMs) to bridge competency gaps for unmet clinical needs in radiology. To maximize data efficiency, we adopt a modular approach by incorporating state-of-the-art pre-trained models for image and text modalities, and focusing on training a lightweight adapter to ground each modality to the text embedding space, as exemplified by LLaVA-Med. For training, we assemble a large dataset of over 697 thousand radiology image-text pairs. For evaluation, we propose CheXprompt, a GPT-4-based metric for factuality evaluation, and demonstrate its parity with expert evaluation. For best practice, we conduct a systematic ablation study on various choices in data engineering and multimodal training. The resulting LlaVA-Rad (7B) model attains state-of-the-art results on standard radiology tasks such as report generation and cross-modal retrieval, even outperforming much larger models such as GPT-4V and Med-PaLM M (84B). The inference of LlaVA-Rad is fast and can be performed on a single V100 GPU in private settings, offering a promising state-of-the-art tool for real-world clinical applications.

Deep learning has enabled the development of highly robust foundation models for various pathological tasks across diverse diseases and patient cohorts. Among these models, vision-language pre-training, which leverages large-scale paired data to align pathology image and text embedding spaces, and provides a novel zero-shot paradigm for downstream tasks. However, existing models have been primarily data-driven and lack the incorporation of domain-specific knowledge, which limits their performance in cancer diagnosis, especially for rare tumor subtypes. To address this limitation, we establish a Knowledge-enhanced Pathology (KEEP) foundation model that harnesses disease knowledge to facilitate vision-language pre-training. Specifically, we first construct a disease knowledge graph (KG) that covers 11,454 human diseases with 139,143 disease attributes, including synonyms, definitions, and hypernym relations. We then systematically reorganize the millions of publicly available noisy pathology image-text pairs, into 143K well-structured semantic groups linked through the hierarchical relations of the disease KG. To derive more nuanced image and text representations, we propose a novel knowledge-enhanced vision-language pre-training approach that integrates disease knowledge into the alignment within hierarchical semantic groups instead of unstructured image-text pairs. Validated on 18 diverse benchmarks with more than 14,000 whole slide images (WSIs), KEEP achieves state-of-the-art performance in zero-shot cancer diagnostic tasks. Notably, for cancer detection, KEEP demonstrates an average sensitivity of 89.8% at a specificity of 95.0% across 7 cancer types. For cancer subtyping, KEEP achieves a median balanced accuracy of 0.456 in subtyping 30 rare brain cancers, indicating strong generalizability for diagnosing rare tumors.

Building artificial intelligence (AI) systems on top of a set of foundation models (FMs) is becoming a new paradigm in AI research. Their representative and generative abilities learnt from vast amounts of data can be easily adapted and transferred to a wide range of downstream tasks without extra training from scratch. However, leveraging FMs in cross-modal generation remains under-researched when audio modality is involved. On the other hand, automatically generating semantically-relevant sound from visual input is an important problem in cross-modal generation studies. To solve this vision-to-audio (V2A) generation problem, existing methods tend to design and build complex systems from scratch using modestly sized datasets. In this paper, we propose a lightweight solution to this problem by leveraging foundation models, specifically CLIP, CLAP, and AudioLDM. We first investigate the domain gap between the latent space of the visual CLIP and the auditory CLAP models. Then we propose a simple yet effective mapper mechanism (V2A-Mapper) to bridge the domain gap by translating the visual input between CLIP and CLAP spaces. Conditioned on the translated CLAP embedding, pretrained audio generative FM AudioLDM is adopted to produce high-fidelity and visually-aligned sound. Compared to previous approaches, our method only requires a quick training of the V2A-Mapper. We further analyze and conduct extensive experiments on the choice of the V2A-Mapper and show that a generative mapper is better at fidelity and variability (FD) while a regression mapper is slightly better at relevance (CS). Both objective and subjective evaluation on two V2A datasets demonstrate the superiority of our proposed method compared to current state-of-the-art approaches - trained with 86% fewer parameters but achieving 53% and 19% improvement in FD and CS, respectively.