Daily Papers

Traditional robotic hand metrics focus on static properties such as workspace, manipulability, and grasp stability. However, these metrics do not directly measure dexterity under the standard definition in robotic manipulation: the ability to continuously change an object's pose within the hand while maintaining contact from an initial grasp. We introduce Kinematic Rolling Manipulation Ability (KaRMA), a kinematic-only metric for fine manipulation that quantifies reachable in-hand translation and reorientation of a spherical test object within a two-finger precision pinch through feasible rolling motions. KaRMA enforces joint limits, collision constraints, rolling contact, and antipodal force feasibility, then investigates reachable in-hand object poses via breadth-first search over translation and rotation primitives. KaRMA reports three scores: translational coverage (KaRMA-T), rotational coverage (KaRMA-R), and sensitivity to the initial grasp (KaRMA-S). We evaluate KaRMA on 16 widely used robotic hands and compare against static baselines, showing that KaRMA separates hands that rank identically under static proxies, reveals translation-rotation tradeoffs invisible to existing baselines, and is qualitatively consistent with selected published task benchmarks where Jacobian-based metrics can be misleading.

Non-Autoregressive Neural Machine Translation (NAT) has achieved significant inference speedup by generating all tokens simultaneously. Despite its high efficiency, NAT usually suffers from two kinds of translation errors: over-translation (e.g. repeated tokens) and under-translation (e.g. missing translations), which eventually limits the translation quality. In this paper, we argue that these issues of NAT can be addressed through coverage modeling, which has been proved to be useful in autoregressive decoding. We propose a novel Coverage-NAT to model the coverage information directly by a token-level coverage iterative refinement mechanism and a sentence-level coverage agreement, which can remind the model if a source token has been translated or not and improve the semantics consistency between the translation and the source, respectively. Experimental results on WMT14 En-De and WMT16 En-Ro translation tasks show that our method can alleviate those errors and achieve strong improvements over the baseline system.

Large language models, particularly GPT-3, are able to produce high quality summaries of general domain news articles in few- and zero-shot settings. However, it is unclear if such models are similarly capable in more specialized, high-stakes domains such as biomedicine. In this paper, we enlist domain experts (individuals with medical training) to evaluate summaries of biomedical articles generated by GPT-3, given zero supervision. We consider both single- and multi-document settings. In the former, GPT-3 is tasked with generating regular and plain-language summaries of articles describing randomized controlled trials; in the latter, we assess the degree to which GPT-3 is able to synthesize evidence reported across a collection of articles. We design an annotation scheme for evaluating model outputs, with an emphasis on assessing the factual accuracy of generated summaries. We find that while GPT-3 is able to summarize and simplify single biomedical articles faithfully, it struggles to provide accurate aggregations of findings over multiple documents. We release all data and annotations used in this work.

Large language models (LLMs) have grown in their usage to provide support for question answering across numerous disciplines. The models on their own have already shown promise for answering basic questions, however fail quickly where expert domain knowledge is required or the question is nuanced. Scientific research often involves searching for relevant literature, distilling pertinent information from that literature and analysing how the findings support or contradict one another. The information is often encapsulated in the full text body of research articles, rather than just in the abstracts. Statements within these articles frequently require the wider article context to be fully understood. We have built an LLM-based system that performs such search and distillation of information encapsulated in scientific literature, and we evaluate our keyword based search and information distillation system against a set of biology related questions from previously released literature benchmarks. We demonstrate sparse retrieval methods exhibit results close to state of the art without the need for dense retrieval, with its associated infrastructure and complexity overhead. We also show how to increase the coverage of relevant documents for literature review generation.

Machine translation is indispensable in healthcare for enabling the global dissemination of medical knowledge across languages. However, complex medical terminology poses unique challenges to achieving adequate translation quality and accuracy. This study introduces a novel "LLMs-in-the-loop" approach to develop supervised neural machine translation models optimized specifically for medical texts. While large language models (LLMs) have demonstrated powerful capabilities, this research shows that small, specialized models trained on high-quality in-domain (mostly synthetic) data can outperform even vastly larger LLMs. Custom parallel corpora in six languages were compiled from scientific articles, synthetically generated clinical documents, and medical texts. Our LLMs-in-the-loop methodology employs synthetic data generation, rigorous evaluation, and agent orchestration to enhance performance. We developed small medical translation models using the MarianMT base model. We introduce a new medical translation test dataset to standardize evaluation in this domain. Assessed using BLEU, METEOR, ROUGE, and BERT scores on this test set, our MarianMT-based models outperform Google Translate, DeepL, and GPT-4-Turbo. Results demonstrate that our LLMs-in-the-loop approach, combined with fine-tuning high-quality, domain-specific data, enables specialized models to outperform general-purpose and some larger systems. This research, part of a broader series on expert small models, paves the way for future healthcare-related AI developments, including deidentification and bio-medical entity extraction models. Our study underscores the potential of tailored neural translation models and the LLMs-in-the-loop methodology to advance the field through improved data generation, evaluation, agent, and modeling techniques.

Trustworthy Large Language Models (LLMs) must cite human-verifiable sources in high-stakes domains such as healthcare, law, academia, and finance, where even small errors can have severe consequences. Practitioners and researchers face a choice: let models generate citations during decoding, or let models draft answers first and then attach appropriate citations. To clarify this choice, we introduce two paradigms: Generation-Time Citation (G-Cite), which produces the answer and citations in one pass, and Post-hoc Citation (P-Cite), which adds or verifies citations after drafting. We conduct a comprehensive evaluation from zero-shot to advanced retrieval-augmented methods across four popular attribution datasets and provide evidence-based recommendations that weigh trade-offs across use cases. Our results show a consistent trade-off between coverage and citation correctness, with retrieval as the main driver of attribution quality in both paradigms. P-Cite methods achieve high coverage with competitive correctness and moderate latency, whereas G-Cite methods prioritize precision at the cost of coverage and speed. We recommend a retrieval-centric, P-Cite-first approach for high-stakes applications, reserving G-Cite for precision-critical settings such as strict claim verification. Our codes and human evaluation results are available at https://anonymous.4open.science/r/Citation_Paradigms-BBB5/

Foundation models (FMs) have exhibited remarkable performance across a wide range of downstream tasks in many domains. Nevertheless, general-purpose FMs often face challenges when confronted with domain-specific problems, due to their limited access to the proprietary training data in a particular domain. In biomedicine, there are various biological modalities, such as molecules, proteins, and cells, which are encoded by the language of life and exhibit significant modality gaps with human natural language. In this paper, we introduce BioMedGPT, an open multimodal generative pre-trained transformer (GPT) for biomedicine, to bridge the gap between the language of life and human natural language. BioMedGPT allows users to easily ``communicate'' with diverse biological modalities through free text, which is the first of its kind. BioMedGPT aligns different biological modalities with natural language via a large generative language model, namely, BioMedGPT-LM. We publish BioMedGPT-10B, which unifies the feature spaces of molecules, proteins, and natural language via encoding and alignment. Through fine-tuning, BioMedGPT-10B outperforms or is on par with human and significantly larger general-purpose foundation models on the biomedical QA task. It also demonstrates promising performance in the molecule QA and protein QA tasks, which could greatly accelerate the discovery of new drugs and therapeutic targets. In addition, BioMedGPT-LM-7B is the first large generative language model based on Llama2 in the biomedical domain, therefore is commercial friendly. Both BioMedGPT-10B and BioMedGPT-LM-7B are open-sourced to the research community. In addition, we publish the datasets that are meticulously curated for the alignment of multi-modalities, i.e., PubChemQA and UniProtQA. All the models, codes, and datasets are available at https://github.com/PharMolix/OpenBioMed.

This paper describes the development of a new benchmark for machine translation that provides training and test data for thousands of language pairs covering over 500 languages and tools for creating state-of-the-art translation models from that collection. The main goal is to trigger the development of open translation tools and models with a much broader coverage of the World's languages. Using the package it is possible to work on realistic low-resource scenarios avoiding artificially reduced setups that are common when demonstrating zero-shot or few-shot learning. For the first time, this package provides a comprehensive collection of diverse data sets in hundreds of languages with systematic language and script annotation and data splits to extend the narrow coverage of existing benchmarks. Together with the data release, we also provide a growing number of pre-trained baseline models for individual language pairs and selected language groups.

Pre-trained language models have attracted increasing attention in the biomedical domain, inspired by their great success in the general natural language domain. Among the two main branches of pre-trained language models in the general language domain, i.e., BERT (and its variants) and GPT (and its variants), the first one has been extensively studied in the biomedical domain, such as BioBERT and PubMedBERT. While they have achieved great success on a variety of discriminative downstream biomedical tasks, the lack of generation ability constrains their application scope. In this paper, we propose BioGPT, a domain-specific generative Transformer language model pre-trained on large scale biomedical literature. We evaluate BioGPT on six biomedical NLP tasks and demonstrate that our model outperforms previous models on most tasks. Especially, we get 44.98%, 38.42% and 40.76% F1 score on BC5CDR, KD-DTI and DDI end-to-end relation extraction tasks respectively, and 78.2% accuracy on PubMedQA, creating a new record. Our larger model BioGPT-Large achieves 81.0% on PubMedQA. Our case study on text generation further demonstrates the advantage of BioGPT on biomedical literature to generate fluent descriptions for biomedical terms. Code is available at https://github.com/microsoft/BioGPT.

We present FRMT, a new dataset and evaluation benchmark for Few-shot Region-aware Machine Translation, a type of style-targeted translation. The dataset consists of professional translations from English into two regional variants each of Portuguese and Mandarin Chinese. Source documents are selected to enable detailed analysis of phenomena of interest, including lexically distinct terms and distractor terms. We explore automatic evaluation metrics for FRMT and validate their correlation with expert human evaluation across both region-matched and mismatched rating scenarios. Finally, we present a number of baseline models for this task, and offer guidelines for how researchers can train, evaluate, and compare their own models. Our dataset and evaluation code are publicly available: https://bit.ly/frmt-task

In the era of digital healthcare, the huge volumes of textual information generated every day in hospitals constitute an essential but underused asset that could be exploited with task-specific, fine-tuned biomedical language representation models, improving patient care and management. For such specialized domains, previous research has shown that fine-tuning models stemming from broad-coverage checkpoints can largely benefit additional training rounds over large-scale in-domain resources. However, these resources are often unreachable for less-resourced languages like Italian, preventing local medical institutions to employ in-domain adaptation. In order to reduce this gap, our work investigates two accessible approaches to derive biomedical language models in languages other than English, taking Italian as a concrete use-case: one based on neural machine translation of English resources, favoring quantity over quality; the other based on a high-grade, narrow-scoped corpus natively written in Italian, thus preferring quality over quantity. Our study shows that data quantity is a harder constraint than data quality for biomedical adaptation, but the concatenation of high-quality data can improve model performance even when dealing with relatively size-limited corpora. The models published from our investigations have the potential to unlock important research opportunities for Italian hospitals and academia. Finally, the set of lessons learned from the study constitutes valuable insights towards a solution to build biomedical language models that are generalizable to other less-resourced languages and different domain settings.

We present a corpus of 5,000 richly annotated abstracts of medical articles describing clinical randomized controlled trials. Annotations include demarcations of text spans that describe the Patient population enrolled, the Interventions studied and to what they were Compared, and the Outcomes measured (the `PICO' elements). These spans are further annotated at a more granular level, e.g., individual interventions within them are marked and mapped onto a structured medical vocabulary. We acquired annotations from a diverse set of workers with varying levels of expertise and cost. We describe our data collection process and the corpus itself in detail. We then outline a set of challenging NLP tasks that would aid searching of the medical literature and the practice of evidence-based medicine.

Machine translation (MT) in the medical domain plays a pivotal role in enhancing healthcare quality and disseminating medical knowledge. Despite advancements in English-Thai MT technology, common MT approaches often underperform in the medical field due to their inability to precisely translate medical terminologies. Our research prioritizes not merely improving translation accuracy but also maintaining medical terminology in English within the translated text through code-switched (CS) translation. We developed a method to produce CS medical translation data, fine-tuned a CS translation model with this data, and evaluated its performance against strong baselines, such as Google Neural Machine Translation (NMT) and GPT-3.5/GPT-4. Our model demonstrated competitive performance in automatic metrics and was highly favored in human preference evaluations. Our evaluation result also shows that medical professionals significantly prefer CS translations that maintain critical English terms accurately, even if it slightly compromises fluency. Our code and test set are publicly available https://github.com/preceptorai-org/NLLB_CS_EM_NLP2024.

Leading vision-language models (VLMs) are trained on general Internet content, overlooking scientific journals' rich, domain-specific knowledge. Training on specialty-specific literature could yield high-performance, task-specific tools, enabling generative AI to match generalist models in specialty publishing, educational, and clinical tasks. We created NeuroPubs, a multimodal dataset of 23,000 Neurosurgery Publications articles (134M words, 78K image-caption pairs). Using NeuroPubs, VLMs generated publication-ready graphical abstracts (70% of 100 abstracts) and board-style questions indistinguishable from human-written ones (54% of 89,587 questions). We used these questions to train CNS-Obsidian, a 34B-parameter VLM. In a blinded, randomized controlled trial, our model demonstrated non-inferiority to then state-of-the-art GPT-4o in neurosurgical differential diagnosis (clinical utility, 40.62% upvotes vs. 57.89%, p=0.1150; accuracy, 59.38% vs. 65.79%, p=0.3797). Our pilot study demonstrates how training generative AI models on specialty-specific journal content - without large-scale internet data - results in high-performance academic and clinical tools, enabling domain-tailored AI across diverse fields.

Large language models have significantly advanced Multilingual Machine Translation (MMT), yet the broad language coverage, consistent translation quality, and English-centric bias remain open challenges. To address these challenges, we introduce LMT, a suite of Large-scale Multilingual Translation models centered on both Chinese and English, covering 60 languages and 234 translation directions. During development, we identify a previously overlooked phenomenon of directional degeneration, where symmetric multi-way fine-tuning data overemphasize reverse directions (X to En/Zh), leading to excessive many-to-one mappings and degraded translation quality. We propose Strategic Downsampling, a simple yet effective method to mitigate this degeneration. In addition, we design Parallel Multilingual Prompting (PMP), which leverages typologically related auxiliary languages to enhance cross-lingual transfer. Through rigorous data curation and refined adaptation strategies, LMT achieves SOTA performance among models of comparable language coverage, with our 4B model (LMT-60-4B) surpassing the much larger Aya-101-13B and NLLB-54B models by a substantial margin. We release LMT in four sizes (0.6B/1.7B/4B/8B) to catalyze future research and provide strong baselines for inclusive, scalable, and high-quality MMT \href{https://github.com/NiuTrans/LMT{https://github.com/NiuTrans/LMT}}.

Benchmarks of the multilingual capabilities of text-to-image (T2I) models compare generated images prompted in a test language to an expected image distribution over a concept set. One such benchmark, "Conceptual Coverage Across Languages" (CoCo-CroLa), assesses the tangible noun inventory of T2I models by prompting them to generate pictures from a concept list translated to seven languages and comparing the output image populations. Unfortunately, we find that this benchmark contains translation errors of varying severity in Spanish, Japanese, and Chinese. We provide corrections for these errors and analyze how impactful they are on the utility and validity of CoCo-CroLa as a benchmark. We reassess multiple baseline T2I models with the revisions, compare the outputs elicited under the new translations to those conditioned on the old, and show that a correction's impactfulness on the image-domain benchmark results can be predicted in the text domain with similarity scores. Our findings will guide the future development of T2I multilinguality metrics by providing analytical tools for practical translation decisions.

This paper presents a new approach for assessing uncertainty in machine translation by simultaneously evaluating translation quality and providing a reliable confidence score. Our approach utilizes conformal predictive distributions to produce prediction intervals with guaranteed coverage, meaning that for any given significance level epsilon, we can expect the true quality score of a translation to fall out of the interval at a rate of 1-epsilon. In this paper, we demonstrate how our method outperforms a simple, but effective baseline on six different language pairs in terms of coverage and sharpness. Furthermore, we validate that our approach requires the data exchangeability assumption to hold for optimal performance.

Generation capabilities and language coverage of multilingual large language models (mLLMs) are advancing rapidly. However, evaluation practices for generative abilities of mLLMs are still lacking comprehensiveness, scientific rigor, and consistent adoption across research labs, which undermines their potential to meaningfully guide mLLM development. We draw parallels with machine translation (MT) evaluation, a field that faced similar challenges and has, over decades, developed transparent reporting standards and reliable evaluations for multilingual generative models. Through targeted experiments across key stages of the generative evaluation pipeline, we demonstrate how best practices from MT evaluation can deepen the understanding of quality differences between models. Additionally, we identify essential components for robust meta-evaluation of mLLMs, ensuring the evaluation methods themselves are rigorously assessed. We distill these insights into a checklist of actionable recommendations for mLLM research and development.

Medical systematic reviews can be very costly and resource intensive. We explore how Large Language Models (LLMs) can support and be trained to perform literature screening when provided with a detailed set of selection criteria. Specifically, we instruction tune LLaMA and Guanaco models to perform abstract screening for medical systematic reviews. Our best model, Bio-SIEVE, outperforms both ChatGPT and trained traditional approaches, and generalises better across medical domains. However, there remains the challenge of adapting the model to safety-first scenarios. We also explore the impact of multi-task training with Bio-SIEVE-Multi, including tasks such as PICO extraction and exclusion reasoning, but find that it is unable to match single-task Bio-SIEVE's performance. We see Bio-SIEVE as an important step towards specialising LLMs for the biomedical systematic review process and explore its future developmental opportunities. We release our models, code and a list of DOIs to reconstruct our dataset for reproducibility.

Keeping track of scientific challenges, advances and emerging directions is a fundamental part of research. However, researchers face a flood of papers that hinders discovery of important knowledge. In biomedicine, this directly impacts human lives. To address this problem, we present a novel task of extraction and search of scientific challenges and directions, to facilitate rapid knowledge discovery. We construct and release an expert-annotated corpus of texts sampled from full-length papers, labeled with novel semantic categories that generalize across many types of challenges and directions. We focus on a large corpus of interdisciplinary work relating to the COVID-19 pandemic, ranging from biomedicine to areas such as AI and economics. We apply a model trained on our data to identify challenges and directions across the corpus and build a dedicated search engine. In experiments with 19 researchers and clinicians using our system, we outperform a popular scientific search engine in assisting knowledge discovery. Finally, we show that models trained on our resource generalize to the wider biomedical domain and to AI papers, highlighting its broad utility. We make our data, model and search engine publicly available. https://challenges.apps.allenai.org/

We introduce Biomed-Enriched, a biomedical text dataset constructed from PubMed via a two-stage annotation process. In the first stage, a large language model annotates 400K paragraphs from PubMed scientific articles, assigning scores for their type (review, study, clinical case, other), domain (clinical, biomedical, other), and educational quality. The educational quality score (rated 1 to 5) estimates how useful a paragraph is for college-level learning. These annotations are then used to fine-tune a small language model, which propagates the labels across the full PMC-OA corpus. The resulting metadata allows us to extract refined subsets, including 2M clinical case paragraphs with over 450K high-quality ones from articles with commercial-use licenses, and to construct several variants via quality filtering and domain upsampling. Clinical text is typically difficult to access due to privacy constraints, as hospital records cannot be publicly shared. Hence, our dataset provides an alternative large-scale, openly available collection of clinical cases from PubMed, making it a valuable resource for biomedical and clinical NLP. Preliminary continual-pretraining experiments with OLMo2 suggest these curated subsets enable targeted improvements, with clinical upsampling boosting performance by ~5% on MMLU ProfMed and educational quality filtering improving MedQA and MedMCQA by ~1%. Combinations of these techniques led to faster convergence, reaching same performance with a third of training tokens, indicating potential for more efficient and effective biomedical pretraining strategies.

Data science agents promise to accelerate discovery and insight-generation by turning data into executable analyses and findings. Yet existing data science benchmarks fall short due to fragmented evaluation interfaces that make cross-benchmark comparison difficult, narrow task coverage and a lack of rigorous data grounding. In particular, we show that a substantial portion of tasks in current benchmarks can be solved without using the actual data. To address these limitations, we introduce DSGym, a standardized framework for evaluating and training data science agents in self-contained execution environments. Unlike static benchmarks, DSGym provides a modular architecture that makes it easy to add tasks, agent scaffolds, and tools, positioning it as a live, extensible testbed. We curate DSGym-Tasks, a holistic task suite that standardizes and refines existing benchmarks via quality and shortcut solvability filtering. We further expand coverage with (1) DSBio: expert-derived bioinformatics tasks grounded in literature and (2) DSPredict: challenging prediction tasks spanning domains such as computer vision, molecular prediction, and single-cell perturbation. Beyond evaluation, DSGym enables agent training via execution-verified data synthesis pipeline. As a case study, we build a 2,000-example training set and trained a 4B model in DSGym that outperforms GPT-4o on standardized analysis benchmarks. Overall, DSGym enables rigorous end-to-end measurement of whether agents can plan, implement, and validate data analyses in realistic scientific context.

This paper presents ICAT, an evaluation framework for measuring coverage of diverse factual information in long-form text generation. ICAT breaks down a long output text into a list of atomic claims and not only verifies each claim through retrieval from a (reliable) knowledge source, but also computes the alignment between the atomic factual claims and various aspects expected to be presented in the output. We study three implementations of the ICAT framework, each with a different assumption on the availability of aspects and alignment method. By adopting data from the diversification task in the TREC Web Track and the ClueWeb corpus, we evaluate the ICAT framework. We demonstrate strong correlation with human judgments and provide comprehensive evaluation across multiple state-of-the-art LLMs. Our framework further offers interpretable and fine-grained analysis of diversity and coverage. Its modular design allows for easy adaptation to different domains and datasets, making it a valuable tool for evaluating the qualitative aspects of long-form responses produced by LLMs.

Biomedical data and benchmarks are highly valuable yet very limited in low-resource languages other than English such as Vietnamese. In this paper, we make use of a state-of-the-art translation model in English-Vietnamese to translate and produce both pretrained as well as supervised data in the biomedical domains. Thanks to such large-scale translation, we introduce ViPubmedT5, a pretrained Encoder-Decoder Transformer model trained on 20 million translated abstracts from the high-quality public PubMed corpus. ViPubMedT5 demonstrates state-of-the-art results on two different biomedical benchmarks in summarization and acronym disambiguation. Further, we release ViMedNLI - a new NLP task in Vietnamese translated from MedNLI using the recently public En-vi translation model and carefully refined by human experts, with evaluations of existing methods against ViPubmedT5.

Driven by the goal of eradicating language barriers on a global scale, machine translation has solidified itself as a key focus of artificial intelligence research today. However, such efforts have coalesced around a small subset of languages, leaving behind the vast majority of mostly low-resource languages. What does it take to break the 200 language barrier while ensuring safe, high quality results, all while keeping ethical considerations in mind? In No Language Left Behind, we took on this challenge by first contextualizing the need for low-resource language translation support through exploratory interviews with native speakers. Then, we created datasets and models aimed at narrowing the performance gap between low and high-resource languages. More specifically, we developed a conditional compute model based on Sparsely Gated Mixture of Experts that is trained on data obtained with novel and effective data mining techniques tailored for low-resource languages. We propose multiple architectural and training improvements to counteract overfitting while training on thousands of tasks. Critically, we evaluated the performance of over 40,000 different translation directions using a human-translated benchmark, Flores-200, and combined human evaluation with a novel toxicity benchmark covering all languages in Flores-200 to assess translation safety. Our model achieves an improvement of 44% BLEU relative to the previous state-of-the-art, laying important groundwork towards realizing a universal translation system. Finally, we open source all contributions described in this work, accessible at https://github.com/facebookresearch/fairseq/tree/nllb.

Data-to-text (D2T) generation in the biomedical domain is a promising - yet mostly unexplored - field of research. Here, we apply neural models for D2T generation to a real-world dataset consisting of package leaflets of European medicines. We show that fine-tuned transformers are able to generate realistic, multisentence text from data in the biomedical domain, yet have important limitations. We also release a new dataset (BioLeaflets) for benchmarking D2T generation models in the biomedical domain.

Recent advances in large language models (LLMs) have stepped forward the development of multilingual speech and machine translation by its reduced representation errors and incorporated external knowledge. However, both translation tasks typically utilize beam search decoding and top-1 hypothesis selection for inference. These techniques struggle to fully exploit the rich information in the diverse N-best hypotheses, making them less optimal for translation tasks that require a single, high-quality output sequence. In this paper, we propose a new generative paradigm for translation tasks, namely "GenTranslate", which builds upon LLMs to generate better results from the diverse translation versions in N-best list. Leveraging the rich linguistic knowledge and strong reasoning abilities of LLMs, our new paradigm can integrate the rich information in N-best candidates to generate a higher-quality translation result. Furthermore, to support LLM finetuning, we build and release a HypoTranslate dataset that contains over 592K hypotheses-translation pairs in 11 languages. Experiments on various speech and machine translation benchmarks (e.g., FLEURS, CoVoST-2, WMT) demonstrate that our GenTranslate significantly outperforms the state-of-the-art model.

To date, toxicity mitigation in language models has almost entirely been focused on single-language settings. As language models embrace multilingual capabilities, it's crucial our safety measures keep pace. Recognizing this research gap, our approach expands the scope of conventional toxicity mitigation to address the complexities presented by multiple languages. In the absence of sufficient annotated datasets across languages, we employ translated data to evaluate and enhance our mitigation techniques. We also compare finetuning mitigation approaches against retrieval-augmented techniques under both static and continual toxicity mitigation scenarios. This allows us to examine the effects of translation quality and the cross-lingual transfer on toxicity mitigation. We also explore how model size and data quantity affect the success of these mitigation efforts. Covering nine languages, our study represents a broad array of linguistic families and levels of resource availability, ranging from high to mid-resource languages. Through comprehensive experiments, we provide insights into the complexities of multilingual toxicity mitigation, offering valuable insights and paving the way for future research in this increasingly important field. Code and data are available at https://github.com/for-ai/goodtriever.

The rapid proliferation of LLMs has created a critical evaluation paradox: while LLMs claim multilingual proficiency, comprehensive non-machine-translated benchmarks exist for fewer than 30 languages, leaving >98% of the world's 7,000 languages in an empirical void. Traditional benchmark construction faces scaling challenges such as cost, scarcity of domain experts, and data contamination. We evaluate the validity of a simpler alternative: can translation quality alone indicate a model's broader multilingual capabilities? Through systematic evaluation of 14 models (1B-72B parameters) across 9 diverse benchmarks and 7 translation metrics, we find that translation performance is a good indicator of downstream task success (e.g., Phi-4, median Pearson r: MetricX = 0.89, xCOMET = 0.91, SSA-COMET = 0.87). These results suggest that the representational abilities supporting faithful translation overlap with those required for multilingual understanding. Translation quality, thus emerges as a strong, inexpensive first-pass proxy of multilingual performance, enabling a translation-first screening with targeted follow-up for specific tasks.

This paper introduces AFRIDOC-MT, a document-level multi-parallel translation dataset covering English and five African languages: Amharic, Hausa, Swahili, Yor\`ub\'a, and Zulu. The dataset comprises 334 health and 271 information technology news documents, all human-translated from English to these languages. We conduct document-level translation benchmark experiments by evaluating neural machine translation (NMT) models and large language models (LLMs) for translations between English and these languages, at both the sentence and pseudo-document levels. These outputs are realigned to form complete documents for evaluation. Our results indicate that NLLB-200 achieved the best average performance among the standard NMT models, while GPT-4o outperformed general-purpose LLMs. Fine-tuning selected models led to substantial performance gains, but models trained on sentences struggled to generalize effectively to longer documents. Furthermore, our analysis reveals that some LLMs exhibit issues such as under-generation, repetition of words or phrases, and off-target translations, especially for African languages.

Retrieval-augmented generation (RAG) promises grounded question answering, yet domain settings with multiple heterogeneous knowledge bases (KBs) remain challenging. In Chinese Tibetan medicine, encyclopedia entries are often dense and easy to match, which can dominate retrieval even when classics or clinical papers provide more authoritative evidence. We study a practical setting with three KBs (encyclopedia, classics, and clinical papers) and a 500-query benchmark (cutoff K{=}5) covering both single-KB and cross-KB questions. We propose two complementary methods to improve traceability, reduce hallucinations, and enable cross-KB verification. First, DAKS performs KB routing and budgeted retrieval to mitigate density-driven bias and to prioritize authoritative sources when appropriate. Second, we use an alignment graph to guide evidence fusion and coverage-aware packing, improving cross-KB evidence coverage without relying on naive concatenation. All answers are generated by a lightweight generator, openPangu-Embedded-7B. Experiments show consistent gains in routing quality and cross-KB evidence coverage, with the full system achieving the best CrossEv@5 while maintaining strong faithfulness and citation correctness.

Large Language Models (LLMs) have demonstrated strong capabilities in interpreting lengthy, complex legal and policy language. However, their reliability can be undermined by hallucinations and inconsistencies, particularly when analyzing subjective and nuanced documents. These challenges are especially critical in medical coverage policy review, where human experts must be able to rely on accurate information. In this paper, we present an approach designed to support human reviewers by making policy interpretation more efficient and interpretable. We introduce a methodology that pairs a coverage-aware retriever with symbolic rule-based reasoning to surface relevant policy language, organize it into explicit facts and rules, and generate auditable rationales. This hybrid system minimizes the number of LLM inferences required which reduces overall model cost. Notably, our approach achieves a 44% reduction in inference cost alongside a 4.5% improvement in F1 score, demonstrating both efficiency and effectiveness.

Neural Machine Translation (NMT) models are typically trained on datasets with limited exposure to Scientific, Technical and Educational domains. Translation models thus, in general, struggle with tasks that involve scientific understanding or technical jargon. Their performance is found to be even worse for low-resource Indian languages. Finding a translation dataset that tends to these domains in particular, poses a difficult challenge. In this paper, we address this by creating a multilingual parallel corpus containing more than 2.8 million rows of English-to-Indic and Indic-to-Indic high-quality translation pairs across 8 Indian languages. We achieve this by bitext mining human-translated transcriptions of NPTEL video lectures. We also finetune and evaluate NMT models using this corpus and surpass all other publicly available models at in-domain tasks. We also demonstrate the potential for generalizing to out-of-domain translation tasks by improving the baseline by over 2 BLEU on average for these Indian languages on the Flores+ benchmark. We are pleased to release our model and dataset via this link: https://huggingface.co/SPRINGLab.

This paper describes the results of SemEval 2023 task 7 -- Multi-Evidence Natural Language Inference for Clinical Trial Data (NLI4CT) -- consisting of 2 tasks, a Natural Language Inference (NLI) task, and an evidence selection task on clinical trial data. The proposed challenges require multi-hop biomedical and numerical reasoning, which are of significant importance to the development of systems capable of large-scale interpretation and retrieval of medical evidence, to provide personalized evidence-based care. Task 1, the entailment task, received 643 submissions from 40 participants, and Task 2, the evidence selection task, received 364 submissions from 23 participants. The tasks are challenging, with the majority of submitted systems failing to significantly outperform the majority class baseline on the entailment task, and we observe significantly better performance on the evidence selection task than on the entailment task. Increasing the number of model parameters leads to a direct increase in performance, far more significant than the effect of biomedical pre-training. Future works could explore the limitations of large models for generalization and numerical inference, and investigate methods to augment clinical datasets to allow for more rigorous testing and to facilitate fine-tuning. We envisage that the dataset, models, and results of this task will be useful to the biomedical NLI and evidence retrieval communities. The dataset, competition leaderboard, and website are publicly available.

How do we most effectively treat a disease or condition? Ideally, we could consult a database of evidence gleaned from clinical trials to answer such questions. Unfortunately, no such database exists; clinical trial results are instead disseminated primarily via lengthy natural language articles. Perusing all such articles would be prohibitively time-consuming for healthcare practitioners; they instead tend to depend on manually compiled systematic reviews of medical literature to inform care. NLP may speed this process up, and eventually facilitate immediate consult of published evidence. The Evidence Inference dataset was recently released to facilitate research toward this end. This task entails inferring the comparative performance of two treatments, with respect to a given outcome, from a particular article (describing a clinical trial) and identifying supporting evidence. For instance: Does this article report that chemotherapy performed better than surgery for five-year survival rates of operable cancers? In this paper, we collect additional annotations to expand the Evidence Inference dataset by 25\%, provide stronger baseline models, systematically inspect the errors that these make, and probe dataset quality. We also release an abstract only (as opposed to full-texts) version of the task for rapid model prototyping. The updated corpus, documentation, and code for new baselines and evaluations are available at http://evidence-inference.ebm-nlp.com/.

Multilingual speech translation (ST) in the medical domain enhances patient care by enabling efficient communication across language barriers, alleviating specialized workforce shortages, and facilitating improved diagnosis and treatment, particularly during pandemics. In this work, we present the first systematic study on medical ST, to our best knowledge, by releasing MultiMed-ST, a large-scale ST dataset for the medical domain, spanning all translation directions in five languages: Vietnamese, English, German, French, Traditional Chinese and Simplified Chinese, together with the models. With 290,000 samples, our dataset is the largest medical machine translation (MT) dataset and the largest many-to-many multilingual ST among all domains. Secondly, we present the most extensive analysis study in ST research to date, including: empirical baselines, bilingual-multilingual comparative study, end-to-end vs. cascaded comparative study, task-specific vs. multi-task sequence-to-sequence (seq2seq) comparative study, code-switch analysis, and quantitative-qualitative error analysis. All code, data, and models are available online: https://github.com/leduckhai/MultiMed-ST.

Most biomedical pretrained language models are monolingual and cannot handle the growing cross-lingual requirements. The scarcity of non-English domain corpora, not to mention parallel data, poses a significant hurdle in training multilingual biomedical models. Since knowledge forms the core of domain-specific corpora and can be translated into various languages accurately, we propose a model called KBioXLM, which transforms the multilingual pretrained model XLM-R into the biomedical domain using a knowledge-anchored approach. We achieve a biomedical multilingual corpus by incorporating three granularity knowledge alignments (entity, fact, and passage levels) into monolingual corpora. Then we design three corresponding training tasks (entity masking, relation masking, and passage relation prediction) and continue training on top of the XLM-R model to enhance its domain cross-lingual ability. To validate the effectiveness of our model, we translate the English benchmarks of multiple tasks into Chinese. Experimental results demonstrate that our model significantly outperforms monolingual and multilingual pretrained models in cross-lingual zero-shot and few-shot scenarios, achieving improvements of up to 10+ points. Our code is publicly available at https://github.com/ngwlh-gl/KBioXLM.

During a virus's evolution,various regions of the genome are subjected to distinct levels of functional constraints.Combined with factors like codon bias and DNA repair efficiency,these constraints contribute to unique mutation patterns within the genome or a specific gene. In this project, we harnessed the power of Large Language Models(LLMs) to predict the evolution of SARS-CoV-2. By treating the mutation process from one generation to the next as a translation task, we trained a transformer model, called VirusT5, to capture the mutation patterns underlying SARS-CoV-2 evolution. We evaluated the VirusT5's ability to detect these mutation patterns including its ability to identify mutation hotspots and explored the potential of using VirusT5 to predict future virus variants. Our findings demonstrate the feasibility of using a large language model to model viral evolution as a translation process. This study establishes the groundbreaking concept of "mutation-as-translation," paving the way for new methodologies and tools for combating virus threats

One of the biggest challenges hindering progress in low-resource and multilingual machine translation is the lack of good evaluation benchmarks. Current evaluation benchmarks either lack good coverage of low-resource languages, consider only restricted domains, or are low quality because they are constructed using semi-automatic procedures. In this work, we introduce the FLORES-101 evaluation benchmark, consisting of 3001 sentences extracted from English Wikipedia and covering a variety of different topics and domains. These sentences have been translated in 101 languages by professional translators through a carefully controlled process. The resulting dataset enables better assessment of model quality on the long tail of low-resource languages, including the evaluation of many-to-many multilingual translation systems, as all translations are multilingually aligned. By publicly releasing such a high-quality and high-coverage dataset, we hope to foster progress in the machine translation community and beyond.

Addressing the imminent shortfall of 10 million health workers by 2030, predominantly in Low- and Middle-Income Countries (LMICs), this paper introduces an innovative approach that harnesses the power of Large Language Models (LLMs) integrated with machine translation models. This solution is engineered to meet the unique needs of Community Health Workers (CHWs), overcoming language barriers, cultural sensitivities, and the limited availability of medical dialog datasets. I have crafted a model that not only boasts superior translation capabilities but also undergoes rigorous fine-tuning on open-source datasets to ensure medical accuracy and is equipped with comprehensive safety features to counteract the risks of misinformation. Featuring a modular design, this approach is specifically structured for swift adaptation across various linguistic and cultural contexts, utilizing open-source components to significantly reduce healthcare operational costs. This strategic innovation markedly improves the accessibility and quality of healthcare services by providing CHWs with contextually appropriate medical knowledge and diagnostic tools. This paper highlights the transformative impact of this context-aware LLM, underscoring its crucial role in addressing the global healthcare workforce deficit and propelling forward healthcare outcomes in LMICs.

Large language models (LLMs) have demonstrated impressive capabilities in general scenarios, exhibiting a level of aptitude that approaches, in some aspects even surpasses, human-level intelligence. Among their numerous skills, the translation abilities of LLMs have received considerable attention. In contrast to traditional machine translation that focuses solely on source-target mapping, LLM-based translation can potentially mimic the human translation process that takes many preparatory steps to ensure high-quality translation. This work aims to explore this possibility by proposing the MAPS framework, which stands for Multi-Aspect Prompting and Selection. Specifically, we enable LLMs to first analyze the given source text and extract three aspects of translation-related knowledge: keywords, topics and relevant demonstrations to guide the translation process. To filter out the noisy and unhelpful knowledge, we employ a selection mechanism based on quality estimation. Experiments suggest that MAPS brings significant and consistent improvements over text-davinci-003 and Alpaca on eight translation directions from the latest WMT22 test sets. Our further analysis shows that the extracted knowledge is critical in resolving up to 59% of hallucination mistakes in translation. Code is available at https://github.com/zwhe99/MAPS-mt.

Minority languages in China, such as Tibetan, Uyghur, and Traditional Mongolian, face significant challenges due to their unique writing systems, which differ from international standards. This discrepancy has led to a severe lack of relevant corpora, particularly for supervised tasks like headline generation. To address this gap, we introduce a novel dataset, Chinese Minority Headline Generation (CMHG), which includes 100,000 entries for Tibetan, and 50,000 entries each for Uyghur and Mongolian, specifically curated for headline generation tasks. Additionally, we propose a high-quality test set annotated by native speakers, designed to serve as a benchmark for future research in this domain. We hope this dataset will become a valuable resource for advancing headline generation in Chinese minority languages and contribute to the development of related benchmarks.

Clinical trials are fundamental in developing new drugs, medical devices, and treatments. However, they are often time-consuming and have low success rates. Although there have been initial attempts to create large language models (LLMs) for clinical trial design and patient-trial matching, these models remain task-specific and not adaptable to diverse clinical trial tasks. To address this challenge, we propose a clinical trial foundation model named Panacea, designed to handle multiple tasks, including trial search, trial summarization, trial design, and patient-trial matching. We also assemble a large-scale dataset, named TrialAlign, of 793,279 trial documents and 1,113,207 trial-related scientific papers, to infuse clinical knowledge into the model by pre-training. We further curate TrialInstruct, which has 200,866 of instruction data for fine-tuning. These resources enable Panacea to be widely applicable for a range of clinical trial tasks based on user requirements. We evaluated Panacea on a new benchmark, named TrialPanorama, which covers eight clinical trial tasks. Our method performed the best on seven of the eight tasks compared to six cutting-edge generic or medicine-specific LLMs. Specifically, Panacea showed great potential to collaborate with human experts in crafting the design of eligibility criteria, study arms, and outcome measures, in multi-round conversations. In addition, Panacea achieved 14.42% improvement in patient-trial matching, 41.78% to 52.02% improvement in trial search, and consistently ranked at the top for five aspects of trial summarization. Our approach demonstrates the effectiveness of Panacea in clinical trials and establishes a comprehensive resource, including training data, model, and benchmark, for developing clinical trial foundation models, paving the path for AI-based clinical trial development.

Machine translation for Vietnamese-English in the medical domain is still an under-explored research area. In this paper, we introduce MedEV -- a high-quality Vietnamese-English parallel dataset constructed specifically for the medical domain, comprising approximately 360K sentence pairs. We conduct extensive experiments comparing Google Translate, ChatGPT (gpt-3.5-turbo), state-of-the-art Vietnamese-English neural machine translation models and pre-trained bilingual/multilingual sequence-to-sequence models on our new MedEV dataset. Experimental results show that the best performance is achieved by fine-tuning "vinai-translate" for each translation direction. We publicly release our dataset to promote further research.

Research in NLP lacks geographic diversity, and the question of how NLP can be scaled to low-resourced languages has not yet been adequately solved. "Low-resourced"-ness is a complex problem going beyond data availability and reflects systemic problems in society. In this paper, we focus on the task of Machine Translation (MT), that plays a crucial role for information accessibility and communication worldwide. Despite immense improvements in MT over the past decade, MT is centered around a few high-resourced languages. As MT researchers cannot solve the problem of low-resourcedness alone, we propose participatory research as a means to involve all necessary agents required in the MT development process. We demonstrate the feasibility and scalability of participatory research with a case study on MT for African languages. Its implementation leads to a collection of novel translation datasets, MT benchmarks for over 30 languages, with human evaluations for a third of them, and enables participants without formal training to make a unique scientific contribution. Benchmarks, models, data, code, and evaluation results are released under https://github.com/masakhane-io/masakhane-mt.

While large language models (LLMs) have been increasingly adopted for machine translation (MT), their performance for specialist domains such as medicine and law remains an open challenge. Prior work has shown that LLMs can be domain-adapted at test-time by retrieving targeted few-shot demonstrations or terminologies for inclusion in the prompt. Meanwhile, for general-purpose LLM MT, recent studies have found some success in generating similarly useful domain knowledge from an LLM itself, prior to translation. Our work studies domain-adapted MT with LLMs through a careful prompting setup, finding that demonstrations consistently outperform terminology, and retrieval consistently outperforms generation. We find that generating demonstrations with weaker models can close the gap with larger model's zero-shot performance. Given the effectiveness of demonstrations, we perform detailed analyses to understand their value. We find that domain-specificity is particularly important, and that the popular multi-domain benchmark is testing adaptation to a particular writing style more so than to a specific domain.

Language barriers in scientific documents hinder the diffusion and development of science and technologies. However, prior efforts in translating such documents largely overlooked the information in layouts. To bridge the gap, we introduce PDFMathTranslate, the world's first open-source software for translating scientific documents while preserving layouts. Leveraging the most recent advances in large language models and precise layout detection, we contribute to the community with key improvements in precision, flexibility, and efficiency. The work has been open-sourced at https://github.com/byaidu/pdfmathtranslate with more than 222k downloads.

Meta-analyses statistically aggregate the findings of different randomized controlled trials (RCTs) to assess treatment effectiveness. Because this yields robust estimates of treatment effectiveness, results from meta-analyses are considered the strongest form of evidence. However, rigorous evidence syntheses are time-consuming and labor-intensive, requiring manual extraction of data from individual trials to be synthesized. Ideally, language technologies would permit fully automatic meta-analysis, on demand. This requires accurately extracting numerical results from individual trials, which has been beyond the capabilities of natural language processing (NLP) models to date. In this work, we evaluate whether modern large language models (LLMs) can reliably perform this task. We annotate (and release) a modest but granular evaluation dataset of clinical trial reports with numerical findings attached to interventions, comparators, and outcomes. Using this dataset, we evaluate the performance of seven LLMs applied zero-shot for the task of conditionally extracting numerical findings from trial reports. We find that massive LLMs that can accommodate lengthy inputs are tantalizingly close to realizing fully automatic meta-analysis, especially for dichotomous (binary) outcomes (e.g., mortality). However, LLMs -- including ones trained on biomedical texts -- perform poorly when the outcome measures are complex and tallying the results requires inference. This work charts a path toward fully automatic meta-analysis of RCTs via LLMs, while also highlighting the limitations of existing models for this aim.

This research article examines the effectiveness of various pretraining strategies for developing machine translation models tailored to low-resource languages. Although this work considers several low-resource languages, including Afrikaans, Swahili, and Zulu, the translation model is specifically developed for Lingala, an under-resourced African language, building upon the pretraining approach introduced by Reid and Artetxe (2021), originally designed for high-resource languages. Through a series of comprehensive experiments, we explore different pretraining methodologies, including the integration of multiple languages and the use of both monolingual and parallel data during the pretraining phase. Our findings indicate that pretraining on multiple languages and leveraging both monolingual and parallel data significantly enhance translation quality. This study offers valuable insights into effective pretraining strategies for low-resource machine translation, helping to bridge the performance gap between high-resource and low-resource languages. The results contribute to the broader goal of developing more inclusive and accurate NLP models for marginalized communities and underrepresented populations. The code and datasets used in this study are publicly available to facilitate further research and ensure reproducibility, with the exception of certain data that may no longer be accessible due to changes in public availability.

Access to Kurdish medicine brochures is limited, depriving Kurdish-speaking communities of critical health information. To address this problem, we developed a specialized Machine Translation (MT) model to translate English medicine brochures into Sorani Kurdish using a parallel corpus of 22,940 aligned sentence pairs from 319 brochures, sourced from two pharmaceutical companies in the Kurdistan Region of Iraq (KRI). We trained a Statistical Machine Translation (SMT) model using the Moses toolkit, conducting seven experiments that resulted in BLEU scores ranging from 22.65 to 48.93. We translated three new brochures to improve the evaluation process and encountered unknown words. We addressed unknown words through post-processing with a medical dictionary, resulting in BLEU scores of 56.87, 31.05, and 40.01. Human evaluation by native Kurdish-speaking pharmacists, physicians, and medicine users showed that 50% of professionals found the translations consistent, while 83.3% rated them accurate. Among users, 66.7% considered the translations clear and felt confident using the medications.

Large Language Models (LLMs) have demonstrated significant potential in handling specialized tasks, including medical problem-solving. However, most studies predominantly focus on English-language contexts. This study introduces a novel benchmark dataset based on Polish medical licensing and specialization exams (LEK, LDEK, PES) taken by medical doctor candidates and practicing doctors pursuing specialization. The dataset was web-scraped from publicly available resources provided by the Medical Examination Center and the Chief Medical Chamber. It comprises over 24,000 exam questions, including a subset of parallel Polish-English corpora, where the English portion was professionally translated by the examination center for foreign candidates. By creating a structured benchmark from these existing exam questions, we systematically evaluate state-of-the-art LLMs, including general-purpose, domain-specific, and Polish-specific models, and compare their performance against human medical students. Our analysis reveals that while models like GPT-4o achieve near-human performance, significant challenges persist in cross-lingual translation and domain-specific understanding. These findings underscore disparities in model performance across languages and medical specialties, highlighting the limitations and ethical considerations of deploying LLMs in clinical practice.

Hit-like molecular generation with therapeutic potential is essential for target-specific drug discovery. However, the field lacks heterogeneous data and unified frameworks for integrating diverse molecular representations. To bridge this gap, we introduce TextOmics, a pioneering benchmark that establishes one-to-one correspondences between omics expressions and molecular textual descriptions. TextOmics provides a heterogeneous dataset that facilitates molecular generation through representations alignment. Built upon this foundation, we propose ToDi, a generative framework that jointly conditions on omics expressions and molecular textual descriptions to produce biologically relevant, chemically valid, hit-like molecules. ToDi leverages two encoders (OmicsEn and TextEn) to capture multi-level biological and semantic associations, and develops conditional diffusion (DiffGen) for controllable generation. Extensive experiments confirm the effectiveness of TextOmics and demonstrate ToDi outperforms existing state-of-the-art approaches, while also showcasing remarkable potential in zero-shot therapeutic molecular generation. Sources are available at: https://github.com/hala-ToDi.

An important challenge in machine translation (MT) is to generate high-quality and diverse translations. Prior work has shown that the estimated likelihood from the MT model correlates poorly with translation quality. In contrast, quality evaluation metrics (such as COMET or BLEURT) exhibit high correlations with human judgments, which has motivated their use as rerankers (such as quality-aware and minimum Bayes risk decoding). However, relying on a single translation with high estimated quality increases the chances of "gaming the metric''. In this paper, we address the problem of sampling a set of high-quality and diverse translations. We provide a simple and effective way to avoid over-reliance on noisy quality estimates by using them as the energy function of a Gibbs distribution. Instead of looking for a mode in the distribution, we generate multiple samples from high-density areas through the Metropolis-Hastings algorithm, a simple Markov chain Monte Carlo approach. The results show that our proposed method leads to high-quality and diverse outputs across multiple language pairs (Englishleftrightarrow{German, Russian}) with two strong decoder-only LLMs (Alma-7b, Tower-7b).

Recent studies have revealed a number of pathologies of neural machine translation (NMT) systems. Hypotheses explaining these mostly suggest there is something fundamentally wrong with NMT as a model or its training algorithm, maximum likelihood estimation (MLE). Most of this evidence was gathered using maximum a posteriori (MAP) decoding, a decision rule aimed at identifying the highest-scoring translation, i.e. the mode. We argue that the evidence corroborates the inadequacy of MAP decoding more than casts doubt on the model and its training algorithm. In this work, we show that translation distributions do reproduce various statistics of the data well, but that beam search strays from such statistics. We show that some of the known pathologies and biases of NMT are due to MAP decoding and not to NMT's statistical assumptions nor MLE. In particular, we show that the most likely translations under the model accumulate so little probability mass that the mode can be considered essentially arbitrary. We therefore advocate for the use of decision rules that take into account the translation distribution holistically. We show that an approximation to minimum Bayes risk decoding gives competitive results confirming that NMT models do capture important aspects of translation well in expectation.

Background: Recent advances in large language models highlight the need for high-quality multilingual medical datasets. While Japan leads globally in CT scanner deployment and utilization, the lack of large-scale Japanese radiology datasets has hindered the development of specialized language models for medical imaging analysis. Objective: To develop a comprehensive Japanese CT report dataset through machine translation and establish a specialized language model for structured finding classification. Additionally, to create a rigorously validated evaluation dataset through expert radiologist review. Methods: We translated the CT-RATE dataset (24,283 CT reports from 21,304 patients) into Japanese using GPT-4o mini. The training dataset consisted of 22,778 machine-translated reports, while the validation dataset included 150 radiologist-revised reports. We developed CT-BERT-JPN based on "tohoku-nlp/bert-base-japanese-v3" architecture for extracting 18 structured findings from Japanese radiology reports. Results: Translation metrics showed strong performance with BLEU scores of 0.731 and 0.690, and ROUGE scores ranging from 0.770 to 0.876 for Findings and from 0.748 to 0.857 for Impression sections. CT-BERT-JPN demonstrated superior performance compared to GPT-4o in 11 out of 18 conditions, including lymphadenopathy (+14.2%), interlobular septal thickening (+10.9%), and atelectasis (+7.4%). The model maintained F1 scores exceeding 0.95 in 14 out of 18 conditions and achieved perfect scores in four conditions. Conclusions: Our study establishes a robust Japanese CT report dataset and demonstrates the effectiveness of a specialized language model for structured finding classification. The hybrid approach of machine translation and expert validation enables the creation of large-scale medical datasets while maintaining high quality.

Natural language tasks like Named Entity Recognition (NER) in the clinical domain on non-English texts can be very time-consuming and expensive due to the lack of annotated data. Cross-lingual transfer (CLT) is a way to circumvent this issue thanks to the ability of multilingual large language models to be fine-tuned on a specific task in one language and to provide high accuracy for the same task in another language. However, other methods leveraging translation models can be used to perform NER without annotated data in the target language, by either translating the training set or test set. This paper compares cross-lingual transfer with these two alternative methods, to perform clinical NER in French and in German without any training data in those languages. To this end, we release MedNERF a medical NER test set extracted from French drug prescriptions and annotated with the same guidelines as an English dataset. Through extensive experiments on this dataset and on a German medical dataset (Frei and Kramer, 2021), we show that translation-based methods can achieve similar performance to CLT but require more care in their design. And while they can take advantage of monolingual clinical language models, those do not guarantee better results than large general-purpose multilingual models, whether with cross-lingual transfer or translation.

Training and evaluating language models increasingly requires the construction of meta-datasets --diverse collections of curated data with clear provenance. Natural language prompting has recently lead to improved zero-shot generalization by transforming existing, supervised datasets into a diversity of novel pretraining tasks, highlighting the benefits of meta-dataset curation. While successful in general-domain text, translating these data-centric approaches to biomedical language modeling remains challenging, as labeled biomedical datasets are significantly underrepresented in popular data hubs. To address this challenge, we introduce BigBIO a community library of 126+ biomedical NLP datasets, currently covering 12 task categories and 10+ languages. BigBIO facilitates reproducible meta-dataset curation via programmatic access to datasets and their metadata, and is compatible with current platforms for prompt engineering and end-to-end few/zero shot language model evaluation. We discuss our process for task schema harmonization, data auditing, contribution guidelines, and outline two illustrative use cases: zero-shot evaluation of biomedical prompts and large-scale, multi-task learning. BigBIO is an ongoing community effort and is available at https://github.com/bigscience-workshop/biomedical

We show that content on the web is often translated into many languages, and the low quality of these multi-way translations indicates they were likely created using Machine Translation (MT). Multi-way parallel, machine generated content not only dominates the translations in lower resource languages; it also constitutes a large fraction of the total web content in those languages. We also find evidence of a selection bias in the type of content which is translated into many languages, consistent with low quality English content being translated en masse into many lower resource languages, via MT. Our work raises serious concerns about training models such as multilingual large language models on both monolingual and bilingual data scraped from the web.

Interest in neural machine translation has grown rapidly as its effectiveness has been demonstrated across language and data scenarios. New research regularly introduces architectural and algorithmic improvements that lead to significant gains over "vanilla" NMT implementations. However, these new techniques are rarely evaluated in the context of previously published techniques, specifically those that are widely used in state-of-theart production and shared-task systems. As a result, it is often difficult to determine whether improvements from research will carry over to systems deployed for real-world use. In this work, we recommend three specific methods that are relatively easy to implement and result in much stronger experimental systems. Beyond reporting significantly higher BLEU scores, we conduct an in-depth analysis of where improvements originate and what inherent weaknesses of basic NMT models are being addressed. We then compare the relative gains afforded by several other techniques proposed in the literature when starting with vanilla systems versus our stronger baselines, showing that experimental conclusions may change depending on the baseline chosen. This indicates that choosing a strong baseline is crucial for reporting reliable experimental results.

The effective application of foundation models to translational research in immune-mediated diseases requires multimodal patient-level representations that can capture complex phenotypes emerging from multicellular interactions. Yet most current biological foundation models focus only on single-cell resolution and are evaluated on technical metrics often disconnected from actual drug development tasks and challenges. Here, we introduce EVA, the first cross-species, multimodal foundation model of immunology and inflammation, a therapeutic area where shared pathogenic mechanisms create unique opportunities for transfer learning. EVA harmonizes transcriptomics data across species, platforms, and resolutions, and integrates histology data to produce rich, unified patient representations. We establish clear scaling laws, demonstrating that increasing model size and compute translates to improvements in both pretraining and downstream tasks performance. We introduce a comprehensive evaluation suite of 39 tasks spanning the drug development pipeline: zero-shot target efficacy and gene function prediction for discovery, cross-species or cross-diseases molecular perturbations for preclinical development, and patient stratification with treatment response prediction or disease activity prediction for clinical trials applications. We benchmark EVA against several state-of-the-art biological foundation models and baselines on these tasks, and demonstrate state-of-the-art results on each task category. Using mechanistic interpretability, we further identify biological meaningful features, revealing intertwined representations across species and technologies. We release an open version of EVA for transcriptomics to accelerate research on immune-mediated diseases.

This paper presents the OPUS ecosystem with a focus on the development of open machine translation models and tools, and their integration into end-user applications, development platforms and professional workflows. We discuss our on-going mission of increasing language coverage and translation quality, and also describe on-going work on the development of modular translation models and speed-optimized compact solutions for real-time translation on regular desktops and small devices.

The dominance of colonial languages in African education and scientific communication limits how hundreds of millions of speakers of African languages access and produce scientific knowledge. A core obstacle is the lack of established scientific terminology in these languages. We introduce AfriScience-MT, a parallel corpus covering six African languages (Amharic, Hausa, Luganda, Northern Sotho, Yorùbá, and isiZulu) across 11 scientific domains. Professional translators, working with expert science communicators, translated plain-language summaries of scientific papers into each target language and created new terms where none existed. We benchmark machine translation systems and large language models in zero-shot, few-shot, and fine-tuned settings. Our results show that closed-source models outperform all open-source models at both the sentence and document levels: GPT-5.4 and Gemini-3.1-Flash-Lite lead with average sentence-level COMET scores of 68.3 and 68.0, respectively, and tie at an average document-level COMET of 48.3. Among open systems, fine-tuned NLLB-1.3B reaches 67.3 at the sentence level, and TranslateGemma-12B reaches 44.0 at the document level with 1-shot in-context learning. We release AfriScience-MT to support benchmarking and document-level scientific MT for African languages.

Recently, it has been found that monolingual English language models can be used as knowledge bases. Instead of structural knowledge base queries, masked sentences such as "Paris is the capital of [MASK]" are used as probes. We translate the established benchmarks TREx and GoogleRE into 53 languages. Working with mBERT, we investigate three questions. (i) Can mBERT be used as a multilingual knowledge base? Most prior work only considers English. Extending research to multiple languages is important for diversity and accessibility. (ii) Is mBERT's performance as knowledge base language-independent or does it vary from language to language? (iii) A multilingual model is trained on more text, e.g., mBERT is trained on 104 Wikipedias. Can mBERT leverage this for better performance? We find that using mBERT as a knowledge base yields varying performance across languages and pooling predictions across languages improves performance. Conversely, mBERT exhibits a language bias; e.g., when queried in Italian, it tends to predict Italy as the country of origin.

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of biomedically fine-tuned LLMs against their general-purpose counterparts on a variety of clinical tasks. We evaluated their performance on clinical case challenges from the New England Journal of Medicine (NEJM) and the Journal of the American Medical Association (JAMA) and on several clinical tasks (e.g., information extraction, document summarization, and clinical coding). Using benchmarks specifically chosen to be likely outside the fine-tuning datasets of biomedical models, we found that biomedical LLMs mostly perform inferior to their general-purpose counterparts, especially on tasks not focused on medical knowledge. While larger models showed similar performance on case tasks (e.g., OpenBioLLM-70B: 66.4% vs. Llama-3-70B-Instruct: 65% on JAMA cases), smaller biomedical models showed more pronounced underperformance (e.g., OpenBioLLM-8B: 30% vs. Llama-3-8B-Instruct: 64.3% on NEJM cases). Similar trends were observed across the CLUE (Clinical Language Understanding Evaluation) benchmark tasks, with general-purpose models often performing better on text generation, question answering, and coding tasks. Our results suggest that fine-tuning LLMs to biomedical data may not provide the expected benefits and may potentially lead to reduced performance, challenging prevailing assumptions about domain-specific adaptation of LLMs and highlighting the need for more rigorous evaluation frameworks in healthcare AI. Alternative approaches, such as retrieval-augmented generation, may be more effective in enhancing the biomedical capabilities of LLMs without compromising their general knowledge.

Modern Large Language Models (LLMs) are often criticized for producing repetitive and homogeneous text, despite possessing vast latent vocabularies. While previous research has focused on model knowledge and training data, we investigate the role of decoding mechanics in suppressing linguistic diversity. We introduce the Word Coverage Score (WCS), a metric that quantifies the extent to which contextually appropriate human vocabulary is mathematically pruned by standard sampling filters (e.g., Top-p, Top-k, and Min-p). Rather than assessing static knowledge, the WCS measures the lexical survival rate of low-frequency, high-information human words as a function of sampling parameters. By auditing open-weight models on human-authored corpus fragments, we identify which logical lexical choices are rendered unreachable by the decoder, even when they reside within the probability space. Our results provide quantitative evidence that industry-standard sampling defaults act as unintended censorship mechanisms, smoothing the unique textures of human expression into a homogenized discourse. The WCS offers a rigorous framework for optimizing the trade-off between text coherence and lexical richness, providing a diagnostic tool for preserving the diversity of human language in generative models.

Multimodal Large Language Models (MLLMs) have significantly advanced document understanding, yet current Doc-VQA evaluations score only the final answer and leave the supporting evidence unchecked. This answer-only approach masks a critical failure mode: a model can land on the correct answer while grounding it in the wrong passage -- a critical risk in high-stakes domains like law, finance, and medicine, where every conclusion must be traceable to a specific source region. To address this, we introduce CiteVQA, a benchmark that requires models to return element-level bounding-box citations alongside each answer, evaluating both jointly. CiteVQA comprises 1,897 questions across 711 PDFs spanning seven domains and two languages, averaging 40.6 pages per document. To ensure fidelity and scalability, the ground-truth citations are generated by an automated pipeline-which identifies crucial evidence via masking ablation-and are subsequently validated through expert review. At the core of our evaluation is Strict Attributed Accuracy (SAA), which credits a prediction only when the answer and the cited region are both correct. Auditing 20 MLLMs reveals a pervasive Attribution Hallucination: models frequently produce the right answer while citing the wrong region. The strongest system (Gemini-3.1-Pro-Preview) achieves an SAA of only 76.0, and the strongest open-source MLLM reaches just 22.5. Ultimately, towards trustworthy document intelligence, CiteVQA exposes a reliability gap that answer-only evaluations overlook, providing the instrumentation needed to close it. Our repository is available at https://github.com/opendatalab/CiteVQA.

We describe the JD Explore Academy's submission of the WMT 2022 shared general translation task. We participated in all high-resource tracks and one medium-resource track, including Chinese-English, German-English, Czech-English, Russian-English, and Japanese-English. We push the limit of our previous work -- bidirectional training for translation by scaling up two main factors, i.e. language pairs and model sizes, namely the Vega-MT system. As for language pairs, we scale the "bidirectional" up to the "multidirectional" settings, covering all participating languages, to exploit the common knowledge across languages, and transfer them to the downstream bilingual tasks. As for model sizes, we scale the Transformer-Big up to the extremely large model that owns nearly 4.7 Billion parameters, to fully enhance the model capacity for our Vega-MT. Also, we adopt the data augmentation strategies, e.g. cycle translation for monolingual data, and bidirectional self-training for bilingual and monolingual data, to comprehensively exploit the bilingual and monolingual data. To adapt our Vega-MT to the general domain test set, generalization tuning is designed. Based on the official automatic scores of constrained systems, in terms of the sacreBLEU shown in Figure-1, we got the 1st place on {Zh-En (33.5), En-Zh (49.7), De-En (33.7), En-De (37.8), Cs-En (54.9), En-Cs (41.4) and En-Ru (32.7)}, 2nd place on {Ru-En (45.1) and Ja-En (25.6)}, and 3rd place on {En-Ja(41.5)}, respectively; W.R.T the COMET, we got the 1st place on {Zh-En (45.1), En-Zh (61.7), De-En (58.0), En-De (63.2), Cs-En (74.7), Ru-En (64.9), En-Ru (69.6) and En-Ja (65.1)}, 2nd place on {En-Cs (95.3) and Ja-En (40.6)}, respectively.

Nowadays the medical domain is receiving more and more attention in applications involving Artificial Intelligence. Clinicians have to deal with an enormous amount of unstructured textual data to make a conclusion about patients' health in their everyday life. Argument mining helps to provide a structure to such data by detecting argumentative components in the text and classifying the relations between them. However, as it is the case for many tasks in Natural Language Processing in general and in medical text processing in particular, the large majority of the work on computational argumentation has been done only for English. This is also the case with the only dataset available for argumentation in the medical domain, namely, the annotated medical data of abstracts of Randomized Controlled Trials (RCT) from the MEDLINE database. In order to mitigate the lack of annotated data for other languages, we empirically investigate several strategies to perform argument mining and classification in medical texts for a language for which no annotated data is available. This project shows that automatically translating and project annotations from English to a target language (Spanish) is an effective way to generate annotated data without manual intervention. Furthermore, our experiments demonstrate that the translation and projection approach outperforms zero-shot cross-lingual approaches using a large masked multilingual language model. Finally, we show how the automatically generated data in Spanish can also be used to improve results in the original English evaluation setting.

This study provides a comprehensive analysis of artificial intelligence (AI) contribution to translation industry (ACTI) research, synthesizing it over forty-one years from 1980-2024. 13220 articles were retrieved from three sources, namely WoS, Scopus, and Lens. We provided two types of analysis, viz., scientometric and thematic, focusing on cluster, subject categories, keywords, burstness, centrality and research centers as for the former. For the latter, we thematically review 18 articles, selected purposefully from the articles involved, centering on purpose, approach, findings, and contribution to ACTI future directions. The findings reveal that in the past AI contribution to translation industry was not rigorous, resulting in rule-based machine translation and statistical machine translation whose output was not satisfactory. However, the more AI develops, the more machine translation develops, incorporating Neural Networking Algorithms and (Deep) Language Learning Models like ChatGPT whose translation output has developed considerably. However, much rigorous research is still needed to overcome several problems encountering translation industry, specifically concerning low-source languages, multi-dialectical and free word order languages, and cultural and religious registers.

Automated text simplification aims to produce simple versions of complex texts. This task is especially useful in the medical domain, where the latest medical findings are typically communicated via complex and technical articles. This creates barriers for laypeople seeking access to up-to-date medical findings, consequently impeding progress on health literacy. Most existing work on medical text simplification has focused on monolingual settings, with the result that such evidence would be available only in just one language (most often, English). This work addresses this limitation via multilingual simplification, i.e., directly simplifying complex texts into simplified texts in multiple languages. We introduce MultiCochrane, the first sentence-aligned multilingual text simplification dataset for the medical domain in four languages: English, Spanish, French, and Farsi. We evaluate fine-tuned and zero-shot models across these languages, with extensive human assessments and analyses. Although models can now generate viable simplified texts, we identify outstanding challenges that this dataset might be used to address.

Systematic literature review is essential for evidence-based medicine, requiring comprehensive analysis of clinical trial publications. However, the application of artificial intelligence (AI) models for medical literature mining has been limited by insufficient training and evaluation across broad therapeutic areas and diverse tasks. Here, we present LEADS, an AI foundation model for study search, screening, and data extraction from medical literature. The model is trained on 633,759 instruction data points in LEADSInstruct, curated from 21,335 systematic reviews, 453,625 clinical trial publications, and 27,015 clinical trial registries. We showed that LEADS demonstrates consistent improvements over four cutting-edge generic large language models (LLMs) on six tasks. Furthermore, LEADS enhances expert workflows by providing supportive references following expert requests, streamlining processes while maintaining high-quality results. A study with 16 clinicians and medical researchers from 14 different institutions revealed that experts collaborating with LEADS achieved a recall of 0.81 compared to 0.77 experts working alone in study selection, with a time savings of 22.6%. In data extraction tasks, experts using LEADS achieved an accuracy of 0.85 versus 0.80 without using LEADS, alongside a 26.9% time savings. These findings highlight the potential of specialized medical literature foundation models to outperform generic models, delivering significant quality and efficiency benefits when integrated into expert workflows for medical literature mining.

We present TranslateGemma, a suite of open machine translation models based on the Gemma 3 foundation models. To enhance the inherent multilingual capabilities of Gemma 3 for the translation task, we employ a two-stage fine-tuning process. First, supervised fine-tuning is performed using a rich mixture of high-quality large-scale synthetic parallel data generated via state-of-the-art models and human-translated parallel data. This is followed by a reinforcement learning phase, where we optimize translation quality using an ensemble of reward models, including MetricX-QE and AutoMQM, targeting translation quality. We demonstrate the effectiveness of TranslateGemma with human evaluation on the WMT25 test set across 10 language pairs and with automatic evaluation on the WMT24++ benchmark across 55 language pairs. Automatic metrics show consistent and substantial gains over the baseline Gemma 3 models across all sizes. Notably, smaller TranslateGemma models often achieve performance comparable to larger baseline models, offering improved efficiency. We also show that TranslateGemma models retain strong multimodal capabilities, with enhanced performance on the Vistra image translation benchmark. The release of the open TranslateGemma models aims to provide the research community with powerful and adaptable tools for machine translation.

Despite the success of large language models (LLMs) on general-purpose tasks, their performance in highly specialized domains such as biomedicine remains unsatisfactory. A key limitation is the inability of LLMs to effectively leverage biomedical tools, which clinical experts and biomedical researchers rely on extensively in daily workflows. While recent general-domain tool-calling datasets have substantially improved the capabilities of LLM agents, existing efforts in the biomedical domain largely rely on in-context learning and restrict models to a small set of tools. To address this gap, we introduce BioTool, a comprehensive biomedical tool-calling dataset designed for fine-tuning LLMs. BioTool comprises 34 frequently used tools collected from the NCBI, Ensembl, and UniProt databases, along with 7,040 high-quality, human-verified query-API call pairs spanning variation, genomics, proteomics, evolution, and general biology. Fine-tuning a 4-billion-parameter LLM on BioTool yields substantial improvements in biomedical tool-calling performance, outperforming cutting-edge commercial LLMs such as GPT-5.1. Furthermore, human expert evaluations demonstrate that integrating a BioTool-fine-tuned tool caller significantly improves downstream answer quality compared to the same LLM without tool usage, highlighting the effectiveness of BioTool in enhancing the biomedical capabilities of LLMs. The full dataset and evaluation code are available at https://github.com/gxx27/BioTool

Systematic literature reviews are essential for synthesizing scientific evidence but are costly, difficult to scale and time-intensive, creating bottlenecks for evidence-based policy. We study whether large language models can automate the complete systematic review workflow, from article retrieval, article screening, data extraction to report synthesis. Applied to epidemiological reviews of nine WHO-designated priority pathogens and validated against expert-curated ground truth, our open-source agentic pipeline (AgentSLR) achieves performance comparable to human researchers while reducing review time from approximately 7 weeks to 20 hours (a 58x speed-up). Our comparison of five frontier models reveals that performance on SLR is driven less by model size or inference cost than by each model's distinctive capabilities. Through human-in-the-loop validation, we identify key failure modes. Our results demonstrate that agentic AI can substantially accelerate scientific evidence synthesis in specialised domains.

Recent advancements in large language models (LLM) capable of processing extremely long texts highlight the need for a dedicated evaluation benchmark to assess their long-context capabilities. However, existing methods, like the needle-in-a-haystack test, do not effectively assess whether these models fully utilize contextual information, raising concerns about the reliability of current evaluation techniques. To thoroughly examine the effectiveness of existing benchmarks, we introduce a new metric called information coverage (IC), which quantifies the proportion of the input context necessary for answering queries. Our findings indicate that current benchmarks exhibit low IC; although the input context may be extensive, the actual usable context is often limited. To address this, we present ETHIC, a novel benchmark designed to assess LLMs' ability to leverage the entire context. Our benchmark comprises 2,648 test instances spanning four long-context tasks with high IC scores in the domains of books, debates, medicine, and law. Our evaluations reveal significant performance drops in contemporary LLMs, highlighting a critical challenge in managing long contexts. Our benchmark is available at https://github.com/dmis-lab/ETHIC.

Synthesizing clinical evidence largely relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publications presents challenges in efficiently identifying, summarizing, and updating clinical evidence. Here, we introduce TrialMind, a generative artificial intelligence (AI) pipeline for facilitating human-AI collaboration in three crucial tasks for evidence synthesis: study search, screening, and data extraction. To assess its performance, we chose published systematic reviews to build the benchmark dataset, named TrialReviewBench, which contains 100 systematic reviews and the associated 2,220 clinical studies. Our results show that TrialMind excels across all three tasks. In study search, it generates diverse and comprehensive search queries to achieve high recall rates (Ours 0.711-0.834 v.s. Human baseline 0.138-0.232). For study screening, TrialMind surpasses traditional embedding-based methods by 30% to 160%. In data extraction, it outperforms a GPT-4 baseline by 29.6% to 61.5%. We further conducted user studies to confirm its practical utility. Compared to manual efforts, human-AI collaboration using TrialMind yielded a 71.4% recall lift and 44.2% time savings in study screening and a 23.5% accuracy lift and 63.4% time savings in data extraction. Additionally, when comparing synthesized clinical evidence presented in forest plots, medical experts favored TrialMind's outputs over GPT-4's outputs in 62.5% to 100% of cases. These findings show the promise of LLM-based approaches like TrialMind to accelerate clinical evidence synthesis via streamlining study search, screening, and data extraction from medical literature, with exceptional performance improvement when working with human experts.

We introduce MTet, the largest publicly available parallel corpus for English-Vietnamese translation. MTet consists of 4.2M high-quality training sentence pairs and a multi-domain test set refined by the Vietnamese research community. Combining with previous works on English-Vietnamese translation, we grow the existing parallel dataset to 6.2M sentence pairs. We also release the first pretrained model EnViT5 for English and Vietnamese languages. Combining both resources, our model significantly outperforms previous state-of-the-art results by up to 2 points in translation BLEU score, while being 1.6 times smaller.

This paper discusses the methods that we used for our submissions to the WMT 2023 Terminology Shared Task for German-to-English (DE-EN), English-to-Czech (EN-CS), and Chinese-to-English (ZH-EN) language pairs. The task aims to advance machine translation (MT) by challenging participants to develop systems that accurately translate technical terms, ultimately enhancing communication and understanding in specialised domains. To this end, we conduct experiments that utilise large language models (LLMs) for two purposes: generating synthetic bilingual terminology-based data, and post-editing translations generated by an MT model through incorporating pre-approved terms. Our system employs a four-step process: (i) using an LLM to generate bilingual synthetic data based on the provided terminology, (ii) fine-tuning a generic encoder-decoder MT model, with a mix of the terminology-based synthetic data generated in the first step and a randomly sampled portion of the original generic training data, (iii) generating translations with the fine-tuned MT model, and (iv) finally, leveraging an LLM for terminology-constrained automatic post-editing of the translations that do not include the required terms. The results demonstrate the effectiveness of our proposed approach in improving the integration of pre-approved terms into translations. The number of terms incorporated into the translations of the blind dataset increases from an average of 36.67% with the generic model to an average of 72.88% by the end of the process. In other words, successful utilisation of terms nearly doubles across the three language pairs.

Detecting the translation direction of parallel text has applications for machine translation training and evaluation, but also has forensic applications such as resolving plagiarism or forgery allegations. In this work, we explore an unsupervised approach to translation direction detection based on the simple hypothesis that p(translation|original)>p(original|translation), motivated by the well-known simplification effect in translationese or machine-translationese. In experiments with massively multilingual machine translation models across 20 translation directions, we confirm the effectiveness of the approach for high-resource language pairs, achieving document-level accuracies of 82-96% for NMT-produced translations, and 60-81% for human translations, depending on the model used. Code and demo are available at https://github.com/ZurichNLP/translation-direction-detection

We consider the problem of automatically generating a narrative biomedical evidence summary from multiple trial reports. We evaluate modern neural models for abstractive summarization of relevant article abstracts from systematic reviews previously conducted by members of the Cochrane collaboration, using the authors conclusions section of the review abstract as our target. We enlist medical professionals to evaluate generated summaries, and we find that modern summarization systems yield consistently fluent and relevant synopses, but that they are not always factual. We propose new approaches that capitalize on domain-specific models to inform summarization, e.g., by explicitly demarcating snippets of inputs that convey key findings, and emphasizing the reports of large and high-quality trials. We find that these strategies modestly improve the factual accuracy of generated summaries. Finally, we propose a new method for automatically evaluating the factuality of generated narrative evidence syntheses using models that infer the directionality of reported findings.

The increasing use of tools and solutions based on Large Language Models (LLMs) for various tasks in the medical domain has become a prominent trend. Their use in this highly critical and sensitive domain has thus raised important questions about their robustness, especially in response to variations in input, and the reliability of the generated outputs. This study addresses these questions by constructing a textual dataset based on the ICD-10-CM code descriptions, widely used in US hospitals and containing many clinical terms, and their easily reproducible rephrasing. We then benchmarked existing embedding models, either generalist or specialized in the clinical domain, in a semantic search task where the goal was to correctly match the rephrased text to the original description. Our results showed that generalist models performed better than clinical models, suggesting that existing clinical specialized models are more sensitive to small changes in input that confuse them. The highlighted problem of specialized models may be due to the fact that they have not been trained on sufficient data, and in particular on datasets that are not diverse enough to have a reliable global language understanding, which is still necessary for accurate handling of medical documents.

Translate-test is a popular technique to improve the performance of multilingual language models. This approach works by translating the input into English using an external machine translation system, and running inference over the translated input. However, these improvements can be attributed to the use of a separate translation system, which is typically trained on large amounts of parallel data not seen by the language model. In this work, we introduce a new approach called self-translate, which overcomes the need of an external translation system by leveraging the few-shot translation capabilities of multilingual language models. Experiments over 5 tasks show that self-translate consistently outperforms direct inference, demonstrating that language models are unable to leverage their full multilingual potential when prompted in non-English languages. Our code is available at https://github.com/juletx/self-translate.

Large language models (LLMs) have made significant strides in various natural language processing (NLP) tasks. Recent research shows that the moderately-sized LLMs often outperform their larger counterparts after task-specific fine-tuning. In this work, we delve into the process of adapting LLMs to specialize in document-level machine translation (DocMT) for a specific language pair. Firstly, we explore how prompt strategies affect downstream translation performance. Then, we conduct extensive experiments with two fine-tuning methods, three LLM backbones, and 18 translation tasks across nine language pairs. Our findings indicate that in some cases, these specialized models even surpass GPT-4 in translation performance, while they still significantly suffer from the off-target translation issue in others, even if they are exclusively fine-tuned on bilingual parallel documents. Furthermore, we provide an in-depth analysis of these LLMs tailored for DocMT, exploring aspects such as translation errors, discourse phenomena, training strategy, the scaling law of parallel documents, additional evaluation on recent test sets, and zero-shot crosslingual transfer. Our findings not only shed light on the strengths and limitations of LLM-based DocMT models but also provide a foundation for future research.

Background: Dutch medical corpora are scarce, limiting NLP development. \\ Methods: We translated English datasets, identified medical text in generic corpora, and extracted open Dutch medical resources. \\ Results: The resulting corpus comprises pm 35 billion tokens across the medical domain in about 100 million documents, freely available on Hugging Face. \\ Conclusion: This work establishes the first large-scale Dutch medical language corpus for pre-training and downstream NLP tasks.

Background: General-purpose large language models that utilize both text and images have not been evaluated on a diverse array of challenging medical cases. Methods: Using 934 cases from the NEJM Image Challenge published between 2005 and 2023, we evaluated the accuracy of the recently released Generative Pre-trained Transformer 4 with Vision model (GPT-4V) compared to human respondents overall and stratified by question difficulty, image type, and skin tone. We further conducted a physician evaluation of GPT-4V on 69 NEJM clinicopathological conferences (CPCs). Analyses were conducted for models utilizing text alone, images alone, and both text and images. Results: GPT-4V achieved an overall accuracy of 61% (95% CI, 58 to 64%) compared to 49% (95% CI, 49 to 50%) for humans. GPT-4V outperformed humans at all levels of difficulty and disagreement, skin tones, and image types; the exception was radiographic images, where performance was equivalent between GPT-4V and human respondents. Longer, more informative captions were associated with improved performance for GPT-4V but similar performance for human respondents. GPT-4V included the correct diagnosis in its differential for 80% (95% CI, 68 to 88%) of CPCs when using text alone, compared to 58% (95% CI, 45 to 70%) of CPCs when using both images and text. Conclusions: GPT-4V outperformed human respondents on challenging medical cases and was able to synthesize information from both images and text, but performance deteriorated when images were added to highly informative text. Overall, our results suggest that multimodal AI models may be useful in medical diagnostic reasoning but that their accuracy may depend heavily on context.

If you had an AI Whale-to-English translator, how could you validate whether or not it is working? Does one need to interact with the animals or rely on grounded observations such as temperature? We provide theoretical and proof-of-concept experimental evidence suggesting that interaction and even observations may not be necessary for sufficiently complex languages. One may be able to evaluate translators solely by their English outputs, offering potential advantages in terms of safety, ethics, and cost. This is an instance of machine translation quality evaluation (MTQE) without any reference translations available. A key challenge is identifying ``hallucinations,'' false translations which may appear fluent and plausible. We propose using segment-by-segment translation together with the classic NLP shuffle test to evaluate translators. The idea is to translate animal communication, turn by turn, and evaluate how often the resulting translations make more sense in order than permuted. Proof-of-concept experiments on data-scarce human languages and constructed languages demonstrate the potential utility of this evaluation methodology. These human-language experiments serve solely to validate our reference-free metric under data scarcity. It is found to correlate highly with a standard evaluation based on reference translations, which are available in our experiments. We also perform a theoretical analysis suggesting that interaction may not be necessary nor efficient in the early stages of learning to translate.

Research on Machine Translation (MT) has achieved important breakthroughs in several areas. While there is much more to be done in order to build on this success, we believe that the language industry needs better ways to take full advantage of current achievements. Due to a combination of factors, including time, resources, and skills, businesses tend to apply pragmatism into their AI workflows. Hence, they concentrate more on outcomes, e.g. delivery, shipping, releases, and features, and adopt high-level working production solutions, where possible. Among the features thought to be helpful for translators are sentence-level and word-level translation auto-suggestion and auto-completion. Suggesting alternatives can inspire translators and limit their need to refer to external resources, which hopefully boosts their productivity. This work describes our submissions to WMT's shared task on word-level auto-completion, for the Chinese-to-English, English-to-Chinese, German-to-English, and English-to-German language directions. We investigate the possibility of using pre-trained models and out-of-the-box features from available libraries. We employ random sampling to generate diverse alternatives, which reveals good results. Furthermore, we introduce our open-source API, based on CTranslate2, to serve translations, auto-suggestions, and auto-completions.

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and potentially accelerate biomedical discovery. In this paper, we present a comprehensive evaluation of LLMs as biomedical hypothesis generators. We construct a dataset of background-hypothesis pairs from biomedical literature, carefully partitioned into training, seen, and unseen test sets based on publication date to mitigate data contamination. Using this dataset, we assess the hypothesis generation capabilities of top-tier instructed models in zero-shot, few-shot, and fine-tuning settings. To enhance the exploration of uncertainty, a crucial aspect of scientific discovery, we incorporate tool use and multi-agent interactions in our evaluation framework. Furthermore, we propose four novel metrics grounded in extensive literature review to evaluate the quality of generated hypotheses, considering both LLM-based and human assessments. Our experiments yield two key findings: 1) LLMs can generate novel and validated hypotheses, even when tested on literature unseen during training, and 2) Increasing uncertainty through multi-agent interactions and tool use can facilitate diverse candidate generation and improve zero-shot hypothesis generation performance. However, we also observe that the integration of additional knowledge through few-shot learning and tool use may not always lead to performance gains, highlighting the need for careful consideration of the type and scope of external knowledge incorporated. These findings underscore the potential of LLMs as powerful aids in biomedical hypothesis generation and provide valuable insights to guide further research in this area.

Unsupervised domain translation (UDT) aims to find functions that convert samples from one domain (e.g., sketches) to another domain (e.g., photos) without changing the high-level semantic meaning (also referred to as ``content''). The translation functions are often sought by probability distribution matching of the transformed source domain and target domain. CycleGAN stands as arguably the most representative approach among this line of work. However, it was noticed in the literature that CycleGAN and variants could fail to identify the desired translation functions and produce content-misaligned translations. This limitation arises due to the presence of multiple translation functions -- referred to as ``measure-preserving automorphism" (MPA) -- in the solution space of the learning criteria. Despite awareness of such identifiability issues, solutions have remained elusive. This study delves into the core identifiability inquiry and introduces an MPA elimination theory. Our analysis shows that MPA is unlikely to exist, if multiple pairs of diverse cross-domain conditional distributions are matched by the learning function. Our theory leads to a UDT learner using distribution matching over auxiliary variable-induced subsets of the domains -- other than over the entire data domains as in the classical approaches. The proposed framework is the first to rigorously establish translation identifiability under reasonable UDT settings, to our best knowledge. Experiments corroborate with our theoretical claims.

In this paper, we introduce a unified and generalist Biomedical Generative Pre-trained Transformer (BiomedGPT) model, which leverages self-supervision on large and diverse datasets to accept multi-modal inputs and perform a range of downstream tasks. Our experiments demonstrate that BiomedGPT delivers expansive and inclusive representations of biomedical data, outperforming the majority of preceding state-of-the-art models across five distinct tasks with 20 public datasets spanning over 15 unique biomedical modalities. Through the ablation study, we also showcase the efficacy of our multi-modal and multi-task pretraining approach in transferring knowledge to previously unseen data. Overall, our work presents a significant step forward in developing unified and generalist models for biomedicine, with far-reaching implications for improving healthcare outcomes.

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to automate such tasks allows for quick and direct accessibility for lay readers. In this work, we investigate the ability of state-of-the-art large language models (LLMs) on the task of biomedical abstract simplification, using the publicly available dataset for plain language adaptation of biomedical abstracts (PLABA). The methods applied include domain fine-tuning and prompt-based learning (PBL) on: 1) Encoder-decoder models (T5, SciFive, and BART), 2) Decoder-only GPT models (GPT-3.5 and GPT-4) from OpenAI and BioGPT, and 3) Control-token mechanisms on BART-based models. We used a range of automatic evaluation metrics, including BLEU, ROUGE, SARI, and BERTscore, and also conducted human evaluations. BART-Large with Control Token (BART-L-w-CT) mechanisms reported the highest SARI score of 46.54 and T5-base reported the highest BERTscore 72.62. In human evaluation, BART-L-w-CTs achieved a better simplicity score over T5-Base (2.9 vs. 2.2), while T5-Base achieved a better meaning preservation score over BART-L-w-CTs (3.1 vs. 2.6). We also categorised the system outputs with examples, hoping this will shed some light for future research on this task. Our code, fine-tuned models, and data splits are available at https://github.com/HECTA-UoM/PLABA-MU

Developing therapeutics is a lengthy and expensive process that requires the satisfaction of many different criteria, and AI models capable of expediting the process would be invaluable. However, the majority of current AI approaches address only a narrowly defined set of tasks, often circumscribed within a particular domain. To bridge this gap, we introduce Tx-LLM, a generalist large language model (LLM) fine-tuned from PaLM-2 which encodes knowledge about diverse therapeutic modalities. Tx-LLM is trained using a collection of 709 datasets that target 66 tasks spanning various stages of the drug discovery pipeline. Using a single set of weights, Tx-LLM simultaneously processes a wide variety of chemical or biological entities(small molecules, proteins, nucleic acids, cell lines, diseases) interleaved with free-text, allowing it to predict a broad range of associated properties, achieving competitive with state-of-the-art (SOTA) performance on 43 out of 66 tasks and exceeding SOTA on 22. Among these, Tx-LLM is particularly powerful and exceeds best-in-class performance on average for tasks combining molecular SMILES representations with text such as cell line names or disease names, likely due to context learned during pretraining. We observe evidence of positive transfer between tasks with diverse drug types (e.g.,tasks involving small molecules and tasks involving proteins), and we study the impact of model size, domain finetuning, and prompting strategies on performance. We believe Tx-LLM represents an important step towards LLMs encoding biochemical knowledge and could have a future role as an end-to-end tool across the drug discovery development pipeline.

Generating a review for an academic research paper is a complex task that requires a deep understanding of the document's content and the interdependencies between its sections. It demands not only insight into technical details but also an appreciation of the paper's overall coherence and structure. Recent methods have predominantly focused on fine-tuning large language models (LLMs) to address this challenge. However, they often overlook the computational and performance limitations imposed by long input token lengths. To address this, we introduce AutoRev, an Automatic Peer Review System for Academic Research Papers. Our novel framework represents an academic document as a graph, enabling the extraction of the most critical passages that contribute significantly to the review. This graph-based approach demonstrates effectiveness for review generation and is potentially adaptable to various downstream tasks, such as question answering, summarization, and document representation. When applied to review generation, our method outperforms SOTA baselines by an average of 58.72% across all evaluation metrics. We hope that our work will stimulate further research in applying graph-based extraction techniques to other downstream tasks in NLP. We plan to make our code public upon acceptance.

Systematic literature reviews (SLRs) play an essential role in summarising, synthesising and validating scientific evidence. In recent years, there has been a growing interest in using machine learning techniques to automate the identification of relevant studies for SLRs. However, the lack of standardised evaluation datasets makes comparing the performance of such automated literature screening systems difficult. In this paper, we analyse the citation screening evaluation datasets, revealing that many of the available datasets are either too small, suffer from data leakage or have limited applicability to systems treating automated literature screening as a classification task, as opposed to, for example, a retrieval or question-answering task. To address these challenges, we introduce CSMeD, a meta-dataset consolidating nine publicly released collections, providing unified access to 325 SLRs from the fields of medicine and computer science. CSMeD serves as a comprehensive resource for training and evaluating the performance of automated citation screening models. Additionally, we introduce CSMeD-FT, a new dataset designed explicitly for evaluating the full text publication screening task. To demonstrate the utility of CSMeD, we conduct experiments and establish baselines on new datasets.

The increasing adoption of large language models (LLMs) has been accompanied by growing concerns regarding their reliability and trustworthiness. As a result, a growing body of research focuses on evidence-based text generation with LLMs, aiming to link model outputs to supporting evidence to ensure traceability and verifiability. However, the field is fragmented due to inconsistent terminology, isolated evaluation practices, and a lack of unified benchmarks. To bridge this gap, we systematically analyze 134 papers, introduce a unified taxonomy of evidence-based text generation with LLMs, and investigate 300 evaluation metrics across seven key dimensions. Thereby, we focus on approaches that use citations, attribution, or quotations for evidence-based text generation. Building on this, we examine the distinctive characteristics and representative methods in the field. Finally, we highlight open challenges and outline promising directions for future work.

Hospitals and healthcare systems rely on operational decisions that determine patient flow, cost, and quality of care. Despite strong performance on medical knowledge and conversational benchmarks, foundation models trained on general text may lack the specialized knowledge required for these operational decisions. We introduce Lang1, a family of models (100M-7B parameters) pretrained on a specialized corpus blending 80B clinical tokens from NYU Langone Health's EHRs and 627B tokens from the internet. To rigorously evaluate Lang1 in real-world settings, we developed the REalistic Medical Evaluation (ReMedE), a benchmark derived from 668,331 EHR notes that evaluates five critical tasks: 30-day readmission prediction, 30-day mortality prediction, length of stay, comorbidity coding, and predicting insurance claims denial. In zero-shot settings, both general-purpose and specialized models underperform on four of five tasks (36.6%-71.7% AUROC), with mortality prediction being an exception. After finetuning, Lang1-1B outperforms finetuned generalist models up to 70x larger and zero-shot models up to 671x larger, improving AUROC by 3.64%-6.75% and 1.66%-23.66% respectively. We also observed cross-task scaling with joint finetuning on multiple tasks leading to improvement on other tasks. Lang1-1B effectively transfers to out-of-distribution settings, including other clinical tasks and an external health system. Our findings suggest that predictive capabilities for hospital operations require explicit supervised finetuning, and that this finetuning process is made more efficient by in-domain pretraining on EHR. Our findings support the emerging view that specialized LLMs can compete with generalist models in specialized tasks, and show that effective healthcare systems AI requires the combination of in-domain pretraining, supervised finetuning, and real-world evaluation beyond proxy benchmarks.

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating biomedical claims remains uniquely challenging due to complex terminology, the need for domain expertise, and the critical importance of grounding in scientific evidence. We introduce CER (Combining Evidence and Reasoning), a novel framework for biomedical fact-checking that integrates scientific evidence retrieval, reasoning via large language models, and supervised veracity prediction. By integrating the text-generation capabilities of large language models with advanced retrieval techniques for high-quality biomedical scientific evidence, CER effectively mitigates the risk of hallucinations, ensuring that generated outputs are grounded in verifiable, evidence-based sources. Evaluations on expert-annotated datasets (HealthFC, BioASQ-7b, SciFact) demonstrate state-of-the-art performance and promising cross-dataset generalization. Code and data are released for transparency and reproducibility: https://github.com/PRAISELab-PicusLab/CER

Keyphrase generation is the task consisting in generating a set of words or phrases that highlight the main topics of a document. There are few datasets for keyphrase generation in the biomedical domain and they do not meet the expectations in terms of size for training generative models. In this paper, we introduce kp-biomed, the first large-scale biomedical keyphrase generation dataset with more than 5M documents collected from PubMed abstracts. We train and release several generative models and conduct a series of experiments showing that using large scale datasets improves significantly the performances for present and absent keyphrase generation. The dataset is available under CC-BY-NC v4.0 license at https://huggingface.co/ datasets/taln-ls2n/kpbiomed.

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers have developed foundation models for individual scientific domains, including small molecules, materials, proteins, DNA, and RNA. However, these models are typically trained in isolation, lacking the ability to integrate across different scientific domains. Recognizing that entities within these domains can all be represented as sequences, which together form the "language of nature", we introduce Nature Language Model (briefly, NatureLM), a sequence-based science foundation model designed for scientific discovery. Pre-trained with data from multiple scientific domains, NatureLM offers a unified, versatile model that enables various applications including: (i) generating and optimizing small molecules, proteins, RNA, and materials using text instructions; (ii) cross-domain generation/design, such as protein-to-molecule and protein-to-RNA generation; and (iii) achieving state-of-the-art performance in tasks like SMILES-to-IUPAC translation and retrosynthesis on USPTO-50k. NatureLM offers a promising generalist approach for various scientific tasks, including drug discovery (hit generation/optimization, ADMET optimization, synthesis), novel material design, and the development of therapeutic proteins or nucleotides. We have developed NatureLM models in different sizes (1 billion, 8 billion, and 46.7 billion parameters) and observed a clear improvement in performance as the model size increases.

Large Language Models (LLMs) have demonstrated strong capabilities in multilingual machine translation, sometimes even outperforming traditional neural systems. However, previous research has highlighted the challenges of using LLMs, particularly with prompt engineering, for low-resource languages. In this work, we introduce Fragment-Shot Prompting, a novel in-context learning method that segments input and retrieves translation examples based on syntactic coverage, along with Pivoted Fragment-Shot, an extension that enables translation without direct parallel data. We evaluate these methods using GPT-3.5, GPT-4o, o1-mini, LLaMA-3.3, and DeepSeek-R1 for translation between Italian and two Ladin variants, revealing three key findings: (1) Fragment-Shot Prompting is effective for translating into and between the studied low-resource languages, with syntactic coverage positively correlating with translation quality; (2) Models with stronger reasoning abilities make more effective use of retrieved knowledge, generally produce better translations, and enable Pivoted Fragment-Shot to significantly improve translation quality between the Ladin variants; and (3) prompt engineering offers limited, if any, improvements when translating from a low-resource to a high-resource language, where zero-shot prompting already yields satisfactory results. We publicly release our code and the retrieval corpora.

We present ASCAT (Arabic Scientific Corpus for Advanced Translation), a high-quality English-Arabic parallel benchmark corpus designed for scientific translation evaluation constructed through a systematic multi-engine translation and human validation pipeline. Unlike existing Arabic-English corpora that rely on short sentences or single-domain text, ASCAT targets full scientific abstracts averaging 141.7 words (English) and 111.78 words (Arabic), drawn from five scientific domains: physics, mathematics, computer science, quantum mechanics, and artificial intelligence. Each abstract was translated using three complementary architectures generative AI (Gemini), transformer-based models (Hugging Face quickmt-en-ar), and commercial MT APIs (Google Translate, DeepL) and subsequently validated by domain experts at the lexical, syntactic, and semantic levels. The resulting corpus contains 67,293 English tokens and 60,026 Arabic tokens, with an Arabic vocabulary of 17,604 unique words reflecting the morphological richness of the language. We benchmark three state-of-the-art LLMs on the corpus GPT-4o-mini (BLEU: 37.07), Gemini-3.0-Flash-Preview (BLEU: 30.44), and Qwen3-235B-A22B (BLEU: 23.68) demonstrating its discriminative power as an evaluation benchmark. ASCAT addresses a critical gap in scientific MT resources for Arabic and is designed to support rigorous evaluation of scientific translation quality and training of domain-specific translation models.

While general-purpose large language models (LLMs) demonstrate proficiency on multiple tasks within the domain of translation, approaches based on open LLMs are competitive only when specializing on a single task. In this paper, we propose a recipe for tailoring LLMs to multiple tasks present in translation workflows. We perform continued pretraining on a multilingual mixture of monolingual and parallel data, creating TowerBase, followed by finetuning on instructions relevant for translation processes, creating TowerInstruct. Our final model surpasses open alternatives on several tasks relevant to translation workflows and is competitive with general-purpose closed LLMs. To facilitate future research, we release the Tower models, our specialization dataset, an evaluation framework for LLMs focusing on the translation ecosystem, and a collection of model generations, including ours, on our benchmark.

The development of vision-language models (VLMs) is driven by large-scale and diverse multimodal datasets. However, progress toward generalist biomedical VLMs is limited by the lack of annotated, publicly accessible datasets across biology and medicine. Existing efforts are restricted to narrow domains, missing the full diversity of biomedical knowledge encoded in scientific literature. To address this gap, we introduce BIOMEDICA, a scalable, open-source framework to extract, annotate, and serialize the entirety of the PubMed Central Open Access subset into an easy-to-use, publicly accessible dataset.Our framework produces a comprehensive archive with over 24 million unique image-text pairs from over 6 million articles. Metadata and expert-guided annotations are also provided. We demonstrate the utility and accessibility of our resource by releasing BMCA-CLIP, a suite of CLIP-style models continuously pre-trained on the BIOMEDICA dataset via streaming, eliminating the need to download 27 TB of data locally.On average, our models achieve state-of-the-art performance across 40 tasks - spanning pathology, radiology, ophthalmology, dermatology, surgery, molecular biology, parasitology, and cell biology - excelling in zero-shot classification with a 6.56% average improvement (as high as 29.8% and 17.5% in dermatology and ophthalmology, respectively), and stronger image-text retrieval, all while using 10x less compute. To foster reproducibility and collaboration, we release our codebase and dataset for the broader research community.

Code coverage is a widely used metric for quantifying the extent to which program elements, such as statements or branches, are executed during testing. Calculating code coverage is resource-intensive, requiring code building and execution with additional overhead for the instrumentation. Furthermore, computing coverage of any snippet of code requires the whole program context. Using Machine Learning to amortize this expensive process could lower the cost of code coverage by requiring only the source code context, and the task of code coverage prediction can be a novel benchmark for judging the ability of models to understand code. We propose a novel benchmark task called Code Coverage Prediction for Large Language Models (LLMs). We formalize this task to evaluate the capability of LLMs in understanding code execution by determining which lines of a method are executed by a given test case and inputs. We curate and release a dataset we call COVERAGEEVAL by executing tests and code from the HumanEval dataset and collecting code coverage information. We report the performance of four state-of-the-art LLMs used for code-related tasks, including OpenAI's GPT-4 and GPT-3.5-Turbo, Google's BARD, and Anthropic's Claude, on the Code Coverage Prediction task. Finally, we argue that code coverage as a metric and pre-training data source are valuable for overall LLM performance on software engineering tasks.

Testing is an integral part of the software development process. Yet, writing tests is time-consuming and therefore often neglected. Classical test generation tools such as EvoSuite generate behavioral test suites by optimizing for coverage, but tend to produce tests that are hard to understand. Language models trained on code can generate code that is highly similar to that written by humans, but current models are trained to generate each file separately, as is standard practice in natural language processing, and thus fail to consider the code-under-test context when producing a test file. In this work, we propose the Aligned Code And Tests Language Model (CAT-LM), a GPT-style language model with 2.7 Billion parameters, trained on a corpus of Python and Java projects. We utilize a novel pretraining signal that explicitly considers the mapping between code and test files when available. We also drastically increase the maximum sequence length of inputs to 8,192 tokens, 4x more than typical code generation models, to ensure that the code context is available to the model when generating test code. We analyze its usefulness for realistic applications, showing that sampling with filtering (e.g., by compilability, coverage) allows it to efficiently produce tests that achieve coverage similar to ones written by developers while resembling their writing style. By utilizing the code context, CAT-LM generates more valid tests than even much larger language models trained with more data (CodeGen 16B and StarCoder) and substantially outperforms a recent test-specific model (TeCo) at test completion. Overall, our work highlights the importance of incorporating software-specific insights when training language models for code and paves the way to more powerful automated test generation.

High-quality machine translation (MT) can scale to hundreds of languages, setting a high bar for multilingual systems. However, compared to the world's 7,000 languages, current systems still offer only limited coverage: about 200 languages on the target side, and maybe a few hundreds more on the source side, supported due to cross-lingual transfer. And even these numbers have been hard to evaluate due to the lack of reliable benchmarks and metrics. We present Omnilingual Machine Translation (OMT), the first MT system supporting more than 1,600 languages. This scale is enabled by a comprehensive data strategy that integrates large public multilingual corpora with newly created datasets, including manually curated MeDLEY bitext. We explore two ways of specializing a Large Language model (LLM) for machine translation: as a decoder-only model (OMT-LLaMA) or as a module in an encoder-decoder architecture (OMT-NLLB). Notably, all our 1B to 8B parameter models match or exceed the MT performance of a 70B LLM baseline, revealing a clear specialization advantage and enabling strong translation quality in low-compute settings. Moreover, our evaluation of English-to-1,600 translations further shows that while baseline models can interpret undersupported languages, they frequently fail to generate them with meaningful fidelity; OMT-LLaMA models substantially expand the set of languages for which coherent generation is feasible. Additionally, OMT models improve in cross-lingual transfer, being close to solving the "understanding" part of the puzzle in MT for the 1,600 evaluated. Our leaderboard and main human-created evaluation datasets (BOUQuET and Met-BOUQuET) are dynamically evolving towards Omnilinguality and freely available.

As generic machine translation (MT) quality has improved, the need for targeted benchmarks that explore fine-grained aspects of quality has increased. In particular, gender accuracy in translation can have implications in terms of output fluency, translation accuracy, and ethics. In this paper, we introduce MT-GenEval, a benchmark for evaluating gender accuracy in translation from English into eight widely-spoken languages. MT-GenEval complements existing benchmarks by providing realistic, gender-balanced, counterfactual data in eight language pairs where the gender of individuals is unambiguous in the input segment, including multi-sentence segments requiring inter-sentential gender agreement. Our data and code is publicly available under a CC BY SA 3.0 license.

Research on language technology for the development of medical applications is currently a hot topic in Natural Language Understanding and Generation. Thus, a number of large language models (LLMs) have recently been adapted to the medical domain, so that they can be used as a tool for mediating in human-AI interaction. While these LLMs display competitive performance on automated medical texts benchmarks, they have been pre-trained and evaluated with a focus on a single language (English mostly). This is particularly true of text-to-text models, which typically require large amounts of domain-specific pre-training data, often not easily accessible for many languages. In this paper, we address these shortcomings by compiling, to the best of our knowledge, the largest multilingual corpus for the medical domain in four languages, namely English, French, Italian and Spanish. This new corpus has been used to train Medical mT5, the first open-source text-to-text multilingual model for the medical domain. Additionally, we present two new evaluation benchmarks for all four languages with the aim of facilitating multilingual research in this domain. A comprehensive evaluation shows that Medical mT5 outperforms both encoders and similarly sized text-to-text models for the Spanish, French, and Italian benchmarks, while being competitive with current state-of-the-art LLMs in English.

Existing approaches to multilingual text detoxification are hampered by the scarcity of parallel multilingual datasets. In this work, we introduce a pipeline for the generation of multilingual parallel detoxification data. We also introduce SynthDetoxM, a manually collected and synthetically generated multilingual parallel text detoxification dataset comprising 16,000 high-quality detoxification sentence pairs across German, French, Spanish and Russian. The data was sourced from different toxicity evaluation datasets and then rewritten with nine modern open-source LLMs in few-shot setting. Our experiments demonstrate that models trained on the produced synthetic datasets have superior performance to those trained on the human-annotated MultiParaDetox dataset even in data limited setting. Models trained on SynthDetoxM outperform all evaluated LLMs in few-shot setting. We release our dataset and code to help further research in multilingual text detoxification.

We survey clinical document corpora, with focus on German textual data. Due to rigid data privacy legislation in Germany these resources, with only few exceptions, are stored in safe clinical data spaces and locked against clinic-external researchers. This situation stands in stark contrast with established workflows in the field of natural language processing where easy accessibility and reuse of data collections are common practice. Hence, alternative corpus designs have been examined to escape from this data poverty. Besides machine translation of English clinical datasets and the generation of synthetic corpora with fictitious clinical contents, several other types of domain proxies have come up as substitutes for authentic clinical documents. Common instances of close proxies are medical journal publications, clinical therapy guidelines, drug labels, etc., more distant proxies include online encyclopedic medical articles or medical contents from social media channels. After PRISM-conformant screening of 359 hits from four bibliographic systems, 75 relevant documents were finally selected for this review and 59 distinct corpora were determined. We identified 24 real clinical corpora (from 40 publications) out of which only 5 are publicly distributable. 2 translations of real corpora and 3 synthetic ones complement the set of clinical corpora. 14 corpora were categorized as close domain proxies, 16 as distant ones. There is a clear divide between the large number of non-accessible authentic clinical German-language corpora and their publicly accessible substitutes: translated or synthetic, close or more distant proxies. So on first sight, the data bottleneck seems broken. Intuitively yet, differences in genre-specific writing style, wording and medical domain expertise in this typological space are also obvious. This raises the question how valid alternative corpus designs really are.

In many scientific fields, large language models (LLMs) have revolutionized the way text and other modalities of data (e.g., molecules and proteins) are handled, achieving superior performance in various applications and augmenting the scientific discovery process. Nevertheless, previous surveys on scientific LLMs often concentrate on one or two fields or a single modality. In this paper, we aim to provide a more holistic view of the research landscape by unveiling cross-field and cross-modal connections between scientific LLMs regarding their architectures and pre-training techniques. To this end, we comprehensively survey over 260 scientific LLMs, discuss their commonalities and differences, as well as summarize pre-training datasets and evaluation tasks for each field and modality. Moreover, we investigate how LLMs have been deployed to benefit scientific discovery. Resources related to this survey are available at https://github.com/yuzhimanhua/Awesome-Scientific-Language-Models.

Recent advances in generative models, including large language models (LLMs), vision language models (VLMs), and diffusion models, have accelerated the field of natural language and image processing in medicine and marked a significant paradigm shift in how biomedical models can be developed and deployed. While these models are highly adaptable to new tasks, scaling and evaluating their usage presents new challenges not addressed in previous frameworks. In particular, the ability of these models to produce useful outputs with little to no specialized training data ("zero-" or "few-shot" approaches), as well as the open-ended nature of their outputs, necessitate the development of new guidelines for robust reporting of clinical generative model research. In response to gaps in standards and best practices for the development of clinical AI tools identified by US Executive Order 141103 and several emerging national networks for clinical AI evaluation, we begin to formalize some of these guidelines by building on the original MI-CLAIM checklist. The new checklist, MI-CLAIM-GEN (Table 1), aims to address differences in training, evaluation, interpretability, and reproducibility of new generative models compared to non-generative ("predictive") AI models. This MI-CLAIM-GEN checklist also seeks to clarify cohort selection reporting with unstructured clinical data and adds additional items on alignment with ethical standards for clinical AI research.

Software testing is a critical, yet resource-intensive phase of the software development lifecycle. Over the years, various automated tools have been developed to aid in this process. Search-based approaches typically achieve high coverage but produce tests with low readability, whereas large language model (LLM)-based methods generate more human-readable tests but often suffer from low coverage and compilability. While the majority of research efforts have focused on improving test coverage and readability, little attention has been paid to enhancing the robustness of bug detection, particularly in exposing corner cases and vulnerable execution paths. To address this gap, we propose AdverTest, a novel adversarial framework for LLM-powered test case generation. AdverTest comprises two interacting agents: a test case generation agent (T) and a mutant generation agent (M). These agents engage in an adversarial loop, where M persistently creates new mutants "hacking" the blind spots of T's current test suite, while T iteratively refines its test cases to "kill" the challenging mutants produced by M. This interaction loop is guided by both coverage and mutation scores, enabling the system to co-evolve toward both high test coverage and bug detection capability. Experimental results in the Defects4J dataset show that our approach improves fault detection rates by 8.56% over the best existing LLM-based methods and by 63.30% over EvoSuite, while also improving line and branch coverage.

Recent advancements in Large Language Models (LLMs) have significantly improved text generation capabilities. However, they also present challenges, particularly in generating vaccine-related misinformation, which poses risks to public health. Despite research on human-authored misinformation, a notable gap remains in understanding how LLMs contribute to vaccine misinformation and how best to detect it. Existing benchmarks often overlook vaccine-specific misinformation and the diverse roles of misinformation spreaders. This paper introduces VaxGuard, a novel dataset designed to address these challenges. VaxGuard includes vaccine-related misinformation generated by multiple LLMs and provides a comprehensive framework for detecting misinformation across various roles. Our findings show that GPT-3.5 and GPT-4o consistently outperform other LLMs in detecting misinformation, especially when dealing with subtle or emotionally charged narratives. On the other hand, PHI3 and Mistral show lower performance, struggling with precision and recall in fear-driven contexts. Additionally, detection performance tends to decline as input text length increases, indicating the need for improved methods to handle larger content. These results highlight the importance of role-specific detection strategies and suggest that VaxGuard can serve as a key resource for improving the detection of LLM-generated vaccine misinformation.

Infodemics and health misinformation have significant negative impact on individuals and society, exacerbating confusion and increasing hesitancy in adopting recommended health measures. Recent advancements in generative AI, capable of producing realistic, human like text and images, have significantly accelerated the spread and expanded the reach of health misinformation, resulting in an alarming surge in its dissemination. To combat the infodemics, most existing work has focused on developing misinformation datasets from social media and fact checking platforms, but has faced limitations in topical coverage, inclusion of AI generation, and accessibility of raw content. To address these issues, we present MM Health, a large scale multimodal misinformation dataset in the health domain consisting of 34,746 news article encompassing both textual and visual information. MM Health includes human-generated multimodal information (5,776 articles) and AI generated multimodal information (28,880 articles) from various SOTA generative AI models. Additionally, We benchmarked our dataset against three tasks (reliability checks, originality checks, and fine-grained AI detection) demonstrating that existing SOTA models struggle to accurately distinguish the reliability and origin of information. Our dataset aims to support the development of misinformation detection across various health scenarios, facilitating the detection of human and machine generated content at multimodal levels.

Large Language Models (LLMs) have shown remarkable performance across various tasks, yet significant disparities remain for non-English languages, and especially native African languages. This paper addresses these disparities by creating approximately 1 million human-translated words of new benchmark data in 8 low-resource African languages, covering a population of over 160 million speakers of: Amharic, Bambara, Igbo, Sepedi (Northern Sotho), Shona, Sesotho (Southern Sotho), Setswana, and Tsonga. Our benchmarks are translations of Winogrande and three sections of MMLU: college medicine, clinical knowledge, and virology. Using the translated benchmarks, we report previously unknown performance gaps between state-of-the-art (SOTA) LLMs in English and African languages. Finally, using results from over 400 fine-tuned models, we explore several methods to reduce the LLM performance gap, including high-quality dataset fine-tuning (using an LLM-as-an-Annotator), cross-lingual transfer, and cultural appropriateness adjustments. Key findings include average mono-lingual improvements of 5.6% with fine-tuning (with 5.4% average mono-lingual improvements when using high-quality data over low-quality data), 2.9% average gains from cross-lingual transfer, and a 3.0% out-of-the-box performance boost on culturally appropriate questions. The publicly available benchmarks, translations, and code from this study support further research and development aimed at creating more inclusive and effective language technologies.

Recent work has shown that large language models (LLMs) are capable of generating summaries zero-shot (i.e., without explicit supervision) that, under human assessment, are often comparable or even preferred to manually composed reference summaries. However, this prior work has focussed almost exclusively on evaluating news article summarization. How do zero-shot summarizers perform in other (potentially more specialized) domains? In this work we evaluate zero-shot generated summaries across specialized domains including biomedical articles, and legal bills (in addition to standard news benchmarks for reference). We focus especially on the factuality of outputs. We acquire annotations from domain experts to identify inconsistencies in summaries and systematically categorize these errors. We analyze whether the prevalence of a given domain in the pretraining corpus affects extractiveness and faithfulness of generated summaries of articles in this domain. We release all collected annotations to facilitate additional research toward measuring and realizing factually accurate summarization, beyond news articles. The dataset can be downloaded from https://github.com/sanjanaramprasad/zero_shot_faceval_domains

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating biomedical claims remains uniquely challenging due to complex terminology, the need for domain expertise, and the critical importance of grounding in scientific evidence. We introduce CER (Combining Evidence and Reasoning), a novel framework for biomedical fact-checking that integrates scientific evidence retrieval, reasoning via large language models, and supervised veracity prediction. By integrating the text-generation capabilities of large language models with advanced retrieval techniques for high-quality biomedical scientific evidence, CER effectively mitigates the risk of hallucinations, ensuring that generated outputs are grounded in verifiable, evidence-based sources. Evaluations on expert-annotated datasets (HealthFC, BioASQ-7b, SciFact) demonstrate state-of-the-art performance and promising cross-dataset generalization. Code and data are released for transparency and reproducibility: https: //github.com/PRAISELab-PicusLab/CER.

Gender-neutral translation (GNT) that avoids biased and undue binary assumptions is a pivotal challenge for the creation of more inclusive translation technologies. Advancements for this task in Machine Translation (MT), however, are hindered by the lack of dedicated parallel data, which are necessary to adapt MT systems to satisfy neutral constraints. For such a scenario, large language models offer hitherto unforeseen possibilities, as they come with the distinct advantage of being versatile in various (sub)tasks when provided with explicit instructions. In this paper, we explore this potential to automate GNT by comparing MT with the popular GPT-4 model. Through extensive manual analyses, our study empirically reveals the inherent limitations of current MT systems in generating GNTs and provides valuable insights into the potential and challenges associated with prompting for neutrality.

We introduce DivEMT, the first publicly available post-editing study of Neural Machine Translation (NMT) over a typologically diverse set of target languages. Using a strictly controlled setup, 18 professional translators were instructed to translate or post-edit the same set of English documents into Arabic, Dutch, Italian, Turkish, Ukrainian, and Vietnamese. During the process, their edits, keystrokes, editing times and pauses were recorded, enabling an in-depth, cross-lingual evaluation of NMT quality and post-editing effectiveness. Using this new dataset, we assess the impact of two state-of-the-art NMT systems, Google Translate and the multilingual mBART-50 model, on translation productivity. We find that post-editing is consistently faster than translation from scratch. However, the magnitude of productivity gains varies widely across systems and languages, highlighting major disparities in post-editing effectiveness for languages at different degrees of typological relatedness to English, even when controlling for system architecture and training data size. We publicly release the complete dataset including all collected behavioral data, to foster new research on the translation capabilities of NMT systems for typologically diverse languages.