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Nov 4

InterMask: 3D Human Interaction Generation via Collaborative Masked Modeling

Generating realistic 3D human-human interactions from textual descriptions remains a challenging task. Existing approaches, typically based on diffusion models, often produce results lacking realism and fidelity. In this work, we introduce InterMask, a novel framework for generating human interactions using collaborative masked modeling in discrete space. InterMask first employs a VQ-VAE to transform each motion sequence into a 2D discrete motion token map. Unlike traditional 1D VQ token maps, it better preserves fine-grained spatio-temporal details and promotes spatial awareness within each token. Building on this representation, InterMask utilizes a generative masked modeling framework to collaboratively model the tokens of two interacting individuals. This is achieved by employing a transformer architecture specifically designed to capture complex spatio-temporal inter-dependencies. During training, it randomly masks the motion tokens of both individuals and learns to predict them. For inference, starting from fully masked sequences, it progressively fills in the tokens for both individuals. With its enhanced motion representation, dedicated architecture, and effective learning strategy, InterMask achieves state-of-the-art results, producing high-fidelity and diverse human interactions. It outperforms previous methods, achieving an FID of 5.154 (vs 5.535 of in2IN) on the InterHuman dataset and 0.399 (vs 5.207 of InterGen) on the InterX dataset. Additionally, InterMask seamlessly supports reaction generation without the need for model redesign or fine-tuning.

  • 4 authors
·
Mar 1, 2025

BYOD: Build Your Own DLM - Efficient Autoregressive-to-Diffusion Language Model Conversion

Unlike autoregressive (AR) models, diffusion language models (DLMs) permit parallel token updates, flexible generation, and bidirectional attention, but leading systems rely on costly pretraining or full-model fine-tuning. We present Build Your Own DLM (BYOD), a generalizable LoRA-only recipe for parameter-efficient AR-to-DLM conversion. Without architecture-specific tuning, BYOD induces diffusion generation in Gemma 2 9B, Llama 3.1 8B, Qwen2.5 7B, and Ministral 8B; to our knowledge, this is the first reported AR-to-DLM conversion of a Mistral model. The adapters comprise 4.1-5.8% of final parameters while every base-model parameter remains frozen; each 25,000-iteration conversion needs at most 102.4M tokens, processed in 3.1-4.0 hours on one Google Colab GPU. All four models generate from fully masked sequences, use bidirectional context in a controlled attention test, and retain substantial parent-model knowledge. BYOD-Gemma is the strongest BYOD conversion on our nine-task evaluation, reaching 50.6% average accuracy compared with 51.9% for LLaDA 8B Instruct in the same harness. Open-generation quality at low network function evaluation (NFE) budgets remains the principal limitation: BYOD perplexity is 8.3-11.1 versus 4.1 for LLaDA and 2.2-3.0 for the AR parents when generating 128 tokens in 64 steps. To enable further experimentation and inspection, we provide a standalone training and evaluation implementation and interactive demos for all four conversions. BYOD thus provides a practical route for extending diffusion generation to other existing model families while identifying the gap that efficient conversion must next close.

Peptide Sequencing Via Protein Language Models

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based platforms able to sequence non-native peptides. Current protein sequencing techniques face limitations in accurately identifying all amino acids, hindering comprehensive proteome analysis. Our method simulates partial sequencing data by selectively masking amino acids that are experimentally difficult to identify in protein sequences from the UniRef database. This targeted masking mimics real-world sequencing limitations. We then modify and finetune a ProtBert derived transformer-based model, for a new downstream task predicting these masked residues, providing an approximation of the complete sequence. Evaluating on three bacterial Escherichia species, we achieve per-amino-acid accuracy up to 90.5% when only four amino acids ([KCYM]) are known. Structural assessment using AlphaFold and TM-score validates the biological relevance of our predictions. The model also demonstrates potential for evolutionary analysis through cross-species performance. This integration of simulated experimental constraints with computational predictions offers a promising avenue for enhancing protein sequence analysis, potentially accelerating advancements in proteomics and structural biology by providing a probabilistic reconstruction of the complete protein sequence from limited experimental data.

  • 12 authors
·
Aug 1, 2024

LESS Is More: Mutual-Stability Sampling for Diffusion Language Models

Diffusion large language models (dLLMs) offer a promising alternative to autoregressive decoding by iteratively refining masked sequences, enabling parallel token updates and bidirectional conditioning. Their practical efficiency, however, is limited by sampling procedures that execute a fixed number of reverse denoising steps selected before decoding, spending computation on already-stable positions and sometimes committing unstable ones too early. We present LESS, a training-free, model-agnostic adaptive sampler that treats token commitment as an online stopping problem. LESS implements mutual-stability sampling through a joint stability rule that makes a masked position eligible for unmasking only when its top-1 prediction has high confidence, its top-1 token persists across recent reverse steps, and its predictive distribution is stable under top-K inter-step Jensen--Shannon divergence. We evaluate LESS on Dream-7B, LLaDA-8B, and LLaDA-1.5-8B, covering full-sequence diffusion and semi-autoregressive blockwise sampling regimes, across seven benchmarks spanning general knowledge, math, and code. LESS improves average accuracy over strong training-free adaptive samplers while using 72.1% fewer reverse steps than fixed-budget decoding. Since each reverse step requires a Transformer forward pass, these step-count reductions translate into fewer forward evaluations, lower measured wall-clock latency, and lower estimated inference compute.

  • 3 authors
·
Jun 14

Data-Efficient Autoregressive-to-Diffusion Language Models via On-Policy Distillation

We study the transformation of autoregressive models (ARLMs) into diffusion language models (DLMs). Rather than pretraining from scratch, prior work replaces the causal attention in ARLMs with bidirectional attention and then trains the resulting model using a DLM objective. However, these approaches incur two distribution shifts. First, transitioning from a next-token prediction objective to a DLM objective can discard knowledge acquired by the ARLM during training. Second, standard DLMs suffer from a train-inference mismatch, as the training loss is defined on randomly masked sequences rather than the trajectories encountered at inference produced by confidence-based decoding. To address both challenges, we introduce an On-Policy Diffusion Language Model (OPDLM) in which On-Policy Distillation (OPD) is employed for ARLM-to-DLM transformation. Specifically, OPDLM is trained via self-OPD, where the student, an ARLM with bidirectional attention, generates its own trajectories, and the teacher, the original frozen ARLM, distills its knowledge by providing target logits on these trajectories. By training directly in an on-policy manner, OPDLM eliminates the train-inference mismatch in DLMs, while distillation from the original model enhances knowledge retention from the ARLM. Empirical results demonstrate that OPDLM requires 15x to 7,000x fewer training tokens with strong performance across a wide variety of tasks. OPDLM avoids the prohibitive cost of DLM pretraining and positions DLM transformation as a form of ARLM post-training.

GDSD: Reinforcement Learning as Guided Denoiser Self-Distillation for Diffusion Language Models

Reinforcement learning (RL) can be used to improve the policy (denoiser) of diffusion large language models (dLLMs), while being hindered by the intractability of the policy likelihood. A dominant and efficient family of methods replaces the likelihood in standard RL with its evidence lower bound (ELBO), estimated from randomly masked sequences. Despite being well aligned with pre-training, these approaches introduce bias through training--inference mismatch by using the ELBO as a likelihood surrogate, which can degrade performance. In this work, we propose Guided Denoiser Self-Distillation (GDSD) to directly distill the denoiser of dLLMs from an advantage-guided self-teacher, derived from the closed-form optimum of reverse-KL regularized RL. GDSD matches the dLLM's denoiser logits to the teacher's via a normalization-free objective, which reduces RL to likelihood-free self-distillation and thus bypasses the TIM biases. Recent ELBO-based methods emerge as instances of applying different distillation divergences, but with diagnosable pathologies that GDSD avoids. On planning, math, and coding benchmarks with LLaDA-8B and Dream-7B, GDSD consistently outperforms prior state-of-the-art ELBO-based methods with a more stable training reward dynamics, achieving test-accuracy improvements of up to +19.6%. These results suggest that direct denoiser self-distillation, without relying on an ELBO likelihood surrogate, can provide a more stable and effective RL procedure for dLLMs. Code is available at https://github.com/GaryBall/GDSD.

  • 7 authors
·
May 27 1

Pairing interacting protein sequences using masked language modeling

Predicting which proteins interact together from amino-acid sequences is an important task. We develop a method to pair interacting protein sequences which leverages the power of protein language models trained on multiple sequence alignments, such as MSA Transformer and the EvoFormer module of AlphaFold. We formulate the problem of pairing interacting partners among the paralogs of two protein families in a differentiable way. We introduce a method called DiffPALM that solves it by exploiting the ability of MSA Transformer to fill in masked amino acids in multiple sequence alignments using the surrounding context. MSA Transformer encodes coevolution between functionally or structurally coupled amino acids. We show that it captures inter-chain coevolution, while it was trained on single-chain data, which means that it can be used out-of-distribution. Relying on MSA Transformer without fine-tuning, DiffPALM outperforms existing coevolution-based pairing methods on difficult benchmarks of shallow multiple sequence alignments extracted from ubiquitous prokaryotic protein datasets. It also outperforms an alternative method based on a state-of-the-art protein language model trained on single sequences. Paired alignments of interacting protein sequences are a crucial ingredient of supervised deep learning methods to predict the three-dimensional structure of protein complexes. DiffPALM substantially improves the structure prediction of some eukaryotic protein complexes by AlphaFold-Multimer, without significantly deteriorating any of those we tested. It also achieves competitive performance with using orthology-based pairing.

  • 3 authors
·
Aug 14, 2023

Diffusion Sequence Models for Enhanced Protein Representation and Generation

Proteins are fundamental to biology, executing diverse functions through complex physicochemical interactions, and they hold transformative potential across medicine, materials science, and environmental applications. Protein Language Models (pLMs) aim to unlock insights from the vast space of unlabeled protein sequences by learning rich, semantic representations from primary sequences via masked language modeling. However, these models typically exhibit limited generative capacity. In this work, we introduce the Diffusion Sequence Model (DSM), a novel pLM trained with masked diffusion to enable both high-quality representation learning and generative protein design. DSM builds upon the ESM2 architecture by incorporating a masked forward diffusion process inspired by the LLaDA framework. After training, DSM is capable of generating diverse, biomimetic sequences that align with expected amino acid compositions, secondary structures, and predicted functions, even with 90\% token corruption. Furthermore, DSM's learned representations match or exceed those of similarly sized pLMs on downstream tasks. We also introduce DSM(ppi), a variant fine-tuned to generate protein binders by attending to target sequences. We demonstrate DSM(ppi)'s effectiveness on the challenging Bench-tested Binder Benchmark (BenchBB), where both DSM and DSM(ppi) produce candidates with superior predicted binding affinity compared to known binders. Our results establish masked diffusion as a powerful paradigm for unifying protein representation and generation in a single framework.

  • 4 authors
·
Jun 9, 2025

MambaMIM: Pre-training Mamba with State Space Token Interpolation and its Application to Medical Image Segmentation

Recently, the state space model Mamba has demonstrated efficient long-sequence modeling capabilities, particularly for addressing long-sequence visual tasks in 3D medical imaging. However, existing generative self-supervised learning methods have not yet fully unleashed Mamba's potential for handling long-range dependencies because they overlook the inherent causal properties of state space sequences in masked modeling. To address this challenge, we propose a general-purpose pre-training framework called MambaMIM, a masked image modeling method based on a novel TOKen-Interpolation strategy (TOKI) for the selective structure state space sequence, which learns causal relationships of state space within the masked sequence. Further, MambaMIM introduces a bottom-up 3D hybrid masking strategy to maintain a masking consistency across different architectures and can be used on any single or hybrid Mamba architecture to enhance its multi-scale and long-range representation capability. We pre-train MambaMIM on a large-scale dataset of 6.8K CT scans and evaluate its performance across eight public medical segmentation benchmarks. Extensive downstream experiments reveal the feasibility and advancement of using Mamba for medical image pre-training. In particular, when we apply the MambaMIM to a customized architecture that hybridizes MedNeXt and Vision Mamba, we consistently obtain the state-of-the-art segmentation performance. The code is available at: https://github.com/FengheTan9/MambaMIM.

  • 7 authors
·
Aug 15, 2024

Masked Temporal Interpolation Diffusion for Procedure Planning in Instructional Videos

In this paper, we address the challenge of procedure planning in instructional videos, aiming to generate coherent and task-aligned action sequences from start and end visual observations. Previous work has mainly relied on text-level supervision to bridge the gap between observed states and unobserved actions, but it struggles with capturing intricate temporal relationships among actions. Building on these efforts, we propose the Masked Temporal Interpolation Diffusion (MTID) model that introduces a latent space temporal interpolation module within the diffusion model. This module leverages a learnable interpolation matrix to generate intermediate latent features, thereby augmenting visual supervision with richer mid-state details. By integrating this enriched supervision into the model, we enable end-to-end training tailored to task-specific requirements, significantly enhancing the model's capacity to predict temporally coherent action sequences. Additionally, we introduce an action-aware mask projection mechanism to restrict the action generation space, combined with a task-adaptive masked proximity loss to prioritize more accurate reasoning results close to the given start and end states over those in intermediate steps. Simultaneously, it filters out task-irrelevant action predictions, leading to contextually aware action sequences. Experimental results across three widely used benchmark datasets demonstrate that our MTID achieves promising action planning performance on most metrics. The code is available at https://github.com/WiserZhou/MTID.

  • 8 authors
·
Jul 4, 2025

ReMoMask: Retrieval-Augmented Masked Motion Generation

Text-to-Motion (T2M) generation aims to synthesize realistic and semantically aligned human motion sequences from natural language descriptions. However, current approaches face dual challenges: Generative models (e.g., diffusion models) suffer from limited diversity, error accumulation, and physical implausibility, while Retrieval-Augmented Generation (RAG) methods exhibit diffusion inertia, partial-mode collapse, and asynchronous artifacts. To address these limitations, we propose ReMoMask, a unified framework integrating three key innovations: 1) A Bidirectional Momentum Text-Motion Model decouples negative sample scale from batch size via momentum queues, substantially improving cross-modal retrieval precision; 2) A Semantic Spatio-temporal Attention mechanism enforces biomechanical constraints during part-level fusion to eliminate asynchronous artifacts; 3) RAG-Classier-Free Guidance incorporates minor unconditional generation to enhance generalization. Built upon MoMask's RVQ-VAE, ReMoMask efficiently generates temporally coherent motions in minimal steps. Extensive experiments on standard benchmarks demonstrate the state-of-the-art performance of ReMoMask, achieving a 3.88% and 10.97% improvement in FID scores on HumanML3D and KIT-ML, respectively, compared to the previous SOTA method RAG-T2M. Code: https://github.com/AIGeeksGroup/ReMoMask. Website: https://aigeeksgroup.github.io/ReMoMask.

  • 4 authors
·
Aug 4, 2025 2

Heart Failure Prediction using Modal Decomposition and Masked Autoencoders for Scarce Echocardiography Databases

Heart diseases remain the leading cause of mortality worldwide, implying approximately 18 million deaths according to the WHO. In particular, heart failures (HF) press the healthcare industry to develop systems for their early, rapid, and effective prediction. This work presents an automatic system based on a novel framework which combines Modal Decomposition and Masked Autoencoders (MAE) to extend the application from heart disease classification to the more challenging and specific task of heart failure time prediction, not previously addressed to the best of authors' knowledge. This system comprises two stages. The first one transforms the data from a database of echocardiography video sequences into a large collection of annotated images compatible with the training phase of machine learning-based frameworks and deep learning-based ones. This stage includes the use of the Higher Order Dynamic Mode Decomposition (HODMD) algorithm for both data augmentation and feature extraction. The second stage builds and trains a Vision Transformer (ViT). MAEs based on a combined scheme of self-supervised (SSL) and supervised learning, so far barely explored in the literature about heart failure prediction, are adopted to effectively train the ViT from scratch, even with scarce databases. The designed neural network analyses in real-time images from echocardiography sequences to estimate the time of happening a heart failure. This approach demonstrates to improve prediction accuracy from scarce databases and to be superior to several established ViT and Convolutional Neural Network (CNN) architectures. The source code will be incorporated into the next version release of the ModelFLOWs-app software (https://github.com/modelflows/ModelFLOWs-app).

  • 5 authors
·
Apr 10, 2025

MotionMaestro: Masked Tokenization for Unified Motion Generation

Human motion generation plays an important role in applications such as character animation, virtual environments, and embodied interaction. While existing approaches have achieved remarkable progress, many of them are developed for individual tasks, including text-to-motion, pose-conditioned generation, and trajectory control. Although these tasks involve different types of conditions, a unified framework capable of handling them within a common representation would greatly simplify motion generation systems. We observe that diverse motion conditions can be naturally formulated as different observation patterns over motion sequences, where each task corresponds to a specific masking strategy. Based on this insight, we introduce MotionMaestro, a unified motion generation framework that learns a shared representation for complete motions and heterogeneous partial observations through masked motion tokenization. MotionMaestro employs a three-stage training strategy that first learns a masked motion tokenizer, then refines its reconstruction ability on clean motions, and finally trains a conditional flow-matching generator in the learned latent space. Furthermore, we introduce an observation map and an observation loss to explicitly preserve provided motion conditions during generation. With this unified representation and conditioning mechanism, MotionMaestro supports text-guided and unconditional synthesis, pose conditioning and partial completion, temporal interpolation, trajectory control, and motion continuation. Experiments on the large-scale RoMo and MotionMillion datasets show state-of-the-art performance across diverse motion generation tasks.

  • 3 authors
·
Sep 25

Masked Diffusion with Task-awareness for Procedure Planning in Instructional Videos

A key challenge with procedure planning in instructional videos lies in how to handle a large decision space consisting of a multitude of action types that belong to various tasks. To understand real-world video content, an AI agent must proficiently discern these action types (e.g., pour milk, pour water, open lid, close lid, etc.) based on brief visual observation. Moreover, it must adeptly capture the intricate semantic relation of the action types and task goals, along with the variable action sequences. Recently, notable progress has been made via the integration of diffusion models and visual representation learning to address the challenge. However, existing models employ rudimentary mechanisms to utilize task information to manage the decision space. To overcome this limitation, we introduce a simple yet effective enhancement - a masked diffusion model. The introduced mask acts akin to a task-oriented attention filter, enabling the diffusion/denoising process to concentrate on a subset of action types. Furthermore, to bolster the accuracy of task classification, we harness more potent visual representation learning techniques. In particular, we learn a joint visual-text embedding, where a text embedding is generated by prompting a pre-trained vision-language model to focus on human actions. We evaluate the method on three public datasets and achieve state-of-the-art performance on multiple metrics. Code is available at https://github.com/ffzzy840304/Masked-PDPP.

  • 5 authors
·
Sep 13, 2023

MV-JAR: Masked Voxel Jigsaw and Reconstruction for LiDAR-Based Self-Supervised Pre-Training

This paper introduces the Masked Voxel Jigsaw and Reconstruction (MV-JAR) method for LiDAR-based self-supervised pre-training and a carefully designed data-efficient 3D object detection benchmark on the Waymo dataset. Inspired by the scene-voxel-point hierarchy in downstream 3D object detectors, we design masking and reconstruction strategies accounting for voxel distributions in the scene and local point distributions within the voxel. We employ a Reversed-Furthest-Voxel-Sampling strategy to address the uneven distribution of LiDAR points and propose MV-JAR, which combines two techniques for modeling the aforementioned distributions, resulting in superior performance. Our experiments reveal limitations in previous data-efficient experiments, which uniformly sample fine-tuning splits with varying data proportions from each LiDAR sequence, leading to similar data diversity across splits. To address this, we propose a new benchmark that samples scene sequences for diverse fine-tuning splits, ensuring adequate model convergence and providing a more accurate evaluation of pre-training methods. Experiments on our Waymo benchmark and the KITTI dataset demonstrate that MV-JAR consistently and significantly improves 3D detection performance across various data scales, achieving up to a 6.3% increase in mAPH compared to training from scratch. Codes and the benchmark will be available at https://github.com/SmartBot-PJLab/MV-JAR .

  • 7 authors
·
Mar 23, 2023

SkeletonMAE: Graph-based Masked Autoencoder for Skeleton Sequence Pre-training

Skeleton sequence representation learning has shown great advantages for action recognition due to its promising ability to model human joints and topology. However, the current methods usually require sufficient labeled data for training computationally expensive models, which is labor-intensive and time-consuming. Moreover, these methods ignore how to utilize the fine-grained dependencies among different skeleton joints to pre-train an efficient skeleton sequence learning model that can generalize well across different datasets. In this paper, we propose an efficient skeleton sequence learning framework, named Skeleton Sequence Learning (SSL). To comprehensively capture the human pose and obtain discriminative skeleton sequence representation, we build an asymmetric graph-based encoder-decoder pre-training architecture named SkeletonMAE, which embeds skeleton joint sequence into Graph Convolutional Network (GCN) and reconstructs the masked skeleton joints and edges based on the prior human topology knowledge. Then, the pre-trained SkeletonMAE encoder is integrated with the Spatial-Temporal Representation Learning (STRL) module to build the SSL framework. Extensive experimental results show that our SSL generalizes well across different datasets and outperforms the state-of-the-art self-supervised skeleton-based action recognition methods on FineGym, Diving48, NTU 60 and NTU 120 datasets. Additionally, we obtain comparable performance to some fully supervised methods. The code is avaliable at https://github.com/HongYan1123/SkeletonMAE.

  • 6 authors
·
Jul 17, 2023

PepMLM: Target Sequence-Conditioned Generation of Peptide Binders via Masked Language Modeling

Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule docking at binding pockets for targeted protein degradation (TPD). The computational design of protein-based binders presents unique opportunities to access undruggable targets, but have often relied on stable 3D structures or predictions for effective binder generation. Recently, we have leveraged the expressive latent spaces of protein language models (pLMs) for the prioritization of peptide binders from sequence alone, which we have then fused to E3 ubiquitin ligase domains, creating a CRISPR-analogous TPD system for target proteins. However, our methods rely on training discriminator models for ranking heuristically or unconditionally-derived guide peptides for their target binding capability. In this work, we introduce PepMLM, a purely target sequence-conditioned de novo generator of linear peptide binders. By employing a novel masking strategy that uniquely positions cognate peptide sequences at the terminus of target protein sequences, PepMLM tasks the state-of-the-art ESM-2 pLM to fully reconstruct the binder region, achieving low perplexities matching or improving upon previously-validated peptide-protein sequence pairs. After successful in silico benchmarking with AlphaFold-Multimer, we experimentally verify PepMLM's efficacy via fusion of model-derived peptides to E3 ubiquitin ligase domains, demonstrating endogenous degradation of target substrates in cellular models. In total, PepMLM enables the generative design of candidate binders to any target protein, without the requirement of target structure, empowering downstream programmable proteome editing applications.

  • 13 authors
·
Oct 5, 2023

Text-driven Human Motion Generation with Motion Masked Diffusion Model

Text-driven human motion generation is a multimodal task that synthesizes human motion sequences conditioned on natural language. It requires the model to satisfy textual descriptions under varying conditional inputs, while generating plausible and realistic human actions with high diversity. Existing diffusion model-based approaches have outstanding performance in the diversity and multimodality of generation. However, compared to autoregressive methods that train motion encoders before inference, diffusion methods lack in fitting the distribution of human motion features which leads to an unsatisfactory FID score. One insight is that the diffusion model lack the ability to learn the motion relations among spatio-temporal semantics through contextual reasoning. To solve this issue, in this paper, we proposed Motion Masked Diffusion Model (MMDM), a novel human motion masked mechanism for diffusion model to explicitly enhance its ability to learn the spatio-temporal relationships from contextual joints among motion sequences. Besides, considering the complexity of human motion data with dynamic temporal characteristics and spatial structure, we designed two mask modeling strategies: time frames mask and body parts mask. During training, MMDM masks certain tokens in the motion embedding space. Then, the diffusion decoder is designed to learn the whole motion sequence from masked embedding in each sampling step, this allows the model to recover a complete sequence from incomplete representations. Experiments on HumanML3D and KIT-ML dataset demonstrate that our mask strategy is effective by balancing motion quality and text-motion consistency.

  • 1 authors
·
Sep 29, 2024

WAM-Diff: A Masked Diffusion VLA Framework with MoE and Online Reinforcement Learning for Autonomous Driving

End-to-end autonomous driving systems based on vision-language-action (VLA) models integrate multimodal sensor inputs and language instructions to generate planning and control signals. While autoregressive large language models and continuous diffusion policies are prevalent, the potential of discrete masked diffusion for trajectory generation remains largely unexplored. This paper presents WAM-Diff, a VLA framework that employs masked diffusion to iteratively refine a discrete sequence representing future ego-trajectories. Our approach features three key innovations: a systematic adaptation of masked diffusion for autonomous driving that supports flexible, non-causal decoding orders; scalable model capacity via a sparse MoE architecture trained jointly on motion prediction and driving-oriented visual question answering (VQA); and online reinforcement learning using Group Sequence Policy Optimization (GSPO) to optimize sequence-level driving rewards. Remarkably, our model achieves 91.0 PDMS on NAVSIM-v1 and 89.7 EPDMS on NAVSIM-v2, demonstrating the effectiveness of masked diffusion for autonomous driving. The approach provides a promising alternative to autoregressive and diffusion-based policies, supporting scenario-aware decoding strategies for trajectory generation. The code for this paper will be released publicly at: https://github.com/fudan-generative-vision/WAM-Diff

  • 11 authors
·
Dec 6, 2025

CrossVideoMAE: Self-Supervised Image-Video Representation Learning with Masked Autoencoders

Current video-based Masked Autoencoders (MAEs) primarily focus on learning effective spatiotemporal representations from a visual perspective, which may lead the model to prioritize general spatial-temporal patterns but often overlook nuanced semantic attributes like specific interactions or sequences that define actions - such as action-specific features that align more closely with human cognition for space-time correspondence. This can limit the model's ability to capture the essence of certain actions that are contextually rich and continuous. Humans are capable of mapping visual concepts, object view invariance, and semantic attributes available in static instances to comprehend natural dynamic scenes or videos. Existing MAEs for videos and static images rely on separate datasets for videos and images, which may lack the rich semantic attributes necessary for fully understanding the learned concepts, especially when compared to using video and corresponding sampled frame images together. To this end, we propose CrossVideoMAE an end-to-end self-supervised cross-modal contrastive learning MAE that effectively learns both video-level and frame-level rich spatiotemporal representations and semantic attributes. Our method integrates mutual spatiotemporal information from videos with spatial information from sampled frames within a feature-invariant space, while encouraging invariance to augmentations within the video domain. This objective is achieved through jointly embedding features of visible tokens and combining feature correspondence within and across modalities, which is critical for acquiring rich, label-free guiding signals from both video and frame image modalities in a self-supervised manner. Extensive experiments demonstrate that our approach surpasses previous state-of-the-art methods and ablation studies validate the effectiveness of our approach.

  • 6 authors
·
Feb 8, 2025

Substrate Prediction for RiPP Biosynthetic Enzymes via Masked Language Modeling and Transfer Learning

Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes often exhibit promiscuous substrate preferences that cannot be reduced to simple rules. Large language models are promising tools for predicting such peptide fitness landscapes. However, state-of-the-art protein language models are trained on relatively few peptide sequences. A previous study comprehensively profiled the peptide substrate preferences of LazBF (a two-component serine dehydratase) and LazDEF (a three-component azole synthetase) from the lactazole biosynthetic pathway. We demonstrated that masked language modeling of LazBF substrate preferences produced language model embeddings that improved downstream classification models of both LazBF and LazDEF substrates. Similarly, masked language modeling of LazDEF substrate preferences produced embeddings that improved the performance of classification models of both LazBF and LazDEF substrates. Our results suggest that the models learned functional forms that are transferable between distinct enzymatic transformations that act within the same biosynthetic pathway. Our transfer learning method improved performance and data efficiency in data-scarce scenarios. We then fine-tuned models on each data set and showed that the fine-tuned models provided interpretable insight that we anticipate will facilitate the design of substrate libraries that are compatible with desired RiPP biosynthetic pathways.

  • 4 authors
·
Feb 23, 2024

ERNIE-Gram: Pre-Training with Explicitly N-Gram Masked Language Modeling for Natural Language Understanding

Coarse-grained linguistic information, such as named entities or phrases, facilitates adequately representation learning in pre-training. Previous works mainly focus on extending the objective of BERT's Masked Language Modeling (MLM) from masking individual tokens to contiguous sequences of n tokens. We argue that such contiguously masking method neglects to model the intra-dependencies and inter-relation of coarse-grained linguistic information. As an alternative, we propose ERNIE-Gram, an explicitly n-gram masking method to enhance the integration of coarse-grained information into pre-training. In ERNIE-Gram, n-grams are masked and predicted directly using explicit n-gram identities rather than contiguous sequences of n tokens. Furthermore, ERNIE-Gram employs a generator model to sample plausible n-gram identities as optional n-gram masks and predict them in both coarse-grained and fine-grained manners to enable comprehensive n-gram prediction and relation modeling. We pre-train ERNIE-Gram on English and Chinese text corpora and fine-tune on 19 downstream tasks. Experimental results show that ERNIE-Gram outperforms previous pre-training models like XLNet and RoBERTa by a large margin, and achieves comparable results with state-of-the-art methods. The source codes and pre-trained models have been released at https://github.com/PaddlePaddle/ERNIE.

  • 7 authors
·
Oct 22, 2020

MMM: Generative Masked Motion Model

Recent advances in text-to-motion generation using diffusion and autoregressive models have shown promising results. However, these models often suffer from a trade-off between real-time performance, high fidelity, and motion editability. To address this gap, we introduce MMM, a novel yet simple motion generation paradigm based on Masked Motion Model. MMM consists of two key components: (1) a motion tokenizer that transforms 3D human motion into a sequence of discrete tokens in latent space, and (2) a conditional masked motion transformer that learns to predict randomly masked motion tokens, conditioned on the pre-computed text tokens. By attending to motion and text tokens in all directions, MMM explicitly captures inherent dependency among motion tokens and semantic mapping between motion and text tokens. During inference, this allows parallel and iterative decoding of multiple motion tokens that are highly consistent with fine-grained text descriptions, therefore simultaneously achieving high-fidelity and high-speed motion generation. In addition, MMM has innate motion editability. By simply placing mask tokens in the place that needs editing, MMM automatically fills the gaps while guaranteeing smooth transitions between editing and non-editing parts. Extensive experiments on the HumanML3D and KIT-ML datasets demonstrate that MMM surpasses current leading methods in generating high-quality motion (evidenced by superior FID scores of 0.08 and 0.429), while offering advanced editing features such as body-part modification, motion in-betweening, and the synthesis of long motion sequences. In addition, MMM is two orders of magnitude faster on a single mid-range GPU than editable motion diffusion models. Our project page is available at https://exitudio.github.io/MMM-page.

  • 4 authors
·
Dec 6, 2023

EEG2Rep: Enhancing Self-supervised EEG Representation Through Informative Masked Inputs

Self-supervised approaches for electroencephalography (EEG) representation learning face three specific challenges inherent to EEG data: (1) The low signal-to-noise ratio which challenges the quality of the representation learned, (2) The wide range of amplitudes from very small to relatively large due to factors such as the inter-subject variability, risks the models to be dominated by higher amplitude ranges, and (3) The absence of explicit segmentation in the continuous-valued sequences which can result in less informative representations. To address these challenges, we introduce EEG2Rep, a self-prediction approach for self-supervised representation learning from EEG. Two core novel components of EEG2Rep are as follows: 1) Instead of learning to predict the masked input from raw EEG, EEG2Rep learns to predict masked input in latent representation space, and 2) Instead of conventional masking methods, EEG2Rep uses a new semantic subsequence preserving (SSP) method which provides informative masked inputs to guide EEG2Rep to generate rich semantic representations. In experiments on 6 diverse EEG tasks with subject variability, EEG2Rep significantly outperforms state-of-the-art methods. We show that our semantic subsequence preserving improves the existing masking methods in self-prediction literature and find that preserving 50\% of EEG recordings will result in the most accurate results on all 6 tasks on average. Finally, we show that EEG2Rep is robust to noise addressing a significant challenge that exists in EEG data. Models and code are available at:https://github.com/Navidfoumani/EEG2Rep

  • 6 authors
·
Jun 17, 2024

Learned Relay Representations for Forward-Thinking Discrete Diffusion Models

When Masked Diffusion Models (MDMs) generate sequences through iterative refinement, the rich internal computation over masked positions is discarded, forcing every subsequent refinement step to recompute the valuable internal information stored as model representations. To avoid a hard reset between denoising rounds, we propose Learned Relay Representations (Relay), a method that allows MDMs to be forward-thinking when denoising by explicitly learning how to propagate latent information for the benefit of future denoising steps. Relay introduces a differentiable per-token channel that passes information between forward passes and is trained via truncated backpropagation through time (BPTT). We show that this framework can be scaled to state-of-the-art Diffusion Language Models (DLMs), and is seamlessly compatible with techniques like block diffusion and KV caching. We first provide a thorough justification of the design choices in Relay on a challenging Sudoku-based planning task. We then scale Relay to Fast-dLLM v2, a state-of-the-art DLM, outperforming standard supervised finetuning on coding tasks while reducing inference latency by up to 32%. Our empirical results demonstrate that state-of-the-art DLMs can be explicitly trained to relay latent information forward across decoding steps, advancing the performance-latency Pareto frontier. We provide code for all our experiments.

  • 7 authors
·
Aug 27

Frequency-Aware Self-Supervised Music Representation Learning

Self-supervised learning (SSL) has emerged as an essential paradigm for music information retrieval (MIR). While current SSL models achieve state-of-the-art performance across various MIR tasks, they typically treat audio as 1D sequences, either operating on time-domain waveforms or on flattened time-frequency-domain spectrograms. This discards the rich spatial and structural information in time-frequency representations and overlooks a fundamental intuition in music production. In particular, music is naturally represented as time-frequency grids in MIDI-based workflows, a structure that tightly corresponds to 2D spectrograms and inherently makes many MIR tasks trivial. Motivated by this intuition, we propose PupuJEPA, a visual Joint-Embedding Predictive Architecture (JEPA) that is trained directly on 2D spectrograms. Instead of applying masked language modeling (MLM) to 1D sequences, PupuJEPA learns robust representations by predicting the latent embeddings of masked 2D spectrogram patches from unmasked contexts. To optimally adapt such a visual framework to music signals, we also apply domain-specific modifications to model architecture, training scheme, and inference paradigm, with comprehensive ablation studies showing their effectiveness. Evaluations on the MARBLE benchmark show that PupuJEPA outperforms the 1D sequence-based SSL models across multiple MIR tasks in linear probing. Additionally, case studies of the attention maps also confirm that PupuJEPA captures musically meaningful patterns within the 2D time-frequency domain. Codes and checkpoints are available at: https://www.yichenggu.com/PupuJEPA/.

  • 5 authors
·
Jun 23

ViLaD: A Large Vision Language Diffusion Framework for End-to-End Autonomous Driving

End-to-end autonomous driving systems built on Vision Language Models (VLMs) have shown significant promise, yet their reliance on autoregressive architectures introduces some limitations for real-world applications. The sequential, token-by-token generation process of these models results in high inference latency and cannot perform bidirectional reasoning, making them unsuitable for dynamic, safety-critical environments. To overcome these challenges, we introduce ViLaD, a novel Large Vision Language Diffusion (LVLD) framework for end-to-end autonomous driving that represents a paradigm shift. ViLaD leverages a masked diffusion model that enables parallel generation of entire driving decision sequences, significantly reducing computational latency. Moreover, its architecture supports bidirectional reasoning, allowing the model to consider both past and future simultaneously, and supports progressive easy-first generation to iteratively improve decision quality. We conduct comprehensive experiments on the nuScenes dataset, where ViLaD outperforms state-of-the-art autoregressive VLM baselines in both planning accuracy and inference speed, while achieving a near-zero failure rate. Furthermore, we demonstrate the framework's practical viability through a real-world deployment on an autonomous vehicle for an interactive parking task, confirming its effectiveness and soundness for practical applications.

  • 9 authors
·
Aug 18, 2025

EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesis

Echocardiography is widely used for assessing cardiac function, where clinically meaningful parameters such as left-ventricular ejection fraction (EF) play a central role in diagnosis and management. Generative models capable of synthesising realistic echocardiogram videos with explicit control over such parameters are valuable for data augmentation, counterfactual analysis, and specialist training. However, existing approaches typically rely on computationally expensive multi-step sampling and aggressive temporal normalisation, limiting efficiency and applicability to heterogeneous real-world data. We introduce EchoLVFM, a one-step latent video flow-matching framework for controllable echocardiogram generation. Operating in the latent space, EchoLVFM synthesises temporally coherent videos in a single inference step, achieving a sim 50times improvement in sampling efficiency compared to multi-step flow baselines while maintaining visual fidelity. The model supports global conditioning on clinical variables, demonstrated through precise control of EF, and enables reconstruction and counterfactual generation from partially observed sequences. A masked conditioning strategy further removes fixed-length constraints, allowing shorter sequences to be retained rather than discarded. We evaluate EchoLVFM on the CAMUS dataset under challenging single-frame conditioning. Quantitative and qualitative results demonstrate competitive video quality, strong EF adherence, and 57.9% discrimination accuracy by expert clinicians which is close to chance. These findings indicate that efficient, one-step flow matching can enable practical, controllable echocardiogram video synthesis without sacrificing fidelity. Code available at: https://github.com/EngEmmanuel/EchoLVFM

mRNAutilus: Multi-Objective-Guided Discrete Generation of mRNA with Optimized Therapeutic Properties

Therapeutic mRNA design requires coordinating multiple interacting sequence features across the full transcript, where codon usage, untranslated regions (UTRs), and their coupling jointly determine stability, translation efficiency, and protein expression. Here, we present mRNA generation via unrolled trajectories and informed latent updates (mRNAutilus), a framework for simultaneous codon optimization and de novo UTR design directly from sequence. mRNAutilus combines a masked discrete diffusion model trained on millions of full-length mRNAs with Monte Carlo Tree Guidance to generate Pareto-efficient sequences under multiple functional objectives, using lightweight regressors over model embeddings to predict half-life, translation efficiency, and protein abundance. Unlike recent methods that design coding sequences and UTRs separately or rely on post hoc assembly and screening, mRNAutilus generates complete transcripts in a single process optimized across properties. Across diverse targets, zero-shot mRNAs encoding P. pyralis luciferase achieve over 400-fold higher expression than wild-type and outperform commercial and machine learning-designed baselines, including zero-shot generative approaches. Zero-shot SARS-CoV-2 Spike mRNAs exceed clinically used and commercial constructs and match or surpass lab-optimized designs with improved durability. We further demonstrate generality in therapeutic settings, including prime editing (PEMax) and programmable proteome modulation, where mRNAutilus-designed constructs enhance expression of peptide-guided E3 ligases (uAbs) for beta-catenin degradation. These results establish a sequence-based, multi-objective framework for generating functional mRNAs tailored to diverse biological applications.

  • 11 authors
·
May 29

Dream4ACT: A Shared Visual Action Interface for Multi-Embodiment Video-Action Modeling

Video generation models (VGMs) offer strong spatiotemporal priors for embodied observation--action modeling. However, joint-space action vectors lack explicit image-space structure and vary in dimensionality and semantics across embodiments, making it challenging to directly leverage the rich spatiotemporal priors of VGMs. End-effector visualizations provide an alternative but do not specify the full articulated configuration needed for robot execution. We present Dream4ACT, a world model built for joint video-action modeling across embodiments. To unify action representations across embodiments, we introduce a shared visual action interface, called action views, which render target joint configurations from four prescribed virtual cameras using URDF-based forward kinematics. This shared visual representation preserves embodiment-specific articulated geometry while allowing observation and action sequences to share a video autoencoder and diffusion transformer. Through masked flow-matching, our model supports forward dynamics, inverse dynamics, and joint observation--action generation within a single jointly trained model by varying which future sequences are corrupted. To recover executable action sequences from predicted action views, we propose a training-free, URDF-constrained multiview recovery mechanism, without a learned embodiment-specific decoder. Dream4ACT achieves an average success rate of 88.98\% on RoboTwin~2.0 and an overall score of 65.66 on TriWorldBench, supporting effective closed-loop manipulation and competitive action-conditioned multiview prediction through the visual action interface.

  • 9 authors
·
Sep 29 2

World Model on Million-Length Video And Language With RingAttention

Current language models fall short in understanding aspects of the world not easily described in words, and struggle with complex, long-form tasks. Video sequences offer valuable temporal information absent in language and static images, making them attractive for joint modeling with language. Such models could develop a understanding of both human textual knowledge and the physical world, enabling broader AI capabilities for assisting humans. However, learning from millions of tokens of video and language sequences poses challenges due to memory constraints, computational complexity, and limited datasets. To address these challenges, we curate a large dataset of diverse videos and books, utilize the RingAttention technique to scalably train on long sequences, and gradually increase context size from 4K to 1M tokens. This paper makes the following contributions: (a) Largest context size neural network: We train one of the largest context size transformers on long video and language sequences, setting new benchmarks in difficult retrieval tasks and long video understanding. (b) Solutions for overcoming vision-language training challenges, including using masked sequence packing for mixing different sequence lengths, loss weighting to balance language and vision, and model-generated QA dataset for long sequence chat. (c) A highly-optimized implementation with RingAttention, masked sequence packing, and other key features for training on millions-length multimodal sequences. (d) Fully open-sourced a family of 7B parameter models capable of processing long text documents (LWM-Text, LWM-Text-Chat) and videos (LWM, LWM-Chat) of over 1M tokens. This work paves the way for training on massive datasets of long video and language to develop understanding of both human knowledge and the multimodal world, and broader capabilities.

  • 4 authors
·
Feb 13, 2024 5

BIOSCAN-5M: A Multimodal Dataset for Insect Biodiversity

As part of an ongoing worldwide effort to comprehend and monitor insect biodiversity, this paper presents the BIOSCAN-5M Insect dataset to the machine learning community and establish several benchmark tasks. BIOSCAN-5M is a comprehensive dataset containing multi-modal information for over 5 million insect specimens, and it significantly expands existing image-based biological datasets by including taxonomic labels, raw nucleotide barcode sequences, assigned barcode index numbers, and geographical information. We propose three benchmark experiments to demonstrate the impact of the multi-modal data types on the classification and clustering accuracy. First, we pretrain a masked language model on the DNA barcode sequences of the BIOSCAN-5M dataset, and demonstrate the impact of using this large reference library on species- and genus-level classification performance. Second, we propose a zero-shot transfer learning task applied to images and DNA barcodes to cluster feature embeddings obtained from self-supervised learning, to investigate whether meaningful clusters can be derived from these representation embeddings. Third, we benchmark multi-modality by performing contrastive learning on DNA barcodes, image data, and taxonomic information. This yields a general shared embedding space enabling taxonomic classification using multiple types of information and modalities. The code repository of the BIOSCAN-5M Insect dataset is available at {https://github.com/zahrag/BIOSCAN-5M}

  • 13 authors
·
Jun 18, 2024

RoboHorizon: An LLM-Assisted Multi-View World Model for Long-Horizon Robotic Manipulation

Efficient control in long-horizon robotic manipulation is challenging due to complex representation and policy learning requirements. Model-based visual reinforcement learning (RL) has shown great potential in addressing these challenges but still faces notable limitations, particularly in handling sparse rewards and complex visual features in long-horizon environments. To address these limitations, we propose the Recognize-Sense-Plan-Act (RSPA) pipeline for long-horizon tasks and further introduce RoboHorizon, an LLM-assisted multi-view world model tailored for long-horizon robotic manipulation. In RoboHorizon, pre-trained LLMs generate dense reward structures for multi-stage sub-tasks based on task language instructions, enabling robots to better recognize long-horizon tasks. Keyframe discovery is then integrated into the multi-view masked autoencoder (MAE) architecture to enhance the robot's ability to sense critical task sequences, strengthening its multi-stage perception of long-horizon processes. Leveraging these dense rewards and multi-view representations, a robotic world model is constructed to efficiently plan long-horizon tasks, enabling the robot to reliably act through RL algorithms. Experiments on two representative benchmarks, RLBench and FurnitureBench, show that RoboHorizon outperforms state-of-the-art visual model-based RL methods, achieving a 23.35% improvement in task success rates on RLBench's 4 short-horizon tasks and a 29.23% improvement on 6 long-horizon tasks from RLBench and 3 furniture assembly tasks from FurnitureBench.

  • 4 authors
·
Jan 11, 2025

Rethinking Generative Recommender Tokenizer: Recsys-Native Encoding and Semantic Quantization Beyond LLMs

Semantic ID (SID)-based recommendation is a promising paradigm for scaling sequential recommender systems, but existing methods largely follow a semantic-centric pipeline: item embeddings are learned from foundation models and discretized using generic quantization schemes. This design is misaligned with generative recommendation objectives: semantic embeddings are weakly coupled with collaborative prediction, and generic quantization is inefficient at reducing sequential uncertainty for autoregressive modeling. To address these, we propose ReSID, a recommendation-native, principled SID framework that rethinks representation learning and quantization from the perspective of information preservation and sequential predictability, without relying on LLMs. ReSID consists of two components: (i) Field-Aware Masked Auto-Encoding (FAMAE), which learns predictive-sufficient item representations from structured features, and (ii) Globally Aligned Orthogonal Quantization (GAOQ), which produces compact and predictable SID sequences by jointly reducing semantic ambiguity and prefix-conditional uncertainty. Theoretical analysis and extensive experiments across ten datasets show the effectiveness of ReSID. ReSID consistently outperforms strong sequential and SID-based generative baselines by an average of over 10%, while reducing tokenization cost by up to 122x. Code is available at https://github.com/FuCongResearchSquad/ReSID.

Your LLM Knows the Future: Uncovering Its Multi-Token Prediction Potential

Autoregressive language models are constrained by their inherently sequential nature, generating one token at a time. This paradigm limits inference speed and parallelism, especially during later stages of generation when the direction and semantics of text are relatively certain. In this work, we propose a novel framework that leverages the inherent knowledge of vanilla autoregressive language models about future tokens, combining techniques to realize this potential and enable simultaneous prediction of multiple subsequent tokens. Our approach introduces several key innovations: (1) a masked-input formulation where multiple future tokens are jointly predicted from a common prefix; (2) a gated LoRA formulation that preserves the original LLM's functionality, while equipping it for multi-token prediction; (3) a lightweight, learnable sampler module that generates coherent sequences from the predicted future tokens; (4) a set of auxiliary training losses, including a consistency loss, to enhance the coherence and accuracy of jointly generated tokens; and (5) a speculative generation strategy that expands tokens quadratically in the future while maintaining high fidelity. Our method achieves significant speedups through supervised fine-tuning on pretrained models. For example, it generates code and math nearly 5x faster, and improves general chat and knowledge tasks by almost 2.5x. These gains come without any loss in quality.

  • 7 authors
·
Jul 15, 2025

SLIM-Brain: A Data- and Training-Efficient Foundation Model for fMRI Data Analysis

Foundation models are emerging as a powerful paradigm for fMRI analysis, but current approaches face a dual bottleneck of data- and training-efficiency. Atlas-based methods aggregate voxel signals into fixed regions of interest, reducing data dimensionality but discarding fine-grained spatial details, and requiring extremely large cohorts to train effectively as general-purpose foundation models. Atlas-free methods, on the other hand, operate directly on voxel-level information - preserving spatial fidelity but are prohibitively memory- and compute-intensive, making large-scale pre-training infeasible. We introduce SLIM-Brain (Sample-efficient, Low-memory fMRI Foundation Model for Human Brain), a new atlas-free foundation model that simultaneously improves both data- and training-efficiency. SLIM-Brain adopts a two-stage adaptive design: (i) a lightweight temporal extractor captures global context across full sequences and ranks data windows by saliency, and (ii) a 4D hierarchical encoder (Hiera-JEPA) learns fine-grained voxel-level representations only from the top-k selected windows, while deleting about 70% masked patches. Extensive experiments across seven public benchmarks show that SLIM-Brain establishes new state-of-the-art performance on diverse tasks, while requiring only 4 thousand pre-training sessions and approximately 30% of GPU memory comparing to traditional voxel-level methods.

  • 8 authors
·
Dec 26, 2025

MergeDNA: Context-aware Genome Modeling with Dynamic Tokenization through Token Merging

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently designed DNA tokenizers, existing approaches with naive masked language modeling pre-training often fail to adapt to the varying complexities of genomic sequences. Leveraging Token Merging techniques, this paper introduces a hierarchical architecture that jointly optimizes a dynamic genomic tokenizer and latent Transformers with context-aware pre-training tasks. As for network structures, the tokenization module automatically chunks adjacent bases into words by stacking multiple layers of the differentiable token merging blocks with local-window constraints, then a Latent Encoder captures the global context of these merged words by full-attention blocks. Symmetrically employing a Latent Decoder and a Local Decoder, MergeDNA learns with two pre-training tasks: Merged Token Reconstruction simultaneously trains the dynamic tokenization module and adaptively filters important tokens, while Adaptive Masked Token Modeling learns to predict these filtered tokens to capture informative contents. Extensive experiments show that MergeDNA achieves superior performance on three popular DNA benchmarks and several multi-omics tasks with fine-tuning or zero-shot evaluation, outperforming typical tokenization methods and large-scale DNA foundation models.

Westlake-University Westlake University
·
Nov 17, 2025 2

Dual Triangle Attention: Effective Bidirectional Attention Without Positional Embeddings

Bidirectional transformers are the foundation of many sequence modeling tasks across natural, biological, and chemical language domains, but they are permutation-invariant without explicit positional embeddings. In contrast, unidirectional attention inherently encodes positional information through its triangular mask, enabling models to operate without positional embeddings altogether. Here, we introduce Dual Triangle Attention, a novel bidirectional attention mechanism that separates the query-key subspace of each attention head into two complementary triangular masks: one that attends to past-and-self positions and one that attends to future-and-self positions. This design provides bidirectional context while maintaining the causal mask's implicit positional inductive bias in both directions. Using PyTorch's flex_attention, Dual Triangle Attention is implemented as a single compiled kernel call with no additional parameters beyond standard multi-head attention. We evaluated Dual Triangle Attention across three settings: (1) a synthetic argmax position probe, (2) masked language modeling (MLM) on natural language, and (3) MLM on protein sequences. In the argmax task, both Dual Triangle Attention and causal attention learn positional information without explicit positional embeddings, whereas standard bidirectional attention cannot. In the MLM experiments, Dual Triangle Attention with Rotary Positional Embeddings (RoPE) achieved the best context extension performance and strong performance across the board. These findings suggest that Dual Triangle Attention is a viable attention mechanism for bidirectional transformers, with or without positional embeddings.

  • 2 authors
·
Apr 8

Stare at What You See: Masked Image Modeling without Reconstruction

Masked Autoencoders (MAE) have been prevailing paradigms for large-scale vision representation pre-training. By reconstructing masked image patches from a small portion of visible image regions, MAE forces the model to infer semantic correlation within an image. Recently, some approaches apply semantic-rich teacher models to extract image features as the reconstruction target, leading to better performance. However, unlike the low-level features such as pixel values, we argue the features extracted by powerful teacher models already encode rich semantic correlation across regions in an intact image.This raises one question: is reconstruction necessary in Masked Image Modeling (MIM) with a teacher model? In this paper, we propose an efficient MIM paradigm named MaskAlign. MaskAlign simply learns the consistency of visible patch features extracted by the student model and intact image features extracted by the teacher model. To further advance the performance and tackle the problem of input inconsistency between the student and teacher model, we propose a Dynamic Alignment (DA) module to apply learnable alignment. Our experimental results demonstrate that masked modeling does not lose effectiveness even without reconstruction on masked regions. Combined with Dynamic Alignment, MaskAlign can achieve state-of-the-art performance with much higher efficiency. Code and models will be available at https://github.com/OpenPerceptionX/maskalign.

  • 7 authors
·
Nov 16, 2022

Fixed-Point Masked Generative Modeling

Masked Generative Models (MGMs) enable parallel decoding and achieve strong performance across modalities, but require full-sequence bidirectional transformers at every step, making training costly and degrading quality under low sampling budgets. Existing work improves efficiency via better samplers or cheaper fixed-depth denoisers, but they still allocate a fixed amount of denoiser computation to each refinement step. We introduce Fixed-Point Masked Generative Models (FP-MGMs), which replace part of the denoiser with a fixed-point solver over shared attention layers to enable adaptive depth with fewer parameters. To make it more effective for masked generation, we first introduce a cross-step consistency loss, which aligns hidden representations at neighboring denoising steps and, second, three-state reuse (3SR) which warm-starts the solver using the previous solution by treating differently unchanged, still-masked, and newly revealed tokens respectively. Together, these components define our complete training-to-inference framework for fixed-point masked generation, CoFRe. We also show that pre-trained MGMs can be converted into FP-MGMs with short fine-tuning, avoiding full retraining. Across modalities, CoFRe improves the quality and cost trade-off. On OpenWebText, CoFRe reduces parameters by 38.8\%, training time by 11.5\%, and VRAM by 16.9\%, while improving generative perplexity from 830.8 to 101.8 at a budget of 96 transformer-block forward passes, compared to MDLM. In ImageNette, CoFRe reduces training time by 48.6\% and VRAM by 50.7\%, while improving FID in all sample budgets tested. Overall, CoFRe offers a practical framework for cheaper training and stronger low-budget masked generation.

  • 5 authors
·
May 29

Insertion Language Models: Sequence Generation with Arbitrary-Position Insertions

Autoregressive models (ARMs), which predict subsequent tokens one-by-one ``from left to right,'' have achieved significant success across a wide range of sequence generation tasks. However, they struggle to accurately represent sequences that require satisfying sophisticated constraints or whose sequential dependencies are better addressed by out-of-order generation. Masked Diffusion Models (MDMs) address some of these limitations, but the process of unmasking multiple tokens simultaneously in MDMs can introduce incoherences, and MDMs cannot handle arbitrary infilling constraints when the number of tokens to be filled in is not known in advance. In this work, we introduce Insertion Language Models (ILMs), which learn to insert tokens at arbitrary positions in a sequence -- that is, they select jointly both the position and the vocabulary element to be inserted. By inserting tokens one at a time, ILMs can represent strong dependencies between tokens, and their ability to generate sequences in arbitrary order allows them to accurately model sequences where token dependencies do not follow a left-to-right sequential structure. To train ILMs, we propose a tailored network parameterization and use a simple denoising objective. Our empirical evaluation demonstrates that ILMs outperform both ARMs and MDMs on common planning tasks. Furthermore, we show that ILMs outperform MDMs and perform on par with ARMs in an unconditional text generation task while offering greater flexibility than MDMs in arbitrary-length text infilling.

  • 6 authors
·
May 8, 2025

Plug-and-Play Context Feature Reuse for Efficient Masked Generation

Masked generative models (MGMs) have emerged as a powerful framework for image synthesis, combining parallel decoding with strong bidirectional context modeling. However, generating high-quality samples typically requires many iterative decoding steps, resulting in high inference costs. A straightforward way to speed up generation is by decoding more tokens in each step, thereby reducing the total number of steps. However, when many tokens are decoded simultaneously, the model can only estimate the univariate marginal distributions independently, failing to capture the dependency among them. As a result, reducing the number of steps significantly compromises generation fidelity. In this work, we introduce ReCAP (Reused Context-Aware Prediction), a plug-and-play module that accelerates inference in MGMs by constructing low-cost steps via reusing feature embeddings from previously decoded context tokens. ReCAP interleaves standard full evaluations with lightweight steps that cache and reuse context features, substantially reducing computation while preserving the benefits of fine-grained, iterative generation. We demonstrate its effectiveness on top of three representative MGMs (MaskGIT, MAGE, and MAR), including both discrete and continuous token spaces and covering diverse architectural designs. In particular, on ImageNet256 class-conditional generation, ReCAP achieves up to 2.4x faster inference than the base model with minimal performance drop, and consistently delivers better efficiency-fidelity trade-offs under various generation settings.

  • 4 authors
·
May 25, 2025

TimeMAE: Self-Supervised Representations of Time Series with Decoupled Masked Autoencoders

Learning transferable representations from unlabeled time series is crucial for improving performance in data-scarce classification. Existing self-supervised methods often operate at the point level and rely on unidirectional encoding, leading to low semantic density and a mismatch between pre-training and downstream optimization. In this paper, we propose TimeMAE, a self-supervised framework that reformulates masked modeling for time series via semantic unit elevation and decoupled representation learning. Instead of modeling individual time steps, TimeMAE segments time series into non-overlapping sub-series to form semantically enriched units, enabling more informative masked reconstruction while reducing computational cost. To address the representation discrepancy introduced by masking, we design a decoupled masked autoencoder that separately encodes visible and masked regions, avoiding artificial masked tokens in the main encoder. To guide pre-training, we introduce two complementary objectives: masked codeword classification, which discretizes sub-series semantics via a learned tokenizer and masked representation regression, which aligns continuous representations through a momentum-updated target encoder. Extensive experiments on five datasets demonstrate that TimeMAE outperforms competitive baselines, particularly in label-scarce scenarios and transfer learning scenarios.

  • 7 authors
·
Feb 26

ColorMAE: Exploring data-independent masking strategies in Masked AutoEncoders

Masked AutoEncoders (MAE) have emerged as a robust self-supervised framework, offering remarkable performance across a wide range of downstream tasks. To increase the difficulty of the pretext task and learn richer visual representations, existing works have focused on replacing standard random masking with more sophisticated strategies, such as adversarial-guided and teacher-guided masking. However, these strategies depend on the input data thus commonly increasing the model complexity and requiring additional calculations to generate the mask patterns. This raises the question: Can we enhance MAE performance beyond random masking without relying on input data or incurring additional computational costs? In this work, we introduce a simple yet effective data-independent method, termed ColorMAE, which generates different binary mask patterns by filtering random noise. Drawing inspiration from color noise in image processing, we explore four types of filters to yield mask patterns with different spatial and semantic priors. ColorMAE requires no additional learnable parameters or computational overhead in the network, yet it significantly enhances the learned representations. We provide a comprehensive empirical evaluation, demonstrating our strategy's superiority in downstream tasks compared to random masking. Notably, we report an improvement of 2.72 in mIoU in semantic segmentation tasks relative to baseline MAE implementations.

  • 3 authors
·
Jul 17, 2024 2

Enhanced Masked Diffusion Unlearning

Masked diffusion language models (MDLMs) generate text by iteratively unmasking tokens with bidirectional context. As these models reach real-world deployment, machine unlearning becomes essential. This process aims to remove the influence of a designated "forget set" without retraining from scratch, so that sensitive, copyrighted, or restricted content can no longer be elicited while preserving retained capabilities. Masked Diffusion Unlearning (MDU) is the first publicly available unlearning method customized for these models: it tunes the model p_θ to match a frozen prompt-masked anchor p_{anchor} on the forget set by minimizing the anchor-last divergence KL(p_θVert p_{anchor}). We identify two failure modes of MDU. First, random answer masking can leave key forget tokens visible to the anchor even when the question is fully masked. Second, at a memorized (near-one-hot) prediction, the anchor-last logit gradient vanishes while the anchor-first divergence KL(p_{anchor} Vert p_θ) logit gradient does not. As a result, MDU training stalls on the tokens we most need to forget. Backed by theoretical and empirical analyses, we propose Enhanced Masked Diffusion Unlearning (EMDU): anchor-first KL divergence toward a frozen anchor whose entire answer span is masked. On TOFU and RWKU benchmarks using LLaDA-8B and Dream-7B, our EMDU matches or exceeds the forgetting of MDU and adapted AR baselines, while better preserving retain utility.

  • 2 authors
·
Oct 17

Making the Most of your Model: Methods for Finetuning and Applying Pretrained Transformers

This thesis provides methods and analysis of models which make progress on this goal. The techniques outlined are task agnostic, and should provide benefit when used with nearly any transformer LM. We introduce two new finetuning methods which add new capabilities to the models they are used on. The first adds a recurrence mechanism, which removes the fixed-window sized constraint and improves the efficiency of a transformer decoder. The second allows masked language models (MLMs) to be used for initialization of both the encoder and decoder of a non-autoregressive sequence-to-sequence transformer, opening up generative applications of models which were previously only used for natural language understanding tasks. We also introduce two new techniques for improving the quality of predictions of any transformer decoder without additional finetuning. One, hidden state optimization, can be applied to any transformer decoder to improve the quality of predictions at inference time, especially for few-shot classification. The other, conditional beam search, allows practitioners to search for natural language generation (NLG) model outputs with high likelihood while conditioning on the event that the output is not degenerate (e.g. empty, repetitive, etc.). Finally, we provide theoretical and empirical insights on the divergence of model-likelihood and output quality which has widely been observed in prior work. These insights apply to any model which represents a distribution over text, and apply to language models which are not transformers or even autoregressive. We argue that the NLP community has, to some extent, misunderstood the implications of these findings, and encourage a point of view which has more nuance.

  • 1 authors
·
Aug 28, 2024

SongMASS: Automatic Song Writing with Pre-training and Alignment Constraint

Automatic song writing aims to compose a song (lyric and/or melody) by machine, which is an interesting topic in both academia and industry. In automatic song writing, lyric-to-melody generation and melody-to-lyric generation are two important tasks, both of which usually suffer from the following challenges: 1) the paired lyric and melody data are limited, which affects the generation quality of the two tasks, considering a lot of paired training data are needed due to the weak correlation between lyric and melody; 2) Strict alignments are required between lyric and melody, which relies on specific alignment modeling. In this paper, we propose SongMASS to address the above challenges, which leverages masked sequence to sequence (MASS) pre-training and attention based alignment modeling for lyric-to-melody and melody-to-lyric generation. Specifically, 1) we extend the original sentence-level MASS pre-training to song level to better capture long contextual information in music, and use a separate encoder and decoder for each modality (lyric or melody); 2) we leverage sentence-level attention mask and token-level attention constraint during training to enhance the alignment between lyric and melody. During inference, we use a dynamic programming strategy to obtain the alignment between each word/syllable in lyric and note in melody. We pre-train SongMASS on unpaired lyric and melody datasets, and both objective and subjective evaluations demonstrate that SongMASS generates lyric and melody with significantly better quality than the baseline method without pre-training or alignment constraint.

  • 7 authors
·
Dec 9, 2020

MetaState: Persistent Working Memory Enhances Reasoning in Discrete Diffusion Language Models

Discrete diffusion language models (dLLMs) generate text by iteratively denoising a masked sequence. However, standard dLLMs condition each denoising step solely on the current hard-masked sequence, while intermediate continuous representations are discarded after sampling and remasking. We term this bottleneck the Information Island issue: continuous information remains isolated within individual denoising steps and fails to propagate across the trajectory. This bottleneck is especially harmful for reasoning, which requires intermediate reasoning state to be preserved and updated across many denoising steps. To address this limitation, we introduce MetaState, a lightweight recurrent augmentation that equips a frozen dLLM backbone with persistent, fixed-size working memory. MetaState comprises three modules with a shared time conditioner: a cross-attention Mixer that reads backbone activations into memory slots, a GRU-style Updater that integrates information across steps, and a cross-attention Injector that writes the updated memory back into the backbone. We train these modules with a dedicated K-step unrolling pipeline to learn multi-step dynamics. MetaState adds only {sim}0.6% trainable parameters while keeping the backbone frozen, and consistently improves reasoning performance over frozen baselines on mathematical reasoning and code generation benchmarks, with an average gain of 4.5% across all evaluations.

  • 8 authors
·
Mar 29

Bridging Textual-Collaborative Gap through Semantic Codes for Sequential Recommendation

In recent years, substantial research efforts have been devoted to enhancing sequential recommender systems by integrating abundant side information with ID-based collaborative information. This study specifically focuses on leveraging the textual metadata (e.g., titles and brands) associated with items. While existing methods have achieved notable success by combining text and ID representations, they often struggle to strike a balance between textual information embedded in text representations and collaborative information from sequential patterns of user behavior. In light of this, we propose CCFRec, a novel Code-based textual and Collaborative semantic Fusion method for sequential Recommendation. The key idea behind our approach is to bridge the gap between textual and collaborative information using semantic codes. Specifically, we generate fine-grained semantic codes from multi-view text embeddings through vector quantization techniques. Subsequently, we develop a code-guided semantic-fusion module based on the cross-attention mechanism to flexibly extract and integrate relevant information from text representations. In order to further enhance the fusion of textual and collaborative semantics, we introduce an optimization strategy that employs code masking with two specific objectives: masked code modeling and masked sequence alignment. The merit of these objectives lies in leveraging mask prediction tasks and augmented item representations to capture code correlations within individual items and enhance the sequence modeling of the recommendation backbone. Extensive experiments conducted on four public datasets demonstrate the superiority of CCFRec, showing significant improvements over various sequential recommendation models. Our code is available at https://github.com/RUCAIBox/CCFRec.

  • 4 authors
·
May 25, 2025

Enabling Approximate Joint Sampling in Diffusion LMs

In autoregressive language models, each token is sampled by conditioning on all the past tokens; the overall string has thus been sampled from the correct underlying joint distribution represented by the model. In contrast, masked diffusion language models generate text by unmasking tokens out of order and potentially in parallel. Generating an overall string sampled from the correct underlying joint distribution would (again) require exactly one token unmasking in every full-model forward pass. The more tokens unmasked in parallel, the further away the string is from the true joint; this can be seen in the resulting drop in accuracy (but, increase in speed). In this paper we devise a way to {\em approximately} sample multiple tokens from the joint distribution in a single full-model forward pass; we do so by developing a new lightweight single-layer ``sampler" on top of an existing large diffusion LM. One forward pass of the full model can now be followed by multiple forward passes of only this sampler layer, to yield multiple unmasked tokens. Our sampler is trained to mimic exact joint sampling from the (frozen) full model. We show the effectiveness of our approximate joint sampling for both pretrained-only (Dream-7B-Base) and instruction-tuned (Dream-7B-Instruct) models on language modeling and math \& coding tasks. When four tokens are unmasked for each full-model denoising step, our sampling algorithm achieves a MAUVE score of 0.87 (vs marginal baseline of 0.31) with respect to the true joint distribution.

  • 2 authors
·
Sep 25, 2025

LMD: Faster Image Reconstruction with Latent Masking Diffusion

As a class of fruitful approaches, diffusion probabilistic models (DPMs) have shown excellent advantages in high-resolution image reconstruction. On the other hand, masked autoencoders (MAEs), as popular self-supervised vision learners, have demonstrated simpler and more effective image reconstruction and transfer capabilities on downstream tasks. However, they all require extremely high training costs, either due to inherent high temporal-dependence (i.e., excessively long diffusion steps) or due to artificially low spatial-dependence (i.e., human-formulated high mask ratio, such as 0.75). To the end, this paper presents LMD, a faster image reconstruction framework with latent masking diffusion. First, we propose to project and reconstruct images in latent space through a pre-trained variational autoencoder, which is theoretically more efficient than in the pixel-based space. Then, we combine the advantages of MAEs and DPMs to design a progressive masking diffusion model, which gradually increases the masking proportion by three different schedulers and reconstructs the latent features from simple to difficult, without sequentially performing denoising diffusion as in DPMs or using fixed high masking ratio as in MAEs, so as to alleviate the high training time-consumption predicament. Our approach allows for learning high-capacity models and accelerate their training (by 3x or more) and barely reduces the original accuracy. Inference speed in downstream tasks also significantly outperforms the previous approaches.

  • 4 authors
·
Dec 13, 2023

Reconsidering Positional Supervision in Masked Diffusion Language Model Training

Masked diffusion language models (MDLMs) generate text by unmasking tokens in parallel and have recently emerged as alternatives to autoregressive language models. They can be viewed as parallel decoders trained with a position-wise cross-entropy (CE) loss, the same setup as non-autoregressive translation (NAT). In NAT, CE-trained parallel decoders have been argued to be sensitive to small positional shifts, since CE penalizes them harshly. We ask whether CE-trained MDLMs are similarly sensitive to such shifts under iterative decoding. To probe this, we apply a controlled intervention that introduces them during decoding. On LLaDA-8B-Instruct with Arena-Hard, displacing as little as 1% of generated tokens by one position substantially reduces win rates against the unintervened model, showing that MDLMs are sensitive to such small shifts under iterative parallel decoding. Motivated by this, we adapt connectionist temporal classification (CTC), an alignment-flexible objective known to mitigate it there, to MDLM supervised fine-tuning. By relaxing the strict position-wise match that CE imposes, CTC gives the loss room to absorb small positional shifts; concretely, we modified CTC objective to use a special <slack> token that absorbs positional uncertainty between target tokens and output positions, and a updated collapse map that preserves target surface forms. Across four open-ended generation benchmarks, the resulting model consistently improves over both the original model and a matched cross-entropy-trained baseline, with statistically significant gains on all four. These results identify training-side alignment flexibility as a useful design dimension for MDLM SFT, complementary to the inference-time approaches explored in prior work.

  • 4 authors
·
May 31