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May 14

CPKD: Clinical Prior Knowledge-Constrained Diffusion Models for Surgical Phase Recognition in Endoscopic Submucosal Dissection

Gastrointestinal malignancies constitute a leading cause of cancer-related mortality worldwide, with advanced-stage prognosis remaining particularly dismal. Originating as a groundbreaking technique for early gastric cancer treatment, Endoscopic Submucosal Dissection has evolved into a versatile intervention for diverse gastrointestinal lesions. While computer-assisted systems significantly enhance procedural precision and safety in ESD, their clinical adoption faces a critical bottleneck: reliable surgical phase recognition within complex endoscopic workflows. Current state-of-the-art approaches predominantly rely on multi-stage refinement architectures that iteratively optimize temporal predictions. In this paper, we present Clinical Prior Knowledge-Constrained Diffusion (CPKD), a novel generative framework that reimagines phase recognition through denoising diffusion principles while preserving the core iterative refinement philosophy. This architecture progressively reconstructs phase sequences starting from random noise and conditioned on visual-temporal features. To better capture three domain-specific characteristics, including positional priors, boundary ambiguity, and relation dependency, we design a conditional masking strategy. Furthermore, we incorporate clinical prior knowledge into the model training to improve its ability to correct phase logical errors. Comprehensive evaluations on ESD820, Cholec80, and external multi-center demonstrate that our proposed CPKD achieves superior or comparable performance to state-of-the-art approaches, validating the effectiveness of diffusion-based generative paradigms for surgical phase recognition.

  • 7 authors
·
Jul 4, 2025

Improved Robustness for Deep Learning-based Segmentation of Multi-Center Myocardial Perfusion MRI Datasets Using Data Adaptive Uncertainty-guided Space-time Analysis

Background. Fully automatic analysis of myocardial perfusion MRI datasets enables rapid and objective reporting of stress/rest studies in patients with suspected ischemic heart disease. Developing deep learning techniques that can analyze multi-center datasets despite limited training data and variations in software and hardware is an ongoing challenge. Methods. Datasets from 3 medical centers acquired at 3T (n = 150 subjects) were included: an internal dataset (inD; n = 95) and two external datasets (exDs; n = 55) used for evaluating the robustness of the trained deep neural network (DNN) models against differences in pulse sequence (exD-1) and scanner vendor (exD-2). A subset of inD (n = 85) was used for training/validation of a pool of DNNs for segmentation, all using the same spatiotemporal U-Net architecture and hyperparameters but with different parameter initializations. We employed a space-time sliding-patch analysis approach that automatically yields a pixel-wise "uncertainty map" as a byproduct of the segmentation process. In our approach, a given test case is segmented by all members of the DNN pool and the resulting uncertainty maps are leveraged to automatically select the "best" one among the pool of solutions. Results. The proposed DAUGS analysis approach performed similarly to the established approach on the internal dataset (p = n.s.) whereas it significantly outperformed on the external datasets (p < 0.005 for exD-1 and exD-2). Moreover, the number of image series with "failed" segmentation was significantly lower for the proposed vs. the established approach (4.3% vs. 17.1%, p < 0.0005). Conclusions. The proposed DAUGS analysis approach has the potential to improve the robustness of deep learning methods for segmentation of multi-center stress perfusion datasets with variations in the choice of pulse sequence, site location or scanner vendor.

  • 11 authors
·
Aug 8, 2024

Multi-Crit: Benchmarking Multimodal Judges on Pluralistic Criteria-Following

Large multimodal models (LMMs) are increasingly adopted as judges in multimodal evaluation systems due to their strong instruction following and consistency with human preferences. However, their ability to follow diverse, fine-grained evaluation criteria remains underexplored. We develop Multi-Crit, a benchmark for evaluating multimodal judges on their capacity to follow pluralistic criteria and produce reliable criterion-level judgments. Covering both open-ended generation and verifiable reasoning tasks, Multi-Crit is built through a rigorous data curation pipeline that gathers challenging response pairs with multi-criterion human annotations. It further introduces three novel metrics for systematically assessing pluralistic adherence, criterion-switching flexibility, and the ability to recognize criterion-level preference conflicts. Comprehensive analysis of 25 LMMs reveals that 1) proprietary models still struggle to maintain consistent adherence to pluralistic criteria--especially in open-ended evaluation; 2) open-source models lag further behind in flexibly following diverse criteria; and 3) critic fine-tuning with holistic judgment signals enhances visual grounding but fails to generalize to pluralistic criterion-level judgment. Additional analyses on reasoning fine-tuning, test-time scaling, and boundary consistency between open-source and proprietary models further probe the limits of current multimodal judges. As a pioneering study, Multi-Crit lays the foundation for building reliable and steerable multimodal AI evaluation.

EvalAgent: Discovering Implicit Evaluation Criteria from the Web

Evaluation of language model outputs on structured writing tasks is typically conducted with a number of desirable criteria presented to human evaluators or large language models (LLMs). For instance, on a prompt like "Help me draft an academic talk on coffee intake vs research productivity", a model response may be evaluated for criteria like accuracy and coherence. However, high-quality responses should do more than just satisfy basic task requirements. An effective response to this query should include quintessential features of an academic talk, such as a compelling opening, clear research questions, and a takeaway. To help identify these implicit criteria, we introduce EvalAgent, a novel framework designed to automatically uncover nuanced and task-specific criteria. EvalAgent first mines expert-authored online guidance. It then uses this evidence to propose diverse, long-tail evaluation criteria that are grounded in reliable external sources. Our experiments demonstrate that the grounded criteria produced by EvalAgent are often implicit (not directly stated in the user's prompt), yet specific (high degree of lexical precision). Further, EvalAgent criteria are often not satisfied by initial responses but they are actionable, such that responses can be refined to satisfy them. Finally, we show that combining LLM-generated and EvalAgent criteria uncovers more human-valued criteria than using LLMs alone.

  • 6 authors
·
Apr 21, 2025

MiroEval: Benchmarking Multimodal Deep Research Agents in Process and Outcome

Recent progress in deep research systems has been impressive, but evaluation still lags behind real user needs. Existing benchmarks predominantly assess final reports using fixed rubrics, failing to evaluate the underlying research process. Most also offer limited multimodal coverage, rely on synthetic tasks that do not reflect real-world query complexity, and cannot be refreshed as knowledge evolves. To address these gaps, we introduce MiroEval, a benchmark and evaluation framework for deep research systems. The benchmark comprises 100 tasks (70 text-only, 30 multimodal), all grounded in real user needs and constructed via a dual-path pipeline that supports periodic updates, enabling a live and evolving setting. The proposed evaluation suite assesses deep research systems along three complementary dimensions: adaptive synthesis quality evaluation with task-specific rubrics, agentic factuality verification via active retrieval and reasoning over both web sources and multimodal attachments, and process-centric evaluation audits how the system searches, reasons, and refines throughout its investigation. Evaluation across 13 systems yields three principal findings: the three evaluation dimensions capture complementary aspects of system capability, with each revealing distinct strengths and weaknesses across systems; process quality serves as a reliable predictor of overall outcome while revealing weaknesses invisible to output-level metrics; and multimodal tasks pose substantially greater challenges, with most systems declining by 3 to 10 points. The MiroThinker series achieves the most balanced performance, with MiroThinker-H1 ranking the highest overall in both settings. Human verification and robustness results confirm the reliability of the benchmark and evaluation framework. MiroEval provides a holistic diagnostic tool for the next generation of deep research agents.

miromind-ai MiroMind AI
·
Mar 30 5

MedBench v4: A Robust and Scalable Benchmark for Evaluating Chinese Medical Language Models, Multimodal Models, and Intelligent Agents

Recent advances in medical large language models (LLMs), multimodal models, and agents demand evaluation frameworks that reflect real clinical workflows and safety constraints. We present MedBench v4, a nationwide, cloud-based benchmarking infrastructure comprising over 700,000 expert-curated tasks spanning 24 primary and 91 secondary specialties, with dedicated tracks for LLMs, multimodal models, and agents. Items undergo multi-stage refinement and multi-round review by clinicians from more than 500 institutions, and open-ended responses are scored by an LLM-as-a-judge calibrated to human ratings. We evaluate 15 frontier models. Base LLMs reach a mean overall score of 54.1/100 (best: Claude Sonnet 4.5, 62.5/100), but safety and ethics remain low (18.4/100). Multimodal models perform worse overall (mean 47.5/100; best: GPT-5, 54.9/100), with solid perception yet weaker cross-modal reasoning. Agents built on the same backbones substantially improve end-to-end performance (mean 79.8/100), with Claude Sonnet 4.5-based agents achieving up to 85.3/100 overall and 88.9/100 on safety tasks. MedBench v4 thus reveals persisting gaps in multimodal reasoning and safety for base models, while showing that governance-aware agentic orchestration can markedly enhance benchmarked clinical readiness without sacrificing capability. By aligning tasks with Chinese clinical guidelines and regulatory priorities, the platform offers a practical reference for hospitals, developers, and policymakers auditing medical AI.

  • 18 authors
·
Nov 18, 2025

Who Evaluates AI's Social Impacts? Mapping Coverage and Gaps in First and Third Party Evaluations

Foundation models are increasingly central to high-stakes AI systems, and governance frameworks now depend on evaluations to assess their risks and capabilities. Although general capability evaluations are widespread, social impact assessments covering bias, fairness, privacy, environmental costs, and labor practices remain uneven across the AI ecosystem. To characterize this landscape, we conduct the first comprehensive analysis of both first-party and third-party social impact evaluation reporting across a wide range of model developers. Our study examines 186 first-party release reports and 183 post-release evaluation sources, and complements this quantitative analysis with interviews of model developers. We find a clear division of evaluation labor: first-party reporting is sparse, often superficial, and has declined over time in key areas such as environmental impact and bias, while third-party evaluators including academic researchers, nonprofits, and independent organizations provide broader and more rigorous coverage of bias, harmful content, and performance disparities. However, this complementarity has limits. Only model developers can authoritatively report on data provenance, content moderation labor, financial costs, and training infrastructure, yet interviews reveal that these disclosures are often deprioritized unless tied to product adoption or regulatory compliance. Our findings indicate that current evaluation practices leave major gaps in assessing AI's societal impacts, highlighting the urgent need for policies that promote developer transparency, strengthen independent evaluation ecosystems, and create shared infrastructure to aggregate and compare third-party evaluations in a consistent and accessible way.

  • 35 authors
·
Nov 6, 2025

MM-Vet: Evaluating Large Multimodal Models for Integrated Capabilities

We propose MM-Vet, an evaluation benchmark that examines large multimodal models (LMMs) on complicated multimodal tasks. Recent LMMs have shown various intriguing abilities, such as solving math problems written on the blackboard, reasoning about events and celebrities in news images, and explaining visual jokes. Rapid model advancements pose challenges to evaluation benchmark development. Problems include: (1) How to systematically structure and evaluate the complicated multimodal tasks; (2) How to design evaluation metrics that work well across question and answer types; and (3) How to give model insights beyond a simple performance ranking. To this end, we present MM-Vet, designed based on the insight that the intriguing ability to solve complicated tasks is often achieved by a generalist model being able to integrate different core vision-language (VL) capabilities. MM-Vet defines 6 core VL capabilities and examines the 16 integrations of interest derived from the capability combination. For evaluation metrics, we propose an LLM-based evaluator for open-ended outputs. The evaluator enables the evaluation across different question types and answer styles, resulting in a unified scoring metric. We evaluate representative LMMs on MM-Vet, providing insights into the capabilities of different LMM system paradigms and models. Code and data are available at https://github.com/yuweihao/MM-Vet.

  • 8 authors
·
Aug 4, 2023

Identifying Multiple Personalities in Large Language Models with External Evaluation

As Large Language Models (LLMs) are integrated with human daily applications rapidly, many societal and ethical concerns are raised regarding the behavior of LLMs. One of the ways to comprehend LLMs' behavior is to analyze their personalities. Many recent studies quantify LLMs' personalities using self-assessment tests that are created for humans. Yet many critiques question the applicability and reliability of these self-assessment tests when applied to LLMs. In this paper, we investigate LLM personalities using an alternate personality measurement method, which we refer to as the external evaluation method, where instead of prompting LLMs with multiple-choice questions in the Likert scale, we evaluate LLMs' personalities by analyzing their responses toward open-ended situational questions using an external machine learning model. We first fine-tuned a Llama2-7B model as the MBTI personality predictor that outperforms the state-of-the-art models as the tool to analyze LLMs' responses. Then, we prompt the LLMs with situational questions and ask them to generate Twitter posts and comments, respectively, in order to assess their personalities when playing two different roles. Using the external personality evaluation method, we identify that the obtained personality types for LLMs are significantly different when generating posts versus comments, whereas humans show a consistent personality profile in these two different situations. This shows that LLMs can exhibit different personalities based on different scenarios, thus highlighting a fundamental difference between personality in LLMs and humans. With our work, we call for a re-evaluation of personality definition and measurement in LLMs.

  • 9 authors
·
Feb 21, 2024

CompassJudger-1: All-in-one Judge Model Helps Model Evaluation and Evolution

Efficient and accurate evaluation is crucial for the continuous improvement of large language models (LLMs). Among various assessment methods, subjective evaluation has garnered significant attention due to its superior alignment with real-world usage scenarios and human preferences. However, human-based evaluations are costly and lack reproducibility, making precise automated evaluators (judgers) vital in this process. In this report, we introduce CompassJudger-1, the first open-source all-in-one judge LLM. CompassJudger-1 is a general-purpose LLM that demonstrates remarkable versatility. It is capable of: 1. Performing unitary scoring and two-model comparisons as a reward model; 2. Conducting evaluations according to specified formats; 3. Generating critiques; 4. Executing diverse tasks like a general LLM. To assess the evaluation capabilities of different judge models under a unified setting, we have also established JudgerBench, a new benchmark that encompasses various subjective evaluation tasks and covers a wide range of topics. CompassJudger-1 offers a comprehensive solution for various evaluation tasks while maintaining the flexibility to adapt to diverse requirements. Both CompassJudger and JudgerBench are released and available to the research community athttps://github.com/open-compass/CompassJudger. We believe that by open-sourcing these tools, we can foster collaboration and accelerate progress in LLM evaluation methodologies.

  • 6 authors
·
Oct 21, 2024 2

RoboArena: Distributed Real-World Evaluation of Generalist Robot Policies

Comprehensive, unbiased, and comparable evaluation of modern generalist policies is uniquely challenging: existing approaches for robot benchmarking typically rely on heavy standardization, either by specifying fixed evaluation tasks and environments, or by hosting centralized ''robot challenges'', and do not readily scale to evaluating generalist policies across a broad range of tasks and environments. In this work, we propose RoboArena, a new approach for scalable evaluation of generalist robot policies in the real world. Instead of standardizing evaluations around fixed tasks, environments, or locations, we propose to crowd-source evaluations across a distributed network of evaluators. Importantly, evaluators can freely choose the tasks and environments they evaluate on, enabling easy scaling of diversity, but they are required to perform double-blind evaluations over pairs of policies. Then, by aggregating preference feedback from pairwise comparisons across diverse tasks and environments, we can derive a ranking of policies. We instantiate our approach across a network of evaluators at seven academic institutions using the DROID robot platform. Through more than 600 pairwise real-robot evaluation episodes across seven generalist policies, we demonstrate that our crowd-sourced approach can more accurately rank the performance of existing generalist policies than conventional, centralized evaluation approaches, while being more scalable, resilient, and trustworthy. We open our evaluation network to the community and hope that it can enable more accessible comparisons of generalist robot policies.

  • 30 authors
·
Jun 22, 2025

Wider and Deeper LLM Networks are Fairer LLM Evaluators

Measuring the quality of responses generated by LLMs is a challenging task, particularly when it comes to evaluating whether the response is aligned with human preference. A novel approach involves using the LLM itself to make evaluation and stabilizing the results through multiple independent evaluations, similar to a single-layer narrow LLM network. This network consists of a fixed number of neurons, with each neuron being the same LLM. In this paper, we draw upon the extensive research on deep neural networks to explore whether deeper and wider networks can lead to fairer evaluations. Specifically, inspired by the observation that different neurons in a neural network are responsible for detecting different concepts, we first adaptively generate as many neuron roles as possible for each evaluation sample. Each perspective corresponds to the role of a specific LLM neuron in the first layer. In subsequent layers, we follow the idea that higher layers in deep networks are responsible for more comprehensive features, each layer receives representations from all neurons in the previous layer, integrating the locally learned evaluation information to obtain a more comprehensive evaluation result. Interestingly, this network design resembles the process of academic paper reviewing. To validate the effectiveness of our method, we construct the largest and most diverse English evaluation benchmark LLMEval^2 for LLM evaluators, comprising 15 tasks, 8 abilities, and 2,553 samples. Experimental results demonstrate that a wider network (involving many reviewers) with 2 layers (one round of discussion) performs the best, improving kappa correlation coefficient from 0.28 to 0.34. We also leverage WideDeep to aid in the assessment of Chinese LLMs, which has accelerated the evaluation time by 4.6 times, resulting in a 60% cost saving. WideDeep achieves a remarkable 93% agreement level among humans.

  • 8 authors
·
Aug 3, 2023

Cross-Lingual Auto Evaluation for Assessing Multilingual LLMs

Evaluating machine-generated text remains a significant challenge in NLP, especially for non-English languages. Current methodologies, including automated metrics, human assessments, and LLM-based evaluations, predominantly focus on English, revealing a significant gap in multilingual evaluation frameworks. We introduce the Cross Lingual Auto Evaluation (CIA) Suite, an extensible framework that includes evaluator LLMs (Hercule) and a novel test set (Recon) specifically designed for multilingual evaluation. Our test set features 500 human-annotated instructions spanning various task capabilities along with human judgment scores across six languages. This would enable benchmarking of general-purpose multilingual LLMs and facilitate meta-evaluation of Evaluator LLMs. The proposed model, Hercule, is a cross-lingual evaluation model that addresses the scarcity of reference answers in the target language by learning to assign scores to responses based on easily available reference answers in English. Our experiments demonstrate that Hercule aligns more closely with human judgments compared to proprietary models, demonstrating the effectiveness of such cross-lingual evaluation in low resource scenarios. Further, it is also effective in zero-shot evaluation on unseen languages. This study is the first comprehensive examination of cross-lingual evaluation using LLMs, presenting a scalable and effective approach for multilingual assessment. All code, datasets, and models will be publicly available to enable further research in this important area.

  • 6 authors
·
Oct 17, 2024 2

SciVisAgentBench: A Benchmark for Evaluating Scientific Data Analysis and Visualization Agents

Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.

  • 16 authors
·
Mar 30

Experts' cognition-driven ensemble deep learning for external validation of predicting pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

In breast cancer imaging, there has been a trend to directly predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) from histological images based on deep learning (DL). However, it has been a commonly known problem that the constructed DL-based models numerically have better performances in internal validation than in external validation. The primary reason for this situation lies in that the distribution of the external data for validation is different from the distribution of the training data for the construction of the predictive model. In this paper, we aim to alleviate this situation with a more intrinsic approach. We propose an experts' cognition-driven ensemble deep learning (ECDEDL) approach for external validation of predicting pCR to NAC from histological images in breast cancer. The proposed ECDEDL, which takes the cognition of both pathology and artificial intelligence experts into consideration to improve the generalization of the predictive model to the external validation, more intrinsically approximates the working paradigm of a human being which will refer to his various working experiences to make decisions. The proposed ECDEDL approach was validated with 695 WSIs collected from the same center as the primary dataset to develop the predictive model and perform the internal validation, and 340 WSIs collected from other three centers as the external dataset to perform the external validation. In external validation, the proposed ECDEDL approach improves the AUCs of pCR prediction from 61.52(59.80-63.26) to 67.75(66.74-68.80) and the Accuracies of pCR prediction from 56.09(49.39-62.79) to 71.01(69.44-72.58). The proposed ECDEDL was quite effective for external validation, numerically more approximating the internal validation.

  • 7 authors
·
Jun 19, 2023

Mediocrity is the key for LLM as a Judge Anchor Selection

The ``LLM-as-a-judge'' paradigm has become a standard method for evaluating open-ended generation. To address the quadratic scalability costs of pairwise comparisons, popular benchmarks like Arena-Hard and AlpacaEval compare all models against a single anchor. However, despite its widespread use, the impact of anchor selection on the reliability of the results remains largely unexplored. In this work, we systematically investigate the effect of anchor selection by evaluating 22 different anchors on the Arena-Hard-v2.0 dataset. We find that the choice of anchor is critical: a poor anchor can dramatically reduce correlation with human rankings. We identify that common anchor choices (best-performing and worst-performing models) make poor anchors. Because these extreme anchors are consistently better or worse than all other models, they are seldom indicative of the relative ranking of the models. We further quantify the effect size of anchor selection, showing it is comparable to the selection of a judge model. We conclude with actionable recommendations. First, we conduct a power analysis, and compute sufficient benchmark sizes for anchor-based evaluation, finding that standard benchmark sizes are insufficient for pairwise evaluation and fail to distinguish between competitive models reliably. Second, we provide guidelines for selecting informative anchors to ensure reliable and efficient evaluation practices.

  • 4 authors
·
Mar 17

Any Large Language Model Can Be a Reliable Judge: Debiasing with a Reasoning-based Bias Detector

LLM-as-a-Judge has emerged as a promising tool for automatically evaluating generated outputs, but its reliability is often undermined by potential biases in judgment. Existing efforts to mitigate these biases face key limitations: in-context learning-based methods fail to address rooted biases due to the evaluator's limited capacity for self-reflection, whereas fine-tuning is not applicable to all evaluator types, especially closed-source models. To address this challenge, we introduce the Reasoning-based Bias Detector (RBD), which is a plug-in module that identifies biased evaluations and generates structured reasoning to guide evaluator self-correction. Rather than modifying the evaluator itself, RBD operates externally and engages in an iterative process of bias detection and feedback-driven revision. To support its development, we design a complete pipeline consisting of biased dataset construction, supervision collection, distilled reasoning-based fine-tuning of RBD, and integration with LLM evaluators. We fine-tune four sizes of RBD models, ranging from 1.5B to 14B, and observe consistent performance improvements across all scales. Experimental results on 4 bias types--verbosity, position, bandwagon, and sentiment--evaluated using 8 LLM evaluators demonstrate RBD's strong effectiveness. For example, the RBD-8B model improves evaluation accuracy by an average of 18.5% and consistency by 10.9%, and surpasses prompting-based baselines and fine-tuned judges by 12.8% and 17.2%, respectively. These results highlight RBD's effectiveness and scalability. Additional experiments further demonstrate its strong generalization across biases and domains, as well as its efficiency.

  • 7 authors
·
May 21, 2025

SCOPE-MRI: Bankart Lesion Detection as a Case Study in Data Curation and Deep Learning for Challenging Diagnoses

Deep learning has shown strong performance in musculoskeletal imaging, but prior work has largely targeted conditions where diagnosis is relatively straightforward. More challenging problems remain underexplored, such as detecting Bankart lesions (anterior-inferior glenoid labral tears) on standard MRIs. These lesions are difficult to diagnose due to subtle imaging features, often necessitating invasive MRI arthrograms (MRAs). We introduce ScopeMRI, the first publicly available, expert-annotated dataset for shoulder pathologies, and present a deep learning framework for Bankart lesion detection on both standard MRIs and MRAs. ScopeMRI contains shoulder MRIs from patients who underwent arthroscopy, providing ground-truth labels from intraoperative findings, the diagnostic gold standard. Separate models were trained for MRIs and MRAs using CNN- and transformer-based architectures, with predictions ensembled across multiple imaging planes. Our models achieved radiologist-level performance, with accuracy on standard MRIs surpassing radiologists interpreting MRAs. External validation on independent hospital data demonstrated initial generalizability across imaging protocols. By releasing ScopeMRI and a modular codebase for training and evaluation, we aim to accelerate research in musculoskeletal imaging and foster development of datasets and models that address clinically challenging diagnostic tasks.

  • 7 authors
·
Apr 29, 2025

Multi-LLM Thematic Analysis with Dual Reliability Metrics: Combining Cohen's Kappa and Semantic Similarity for Qualitative Research Validation

Qualitative research faces a critical reliability challenge: traditional inter-rater agreement methods require multiple human coders, are time-intensive, and often yield moderate consistency. We present a multi-perspective validation framework for LLM-based thematic analysis that combines ensemble validation with dual reliability metrics: Cohen's Kappa (κ) for inter-rater agreement and cosine similarity for semantic consistency. Our framework enables configurable analysis parameters (1-6 seeds, temperature 0.0-2.0), supports custom prompt structures with variable substitution, and provides consensus theme extraction across any JSON format. As proof-of-concept, we evaluate three leading LLMs (Gemini 2.5 Pro, GPT-4o, Claude 3.5 Sonnet) on a psychedelic art therapy interview transcript, conducting six independent runs per model. Results demonstrate Gemini achieves highest reliability (κ= 0.907, cosine=95.3%), followed by GPT-4o (κ= 0.853, cosine=92.6%) and Claude (κ= 0.842, cosine=92.1%). All three models achieve a high agreement (κ> 0.80), validating the multi-run ensemble approach. The framework successfully extracts consensus themes across runs, with Gemini identifying 6 consensus themes (50-83% consistency), GPT-4o identifying 5 themes, and Claude 4 themes. Our open-source implementation provides researchers with transparent reliability metrics, flexible configuration, and structure-agnostic consensus extraction, establishing methodological foundations for reliable AI-assisted qualitative research.

YaleUniversity Yale University
·
Dec 23, 2025 2