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Feb 18

Program Merge Conflict Resolution via Neural Transformers

Collaborative software development is an integral part of the modern software development life cycle, essential to the success of large-scale software projects. When multiple developers make concurrent changes around the same lines of code, a merge conflict may occur. Such conflicts stall pull requests and continuous integration pipelines for hours to several days, seriously hurting developer productivity. To address this problem, we introduce MergeBERT, a novel neural program merge framework based on token-level three-way differencing and a transformer encoder model. By exploiting the restricted nature of merge conflict resolutions, we reformulate the task of generating the resolution sequence as a classification task over a set of primitive merge patterns extracted from real-world merge commit data. Our model achieves 63-68% accuracy for merge resolution synthesis, yielding nearly a 3x performance improvement over existing semi-structured, and 2x improvement over neural program merge tools. Finally, we demonstrate that MergeBERT is sufficiently flexible to work with source code files in Java, JavaScript, TypeScript, and C# programming languages. To measure the practical use of MergeBERT, we conduct a user study to evaluate MergeBERT suggestions with 25 developers from large OSS projects on 122 real-world conflicts they encountered. Results suggest that in practice, MergeBERT resolutions would be accepted at a higher rate than estimated by automatic metrics for precision and accuracy. Additionally, we use participant feedback to identify future avenues for improvement of MergeBERT.

  • 9 authors
·
Aug 31, 2021

Learning Trajectory-Aware Transformer for Video Super-Resolution

Video super-resolution (VSR) aims to restore a sequence of high-resolution (HR) frames from their low-resolution (LR) counterparts. Although some progress has been made, there are grand challenges to effectively utilize temporal dependency in entire video sequences. Existing approaches usually align and aggregate video frames from limited adjacent frames (e.g., 5 or 7 frames), which prevents these approaches from satisfactory results. In this paper, we take one step further to enable effective spatio-temporal learning in videos. We propose a novel Trajectory-aware Transformer for Video Super-Resolution (TTVSR). In particular, we formulate video frames into several pre-aligned trajectories which consist of continuous visual tokens. For a query token, self-attention is only learned on relevant visual tokens along spatio-temporal trajectories. Compared with vanilla vision Transformers, such a design significantly reduces the computational cost and enables Transformers to model long-range features. We further propose a cross-scale feature tokenization module to overcome scale-changing problems that often occur in long-range videos. Experimental results demonstrate the superiority of the proposed TTVSR over state-of-the-art models, by extensive quantitative and qualitative evaluations in four widely-used video super-resolution benchmarks. Both code and pre-trained models can be downloaded at https://github.com/researchmm/TTVSR.

  • 4 authors
·
Apr 7, 2022

HyenaDNA: Long-Range Genomic Sequence Modeling at Single Nucleotide Resolution

Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA. In addition, these methods rely on tokenizers to aggregate meaningful DNA units, losing single nucleotide resolution where subtle genetic variations can completely alter protein function via single nucleotide polymorphisms (SNPs). Recently, Hyena, a large language model based on implicit convolutions was shown to match attention in quality while allowing longer context lengths and lower time complexity. Leveraging Hyenas new long-range capabilities, we present HyenaDNA, a genomic foundation model pretrained on the human reference genome with context lengths of up to 1 million tokens at the single nucleotide-level, an up to 500x increase over previous dense attention-based models. HyenaDNA scales sub-quadratically in sequence length (training up to 160x faster than Transformer), uses single nucleotide tokens, and has full global context at each layer. We explore what longer context enables - including the first use of in-context learning in genomics for simple adaptation to novel tasks without updating pretrained model weights. On fine-tuned benchmarks from the Nucleotide Transformer, HyenaDNA reaches state-of-the-art (SotA) on 12 of 17 datasets using a model with orders of magnitude less parameters and pretraining data. On the GenomicBenchmarks, HyenaDNA surpasses SotA on all 8 datasets on average by +9 accuracy points.

  • 13 authors
·
Jun 27, 2023 2

ViG: Linear-complexity Visual Sequence Learning with Gated Linear Attention

Recently, linear complexity sequence modeling networks have achieved modeling capabilities similar to Vision Transformers on a variety of computer vision tasks, while using fewer FLOPs and less memory. However, their advantage in terms of actual runtime speed is not significant. To address this issue, we introduce Gated Linear Attention (GLA) for vision, leveraging its superior hardware-awareness and efficiency. We propose direction-wise gating to capture 1D global context through bidirectional modeling and a 2D gating locality injection to adaptively inject 2D local details into 1D global context. Our hardware-aware implementation further merges forward and backward scanning into a single kernel, enhancing parallelism and reducing memory cost and latency. The proposed model, ViG, offers a favorable trade-off in accuracy, parameters, and FLOPs on ImageNet and downstream tasks, outperforming popular Transformer and CNN-based models. Notably, ViG-S matches DeiT-B's accuracy while using only 27% of the parameters and 20% of the FLOPs, running 2times faster on 224times224 images. At 1024times1024 resolution, ViG-T uses 5.2times fewer FLOPs, saves 90% GPU memory, runs 4.8times faster, and achieves 20.7% higher top-1 accuracy than DeiT-T. These results position ViG as an efficient and scalable solution for visual representation learning. Code is available at https://github.com/hustvl/ViG.

  • 5 authors
·
May 28, 2024

DTVNet+: A High-Resolution Scenic Dataset for Dynamic Time-lapse Video Generation

This paper presents a novel end-to-end dynamic time-lapse video generation framework, named DTVNet, to generate diversified time-lapse videos from a single landscape image conditioned on normalized motion vectors. The proposed DTVNet consists of two submodules: Optical Flow Encoder (OFE) and Dynamic Video Generator (DVG). The OFE maps a sequence of optical flow maps to a normalized motion vector that encodes the motion information of the generated video. The DVG contains motion and content streams to learn from the motion vector and the single landscape image. Besides, it contains an encoder to learn shared content features and a decoder to construct video frames with corresponding motion. Specifically, the motion stream introduces multiple adaptive instance normalization (AdaIN) layers to integrate multi-level motion information for controlling the object motion. In the testing stage, videos with the same content but various motion information can be generated by different normalized motion vectors based on only one input image. Also, we propose a high-resolution scenic time-lapse video dataset, named Quick-Sky-Time, to evaluate different approaches, which can be viewed as a new benchmark for high-quality scenic image and video generation tasks. We further conduct experiments on Sky Time-lapse, Beach, and Quick-Sky-Time datasets. The results demonstrate the superiority of our approach over state-of-the-art methods for generating high-quality and various dynamic videos.

  • 4 authors
·
Aug 11, 2020

Syzygy of Thoughts: Improving LLM CoT with the Minimal Free Resolution

Chain-of-Thought (CoT) prompting enhances the reasoning of large language models (LLMs) by decomposing problems into sequential steps, mimicking human logic and reducing errors. However, complex tasks with vast solution spaces and vague constraints often exceed the capacity of a single reasoning chain. Inspired by Minimal Free Resolution (MFR) in commutative algebra and algebraic geometry, we propose Syzygy of Thoughts (SoT)-a novel framework that extends CoT by introducing auxiliary, interrelated reasoning paths. SoT captures deeper logical dependencies, enabling more robust and structured problem-solving. MFR decomposes a module into a sequence of free modules with minimal rank, providing a structured analytical approach to complex systems. This method introduces the concepts of "Module", "Betti numbers","Freeness", "Mapping", "Exactness" and "Minimality", enabling the systematic decomposition of the original complex problem into logically complete minimal subproblems while preserving key problem features and reducing reasoning length. We tested SoT across diverse datasets (e.g., GSM8K, MATH) and models (e.g., GPT-4o-mini, Qwen2.5), achieving inference accuracy that matches or surpasses mainstream CoTs standards. Additionally, by aligning the sampling process with algebraic constraints, our approach enhances the scalability of inference time in LLMs, ensuring both transparent reasoning and high performance. Our code will be publicly available at https://github.com/dlMARiA/Syzygy-of-thoughts.

  • 10 authors
·
Apr 13, 2025 2

Skywork UniPic 3.0: Unified Multi-Image Composition via Sequence Modeling

The recent surge in popularity of Nano-Banana and Seedream 4.0 underscores the community's strong interest in multi-image composition tasks. Compared to single-image editing, multi-image composition presents significantly greater challenges in terms of consistency and quality, yet existing models have not disclosed specific methodological details for achieving high-quality fusion. Through statistical analysis, we identify Human-Object Interaction (HOI) as the most sought-after category by the community. We therefore systematically analyze and implement a state-of-the-art solution for multi-image composition with a primary focus on HOI-centric tasks. We present Skywork UniPic 3.0, a unified multimodal framework that integrates single-image editing and multi-image composition. Our model supports an arbitrary (1~6) number and resolution of input images, as well as arbitrary output resolutions (within a total pixel budget of 1024x1024). To address the challenges of multi-image composition, we design a comprehensive data collection, filtering, and synthesis pipeline, achieving strong performance with only 700K high-quality training samples. Furthermore, we introduce a novel training paradigm that formulates multi-image composition as a sequence-modeling problem, transforming conditional generation into unified sequence synthesis. To accelerate inference, we integrate trajectory mapping and distribution matching into the post-training stage, enabling the model to produce high-fidelity samples in just 8 steps and achieve a 12.5x speedup over standard synthesis sampling. Skywork UniPic 3.0 achieves state-of-the-art performance on single-image editing benchmark and surpasses both Nano-Banana and Seedream 4.0 on multi-image composition benchmark, thereby validating the effectiveness of our data pipeline and training paradigm. Code, models and dataset are publicly available.

  • 14 authors
·
Jan 22

Scale-DiT: Ultra-High-Resolution Image Generation with Hierarchical Local Attention

Ultra-high-resolution text-to-image generation demands both fine-grained texture synthesis and globally coherent structure, yet current diffusion models remain constrained to sub-1K times 1K resolutions due to the prohibitive quadratic complexity of attention and the scarcity of native 4K training data. We present Scale-DiT, a new diffusion framework that introduces hierarchical local attention with low-resolution global guidance, enabling efficient, scalable, and semantically coherent image synthesis at ultra-high resolutions. Specifically, high-resolution latents are divided into fixed-size local windows to reduce attention complexity from quadratic to near-linear, while a low-resolution latent equipped with scaled positional anchors injects global semantics. A lightweight LoRA adaptation bridges global and local pathways during denoising, ensuring consistency across structure and detail. To maximize inference efficiency, we repermute token sequence in Hilbert curve order and implement a fused-kernel for skipping masked operations, resulting in a GPU-friendly design. Extensive experiments demonstrate that Scale-DiT achieves more than 2times faster inference and lower memory usage compared to dense attention baselines, while reliably scaling to 4K times 4K resolution without requiring additional high-resolution training data. On both quantitative benchmarks (FID, IS, CLIP Score) and qualitative comparisons, Scale-DiT delivers superior global coherence and sharper local detail, matching or outperforming state-of-the-art methods that rely on native 4K training. Taken together, these results highlight hierarchical local attention with guided low-resolution anchors as a promising and effective approach for advancing ultra-high-resolution image generation.

  • 2 authors
·
Oct 17, 2025

Multi-resolution Networks For Flexible Irregular Time Series Modeling (Multi-FIT)

Missing values, irregularly collected samples, and multi-resolution signals commonly occur in multivariate time series data, making predictive tasks difficult. These challenges are especially prevalent in the healthcare domain, where patients' vital signs and electronic records are collected at different frequencies and have occasionally missing information due to the imperfections in equipment or patient circumstances. Researchers have handled each of these issues differently, often handling missing data through mean value imputation and then using sequence models over the multivariate signals while ignoring the different resolution of signals. We propose a unified model named Multi-resolution Flexible Irregular Time series Network (Multi-FIT). The building block for Multi-FIT is the FIT network. The FIT network creates an informative dense representation at each time step using signal information such as last observed value, time difference since the last observed time stamp and overall mean for the signal. Vertical FIT (FIT-V) is a variant of FIT which also models the relationship between different temporal signals while creating the informative dense representations for the signal. The multi-FIT model uses multiple FIT networks for sets of signals with different resolutions, further facilitating the construction of flexible representations. Our model has three main contributions: a.) it does not impute values but rather creates informative representations to provide flexibility to the model for creating task-specific representations b.) it models the relationship between different signals in the form of support signals c.) it models different resolutions in parallel before merging them for the final prediction task. The FIT, FIT-V and Multi-FIT networks improve upon the state-of-the-art models for three predictive tasks, including the forecasting of patient survival.

  • 7 authors
·
Apr 30, 2019

High-Dynamic Radar Sequence Prediction for Weather Nowcasting Using Spatiotemporal Coherent Gaussian Representation

Weather nowcasting is an essential task that involves predicting future radar echo sequences based on current observations, offering significant benefits for disaster management, transportation, and urban planning. Current prediction methods are limited by training and storage efficiency, mainly focusing on 2D spatial predictions at specific altitudes. Meanwhile, 3D volumetric predictions at each timestamp remain largely unexplored. To address such a challenge, we introduce a comprehensive framework for 3D radar sequence prediction in weather nowcasting, using the newly proposed SpatioTemporal Coherent Gaussian Splatting (STC-GS) for dynamic radar representation and GauMamba for efficient and accurate forecasting. Specifically, rather than relying on a 4D Gaussian for dynamic scene reconstruction, STC-GS optimizes 3D scenes at each frame by employing a group of Gaussians while effectively capturing their movements across consecutive frames. It ensures consistent tracking of each Gaussian over time, making it particularly effective for prediction tasks. With the temporally correlated Gaussian groups established, we utilize them to train GauMamba, which integrates a memory mechanism into the Mamba framework. This allows the model to learn the temporal evolution of Gaussian groups while efficiently handling a large volume of Gaussian tokens. As a result, it achieves both efficiency and accuracy in forecasting a wide range of dynamic meteorological radar signals. The experimental results demonstrate that our STC-GS can efficiently represent 3D radar sequences with over 16times higher spatial resolution compared with the existing 3D representation methods, while GauMamba outperforms state-of-the-art methods in forecasting a broad spectrum of high-dynamic weather conditions.

  • 4 authors
·
Feb 17, 2025

Hierarchical Masked Autoregressive Models with Low-Resolution Token Pivots

Autoregressive models have emerged as a powerful generative paradigm for visual generation. The current de-facto standard of next token prediction commonly operates over a single-scale sequence of dense image tokens, and is incapable of utilizing global context especially for early tokens prediction. In this paper, we introduce a new autoregressive design to model a hierarchy from a few low-resolution image tokens to the typical dense image tokens, and delve into a thorough hierarchical dependency across multi-scale image tokens. Technically, we present a Hierarchical Masked Autoregressive models (Hi-MAR) that pivot on low-resolution image tokens to trigger hierarchical autoregressive modeling in a multi-phase manner. Hi-MAR learns to predict a few image tokens in low resolution, functioning as intermediary pivots to reflect global structure, in the first phase. Such pivots act as the additional guidance to strengthen the next autoregressive modeling phase by shaping global structural awareness of typical dense image tokens. A new Diffusion Transformer head is further devised to amplify the global context among all tokens for mask token prediction. Extensive evaluations on both class-conditional and text-to-image generation tasks demonstrate that Hi-MAR outperforms typical AR baselines, while requiring fewer computational costs. Code is available at https://github.com/HiDream-ai/himar.

  • 7 authors
·
May 26, 2025

Mamba-based Light Field Super-Resolution with Efficient Subspace Scanning

Transformer-based methods have demonstrated impressive performance in 4D light field (LF) super-resolution by effectively modeling long-range spatial-angular correlations, but their quadratic complexity hinders the efficient processing of high resolution 4D inputs, resulting in slow inference speed and high memory cost. As a compromise, most prior work adopts a patch-based strategy, which fails to leverage the full information from the entire input LFs. The recently proposed selective state-space model, Mamba, has gained popularity for its efficient long-range sequence modeling. In this paper, we propose a Mamba-based Light Field Super-Resolution method, named MLFSR, by designing an efficient subspace scanning strategy. Specifically, we tokenize 4D LFs into subspace sequences and conduct bi-directional scanning on each subspace. Based on our scanning strategy, we then design the Mamba-based Global Interaction (MGI) module to capture global information and the local Spatial- Angular Modulator (SAM) to complement local details. Additionally, we introduce a Transformer-to-Mamba (T2M) loss to further enhance overall performance. Extensive experiments on public benchmarks demonstrate that MLFSR surpasses CNN-based models and rivals Transformer-based methods in performance while maintaining higher efficiency. With quicker inference speed and reduced memory demand, MLFSR facilitates full-image processing of high-resolution 4D LFs with enhanced performance.

  • 3 authors
·
Jun 23, 2024

SeqTex: Generate Mesh Textures in Video Sequence

Training native 3D texture generative models remains a fundamental yet challenging problem, largely due to the limited availability of large-scale, high-quality 3D texture datasets. This scarcity hinders generalization to real-world scenarios. To address this, most existing methods finetune foundation image generative models to exploit their learned visual priors. However, these approaches typically generate only multi-view images and rely on post-processing to produce UV texture maps -- an essential representation in modern graphics pipelines. Such two-stage pipelines often suffer from error accumulation and spatial inconsistencies across the 3D surface. In this paper, we introduce SeqTex, a novel end-to-end framework that leverages the visual knowledge encoded in pretrained video foundation models to directly generate complete UV texture maps. Unlike previous methods that model the distribution of UV textures in isolation, SeqTex reformulates the task as a sequence generation problem, enabling the model to learn the joint distribution of multi-view renderings and UV textures. This design effectively transfers the consistent image-space priors from video foundation models into the UV domain. To further enhance performance, we propose several architectural innovations: a decoupled multi-view and UV branch design, geometry-informed attention to guide cross-domain feature alignment, and adaptive token resolution to preserve fine texture details while maintaining computational efficiency. Together, these components allow SeqTex to fully utilize pretrained video priors and synthesize high-fidelity UV texture maps without the need for post-processing. Extensive experiments show that SeqTex achieves state-of-the-art performance on both image-conditioned and text-conditioned 3D texture generation tasks, with superior 3D consistency, texture-geometry alignment, and real-world generalization.

  • 7 authors
·
Jul 6, 2025 1

Motion-Guided Latent Diffusion for Temporally Consistent Real-world Video Super-resolution

Real-world low-resolution (LR) videos have diverse and complex degradations, imposing great challenges on video super-resolution (VSR) algorithms to reproduce their high-resolution (HR) counterparts with high quality. Recently, the diffusion models have shown compelling performance in generating realistic details for image restoration tasks. However, the diffusion process has randomness, making it hard to control the contents of restored images. This issue becomes more serious when applying diffusion models to VSR tasks because temporal consistency is crucial to the perceptual quality of videos. In this paper, we propose an effective real-world VSR algorithm by leveraging the strength of pre-trained latent diffusion models. To ensure the content consistency among adjacent frames, we exploit the temporal dynamics in LR videos to guide the diffusion process by optimizing the latent sampling path with a motion-guided loss, ensuring that the generated HR video maintains a coherent and continuous visual flow. To further mitigate the discontinuity of generated details, we insert temporal module to the decoder and fine-tune it with an innovative sequence-oriented loss. The proposed motion-guided latent diffusion (MGLD) based VSR algorithm achieves significantly better perceptual quality than state-of-the-arts on real-world VSR benchmark datasets, validating the effectiveness of the proposed model design and training strategies.

  • 4 authors
·
Dec 1, 2023

DetailFlow: 1D Coarse-to-Fine Autoregressive Image Generation via Next-Detail Prediction

This paper presents DetailFlow, a coarse-to-fine 1D autoregressive (AR) image generation method that models images through a novel next-detail prediction strategy. By learning a resolution-aware token sequence supervised with progressively degraded images, DetailFlow enables the generation process to start from the global structure and incrementally refine details. This coarse-to-fine 1D token sequence aligns well with the autoregressive inference mechanism, providing a more natural and efficient way for the AR model to generate complex visual content. Our compact 1D AR model achieves high-quality image synthesis with significantly fewer tokens than previous approaches, i.e. VAR/VQGAN. We further propose a parallel inference mechanism with self-correction that accelerates generation speed by approximately 8x while reducing accumulation sampling error inherent in teacher-forcing supervision. On the ImageNet 256x256 benchmark, our method achieves 2.96 gFID with 128 tokens, outperforming VAR (3.3 FID) and FlexVAR (3.05 FID), which both require 680 tokens in their AR models. Moreover, due to the significantly reduced token count and parallel inference mechanism, our method runs nearly 2x faster inference speed compared to VAR and FlexVAR. Extensive experimental results demonstrate DetailFlow's superior generation quality and efficiency compared to existing state-of-the-art methods.

  • 13 authors
·
May 27, 2025 2

Open-Qwen2VL: Compute-Efficient Pre-Training of Fully-Open Multimodal LLMs on Academic Resources

The reproduction of state-of-the-art multimodal LLM pre-training faces barriers at every stage of the pipeline, including high-quality data filtering, multimodal data mixture strategies, sequence packing techniques, and training frameworks. We introduce Open-Qwen2VL, a fully open-source 2B-parameter Multimodal Large Language Model pre-trained efficiently on 29M image-text pairs using only 442 A100-40G GPU hours. Our approach employs low-to-high dynamic image resolution and multimodal sequence packing to significantly enhance pre-training efficiency. The training dataset was carefully curated using both MLLM-based filtering techniques (e.g., MLM-Filter) and conventional CLIP-based filtering methods, substantially improving data quality and training efficiency. The Open-Qwen2VL pre-training is conducted on academic level 8xA100-40G GPUs at UCSB on 5B packed multimodal tokens, which is 0.36\% of 1.4T multimodal pre-training tokens of Qwen2-VL. The final instruction-tuned Open-Qwen2VL outperforms partially-open state-of-the-art MLLM Qwen2-VL-2B on various multimodal benchmarks of MMBench, SEEDBench, MMstar, and MathVista, indicating the remarkable training efficiency of Open-Qwen2VL. We open-source all aspects of our work, including compute-efficient and data-efficient training details, data filtering methods, sequence packing scripts, pre-training data in WebDataset format, FSDP-based training codebase, and both base and instruction-tuned model checkpoints. We redefine "fully open" for multimodal LLMs as the complete release of: 1) the training codebase, 2) detailed data filtering techniques, and 3) all pre-training and supervised fine-tuning data used to develop the model.

  • 5 authors
·
Apr 1, 2025 7

InfiMed-Foundation: Pioneering Advanced Multimodal Medical Models with Compute-Efficient Pre-Training and Multi-Stage Fine-Tuning

Multimodal large language models (MLLMs) have shown remarkable potential in various domains, yet their application in the medical field is hindered by several challenges. General-purpose MLLMs often lack the specialized knowledge required for medical tasks, leading to uncertain or hallucinatory responses. Knowledge distillation from advanced models struggles to capture domain-specific expertise in radiology and pharmacology. Additionally, the computational cost of continual pretraining with large-scale medical data poses significant efficiency challenges. To address these issues, we propose InfiMed-Foundation-1.7B and InfiMed-Foundation-4B, two medical-specific MLLMs designed to deliver state-of-the-art performance in medical applications. We combined high-quality general-purpose and medical multimodal data and proposed a novel five-dimensional quality assessment framework to curate high-quality multimodal medical datasets. We employ low-to-high image resolution and multimodal sequence packing to enhance training efficiency, enabling the integration of extensive medical data. Furthermore, a three-stage supervised fine-tuning process ensures effective knowledge extraction for complex medical tasks. Evaluated on the MedEvalKit framework, InfiMed-Foundation-1.7B outperforms Qwen2.5VL-3B, while InfiMed-Foundation-4B surpasses HuatuoGPT-V-7B and MedGemma-27B-IT, demonstrating superior performance in medical visual question answering and diagnostic tasks. By addressing key challenges in data quality, training efficiency, and domain-specific knowledge extraction, our work paves the way for more reliable and effective AI-driven solutions in healthcare. InfiMed-Foundation-4B model is available at https://huggingface.co/InfiX-ai/InfiMed-Foundation-4B{InfiMed-Foundation-4B}.

  • 6 authors
·
Sep 26, 2025

FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioning

Scaling Transformers to longer sequence lengths has been a major problem in the last several years, promising to improve performance in language modeling and high-resolution image understanding, as well as to unlock new applications in code, audio, and video generation. The attention layer is the main bottleneck in scaling to longer sequences, as its runtime and memory increase quadratically in the sequence length. FlashAttention exploits the asymmetric GPU memory hierarchy to bring significant memory saving (linear instead of quadratic) and runtime speedup (2-4times compared to optimized baselines), with no approximation. However, FlashAttention is still not nearly as fast as optimized matrix-multiply (GEMM) operations, reaching only 25-40\% of the theoretical maximum FLOPs/s. We observe that the inefficiency is due to suboptimal work partitioning between different thread blocks and warps on the GPU, causing either low-occupancy or unnecessary shared memory reads/writes. We propose FlashAttention-2, with better work partitioning to address these issues. In particular, we (1) tweak the algorithm to reduce the number of non-matmul FLOPs (2) parallelize the attention computation, even for a single head, across different thread blocks to increase occupancy, and (3) within each thread block, distribute the work between warps to reduce communication through shared memory. These yield around 2times speedup compared to FlashAttention, reaching 50-73\% of the theoretical maximum FLOPs/s on A100 and getting close to the efficiency of GEMM operations. We empirically validate that when used end-to-end to train GPT-style models, FlashAttention-2 reaches training speed of up to 225 TFLOPs/s per A100 GPU (72\% model FLOPs utilization).

  • 1 authors
·
Jul 17, 2023

A Neural PDE Solver with Temporal Stencil Modeling

Numerical simulation of non-linear partial differential equations plays a crucial role in modeling physical science and engineering phenomena, such as weather, climate, and aerodynamics. Recent Machine Learning (ML) models trained on low-resolution spatio-temporal signals have shown new promises in capturing important dynamics in high-resolution signals, under the condition that the models can effectively recover the missing details. However, this study shows that significant information is often lost in the low-resolution down-sampled features. To address such issues, we propose a new approach, namely Temporal Stencil Modeling (TSM), which combines the strengths of advanced time-series sequence modeling (with the HiPPO features) and state-of-the-art neural PDE solvers (with learnable stencil modeling). TSM aims to recover the lost information from the PDE trajectories and can be regarded as a temporal generalization of classic finite volume methods such as WENO. Our experimental results show that TSM achieves the new state-of-the-art simulation accuracy for 2-D incompressible Navier-Stokes turbulent flows: it significantly outperforms the previously reported best results by 19.9% in terms of the highly-correlated duration time and reduces the inference latency into 80%. We also show a strong generalization ability of the proposed method to various out-of-distribution turbulent flow settings. Our code is available at "https://github.com/Edward-Sun/TSM-PDE".

  • 3 authors
·
Feb 16, 2023

ParaFold: Paralleling AlphaFold for Large-Scale Predictions

AlphaFold predicts protein structures from the amino acid sequence at or near experimental resolution, solving the 50-year-old protein folding challenge, leading to progress by transforming large-scale genomics data into protein structures. AlphaFold will also greatly change the scientific research model from low-throughput to high-throughput manner. The AlphaFold framework is a mixture of two types of workloads: MSA construction based on CPUs and model inference on GPUs. The first CPU stage dominates the overall runtime, taking hours for a single protein due to the large database sizes and I/O bottlenecks. However, GPUs in this CPU stage remain idle, resulting in low GPU utilization and restricting the capacity of large-scale structure predictions. Therefore, we proposed ParaFold, an open-source parallel version of AlphaFold for high throughput protein structure predictions. ParaFold separates the CPU and GPU parts to enable large-scale structure predictions. ParaFold also effectively reduces the CPU and GPU runtime with two optimizations without compromising the quality of prediction results: using multi-threaded parallelism on CPUs and using optimized JAX compilation on GPUs. We evaluated ParaFold with three datasets of different size and protein lengths. We evaluated the accuracy and efficiency of optimizations on CPUs and GPUs, and showed the large-scale prediction capability by running ParaFold inferences of 19,704 small proteins in five hours on one NVIDIA DGX-2. Using the JAX compile optimization, ParaFold attained a 13.8X average speedup over AlphaFold. ParaFold offers a rapid and effective approach for high-throughput structure predictions, leveraging the predictive power by running on supercomputers, with shorter time, and at a lower cost. The development of ParaFold will greatly speed up high-throughput studies and render the protein "structure-omics" feasible.

  • 6 authors
·
Nov 11, 2021

Instella-T2I: Pushing the Limits of 1D Discrete Latent Space Image Generation

Image tokenization plays a critical role in reducing the computational demands of modeling high-resolution images, significantly improving the efficiency of image and multimodal understanding and generation. Recent advances in 1D latent spaces have reduced the number of tokens required by eliminating the need for a 2D grid structure. In this paper, we further advance compact discrete image representation by introducing 1D binary image latents. By representing each image as a sequence of binary vectors, rather than using traditional one-hot codebook tokens, our approach preserves high-resolution details while maintaining the compactness of 1D latents. To the best of our knowledge, our text-to-image models are the first to achieve competitive performance in both diffusion and auto-regressive generation using just 128 discrete tokens for images up to 1024x1024, demonstrating up to a 32-fold reduction in token numbers compared to standard VQ-VAEs. The proposed 1D binary latent space, coupled with simple model architectures, achieves marked improvements in speed training and inference speed. Our text-to-image models allow for a global batch size of 4096 on a single GPU node with 8 AMD MI300X GPUs, and the training can be completed within 200 GPU days. Our models achieve competitive performance compared to modern image generation models without any in-house private training data or post-training refinements, offering a scalable and efficient alternative to conventional tokenization methods.

  • 10 authors
·
Jun 26, 2025

Better Tokens for Better 3D: Advancing Vision-Language Modeling in 3D Medical Imaging

Recent progress in vision-language modeling for 3D medical imaging has been fueled by large-scale computed tomography (CT) corpora with paired free-text reports, stronger architectures, and powerful pretrained models. This has enabled applications such as automated report generation and text-conditioned 3D image synthesis. Yet, current approaches struggle with high-resolution, long-sequence volumes: contrastive pretraining often yields vision encoders that are misaligned with clinical language, and slice-wise tokenization blurs fine anatomy, reducing diagnostic performance on downstream tasks. We introduce BTB3D (Better Tokens for Better 3D), a causal convolutional encoder-decoder that unifies 2D and 3D training and inference while producing compact, frequency-aware volumetric tokens. A three-stage training curriculum enables (i) local reconstruction, (ii) overlapping-window tiling, and (iii) long-context decoder refinement, during which the model learns from short slice excerpts yet generalizes to scans exceeding 300 slices without additional memory overhead. BTB3D sets a new state-of-the-art on two key tasks: it improves BLEU scores and increases clinical F1 by 40% over CT2Rep, CT-CHAT, and Merlin for report generation; and it reduces FID by 75% and halves FVD compared to GenerateCT and MedSyn for text-to-CT synthesis, producing anatomically consistent 512*512*241 volumes. These results confirm that precise three-dimensional tokenization, rather than larger language backbones alone, is essential for scalable vision-language modeling in 3D medical imaging. The codebase is available at: https://github.com/ibrahimethemhamamci/BTB3D

  • 10 authors
·
Oct 23, 2025

LEOPARD : A Vision Language Model For Text-Rich Multi-Image Tasks

Text-rich images, where text serves as the central visual element guiding the overall understanding, are prevalent in real-world applications, such as presentation slides, scanned documents, and webpage snapshots. Tasks involving multiple text-rich images are especially challenging, as they require not only understanding the content of individual images but reasoning about inter-relationships and logical flows across multiple visual inputs. Despite the importance of these scenarios, current multimodal large language models (MLLMs) struggle to handle such tasks due to two key challenges: (1) the scarcity of high-quality instruction tuning datasets for text-rich multi-image scenarios, and (2) the difficulty in balancing image resolution with visual feature sequence length. To address these challenges, we propose \OurMethod, a MLLM designed specifically for handling vision-language tasks involving multiple text-rich images. First, we curated about one million high-quality multimodal instruction-tuning data, tailored to text-rich, multi-image scenarios. Second, we developed an adaptive high-resolution multi-image encoding module to dynamically optimize the allocation of visual sequence length based on the original aspect ratios and resolutions of the input images. Experiments across a wide range of benchmarks demonstrate our model's superior capabilities in text-rich, multi-image evaluations and competitive performance in general domain evaluations.

Meshtron: High-Fidelity, Artist-Like 3D Mesh Generation at Scale

Meshes are fundamental representations of 3D surfaces. However, creating high-quality meshes is a labor-intensive task that requires significant time and expertise in 3D modeling. While a delicate object often requires over 10^4 faces to be accurately modeled, recent attempts at generating artist-like meshes are limited to 1.6K faces and heavy discretization of vertex coordinates. Hence, scaling both the maximum face count and vertex coordinate resolution is crucial to producing high-quality meshes of realistic, complex 3D objects. We present Meshtron, a novel autoregressive mesh generation model able to generate meshes with up to 64K faces at 1024-level coordinate resolution --over an order of magnitude higher face count and 8{times} higher coordinate resolution than current state-of-the-art methods. Meshtron's scalability is driven by four key components: (1) an hourglass neural architecture, (2) truncated sequence training, (3) sliding window inference, (4) a robust sampling strategy that enforces the order of mesh sequences. This results in over 50{%} less training memory, 2.5{times} faster throughput, and better consistency than existing works. Meshtron generates meshes of detailed, complex 3D objects at unprecedented levels of resolution and fidelity, closely resembling those created by professional artists, and opening the door to more realistic generation of detailed 3D assets for animation, gaming, and virtual environments.

  • 4 authors
·
Dec 12, 2024

ViR: Vision Retention Networks

Vision Transformers (ViTs) have attracted a lot of popularity in recent years, due to their exceptional capabilities in modeling long-range spatial dependencies and scalability for large scale training. Although the training parallelism of self-attention mechanism plays an important role in retaining great performance, its quadratic complexity baffles the application of ViTs in many scenarios which demand fast inference. This effect is even more pronounced in applications in which autoregressive modeling of input features is required. In Natural Language Processing (NLP), a new stream of efforts have proposed parallelizable models with recurrent formulation that allows for efficient inference in generative applications. Inspired by this trend, we propose a new class of computer vision models, dubbed Vision Retention Networks (ViR), with dual parallel and recurrent formulations, which strike an optimal balance between fast inference and parallel training with competitive performance. In particular, ViR scales favorably for image throughput and memory consumption in tasks that require higher-resolution images due to its flexible formulation in processing large sequence lengths. The ViR is the first attempt to realize dual parallel and recurrent equivalency in a general vision backbone for recognition tasks. We have validated the effectiveness of ViR through extensive experiments with different dataset sizes and various image resolutions and achieved competitive performance. Our code and pretrained models will be made publicly available.

  • 3 authors
·
Oct 30, 2023 1

Pep2Prob Benchmark: Predicting Fragment Ion Probability for MS$^2$-based Proteomics

Proteins perform nearly all cellular functions and constitute most drug targets, making their analysis fundamental to understanding human biology in health and disease. Tandem mass spectrometry (MS^2) is the major analytical technique in proteomics that identifies peptides by ionizing them, fragmenting them, and using the resulting mass spectra to identify and quantify proteins in biological samples. In MS^2 analysis, peptide fragment ion probability prediction plays a critical role, enhancing the accuracy of peptide identification from mass spectra as a complement to the intensity information. Current approaches rely on global statistics of fragmentation, which assumes that a fragment's probability is uniform across all peptides. Nevertheless, this assumption is oversimplified from a biochemical principle point of view and limits accurate prediction. To address this gap, we present Pep2Prob, the first comprehensive dataset and benchmark designed for peptide-specific fragment ion probability prediction. The proposed dataset contains fragment ion probability statistics for 608,780 unique precursors (each precursor is a pair of peptide sequence and charge state), summarized from more than 183 million high-quality, high-resolution, HCD MS^2 spectra with validated peptide assignments and fragmentation annotations. We establish baseline performance using simple statistical rules and learning-based methods, and find that models leveraging peptide-specific information significantly outperform previous methods using only global fragmentation statistics. Furthermore, performance across benchmark models with increasing capacities suggests that the peptide-fragmentation relationship exhibits complex nonlinearities requiring sophisticated machine learning approaches.

  • 5 authors
·
Aug 12, 2025

Multicell-Fold: geometric learning in folding multicellular life

During developmental processes such as embryogenesis, how a group of cells fold into specific structures, is a central question in biology that defines how living organisms form. Establishing tissue-level morphology critically relies on how every single cell decides to position itself relative to its neighboring cells. Despite its importance, it remains a major challenge to understand and predict the behavior of every cell within the living tissue over time during such intricate processes. To tackle this question, we propose a geometric deep learning model that can predict multicellular folding and embryogenesis, accurately capturing the highly convoluted spatial interactions among cells. We demonstrate that multicellular data can be represented with both granular and foam-like physical pictures through a unified graph data structure, considering both cellular interactions and cell junction networks. We successfully use our model to achieve two important tasks, interpretable 4-D morphological sequence alignment, and predicting local cell rearrangements before they occur at single-cell resolution. Furthermore, using an activation map and ablation studies, we demonstrate that cell geometries and cell junction networks together regulate local cell rearrangement which is critical for embryo morphogenesis. This approach provides a novel paradigm to study morphogenesis, highlighting a unified data structure and harnessing the power of geometric deep learning to accurately model the mechanisms and behaviors of cells during development. It offers a pathway toward creating a unified dynamic morphological atlas for a variety of developmental processes such as embryogenesis.

  • 5 authors
·
Jul 9, 2024

MIRIX: Multi-Agent Memory System for LLM-Based Agents

Although memory capabilities of AI agents are gaining increasing attention, existing solutions remain fundamentally limited. Most rely on flat, narrowly scoped memory components, constraining their ability to personalize, abstract, and reliably recall user-specific information over time. To this end, we introduce MIRIX, a modular, multi-agent memory system that redefines the future of AI memory by solving the field's most critical challenge: enabling language models to truly remember. Unlike prior approaches, MIRIX transcends text to embrace rich visual and multimodal experiences, making memory genuinely useful in real-world scenarios. MIRIX consists of six distinct, carefully structured memory types: Core, Episodic, Semantic, Procedural, Resource Memory, and Knowledge Vault, coupled with a multi-agent framework that dynamically controls and coordinates updates and retrieval. This design enables agents to persist, reason over, and accurately retrieve diverse, long-term user data at scale. We validate MIRIX in two demanding settings. First, on ScreenshotVQA, a challenging multimodal benchmark comprising nearly 20,000 high-resolution computer screenshots per sequence, requiring deep contextual understanding and where no existing memory systems can be applied, MIRIX achieves 35% higher accuracy than the RAG baseline while reducing storage requirements by 99.9%. Second, on LOCOMO, a long-form conversation benchmark with single-modal textual input, MIRIX attains state-of-the-art performance of 85.4%, far surpassing existing baselines. These results show that MIRIX sets a new performance standard for memory-augmented LLM agents. To allow users to experience our memory system, we provide a packaged application powered by MIRIX. It monitors the screen in real time, builds a personalized memory base, and offers intuitive visualization and secure local storage to ensure privacy.

  • 2 authors
·
Jul 10, 2025 1

FlashFFTConv: Efficient Convolutions for Long Sequences with Tensor Cores

Convolution models with long filters have demonstrated state-of-the-art reasoning abilities in many long-sequence tasks but lag behind the most optimized Transformers in wall-clock time. A major bottleneck is the Fast Fourier Transform (FFT)--which allows long convolutions to run in O(N logN) time in sequence length N but has poor hardware utilization. In this paper, we study how to optimize the FFT convolution. We find two key bottlenecks: the FFT does not effectively use specialized matrix multiply units, and it incurs expensive I/O between layers of the memory hierarchy. In response, we propose FlashFFTConv. FlashFFTConv uses a matrix decomposition that computes the FFT using matrix multiply units and enables kernel fusion for long sequences, reducing I/O. We also present two sparse convolution algorithms--1) partial convolutions and 2) frequency-sparse convolutions--which can be implemented simply by skipping blocks in the matrix decomposition, enabling further opportunities for memory and compute savings. FlashFFTConv speeds up exact FFT convolutions by up to 7.93times over PyTorch and achieves up to 4.4times speedup end-to-end. Given the same compute budget, FlashFFTConv allows Hyena-GPT-s to achieve 2.3 points better perplexity on the PILE and M2-BERT-base to achieve 3.3 points higher GLUE score--matching models with twice the parameter count. FlashFFTConv also achieves 96.1% accuracy on Path-512, a high-resolution vision task where no model had previously achieved better than 50%. Furthermore, partial convolutions enable longer-sequence models--yielding the first DNA model that can process the longest human genes (2.3M base pairs)--and frequency-sparse convolutions speed up pretrained models while maintaining or improving model quality.

  • 4 authors
·
Nov 10, 2023 1

HieraTok: Multi-Scale Visual Tokenizer Improves Image Reconstruction and Generation

In this work, we present HieraTok, a novel multi-scale Vision Transformer (ViT)-based tokenizer that overcomes the inherent limitation of modeling single-scale representations. This is realized through two key designs: (1) multi-scale downsampling applied to the token map generated by the tokenizer encoder, producing a sequence of multi-scale tokens, and (2) a scale-causal attention mechanism that enables the progressive flow of information from low-resolution global semantic features to high-resolution structural details. Coupling these designs, HieraTok achieves significant improvements in both image reconstruction and generation tasks. Under identical settings, the multi-scale visual tokenizer outperforms its single-scale counterpart by a 27.2\% improvement in rFID (1.47 rightarrow 1.07). When integrated into downstream generation frameworks, it achieves a 1.38times faster convergence rate and an 18.9\% boost in gFID (16.4 rightarrow 13.3), which may be attributed to the smoother and more uniformly distributed latent space. Furthermore, by scaling up the tokenizer's training, we demonstrate its potential by a sota rFID of 0.45 and a gFID of 1.82 among ViT tokenizers. To the best of our knowledge, we are the first to introduce multi-scale ViT-based tokenizer in image reconstruction and image generation. We hope our findings and designs advance the ViT-based tokenizers in visual generation tasks.

  • 9 authors
·
Sep 28, 2025

HMAR: Efficient Hierarchical Masked Auto-Regressive Image Generation

Visual Auto-Regressive modeling (VAR) has shown promise in bridging the speed and quality gap between autoregressive image models and diffusion models. VAR reformulates autoregressive modeling by decomposing an image into successive resolution scales. During inference, an image is generated by predicting all the tokens in the next (higher-resolution) scale, conditioned on all tokens in all previous (lower-resolution) scales. However, this formulation suffers from reduced image quality due to the parallel generation of all tokens in a resolution scale; has sequence lengths scaling superlinearly in image resolution; and requires retraining to change the sampling schedule. We introduce Hierarchical Masked Auto-Regressive modeling (HMAR), a new image generation algorithm that alleviates these issues using next-scale prediction and masked prediction to generate high-quality images with fast sampling. HMAR reformulates next-scale prediction as a Markovian process, wherein the prediction of each resolution scale is conditioned only on tokens in its immediate predecessor instead of the tokens in all predecessor resolutions. When predicting a resolution scale, HMAR uses a controllable multi-step masked generation procedure to generate a subset of the tokens in each step. On ImageNet 256x256 and 512x512 benchmarks, HMAR models match or outperform parameter-matched VAR, diffusion, and autoregressive baselines. We develop efficient IO-aware block-sparse attention kernels that allow HMAR to achieve faster training and inference times over VAR by over 2.5x and 1.75x respectively, as well as over 3x lower inference memory footprint. Finally, HMAR yields additional flexibility over VAR; its sampling schedule can be changed without further training, and it can be applied to image editing tasks in a zero-shot manner.

  • 9 authors
·
Jun 4, 2025

SpikMamba: When SNN meets Mamba in Event-based Human Action Recognition

Human action recognition (HAR) plays a key role in various applications such as video analysis, surveillance, autonomous driving, robotics, and healthcare. Most HAR algorithms are developed from RGB images, which capture detailed visual information. However, these algorithms raise concerns in privacy-sensitive environments due to the recording of identifiable features. Event cameras offer a promising solution by capturing scene brightness changes sparsely at the pixel level, without capturing full images. Moreover, event cameras have high dynamic ranges that can effectively handle scenarios with complex lighting conditions, such as low light or high contrast environments. However, using event cameras introduces challenges in modeling the spatially sparse and high temporal resolution event data for HAR. To address these issues, we propose the SpikMamba framework, which combines the energy efficiency of spiking neural networks and the long sequence modeling capability of Mamba to efficiently capture global features from spatially sparse and high a temporal resolution event data. Additionally, to improve the locality of modeling, a spiking window-based linear attention mechanism is used. Extensive experiments show that SpikMamba achieves remarkable recognition performance, surpassing the previous state-of-the-art by 1.45%, 7.22%, 0.15%, and 3.92% on the PAF, HARDVS, DVS128, and E-FAction datasets, respectively. The code is available at https://github.com/Typistchen/SpikMamba.

  • 5 authors
·
Oct 22, 2024

GTA1: GUI Test-time Scaling Agent

Graphical user interface (GUI) agents autonomously operate across platforms (e.g., Linux) to complete tasks by interacting with visual elements. Specifically, a user instruction is decomposed into a sequence of action proposals, each corresponding to an interaction with the GUI. After each action, the agent observes the updated GUI environment to plan the next step. However, two main challenges arise: i) resolving ambiguity in task planning (i.e., the action proposal sequence), where selecting an appropriate plan is non-trivial, as many valid ones may exist; ii) accurately grounding actions in complex and high-resolution interfaces, i.e., precisely interacting with visual targets. This paper investigates the two aforementioned challenges with our GUI Test-time Scaling Agent, namely GTA1. First, to select the most appropriate action proposal, we introduce a test-time scaling method. At each step, we sample multiple candidate action proposals and leverage a judge model to evaluate and select the most suitable one. It trades off computation for better decision quality by concurrent sampling, shortening task execution steps, and improving overall performance. Second, we propose a model that achieves improved accuracy when grounding the selected action proposal to its corresponding visual elements. Our key insight is that reinforcement learning (RL) facilitates visual grounding through inherent objective alignments, rewarding successful clicks on interface elements. Experimentally, our method establishes state-of-the-art performance across diverse benchmarks. For example, GTA1-7B achieves 50.1%, 92.4%, and 67.7% accuracies on Screenspot-Pro, Screenspot-V2, and OSWorld-G, respectively. When paired with a planner applying our test-time scaling strategy, it exhibits state-of-the-art agentic performance (e.g., 45.2% task success rate on OSWorld). We open-source our code and models here.

Salesforce Salesforce
·
Jul 8, 2025 1

LLM Tree Search

This project aims to investigate a novel sequence generation method inspired by the AlphaGo paradigm, adapting it for use with large language models (LLMs). The proposed approach involves creating search trees of different possible completions and evaluating these completions based on model confidence. By considering various paths in the search tree and scoring them according to the model's confidence in each completion, we can generate diverse and high-quality sequences. This research explores the implementation of this paradigm by using confidence as a proxy for response quality akin to beam search vijayakumar2016diverse. The primary goal of this paper is to outline the paradigm and demonstrate its potential, rather than focusing on achieving perfect results. The paper will outline the reasons why we believe this paradigm has the potential to improve LLMs in the following manners: 1) increase output quality, 2) decrease errors, 3) eliminate or reduce the compound error problems, 4) generate diverse and creative completions, 5) allow for iterative problem-solving, and 6) self-training. We expect this approach to yield a set of diverse and coherent sequences, offering insights into balancing exploration and exploitation in sequence generation. Potential applications include creative text generation tasks, such as storytelling and content creation, as well as other natural language processing domains, like machine translation and automated summarization. The goal is that the model will be far more effective as it will be able to consider many possible variations allowing it to find the ideal completion. This research aims to contribute to the understanding of effective search strategies in sequence generation and their impact on generating high-quality, varied textual outputs.

  • 1 authors
·
Oct 24, 2024

Efficiently Modeling Long Sequences with Structured State Spaces

A central goal of sequence modeling is designing a single principled model that can address sequence data across a range of modalities and tasks, particularly on long-range dependencies. Although conventional models including RNNs, CNNs, and Transformers have specialized variants for capturing long dependencies, they still struggle to scale to very long sequences of 10000 or more steps. A promising recent approach proposed modeling sequences by simulating the fundamental state space model (SSM) \( x'(t) = Ax(t) + Bu(t), y(t) = Cx(t) + Du(t) \), and showed that for appropriate choices of the state matrix \( A \), this system could handle long-range dependencies mathematically and empirically. However, this method has prohibitive computation and memory requirements, rendering it infeasible as a general sequence modeling solution. We propose the Structured State Space sequence model (S4) based on a new parameterization for the SSM, and show that it can be computed much more efficiently than prior approaches while preserving their theoretical strengths. Our technique involves conditioning \( A \) with a low-rank correction, allowing it to be diagonalized stably and reducing the SSM to the well-studied computation of a Cauchy kernel. S4 achieves strong empirical results across a diverse range of established benchmarks, including (i) 91\% accuracy on sequential CIFAR-10 with no data augmentation or auxiliary losses, on par with a larger 2-D ResNet, (ii) substantially closing the gap to Transformers on image and language modeling tasks, while performing generation 60times faster (iii) SoTA on every task from the Long Range Arena benchmark, including solving the challenging Path-X task of length 16k that all prior work fails on, while being as efficient as all competitors.

  • 3 authors
·
Oct 30, 2021

An Interdisciplinary Comparison of Sequence Modeling Methods for Next-Element Prediction

Data of sequential nature arise in many application domains in forms of, e.g. textual data, DNA sequences, and software execution traces. Different research disciplines have developed methods to learn sequence models from such datasets: (i) in the machine learning field methods such as (hidden) Markov models and recurrent neural networks have been developed and successfully applied to a wide-range of tasks, (ii) in process mining process discovery techniques aim to generate human-interpretable descriptive models, and (iii) in the grammar inference field the focus is on finding descriptive models in the form of formal grammars. Despite their different focuses, these fields share a common goal - learning a model that accurately describes the behavior in the underlying data. Those sequence models are generative, i.e, they can predict what elements are likely to occur after a given unfinished sequence. So far, these fields have developed mainly in isolation from each other and no comparison exists. This paper presents an interdisciplinary experimental evaluation that compares sequence modeling techniques on the task of next-element prediction on four real-life sequence datasets. The results indicate that machine learning techniques that generally have no aim at interpretability in terms of accuracy outperform techniques from the process mining and grammar inference fields that aim to yield interpretable models.

  • 3 authors
·
Oct 31, 2018

Lost in Tokenization: Context as the Key to Unlocking Biomolecular Understanding in Scientific LLMs

Scientific Large Language Models (Sci-LLMs) have emerged as a promising frontier for accelerating biological discovery. However, these models face a fundamental challenge when processing raw biomolecular sequences: the tokenization dilemma. Whether treating sequences as a specialized language, risking the loss of functional motif information, or as a separate modality, introducing formidable alignment challenges, current strategies fundamentally limit their reasoning capacity. We challenge this sequence-centric paradigm by positing that a more effective strategy is to provide Sci-LLMs with high-level structured context derived from established bioinformatics tools, thereby bypassing the need to interpret low-level noisy sequence data directly. Through a systematic comparison of leading Sci-LLMs on biological reasoning tasks, we tested three input modes: sequence-only, context-only, and a combination of both. Our findings are striking: the context-only approach consistently and substantially outperforms all other modes. Even more revealing, the inclusion of the raw sequence alongside its high-level context consistently degrades performance, indicating that raw sequences act as informational noise, even for models with specialized tokenization schemes. These results suggest that the primary strength of existing Sci-LLMs lies not in their nascent ability to interpret biomolecular syntax from scratch, but in their profound capacity for reasoning over structured, human-readable knowledge. Therefore, we argue for reframing Sci-LLMs not as sequence decoders, but as powerful reasoning engines over expert knowledge. This work lays the foundation for a new class of hybrid scientific AI agents, repositioning the developmental focus from direct sequence interpretation towards high-level knowledge synthesis. The code is available at https://github.com/opendatalab-raiser/CoKE.

  • 13 authors
·
Oct 27, 2025

Diverse Beam Search: Decoding Diverse Solutions from Neural Sequence Models

Neural sequence models are widely used to model time-series data. Equally ubiquitous is the usage of beam search (BS) as an approximate inference algorithm to decode output sequences from these models. BS explores the search space in a greedy left-right fashion retaining only the top-B candidates - resulting in sequences that differ only slightly from each other. Producing lists of nearly identical sequences is not only computationally wasteful but also typically fails to capture the inherent ambiguity of complex AI tasks. To overcome this problem, we propose Diverse Beam Search (DBS), an alternative to BS that decodes a list of diverse outputs by optimizing for a diversity-augmented objective. We observe that our method finds better top-1 solutions by controlling for the exploration and exploitation of the search space - implying that DBS is a better search algorithm. Moreover, these gains are achieved with minimal computational or memory over- head as compared to beam search. To demonstrate the broad applicability of our method, we present results on image captioning, machine translation and visual question generation using both standard quantitative metrics and qualitative human studies. Further, we study the role of diversity for image-grounded language generation tasks as the complexity of the image changes. We observe that our method consistently outperforms BS and previously proposed techniques for diverse decoding from neural sequence models.

  • 7 authors
·
Oct 7, 2016

A Fine-tuning Dataset and Benchmark for Large Language Models for Protein Understanding

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in comprehending protein sequences remains an open question, largely due to the absence of datasets linking protein sequences to descriptive text. Researchers have then attempted to adapt LLMs for protein understanding by integrating a protein sequence encoder with a pre-trained LLM. However, this adaptation raises a fundamental question: "Can LLMs, originally designed for NLP, effectively comprehend protein sequences as a form of language?" Current datasets fall short in addressing this question due to the lack of a direct correlation between protein sequences and corresponding text descriptions, limiting the ability to train and evaluate LLMs for protein understanding effectively. To bridge this gap, we introduce ProteinLMDataset, a dataset specifically designed for further self-supervised pretraining and supervised fine-tuning (SFT) of LLMs to enhance their capability for protein sequence comprehension. Specifically, ProteinLMDataset includes 17.46 billion tokens for pretraining and 893,000 instructions for SFT. Additionally, we present ProteinLMBench, the first benchmark dataset consisting of 944 manually verified multiple-choice questions for assessing the protein understanding capabilities of LLMs. ProteinLMBench incorporates protein-related details and sequences in multiple languages, establishing a new standard for evaluating LLMs' abilities in protein comprehension. The large language model InternLM2-7B, pretrained and fine-tuned on the ProteinLMDataset, outperforms GPT-4 on ProteinLMBench, achieving the highest accuracy score. The dataset and the benchmark are available at https://huggingface.co/datasets/tsynbio/ProteinLMBench.

  • 9 authors
·
Jun 8, 2024

Towards Refining Developer Questions using LLM-Based Named Entity Recognition for Developer Chatroom Conversations

In software engineering chatrooms, communication is often hindered by imprecise questions that cannot be answered. Recognizing key entities can be essential for improving question clarity and facilitating better exchange. However, existing research using natural language processing techniques often overlooks these software-specific nuances. In this paper, we introduce Software-specific Named Entity Recognition, Intent Detection, and Resolution Classification (SENIR), a labeling approach that leverages a Large Language Model to annotate entities, intents, and resolution status in developer chatroom conversations. To offer quantitative guidance for improving question clarity and resolvability, we build a resolution prediction model that leverages SENIR's entity and intent labels along with additional predictive features. We evaluate SENIR on the DISCO dataset using a subset of annotated chatroom dialogues. SENIR achieves an 86% F-score for entity recognition, a 71% F-score for intent detection, and an 89% F-score for resolution status classification. Furthermore, our resolution prediction model, tested with various sampling strategies (random undersampling and oversampling with SMOTE) and evaluation methods (5-fold cross-validation, 10-fold cross-validation, and bootstrapping), demonstrates AUC values ranging from 0.7 to 0.8. Key factors influencing resolution include positive sentiment and entities such as Programming Language and User Variable across multiple intents, while diagnostic entities are more relevant in error-related questions. Moreover, resolution rates vary significantly by intent: questions about API Usage and API Change achieve higher resolution rates, whereas Discrepancy and Review have lower resolution rates. A Chi-Square analysis confirms the statistical significance of these differences.

  • 5 authors
·
Mar 1, 2025

Making the Most of your Model: Methods for Finetuning and Applying Pretrained Transformers

This thesis provides methods and analysis of models which make progress on this goal. The techniques outlined are task agnostic, and should provide benefit when used with nearly any transformer LM. We introduce two new finetuning methods which add new capabilities to the models they are used on. The first adds a recurrence mechanism, which removes the fixed-window sized constraint and improves the efficiency of a transformer decoder. The second allows masked language models (MLMs) to be used for initialization of both the encoder and decoder of a non-autoregressive sequence-to-sequence transformer, opening up generative applications of models which were previously only used for natural language understanding tasks. We also introduce two new techniques for improving the quality of predictions of any transformer decoder without additional finetuning. One, hidden state optimization, can be applied to any transformer decoder to improve the quality of predictions at inference time, especially for few-shot classification. The other, conditional beam search, allows practitioners to search for natural language generation (NLG) model outputs with high likelihood while conditioning on the event that the output is not degenerate (e.g. empty, repetitive, etc.). Finally, we provide theoretical and empirical insights on the divergence of model-likelihood and output quality which has widely been observed in prior work. These insights apply to any model which represents a distribution over text, and apply to language models which are not transformers or even autoregressive. We argue that the NLP community has, to some extent, misunderstood the implications of these findings, and encourage a point of view which has more nuance.

  • 1 authors
·
Aug 28, 2024

Peptide Sequencing Via Protein Language Models

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based platforms able to sequence non-native peptides. Current protein sequencing techniques face limitations in accurately identifying all amino acids, hindering comprehensive proteome analysis. Our method simulates partial sequencing data by selectively masking amino acids that are experimentally difficult to identify in protein sequences from the UniRef database. This targeted masking mimics real-world sequencing limitations. We then modify and finetune a ProtBert derived transformer-based model, for a new downstream task predicting these masked residues, providing an approximation of the complete sequence. Evaluating on three bacterial Escherichia species, we achieve per-amino-acid accuracy up to 90.5% when only four amino acids ([KCYM]) are known. Structural assessment using AlphaFold and TM-score validates the biological relevance of our predictions. The model also demonstrates potential for evolutionary analysis through cross-species performance. This integration of simulated experimental constraints with computational predictions offers a promising avenue for enhancing protein sequence analysis, potentially accelerating advancements in proteomics and structural biology by providing a probabilistic reconstruction of the complete protein sequence from limited experimental data.

  • 12 authors
·
Aug 1, 2024

SynthBA: Reliable Brain Age Estimation Across Multiple MRI Sequences and Resolutions

Brain age is a critical measure that reflects the biological ageing process of the brain. The gap between brain age and chronological age, referred to as brain PAD (Predicted Age Difference), has been utilized to investigate neurodegenerative conditions. Brain age can be predicted using MRIs and machine learning techniques. However, existing methods are often sensitive to acquisition-related variabilities, such as differences in acquisition protocols, scanners, MRI sequences, and resolutions, significantly limiting their application in highly heterogeneous clinical settings. In this study, we introduce Synthetic Brain Age (SynthBA), a robust deep-learning model designed for predicting brain age. SynthBA utilizes an advanced domain randomization technique, ensuring effective operation across a wide array of acquisition-related variabilities. To assess the effectiveness and robustness of SynthBA, we evaluate its predictive capabilities on internal and external datasets, encompassing various MRI sequences and resolutions, and compare it with state-of-the-art techniques. Additionally, we calculate the brain PAD in a large cohort of subjects with Alzheimer's Disease (AD), demonstrating a significant correlation with AD-related measures of cognitive dysfunction. SynthBA holds the potential to facilitate the broader adoption of brain age prediction in clinical settings, where re-training or fine-tuning is often unfeasible. The SynthBA source code and pre-trained models are publicly available at https://github.com/LemuelPuglisi/SynthBA.

  • 6 authors
·
Jun 1, 2024

PoET: A generative model of protein families as sequences-of-sequences

Generative protein language models are a natural way to design new proteins with desired functions. However, current models are either difficult to direct to produce a protein from a specific family of interest, or must be trained on a large multiple sequence alignment (MSA) from the specific family of interest, making them unable to benefit from transfer learning across families. To address this, we propose Protein Evolutionary Transformer (PoET), an autoregressive generative model of whole protein families that learns to generate sets of related proteins as sequences-of-sequences across tens of millions of natural protein sequence clusters. PoET can be used as a retrieval-augmented language model to generate and score arbitrary modifications conditioned on any protein family of interest, and can extrapolate from short context lengths to generalize well even for small families. This is enabled by a unique Transformer layer; we model tokens sequentially within sequences while attending between sequences order invariantly, allowing PoET to scale to context lengths beyond those used during training. In extensive experiments on deep mutational scanning datasets, we show that PoET outperforms existing protein language models and evolutionary sequence models for variant function prediction across proteins of all MSA depths. We also demonstrate PoET's ability to controllably generate new protein sequences.

  • 2 authors
·
Jun 9, 2023

Frame-Recurrent Video Super-Resolution

Recent advances in video super-resolution have shown that convolutional neural networks combined with motion compensation are able to merge information from multiple low-resolution (LR) frames to generate high-quality images. Current state-of-the-art methods process a batch of LR frames to generate a single high-resolution (HR) frame and run this scheme in a sliding window fashion over the entire video, effectively treating the problem as a large number of separate multi-frame super-resolution tasks. This approach has two main weaknesses: 1) Each input frame is processed and warped multiple times, increasing the computational cost, and 2) each output frame is estimated independently conditioned on the input frames, limiting the system's ability to produce temporally consistent results. In this work, we propose an end-to-end trainable frame-recurrent video super-resolution framework that uses the previously inferred HR estimate to super-resolve the subsequent frame. This naturally encourages temporally consistent results and reduces the computational cost by warping only one image in each step. Furthermore, due to its recurrent nature, the proposed method has the ability to assimilate a large number of previous frames without increased computational demands. Extensive evaluations and comparisons with previous methods validate the strengths of our approach and demonstrate that the proposed framework is able to significantly outperform the current state of the art.

  • 3 authors
·
Jan 14, 2018

Order Matters: Sequence to sequence for sets

Sequences have become first class citizens in supervised learning thanks to the resurgence of recurrent neural networks. Many complex tasks that require mapping from or to a sequence of observations can now be formulated with the sequence-to-sequence (seq2seq) framework which employs the chain rule to efficiently represent the joint probability of sequences. In many cases, however, variable sized inputs and/or outputs might not be naturally expressed as sequences. For instance, it is not clear how to input a set of numbers into a model where the task is to sort them; similarly, we do not know how to organize outputs when they correspond to random variables and the task is to model their unknown joint probability. In this paper, we first show using various examples that the order in which we organize input and/or output data matters significantly when learning an underlying model. We then discuss an extension of the seq2seq framework that goes beyond sequences and handles input sets in a principled way. In addition, we propose a loss which, by searching over possible orders during training, deals with the lack of structure of output sets. We show empirical evidence of our claims regarding ordering, and on the modifications to the seq2seq framework on benchmark language modeling and parsing tasks, as well as two artificial tasks -- sorting numbers and estimating the joint probability of unknown graphical models.

  • 3 authors
·
Nov 19, 2015

Mamba-360: Survey of State Space Models as Transformer Alternative for Long Sequence Modelling: Methods, Applications, and Challenges

Sequence modeling is a crucial area across various domains, including Natural Language Processing (NLP), speech recognition, time series forecasting, music generation, and bioinformatics. Recurrent Neural Networks (RNNs) and Long Short Term Memory Networks (LSTMs) have historically dominated sequence modeling tasks like Machine Translation, Named Entity Recognition (NER), etc. However, the advancement of transformers has led to a shift in this paradigm, given their superior performance. Yet, transformers suffer from O(N^2) attention complexity and challenges in handling inductive bias. Several variations have been proposed to address these issues which use spectral networks or convolutions and have performed well on a range of tasks. However, they still have difficulty in dealing with long sequences. State Space Models(SSMs) have emerged as promising alternatives for sequence modeling paradigms in this context, especially with the advent of S4 and its variants, such as S4nd, Hippo, Hyena, Diagnol State Spaces (DSS), Gated State Spaces (GSS), Linear Recurrent Unit (LRU), Liquid-S4, Mamba, etc. In this survey, we categorize the foundational SSMs based on three paradigms namely, Gating architectures, Structural architectures, and Recurrent architectures. This survey also highlights diverse applications of SSMs across domains such as vision, video, audio, speech, language (especially long sequence modeling), medical (including genomics), chemical (like drug design), recommendation systems, and time series analysis, including tabular data. Moreover, we consolidate the performance of SSMs on benchmark datasets like Long Range Arena (LRA), WikiText, Glue, Pile, ImageNet, Kinetics-400, sstv2, as well as video datasets such as Breakfast, COIN, LVU, and various time series datasets. The project page for Mamba-360 work is available on this webpage.https://github.com/badripatro/mamba360.

  • 2 authors
·
Apr 24, 2024 1

Dragonfly: Multi-Resolution Zoom Supercharges Large Visual-Language Model

Recent advances in large multimodal models (LMMs) suggest that higher image resolution enhances the fine-grained understanding of image details, crucial for tasks such as visual commonsense reasoning and analyzing biomedical images. However, increasing input resolution poses two main challenges: 1) It extends the context length required by the language model, leading to inefficiencies and hitting the model's context limit; 2) It increases the complexity of visual features, necessitating more training data or more complex architecture. We introduce Dragonfly, a new LMM architecture that enhances fine-grained visual understanding and reasoning about image regions to address these challenges. Dragonfly employs two key strategies: multi-resolution visual encoding and zoom-in patch selection. These strategies allow the model to process high-resolution images efficiently while maintaining reasonable context length. Our experiments on eight popular benchmarks demonstrate that Dragonfly achieves competitive or better performance compared to other architectures, highlighting the effectiveness of our design. Additionally, we finetuned Dragonfly on biomedical instructions, achieving state-of-the-art results on multiple biomedical tasks requiring fine-grained visual understanding, including 92.3% accuracy on the Path-VQA dataset (compared to 83.3% for Med-Gemini) and the highest reported results on biomedical image captioning. To support model training, we curated a visual instruction-tuning dataset with 5.5 million image-instruction samples in the general domain and 1.4 million samples in the biomedical domain. We also conducted ablation studies to characterize the impact of various architectural designs and image resolutions, providing insights for future research on visual instruction alignment. The codebase and model are available at https://github.com/togethercomputer/Dragonfly.

  • 6 authors
·
Jun 3, 2024

Decoder-Only or Encoder-Decoder? Interpreting Language Model as a Regularized Encoder-Decoder

The sequence-to-sequence (seq2seq) task aims at generating the target sequence based on the given input source sequence. Traditionally, most of the seq2seq task is resolved by the Encoder-Decoder framework which requires an encoder to encode the source sequence and a decoder to generate the target text. Recently, a bunch of new approaches have emerged that apply decoder-only language models directly to the seq2seq task. Despite the significant advancements in applying language models to the seq2seq task, there is still a lack of thorough analysis on the effectiveness of the decoder-only language model architecture. This paper aims to address this gap by conducting a detailed comparison between the encoder-decoder architecture and the decoder-only language model framework through the analysis of a regularized encoder-decoder structure. This structure is designed to replicate all behaviors in the classical decoder-only language model but has an encoder and a decoder making it easier to be compared with the classical encoder-decoder structure. Based on the analysis, we unveil the attention degeneration problem in the language model, namely, as the generation step number grows, less and less attention is focused on the source sequence. To give a quantitative understanding of this problem, we conduct a theoretical sensitivity analysis of the attention output with respect to the source input. Grounded on our analysis, we propose a novel partial attention language model to solve the attention degeneration problem. Experimental results on machine translation, summarization, and data-to-text generation tasks support our analysis and demonstrate the effectiveness of our proposed model.

  • 7 authors
·
Apr 8, 2023

Set-Based Prompting: Provably Solving the Language Model Order Dependency Problem

The development of generative language models that can create long and coherent textual outputs via autoregression has lead to a proliferation of uses and a corresponding sweep of analyses as researches work to determine the limitations of this new paradigm. Unlike humans, these 'Large Language Models' (LLMs) are highly sensitive to small changes in their inputs, leading to unwanted inconsistency in their behavior. One problematic inconsistency when LLMs are used to answer multiple-choice questions or analyze multiple inputs is order dependency: the output of an LLM can (and often does) change significantly when sub-sequences are swapped, despite both orderings being semantically identical. In this paper we present , a technique that guarantees the output of an LLM will not have order dependence on a specified set of sub-sequences. We show that this method provably eliminates order dependency, and that it can be applied to any transformer-based LLM to enable text generation that is unaffected by re-orderings. Delving into the implications of our method, we show that, despite our inputs being out of distribution, the impact on expected accuracy is small, where the expectation is over the order of uniformly chosen shuffling of the candidate responses, and usually significantly less in practice. Thus, can be used as a 'dropped-in' method on fully trained models. Finally, we discuss how our method's success suggests that other strong guarantees can be obtained on LLM performance via modifying the input representations.

  • 5 authors
·
Jun 4, 2024

Find Central Dogma Again

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in AI for other scientific fields, deeper research into biological LLMs has begun to focus on using these models to rediscover important existing biological laws or uncover entirely new patterns in biological sequences.This study leverages GPT-like LLMs to utilize language transfer capabilities to rediscover the genetic code rules of the central dogma. In our experimental design, we transformed the central dogma into a binary classification problem of aligning DNA sequences with protein sequences, where positive examples are matching DNA and protein sequences, and negative examples are non-matching pairs.We first trained a GPT-2 model from scratch using a dataset comprising protein sequences, DNA sequences, and sequences from languages such as English and Chinese. Subsequently, we fine-tuned the model using the English similarity judgment dataset from PAWS-X. When tested on a dataset for DNA and protein sequence alignment judgment, the fine-tuned model achieved a classification accuracy of 76%. The study also analyzed factors contributing to this zero-shot capability, including model training stability and types of training data.This research demonstrates that LLMs can, through the transfer of natural language capabilities and solely relying on the analysis of sequences themselves, rediscover the central dogma without prior knowledge of it. This study opens a new door for AI-driven biological research.

  • 1 authors
·
Feb 10, 2025

SQLNet: Generating Structured Queries From Natural Language Without Reinforcement Learning

Synthesizing SQL queries from natural language is a long-standing open problem and has been attracting considerable interest recently. Toward solving the problem, the de facto approach is to employ a sequence-to-sequence-style model. Such an approach will necessarily require the SQL queries to be serialized. Since the same SQL query may have multiple equivalent serializations, training a sequence-to-sequence-style model is sensitive to the choice from one of them. This phenomenon is documented as the "order-matters" problem. Existing state-of-the-art approaches rely on reinforcement learning to reward the decoder when it generates any of the equivalent serializations. However, we observe that the improvement from reinforcement learning is limited. In this paper, we propose a novel approach, i.e., SQLNet, to fundamentally solve this problem by avoiding the sequence-to-sequence structure when the order does not matter. In particular, we employ a sketch-based approach where the sketch contains a dependency graph so that one prediction can be done by taking into consideration only the previous predictions that it depends on. In addition, we propose a sequence-to-set model as well as the column attention mechanism to synthesize the query based on the sketch. By combining all these novel techniques, we show that SQLNet can outperform the prior art by 9% to 13% on the WikiSQL task.

  • 3 authors
·
Nov 13, 2017