popV/tabula_muris_All_10x

Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.

Model description

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.

Training Code URL: Not provided by uploader.

Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.

Cell Type	N cells	celltypist	knn bbknn	knn harmony	knn on scvi	onclass	scanvi	svm	xgboost	Consensus Prediction
B cell	3036	0.94	0.93	0.90	0.93	0.00	0.90	0.87	0.88	0.94
mesenchymal stem cell	1421	0.90	0.83	0.96	0.88	0.00	0.81	0.94	0.90	0.96
granulocyte	1201	0.86	0.88	0.85	0.87	0.00	0.88	0.79	0.84	0.89
basal cell of epidermis	1122	0.90	0.90	0.90	0.93	0.00	0.82	0.89	0.86	0.94
T cell	1155	0.85	0.81	0.77	0.79	0.00	0.79	0.74	0.79	0.87
keratinocyte	1117	0.91	0.85	0.92	0.94	0.00	0.86	0.91	0.87	0.95
endothelial cell	964	0.91	0.93	0.86	0.91	0.00	0.86	0.96	0.92	0.96
classical monocyte	815	0.84	0.53	0.74	0.70	0.00	0.44	0.83	0.84	0.91
granulocytopoietic cell	803	0.81	0.78	0.86	0.86	0.00	0.82	0.77	0.82	0.88
macrophage	773	0.69	0.67	0.66	0.68	0.00	0.58	0.68	0.70	0.78
bladder urothelial cell	519	0.99	1.00	0.97	0.96	0.00	0.95	1.00	0.99	1.00
proerythroblast	491	0.68	0.71	0.68	0.64	0.00	0.69	0.63	0.69	0.76
kidney proximal convoluted tubule epithelial cell	443	0.86	0.87	0.83	0.83	0.00	0.84	0.89	0.89	0.88
endothelial cell of coronary artery	329	0.84	0.86	0.71	0.83	0.00	0.83	0.95	0.91	0.94
epithelial cell of proximal tubule	327	0.81	0.84	0.75	0.75	0.00	0.78	0.85	0.85	0.83
bladder cell	292	0.96	0.96	0.97	0.87	0.00	0.79	0.98	0.96	0.98
mature NK T cell	284	0.67	0.70	0.56	0.58	0.00	0.62	0.64	0.68	0.74
hepatocyte	288	1.00	0.99	0.99	0.99	0.00	0.98	1.00	0.99	1.00
erythroblast	272	0.69	0.71	0.72	0.77	0.00	0.72	0.70	0.75	0.78
promonocyte	286	0.83	0.74	0.78	0.74	0.00	0.66	0.84	0.84	0.88
stromal cell	267	0.72	0.31	0.91	0.63	0.00	0.69	0.93	0.82	0.92
megakaryocyte-erythroid progenitor cell	287	0.70	0.72	0.61	0.78	0.00	0.71	0.70	0.70	0.77
type B pancreatic cell	260	0.95	0.94	0.85	0.99	0.00	0.98	1.00	0.99	0.99
Kupffer cell	242	0.98	0.60	0.79	0.78	0.00	0.81	0.98	0.97	0.98
natural killer cell	270	0.82	0.83	0.74	0.81	0.00	0.75	0.86	0.87	0.85
professional antigen presenting cell	255	0.00	0.00	0.10	0.02	0.00	0.01	0.53	0.47	0.05
fibroblast of cardiac tissue	240	0.98	0.97	0.91	0.74	0.00	0.84	0.99	0.96	1.00
monocyte	231	0.66	0.47	0.73	0.53	0.00	0.45	0.84	0.81	0.85
bronchial smooth muscle cell	213	0.95	0.97	0.91	0.93	0.00	0.97	0.98	0.96	0.97
hematopoietic precursor cell	226	0.63	0.72	0.54	0.61	0.00	0.53	0.74	0.84	0.76
pancreatic acinar cell	214	0.99	0.99	0.66	1.00	0.00	1.00	1.00	1.00	1.00
skeletal muscle satellite cell	199	0.98	0.98	0.97	0.98	0.00	0.98	0.97	0.95	0.98
DN4 thymocyte	181	0.36	0.06	0.45	0.20	0.00	0.15	0.63	0.60	0.42
luminal epithelial cell of mammary gland	191	0.92	0.94	0.97	0.90	0.00	0.82	0.95	0.94	0.98
mesenchymal stem cell of adipose tissue	200	0.57	0.44	0.72	0.57	0.00	0.35	0.89	0.74	0.88
thymocyte	174	0.98	0.16	0.88	0.98	0.00	0.94	0.97	0.97	0.99
myeloid cell	182	0.52	0.14	0.49	0.51	0.00	0.23	0.80	0.75	0.70
fibroblast	182	0.63	0.09	0.73	0.71	0.00	0.55	0.70	0.70	0.76
immature T cell	196	0.94	0.69	0.90	0.97	0.00	0.95	0.95	0.94	0.96
intermediate monocyte	151	0.57	0.28	0.58	0.60	0.00	0.59	0.52	0.61	0.74
epidermal cell	198	0.94	0.00	0.93	0.92	0.00	0.94	0.93	0.91	0.97
chondrocyte	170	0.84	0.00	0.87	0.86	0.00	0.82	0.86	0.86	0.88
plasma cell	159	0.62	0.63	0.62	0.60	0.00	0.59	0.61	0.58	0.73
smooth muscle cell	171	0.75	0.85	0.77	0.83	0.00	0.84	0.92	0.85	0.84
lymphocyte	168	0.17	0.23	0.17	0.19	0.00	0.12	0.31	0.39	0.38
basal cell	181	0.99	0.98	0.99	0.96	0.00	0.95	0.98	0.97	0.99
naive T cell	174	0.84	0.90	0.85	0.90	0.00	0.81	0.88	0.88	0.91
kidney loop of Henle thick ascending limb epithelial cell	150	0.90	0.90	0.87	0.91	0.00	0.90	0.89	0.91	0.91
fibroblast of lung	158	0.94	0.91	0.94	0.94	0.00	0.94	0.96	0.94	0.96
leukocyte	152	0.65	0.57	0.50	0.39	0.00	0.32	0.80	0.73	0.77
alveolar macrophage	136	0.98	0.96	0.98	0.97	0.00	0.96	0.97	0.94	0.99
lung macrophage	117	0.89	0.07	0.67	0.21	0.00	0.78	0.87	0.86	0.95
enterocyte of epithelium of large intestine	93	0.93	0.52	0.82	0.95	0.00	0.94	0.97	0.95	0.96
fenestrated endothelial cell	105	0.85	0.88	0.81	0.81	0.00	0.73	0.93	0.90	0.94
non-classical monocyte	97	0.72	0.80	0.81	0.71	0.00	0.72	0.76	0.78	0.76
double negative thymocyte	98	0.76	0.00	0.39	0.79	0.00	0.86	0.86	0.83	0.85
precursor B cell	102	0.81	0.90	0.80	0.86	0.00	0.85	0.89	0.91	0.89
mesenchymal cell	85	0.24	0.00	0.11	0.12	0.00	0.11	0.38	0.48	0.32
CD8-positive, alpha-beta T cell	89	0.57	0.56	0.17	0.23	0.00	0.38	0.61	0.67	0.66
immature B cell	75	0.95	0.92	0.95	0.97	0.00	0.93	0.64	0.89	0.94
kidney collecting duct principal cell	83	0.93	0.96	0.92	0.98	0.00	0.96	0.96	0.93	0.98
kidney distal convoluted tubule epithelial cell	93	0.93	0.96	0.87	0.96	0.00	0.95	0.92	0.92	0.96
endocardial cell	61	0.89	0.91	0.90	0.88	0.00	0.88	0.92	0.80	0.94
endothelial cell of hepatic sinusoid	71	0.96	0.94	0.85	0.90	0.00	0.81	0.97	0.94	0.98
neutrophil	40	0.59	0.54	0.35	0.56	0.00	0.67	0.78	0.72	0.79
CD4-positive, alpha-beta T cell	39	0.30	0.42	0.05	0.17	0.00	0.37	0.42	0.35	0.56
late pro-B cell	52	0.78	0.72	0.40	0.67	0.00	0.76	0.82	0.77	0.90
adventitial cell	57	0.70	0.59	0.71	0.44	0.00	0.43	0.85	0.71	0.85
basal epithelial cell of tracheobronchial tree	41	0.94	0.00	0.93	0.86	0.00	0.84	0.93	0.93	0.95
plasmatocyte	50	0.82	0.84	0.81	0.82	0.00	0.45	0.90	0.79	0.91
keratinocyte stem cell	47	0.84	0.00	0.76	0.87	0.00	0.87	0.88	0.78	0.94
brush cell	42	0.90	0.91	0.75	0.87	0.00	0.75	0.87	0.74	0.91
erythroid progenitor cell, mammalian	35	0.67	0.00	0.74	0.50	0.00	0.24	0.81	0.57	0.93
naive B cell	32	0.86	0.90	0.90	0.85	0.00	0.88	0.86	0.87	0.93
kidney cortex artery cell	54	0.85	0.88	0.44	0.70	0.00	0.73	0.90	0.77	0.94
erythrocyte	34	0.81	0.47	0.65	0.63	0.00	0.70	0.80	0.81	0.81
intestinal crypt stem cell	39	0.67	0.00	0.05	0.73	0.00	0.69	0.94	0.88	0.91
epithelial cell	38	0.76	0.05	0.85	0.83	0.00	0.69	0.91	0.77	0.90
cardiac muscle cell	33	1.00	1.00	0.86	1.00	0.00	0.97	1.00	1.00	1.00
pancreatic ductal cell	32	0.98	0.55	0.86	0.95	0.00	0.91	0.97	1.00	0.97
vein endothelial cell	30	0.79	0.81	0.59	0.82	0.00	0.86	0.95	0.84	0.88
pancreatic A cell	30	0.59	0.49	0.06	0.91	0.00	0.90	0.95	0.92	0.94
myeloid leukocyte	28	0.67	0.19	0.35	0.00	0.00	0.20	0.64	0.68	0.83
Schwann cell	30	0.82	0.26	0.89	0.82	0.00	0.82	0.88	0.76	0.83
pancreatic D cell	31	0.00	0.64	0.17	0.93	0.00	0.92	0.98	0.98	0.94
mesangial cell	27	0.00	0.92	0.59	0.65	0.00	0.59	0.82	0.79	0.95
basophil	27	0.65	0.78	0.75	0.65	0.00	0.52	0.67	0.65	0.80
myeloid dendritic cell	24	0.35	0.54	0.39	0.55	0.00	0.22	0.60	0.57	0.72
epithelial cell of large intestine	26	0.00	0.00	0.31	0.79	0.00	0.76	0.82	0.81	0.85
pulmonary interstitial fibroblast	24	0.87	0.87	0.70	0.88	0.00	0.73	0.96	0.98	0.96
kidney loop of Henle ascending limb epithelial cell	28	0.00	0.26	0.00	0.07	0.00	0.59	0.44	0.68	0.23
cell of skeletal muscle	14	0.93	0.93	0.72	0.90	0.00	0.82	0.90	0.88	0.93
Langerhans cell	18	0.97	0.77	0.00	0.45	0.00	0.40	0.89	0.83	0.91
stem cell of epidermis	12	0.62	0.00	0.83	0.81	0.00	0.17	0.77	0.71	0.92
kidney capillary endothelial cell	14	0.00	0.64	0.50	0.60	0.00	0.70	0.64	0.77	0.78
large intestine goblet cell	15	0.00	0.00	0.24	0.89	0.00	0.97	0.97	0.90	0.93
pancreatic PP cell	16	0.00	0.40	0.00	0.79	0.00	0.83	0.85	0.84	0.90
macrophage dendritic cell progenitor	13	0.00	0.50	0.21	0.11	0.00	0.60	0.59	0.44	0.58
DN3 thymocyte	19	0.80	0.64	0.27	0.95	0.00	0.84	0.81	0.88	0.95
smooth muscle cell of trachea	14	0.00	0.00	0.00	0.00	0.00	0.11	0.59	0.64	0.00
pulmonary alveolar type 2 cell	8	0.94	0.89	0.80	0.86	0.00	0.86	1.00	1.00	0.94
regulatory T cell	9	0.00	0.20	0.00	0.00	0.00	0.11	0.13	0.12	0.00
plasmacytoid dendritic cell	16	0.32	0.40	0.11	0.18	0.00	0.61	0.58	0.61	0.74
smooth muscle cell of the pulmonary artery	12	0.57	0.70	0.27	0.64	0.00	0.65	0.85	0.64	0.80
kidney proximal straight tubule epithelial cell	8	0.00	0.00	0.00	0.00	0.00	0.00	0.33	0.16	0.00
blood cell	7	0.15	0.00	0.00	0.00	0.00	0.00	0.29	0.30	0.33
immature NK T cell	10	0.33	0.44	0.53	0.00	0.00	0.41	0.29	0.39	0.43
cardiac neuron	6	0.00	0.44	0.60	0.17	0.00	0.36	0.73	0.46	0.50
mast cell	7	0.00	0.00	0.43	0.00	0.00	0.32	0.80	0.75	0.75
pericyte	3	1.00	1.00	1.00	1.00	0.00	1.00	1.00	0.86	1.00
ciliated columnar cell of tracheobronchial tree	9	1.00	0.08	0.94	0.90	0.00	0.95	1.00	0.94	0.95
neuroendocrine cell	5	0.00	0.00	0.00	0.00	0.00	0.00	0.44	0.15	0.00
dendritic cell	8	0.00	0.00	0.00	0.00	0.00	0.14	0.74	0.33	0.40
endothelial cell of lymphatic vessel	3	0.00	0.00	0.80	0.40	0.00	0.08	0.40	0.25	0.80
hepatic stellate cell	2	1.00	0.67	0.67	0.80	0.00	0.33	0.80	1.00	1.00
hematopoietic stem cell	3	0.24	0.00	0.50	0.67	0.00	0.50	0.33	0.67	0.80
kidney collecting duct epithelial cell	1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
pancreatic stellate cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
club cell	1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
lung neuroendocrine cell	1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.00	0.00
kidney cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
duct epithelial cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00

The train accuracies are computed on the training data.

Cell Type	N cells	celltypist	knn bbknn	knn harmony	knn on scvi	onclass	scanvi	svm	xgboost	Consensus Prediction
B cell	27684	0.94	0.90	0.93	0.95	0.00	0.95	0.88	0.88	0.95
mesenchymal stem cell	13292	0.89	0.81	0.96	0.90	0.00	0.90	0.94	0.91	0.97
granulocyte	11395	0.87	0.89	0.92	0.92	0.00	0.91	0.82	0.87	0.92
basal cell of epidermis	10309	0.89	0.89	0.93	0.94	0.00	0.87	0.90	0.87	0.95
T cell	10261	0.84	0.78	0.78	0.85	0.00	0.90	0.75	0.79	0.90
keratinocyte	10025	0.90	0.84	0.94	0.95	0.00	0.90	0.91	0.88	0.96
endothelial cell	8928	0.91	0.91	0.88	0.92	0.00	0.91	0.96	0.92	0.97
classical monocyte	7107	0.85	0.45	0.81	0.87	0.00	0.90	0.86	0.86	0.94
granulocytopoietic cell	6796	0.79	0.73	0.91	0.87	0.00	0.87	0.79	0.84	0.90
macrophage	6411	0.70	0.63	0.79	0.76	0.00	0.81	0.72	0.74	0.85
bladder urothelial cell	4712	0.99	0.99	0.99	0.97	0.00	0.98	1.00	0.99	1.00
proerythroblast	4079	0.69	0.68	0.79	0.78	0.00	0.78	0.68	0.71	0.80
kidney proximal convoluted tubule epithelial cell	4017	0.87	0.80	0.86	0.88	0.00	0.90	0.91	0.90	0.91
endothelial cell of coronary artery	2964	0.84	0.81	0.77	0.87	0.00	0.96	0.97	0.92	0.97
epithelial cell of proximal tubule	2726	0.82	0.67	0.81	0.81	0.00	0.86	0.89	0.87	0.87
bladder cell	2711	0.97	0.96	0.99	0.89	0.00	0.94	0.99	0.97	0.99
mature NK T cell	2678	0.67	0.70	0.62	0.77	0.00	0.85	0.70	0.75	0.82
hepatocyte	2634	1.00	1.00	0.99	1.00	0.00	0.99	1.00	1.00	1.00
erythroblast	2646	0.70	0.72	0.81	0.83	0.00	0.93	0.76	0.79	0.85
promonocyte	2541	0.86	0.78	0.86	0.90	0.00	0.90	0.89	0.88	0.92
stromal cell	2516	0.72	0.01	0.97	0.72	0.00	0.89	0.94	0.83	0.94
megakaryocyte-erythroid progenitor cell	2425	0.70	0.73	0.78	0.81	0.00	0.88	0.74	0.78	0.83
type B pancreatic cell	2413	0.94	0.92	0.89	0.99	0.00	0.98	1.00	0.99	1.00
Kupffer cell	2301	0.96	0.44	0.81	0.88	0.00	0.97	0.99	0.98	0.99
natural killer cell	2215	0.86	0.85	0.71	0.86	0.00	0.87	0.89	0.90	0.91
professional antigen presenting cell	2227	0.00	0.00	0.21	0.22	0.00	0.88	0.55	0.49	0.31
fibroblast of cardiac tissue	2169	0.98	0.97	0.91	0.78	0.00	0.90	0.99	0.96	1.00
monocyte	2162	0.72	0.45	0.85	0.74	0.00	0.92	0.90	0.88	0.92
bronchial smooth muscle cell	2126	0.97	0.97	0.84	0.95	0.00	0.98	0.99	0.98	0.98
hematopoietic precursor cell	1918	0.58	0.69	0.58	0.77	0.00	0.88	0.78	0.83	0.85
pancreatic acinar cell	1920	0.99	0.00	0.88	1.00	0.00	1.00	1.00	0.99	1.00
skeletal muscle satellite cell	1856	0.98	0.98	0.99	0.99	0.00	0.98	0.99	0.97	0.99
DN4 thymocyte	1819	0.33	0.01	0.46	0.64	0.00	0.96	0.67	0.67	0.72
luminal epithelial cell of mammary gland	1712	0.93	0.91	0.97	0.94	0.00	0.96	0.96	0.96	0.98
mesenchymal stem cell of adipose tissue	1693	0.60	0.17	0.82	0.61	0.00	0.94	0.94	0.82	0.95
thymocyte	1718	0.97	0.02	0.90	0.98	0.00	0.98	0.98	0.98	0.99
myeloid cell	1689	0.60	0.03	0.66	0.64	0.00	0.97	0.85	0.82	0.89
fibroblast	1631	0.63	0.06	0.75	0.76	0.00	0.72	0.80	0.79	0.85
immature T cell	1588	0.91	0.25	0.92	0.97	0.00	0.96	0.96	0.95	0.96
intermediate monocyte	1598	0.58	0.22	0.64	0.76	0.00	0.72	0.65	0.66	0.80
epidermal cell	1537	0.92	0.00	0.93	0.92	0.00	0.95	0.93	0.93	0.96
chondrocyte	1460	0.85	0.00	0.87	0.87	0.00	0.90	0.91	0.91	0.92
plasma cell	1462	0.68	0.67	0.75	0.77	0.00	0.83	0.68	0.68	0.82
smooth muscle cell	1430	0.73	0.81	0.83	0.87	0.00	0.89	0.92	0.86	0.84
lymphocyte	1423	0.17	0.22	0.56	0.33	0.00	0.79	0.40	0.51	0.65
basal cell	1406	0.98	0.98	0.99	0.97	0.00	0.98	0.98	0.97	0.99
naive T cell	1394	0.86	0.90	0.92	0.93	0.00	0.88	0.90	0.91	0.91
kidney loop of Henle thick ascending limb epithelial cell	1404	0.93	0.93	0.94	0.93	0.00	0.93	0.97	0.96	0.95
fibroblast of lung	1365	0.96	0.93	0.94	0.96	0.00	0.98	0.99	0.99	0.99
leukocyte	1348	0.65	0.56	0.64	0.56	0.00	0.85	0.83	0.80	0.87
alveolar macrophage	1230	0.98	0.97	0.97	0.96	0.00	0.98	0.97	0.97	0.99
lung macrophage	1040	0.88	0.04	0.73	0.83	0.00	0.89	0.89	0.88	0.96
enterocyte of epithelium of large intestine	1032	0.95	0.00	0.93	0.96	0.00	0.98	0.99	0.98	0.99
fenestrated endothelial cell	922	0.87	0.88	0.72	0.82	0.00	0.87	0.97	0.95	0.96
non-classical monocyte	913	0.75	0.77	0.88	0.83	0.00	0.85	0.86	0.85	0.83
double negative thymocyte	873	0.77	0.00	0.54	0.87	0.00	0.91	0.89	0.89	0.93
precursor B cell	813	0.80	0.86	0.81	0.90	0.00	0.91	0.93	0.95	0.92
mesenchymal cell	794	0.26	0.00	0.29	0.18	0.00	0.55	0.54	0.58	0.58
CD8-positive, alpha-beta T cell	781	0.52	0.56	0.19	0.61	0.00	0.88	0.74	0.80	0.85
immature B cell	751	0.92	0.91	0.91	0.93	0.00	0.94	0.72	0.89	0.94
kidney collecting duct principal cell	706	0.89	0.95	0.96	0.96	0.00	0.97	0.98	0.98	0.98
kidney distal convoluted tubule epithelial cell	651	0.88	0.92	0.91	0.94	0.00	0.96	0.98	0.97	0.96
endocardial cell	617	0.89	0.90	0.90	0.91	0.00	0.91	0.95	0.87	0.96
endothelial cell of hepatic sinusoid	603	0.94	0.95	0.79	0.91	0.00	0.84	0.98	0.98	0.99
neutrophil	512	0.67	0.58	0.89	0.82	0.00	0.96	0.86	0.83	0.93
CD4-positive, alpha-beta T cell	512	0.29	0.28	0.35	0.59	0.00	0.86	0.62	0.64	0.86
late pro-B cell	480	0.79	0.78	0.49	0.83	0.00	0.84	0.85	0.86	0.95
adventitial cell	469	0.76	0.53	0.93	0.61	0.00	0.69	0.92	0.81	0.95
basal epithelial cell of tracheobronchial tree	480	0.96	0.00	0.97	0.91	0.00	0.97	0.97	0.98	0.99
plasmatocyte	446	0.85	0.77	0.90	0.84	0.00	0.63	0.95	0.90	0.96
keratinocyte stem cell	371	0.82	0.00	0.91	0.88	0.00	0.84	0.90	0.79	0.95
brush cell	372	0.91	0.86	0.93	0.91	0.00	0.86	0.96	0.91	0.95
erythroid progenitor cell, mammalian	374	0.68	0.00	0.91	0.78	0.00	0.31	0.81	0.62	0.94
naive B cell	366	0.89	0.91	0.92	0.92	0.00	0.93	0.95	0.96	0.96
kidney cortex artery cell	327	0.83	0.87	0.75	0.77	0.00	0.84	0.95	0.87	0.95
erythrocyte	322	0.84	0.46	0.78	0.84	0.00	0.87	0.93	0.87	0.93
intestinal crypt stem cell	300	0.66	0.00	0.81	0.85	0.00	0.94	0.98	0.98	0.99
epithelial cell	300	0.68	0.02	0.87	0.79	0.00	0.87	0.96	0.89	0.95
cardiac muscle cell	301	1.00	0.99	0.80	0.99	0.00	1.00	1.00	1.00	1.00
pancreatic ductal cell	299	0.99	0.61	0.96	0.91	0.00	0.95	0.97	0.99	0.99
vein endothelial cell	290	0.81	0.82	0.80	0.80	0.00	0.90	0.96	0.88	0.94
pancreatic A cell	280	0.52	0.02	0.54	0.92	0.00	0.95	0.98	0.97	0.98
myeloid leukocyte	277	0.78	0.05	0.82	0.29	0.00	0.70	0.77	0.90	0.98
Schwann cell	244	0.72	0.23	0.93	0.86	0.00	0.88	0.87	0.88	0.87
pancreatic D cell	241	0.00	0.45	0.81	0.95	0.00	0.94	0.98	0.98	0.98
mesangial cell	234	0.00	0.86	0.62	0.76	0.00	0.63	0.91	0.89	0.97
basophil	227	0.65	0.69	0.83	0.77	0.00	0.64	0.72	0.83	0.85
myeloid dendritic cell	221	0.38	0.67	0.81	0.61	0.00	0.85	0.71	0.74	0.92
epithelial cell of large intestine	203	0.00	0.00	0.64	0.74	0.00	0.91	0.97	0.95	0.97
pulmonary interstitial fibroblast	198	0.87	0.84	0.98	0.94	0.00	0.90	0.99	0.96	0.98
kidney loop of Henle ascending limb epithelial cell	173	0.00	0.28	0.22	0.05	0.00	0.65	0.83	0.79	0.44
cell of skeletal muscle	178	0.97	0.95	0.73	0.96	0.00	0.92	0.99	0.97	0.98
Langerhans cell	157	0.95	0.80	0.96	0.76	0.00	0.66	0.92	0.90	0.98
stem cell of epidermis	159	0.69	0.00	0.67	0.86	0.00	0.34	0.86	0.79	0.91
kidney capillary endothelial cell	147	0.00	0.57	0.40	0.66	0.00	0.83	0.91	0.88	0.91
large intestine goblet cell	143	0.00	0.00	0.91	0.93	0.00	0.99	1.00	1.00	1.00
pancreatic PP cell	141	0.00	0.00	0.64	0.86	0.00	0.90	0.98	0.99	0.99
macrophage dendritic cell progenitor	135	0.00	0.28	0.20	0.77	0.00	0.82	0.78	0.82	0.85
DN3 thymocyte	127	0.88	0.52	0.84	0.93	0.00	0.89	0.87	0.93	0.97
smooth muscle cell of trachea	113	0.00	0.00	0.37	0.29	0.00	0.84	0.77	0.91	0.67
pulmonary alveolar type 2 cell	117	0.96	0.82	0.95	0.97	0.00	0.97	1.00	1.00	0.98
regulatory T cell	114	0.00	0.03	0.03	0.19	0.00	0.53	0.48	0.42	0.69
plasmacytoid dendritic cell	100	0.41	0.37	0.35	0.65	0.00	0.91	0.84	0.90	0.93
smooth muscle cell of the pulmonary artery	86	0.58	0.66	0.81	0.73	0.00	0.77	0.91	0.88	0.91
kidney proximal straight tubule epithelial cell	87	0.00	0.00	0.00	0.00	0.00	0.53	0.61	0.46	0.48
blood cell	81	0.16	0.00	0.39	0.00	0.00	0.24	0.36	0.40	0.41
immature NK T cell	74	0.26	0.21	0.56	0.37	0.00	0.37	0.47	0.50	0.63
cardiac neuron	75	0.00	0.31	0.77	0.56	0.00	0.82	0.89	0.87	0.89
mast cell	69	0.00	0.00	0.39	0.70	0.00	0.78	0.88	0.76	0.93
pericyte	58	0.99	0.86	0.72	0.95	0.00	0.97	0.96	0.95	0.99
ciliated columnar cell of tracheobronchial tree	48	0.89	0.04	0.91	0.79	0.00	0.87	1.00	0.99	0.98
neuroendocrine cell	43	0.00	0.00	0.04	0.00	0.00	0.65	0.83	0.74	0.17
dendritic cell	37	0.00	0.15	0.28	0.10	0.00	0.21	0.69	0.60	0.97
endothelial cell of lymphatic vessel	38	0.00	0.24	0.87	0.61	0.00	0.19	0.74	0.46	0.97
hepatic stellate cell	37	0.88	0.28	0.57	0.89	0.00	0.68	0.95	0.97	1.00
hematopoietic stem cell	33	0.49	0.00	0.11	0.52	0.00	0.62	0.70	0.94	0.97
kidney collecting duct epithelial cell	24	0.00	0.00	0.00	0.00	0.00	0.87	0.98	0.92	0.15
pancreatic stellate cell	21	0.00	0.00	0.55	0.00	0.00	0.54	0.81	0.98	1.00
club cell	14	0.00	0.00	0.00	0.00	0.00	0.41	0.82	0.93	0.53
lung neuroendocrine cell	3	0.00	0.00	0.00	0.00	0.00	0.50	1.00	1.00	1.00
kidney cell	3	0.00	0.00	0.00	0.00	0.00	0.09	0.35	1.00	0.80
duct epithelial cell	2	0.00	0.00	0.00	0.00	0.00	0.12	0.33	0.67	0.00

References

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, The Tabula Muris Consortium, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, Ben A. Barres, Philip A. Beachy, Daniela Berdnik, Biter Bilen, Douglas Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, Michael F. Clarke, Stephanie D. Conley, Spyros Darmanis, Aaron Demers, Kubilay Demir, Antoine de Morree, Tessa Divita, Haley du Bois, Hamid Ebadi, F. Hernán Espinoza, Matt Fish, Qiang Gan, Benson M. George, Astrid Gillich, Rafael Gòmez-Sjöberg, Foad Green, Geraldine Genetiano, Xueying Gu, Gunsagar S. Gulati, Oliver Hahn, Michael Seamus Haney, Yan Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, Kerwyn Casey Huang, Tal Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Jim Karkanias, Guruswamy Karnam, Andreas Keller, Aaron M. Kershner, Nathalie Khoury, Seung K. Kim, Bernhard M. Kiss, William Kong, Mark A. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Lam, Davis P. Lee, Song E. Lee, Benoit Lehallier, Olivia Leventhal, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, Anoop Manjunath, Andrew P. May, Ashley Maynard, Aaron McGeever, Marina McKay, M. Windy McNerney, Bryan Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, Ahmad N. Nabhan, Norma F. Neff, Katharine M. Ng, Patricia K. Nguyen, Joseph Noh, Roel Nusse, Róbert Pálovics, Rasika Patkar, Weng Chuan Peng, Lolita Penland, Angela Oliveira Pisco, Katherine Pollard, Robert Puccinelli, Zhen Qi, Stephen R. Quake, Thomas A. Rando, Eric J. Rulifson, Nicholas Schaum, Joe M. Segal, Shaheen S. Sikandar, Rahul Sinha, Rene V. Sit, Justin Sonnenburg, Daniel Staehli, Krzysztof Szade, Michelle Tan, Weilun Tan, Cristina Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, Kyle J. Travaglini, Carolina Tropini, Margaret Tsui, Lucas Waldburger, Bruce M. Wang, Linda J. van Weele, Kenneth Weinberg, Irving L. Weissman, Michael N. Wosczyna, Sean M. Wu, Tony Wyss-Coray, Jinyi Xiang, Soso Xue, Kevin A. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chunyu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou; Nature, doi: https://doi.org/10.1038/s41586-020-2496-1