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Oct 27

Resolution-Agnostic Neural Operators for Multi-Rate Sparse-View CT

Sparse-view Computed Tomography (CT) reconstructs images from a limited number of X-ray projections to reduce radiation and scanning time, which is an ill-posed inverse problem. Existing methods achieve high-fidelity reconstructions but overfit to a fixed acquisition setup, failing to generalize well across sampling rates. For example, convolutional neural networks (CNNs) use the same kernels across resolutions, leading to artifacts when data resolution changes. This is a critical limitation in clinical practice, where acquisition sampling settings vary across organs and diagnostic protocols. We propose Computed Tomography neural Operator (CTO), the first neural operator (NO) framework for CT reconstruction. CTO extends learning from fixed discretized grids to continuous function space, enabling a single model to generalize across measurement sampling rates without retraining. We also propose new NO architectural designs for CT: (i) a dual-domain NO architecture in both sinogram and image spaces, capturing complementary spatial-frequency information, and (ii) rotation-equivariant DIScrete-COntinuous convolutions (DISCO) that exploit the rotational structure inherent in tomographic acquisition. Empirically, CTO outperforms CNNs (> 3.4dB PSNR gain) and other baselines in multi-resolution settings across multiple CT datasets. Compared to state-of-the-art diffusion methods, CTO has 500x faster inference with an average 3dB gain. CTO further demonstrates strong out-of-distribution robustness, maintaining gains under cross-dataset transfer and noisy sinogram conditions. Ablation studies also validate each design choice. CTO establishes neural operators as a principled and practical paradigm for flexible, discretization-agnostic CT reconstruction. Our code is available at https://github.com/neuraloperator/sparse_ct.

  • 4 authors
·
Aug 6

Active View Selection with Perturbed Gaussian Ensemble for Tomographic Reconstruction

Sparse-view computed tomography (CT) is critical for reducing radiation exposure to patients. Recent advances in radiative 3D Gaussian Splatting (3DGS) have enabled fast and accurate sparse-view CT reconstruction. Despite these algorithmic advancements, practical reconstruction fidelity remains fundamentally bounded by the quality of the captured data, raising the crucial yet underexplored problem of X-ray active view selection. Existing active view selection methods are primarily designed for natural-light scenes and fail to capture the unique geometric ambiguities and physical attenuation properties inherent in X-ray imaging. In this paper, we present Perturbed Gaussian Ensemble, an active view selection framework that integrates uncertainty modeling with sequential decision-making, tailored for X-ray Gaussian Splatting. Specifically, we identify low-density Gaussian primitives that are likely to be uncertain and apply stochastic density scaling to construct an ensemble of plausible Gaussian density fields. For each candidate projection, we measure the structural variance of the ensemble predictions and select the one with the highest variance as the next best view. Extensive experimental results on arbitrary-trajectory CT benchmarks demonstrate that our density-guided perturbation strategy effectively eliminates geometric artifacts and consistently outperforms existing baselines in progressive tomographic reconstruction under unified view selection protocols.

  • 6 authors
·
Jun 29

Learning to Distill Global Representation for Sparse-View CT

Sparse-view computed tomography (CT) -- using a small number of projections for tomographic reconstruction -- enables much lower radiation dose to patients and accelerated data acquisition. The reconstructed images, however, suffer from strong artifacts, greatly limiting their diagnostic value. Current trends for sparse-view CT turn to the raw data for better information recovery. The resultant dual-domain methods, nonetheless, suffer from secondary artifacts, especially in ultra-sparse view scenarios, and their generalization to other scanners/protocols is greatly limited. A crucial question arises: have the image post-processing methods reached the limit? Our answer is not yet. In this paper, we stick to image post-processing methods due to great flexibility and propose global representation (GloRe) distillation framework for sparse-view CT, termed GloReDi. First, we propose to learn GloRe with Fourier convolution, so each element in GloRe has an image-wide receptive field. Second, unlike methods that only use the full-view images for supervision, we propose to distill GloRe from intermediate-view reconstructed images that are readily available but not explored in previous literature. The success of GloRe distillation is attributed to two key components: representation directional distillation to align the GloRe directions, and band-pass-specific contrastive distillation to gain clinically important details. Extensive experiments demonstrate the superiority of the proposed GloReDi over the state-of-the-art methods, including dual-domain ones. The source code is available at https://github.com/longzilicart/GloReDi.

  • 5 authors
·
Aug 16, 2023

Geometry-Aware Diffusion Approximate Posterior Sampling for Sparse-View and Limited-Angle CT

Sparse-view computed tomography (CT) reduces radiation dose and acquisition time and may mitigate motion artifacts. However, angular undersampling provides insufficient information to determine the image uniquely and stably. Limited-angle CT, arising from restricted angular coverage, produces strongly directional information loss associated with the missing angular range. In both settings, image directions may be strongly observed, weakly constrained, or unobservable, leading to severe ill-posedness and reconstruction ambiguity. Existing diffusion-based approaches incorporate measurement information through likelihood guidance, data-consistency operations, or range-null-space corrections. However, they do not generally use the continuously varying measurement sensitivity of the acquisition to jointly shape both reconstruction updates and stochastic exploration. We propose a geometry-aware diffusion-guided stochastic reconstruction framework for sparse-view and limited-angle CT. Its central component is a regularized noise-weighted pullback metric constructed from the CT forward operator and measurement-noise covariance. This metric continuously adapts both the measurement-aware update and stochastic exploration according to directional measurement sensitivity, suppressing changes along strongly constrained directions while permitting greater exploration along weakly constrained and unobservable directions. We complement this geometry-aware update with a regularized data-consistency correction and approximately null-space-restricted stochastic perturbations, implemented matrix-free using forward and backprojection operations together with conjugate-gradient solves. Experiments on sparse-view, noisy, and limited-angle CT demonstrate competitive reconstruction quality, strong measurement consistency, and spatially resolved empirical uncertainty estimates.

  • 3 authors
·
Oct 4

COBRA2026: a large-scale multicenter pelvic cone-beam computed tomography projection dataset

The COBRA2026 dataset is a large-scale, multicenter resource of raw radiotherapy cone-beam computed tomography (CBCT) acquisitions created for the development and evaluation of conventional and learning-based reconstruction and image-correction methods. It contains data from 867 patients undergoing pelvic radiotherapy at six European centers, acquired using Elekta and Varian imaging systems. For each case, the dataset includes raw projection data, acquisition geometry, calibration and correction information, clinically reconstructed CBCT images, and corresponding planning CT images. Vendor-specific files were anonymized and converted into open formats. Planning CT images were deformably registered to the daily CBCT anatomy, and matched projections were simulated using the corresponding acquisition geometry. All cases underwent visual quality control, and cases with substantial processing or registration errors were excluded. The approximately 950 GB dataset is divided into training, validation, and test sets containing 692, 52, and 123 cases, respectively. Projection stacks and volumetric images are provided as compressed MetaImage files, with geometry and metadata supplied in XML and YAML formats. COBRA2026 supports research on full- and sparse-view reconstruction, low-dose imaging, artifact and scatter correction, motion compensation, and synthetic CT generation. The dataset is released under the CC BY-NC 4.0 license, indexed on Zenodo (doi:10.5281/zenodo.21322350), and accompanied by openly available preprocessing and baseline reconstruction code. It also forms the basis of the COBRA2026 reconstruction challenge.

  • 14 authors
·
Jul 21

RISING a new framework for few-view tomographic image reconstruction with deep learning

This paper proposes a new two-step procedure for sparse-view tomographic image reconstruction. It is called RISING, since it combines an early-stopped Rapid Iterative Solver with a subsequent Iteration Network-based Gaining step. So far, regularized iterative methods have widely been used for X-ray computed tomography image reconstruction from low-sampled data, since they converge to a sparse solution in a suitable domain, as upheld by the Compressed Sensing theory. Unfortunately, their use is practically limited by their high computational cost which imposes to perform only a few iterations in the available time for clinical exams. Data-driven methods, using neural networks to post-process a coarse and noisy image obtained from geometrical algorithms, have been recently studied and appreciated for both their computational speed and accurate reconstructions. However, there is no evidence, neither theoretically nor numerically, that neural networks based algorithms solve the mathematical inverse problem modeling the tomographic reconstruction process. In our two-step approach, the first phase executes very few iterations of a regularized model-based algorithm whereas the second step completes the missing iterations by means of a neural network. The resulting hybrid deep-variational framework preserves the convergence properties of the iterative method and, at the same time, it exploits the computational speed and flexibility of a data-driven approach. Experiments performed on a simulated and a real data set confirm the numerical and visual accuracy of the reconstructed RISING images in short computational times.

  • 3 authors
·
Jan 24, 2022

LM-Gaussian: Boost Sparse-view 3D Gaussian Splatting with Large Model Priors

We aim to address sparse-view reconstruction of a 3D scene by leveraging priors from large-scale vision models. While recent advancements such as 3D Gaussian Splatting (3DGS) have demonstrated remarkable successes in 3D reconstruction, these methods typically necessitate hundreds of input images that densely capture the underlying scene, making them time-consuming and impractical for real-world applications. However, sparse-view reconstruction is inherently ill-posed and under-constrained, often resulting in inferior and incomplete outcomes. This is due to issues such as failed initialization, overfitting on input images, and a lack of details. To mitigate these challenges, we introduce LM-Gaussian, a method capable of generating high-quality reconstructions from a limited number of images. Specifically, we propose a robust initialization module that leverages stereo priors to aid in the recovery of camera poses and the reliable point clouds. Additionally, a diffusion-based refinement is iteratively applied to incorporate image diffusion priors into the Gaussian optimization process to preserve intricate scene details. Finally, we utilize video diffusion priors to further enhance the rendered images for realistic visual effects. Overall, our approach significantly reduces the data acquisition requirements compared to previous 3DGS methods. We validate the effectiveness of our framework through experiments on various public datasets, demonstrating its potential for high-quality 360-degree scene reconstruction. Visual results are on our website.

  • 3 authors
·
Sep 5, 2024

Solving 3D Inverse Problems using Pre-trained 2D Diffusion Models

Diffusion models have emerged as the new state-of-the-art generative model with high quality samples, with intriguing properties such as mode coverage and high flexibility. They have also been shown to be effective inverse problem solvers, acting as the prior of the distribution, while the information of the forward model can be granted at the sampling stage. Nonetheless, as the generative process remains in the same high dimensional (i.e. identical to data dimension) space, the models have not been extended to 3D inverse problems due to the extremely high memory and computational cost. In this paper, we combine the ideas from the conventional model-based iterative reconstruction with the modern diffusion models, which leads to a highly effective method for solving 3D medical image reconstruction tasks such as sparse-view tomography, limited angle tomography, compressed sensing MRI from pre-trained 2D diffusion models. In essence, we propose to augment the 2D diffusion prior with a model-based prior in the remaining direction at test time, such that one can achieve coherent reconstructions across all dimensions. Our method can be run in a single commodity GPU, and establishes the new state-of-the-art, showing that the proposed method can perform reconstructions of high fidelity and accuracy even in the most extreme cases (e.g. 2-view 3D tomography). We further reveal that the generalization capacity of the proposed method is surprisingly high, and can be used to reconstruct volumes that are entirely different from the training dataset.

  • 5 authors
·
Nov 19, 2022

GaussianObject: Just Taking Four Images to Get A High-Quality 3D Object with Gaussian Splatting

Reconstructing and rendering 3D objects from highly sparse views is of critical importance for promoting applications of 3D vision techniques and improving user experience. However, images from sparse views only contain very limited 3D information, leading to two significant challenges: 1) Difficulty in building multi-view consistency as images for matching are too few; 2) Partially omitted or highly compressed object information as view coverage is insufficient. To tackle these challenges, we propose GaussianObject, a framework to represent and render the 3D object with Gaussian splatting, that achieves high rendering quality with only 4 input images. We first introduce techniques of visual hull and floater elimination which explicitly inject structure priors into the initial optimization process for helping build multi-view consistency, yielding a coarse 3D Gaussian representation. Then we construct a Gaussian repair model based on diffusion models to supplement the omitted object information, where Gaussians are further refined. We design a self-generating strategy to obtain image pairs for training the repair model. Our GaussianObject is evaluated on several challenging datasets, including MipNeRF360, OmniObject3D, and OpenIllumination, achieving strong reconstruction results from only 4 views and significantly outperforming previous state-of-the-art methods.

  • 8 authors
·
Feb 15, 2024 4

SpaRP: Fast 3D Object Reconstruction and Pose Estimation from Sparse Views

Open-world 3D generation has recently attracted considerable attention. While many single-image-to-3D methods have yielded visually appealing outcomes, they often lack sufficient controllability and tend to produce hallucinated regions that may not align with users' expectations. In this paper, we explore an important scenario in which the input consists of one or a few unposed 2D images of a single object, with little or no overlap. We propose a novel method, SpaRP, to reconstruct a 3D textured mesh and estimate the relative camera poses for these sparse-view images. SpaRP distills knowledge from 2D diffusion models and finetunes them to implicitly deduce the 3D spatial relationships between the sparse views. The diffusion model is trained to jointly predict surrogate representations for camera poses and multi-view images of the object under known poses, integrating all information from the input sparse views. These predictions are then leveraged to accomplish 3D reconstruction and pose estimation, and the reconstructed 3D model can be used to further refine the camera poses of input views. Through extensive experiments on three datasets, we demonstrate that our method not only significantly outperforms baseline methods in terms of 3D reconstruction quality and pose prediction accuracy but also exhibits strong efficiency. It requires only about 20 seconds to produce a textured mesh and camera poses for the input views. Project page: https://chaoxu.xyz/sparp.

  • 7 authors
·
Aug 19, 2024 2

Glimpse: Generalized Locality for Scalable and Robust CT

Deep learning has become the state-of-the-art approach to medical tomographic imaging. A common approach is to feed the result of a simple inversion, for example the backprojection, to a multiscale convolutional neural network (CNN) which computes the final reconstruction. Despite good results on in-distribution test data, this often results in overfitting certain large-scale structures and poor generalization on out-of-distribution (OOD) samples. Moreover, the memory and computational complexity of multiscale CNNs scale unfavorably with image resolution, making them impractical for application at realistic clinical resolutions. In this paper, we introduce Glimpse, a local coordinate-based neural network for computed tomography which reconstructs a pixel value by processing only the measurements associated with the neighborhood of the pixel. Glimpse significantly outperforms successful CNNs on OOD samples, while achieving comparable or better performance on in-distribution test data and maintaining a memory footprint almost independent of image resolution; 5GB memory suffices to train on 1024x1024 images which is orders of magnitude less than CNNs. Glimpse is fully differentiable and can be used plug-and-play in arbitrary deep learning architectures, enabling feats such as correcting miscalibrated projection orientations. Our implementation and Google Colab demo can be accessed at https://github.com/swing-research/Glimpse.

  • 4 authors
·
Jan 1, 2024

Sinogram upsampling using Primal-Dual UNet for undersampled CT and radial MRI reconstruction

Computed tomography and magnetic resonance imaging are two widely used clinical imaging modalities for non-invasive diagnosis. However, both of these modalities come with certain problems. CT uses harmful ionising radiation, and MRI suffers from slow acquisition speed. Both problems can be tackled by undersampling, such as sparse sampling. However, such undersampled data leads to lower resolution and introduces artefacts. Several techniques, including deep learning based methods, have been proposed to reconstruct such data. However, the undersampled reconstruction problem for these two modalities was always considered as two different problems and tackled separately by different research works. This paper proposes a unified solution for both sparse CT and undersampled radial MRI reconstruction, achieved by applying Fourier transform-based pre-processing on the radial MRI and then finally reconstructing both modalities using sinogram upsampling combined with filtered back-projection. The Primal-Dual network is a deep learning based method for reconstructing sparsely-sampled CT data. This paper introduces Primal-Dual UNet, which improves the Primal-Dual network in terms of accuracy and reconstruction speed. The proposed method resulted in an average SSIM of 0.932\textpm0.021 while performing sparse CT reconstruction for fan-beam geometry with a sparsity level of 16, achieving a statistically significant improvement over the previous model, which resulted in 0.919\textpm0.016. Furthermore, the proposed model resulted in 0.903\textpm0.019 and 0.957\textpm0.023 average SSIM while reconstructing undersampled brain and abdominal MRI data with an acceleration factor of 16, respectively - statistically significant improvements over the original model, which resulted in 0.867\textpm0.025 and 0.949\textpm0.025.

  • 5 authors
·
Dec 26, 2021

AIM 2024 Sparse Neural Rendering Challenge: Dataset and Benchmark

Recent developments in differentiable and neural rendering have made impressive breakthroughs in a variety of 2D and 3D tasks, e.g. novel view synthesis, 3D reconstruction. Typically, differentiable rendering relies on a dense viewpoint coverage of the scene, such that the geometry can be disambiguated from appearance observations alone. Several challenges arise when only a few input views are available, often referred to as sparse or few-shot neural rendering. As this is an underconstrained problem, most existing approaches introduce the use of regularisation, together with a diversity of learnt and hand-crafted priors. A recurring problem in sparse rendering literature is the lack of an homogeneous, up-to-date, dataset and evaluation protocol. While high-resolution datasets are standard in dense reconstruction literature, sparse rendering methods often evaluate with low-resolution images. Additionally, data splits are inconsistent across different manuscripts, and testing ground-truth images are often publicly available, which may lead to over-fitting. In this work, we propose the Sparse Rendering (SpaRe) dataset and benchmark. We introduce a new dataset that follows the setup of the DTU MVS dataset. The dataset is composed of 97 new scenes based on synthetic, high-quality assets. Each scene has up to 64 camera views and 7 lighting configurations, rendered at 1600x1200 resolution. We release a training split of 82 scenes to foster generalizable approaches, and provide an online evaluation platform for the validation and test sets, whose ground-truth images remain hidden. We propose two different sparse configurations (3 and 9 input images respectively). This provides a powerful and convenient tool for reproducible evaluation, and enable researchers easy access to a public leaderboard with the state-of-the-art performance scores. Available at: https://sparebenchmark.github.io/

  • 6 authors
·
Sep 23, 2024 2

Sparse-to-Complete: From Sparse Image Captures to Complete 3D Scenes

We introduce S2C-3D, a novel sparse-view 3D reconstruction framework for high-fidelity and complete scene reconstruction from as few as six to eight images. Our framework features three components: a specialized diffusion model for scene-specific image restoration, a training-free view-consistency conditioned sampling process in the diffusion model for refined Gaussian optimization, and a camera trajectory planning scheme to ensure comprehensive scene coverage. The specialized diffusion model is developed by finetuning a pretrained architecture on the input views and their corresponding degraded counterparts. The adaptation to the scene distribution allows the model to repair Gaussian renderings while effectively eliminating domain gaps. Meanwhile, the trajectory planning scheme optimizes scene coverage by connecting each newly sampled camera to its two nearest neighbors. By iteratively constructing paths and retaining only those that significantly enhance visibility, the scheme establishes a trajectory that covers the entire scene. To address multi-view conflicts, the view-consistency conditioned sampling process quantifies the consistency between neighboring repaired images. This information is injected as a condition into the sampling process of the frozen diffusion model, facilitating the generation of view-consistent images without additional training. Consequently, our approach produces high-fidelity 3D Gaussians that are robust to artifacts. Experimental results demonstrate that S2C-3D outperforms state-of-the-art methods, constructing high-quality scenes that are free from missing regions, blurring, or other artifacts with very sparse inputs. The source code and data are available at https://gapszju.github.io/S2C-3D.

  • 4 authors
·
May 6

I^3Net: Inter-Intra-slice Interpolation Network for Medical Slice Synthesis

Medical imaging is limited by acquisition time and scanning equipment. CT and MR volumes, reconstructed with thicker slices, are anisotropic with high in-plane resolution and low through-plane resolution. We reveal an intriguing phenomenon that due to the mentioned nature of data, performing slice-wise interpolation from the axial view can yield greater benefits than performing super-resolution from other views. Based on this observation, we propose an Inter-Intra-slice Interpolation Network (I^3Net), which fully explores information from high in-plane resolution and compensates for low through-plane resolution. The through-plane branch supplements the limited information contained in low through-plane resolution from high in-plane resolution and enables continual and diverse feature learning. In-plane branch transforms features to the frequency domain and enforces an equal learning opportunity for all frequency bands in a global context learning paradigm. We further propose a cross-view block to take advantage of the information from all three views online. Extensive experiments on two public datasets demonstrate the effectiveness of I^3Net, and noticeably outperforms state-of-the-art super-resolution, video frame interpolation and slice interpolation methods by a large margin. We achieve 43.90dB in PSNR, with at least 1.14dB improvement under the upscale factor of times2 on MSD dataset with faster inference. Code is available at https://github.com/DeepMed-Lab-ECNU/Medical-Image-Reconstruction.

  • 5 authors
·
May 4, 2024

Sparse3D: Distilling Multiview-Consistent Diffusion for Object Reconstruction from Sparse Views

Reconstructing 3D objects from extremely sparse views is a long-standing and challenging problem. While recent techniques employ image diffusion models for generating plausible images at novel viewpoints or for distilling pre-trained diffusion priors into 3D representations using score distillation sampling (SDS), these methods often struggle to simultaneously achieve high-quality, consistent, and detailed results for both novel-view synthesis (NVS) and geometry. In this work, we present Sparse3D, a novel 3D reconstruction method tailored for sparse view inputs. Our approach distills robust priors from a multiview-consistent diffusion model to refine a neural radiance field. Specifically, we employ a controller that harnesses epipolar features from input views, guiding a pre-trained diffusion model, such as Stable Diffusion, to produce novel-view images that maintain 3D consistency with the input. By tapping into 2D priors from powerful image diffusion models, our integrated model consistently delivers high-quality results, even when faced with open-world objects. To address the blurriness introduced by conventional SDS, we introduce the category-score distillation sampling (C-SDS) to enhance detail. We conduct experiments on CO3DV2 which is a multi-view dataset of real-world objects. Both quantitative and qualitative evaluations demonstrate that our approach outperforms previous state-of-the-art works on the metrics regarding NVS and geometry reconstruction.

  • 6 authors
·
Aug 27, 2023

SparSplat: Fast Multi-View Reconstruction with Generalizable 2D Gaussian Splatting

Recovering 3D information from scenes via multi-view stereo reconstruction (MVS) and novel view synthesis (NVS) is inherently challenging, particularly in scenarios involving sparse-view setups. The advent of 3D Gaussian Splatting (3DGS) enabled real-time, photorealistic NVS. Following this, 2D Gaussian Splatting (2DGS) leveraged perspective accurate 2D Gaussian primitive rasterization to achieve accurate geometry representation during rendering, improving 3D scene reconstruction while maintaining real-time performance. Recent approaches have tackled the problem of sparse real-time NVS using 3DGS within a generalizable, MVS-based learning framework to regress 3D Gaussian parameters. Our work extends this line of research by addressing the challenge of generalizable sparse 3D reconstruction and NVS jointly, and manages to perform successfully at both tasks. We propose an MVS-based learning pipeline that regresses 2DGS surface element parameters in a feed-forward fashion to perform 3D shape reconstruction and NVS from sparse-view images. We further show that our generalizable pipeline can benefit from preexisting foundational multi-view deep visual features. The resulting model attains the state-of-the-art results on the DTU sparse 3D reconstruction benchmark in terms of Chamfer distance to ground-truth, as-well as state-of-the-art NVS. It also demonstrates strong generalization on the BlendedMVS and Tanks and Temples datasets. We note that our model outperforms the prior state-of-the-art in feed-forward sparse view reconstruction based on volume rendering of implicit representations, while offering an almost 2 orders of magnitude higher inference speed.

  • 3 authors
·
May 4, 2025

VidSplat: Gaussian Splatting Reconstruction with Geometry-Guided Video Diffusion Priors

Gaussian Splatting has achieved remarkable progress in multi-view surface reconstruction, yet it exhibits notable degradation when only few views are available. Although recent efforts alleviate this issue by enhancing multi-view consistency to produce plausible surfaces, they struggle to infer unseen, occluded, or weakly constrained regions beyond the input coverage. To address this limitation, we present VidSplat, a training-free generative reconstruction framework that leverages powerful video diffusion priors to iteratively synthesize novel views that compensate for missing input coverage, and thereby recover complete 3D scenes from sparse inputs. Specifically, we tackle two key challenges that enable the effective integration of generation and reconstruction. First, for 3D consistent generation, we elaborate a training-free, stage-wise denoising strategy that adaptively guides the denoising direction toward the underlying geometry using the rendered RGB and mask images. Second, to enhance the reconstruction, we develop an iterative mechanism that samples camera trajectories, explores unobserved regions, synthesizes novel views, and supplements training through confidence weighted refinement. VidSplat performs robustly to sparse input and even a single image. Extensive experiments on widely used benchmarks demonstrate our superior performance in sparse-view scene reconstruction.

  • 8 authors
·
May 11

MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomography

We present MInDI-3D (Medical Inversion by Direct Iteration in 3D), the first 3D conditional diffusion-based model for real-world sparse-view Cone Beam Computed Tomography (CBCT) artefact removal, aiming to reduce imaging radiation exposure. A key contribution is extending the "InDI" concept from 2D to a full 3D volumetric approach for medical images, implementing an iterative denoising process that refines the CBCT volume directly from sparse-view input. A further contribution is the generation of a large pseudo-CBCT dataset (16,182) from chest CT volumes of the CT-RATE public dataset to robustly train MInDI-3D. We performed a comprehensive evaluation, including quantitative metrics, scalability analysis, generalisation tests, and a clinical assessment by 11 clinicians. Our results show MInDI-3D's effectiveness, achieving a 12.96 (6.10) dB PSNR gain over uncorrected scans with only 50 projections on the CT-RATE pseudo-CBCT (independent real-world) test set and enabling an 8x reduction in imaging radiation exposure. We demonstrate its scalability by showing that performance improves with more training data. Importantly, MInDI-3D matches the performance of a 3D U-Net on real-world scans from 16 cancer patients across distortion and task-based metrics. It also generalises to new CBCT scanner geometries. Clinicians rated our model as sufficient for patient positioning across all anatomical sites and found it preserved lung tumour boundaries well.

  • 10 authors
·
Aug 13, 2025

Multi-view X-ray Image Synthesis with Multiple Domain Disentanglement from CT Scans

X-ray images play a vital role in the intraoperative processes due to their high resolution and fast imaging speed and greatly promote the subsequent segmentation, registration and reconstruction. However, over-dosed X-rays superimpose potential risks to human health to some extent. Data-driven algorithms from volume scans to X-ray images are restricted by the scarcity of paired X-ray and volume data. Existing methods are mainly realized by modelling the whole X-ray imaging procedure. In this study, we propose a learning-based approach termed CT2X-GAN to synthesize the X-ray images in an end-to-end manner using the content and style disentanglement from three different image domains. Our method decouples the anatomical structure information from CT scans and style information from unpaired real X-ray images/ digital reconstructed radiography (DRR) images via a series of decoupling encoders. Additionally, we introduce a novel consistency regularization term to improve the stylistic resemblance between synthesized X-ray images and real X-ray images. Meanwhile, we also impose a supervised process by computing the similarity of computed real DRR and synthesized DRR images. We further develop a pose attention module to fully strengthen the comprehensive information in the decoupled content code from CT scans, facilitating high-quality multi-view image synthesis in the lower 2D space. Extensive experiments were conducted on the publicly available CTSpine1K dataset and achieved 97.8350, 0.0842 and 3.0938 in terms of FID, KID and defined user-scored X-ray similarity, respectively. In comparison with 3D-aware methods (pi-GAN, EG3D), CT2X-GAN is superior in improving the synthesis quality and realistic to the real X-ray images.

  • 9 authors
·
Apr 18, 2024

CoherentGS: Sparse Novel View Synthesis with Coherent 3D Gaussians

The field of 3D reconstruction from images has rapidly evolved in the past few years, first with the introduction of Neural Radiance Field (NeRF) and more recently with 3D Gaussian Splatting (3DGS). The latter provides a significant edge over NeRF in terms of the training and inference speed, as well as the reconstruction quality. Although 3DGS works well for dense input images, the unstructured point-cloud like representation quickly overfits to the more challenging setup of extremely sparse input images (e.g., 3 images), creating a representation that appears as a jumble of needles from novel views. To address this issue, we propose regularized optimization and depth-based initialization. Our key idea is to introduce a structured Gaussian representation that can be controlled in 2D image space. We then constraint the Gaussians, in particular their position, and prevent them from moving independently during optimization. Specifically, we introduce single and multiview constraints through an implicit convolutional decoder and a total variation loss, respectively. With the coherency introduced to the Gaussians, we further constrain the optimization through a flow-based loss function. To support our regularized optimization, we propose an approach to initialize the Gaussians using monocular depth estimates at each input view. We demonstrate significant improvements compared to the state-of-the-art sparse-view NeRF-based approaches on a variety of scenes.

  • 7 authors
·
Mar 28, 2024

Puzzle Similarity: A Perceptually-guided No-Reference Metric for Artifact Detection in 3D Scene Reconstructions

Modern reconstruction techniques can effectively model complex 3D scenes from sparse 2D views. However, automatically assessing the quality of novel views and identifying artifacts is challenging due to the lack of ground truth images and the limitations of no-reference image metrics in predicting detailed artifact maps. The absence of such quality metrics hinders accurate predictions of the quality of generated views and limits the adoption of post-processing techniques, such as inpainting, to enhance reconstruction quality. In this work, we propose a new no-reference metric, Puzzle Similarity, which is designed to localize artifacts in novel views. Our approach utilizes image patch statistics from the input views to establish a scene-specific distribution that is later used to identify poorly reconstructed regions in the novel views. We test and evaluate our method in the context of 3D reconstruction; to this end, we collected a novel dataset of human quality assessment in unseen reconstructed views. Through this dataset, we demonstrate that our method can not only successfully localize artifacts in novel views, correlating with human assessment, but do so without direct references. Surprisingly, our metric outperforms both no-reference metrics and popular full-reference image metrics. We can leverage our new metric to enhance applications like automatic image restoration, guided acquisition, or 3D reconstruction from sparse inputs.

  • 3 authors
·
Nov 26, 2024

MCDIP-ADMM: Overcoming Overfitting in DIP-based CT reconstruction

This paper investigates the application of unsupervised learning methods for computed tomography (CT) reconstruction. To motivate our work, we review several existing priors, namely the truncated Gaussian prior, the l_1 prior, the total variation prior, and the deep image prior (DIP). We find that DIP outperforms the other three priors in terms of representational capability and visual performance. However, the performance of DIP deteriorates when the number of iterations exceeds a certain threshold due to overfitting. To address this issue, we propose a novel method (MCDIP-ADMM) based on Multi-Code Deep Image Prior and plug-and-play Alternative Direction Method of Multipliers. Specifically, MCDIP utilizes multiple latent codes to generate a series of feature maps at an intermediate layer within a generator model. These maps are then composed with trainable weights, representing the complete image prior. Experimental results demonstrate the superior performance of the proposed MCDIP-ADMM compared to three existing competitors. In the case of parallel beam projection with Gaussian noise, MCDIP-ADMM achieves an average improvement of 4.3 dB over DIP, 1.7 dB over ADMM DIP-WTV, and 1.2 dB over PnP-DIP in terms of PSNR. Similarly, for fan-beam projection with Poisson noise, MCDIP-ADMM achieves an average improvement of 3.09 dB over DIP, 1.86 dB over ADMM DIP-WTV, and 0.84 dB over PnP-DIP in terms of PSNR.

  • 2 authors
·
Apr 7, 2023

LSRM: High-Fidelity Object-Centric Reconstruction via Scaled Context Windows

We introduce the Large Sparse Reconstruction Model to study how scaling transformer context windows impacts feed-forward 3D reconstruction. Although recent object-centric feed-forward methods deliver robust, high-quality reconstruction, they still lag behind dense-view optimization in recovering fine-grained texture and appearance. We show that expanding the context window -- by substantially increasing the number of active object and image tokens -- remarkably narrows this gap and enables high-fidelity 3D object reconstruction and inverse rendering. To scale effectively, we adapt native sparse attention in our architecture design, unlocking its capacity for 3D reconstruction with three key contributions: (1) an efficient coarse-to-fine pipeline that focuses computation on informative regions by predicting sparse high-resolution residuals; (2) a 3D-aware spatial routing mechanism that establishes accurate 2D-3D correspondences using explicit geometric distances rather than standard attention scores; and (3) a custom block-aware sequence parallelism strategy utilizing an All-gather-KV protocol to balance dynamic, sparse workloads across GPUs. As a result, LSRM handles 20x more object tokens and >2x more image tokens than prior state-of-the-art (SOTA) methods. Extensive evaluations on standard novel-view synthesis benchmarks show substantial gains over the current SOTA, yielding 2.5 dB higher PSNR and 40% lower LPIPS. Furthermore, when extending LSRM to inverse rendering tasks, qualitative and quantitative evaluations on widely-used benchmarks demonstrate consistent improvements in texture and geometry details, achieving an LPIPS that matches or exceeds that of SOTA dense-view optimization methods. Code and model will be released on our project page.

  • 4 authors
·
Apr 5

VascuSR: Iterative Anatomy-Aware Diffusion for CT Super-Resolution

Generative super-resolution (SR) can recover sharp detail in computed tomography (CT) images from severely downsampled observations, but the missing high-frequency content is not uniquely determined by the low-resolution input. Consequently, visually plausible reconstructions may contain anatomically unsupported vascular detail, such as missing, spurious, or incorrectly connected vessels. To overcome this challenge, we introduce VascuSR, an iterative anatomy-aware diffusion framework that combines image reconstruction with explicit 3D vascular guidance. First, to provide richer anatomical guidance, we use an explicit 3D vascular representation that captures structural information beyond individual slices. This representation also simplifies vascular refinement by allowing a lightweight 3D generative refiner to focus on vascular structure rather than complex CT appearance. Second, to guide slice-wise SR, a lightweight anatomy controller injects the refined structure into the diffusion decoder, while iterative feedback updates this guidance from each new SR volume. On re-annotated MSD Task08 and HVM datasets, VascuSR outperforms interpolation and learning-based SR baselines in segmentation accuracy (Dice and clDice) and 3D vascular structure (connectivity and mean centerline distance), while maintaining image quality comparable to its SR backbone. Compared with learning-based baselines, VascuSR reduces class-averaged connected-component counts by over 20% on both datasets and mean centerline distance by over 10% on MSD.

  • 5 authors
·
Oct 13 2

GSFixer: Improving 3D Gaussian Splatting with Reference-Guided Video Diffusion Priors

Reconstructing 3D scenes using 3D Gaussian Splatting (3DGS) from sparse views is an ill-posed problem due to insufficient information, often resulting in noticeable artifacts. While recent approaches have sought to leverage generative priors to complete information for under-constrained regions, they struggle to generate content that remains consistent with input observations. To address this challenge, we propose GSFixer, a novel framework designed to improve the quality of 3DGS representations reconstructed from sparse inputs. The core of our approach is the reference-guided video restoration model, built upon a DiT-based video diffusion model trained on paired artifact 3DGS renders and clean frames with additional reference-based conditions. Considering the input sparse views as references, our model integrates both 2D semantic features and 3D geometric features of reference views extracted from the visual geometry foundation model, enhancing the semantic coherence and 3D consistency when fixing artifact novel views. Furthermore, considering the lack of suitable benchmarks for 3DGS artifact restoration evaluation, we present DL3DV-Res which contains artifact frames rendered using low-quality 3DGS. Extensive experiments demonstrate our GSFixer outperforms current state-of-the-art methods in 3DGS artifact restoration and sparse-view 3D reconstruction. Project page: https://github.com/GVCLab/GSFixer.

  • 9 authors
·
Aug 13, 2025 2

Sparse-view Pose Estimation and Reconstruction via Analysis by Generative Synthesis

Inferring the 3D structure underlying a set of multi-view images typically requires solving two co-dependent tasks -- accurate 3D reconstruction requires precise camera poses, and predicting camera poses relies on (implicitly or explicitly) modeling the underlying 3D. The classical framework of analysis by synthesis casts this inference as a joint optimization seeking to explain the observed pixels, and recent instantiations learn expressive 3D representations (e.g., Neural Fields) with gradient-descent-based pose refinement of initial pose estimates. However, given a sparse set of observed views, the observations may not provide sufficient direct evidence to obtain complete and accurate 3D. Moreover, large errors in pose estimation may not be easily corrected and can further degrade the inferred 3D. To allow robust 3D reconstruction and pose estimation in this challenging setup, we propose SparseAGS, a method that adapts this analysis-by-synthesis approach by: a) including novel-view-synthesis-based generative priors in conjunction with photometric objectives to improve the quality of the inferred 3D, and b) explicitly reasoning about outliers and using a discrete search with a continuous optimization-based strategy to correct them. We validate our framework across real-world and synthetic datasets in combination with several off-the-shelf pose estimation systems as initialization. We find that it significantly improves the base systems' pose accuracy while yielding high-quality 3D reconstructions that outperform the results from current multi-view reconstruction baselines.

  • 2 authors
·
Dec 4, 2024

SparseGS-W: Sparse-View 3D Gaussian Splatting in the Wild with Generative Priors

Synthesizing novel views of large-scale scenes from unconstrained in-the-wild images is an important but challenging task in computer vision. Existing methods, which optimize per-image appearance and transient occlusion through implicit neural networks from dense training views (approximately 1000 images), struggle to perform effectively under sparse input conditions, resulting in noticeable artifacts. To this end, we propose SparseGS-W, a novel framework based on 3D Gaussian Splatting that enables the reconstruction of complex outdoor scenes and handles occlusions and appearance changes with as few as five training images. We leverage geometric priors and constrained diffusion priors to compensate for the lack of multi-view information from extremely sparse input. Specifically, we propose a plug-and-play Constrained Novel-View Enhancement module to iteratively improve the quality of rendered novel views during the Gaussian optimization process. Furthermore, we propose an Occlusion Handling module, which flexibly removes occlusions utilizing the inherent high-quality inpainting capability of constrained diffusion priors. Both modules are capable of extracting appearance features from any user-provided reference image, enabling flexible modeling of illumination-consistent scenes. Extensive experiments on the PhotoTourism and Tanks and Temples datasets demonstrate that SparseGS-W achieves state-of-the-art performance not only in full-reference metrics, but also in commonly used non-reference metrics such as FID, ClipIQA, and MUSIQ.

  • 5 authors
·
Mar 25, 2025

GLINT: Sparsely Gated Vision-Language Alignment for Fine-Grained Radiology Representations

Vision-language models (VLMs) for radiology have emerged as a scalable paradigm by leveraging image-report pairs naturally produced in clinical workflows. However, this pairing reveals a mismatch in scale: each finding occupies only a small region of the image, yet supervision is provided only at the global image-report level. This poses a central challenge: prior approaches spread weight densely across all patches rather than concentrating on the sparse subset relevant to a given query. To address this, we present GLINT (Gated Language-Image alignmeNT), a framework that explicitly models this sparse correspondence. On the alignment side, we introduce Sparsely Gated Alignment, a novel architecture in which a sigmoid gate over a separate gate embedding space activates only the patches relevant to each textual query, enforcing explicit sparsity. On the representation side, we add Dense Feature Regularization, which anchors the trainable encoder's intermediate features to a frozen self-supervised learning (SSL) teacher, preserving the fine-grained patch features that the gate relies on. The same recipe applies to both 2D chest X-ray (CXR) and 3D chest computed tomography (CT), built with DINOv3 and V-JEPA 2.1, respectively. GLINT enables zero-shot classification, grounding, and segmentation from free-text queries, and to our knowledge is the first to demonstrate zero-shot segmentation on 3D CT volumes without mask supervision. Notably, the most pronounced gains arise on zero-shot grounding and segmentation, where sparse, query-specific localization is required, consistent with our design intent. In downstream evaluation, GLINT outperforms both SSL encoders and medical VLMs on classification, report generation, and segmentation.

  • 9 authors
·
Jun 1

SimCroP: Radiograph Representation Learning with Similarity-driven Cross-granularity Pre-training

Medical vision-language pre-training shows great potential in learning representative features from massive paired radiographs and reports. However, in computed tomography (CT) scans, the distribution of lesions which contain intricate structures is characterized by spatial sparsity. Besides, the complex and implicit relationships between different pathological descriptions in each sentence of the report and their corresponding sub-regions in radiographs pose additional challenges. In this paper, we propose a Similarity-Driven Cross-Granularity Pre-training (SimCroP) framework on chest CTs, which combines similarity-driven alignment and cross-granularity fusion to improve radiograph interpretation. We first leverage multi-modal masked modeling to optimize the encoder for understanding precise low-level semantics from radiographs. Then, similarity-driven alignment is designed to pre-train the encoder to adaptively select and align the correct patches corresponding to each sentence in reports. The cross-granularity fusion module integrates multimodal information across instance level and word-patch level, which helps the model better capture key pathology structures in sparse radiographs, resulting in improved performance for multi-scale downstream tasks. SimCroP is pre-trained on a large-scale paired CT-reports dataset and validated on image classification and segmentation tasks across five public datasets. Experimental results demonstrate that SimCroP outperforms both cutting-edge medical self-supervised learning methods and medical vision-language pre-training methods. Codes and models are available at https://github.com/ToniChopp/SimCroP.

  • 11 authors
·
Sep 10, 2025

TriSplat: Simulation-Ready Feed-Forward 3D Scene Reconstruction

Sparse-view 3D reconstruction is increasingly addressed with feed-forward splatting networks that predict explicit primitives directly from images. Yet most existing methods remain centered on Gaussian primitives and expose surfaces only indirectly: extracting a usable mesh for downstream simulation, physics reasoning, or embodied interaction still requires expensive post-hoc steps that break the feed-forward promise. This limitation is especially pronounced in pose-free settings, where scene structure and camera parameters must be estimated jointly from sparse observations. We present TriSplat, a feed-forward reconstruction network that represents scenes with oriented triangle primitives and directly exports simulation-ready mesh scenes from a single forward pass. Given input images, the network predicts local 3D point maps, triangle attributes, camera poses, and optional intrinsics. Rather than regressing triangle orientation as an unconstrained latent variable, our approach constructs geometry normals from the predicted point maps, refines them with an image-conditioned normal head, and converts them into stable local frames for triangle parameterization. A mono-normal bootstrap schedule further stabilizes early training, while opacity and blur scheduling progressively sharpens the learned surface representation for direct mesh extraction. Experiments on RealEstate10K and DL3DV show that this representation produces more geometry-faithful reconstructions than Gaussian feed-forward baselines while maintaining competitive novel-view rendering quality. Because the rendering primitives are themselves surface triangles, the output can be directly ingested by physics engines, collision detectors, and standard rendering pipelines without any conversion, making it a practical simulation-ready solution for feed-forward 3D scene reconstruction.

NovelGS: Consistent Novel-view Denoising via Large Gaussian Reconstruction Model

We introduce NovelGS, a diffusion model for Gaussian Splatting (GS) given sparse-view images. Recent works leverage feed-forward networks to generate pixel-aligned Gaussians, which could be fast rendered. Unfortunately, the method was unable to produce satisfactory results for areas not covered by the input images due to the formulation of these methods. In contrast, we leverage the novel view denoising through a transformer-based network to generate 3D Gaussians. Specifically, by incorporating both conditional views and noisy target views, the network predicts pixel-aligned Gaussians for each view. During training, the rendered target and some additional views of the Gaussians are supervised. During inference, the target views are iteratively rendered and denoised from pure noise. Our approach demonstrates state-of-the-art performance in addressing the multi-view image reconstruction challenge. Due to generative modeling of unseen regions, NovelGS effectively reconstructs 3D objects with consistent and sharp textures. Experimental results on publicly available datasets indicate that NovelGS substantially surpasses existing image-to-3D frameworks, both qualitatively and quantitatively. We also demonstrate the potential of NovelGS in generative tasks, such as text-to-3D and image-to-3D, by integrating it with existing multiview diffusion models. We will make the code publicly accessible.

  • 7 authors
·
Nov 24, 2024

RSTAR: Rotational Streak Artifact Reduction in 4D CBCT using Separable and Circular Convolutions

Four-dimensional cone-beam computed tomography (4D CBCT) provides respiration-resolved images and can be used for image-guided radiation therapy. However, the ability to reveal respiratory motion comes at the cost of image artifacts. As raw projection data are sorted into multiple respiratory phases, the cone-beam projections become much sparser and the reconstructed 4D CBCT images will be covered by severe streak artifacts. Although several deep learning-based methods have been proposed to address this issue, most algorithms employ 2D network models as backbones, neglecting the intrinsic structural priors within 4D CBCT images. In this paper, we first explore the origin and appearance of streak artifacts in 4D CBCT images. We find that streak artifacts exhibit a unique rotational motion along with the patient's respiration, distinguishable from diaphragm-driven respiratory motion in the spatiotemporal domain. Therefore, we propose a novel 4D neural network model, RSTAR4D-Net, designed to address Rotational STreak Artifact Reduction by integrating the spatial and temporal information within 4D CBCT images. Specifically, we overcome the computational and training difficulties of a 4D neural network. The specially designed model adopts an efficient implementation of 4D convolutions to reduce computational costs and thus can process the whole 4D image in one pass. Additionally, a Tetris training strategy pertinent to the separable 4D convolutions is proposed to effectively train the model using limited 4D training samples. Extensive experiments substantiate the effectiveness of our proposed method, and the RSTAR4D-Net shows superior performance compared to other methods. The source code and dynamic demos are available at https://github.com/ivy9092111111/RSTAR.

  • 9 authors
·
Mar 24, 2024

Decompositional Neural Scene Reconstruction with Generative Diffusion Prior

Decompositional reconstruction of 3D scenes, with complete shapes and detailed texture of all objects within, is intriguing for downstream applications but remains challenging, particularly with sparse views as input. Recent approaches incorporate semantic or geometric regularization to address this issue, but they suffer significant degradation in underconstrained areas and fail to recover occluded regions. We argue that the key to solving this problem lies in supplementing missing information for these areas. To this end, we propose DP-Recon, which employs diffusion priors in the form of Score Distillation Sampling (SDS) to optimize the neural representation of each individual object under novel views. This provides additional information for the underconstrained areas, but directly incorporating diffusion prior raises potential conflicts between the reconstruction and generative guidance. Therefore, we further introduce a visibility-guided approach to dynamically adjust the per-pixel SDS loss weights. Together these components enhance both geometry and appearance recovery while remaining faithful to input images. Extensive experiments across Replica and ScanNet++ demonstrate that our method significantly outperforms SOTA methods. Notably, it achieves better object reconstruction under 10 views than the baselines under 100 views. Our method enables seamless text-based editing for geometry and appearance through SDS optimization and produces decomposed object meshes with detailed UV maps that support photorealistic Visual effects (VFX) editing. The project page is available at https://dp-recon.github.io/.

  • 7 authors
·
Mar 18, 2025 2

GaMO: Geometry-aware Multi-view Diffusion Outpainting for Sparse-View 3D Reconstruction

Recent advances in 3D reconstruction have achieved remarkable progress in high-quality scene capture from dense multi-view imagery, yet struggle when input views are limited. Various approaches, including regularization techniques, semantic priors, and geometric constraints, have been implemented to address this challenge. Latest diffusion-based methods have demonstrated substantial improvements by generating novel views from new camera poses to augment training data, surpassing earlier regularization and prior-based techniques. Despite this progress, we identify three critical limitations in these state-of-the-art approaches: inadequate coverage beyond known view peripheries, geometric inconsistencies across generated views, and computationally expensive pipelines. We introduce GaMO (Geometry-aware Multi-view Outpainter), a framework that reformulates sparse-view reconstruction through multi-view outpainting. Instead of generating new viewpoints, GaMO expands the field of view from existing camera poses, which inherently preserves geometric consistency while providing broader scene coverage. Our approach employs multi-view conditioning and geometry-aware denoising strategies in a zero-shot manner without training. Extensive experiments on Replica and ScanNet++ demonstrate state-of-the-art reconstruction quality across 3, 6, and 9 input views, outperforming prior methods in PSNR and LPIPS, while achieving a 25times speedup over SOTA diffusion-based methods with processing time under 10 minutes. Project page: https://yichuanh.github.io/GaMO/

  • 5 authors
·
Dec 31, 2025 3

GeoQuery: Geometry-Query Diffusion for Sparse-View Reconstruction

3D Gaussian Splatting (3DGS) has emerged as a prominent paradigm for 3D reconstruction and novel view synthesis. However, it remains vulnerable to severe artifacts when trained under sparse-view constraints. While recent methods attempt to rectify artifacts in rendered views using image diffusion models, they typically rely on multi-view self-attention to retrieve information from reference images. We observe that this mechanism often fails when the rendered novel views output by 3DGS are heavily corrupted: damaged query features lead to erroneous cross-view retrieval, resulting in inconsistent rendering refinement. To address this, we propose GeoQuery, a geometry-guided diffusion framework that integrates generative priors with explicit geometric cues via a novel Geometry-guided Cross-view Attention (GCA) mechanism. First, by leveraging predicted depth maps and camera poses, we construct a geometry-induced correspondence field to sample reference features, forming a geometry-aligned proxy query that replaces the corrupted rendering features. Furthermore, we design a new cross-view feature aggregation pipeline, in which we restrict the cross-view attention to a local window around each proxy query to effectively retrieve useful features while suppressing spurious matches. GeoQuery can be seamlessly integrated into existing diffusion-based pipelines, enabling robust reconstruction even under extreme view sparsity. Extensive experiments on sparse-view novel view synthesis and rendering artifact removal demonstrate the effectiveness of our approach.

  • 7 authors
·
May 11

RED-PSM: Regularization by Denoising of Partially Separable Models for Dynamic Imaging

Dynamic imaging addresses the recovery of a time-varying 2D or 3D object at each time instant using its undersampled measurements. In particular, in the case of dynamic tomography, only a single projection at a single view angle may be available at a time, making the problem severely ill-posed. In this work, we propose an approach, RED-PSM, which combines for the first time two powerful techniques to address this challenging imaging problem. The first, are partially separable models, which have been used to efficiently introduce a low-rank prior for the spatio-temporal object. The second is the recent Regularization by Denoising (RED), which provides a flexible framework to exploit the impressive performance of state-of-the-art image denoising algorithms, for various inverse problems. We propose a partially separable objective with RED and a computationally efficient and scalable optimization scheme with variable splitting and ADMM. Theoretical analysis proves the convergence of our objective to a value corresponding to a stationary point satisfying the first-order optimality conditions. Convergence is accelerated by a particular projection-domain-based initialization. We demonstrate the performance and computational improvements of our proposed RED-PSM with a learned image denoiser by comparing it to a recent deep-prior-based method known as TD-DIP. Although the main focus is on dynamic tomography, we also show the performance advantages of RED-PSM in a cardiac dynamic MRI setting.

  • 3 authors
·
Apr 7, 2023

SparseSSP: 3D Subcellular Structure Prediction from Sparse-View Transmitted Light Images

Traditional fluorescence staining is phototoxic to live cells, slow, and expensive; thus, the subcellular structure prediction (SSP) from transmitted light (TL) images is emerging as a label-free, faster, low-cost alternative. However, existing approaches utilize 3D networks for one-to-one voxel level dense prediction, which necessitates a frequent and time-consuming Z-axis imaging process. Moreover, 3D convolutions inevitably lead to significant computation and GPU memory overhead. Therefore, we propose an efficient framework, SparseSSP, predicting fluorescent intensities within the target voxel grid in an efficient paradigm instead of relying entirely on 3D topologies. In particular, SparseSSP makes two pivotal improvements to prior works. First, SparseSSP introduces a one-to-many voxel mapping paradigm, which permits the sparse TL slices to reconstruct the subcellular structure. Secondly, we propose a hybrid dimensions topology, which folds the Z-axis information into channel features, enabling the 2D network layers to tackle SSP under low computational cost. We conduct extensive experiments to validate the effectiveness and advantages of SparseSSP on diverse sparse imaging ratios, and our approach achieves a leading performance compared to pure 3D topologies. SparseSSP reduces imaging frequencies compared to previous dense-view SSP (i.e., the number of imaging is reduced up to 87.5% at most), which is significant in visualizing rapid biological dynamics on low-cost devices and samples.

  • 6 authors
·
Jul 2, 2024

Text-to-CT Generation via 3D Latent Diffusion Model with Contrastive Vision-Language Pretraining

Objective: While recent advances in text-conditioned generative models have enabled the synthesis of realistic medical images, progress has been largely confined to 2D modalities such as chest X-rays. Extending text-to-image generation to volumetric Computed Tomography (CT) remains a significant challenge, due to its high dimensionality, anatomical complexity, and the absence of robust frameworks that align vision-language data in 3D medical imaging. Methods: We introduce a novel architecture for Text-to-CT generation that combines a latent diffusion model with a 3D contrastive vision-language pretraining scheme. Our approach leverages a dual-encoder CLIP-style model trained on paired CT volumes and radiology reports to establish a shared embedding space, which serves as the conditioning input for generation. CT volumes are compressed into a low-dimensional latent space via a pretrained volumetric VAE, enabling efficient 3D denoising diffusion without requiring external super-resolution stages. Results: We evaluate our method on the CT-RATE dataset and conduct a comprehensive assessment of image fidelity, clinical relevance, and semantic alignment. Our model achieves competitive performance across all tasks, significantly outperforming prior baselines for text-to-CT generation. Moreover, we demonstrate that CT scans synthesized by our framework can effectively augment real data, improving downstream diagnostic performance. Conclusion: Our results show that modality-specific vision-language alignment is a key component for high-quality 3D medical image generation. By integrating contrastive pretraining and volumetric diffusion, our method offers a scalable and controllable solution for synthesizing clinically meaningful CT volumes from text, paving the way for new applications in data augmentation, medical education, and automated clinical simulation.

  • 5 authors
·
May 31, 2025

Quantifying and Alleviating Co-Adaptation in Sparse-View 3D Gaussian Splatting

3D Gaussian Splatting (3DGS) has demonstrated impressive performance in novel view synthesis under dense-view settings. However, in sparse-view scenarios, despite the realistic renderings in training views, 3DGS occasionally manifests appearance artifacts in novel views. This paper investigates the appearance artifacts in sparse-view 3DGS and uncovers a core limitation of current approaches: the optimized Gaussians are overly-entangled with one another to aggressively fit the training views, which leads to a neglect of the real appearance distribution of the underlying scene and results in appearance artifacts in novel views. The analysis is based on a proposed metric, termed Co-Adaptation Score (CA), which quantifies the entanglement among Gaussians, i.e., co-adaptation, by computing the pixel-wise variance across multiple renderings of the same viewpoint, with different random subsets of Gaussians. The analysis reveals that the degree of co-adaptation is naturally alleviated as the number of training views increases. Based on the analysis, we propose two lightweight strategies to explicitly mitigate the co-adaptation in sparse-view 3DGS: (1) random gaussian dropout; (2) multiplicative noise injection to the opacity. Both strategies are designed to be plug-and-play, and their effectiveness is validated across various methods and benchmarks. We hope that our insights into the co-adaptation effect will inspire the community to achieve a more comprehensive understanding of sparse-view 3DGS.

  • 7 authors
·
Sep 19, 2025

RDG-GS: Relative Depth Guidance with Gaussian Splatting for Real-time Sparse-View 3D Rendering

Efficiently synthesizing novel views from sparse inputs while maintaining accuracy remains a critical challenge in 3D reconstruction. While advanced techniques like radiance fields and 3D Gaussian Splatting achieve rendering quality and impressive efficiency with dense view inputs, they suffer from significant geometric reconstruction errors when applied to sparse input views. Moreover, although recent methods leverage monocular depth estimation to enhance geometric learning, their dependence on single-view estimated depth often leads to view inconsistency issues across different viewpoints. Consequently, this reliance on absolute depth can introduce inaccuracies in geometric information, ultimately compromising the quality of scene reconstruction with Gaussian splats. In this paper, we present RDG-GS, a novel sparse-view 3D rendering framework with Relative Depth Guidance based on 3D Gaussian Splatting. The core innovation lies in utilizing relative depth guidance to refine the Gaussian field, steering it towards view-consistent spatial geometric representations, thereby enabling the reconstruction of accurate geometric structures and capturing intricate textures. First, we devise refined depth priors to rectify the coarse estimated depth and insert global and fine-grained scene information to regular Gaussians. Building on this, to address spatial geometric inaccuracies from absolute depth, we propose relative depth guidance by optimizing the similarity between spatially correlated patches of depth and images. Additionally, we also directly deal with the sparse areas challenging to converge by the adaptive sampling for quick densification. Across extensive experiments on Mip-NeRF360, LLFF, DTU, and Blender, RDG-GS demonstrates state-of-the-art rendering quality and efficiency, making a significant advancement for real-world application.

  • 5 authors
·
Jan 19, 2025

Dual-Prior Guided Null-Space Learning with Mixture-of-Splines for Arbitrary Medical Slice Super-Resolution

Arbitrary slice super-resolution reconstructs isotropic volumes from anisotropic clinical acquisitions by synthesizing intermediate slices at arbitrary scales. However, treating this ill-posed inverse problem as unconstrained residual-based regression risks hallucinating anatomically implausible structures or altering the originally observed data. To address both concerns, this paper presents the Dual-Prior Null-space Learning (DP-NSL) framework, which reformulates the task as a constrained recovery process guided by two complementary priors. A Measurement-Consistent Projection (MCP) enforces a Deterministic Observation Prior: the reconstruction undergoes an exact orthogonal projection that reproduces every acquired slice with zero error, confining all learned details to the unobservable null space. Within this null space, a Mixture-of-Splines (MoS) module imposes a Geometric Continuity Prior by dynamically mixing B-spline experts of different analytic orders, allowing each anatomical region to be modeled with a content-aware level of continuity. To promote spatial coherence, a Local Spatial Consistency Decoder (LSCD) further injects local inductive bias. Experiments on three CT and one MRI benchmark show that DP-NSL outperforms existing approaches while strictly preserving measurement consistency. Code is available at https://github.com/DeepMed-Lab-ECNU/Medical-Image-Reconstruction.

  • 6 authors
·
Jun 25

FaVoR: Features via Voxel Rendering for Camera Relocalization

Camera relocalization methods range from dense image alignment to direct camera pose regression from a query image. Among these, sparse feature matching stands out as an efficient, versatile, and generally lightweight approach with numerous applications. However, feature-based methods often struggle with significant viewpoint and appearance changes, leading to matching failures and inaccurate pose estimates. To overcome this limitation, we propose a novel approach that leverages a globally sparse yet locally dense 3D representation of 2D features. By tracking and triangulating landmarks over a sequence of frames, we construct a sparse voxel map optimized to render image patch descriptors observed during tracking. Given an initial pose estimate, we first synthesize descriptors from the voxels using volumetric rendering and then perform feature matching to estimate the camera pose. This methodology enables the generation of descriptors for unseen views, enhancing robustness to view changes. We extensively evaluate our method on the 7-Scenes and Cambridge Landmarks datasets. Our results show that our method significantly outperforms existing state-of-the-art feature representation techniques in indoor environments, achieving up to a 39% improvement in median translation error. Additionally, our approach yields comparable results to other methods for outdoor scenarios while maintaining lower memory and computational costs.

  • 4 authors
·
Sep 11, 2024

OReX: Object Reconstruction from Planar Cross-sections Using Neural Fields

Reconstructing 3D shapes from planar cross-sections is a challenge inspired by downstream applications like medical imaging and geographic informatics. The input is an in/out indicator function fully defined on a sparse collection of planes in space, and the output is an interpolation of the indicator function to the entire volume. Previous works addressing this sparse and ill-posed problem either produce low quality results, or rely on additional priors such as target topology, appearance information, or input normal directions. In this paper, we present OReX, a method for 3D shape reconstruction from slices alone, featuring a Neural Field as the interpolation prior. A modest neural network is trained on the input planes to return an inside/outside estimate for a given 3D coordinate, yielding a powerful prior that induces smoothness and self-similarities. The main challenge for this approach is high-frequency details, as the neural prior is overly smoothing. To alleviate this, we offer an iterative estimation architecture and a hierarchical input sampling scheme that encourage coarse-to-fine training, allowing the training process to focus on high frequencies at later stages. In addition, we identify and analyze a ripple-like effect stemming from the mesh extraction step. We mitigate it by regularizing the spatial gradients of the indicator function around input in/out boundaries during network training, tackling the problem at the root. Through extensive qualitative and quantitative experimentation, we demonstrate our method is robust, accurate, and scales well with the size of the input. We report state-of-the-art results compared to previous approaches and recent potential solutions, and demonstrate the benefit of our individual contributions through analysis and ablation studies.

  • 3 authors
·
Nov 23, 2022

T^2exture: Sparsely Perturbed Thermal-to-Texture Imaging

Thermal imaging remains effective under adverse illumination, yet passive long-wave infrared (LWIR) measurements often lack fine texture. Existing thermal texture imaging approaches commonly rely on spectral sensing or registered auxiliary modalities, incurring substantial data throughput or vulnerability to cross-modal degradation. We introduce T^2exture, a sparsely perturbed thermal texture imaging framework that aims to reconstruct temporally dense thermal texture sequences from densely sampled passive frames and a few actively perturbed keyframes. We define thermal texture as the residual between a source-on observation and its corresponding source-off passive state. Under sparse LWIR illumination and rapid quasi-steady paired acquisition, this residual attenuates the passive-emission background and approximates a source-induced reflected response, exposing localized material- and geometry-dependent texture. T^2exture reconstructs a dense sequence of this source-conditioned response through two stages. Stage 1 estimates the unobserved source-off passive state at each active instant from neighboring passive frames to obtain reliable differential texture anchors. Stage 2 combines sparse anchors with passive structural context near each target time to reconstruct the dense sequence. On the simulated benchmark, T^2exture adds only 0.20M parameters to AMT-L while improving PSNR by 6.66 dB. Extensive evaluations on simulated and real acquisitions further show clearer texture recovery and stronger structural preservation than representative VFI baselines. These results establish T^2exture as a practical framework for thermal texture imaging under sparse active acquisition.

  • 4 authors
·
Aug 2

A Unified Model for Compressed Sensing MRI Across Undersampling Patterns

Compressed Sensing MRI reconstructs images of the body's internal anatomy from undersampled measurements, thereby reducing scan time. Recently, deep learning has shown great potential for reconstructing high-fidelity images from highly undersampled measurements. However, one needs to train multiple models for different undersampling patterns and desired output image resolutions, since most networks operate on a fixed discretization. Such approaches are highly impractical in clinical settings, where undersampling patterns and image resolutions are frequently changed to accommodate different real-time imaging and diagnostic requirements. We propose a unified MRI reconstruction model robust to various measurement undersampling patterns and image resolutions. Our approach uses neural operators, a discretization-agnostic architecture applied in both image and measurement spaces, to capture local and global features. Empirically, our model improves SSIM by 11% and PSNR by 4 dB over a state-of-the-art CNN (End-to-End VarNet), with 600times faster inference than diffusion methods. The resolution-agnostic design also enables zero-shot super-resolution and extended field-of-view reconstruction, offering a versatile and efficient solution for clinical MR imaging. Our unified model offers a versatile solution for MRI, adapting seamlessly to various measurement undersampling and imaging resolutions, making it highly effective for flexible and reliable clinical imaging. Our code is available at https://armeet.ca/nomri.

  • 7 authors
·
Oct 5, 2024 1

Zero-Shot Low-dose CT Denoising via Sinogram Flicking

Many low-dose CT imaging methods rely on supervised learning, which requires a large number of paired noisy and clean images. However, obtaining paired images in clinical practice is challenging. To address this issue, zero-shot self-supervised methods train denoising networks using only the information within a single image, such as ZS-N2N. However, these methods often employ downsampling operations that degrade image resolution. Additionally, the training dataset is inherently constrained to the image itself. In this paper, we propose a zero-shot low-dose CT imaging method based on sinogram flicking, which operates within a single image but generates many copies via random conjugate ray matching. Specifically, two conjugate X-ray pencil beams measure the same path; their expected values should be identical, while their noise levels vary during measurements. By randomly swapping portions of the conjugate X-rays in the sinogram domain, we generate a large set of sinograms with consistent content but varying noise patterns. When displayed dynamically, these sinograms exhibit a flickering effect due to their identical structural content but differing noise patterns-hence the term sinogram flicking. We train the network on pairs of sinograms with the same content but different noise distributions using a lightweight model adapted from ZS-NSN. This process is repeated to obtain the final results. A simulation study demonstrates that our method outperforms state-of-the-art approaches such as ZS-N2N.

  • 2 authors
·
Apr 10, 2025

Parameter-Efficient Adaptation of SAM 3 for Automated ITV Generation from 4DCT Images

Four-dimensional computed tomography (4DCT) captures the full respiratory cycle of thoracic anatomy, yet current Internal Target Volume contouring workflows process each phase in isolation, discarding temporal coherence and leaving contours vulnerable to phase-specific artifacts. We present a lightweight framework that applies parameter-efficient fine-tuning to the Segment Anything Model 3 (SAM 3) via low-rank adaptation (LoRA) to align its text-prompted segmentation with the medical domain using only seven annotated 3D CT volumes. Furthermore, the framework incorporates a hard negative mining strategy to improve boundary discrimination in low-contrast thoracic regions. At inference, phase-wise predictions are refined through phase-coherent temporal filtering and spatial connectivity analysis. Since respiratory motion is continuous and periodic, genuine anatomy appears in contiguous blocks of phases, whereas transient artifacts appear sporadically and are thus effectively suppressed. Experiments on pulmonary and cardiac structures yield median Dice scores of 0.968 and 0.910 with 95th-percentile Hausdorff distances of 0.998 mm and 2.931 mm, respectively. The proposed framework effectively eliminates the severe false-positive predictions inherent in the zero-shot inference of the unadapted SAM 3. With only seven annotated volumes, the framework retains over 95% of full-data accuracy, and the entire pipeline is trainable on a single consumer-grade GPU, demonstrating a scalable, data-efficient solution for adaptive radiotherapy.

  • 1 authors
·
Jun 13

Anatomy-Decomposed Chest Computed Tomography (CT) Projections as Scalable Supervision for Bone Suppression in Chest Radiographs

Bone overlap can obscure abnormalities in chest radiographs, while scarce paired training data limit supervised bone suppression. We address this challenge with a digitally reconstructed radiograph (DRR) framework that converts chest computed tomography (CT) into paired supervision for component suppression. A novel bone segmentation algorithm enables CT decomposition into bone, non-lung soft-tissue, and lung components, which are projected separately. Their weighted combination yields synthetic radiographs with pixel-registered component images that sum exactly to the full DRR. Models trained on these data suppress bone or lung components by predicting the target component and recovering the remainder by subtraction, transferring to real radiographs without real paired training data. As an extension, their outputs on real radiographs provide target domains for unpaired, component-wise DRR translation, reducing the appearance gap while retaining anatomical details. Across multiple public datasets, downstream detection experiments demonstrate the utility of bone suppression, with gains concentrated on abnormalities with substantial bone overlap. Compared with open-source DRR engines applied to the same CTs, our unmodified DRRs achieve comparable realism and preservation of label-relevant anatomy, while translated DRRs achieve the best Fréchet inception distance (FID), lung-field sharpness, and agreement with source-CT anatomy among the evaluated methods. Models and inference code: https://huggingface.co/qureaiorg/bone-suppression; Translated projections: https://huggingface.co/datasets/qureaiorg/ct2xr-projections.

  • 7 authors
·
Sep 20

A Quantitative Evaluation of Dense 3D Reconstruction of Sinus Anatomy from Monocular Endoscopic Video

Generating accurate 3D reconstructions from endoscopic video is a promising avenue for longitudinal radiation-free analysis of sinus anatomy and surgical outcomes. Several methods for monocular reconstruction have been proposed, yielding visually pleasant 3D anatomical structures by retrieving relative camera poses with structure-from-motion-type algorithms and fusion of monocular depth estimates. However, due to the complex properties of the underlying algorithms and endoscopic scenes, the reconstruction pipeline may perform poorly or fail unexpectedly. Further, acquiring medical data conveys additional challenges, presenting difficulties in quantitatively benchmarking these models, understanding failure cases, and identifying critical components that contribute to their precision. In this work, we perform a quantitative analysis of a self-supervised approach for sinus reconstruction using endoscopic sequences paired with optical tracking and high-resolution computed tomography acquired from nine ex-vivo specimens. Our results show that the generated reconstructions are in high agreement with the anatomy, yielding an average point-to-mesh error of 0.91 mm between reconstructions and CT segmentations. However, in a point-to-point matching scenario, relevant for endoscope tracking and navigation, we found average target registration errors of 6.58 mm. We identified that pose and depth estimation inaccuracies contribute equally to this error and that locally consistent sequences with shorter trajectories generate more accurate reconstructions. These results suggest that achieving global consistency between relative camera poses and estimated depths with the anatomy is essential. In doing so, we can ensure proper synergy between all components of the pipeline for improved reconstructions that will facilitate clinical application of this innovative technology.

  • 12 authors
·
Oct 22, 2023

GenerateCT: Text-Guided 3D Chest CT Generation

Generative modeling has experienced substantial progress in recent years, particularly in text-to-image and text-to-video synthesis. However, the medical field has not yet fully exploited the potential of large-scale foundational models for synthetic data generation. In this paper, we introduce GenerateCT, the first method for text-conditional computed tomography (CT) generation, addressing the limitations in 3D medical imaging research and making our entire framework open-source. GenerateCT consists of a pre-trained large language model, a transformer-based text-conditional 3D chest CT generation architecture, and a text-conditional spatial super-resolution diffusion model. We also propose CT-ViT, which efficiently compresses CT volumes while preserving auto-regressiveness in-depth, enabling the generation of 3D CT volumes with variable numbers of axial slices. Our experiments demonstrate that GenerateCT can produce realistic, high-resolution, and high-fidelity 3D chest CT volumes consistent with medical language text prompts. We further investigate the potential of GenerateCT by training a model using generated CT volumes for multi-abnormality classification of chest CT volumes. Our contributions provide a valuable foundation for future research in text-conditional 3D medical image generation and have the potential to accelerate advancements in medical imaging research. Our code, pre-trained models, and generated data are available at https://github.com/ibrahimethemhamamci/GenerateCT.

  • 11 authors
·
May 25, 2023

Snap-Snap: Taking Two Images to Reconstruct 3D Human Gaussians in Milliseconds

Reconstructing 3D human bodies from sparse views has been an appealing topic, which is crucial to broader the related applications. In this paper, we propose a quite challenging but valuable task to reconstruct the human body from only two images, i.e., the front and back view, which can largely lower the barrier for users to create their own 3D digital humans. The main challenges lie in the difficulty of building 3D consistency and recovering missing information from the highly sparse input. We redesign a geometry reconstruction model based on foundation reconstruction models to predict consistent point clouds even input images have scarce overlaps with extensive human data training. Furthermore, an enhancement algorithm is applied to supplement the missing color information, and then the complete human point clouds with colors can be obtained, which are directly transformed into 3D Gaussians for better rendering quality. Experiments show that our method can reconstruct the entire human in 190 ms on a single NVIDIA RTX 4090, with two images at a resolution of 1024x1024, demonstrating state-of-the-art performance on the THuman2.0 and cross-domain datasets. Additionally, our method can complete human reconstruction even with images captured by low-cost mobile devices, reducing the requirements for data collection. Demos and code are available at https://hustvl.github.io/Snap-Snap/.

  • 9 authors
·
Aug 20, 2025 2

DMCVR: Morphology-Guided Diffusion Model for 3D Cardiac Volume Reconstruction

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology used in clinical settings is 2D with limited through-plane resolution, resulting in low-quality reconstructed cardiac volumes. To better reconstruct 3D cardiac volumes from sparse 2D image stacks, we propose a morphology-guided diffusion model for 3D cardiac volume reconstruction, DMCVR, that synthesizes high-resolution 2D images and corresponding 3D reconstructed volumes. Our method outperforms previous approaches by conditioning the cardiac morphology on the generative model, eliminating the time-consuming iterative optimization process of the latent code, and improving generation quality. The learned latent spaces provide global semantics, local cardiac morphology and details of each 2D cMRI slice with highly interpretable value to reconstruct 3D cardiac shape. Our experiments show that DMCVR is highly effective in several aspects, such as 2D generation and 3D reconstruction performance. With DMCVR, we can produce high-resolution 3D cardiac MRI reconstructions, surpassing current techniques. Our proposed framework has great potential for improving the accuracy of cardiac disease diagnosis and treatment planning. Code can be accessed at https://github.com/hexiaoxiao-cs/DMCVR.

  • 7 authors
·
Aug 17, 2023

DensiTok: Making Feed-Forward 3D Gaussian Splatting See More Views Than It Is Given

Feed-forward 3D Gaussian Splatting (3DGS) reconstructs a scene in a single forward pass, replacing per-scene optimization with a network trained across many scenes. Its quality, however, degrades sharply as the number of input images drops. The bottleneck is upstream of the reconstruction heads: from a few unposed views, the internal representation they read carries no evidence for unobserved regions, leaving holes, floaters, and blur. The common remedy supplies that evidence as pixels, synthesizing extra views with an image or video generator and re-encoding them, which is costly and not 3D-consistent by construction. We instead densify the evidence itself. We present DensiTok, a plug-in module for pretrained feed-forward 3DGS models that densifies their internal geometry tokens directly, making a frozen backbone behave as though it had observed many more views than it was given. DensiTok compresses those tokens into a compact latent space, completes the latents of the unobserved viewpoints in a single flow-matching step conditioned on camera geometry, and decodes them back into tokens that the original reconstruction heads. The same module design can be integrated into different pretrained predictors while keeping each backbone and its reconstruction heads frozen. Completion in a low-dimensional latent space requires no image synthesis or additional encoder passes. Across three pretrained backbones and two benchmarks, DensiTok consistently improves sparse-view reconstruction and recovers much of the gap to dense-view reconstruction.

  • 6 authors
·
Oct 5

Learning Sub-Sampling and Signal Recovery with Applications in Ultrasound Imaging

Limitations on bandwidth and power consumption impose strict bounds on data rates of diagnostic imaging systems. Consequently, the design of suitable (i.e. task- and data-aware) compression and reconstruction techniques has attracted considerable attention in recent years. Compressed sensing emerged as a popular framework for sparse signal reconstruction from a small set of compressed measurements. However, typical compressed sensing designs measure a (non)linearly weighted combination of all input signal elements, which poses practical challenges. These designs are also not necessarily task-optimal. In addition, real-time recovery is hampered by the iterative and time-consuming nature of sparse recovery algorithms. Recently, deep learning methods have shown promise for fast recovery from compressed measurements, but the design of adequate and practical sensing strategies remains a challenge. Here, we propose a deep learning solution termed Deep Probabilistic Sub-sampling (DPS), that learns a task-driven sub-sampling pattern, while jointly training a subsequent task model. Once learned, the task-based sub-sampling patterns are fixed and straightforwardly implementable, e.g. by non-uniform analog-to-digital conversion, sparse array design, or slow-time ultrasound pulsing schemes. The effectiveness of our framework is demonstrated in-silico for sparse signal recovery from partial Fourier measurements, and in-vivo for both anatomical image and tissue-motion (Doppler) reconstruction from sub-sampled medical ultrasound imaging data.

  • 5 authors
·
Aug 15, 2019

GL-LCM: Global-Local Latent Consistency Models for Fast High-Resolution Bone Suppression in Chest X-Ray Images

Chest X-Ray (CXR) imaging for pulmonary diagnosis raises significant challenges, primarily because bone structures can obscure critical details necessary for accurate diagnosis. Recent advances in deep learning, particularly with diffusion models, offer significant promise for effectively minimizing the visibility of bone structures in CXR images, thereby improving clarity and diagnostic accuracy. Nevertheless, existing diffusion-based methods for bone suppression in CXR imaging struggle to balance the complete suppression of bones with preserving local texture details. Additionally, their high computational demand and extended processing time hinder their practical use in clinical settings. To address these limitations, we introduce a Global-Local Latent Consistency Model (GL-LCM) architecture. This model combines lung segmentation, dual-path sampling, and global-local fusion, enabling fast high-resolution bone suppression in CXR images. To tackle potential boundary artifacts and detail blurring in local-path sampling, we further propose Local-Enhanced Guidance, which addresses these issues without additional training. Comprehensive experiments on a self-collected dataset SZCH-X-Rays, and the public dataset JSRT, reveal that our GL-LCM delivers superior bone suppression and remarkable computational efficiency, significantly outperforming several competitive methods. Our code is available at https://github.com/diaoquesang/GL-LCM.

  • 10 authors
·
Aug 5, 2025

GeoSVR: Taming Sparse Voxels for Geometrically Accurate Surface Reconstruction

Reconstructing accurate surfaces with radiance fields has achieved remarkable progress in recent years. However, prevailing approaches, primarily based on Gaussian Splatting, are increasingly constrained by representational bottlenecks. In this paper, we introduce GeoSVR, an explicit voxel-based framework that explores and extends the under-investigated potential of sparse voxels for achieving accurate, detailed, and complete surface reconstruction. As strengths, sparse voxels support preserving the coverage completeness and geometric clarity, while corresponding challenges also arise from absent scene constraints and locality in surface refinement. To ensure correct scene convergence, we first propose a Voxel-Uncertainty Depth Constraint that maximizes the effect of monocular depth cues while presenting a voxel-oriented uncertainty to avoid quality degradation, enabling effective and robust scene constraints yet preserving highly accurate geometries. Subsequently, Sparse Voxel Surface Regularization is designed to enhance geometric consistency for tiny voxels and facilitate the voxel-based formation of sharp and accurate surfaces. Extensive experiments demonstrate our superior performance compared to existing methods across diverse challenging scenarios, excelling in geometric accuracy, detail preservation, and reconstruction completeness while maintaining high efficiency. Code is available at https://github.com/Fictionarry/GeoSVR.

  • 7 authors
·
Sep 22, 2025 2

MedGSSR: Generalizable Medical Image Super-Resolution 3D Reconstruction via Hierarchical Feed-forward Gaussian Splatting

High-resolution volumetric medical imaging is critical for clinical diagnosis, yet acquisition is often limited by scanner hardware, scan time, and for CT, radiation dose. Medical 3D Super-Resolution (Med3DSR) offers a computational alternative, but existing methods commonly rely on per-subject optimization, pretrained priors, or coordinate-based implicit representations, which compromise anatomical fidelity and limit efficiency. To address these limitations, we present MedGSSR, a fully end-to-end feed-forward framework that represents volumes as an explicit 3D Gaussian field for Med3DSR. Unlike coordinate-based implicit functions, our explicit 3D Gaussian representation naturally enhances signal continuity and local high-frequency fidelity. Specifically, MedGSSR explicitly decouples the reconstruction process into coarse-grained structural preservation and fine-grained textural refinement through the proposed Pyramid Anatomical Encoder and a Hierarchical Gaussian Projector. To support arbitrary-scale super-resolution, we introduce sub-voxel Gaussian decomposition and a Differentiable Gaussian Voxelizer that directly queries the continuous 3D intensity field, reducing discretization artifacts. Extensive experiments on MRI and CT benchmarks demonstrate that MedGSSR significantly outperforms state-of-the-art methods. Notably, our framework exhibits robust generalizability across unseen datasets without requiring per-subject optimization, enabling fast inference and high-fidelity volumetric super-resolution in practical clinical settings. Our project webpage, including code, is at https://william2ai.github.io/medgssr

  • 10 authors
·
Sep 5

Latent Interpolation Learning Using Diffusion Models for Cardiac Volume Reconstruction

Cardiac Magnetic Resonance (CMR) imaging is a critical tool for diagnosing and managing cardiovascular disease, yet its utility is often limited by the sparse acquisition of 2D short-axis slices, resulting in incomplete volumetric information. Accurate 3D reconstruction from these sparse slices is essential for comprehensive cardiac assessment, but existing methods face challenges, including reliance on predefined interpolation schemes (e.g., linear or spherical), computational inefficiency, and dependence on additional semantic inputs such as segmentation labels or motion data. To address these limitations, we propose a novel Cardiac Latent Interpolation Diffusion (CaLID) framework that introduces three key innovations. First, we present a data-driven interpolation scheme based on diffusion models, which can capture complex, non-linear relationships between sparse slices and improves reconstruction accuracy. Second, we design a computationally efficient method that operates in the latent space and speeds up 3D whole-heart upsampling time by a factor of 24, reducing computational overhead compared to previous methods. Third, with only sparse 2D CMR images as input, our method achieves SOTA performance against baseline methods, eliminating the need for auxiliary input such as morphological guidance, thus simplifying workflows. We further extend our method to 2D+T data, enabling the effective modeling of spatiotemporal dynamics and ensuring temporal coherence. Extensive volumetric evaluations and downstream segmentation tasks demonstrate that CaLID achieves superior reconstruction quality and efficiency. By addressing the fundamental limitations of existing approaches, our framework advances the state of the art for spatio and spatiotemporal whole-heart reconstruction, offering a robust and clinically practical solution for cardiovascular imaging.

  • 11 authors
·
Aug 19, 2025