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Oct 20

BrainTRACE: Tracing Longitudinal, Multimodal, and Volumetric Evidence in Brain MRI Clinical Reasoning

Brain MRI interpretation is a longitudinal clinical reasoning problem: radiologists compare serial studies, integrate information across MRI sequences, localize findings within volumetric anatomy, and translate this evidence into report-grounded assessments. Existing medical VQA and 3D imaging benchmarks capture important parts of this workflow, but often evaluate brain MRI through isolated images, static volumes, or ungrounded report-style answers, thereby obscuring failures in the evidence chain that support clinical validity. We introduce BrainTRACE, a report-grounded benchmark for evaluating whether vision-language models can trace the evidence structure required for longitudinal brain MRI interpretation. BrainTRACE contains 7,273 scored VQA instances derived from 1,778 longitudinal patients, 7,299 MRI studies, and approximately 29k co-registered 3D MRI sequence volumes. The benchmark is organized by five levels of clinical reasoning, from acquisition recognition to case-level synthesis, and by evidence demands covering longitudinal comparison, report-grounded references, multi-sequence integration, and volumetric spatial evidence. BrainTRACE supports rendered inputs compatible with standard VLM interfaces, a 3D-evidence condition, and a decomposed case-reasoning track that audits six steps in a longitudinal evidence chain. Evaluation of 20 VLM configurations shows that current systems can identify isolated visual cues but rarely compose them into grounded longitudinal interpretations. We release the benchmark specification, evaluation lists, scoring implementation, scoring rubrics, and audit-record format to support reproducible progress in brain MRI VLM evaluation.

  • 8 authors
·
Oct 4

Network Representation of Large-Scale Heterogeneous RNA Sequences with Integration of Diverse Multi-omics, Interactions, and Annotations Data

Long non-coding RNA, microRNA, and messenger RNA enable key regulations of various biological processes through a variety of diverse interaction mechanisms. Identifying the interactions and cross-talk between these heterogeneous RNA classes is essential in order to uncover the functional role of individual RNA transcripts, especially for unannotated and newly-discovered RNA sequences with no known interactions. Recently, sequence-based deep learning and network embedding methods are becoming promising approaches that can either predict RNA-RNA interactions from a sequence or infer missing interactions from patterns that may exist in the network topology. However, the majority of these methods have several limitations, eg, the inability to perform inductive predictions, to distinguish the directionality of interactions, or to integrate various sequence, interaction, and annotation biological datasets. We proposed a novel deep learning-based framework, rna2rna, which learns from RNA sequences to produce a low-dimensional embedding that preserves the proximities in both the interactions topology and the functional affinity topology. In this proposed embedding space, we have designated a two-part" source and target contexts" to capture the targeting and receptive fields of each RNA transcript, while encapsulating the heterogenous cross-talk interactions between lncRNAs and miRNAs. From experimental results, our method exhibits superior performance in AUPR rates compared to state-of-art approaches at predicting missing interactions in different RNA-RNA interaction databases and was shown to accurately perform link predictions to novel RNA sequences not seen at training time, even without any prior information. Additional results suggest that our proposed framework can capture a manifold for heterogeneous RNA sequences to discover novel functional annotations.

  • 2 authors
·
Dec 7, 2020

InfiMed-Foundation: Pioneering Advanced Multimodal Medical Models with Compute-Efficient Pre-Training and Multi-Stage Fine-Tuning

Multimodal large language models (MLLMs) have shown remarkable potential in various domains, yet their application in the medical field is hindered by several challenges. General-purpose MLLMs often lack the specialized knowledge required for medical tasks, leading to uncertain or hallucinatory responses. Knowledge distillation from advanced models struggles to capture domain-specific expertise in radiology and pharmacology. Additionally, the computational cost of continual pretraining with large-scale medical data poses significant efficiency challenges. To address these issues, we propose InfiMed-Foundation-1.7B and InfiMed-Foundation-4B, two medical-specific MLLMs designed to deliver state-of-the-art performance in medical applications. We combined high-quality general-purpose and medical multimodal data and proposed a novel five-dimensional quality assessment framework to curate high-quality multimodal medical datasets. We employ low-to-high image resolution and multimodal sequence packing to enhance training efficiency, enabling the integration of extensive medical data. Furthermore, a three-stage supervised fine-tuning process ensures effective knowledge extraction for complex medical tasks. Evaluated on the MedEvalKit framework, InfiMed-Foundation-1.7B outperforms Qwen2.5VL-3B, while InfiMed-Foundation-4B surpasses HuatuoGPT-V-7B and MedGemma-27B-IT, demonstrating superior performance in medical visual question answering and diagnostic tasks. By addressing key challenges in data quality, training efficiency, and domain-specific knowledge extraction, our work paves the way for more reliable and effective AI-driven solutions in healthcare. InfiMed-Foundation-4B model is available at https://huggingface.co/InfiX-ai/InfiMed-Foundation-4B{InfiMed-Foundation-4B}.

  • 6 authors
·
Sep 26, 2025

Bidirectional Hierarchical Protein Multi-Modal Representation Learning

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based tasks. However, pLMs lack structural context. Conversely, graph neural networks (GNNs) designed to leverage 3D structural information have shown promising generalization in protein-related prediction tasks, but their effectiveness is often constrained by the scarcity of labeled structural data. Recognizing that sequence and structural representations are complementary perspectives of the same protein entity, we propose a multimodal bidirectional hierarchical fusion framework to effectively merge these modalities. Our framework employs attention and gating mechanisms to enable effective interaction between pLMs-generated sequential representations and GNN-extracted structural features, improving information exchange and enhancement across layers of the neural network. This bidirectional and hierarchical (Bi-Hierarchical) fusion approach leverages the strengths of both modalities to capture richer and more comprehensive protein representations. Based on the framework, we further introduce local Bi-Hierarchical Fusion with gating and global Bi-Hierarchical Fusion with multihead self-attention approaches. Our method demonstrates consistent improvements over strong baselines and existing fusion techniques in a variety of protein representation learning benchmarks, including enzyme EC classification, model quality assessment, protein-ligand binding affinity prediction, protein-protein binding site prediction, and B cell epitopes prediction. Our method establishes a new state-of-the-art for multimodal protein representation learning, emphasizing the efficacy of Bi-Hierarchical Fusion in bridging sequence and structural modalities.

  • 5 authors
·
Apr 7, 2025

ProtST: Multi-Modality Learning of Protein Sequences and Biomedical Texts

Current protein language models (PLMs) learn protein representations mainly based on their sequences, thereby well capturing co-evolutionary information, but they are unable to explicitly acquire protein functions, which is the end goal of protein representation learning. Fortunately, for many proteins, their textual property descriptions are available, where their various functions are also described. Motivated by this fact, we first build the ProtDescribe dataset to augment protein sequences with text descriptions of their functions and other important properties. Based on this dataset, we propose the ProtST framework to enhance Protein Sequence pre-training and understanding by biomedical Texts. During pre-training, we design three types of tasks, i.e., unimodal mask prediction, multimodal representation alignment and multimodal mask prediction, to enhance a PLM with protein property information with different granularities and, at the same time, preserve the PLM's original representation power. On downstream tasks, ProtST enables both supervised learning and zero-shot prediction. We verify the superiority of ProtST-induced PLMs over previous ones on diverse representation learning benchmarks. Under the zero-shot setting, we show the effectiveness of ProtST on zero-shot protein classification, and ProtST also enables functional protein retrieval from a large-scale database without any function annotation.

  • 4 authors
·
Jan 27, 2023

Scaling RL to Long Videos

We introduce a full-stack framework that scales up reasoning in vision-language models (VLMs) to long videos, leveraging reinforcement learning. We address the unique challenges of long video reasoning by integrating three critical components: (1) a large-scale dataset, LongVideo-Reason, comprising 52K long video QA pairs with high-quality reasoning annotations across diverse domains such as sports, games, and vlogs; (2) a two-stage training pipeline that extends VLMs with chain-of-thought supervised fine-tuning (CoT-SFT) and reinforcement learning (RL); and (3) a training infrastructure for long video RL, named Multi-modal Reinforcement Sequence Parallelism (MR-SP), which incorporates sequence parallelism and a vLLM-based engine tailored for long video, using cached video embeddings for efficient rollout and prefilling. In experiments, LongVILA-R1-7B achieves strong performance on long video QA benchmarks such as VideoMME. It also outperforms Video-R1-7B and even matches Gemini-1.5-Pro across temporal reasoning, goal and purpose reasoning, spatial reasoning, and plot reasoning on our LongVideo-Reason-eval benchmark. Notably, our MR-SP system achieves up to 2.1x speedup on long video RL training. LongVILA-R1 demonstrates consistent performance gains as the number of input video frames scales. LongVILA-R1 marks a firm step towards long video reasoning in VLMs. In addition, we release our training system for public availability that supports RL training on various modalities (video, text, and audio), various models (VILA and Qwen series), and even image and video generation models. On a single A100 node (8 GPUs), it supports RL training on hour-long videos (e.g., 3,600 frames / around 256k tokens).

  • 14 authors
·
Jul 10, 2025 4

DriveMotion: A Large-Scale Multi-Source Benchmark for Driver Motion Sequence Modeling and Forecasting

Driver motion can provide cues to ongoing behavior, attention, and near-term driving intent. However, most existing driver-centric datasets focus on recognizing predefined driver behaviors from short video clips, while human motion forecasting benchmarks largely target motion outside the vehicle. We introduce DriveMotion, a multi-source benchmark for continuous driver motion forecasting. DriveMotion contains 393 hours of 133-keypoint motion sequences at 10 Hz from 360 drivers, integrating naturalistic driving data, curated public in-cabin videos, and the AIDE dataset into a unified representation with per-joint validity masks and synchronized driving context. Naturalistic driving contains long periods of limited body movement, making uniformly sampled evaluation dominated by persistence and less sensitive to brief but behaviorally meaningful motion. To address this, we use dynamics-anchored evaluation, placing forecasting windows around vehicle maneuvers identified offline from CAN signals without providing CAN to the model at inference. Arm motion in pre-maneuver windows is 3.4x greater than in route-matched stable-driving controls. On these anchored windows, learned models reduce forecasting error over persistence by up to 15%, while maneuver-enriched training improves forecast-derived Part-State F1 by 44% over the zero-motion reference. Training on the full multi-source corpus further reduces forecasting error on held-out web drivers by 38% compared with BATON-only training. DriveMotion provides identity-disjoint splits, fixed evaluation subsets, and reference implementations for reproducible evaluation of continuous driver motion forecasting. The dataset and benchmark are available at https://huggingface.co/datasets/HenryYHW/DriveMotion

  • 5 authors
·
Sep 7

Unified Generative and Discriminative Training for Multi-modal Large Language Models

In recent times, Vision-Language Models (VLMs) have been trained under two predominant paradigms. Generative training has enabled Multimodal Large Language Models (MLLMs) to tackle various complex tasks, yet issues such as hallucinations and weak object discrimination persist. Discriminative training, exemplified by models like CLIP, excels in zero-shot image-text classification and retrieval, yet struggles with complex scenarios requiring fine-grained semantic differentiation. This paper addresses these challenges by proposing a unified approach that integrates the strengths of both paradigms. Considering interleaved image-text sequences as the general format of input samples, we introduce a structure-induced training strategy that imposes semantic relationships between input samples and the MLLM's hidden state. This approach enhances the MLLM's ability to capture global semantics and distinguish fine-grained semantics. By leveraging dynamic sequence alignment within the Dynamic Time Warping framework and integrating a novel kernel for fine-grained semantic differentiation, our method effectively balances generative and discriminative tasks. Extensive experiments demonstrate the effectiveness of our approach, achieving state-of-the-art results in multiple generative tasks, especially those requiring cognitive and discrimination abilities. Additionally, our method surpasses discriminative benchmarks in interleaved and fine-grained retrieval tasks. By employing a retrieval-augmented generation strategy, our approach further enhances performance in some generative tasks within one model, offering a promising direction for future research in vision-language modeling.

  • 10 authors
·
Oct 31, 2024

HTR-JAND: Handwritten Text Recognition with Joint Attention Network and Knowledge Distillation

Despite significant advances in deep learning, current Handwritten Text Recognition (HTR) systems struggle with the inherent complexity of historical documents, including diverse writing styles, degraded text quality, and computational efficiency requirements across multiple languages and time periods. This paper introduces HTR-JAND (HTR-JAND: Handwritten Text Recognition with Joint Attention Network and Knowledge Distillation), an efficient HTR framework that combines advanced feature extraction with knowledge distillation. Our architecture incorporates three key components: (1) a CNN architecture integrating FullGatedConv2d layers with Squeeze-and-Excitation blocks for adaptive feature extraction, (2) a Combined Attention mechanism fusing Multi-Head Self-Attention with Proxima Attention for robust sequence modeling, and (3) a Knowledge Distillation framework enabling efficient model compression while preserving accuracy through curriculum-based training. The HTR-JAND framework implements a multi-stage training approach combining curriculum learning, synthetic data generation, and multi-task learning for cross-dataset knowledge transfer. We enhance recognition accuracy through context-aware T5 post-processing, particularly effective for historical documents. Comprehensive evaluations demonstrate HTR-JAND's effectiveness, achieving state-of-the-art Character Error Rates (CER) of 1.23\%, 1.02\%, and 2.02\% on IAM, RIMES, and Bentham datasets respectively. Our Student model achieves a 48\% parameter reduction (0.75M versus 1.5M parameters) while maintaining competitive performance through efficient knowledge transfer. Source code and pre-trained models are available at https://github.com/DocumentRecognitionModels/HTR-JAND{Github}.

  • 3 authors
·
Dec 24, 2024

Capturing More: Learning Multi-Domain Representations for Robust Online Handwriting Verification

In this paper, we propose SPECTRUM, a temporal-frequency synergistic model that unlocks the untapped potential of multi-domain representation learning for online handwriting verification (OHV). SPECTRUM comprises three core components: (1) a multi-scale interactor that finely combines temporal and frequency features through dual-modal sequence interaction and multi-scale aggregation, (2) a self-gated fusion module that dynamically integrates global temporal and frequency features via self-driven balancing. These two components work synergistically to achieve micro-to-macro spectral-temporal integration. (3) A multi-domain distance-based verifier then utilizes both temporal and frequency representations to improve discrimination between genuine and forged handwriting, surpassing conventional temporal-only approaches. Extensive experiments demonstrate SPECTRUM's superior performance over existing OHV methods, underscoring the effectiveness of temporal-frequency multi-domain learning. Furthermore, we reveal that incorporating multiple handwritten biometrics fundamentally enhances the discriminative power of handwriting representations and facilitates verification. These findings not only validate the efficacy of multi-domain learning in OHV but also pave the way for future research in multi-domain approaches across both feature and biometric domains. Code is publicly available at https://github.com/NiceRingNode/SPECTRUM.

  • 3 authors
·
Aug 2, 2025

Life-Code: Central Dogma Modeling with Multi-Omics Sequence Unification

The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains underexplored. This paper follows the guidance of the central dogma to redesign both the data and model pipeline and offers a comprehensive framework, Life-Code, that spans different biological functions. As for data flow, we propose a unified pipeline to integrate multi-omics data by reverse-transcribing RNA and reverse-translating amino acids into nucleotide-based sequences. As for the model, we design a codon tokenizer and a hybrid long-sequence architecture to encode the interactions between coding and non-coding regions through masked modeling pre-training. To model the translation and folding process with coding sequences, Life-Code learns protein structures of the corresponding amino acids by knowledge distillation from off-the-shelf protein language models. Such designs enable Life-Code to capture complex interactions within genetic sequences, providing a more comprehensive understanding of multi-omics with the central dogma. Extensive experiments show that Life-Code achieves state-of-the-art results on various tasks across three omics, highlighting its potential for advancing multi-omics analysis and interpretation.

  • 10 authors
·
Feb 11, 2025

Pre-training Generative Recommender with Multi-Identifier Item Tokenization

Generative recommendation autoregressively generates item identifiers to recommend potential items. Existing methods typically adopt a one-to-one mapping strategy, where each item is represented by a single identifier. However, this scheme poses issues, such as suboptimal semantic modeling for low-frequency items and limited diversity in token sequence data. To overcome these limitations, we propose MTGRec, which leverages Multi-identifier item Tokenization to augment token sequence data for Generative Recommender pre-training. Our approach involves two key innovations: multi-identifier item tokenization and curriculum recommender pre-training. For multi-identifier item tokenization, we leverage the RQ-VAE as the tokenizer backbone and treat model checkpoints from adjacent training epochs as semantically relevant tokenizers. This allows each item to be associated with multiple identifiers, enabling a single user interaction sequence to be converted into several token sequences as different data groups. For curriculum recommender pre-training, we introduce a curriculum learning scheme guided by data influence estimation, dynamically adjusting the sampling probability of each data group during recommender pre-training. After pre-training, we fine-tune the model using a single tokenizer to ensure accurate item identification for recommendation. Extensive experiments on three public benchmark datasets demonstrate that MTGRec significantly outperforms both traditional and generative recommendation baselines in terms of effectiveness and scalability.

  • 7 authors
·
May 24, 2025

Insertion Language Models: Sequence Generation with Arbitrary-Position Insertions

Autoregressive models (ARMs), which predict subsequent tokens one-by-one ``from left to right,'' have achieved significant success across a wide range of sequence generation tasks. However, they struggle to accurately represent sequences that require satisfying sophisticated constraints or whose sequential dependencies are better addressed by out-of-order generation. Masked Diffusion Models (MDMs) address some of these limitations, but the process of unmasking multiple tokens simultaneously in MDMs can introduce incoherences, and MDMs cannot handle arbitrary infilling constraints when the number of tokens to be filled in is not known in advance. In this work, we introduce Insertion Language Models (ILMs), which learn to insert tokens at arbitrary positions in a sequence -- that is, they select jointly both the position and the vocabulary element to be inserted. By inserting tokens one at a time, ILMs can represent strong dependencies between tokens, and their ability to generate sequences in arbitrary order allows them to accurately model sequences where token dependencies do not follow a left-to-right sequential structure. To train ILMs, we propose a tailored network parameterization and use a simple denoising objective. Our empirical evaluation demonstrates that ILMs outperform both ARMs and MDMs on common planning tasks. Furthermore, we show that ILMs outperform MDMs and perform on par with ARMs in an unconditional text generation task while offering greater flexibility than MDMs in arbitrary-length text infilling.

  • 6 authors
·
May 8, 2025

JustDense: Just using Dense instead of Sequence Mixer for Time Series analysis

Sequence and channel mixers, the core mechanism in sequence models, have become the de facto standard in time series analysis (TSA). However, recent studies have questioned the necessity of complex sequence mixers, such as attention mechanisms, demonstrating that simpler architectures can achieve comparable or even superior performance. This suggests that the benefits attributed to complex sequencemixers might instead emerge from other architectural or optimization factors. Based on this observation, we pose a central question: Are common sequence mixers necessary for time-series analysis? Therefore, we propose JustDense, an empirical study that systematically replaces sequence mixers in various well-established TSA models with dense layers. Grounded in the MatrixMixer framework, JustDense treats any sequence mixer as a mixing matrix and replaces it with a dense layer. This substitution isolates the mixing operation, enabling a clear theoretical foundation for understanding its role. Therefore, we conducted extensive experiments on 29 benchmarks covering five representative TSA tasks using seven state-of-the-art TSA models to address our research question. The results show that replacing sequence mixers with dense layers yields comparable or even superior performance. In the cases where dedicated sequence mixers still offer benefits, JustDense challenges the assumption that "deeper and more complex architectures are inherently better" in TSA.

Multi-resolution Networks For Flexible Irregular Time Series Modeling (Multi-FIT)

Missing values, irregularly collected samples, and multi-resolution signals commonly occur in multivariate time series data, making predictive tasks difficult. These challenges are especially prevalent in the healthcare domain, where patients' vital signs and electronic records are collected at different frequencies and have occasionally missing information due to the imperfections in equipment or patient circumstances. Researchers have handled each of these issues differently, often handling missing data through mean value imputation and then using sequence models over the multivariate signals while ignoring the different resolution of signals. We propose a unified model named Multi-resolution Flexible Irregular Time series Network (Multi-FIT). The building block for Multi-FIT is the FIT network. The FIT network creates an informative dense representation at each time step using signal information such as last observed value, time difference since the last observed time stamp and overall mean for the signal. Vertical FIT (FIT-V) is a variant of FIT which also models the relationship between different temporal signals while creating the informative dense representations for the signal. The multi-FIT model uses multiple FIT networks for sets of signals with different resolutions, further facilitating the construction of flexible representations. Our model has three main contributions: a.) it does not impute values but rather creates informative representations to provide flexibility to the model for creating task-specific representations b.) it models the relationship between different signals in the form of support signals c.) it models different resolutions in parallel before merging them for the final prediction task. The FIT, FIT-V and Multi-FIT networks improve upon the state-of-the-art models for three predictive tasks, including the forecasting of patient survival.

  • 7 authors
·
Apr 30, 2019

How Many Heads Make an SSM? A Unified Framework for Attention and State Space Models

Sequence modeling has produced diverse architectures -- from classical recurrent neural networks to modern Transformers and state space models (SSMs) -- yet a unified theoretical understanding of expressivity and trainability trade-offs remains limited. We introduce a unified framework that represents a broad class of sequence maps via an input-dependent effective interaction operator W_{ij}(X), making explicit two recurring construction patterns: (i) the Unified Factorized Framework (Explicit) (attention-style mixing), in which W_{ij}(X) varies through scalar coefficients applied to shared value maps, and (ii) Structured Dynamics (Implicit) (state-space recurrences), in which W_{ij} is induced by a latent dynamical system. Using this framework, we derive three theoretical results. First, we establish the Interaction Rank Gap: models in the Unified Factorized Framework, such as single-head attention, are constrained to a low-dimensional operator span and cannot represent certain structured dynamical maps. Second, we prove an Equivalence (Head-Count) Theorem showing that, within our multi-head factorized class, representing a linear SSM whose lag operators span a k-dimensional subspace on length-n sequences requires and is achievable with H=k heads. Third, we prove a Gradient Highway Result, showing that attention layers admit inputs with distance-independent gradient paths, whereas stable linear dynamics exhibit distance-dependent gradient attenuation. Together, these results formalize a fundamental trade-off between algebraic expressivity (interaction/operator span) and long-range gradient propagation, providing theoretical grounding for modern sequence architecture design.

  • 1 authors
·
Dec 17, 2025

Hydra: Bidirectional State Space Models Through Generalized Matrix Mixers

A wide array of sequence models are built on a framework modeled after Transformers, comprising alternating sequence mixer and channel mixer layers. This paper studies a unifying matrix mixer view of sequence mixers that can be conceptualized as a linear map on the input sequence. This framework encompasses a broad range of well-known sequence models, including the self-attention of Transformers as well as recent strong alternatives such as structured state space models (SSMs), and allows understanding downstream characteristics such as efficiency and expressivity through properties of their structured matrix class. We identify a key axis of matrix parameterizations termed sequence alignment, which increases the flexibility and performance of matrix mixers, providing insights into the strong performance of Transformers and recent SSMs such as Mamba. Furthermore, the matrix mixer framework offers a systematic approach to developing sequence mixers with desired properties, allowing us to develop several new sub-quadratic sequence models. In particular, we propose a natural bidirectional extension of the Mamba model (Hydra), parameterized as a quasiseparable matrix mixer, which demonstrates superior performance over other sequence models including Transformers on non-causal tasks. As a drop-in replacement for attention layers, Hydra outperforms BERT by 0.8 points on the GLUE benchmark and ViT by 2% Top-1 accuracy on ImageNet.

  • 4 authors
·
Jul 13, 2024

M4V: Multimodal Mamba for Efficient Text-to-Video Generation

Text-to-video generation has significantly enriched content creation and holds the potential to evolve into powerful world simulators. However, modeling the vast spatiotemporal space remains computationally demanding, particularly when employing Transformers, which incur quadratic complexity in sequence processing and thus limit practical applications. Recent advancements in linear-time sequence modeling, particularly the Mamba architecture, offer a more efficient alternative. Nevertheless, its plain design limits its direct applicability to multimodal and spatiotemporal video generation tasks. To address these challenges, we introduce M4V, a multimodal Mamba framework for efficient text-to-video generation. Specifically, a MultiModal diffusion Mamba (MM-DiM) block is designed within the framework to enable seamless integration of multimodal information and spatiotemporal modeling. In detail, we introduce a novel multimodal token re-composition design, which employs a bidirectional scheme for multimodal information integration through simple token arrangement, along with visual registers to enhance spatialtemporal consistency. As a result, the MM-DiM blocks in M4V reduce FLOPs by 45% compared with the attention-based alternative when generating videos at 768x1280 resolution. Additionally, several training strategies are explored in this work to provide a better understanding of training text-to-video models using only publicly available datasets. Extensive experiments on text-to-video benchmarks demonstrate M4V's ability to produce high-quality videos while significantly lowering computational costs. Project page: https://huangjch526.github.io/M4V_project/.

  • 8 authors
·
Jul 9

UniRec: A Dual Enhancement of Uniformity and Frequency in Sequential Recommendations

Representation learning in sequential recommendation is critical for accurately modeling user interaction patterns and improving recommendation precision. However, existing approaches predominantly emphasize item-to-item transitions, often neglecting the time intervals between interactions, which are closely related to behavior pattern changes. Additionally, broader interaction attributes, such as item frequency, are frequently overlooked. We found that both sequences with more uniform time intervals and items with higher frequency yield better prediction performance. Conversely, non-uniform sequences exacerbate user interest drift and less-frequent items are difficult to model due to sparse sampling, presenting unique challenges inadequately addressed by current methods. In this paper, we propose UniRec, a novel bidirectional enhancement sequential recommendation method. UniRec leverages sequence uniformity and item frequency to enhance performance, particularly improving the representation of non-uniform sequences and less-frequent items. These two branches mutually reinforce each other, driving comprehensive performance optimization in complex sequential recommendation scenarios. Additionally, we present a multidimensional time module to further enhance adaptability. To the best of our knowledge, UniRec is the first method to utilize the characteristics of uniformity and frequency for feature augmentation. Comparing with eleven advanced models across four datasets, we demonstrate that UniRec outperforms SOTA models significantly. The code is available at https://github.com/Linxi000/UniRec.

  • 3 authors
·
Jun 26, 2024

Mamba-360: Survey of State Space Models as Transformer Alternative for Long Sequence Modelling: Methods, Applications, and Challenges

Sequence modeling is a crucial area across various domains, including Natural Language Processing (NLP), speech recognition, time series forecasting, music generation, and bioinformatics. Recurrent Neural Networks (RNNs) and Long Short Term Memory Networks (LSTMs) have historically dominated sequence modeling tasks like Machine Translation, Named Entity Recognition (NER), etc. However, the advancement of transformers has led to a shift in this paradigm, given their superior performance. Yet, transformers suffer from O(N^2) attention complexity and challenges in handling inductive bias. Several variations have been proposed to address these issues which use spectral networks or convolutions and have performed well on a range of tasks. However, they still have difficulty in dealing with long sequences. State Space Models(SSMs) have emerged as promising alternatives for sequence modeling paradigms in this context, especially with the advent of S4 and its variants, such as S4nd, Hippo, Hyena, Diagnol State Spaces (DSS), Gated State Spaces (GSS), Linear Recurrent Unit (LRU), Liquid-S4, Mamba, etc. In this survey, we categorize the foundational SSMs based on three paradigms namely, Gating architectures, Structural architectures, and Recurrent architectures. This survey also highlights diverse applications of SSMs across domains such as vision, video, audio, speech, language (especially long sequence modeling), medical (including genomics), chemical (like drug design), recommendation systems, and time series analysis, including tabular data. Moreover, we consolidate the performance of SSMs on benchmark datasets like Long Range Arena (LRA), WikiText, Glue, Pile, ImageNet, Kinetics-400, sstv2, as well as video datasets such as Breakfast, COIN, LVU, and various time series datasets. The project page for Mamba-360 work is available on this webpage.https://github.com/badripatro/mamba360.

  • 2 authors
·
Apr 24, 2024 1

Reinforcement Learning for Adaptive Time-Stepping in the Chaotic Gravitational Three-Body Problem

Many problems in astrophysics cover multiple orders of magnitude in spatial and temporal scales. While simulating systems that experience rapid changes in these conditions, it is essential to adapt the (time-) step size to capture the behavior of the system during those rapid changes and use a less accurate time step at other, less demanding, moments. We encounter three problems with traditional methods. Firstly, making such changes requires expert knowledge of the astrophysics as well as of the details of the numerical implementation. Secondly, some parameters that determine the time-step size are fixed throughout the simulation, which means that they do not adapt to the rapidly changing conditions of the problem. Lastly, we would like the choice of time-step size to balance accuracy and computation effort. We address these challenges with Reinforcement Learning by training it to select the time-step size dynamically. We use the integration of a system of three equal-mass bodies that move due to their mutual gravity as an example of its application. With our method, the selected integration parameter adapts to the specific requirements of the problem, both in terms of computation time and accuracy while eliminating the expert knowledge needed to set up these simulations. Our method produces results competitive to existing methods and improve the results found with the most commonly-used values of time-step parameter. This method can be applied to other integrators without further retraining. We show that this extrapolation works for variable time-step integrators but does not perform to the desired accuracy for fixed time-step integrators.

  • 2 authors
·
Feb 18, 2025

Efficiently Modeling Long Sequences with Structured State Spaces

A central goal of sequence modeling is designing a single principled model that can address sequence data across a range of modalities and tasks, particularly on long-range dependencies. Although conventional models including RNNs, CNNs, and Transformers have specialized variants for capturing long dependencies, they still struggle to scale to very long sequences of 10000 or more steps. A promising recent approach proposed modeling sequences by simulating the fundamental state space model (SSM) \( x'(t) = Ax(t) + Bu(t), y(t) = Cx(t) + Du(t) \), and showed that for appropriate choices of the state matrix \( A \), this system could handle long-range dependencies mathematically and empirically. However, this method has prohibitive computation and memory requirements, rendering it infeasible as a general sequence modeling solution. We propose the Structured State Space sequence model (S4) based on a new parameterization for the SSM, and show that it can be computed much more efficiently than prior approaches while preserving their theoretical strengths. Our technique involves conditioning \( A \) with a low-rank correction, allowing it to be diagonalized stably and reducing the SSM to the well-studied computation of a Cauchy kernel. S4 achieves strong empirical results across a diverse range of established benchmarks, including (i) 91\% accuracy on sequential CIFAR-10 with no data augmentation or auxiliary losses, on par with a larger 2-D ResNet, (ii) substantially closing the gap to Transformers on image and language modeling tasks, while performing generation 60times faster (iii) SoTA on every task from the Long Range Arena benchmark, including solving the challenging Path-X task of length 16k that all prior work fails on, while being as efficient as all competitors.

  • 3 authors
·
Oct 30, 2021

Multi-Modal Experience Inspired AI Creation

AI creation, such as poem or lyrics generation, has attracted increasing attention from both industry and academic communities, with many promising models proposed in the past few years. Existing methods usually estimate the outputs based on single and independent visual or textual information. However, in reality, humans usually make creations according to their experiences, which may involve different modalities and be sequentially correlated. To model such human capabilities, in this paper, we define and solve a novel AI creation problem based on human experiences. More specifically, we study how to generate texts based on sequential multi-modal information. Compared with the previous works, this task is much more difficult because the designed model has to well understand and adapt the semantics among different modalities and effectively convert them into the output in a sequential manner. To alleviate these difficulties, we firstly design a multi-channel sequence-to-sequence architecture equipped with a multi-modal attention network. For more effective optimization, we then propose a curriculum negative sampling strategy tailored for the sequential inputs. To benchmark this problem and demonstrate the effectiveness of our model, we manually labeled a new multi-modal experience dataset. With this dataset, we conduct extensive experiments by comparing our model with a series of representative baselines, where we can demonstrate significant improvements in our model based on both automatic and human-centered metrics. The code and data are available at: https://github.com/Aman-4-Real/MMTG.

  • 6 authors
·
Sep 2, 2022

Looped SSMs: Depth-Recurrence and Input Reshaping for Time Series Classification

State Space Models (SSMs) are inherently recurrent along the sequence dimension, yet depth-recurrence - reusing the same block repeatedly across layers, as recently applied in looped transformers - has not been explored in this model family. We show that a looped SSM with k parameters iterated L times consistently closely matches or outperforms a standard SSM with k cdot L independent parameters across four architectures (LRU, S5, LinOSS, LrcSSM) and six time series classification benchmarks, despite operating within a strictly smaller hypothesis space, as we formally establish. Since the larger model contains the looped model as a special case, this dominance cannot be explained by expressivity and instead points to parameter sharing across depth as a beneficial inductive bias that simplifies optimization. These results demonstrate that depth-recurrence is orthogonal to sequence-recurrence and independently beneficial. We further show that input reshaping is an equally neglected design axis: concatenating timesteps for low-dimensional inputs, or flattening and rechunking the joint feature-time dimension for high-dimensional ones, yields accuracy gains of 1-6% across all models, confirmed over 5 random seeds. Both techniques provide standalone improvements that compound when combined, suggesting that depth and input reshaping are two independent and underexplored design axes for SSMs on time series.

  • 4 authors
·
May 14

Sequence Parallelism: Long Sequence Training from System Perspective

Transformer achieves promising results on various tasks. However, self-attention suffers from quadratic memory requirements with respect to the sequence length. Existing work focuses on reducing time and space complexity from an algorithm perspective. In this work, we propose sequence parallelism, a memory-efficient parallelism method to help us break input sequence length limitation and train with longer sequences on GPUs efficiently. Our approach is compatible with most existing parallelisms (e.g. data parallelism, pipeline parallelism and tensor parallelism), which means our sequence parallelism makes 4D parallelism possible. More importantly, we no longer require a single device to hold the whole sequence. That is, with sparse attention, our sequence parallelism enables us to train transformer with infinite long sequence. Specifically, we split the input sequence into multiple chunks and feed each chunk into its corresponding device (i.e. GPU). To compute the attention output, we integrated ring-style communication with self-attention calculation and proposed Ring Self-Attention (RSA). Experiments show that sequence parallelism performs well when scaling with batch size and sequence length. Compared with tensor parallelism, our approach achieved 13.7times and 3.0times maximum batch size and sequence length respectively when scaling up to 64 NVIDIA P100 GPUs. With sparse attention, sequence can handle sequence with over 114K tokens, which is over 27times longer than existing sparse attention works holding the whole sequence on a single device.

  • 5 authors
·
May 26, 2021

LongVQ: Long Sequence Modeling with Vector Quantization on Structured Memory

Transformer models have been successful in various sequence processing tasks, but the self-attention mechanism's computational cost limits its practicality for long sequences. Although there are existing attention variants that improve computational efficiency, they have a limited ability to abstract global information effectively based on their hand-crafted mixing strategies. On the other hand, state-space models (SSMs) are tailored for long sequences but cannot capture complicated local information. Therefore, the combination of them as a unified token mixer is a trend in recent long-sequence models. However, the linearized attention degrades performance significantly even when equipped with SSMs. To address the issue, we propose a new method called LongVQ. LongVQ uses the vector quantization (VQ) technique to compress the global abstraction as a length-fixed codebook, enabling the linear-time computation of the attention matrix. This technique effectively maintains dynamic global and local patterns, which helps to complement the lack of long-range dependency issues. Our experiments on the Long Range Arena benchmark, autoregressive language modeling, and image and speech classification demonstrate the effectiveness of LongVQ. Our model achieves significant improvements over other sequence models, including variants of Transformers, Convolutions, and recent State Space Models.

  • 6 authors
·
Apr 17, 2024 2

Simultaneous Multi-objective Alignment Across Verifiable and Non-verifiable Rewards

Aligning large language models to human preferences is inherently multidimensional, yet most pipelines collapse heterogeneous signals into a single optimizeable objective. We seek to answer what it would take to simultaneously align a model across various domains spanning those with: verifiable rewards (mathematical accuracy), non-verifiable subjective preferences (human values), and complex interactive scenarios (multi-turn AI tutoring dialogues). Such multi-objective reinforcement learning setups are often plagued by the individual objectives being at odds with each other, resulting in inefficient training and little user control during inference. We propose a unified framework that: (i) standardizes {process reward model} (PRM) training across both verifiable and non-verifiable settings to better supervise models' chain-of-thought reasoning; (ii) performs {multi-objective alignment} by training the LLM with our Multi-Action-Head DPO (MAH-DPO) and a vectorized reward where the dimensions of the vector correspond to the various objectives instead of a single scalar; and (iii) demonstrates how such a system provides fine-grained inference-time user control. Experiments across math reasoning, value alignment, and multi-turn dialogue show that our framework improves performance across multiple objectives simultaneously, while minimizing cross-objective trade-offs and enabling flexible inference time user control. The code can be found at https://github.com/pearls-lab/multiobj-align.

  • 4 authors
·
Oct 1, 2025

SCORE: Replacing Layer Stacking with Contractive Recurrent Depth

Residual connections are central to modern deep neural networks, enabling stable optimization and efficient information flow across depth. In this work, we propose SCORE (Skip-Connection ODE Recurrent Embedding), a discrete recurrent alternative to classical layer stacking. Instead of composing multiple independent layers, SCORE iteratively applies a single shared neural block using an ODE (Ordinary Differential Equation)-inspired contractive update: ht+1 = (1 - dt) * ht + dt * F(ht) This formulation can be interpreted as a depth-by-iteration refinement process, where the step size dt explicitly controls stability and update magnitude. Unlike continuous Neural ODE approaches, SCORE uses a fixed number of discrete iterations and standard backpropagation without requiring ODE solvers or adjoint methods. We evaluate SCORE across graph neural networks (ESOL molecular solubility), multilayer perceptrons, and Transformer-based language models (nanoGPT). Across architectures, SCORE generally improves convergence speed and often accelerates training. SCORE is reducing parameter count through shared weights. In practice, simple Euler integration provides the best trade-off between computational cost and performance, while higher-order integrators yield marginal gains at increased compute. These results suggest that controlled recurrent depth with contractive residual updates offers a lightweight and effective alternative to classical stacking in deep neural networks.

  • 1 authors
·
Mar 11

Real-Time Prediction of Gas Flow Dynamics in Diesel Engines using a Deep Neural Operator Framework

We develop a data-driven deep neural operator framework to approximate multiple output states for a diesel engine and generate real-time predictions with reasonable accuracy. As emission norms become more stringent, the need for fast and accurate models that enable analysis of system behavior have become an essential requirement for system development. The fast transient processes involved in the operation of a combustion engine make it difficult to develop accurate physics-based models for such systems. As an alternative to physics based models, we develop an operator-based regression model (DeepONet) to learn the relevant output states for a mean-value gas flow engine model using the engine operating conditions as input variables. We have adopted a mean-value model as a benchmark for comparison, simulated using Simulink. The developed approach necessitates using the initial conditions of the output states to predict the accurate sequence over the temporal domain. To this end, a sequence-to-sequence approach is embedded into the proposed framework. The accuracy of the model is evaluated by comparing the prediction output to ground truth generated from Simulink model. The maximum mathcal L_2 relative error observed was approximately 6.5%. The sensitivity of the DeepONet model is evaluated under simulated noise conditions and the model shows relatively low sensitivity to noise. The uncertainty in model prediction is further assessed by using a mean ensemble approach. The worst-case error at the (mu + 2sigma) boundary was found to be 12%. The proposed framework provides the ability to predict output states in real-time and enables data-driven learning of complex input-output operator mapping. As a result, this model can be applied during initial development stages, where accurate models may not be available.

  • 4 authors
·
Apr 2, 2023

Exact Diffusion Inversion via Bi-directional Integration Approximation

Recently, various methods have been proposed to address the inconsistency issue of DDIM inversion to enable image editing, such as EDICT [36] and Null-text inversion [22]. However, the above methods introduce considerable computational overhead. In this paper, we propose a new technique, named bi-directional integration approximation (BDIA), to perform exact diffusion inversion with neglible computational overhead. Suppose we would like to estimate the next diffusion state z_{i-1} at timestep t_i with the historical information (i,z_i) and (i+1,z_{i+1}). We first obtain the estimated Gaussian noise boldsymbol{epsilon}(z_i,i), and then apply the DDIM update procedure twice for approximating the ODE integration over the next time-slot [t_i, t_{i-1}] in the forward manner and the previous time-slot [t_i, t_{t+1}] in the backward manner. The DDIM step for the previous time-slot is used to refine the integration approximation made earlier when computing z_i. A nice property of BDIA-DDIM is that the update expression for z_{i-1} is a linear combination of (z_{i+1}, z_i, boldsymbol{epsilon}(z_i,i)). This allows for exact backward computation of z_{i+1} given (z_i, z_{i-1}), thus leading to exact diffusion inversion. It is demonstrated with experiments that (round-trip) BDIA-DDIM is particularly effective for image editing. Our experiments further show that BDIA-DDIM produces markedly better image sampling qualities than DDIM for text-to-image generation. BDIA can also be applied to improve the performance of other ODE solvers in addition to DDIM. In our work, it is found that applying BDIA to the EDM sampling procedure produces consistently better performance over four pre-trained models.

  • 3 authors
·
Jul 10, 2023

Data-Centric and Heterogeneity-Adaptive Sequence Parallelism for Efficient LLM Training

Extending the context length (i.e., the maximum supported sequence length) of LLMs is of paramount significance. To facilitate long context training of LLMs, sequence parallelism has emerged as an essential technique, which scatters each input sequence across multiple devices and necessitates communication to process the sequence. In essence, existing sequence parallelism methods assume homogeneous sequence lengths (i.e., all input sequences are equal in length) and therefore leverages a single, static scattering strategy for all input sequences. However, in reality, the sequence lengths in LLM training corpora exhibit substantial variability, often following a long-tail distribution, which leads to workload heterogeneity. In this paper, we show that employing a single, static strategy results in inefficiency and resource under-utilization, highlighting the need for adaptive approaches to handle the heterogeneous workloads across sequences. To address this, we propose a heterogeneity-adaptive sequence parallelism method. For each training step, our approach captures the variability in sequence lengths and assigns the optimal combination of scattering strategies based on workload characteristics. We model this problem as a linear programming optimization and design an efficient and effective solver to find the optimal solution. Furthermore, we implement our method in a high-performance system that supports adaptive parallelization in distributed LLM training. Experimental results demonstrate that our system outperforms state-of-the-art training frameworks by up to 1.98x.

  • 10 authors
·
Dec 2, 2024

Universal Approximation Theorem for a Single-Layer Transformer

Deep learning employs multi-layer neural networks trained via the backpropagation algorithm. This approach has achieved success across many domains and relies on adaptive gradient methods such as the Adam optimizer. Sequence modeling evolved from recurrent neural networks to attention-based models, culminating in the Transformer architecture. Transformers have achieved state-of-the-art performance in natural language processing (for example, BERT and GPT-3) and have been applied in computer vision and computational biology. However, theoretical understanding of these models remains limited. In this paper, we examine the mathematical foundations of deep learning and Transformers and present a novel theoretical result. We review key concepts from linear algebra, probability, and optimization that underpin deep learning, and we analyze the multi-head self-attention mechanism and the backpropagation algorithm in detail. Our main contribution is a universal approximation theorem for Transformers: we prove that a single-layer Transformer, comprising one self-attention layer followed by a position-wise feed-forward network with ReLU activation, can approximate any continuous sequence-to-sequence mapping on a compact domain to arbitrary precision. We provide a formal statement and a complete proof. Finally, we present case studies that demonstrate the practical implications of this result. Our findings advance the theoretical understanding of Transformer models and help bridge the gap between theory and practice.

  • 1 authors
·
Jul 11, 2025

Multi-Rate Mixture of Experts for Accelerating Liquid Neural Network Training

Multivariate time-series data often exhibit complex temporal dependencies, irregular sampling, and heterogeneous dynamics across multiple time scales, making accurate sequence modeling particularly challenging. Traditional recurrent neural networks (RNNs), such as Long Short-Term Memory (LSTM) networks, operate in discrete time and may struggle to effectively capture continuous and irregular temporal behaviors. Liquid Neural Networks (LNNs) address some of these limitations through continuous-time dynamics, but standard LNN architectures typically rely on a single dynamical system, limiting their ability to model heterogeneous temporal patterns. To address these challenges, we propose a Multi-Rate Mixture-of-Experts (MR-MoE) framework built on top of Liquid Neural Networks. In the proposed architecture, multiple LNN-based experts operate at distinct time scales, enabling the model to explicitly separate fast-changing dynamics from slow-evolving temporal trends. A gating network further enables adaptive expert specialization based on input conditions. In addition, we incorporate both feature-level and temporal attention mechanisms to improve robustness, interpretability, and long-range dependency modeling. Feature-level attention suppresses noisy or irrelevant variables, while temporal attention selectively focuses on informative historical states. We evaluate the proposed framework on a complex multivariate time-series prediction task and compare it against strong baselines, including LSTM, monolithic LNN, and standard MoE models. Experimental results demonstrate that the proposed MR-MoE framework consistently achieves improved AUROC and AUPRC performance while maintaining favorable computational efficiency. These results highlight the effectiveness of combining continuous-time dynamics, multi-scale expert decomposition, and adaptive attention mechanisms for time-series modeling.

  • 3 authors
·
Jun 9

Multiverse: Your Language Models Secretly Decide How to Parallelize and Merge Generation

Autoregressive Large Language Models (AR-LLMs) frequently exhibit implicit parallelism in sequential generation. Inspired by this, we introduce Multiverse, a new generative model that enables natively parallel generation. Multiverse internalizes a MapReduce paradigm, generating automatically through three stages: (i) a Map stage for adaptive task decomposition, (ii) a Process stage for parallel subtask execution, and (iii) a Reduce stage for lossless result synthesis. Next, we build a real-world Multiverse reasoning model with co-design of data, algorithm, and system, enabling rapid and seamless transfer from frontier AR-LLMs. Starting from sequential reasoning chains, we create Multiverse 1K by converting them into structured training data using an automated LLM-assisted pipeline, avoiding costly human annotations. Algorithmically, we design Multiverse Attention to separate parallel reasoning steps while keeping compatibility with causal attention for efficient training. Systematically, we implement Multiverse Engine to enable parallel inference. It features a dedicated scheduler that dynamically switches between sequential and parallel generation, triggered directly by the model. After a 3-hour fine-tuning with 1K examples, our Multiverse-32B stands as the only open-sourced non-AR model achieving performance on par with leading AR-LLMs of the same scale, evidenced by AIME24 & 25 scores of 54% and 46%, respectively. Moreover, our budget control experiments show that Multiverse-32B exhibits superior scaling, outperforming AR-LLMs by 1.87% on average using the same context length. Such scaling further leads to practical efficiency gain, achieving up to 2x speedup across varying batch sizes. We have open-sourced the entire Multiverse ecosystem, including data, model weights, engine, supporting tools, as well as complete data curation prompts and detailed training and evaluation recipes.

  • 5 authors
·
Jun 11, 2025 2

Skywork UniPic 3.0: Unified Multi-Image Composition via Sequence Modeling

The recent surge in popularity of Nano-Banana and Seedream 4.0 underscores the community's strong interest in multi-image composition tasks. Compared to single-image editing, multi-image composition presents significantly greater challenges in terms of consistency and quality, yet existing models have not disclosed specific methodological details for achieving high-quality fusion. Through statistical analysis, we identify Human-Object Interaction (HOI) as the most sought-after category by the community. We therefore systematically analyze and implement a state-of-the-art solution for multi-image composition with a primary focus on HOI-centric tasks. We present Skywork UniPic 3.0, a unified multimodal framework that integrates single-image editing and multi-image composition. Our model supports an arbitrary (1~6) number and resolution of input images, as well as arbitrary output resolutions (within a total pixel budget of 1024x1024). To address the challenges of multi-image composition, we design a comprehensive data collection, filtering, and synthesis pipeline, achieving strong performance with only 700K high-quality training samples. Furthermore, we introduce a novel training paradigm that formulates multi-image composition as a sequence-modeling problem, transforming conditional generation into unified sequence synthesis. To accelerate inference, we integrate trajectory mapping and distribution matching into the post-training stage, enabling the model to produce high-fidelity samples in just 8 steps and achieve a 12.5x speedup over standard synthesis sampling. Skywork UniPic 3.0 achieves state-of-the-art performance on single-image editing benchmark and surpasses both Nano-Banana and Seedream 4.0 on multi-image composition benchmark, thereby validating the effectiveness of our data pipeline and training paradigm. Code, models and dataset are publicly available.

  • 14 authors
·
Jan 22

Large-Scale Multi-omic Biosequence Transformers for Modeling Peptide-Nucleotide Interactions

The transformer architecture has revolutionized bioinformatics and driven progress in the understanding and prediction of the properties of biomolecules. Almost all research on large-scale biosequence transformers has focused on one domain at a time (single-omic), usually nucleotides or peptides. These models have seen incredible success in downstream tasks in each domain and have achieved particularly noteworthy breakthroughs in sequences of peptides and structural modeling. However, these single-omic models are naturally incapable of modeling multi-omic tasks, one of the most biologically critical being nucleotide-peptide interactions. We present our work training the first multi-omic nucleotide-peptide foundation models. We show that these multi-omic models (MOMs) can learn joint representations between various single-omic distributions that are emergently consistent with the Central Dogma of molecular biology, despite only being trained on unlabeled biosequences. We further demonstrate that MOMs can be fine-tuned to achieve state-of-the-art results on peptide-nucleotide interaction tasks, namely predicting the change in Gibbs free energy ({\Delta}G) of the binding interaction between a given oligonucleotide and peptide, as well as the effect on this binding interaction due to mutations in the oligonucleotide sequence ({\Delta}{\Delta}G). Remarkably, we show that multi-omic biosequence transformers emergently learn useful structural information without any prior structural training, allowing us to predict which peptide residues are most involved in the peptide-nucleotide binding interaction. Lastly, we provide evidence that multi-omic biosequence models are non-inferior to foundation models trained on single-omics distributions, suggesting a more generalized or foundational approach to building these models.

  • 5 authors
·
Aug 28, 2024 1

MISSRec: Pre-training and Transferring Multi-modal Interest-aware Sequence Representation for Recommendation

The goal of sequential recommendation (SR) is to predict a user's potential interested items based on her/his historical interaction sequences. Most existing sequential recommenders are developed based on ID features, which, despite their widespread use, often underperform with sparse IDs and struggle with the cold-start problem. Besides, inconsistent ID mappings hinder the model's transferability, isolating similar recommendation domains that could have been co-optimized. This paper aims to address these issues by exploring the potential of multi-modal information in learning robust and generalizable sequence representations. We propose MISSRec, a multi-modal pre-training and transfer learning framework for SR. On the user side, we design a Transformer-based encoder-decoder model, where the contextual encoder learns to capture the sequence-level multi-modal user interests while a novel interest-aware decoder is developed to grasp item-modality-interest relations for better sequence representation. On the candidate item side, we adopt a dynamic fusion module to produce user-adaptive item representation, providing more precise matching between users and items. We pre-train the model with contrastive learning objectives and fine-tune it in an efficient manner. Extensive experiments demonstrate the effectiveness and flexibility of MISSRec, promising a practical solution for real-world recommendation scenarios. Data and code are available on https://github.com/gimpong/MM23-MISSRec.

  • 10 authors
·
Oct 22, 2023

Beyond Simple Concatenation: Fairly Assessing PLM Architectures for Multi-Chain Protein-Protein Interactions Prediction

Protein-protein interactions (PPIs) are fundamental to numerous cellular processes, and their characterization is vital for understanding disease mechanisms and guiding drug discovery. While protein language models (PLMs) have demonstrated remarkable success in predicting protein structure and function, their application to sequence-based PPI binding affinity prediction remains relatively underexplored. This gap is often attributed to the scarcity of high-quality, rigorously refined datasets and the reliance on simple strategies for concatenating protein representations. In this work, we address these limitations. First, we introduce a meticulously curated version of the PPB-Affinity dataset of a total of 8,207 unique protein-protein interaction entries, by resolving annotation inconsistencies and duplicate entries for multi-chain protein interactions. This dataset incorporates a stringent, less than or equal to 30%, sequence identity threshold to ensure robust splitting into training, validation, and test sets, minimizing data leakage. Second, we propose and systematically evaluate four architectures for adapting PLMs to PPI binding affinity prediction: embeddings concatenation (EC), sequences concatenation (SC), hierarchical pooling (HP), and pooled attention addition (PAD). These architectures were assessed using two training methods: full fine-tuning and a lightweight approach employing ConvBERT heads over frozen PLM features. Our comprehensive experiments across multiple leading PLMs (ProtT5, ESM2, Ankh, Ankh2, and ESM3) demonstrated that the HP and PAD architectures consistently outperform conventional concatenation methods, achieving up to 12% increase in terms of Spearman correlation. These results highlight the necessity of sophisticated architectural designs to fully exploit the capabilities of PLMs for nuanced PPI binding affinity prediction.

  • 8 authors
·
May 26, 2025 2

Multi-IF: Benchmarking LLMs on Multi-Turn and Multilingual Instructions Following

Large Language Models (LLMs) have demonstrated impressive capabilities in various tasks, including instruction following, which is crucial for aligning model outputs with user expectations. However, evaluating LLMs' ability to follow instructions remains challenging due to the complexity and subjectivity of human language. Current benchmarks primarily focus on single-turn, monolingual instructions, which do not adequately reflect the complexities of real-world applications that require handling multi-turn and multilingual interactions. To address this gap, we introduce Multi-IF, a new benchmark designed to assess LLMs' proficiency in following multi-turn and multilingual instructions. Multi-IF, which utilizes a hybrid framework combining LLM and human annotators, expands upon the IFEval by incorporating multi-turn sequences and translating the English prompts into another 7 languages, resulting in a dataset of 4,501 multilingual conversations, where each has three turns. Our evaluation of 14 state-of-the-art LLMs on Multi-IF reveals that it presents a significantly more challenging task than existing benchmarks. All the models tested showed a higher rate of failure in executing instructions correctly with each additional turn. For example, o1-preview drops from 0.877 at the first turn to 0.707 at the third turn in terms of average accuracy over all languages. Moreover, languages with non-Latin scripts (Hindi, Russian, and Chinese) generally exhibit higher error rates, suggesting potential limitations in the models' multilingual capabilities. We release Multi-IF prompts and the evaluation code base to encourage further research in this critical area.

  • 19 authors
·
Oct 20, 2024

UniGenX: Unified Generation of Sequence and Structure with Autoregressive Diffusion

Unified generation of sequence and structure for scientific data (e.g., materials, molecules, proteins) is a critical task. Existing approaches primarily rely on either autoregressive sequence models or diffusion models, each offering distinct advantages and facing notable limitations. Autoregressive models, such as GPT, Llama, and Phi-4, have demonstrated remarkable success in natural language generation and have been extended to multimodal tasks (e.g., image, video, and audio) using advanced encoders like VQ-VAE to represent complex modalities as discrete sequences. However, their direct application to scientific domains is challenging due to the high precision requirements and the diverse nature of scientific data. On the other hand, diffusion models excel at generating high-dimensional scientific data, such as protein, molecule, and material structures, with remarkable accuracy. Yet, their inability to effectively model sequences limits their potential as general-purpose multimodal foundation models. To address these challenges, we propose UniGenX, a unified framework that combines autoregressive next-token prediction with conditional diffusion models. This integration leverages the strengths of autoregressive models to ease the training of conditional diffusion models, while diffusion-based generative heads enhance the precision of autoregressive predictions. We validate the effectiveness of UniGenX on material and small molecule generation tasks, achieving a significant leap in state-of-the-art performance for material crystal structure prediction and establishing new state-of-the-art results for small molecule structure prediction, de novo design, and conditional generation. Notably, UniGenX demonstrates significant improvements, especially in handling long sequences for complex structures, showcasing its efficacy as a versatile tool for scientific data generation.

  • 25 authors
·
Mar 9, 2025

ReCUT: Balancing Reasoning Length and Accuracy in LLMs via Stepwise Trails and Preference Optimization

Recent advances in Chain-of-Thought (CoT) prompting have substantially improved the reasoning capabilities of Large Language Models (LLMs). However, these methods often suffer from overthinking, leading to unnecessarily lengthy or redundant reasoning traces. Existing approaches attempt to mitigate this issue through curating multiple reasoning chains for training LLMs, but their effectiveness is often constrained by the quality of the generated data and prone to overfitting. To address the challenge, we propose Reasoning Compression ThroUgh Stepwise Trials (ReCUT), a novel method aimed at balancing the accuracy and length of reasoning trajectory. Specifically, ReCUT employs a stepwise exploration mechanism and a long-short switched sampling strategy, enabling LLMs to incrementally generate diverse reasoning paths. These paths are evaluated and used to construct preference pairs to train two specialized models (Gemini LLMs)-one optimized for reasoning accuracy, the other for shorter reasoning. A final integrated model is obtained by interpolating the parameters of these two models. Experimental results across multiple math reasoning datasets and backbone models demonstrate that ReCUT significantly reduces reasoning lengths by approximately 30-50%, while maintaining or improving reasoning accuracy compared to various baselines. All codes and data will be released via https://github.com/NEUIR/ReCUT.

  • 10 authors
·
Jun 12, 2025

Topological Neural Dynamics: A Neuron-wise Framework for Sequence Modeling

Existing sequence models, including RNNs, LSTMs, continuous-time networks, and Transformers, share a common structural principle: layer-wise dynamics, where all neurons in the same layer co-evolve through a shared parameterized operator, leaving individual neurons no freedom to evolve independently. Yet in many complex dynamical systems, rich global behavior emerges precisely from locally evolving units interacting through structured connectivity. Inspired by this principle, we introduce Topological Neural Dynamics (TND), a sequence modeling framework that shifts computation from layer-wise to neuron-wise dynamics. TND represents a neural system as a directed neuron graph, an interaction operator, and a local dynamics function, where each neuron evolves independently and collective computation emerges from interactions through the explicit graph topology. We instantiate TND as a discrete-time graph-coupled dynamical system and evaluate it as a case study on a behavior cloning task in single-player Pong. Compared with Vanilla RNN, Sparse RNN, LSTM, Closed-form continuous-time neural network (CfC), and Transformer baselines, TND achieves the best catch rate and a mean of 17.47 consecutive catches per round, more than three times that of the strongest baseline. These results suggest that shifting from layer-wise to neuron-wise dynamics provides an effective inductive bias for sequence modeling.

  • 2 authors
·
Jun 30

SeeUPO: Sequence-Level Agentic-RL with Convergence Guarantees

Reinforcement learning (RL) has emerged as the predominant paradigm for training large language model (LLM)-based AI agents. However, existing backbone RL algorithms lack verified convergence guarantees in agentic scenarios, especially in multi-turn settings, which can lead to training instability and failure to converge to optimal policies. In this paper, we systematically analyze how different combinations of policy update mechanisms and advantage estimation methods affect convergence properties in single/multi-turn scenarios. We find that REINFORCE with Group Relative Advantage Estimation (GRAE) can converge to the globally optimal under undiscounted conditions, but the combination of PPO & GRAE breaks PPO's original monotonic improvement property. Furthermore, we demonstrate that mainstream backbone RL algorithms cannot simultaneously achieve both critic-free and convergence guarantees in multi-turn scenarios. To address this, we propose SeeUPO (Sequence-level Sequential Update Policy Optimization), a critic-free approach with convergence guarantees for multi-turn interactions. SeeUPO models multi-turn interaction as sequentially executed multi-agent bandit problems. Through turn-by-turn sequential policy updates in reverse execution order, it ensures monotonic improvement and convergence to global optimal solution via backward induction. Experiments on AppWorld and BFCL v4 demonstrate SeeUPO's substantial improvements over existing backbone algorithms: relative gains of 43.3%-54.6% on Qwen3-14B and 24.1%-41.9% on Qwen2.5-14B (averaged across benchmarks), along with superior training stability.

Tongyi-MAI Tongyi-MAI
·
Feb 6 2

Test-time regression: a unifying framework for designing sequence models with associative memory

Sequence models lie at the heart of modern deep learning. However, rapid advancements have produced a diversity of seemingly unrelated architectures, such as Transformers and recurrent alternatives. In this paper, we introduce a unifying framework to understand and derive these sequence models, inspired by the empirical importance of associative recall, the capability to retrieve contextually relevant tokens. We formalize associative recall as a two-step process, memorization and retrieval, casting memorization as a regression problem. Layers that combine these two steps perform associative recall via ``test-time regression'' over its input tokens. Prominent layers, including linear attention, state-space models, fast-weight programmers, online learners, and softmax attention, arise as special cases defined by three design choices: the regression weights, the regressor function class, and the test-time optimization algorithm. Our approach clarifies how linear attention fails to capture inter-token correlations and offers a mathematical justification for the empirical effectiveness of query-key normalization in softmax attention. Further, it illuminates unexplored regions within the design space, which we use to derive novel higher-order generalizations of softmax attention. Beyond unification, our work bridges sequence modeling with classic regression methods, a field with extensive literature, paving the way for developing more powerful and theoretically principled architectures.

  • 3 authors
·
Jan 21, 2025

Faster Re-translation Using Non-Autoregressive Model For Simultaneous Neural Machine Translation

Recently, simultaneous translation has gathered a lot of attention since it enables compelling applications such as subtitle translation for a live event or real-time video-call translation. Some of these translation applications allow editing of partial translation giving rise to re-translation approaches. The current re-translation approaches are based on autoregressive sequence generation models (ReTA), which generate tar-get tokens in the (partial) translation sequentially. The multiple re-translations with sequential generation inReTAmodelslead to an increased inference time gap between the incoming source input and the corresponding target output as the source input grows. Besides, due to the large number of inference operations involved, the ReTA models are not favorable for resource-constrained devices. In this work, we propose a faster re-translation system based on a non-autoregressive sequence generation model (FReTNA) to overcome the aforementioned limitations. We evaluate the proposed model on multiple translation tasks and our model reduces the inference times by several orders and achieves a competitive BLEUscore compared to the ReTA and streaming (Wait-k) models.The proposed model reduces the average computation time by a factor of 20 when compared to the ReTA model by incurring a small drop in the translation quality. It also outperforms the streaming-based Wait-k model both in terms of computation time (1.5 times lower) and translation quality.

  • 8 authors
·
Dec 29, 2020

MTVG : Multi-text Video Generation with Text-to-Video Models

Recently, video generation has attracted massive attention and yielded noticeable outcomes. Concerning the characteristics of video, multi-text conditioning incorporating sequential events is necessary for next-step video generation. In this work, we propose a novel multi-text video generation~(MTVG) by directly utilizing a pre-trained diffusion-based text-to-video~(T2V) generation model without additional fine-tuning. To generate consecutive video segments, visual consistency generated by distinct prompts is necessary with diverse variations, such as motion and content-related transitions. Our proposed MTVG includes Dynamic Noise and Last Frame Aware Inversion which reinitialize the noise latent to preserve visual coherence between videos of different prompts and prevent repetitive motion or contents. Furthermore, we present Structure Guiding Sampling to maintain the global appearance across the frames in a single video clip, where we leverage iterative latent updates across the preceding frame. Additionally, our Prompt Generator allows for arbitrary format of text conditions consisting of diverse events. As a result, our extensive experiments, including diverse transitions of descriptions, demonstrate that our proposed methods show superior generated outputs in terms of semantically coherent and temporally seamless video.Video examples are available in our project page: https://kuai-lab.github.io/mtvg-page.

  • 8 authors
·
Dec 7, 2023

Done Is Better than Perfect: Unlocking Efficient Reasoning by Structured Multi-Turn Decomposition

Large Reasoning Models (LRMs) are criticized for the excessively lengthy Chain-of-Thought (CoT) to derive the final answer, suffering from high first-token and overall latency. Typically, the CoT of LRMs mixes multiple thinking units; each unit attempts to produce a candidate answer to the original query. Hence, a natural idea to improve efficiency is to reduce the unit number. Yet, the fact that the thinking units in vanilla CoT cannot be explicitly managed renders doing so challenging. This paper introduces Multi-Turn Decomposition (MinD) to decode conventional CoT into a sequence of explicit, structured, and turn-wise interactions to bridge the gap. In MinD, the model provides a multi-turn response to the query, where each turn embraces a thinking unit and yields a corresponding answer. The subsequent turns can reflect, verify, revise, or explore alternative approaches to both the thinking and answer parts of earlier ones. This not only makes the answer delivered more swiftly, but also enables explicit controls over the iterative reasoning process (i.e., users may halt or continue at any turn). We follow a supervised fine-tuning (SFT) then reinforcement learning (RL) paradigm to realize MinD. We first rephrase the outputs of an LRM into multi-turn formats by prompting another LLM, and then tune the LRM with such data. Observing that the tuned model tends to consume even more tokens than the original one (probably due to that the multi-turn formats introduce additional answer tokens), we advocate leveraging RL algorithms like GRPO to prioritize correct outputs with fewer turns. Trained on the MATH dataset using R1-Distill models, MinD can achieve up to ~70% reduction in both output token usage and time to first token (TTFT), while maintaining competitive performance on reasoning benchmarks such as MATH-500, AIME24, AMC23, and GPQA-Diamond.

  • 5 authors
·
May 26, 2025 2

UltraTex: Unleashing 2K Multi-View Diffusion for 3D Texturing

High-quality texture generation is essential for creating realistic and production-ready 3D assets. Recent multi-view diffusion methods have shown promising results for image-guided 3D texturing, but they are typically constrained to low operating resolutions such as 512 or 768, making it difficult to preserve high-frequency details from high-resolution reference images. Scaling this paradigm to 2048 resolution is computationally prohibitive, as the unified multi-view sequence exceeds 212K tokens and incurs excessive memory and latency. In this paper, we present UltraTex, an efficient end-to-end framework for high-resolution multi-view diffusion-based 3D texturing. Our key observation is that object-centric multi-view renderings contain two major sources of redundancy: background-induced sequence redundancy and sparse token interactions within the foreground. To address them, we introduce Background Token Dropping, which removes background tokens before the DiT backbone, and Block-Sparse Attention, which reduces attention computation over the retained foreground sequence. To enable efficient foreground-only inference while avoiding reconstruction artifacts, we further design Foreground-Aware VAE Decoding to ensure the quality of the final high-resolution views. To satisfy the demanding data requirements of 2K-resolution multi-view diffusion training, we construct G-buffer TexVerse, a large-scale, ultra-high-resolution multi-view rendering dataset covering over 268,000 3D assets. Extensive experiments show that UltraTex generates visually faithful textures with rich fine-grained details, while substantially improving efficiency, achieving 20.6times--91.1times training speedup and 22.3times--74.6times end-to-end inference speedup over the baseline on common samples in our dataset. Code and data is at https://yiboz2001.github.io/UltraTex.

  • 7 authors
·
Sep 18 2

SineNet: Learning Temporal Dynamics in Time-Dependent Partial Differential Equations

We consider using deep neural networks to solve time-dependent partial differential equations (PDEs), where multi-scale processing is crucial for modeling complex, time-evolving dynamics. While the U-Net architecture with skip connections is commonly used by prior studies to enable multi-scale processing, our analysis shows that the need for features to evolve across layers results in temporally misaligned features in skip connections, which limits the model's performance. To address this limitation, we propose SineNet, consisting of multiple sequentially connected U-shaped network blocks, referred to as waves. In SineNet, high-resolution features are evolved progressively through multiple stages, thereby reducing the amount of misalignment within each stage. We furthermore analyze the role of skip connections in enabling both parallel and sequential processing of multi-scale information. Our method is rigorously tested on multiple PDE datasets, including the Navier-Stokes equations and shallow water equations, showcasing the advantages of our proposed approach over conventional U-Nets with a comparable parameter budget. We further demonstrate that increasing the number of waves in SineNet while maintaining the same number of parameters leads to a monotonically improved performance. The results highlight the effectiveness of SineNet and the potential of our approach in advancing the state-of-the-art in neural PDE solver design. Our code is available as part of AIRS (https://github.com/divelab/AIRS).

  • 7 authors
·
Mar 28, 2024

AFM-Net: Advanced Fusing Hierarchical CNN Visual Priors with Global Sequence Modeling for Remote Sensing Image Scene Classification

Remote sensing image scene classification remains a challenging task, primarily due to the complex spatial structures and multi-scale characteristics of ground objects. Existing approaches see CNNs excel at modeling local textures, while Transformers excel at capturing global context. However, efficiently integrating them remains a bottleneck due to the high computational cost of Transformers. To tackle this, we propose AFM-Net, a novel Advanced Hierarchical Fusing framework that achieves effective local and global co-representation through two pathways: a CNN branch for extracting hierarchical visual priors, and a Mamba branch for efficient global sequence modeling. The core innovation of AFM-Net lies in its Hierarchical Fusion Mechanism, which progressively aggregates multi-scale features from both pathways, enabling dynamic cross-level feature interaction and contextual reconstruction to produce highly discriminative representations. These fused features are then adaptively routed through a Mixture-of-Experts classifier module, which dispatches them to the most suitable experts for fine-grained scene recognition. Experiments on AID, NWPU-RESISC45, and UC Merced show that AFM-Net obtains 93.72, 95.54, and 96.92 percent accuracy, surpassing state-of-the-art methods with balanced performance and efficiency. Code is available at https://github.com/tangyuanhao-qhu/AFM-Net.

  • 6 authors
·
Oct 30, 2025

UniRef-Image-Edit: Towards Scalable and Consistent Multi-Reference Image Editing

We present UniRef-Image-Edit, a high-performance multi-modal generation system that unifies single-image editing and multi-image composition within a single framework. Existing diffusion-based editing methods often struggle to maintain consistency across multiple conditions due to limited interaction between reference inputs. To address this, we introduce Sequence-Extended Latent Fusion (SELF), a unified input representation that dynamically serializes multiple reference images into a coherent latent sequence. During a dedicated training stage, all reference images are jointly constrained to fit within a fixed-length sequence under a global pixel-budget constraint. Building upon SELF, we propose a two-stage training framework comprising supervised fine-tuning (SFT) and reinforcement learning (RL). In the SFT stage, we jointly train on single-image editing and multi-image composition tasks to establish a robust generative prior. We adopt a progressive sequence length training strategy, in which all input images are initially resized to a total pixel budget of 1024^2, and are then gradually increased to 1536^2 and 2048^2 to improve visual fidelity and cross-reference consistency. This gradual relaxation of compression enables the model to incrementally capture finer visual details while maintaining stable alignment across references. For the RL stage, we introduce Multi-Source GRPO (MSGRPO), to our knowledge the first reinforcement learning framework tailored for multi-reference image generation. MSGRPO optimizes the model to reconcile conflicting visual constraints, significantly enhancing compositional consistency. We will open-source the code, models, training data, and reward data for community research purposes.

  • 25 authors
·
Feb 14