Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.

Model description

Tabula Sapiens is a benchmark, first-draft human cell atlas of over 1.1M cells from 28 organs of 24 normal human subjects. This work is the product of the Tabula Sapiens Consortium. Taking the organs from the same individual controls for genetic background, age, environment, and epigenetic effects, and allows detailed analysis and comparison of cell types that are shared between tissues.

Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.

Training Code URL: Not provided by uploader.

Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
B cell 200 0.98 0.94 0.78 0.96 0.00 0.98 0.97 0.97 0.98
CD4-positive, alpha-beta T cell 474 0.37 0.75 0.73 0.69 0.00 0.58 0.33 0.47 0.75
fibroblast 3096 0.81 0.92 0.93 0.89 0.00 0.63 0.71 0.66 0.95
CD8-positive, alpha-beta T cell 1057 0.54 0.84 0.84 0.80 0.00 0.75 0.52 0.56 0.83
neutrophil 10 0.75 0.95 0.32 0.69 0.00 1.00 0.65 0.64 0.95
macrophage 10263 0.97 0.98 0.97 0.97 0.00 0.93 0.95 0.90 0.98
stromal cell of ovary 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
endothelial cell 2909 0.75 0.94 0.95 0.86 0.00 0.73 0.67 0.63 0.93
basal cell 1602 0.77 0.89 0.90 0.90 0.00 0.77 0.78 0.71 0.89
plasma cell 35 0.76 0.94 0.42 0.93 0.00 0.94 0.96 0.94 0.93
bladder urothelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
monocyte 204 0.13 0.36 0.36 0.30 0.00 0.09 0.09 0.11 0.13
mesenchymal stem cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
smooth muscle cell 58 0.06 0.04 0.25 0.07 0.00 0.00 0.04 0.07 0.07
classical monocyte 408 0.62 0.64 0.64 0.54 0.00 0.64 0.26 0.26 0.66
luminal epithelial cell of mammary gland 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
capillary endothelial cell 458 0.58 0.84 0.81 0.69 0.00 0.49 0.68 0.61 0.77
erythrocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
natural killer cell 284 0.79 0.80 0.77 0.72 0.00 0.81 0.71 0.77 0.81
enterocyte of epithelium proper of duodenum 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
stratified squamous epithelial cell 1626 0.81 0.89 0.89 0.91 0.00 0.85 0.84 0.81 0.89
acinar cell of salivary gland 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pulmonary alveolar type 2 cell 1085 0.97 0.98 0.98 0.96 0.00 0.97 0.98 0.97 0.99
conjunctival epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pericyte 455 0.13 0.39 0.31 0.24 0.00 0.39 0.27 0.35 0.26
luminal cell of prostate epithelium 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
cardiac endothelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
naive thymus-derived CD4-positive, alpha-beta T cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
kidney epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
hepatocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
blood vessel smooth muscle cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enterocyte of epithelium proper of ileum 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
T cell 24 0.11 0.07 0.22 0.13 0.00 0.14 0.08 0.11 0.27
mast cell 131 0.37 0.37 0.76 0.44 0.00 0.60 0.77 0.67 0.57
skeletal muscle satellite stem cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
regular atrial cardiac myocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic acinar cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
intermediate monocyte 205 0.09 0.02 0.17 0.22 0.00 0.24 0.31 0.27 0.22
mature NK T cell 128 0.23 0.34 0.32 0.30 0.00 0.45 0.26 0.40 0.46
mononuclear phagocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
fibroblast of breast 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
vascular associated smooth muscle cell 1464 0.71 0.06 0.77 0.40 0.00 0.34 0.63 0.66 0.69
vein endothelial cell 48 0.07 0.10 0.42 0.17 0.00 0.13 0.07 0.14 0.33
CD4-positive, alpha-beta thymocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enterocyte of epithelium of large intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myofibroblast cell 352 0.00 0.07 0.39 0.03 0.00 0.03 0.63 0.59 0.28
thymic fibroblast type 2 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
corneal epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
spermatid 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
duct epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
mesenchymal stem cell of adipose tissue 5 0.01 0.00 0.00 0.00 0.00 0.00 0.02 0.02 0.00
basal cell of prostate epithelium 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
endothelial cell of artery 268 0.49 0.48 0.76 0.70 0.00 0.56 0.62 0.56 0.78
stromal cell 4 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
thymic fibroblast type 1 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pulmonary alveolar type 1 cell 133 0.85 0.98 0.92 0.90 0.00 0.95 0.97 0.94 0.99
spermatocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic ductal cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
regulatory T cell 3 0.00 0.00 0.00 0.50 0.00 0.12 0.12 0.13 0.40
ventricular cardiac muscle cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
endothelial cell of lymphatic vessel 52 0.48 0.77 0.95 0.79 0.00 0.51 0.65 0.44 0.86
hematopoietic precursor cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
retinal blood vessel endothelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
small intestine goblet cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
gamma-delta T cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
BEST4+ enteroycte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
fibroblast of cardiac tissue 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
paneth cell of epithelium of small intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
club cell 47 0.80 0.84 0.68 0.69 0.00 0.62 0.68 0.51 0.85
intestinal crypt stem cell of colon 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
progenitor cell of mammary luminal epithelium 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
basophil 431 0.00 0.00 0.95 0.41 0.00 0.80 0.83 0.84 0.72
large intestine goblet cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
eye photoreceptor cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
epithelial cell of uterus 120 0.96 0.76 0.84 0.29 0.00 0.44 0.95 0.87 0.96
enterocyte of epithelium proper of small intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
tissue-resident macrophage 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
acinar cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
non-classical monocyte 58 0.51 0.42 0.00 0.43 0.00 0.37 0.39 0.29 0.56
lung ciliated cell 269 0.88 0.85 0.97 0.77 0.00 0.98 0.97 0.86 0.97
activated CD8-positive, alpha-beta T cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
alveolar adventitial fibroblast 135 0.87 0.10 0.82 0.66 0.00 0.79 0.82 0.83 0.92
naive thymus-derived CD8-positive, alpha-beta T cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
adventitial cell 33 0.00 0.00 0.67 0.00 0.00 0.11 0.33 0.16 0.38
respiratory goblet cell 200 0.93 0.92 0.96 0.91 0.00 0.92 0.94 0.69 0.96
theca cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myeloid leukocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
keratocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enteroglial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
innate lymphoid cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
erythroid progenitor cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myometrial cell 652 0.92 0.00 0.86 0.59 0.00 0.56 0.76 0.74 0.90
endothelial cell of vascular tree 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
hematopoietic stem cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
salivary gland cell 2 0.00 0.00 0.00 0.00 0.00 0.00 0.12 0.00 0.00
granulocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
CD8-positive, alpha-beta thymocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ciliated columnar cell of tracheobronchial tree 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
intrahepatic cholangiocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
mural cell 28 0.69 0.78 0.89 0.00 0.00 0.42 0.48 0.58 0.86
intestinal crypt stem cell of small intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
activated CD4-positive, alpha-beta T cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myeloid dendritic cell 17 0.04 0.00 0.10 0.10 0.00 0.08 0.07 0.07 0.04
Mueller cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
fast muscle cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
platelet 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myoepithelial cell 2 0.00 0.00 0.67 0.15 0.00 0.00 0.00 0.00 0.00
common myeloid progenitor 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
thymocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
intestinal tuft cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic stellate cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
tendon cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
microglial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
muscle cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enterocyte of epithelium proper of jejunum 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
mesothelial cell 6 1.00 0.91 0.80 0.91 0.00 0.55 0.60 0.73 1.00
colon endothelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
colon macrophage 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
serous cell of epithelium of trachea 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ciliated epithelial cell 2 0.00 0.00 0.00 0.20 0.00 0.67 1.00 0.40 1.00
Schwann cell 4 0.00 0.00 0.25 0.33 0.00 0.00 0.24 0.22 0.22
supporting cell of vestibular epithelium 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
mucus secreting cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enteroendocrine cell of small intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ovarian surface epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
transit amplifying cell of colon 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
glandular epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
melanocyte 6 0.00 0.50 0.73 0.29 0.00 0.86 0.43 0.57 0.91
tracheal goblet cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
hepatic stellate cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
bronchial smooth muscle cell 23 0.00 0.00 0.43 0.00 0.00 0.48 0.44 0.45 0.46
paneth cell of colon 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
tongue muscle cell 23 0.00 0.00 0.90 0.16 0.00 0.63 0.46 0.44 0.69
leukocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
tuft cell of colon 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
slow muscle cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ionocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
connective tissue cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
neuro-medullary thymic epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
sebum secreting cell 2 0.00 0.17 1.00 1.00 0.00 0.67 0.50 0.50 0.80
endothelial cell of arteriole 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
male germ cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
type B pancreatic cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
hematopoietic cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
plasmacytoid dendritic cell 17 0.00 0.30 0.00 0.30 0.00 0.86 0.83 1.00 0.94
neuron 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myeloid cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
myo-medullary thymic epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Langerhans cell 3 0.00 0.00 0.80 0.00 0.00 0.44 0.00 0.00 0.00
interstitial cell of Cajal 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
peritubular myoid cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
retinal pigment epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
spermatogonium 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
retinal bipolar neuron 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
endothelial cell of venule 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
vestibular dark cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic A cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
type L enteroendocrine cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
medullary thymic epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
adipocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
transit amplifying cell of small intestine 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
taste receptor cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enterochromaffin-like cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
enteroendocrine cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pulmonary ionocyte 3 0.00 0.00 0.00 0.00 0.00 1.00 0.33 0.50 0.00
glial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
oocyte 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
serous cell of epithelium of bronchus 4 0.00 0.40 0.00 0.00 0.00 0.89 0.50 0.67 0.67
radial glial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Leydig cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
unassigned 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic D cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
T follicular helper cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
retina horizontal cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
mesenchymal cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
erythroid lineage cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
epithelial fate stem cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic PP cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
retinal ganglion cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00

The train accuracies are computed on the training data.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
B cell 114295 0.99 0.99 0.99 0.99 0.00 0.99 0.98 0.98 0.99
CD4-positive, alpha-beta T cell 96656 0.60 0.78 0.86 0.80 0.00 0.59 0.43 0.51 0.81
fibroblast 80242 0.82 0.75 0.95 0.81 0.00 0.78 0.67 0.68 0.91
CD8-positive, alpha-beta T cell 75220 0.68 0.77 0.84 0.78 0.00 0.73 0.52 0.62 0.81
neutrophil 69529 0.96 0.98 0.98 0.99 0.00 0.95 0.95 0.93 0.98
macrophage 58809 0.75 0.81 0.93 0.85 0.00 0.77 0.68 0.68 0.89
stromal cell of ovary 35003 0.96 0.60 0.93 0.91 0.00 0.94 0.96 0.94 0.98
endothelial cell 30794 0.69 0.68 0.94 0.75 0.00 0.79 0.68 0.63 0.88
basal cell 31924 0.87 0.83 0.92 0.86 0.00 0.85 0.86 0.81 0.94
plasma cell 27314 0.97 0.97 0.97 0.98 0.00 0.98 0.97 0.97 0.99
bladder urothelial cell 27241 0.98 0.96 0.97 0.86 0.00 0.94 0.98 0.97 0.99
monocyte 25549 0.40 0.33 0.83 0.65 0.00 0.55 0.50 0.56 0.68
mesenchymal stem cell 23497 0.86 0.72 0.93 0.69 0.00 0.91 0.89 0.82 0.95
smooth muscle cell 18367 0.74 0.65 0.91 0.80 0.00 0.81 0.76 0.77 0.86
classical monocyte 17792 0.61 0.53 0.81 0.68 0.00 0.67 0.60 0.65 0.75
luminal epithelial cell of mammary gland 15432 0.98 0.00 0.97 0.86 0.00 0.95 0.98 0.96 0.99
capillary endothelial cell 14838 0.71 0.57 0.91 0.73 0.00 0.80 0.70 0.70 0.84
erythrocyte 14611 0.96 0.96 0.97 0.98 0.00 0.96 0.95 0.96 0.97
natural killer cell 13947 0.69 0.73 0.80 0.74 0.00 0.74 0.69 0.71 0.76
enterocyte of epithelium proper of duodenum 13495 0.87 0.29 0.86 0.83 0.00 0.94 0.90 0.89 0.96
stratified squamous epithelial cell 10697 0.80 0.77 0.90 0.87 0.00 0.85 0.84 0.79 0.89
acinar cell of salivary gland 12237 0.95 0.74 0.96 0.85 0.00 0.96 0.94 0.91 0.97
pulmonary alveolar type 2 cell 10509 0.92 0.95 0.98 0.94 0.00 0.95 0.96 0.95 0.97
conjunctival epithelial cell 11087 0.93 0.69 0.88 0.73 0.00 0.93 0.94 0.91 0.96
pericyte 10429 0.62 0.50 0.88 0.69 0.00 0.67 0.69 0.68 0.79
luminal cell of prostate epithelium 10652 0.86 0.54 0.95 0.84 0.00 0.93 0.94 0.92 0.96
cardiac endothelial cell 10092 0.93 0.80 0.97 0.78 0.00 0.92 0.94 0.89 0.97
naive thymus-derived CD4-positive, alpha-beta T cell 9827 0.23 0.02 0.42 0.04 0.00 0.28 0.24 0.29 0.32
kidney epithelial cell 9278 0.98 0.14 0.97 0.92 0.00 0.99 0.99 0.98 0.99
hepatocyte 7414 0.94 0.98 0.98 0.94 0.00 0.99 0.98 0.96 1.00
blood vessel smooth muscle cell 6642 0.76 0.21 0.94 0.75 0.00 0.93 0.89 0.79 0.93
enterocyte of epithelium proper of ileum 6477 0.96 0.00 0.83 0.71 0.00 0.96 0.98 0.96 0.98
T cell 6266 0.38 0.19 0.67 0.27 0.00 0.50 0.35 0.40 0.60
mast cell 6091 0.87 0.87 0.96 0.91 0.00 0.95 0.92 0.91 0.95
skeletal muscle satellite stem cell 6168 0.94 0.93 0.97 0.91 0.00 0.96 0.93 0.92 0.97
regular atrial cardiac myocyte 5816 0.82 0.63 0.88 0.84 0.00 0.96 0.92 0.91 0.94
pancreatic acinar cell 5482 0.95 0.01 0.96 0.86 0.00 0.97 0.96 0.96 0.98
intermediate monocyte 5273 0.28 0.11 0.65 0.31 0.00 0.40 0.39 0.45 0.53
mature NK T cell 5266 0.40 0.36 0.61 0.46 0.00 0.54 0.41 0.47 0.60
mononuclear phagocyte 5336 0.39 0.00 0.94 0.39 0.00 0.78 0.59 0.54 0.88
fibroblast of breast 5270 0.91 0.00 0.97 0.65 0.00 0.94 0.84 0.70 0.97
vascular associated smooth muscle cell 3555 0.64 0.01 0.82 0.54 0.00 0.69 0.59 0.60 0.75
vein endothelial cell 4650 0.37 0.10 0.82 0.42 0.00 0.66 0.53 0.49 0.70
CD4-positive, alpha-beta thymocyte 4685 0.37 0.00 0.70 0.37 0.00 0.61 0.39 0.38 0.66
enterocyte of epithelium of large intestine 4567 0.78 0.28 0.77 0.72 0.00 0.86 0.86 0.86 0.93
myofibroblast cell 4084 0.66 0.18 0.88 0.60 0.00 0.51 0.60 0.62 0.83
thymic fibroblast type 2 4205 0.60 0.00 0.80 0.50 0.00 0.86 0.67 0.58 0.85
corneal epithelial cell 4187 0.93 0.00 0.94 0.91 0.00 0.95 0.95 0.93 0.96
spermatid 4009 0.91 0.00 0.98 0.97 0.00 0.97 0.99 0.97 0.99
duct epithelial cell 3889 0.75 0.23 0.89 0.69 0.00 0.86 0.82 0.78 0.91
mesenchymal stem cell of adipose tissue 3772 0.30 0.00 0.65 0.49 0.00 0.52 0.35 0.35 0.53
basal cell of prostate epithelium 3495 0.68 0.02 0.91 0.66 0.00 0.84 0.85 0.80 0.88
endothelial cell of artery 3203 0.39 0.32 0.77 0.49 0.00 0.61 0.61 0.55 0.73
stromal cell 3454 0.60 0.00 0.65 0.59 0.00 0.75 0.75 0.74 0.86
thymic fibroblast type 1 3270 0.17 0.00 0.85 0.17 0.00 0.76 0.61 0.46 0.80
pulmonary alveolar type 1 cell 2983 0.91 0.87 0.97 0.83 0.00 0.90 0.97 0.93 0.98
spermatocyte 3070 0.82 0.00 0.97 0.92 0.00 0.95 0.98 0.96 0.98
pancreatic ductal cell 2721 0.89 0.04 0.94 0.80 0.00 0.92 0.96 0.92 0.97
regulatory T cell 2646 0.12 0.01 0.28 0.03 0.00 0.29 0.31 0.34 0.41
ventricular cardiac muscle cell 2599 0.31 0.00 0.73 0.68 0.00 0.96 0.84 0.83 0.83
endothelial cell of lymphatic vessel 2386 0.64 0.50 0.91 0.58 0.00 0.58 0.65 0.61 0.76
hematopoietic precursor cell 2140 0.49 0.65 0.79 0.76 0.00 0.57 0.62 0.62 0.73
retinal blood vessel endothelial cell 2091 0.23 0.00 0.89 0.25 0.00 0.95 0.67 0.59 0.90
small intestine goblet cell 2044 0.84 0.51 0.92 0.78 0.00 0.86 0.94 0.91 0.95
gamma-delta T cell 1977 0.34 0.06 0.70 0.26 0.00 0.52 0.51 0.47 0.74
BEST4+ enteroycte 1970 0.00 0.43 0.81 0.67 0.00 0.85 0.86 0.85 0.90
fibroblast of cardiac tissue 1947 0.94 0.28 0.97 0.53 0.00 0.43 0.78 0.77 0.96
paneth cell of epithelium of small intestine 1853 0.50 0.40 0.77 0.58 0.00 0.68 0.71 0.72 0.84
club cell 1700 0.76 0.67 0.87 0.67 0.00 0.76 0.80 0.77 0.88
intestinal crypt stem cell of colon 1732 0.73 0.41 0.78 0.72 0.00 0.79 0.85 0.85 0.89
progenitor cell of mammary luminal epithelium 1694 0.98 0.00 0.98 0.96 0.00 0.93 0.92 0.93 0.99
epithelial cell 1675 0.88 0.28 0.97 0.76 0.00 0.81 0.91 0.91 0.95
basophil 1238 0.00 0.01 0.94 0.60 0.00 0.84 0.69 0.75 0.89
large intestine goblet cell 1557 0.85 0.52 0.90 0.70 0.00 0.81 0.93 0.88 0.94
eye photoreceptor cell 1536 0.89 0.89 0.96 0.94 0.00 0.95 0.97 0.98 0.98
epithelial cell of uterus 1297 0.84 0.17 0.96 0.54 0.00 0.92 0.86 0.79 0.98
enterocyte of epithelium proper of small intestine 1415 0.26 0.00 0.76 0.35 0.00 0.77 0.66 0.68 0.78
tissue-resident macrophage 1355 0.49 0.00 0.81 0.51 0.00 0.56 0.37 0.53 0.71
acinar cell 1345 0.82 0.15 0.97 0.91 0.00 0.91 0.85 0.84 0.93
non-classical monocyte 1226 0.25 0.30 0.43 0.36 0.00 0.24 0.33 0.39 0.55
lung ciliated cell 940 0.67 0.16 0.96 0.81 0.00 0.97 0.94 0.92 0.97
activated CD8-positive, alpha-beta T cell 1147 0.36 0.00 0.83 0.11 0.00 0.56 0.31 0.31 0.68
alveolar adventitial fibroblast 978 0.69 0.02 0.87 0.44 0.00 0.62 0.66 0.72 0.91
naive thymus-derived CD8-positive, alpha-beta T cell 1056 0.13 0.00 0.50 0.00 0.00 0.21 0.15 0.15 0.44
adventitial cell 1012 0.21 0.00 0.76 0.11 0.00 0.28 0.34 0.37 0.72
respiratory goblet cell 840 0.37 0.34 0.84 0.49 0.00 0.54 0.59 0.58 0.81
theca cell 1038 0.68 0.00 0.85 0.74 0.00 0.44 0.74 0.66 0.84
myeloid leukocyte 1002 0.28 0.00 0.76 0.18 0.00 0.57 0.32 0.25 0.74
keratocyte 1001 0.34 0.01 0.59 0.05 0.00 0.53 0.45 0.46 0.65
enteroglial cell 990 0.76 0.58 0.95 0.85 0.00 0.75 0.90 0.78 0.87
innate lymphoid cell 971 0.17 0.09 0.48 0.20 0.00 0.52 0.24 0.27 0.45
erythroid progenitor cell 971 0.59 0.56 0.82 0.72 0.00 0.62 0.77 0.73 0.76
myometrial cell 265 0.28 0.00 0.53 0.34 0.00 0.42 0.44 0.44 0.76
endothelial cell of vascular tree 875 0.15 0.03 0.74 0.47 0.00 0.63 0.52 0.49 0.80
hematopoietic stem cell 858 0.72 0.57 0.79 0.77 0.00 0.74 0.85 0.84 0.84
salivary gland cell 848 0.47 0.00 0.90 0.61 0.00 0.76 0.71 0.61 0.89
granulocyte 769 0.28 0.00 0.61 0.46 0.00 0.41 0.28 0.21 0.73
CD8-positive, alpha-beta thymocyte 731 0.00 0.00 0.44 0.17 0.00 0.44 0.28 0.33 0.61
ciliated columnar cell of tracheobronchial tree 713 0.40 0.03 0.95 0.77 0.00 0.95 0.90 0.86 0.97
intrahepatic cholangiocyte 665 0.97 0.17 0.97 0.61 0.00 0.96 0.96 0.89 0.98
mural cell 590 0.25 0.18 0.94 0.25 0.00 0.76 0.49 0.53 0.95
intestinal crypt stem cell of small intestine 587 0.00 0.08 0.31 0.11 0.00 0.37 0.54 0.59 0.68
activated CD4-positive, alpha-beta T cell 572 0.03 0.00 0.42 0.01 0.00 0.23 0.13 0.13 0.31
myeloid dendritic cell 554 0.15 0.05 0.48 0.26 0.00 0.16 0.21 0.22 0.31
Mueller cell 506 0.58 0.38 0.81 0.77 0.00 0.84 0.91 0.93 0.91
fast muscle cell 495 0.30 0.55 0.92 0.80 0.00 0.92 0.75 0.85 0.91
platelet 494 0.91 0.89 0.93 0.94 0.00 0.68 0.86 0.80 0.93
myoepithelial cell 484 0.44 0.21 0.88 0.74 0.00 0.45 0.52 0.42 0.83
common myeloid progenitor 456 0.00 0.36 0.78 0.62 0.00 0.65 0.80 0.82 0.85
thymocyte 455 0.00 0.00 0.59 0.27 0.00 0.50 0.24 0.32 0.85
intestinal tuft cell 448 0.81 0.75 0.96 0.79 0.00 0.93 0.92 0.98 0.95
pancreatic stellate cell 438 0.00 0.00 0.90 0.36 0.00 0.38 0.57 0.60 0.78
tendon cell 420 0.00 0.05 0.69 0.34 0.00 0.32 0.41 0.31 0.79
microglial cell 410 0.13 0.00 0.71 0.01 0.00 0.33 0.28 0.23 0.64
muscle cell 406 0.51 0.00 0.97 0.93 0.00 0.89 0.62 0.94 0.95
enterocyte of epithelium proper of jejunum 405 0.00 0.00 0.43 0.12 0.00 0.92 0.58 0.44 0.74
mesothelial cell 344 0.48 0.41 0.91 0.72 0.00 0.56 0.69 0.72 0.77
colon endothelial cell 348 0.00 0.01 0.81 0.10 0.00 0.61 0.36 0.30 0.86
colon macrophage 328 0.00 0.00 0.81 0.09 0.00 0.47 0.34 0.28 0.89
serous cell of epithelium of trachea 326 0.39 0.00 0.83 0.45 0.00 0.49 0.55 0.55 0.84
ciliated epithelial cell 318 0.00 0.00 0.96 0.72 0.00 0.83 0.82 0.94 0.99
Schwann cell 314 0.58 0.30 0.83 0.54 0.00 0.71 0.62 0.71 0.79
supporting cell of vestibular epithelium 270 0.00 0.00 0.62 0.74 0.00 0.94 0.99 0.85 0.99
mucus secreting cell 270 0.00 0.02 0.83 0.55 0.00 0.70 0.73 0.77 0.86
enteroendocrine cell of small intestine 264 0.52 0.13 0.80 0.68 0.00 0.88 0.88 0.85 0.90
ovarian surface epithelial cell 241 0.00 0.17 0.89 0.68 0.00 0.56 0.64 0.67 0.88
transit amplifying cell of colon 237 0.00 0.25 0.60 0.40 0.00 0.47 0.73 0.64 0.82
glandular epithelial cell 235 0.00 0.03 0.82 0.47 0.00 0.89 0.83 0.69 0.98
melanocyte 228 0.00 0.26 0.83 0.51 0.00 0.78 0.61 0.74 0.92
tracheal goblet cell 232 0.00 0.13 0.76 0.58 0.00 0.15 0.77 0.64 0.91
hepatic stellate cell 223 0.00 0.00 0.66 0.04 0.00 0.43 0.41 0.45 0.80
bronchial smooth muscle cell 197 0.00 0.00 0.64 0.06 0.00 0.47 0.39 0.48 0.81
paneth cell of colon 217 0.00 0.00 0.74 0.33 0.00 0.70 0.82 0.81 0.91
tongue muscle cell 179 0.00 0.00 0.85 0.14 0.00 0.61 0.54 0.51 0.91
leukocyte 201 0.00 0.02 0.47 0.02 0.00 0.42 0.18 0.18 0.65
tuft cell of colon 178 0.00 0.07 0.81 0.34 0.00 0.82 0.89 0.83 0.94
slow muscle cell 174 0.00 0.28 0.87 0.57 0.00 0.81 0.80 0.91 0.93
ionocyte 160 0.00 0.06 0.76 0.63 0.00 0.66 0.58 0.74 0.91
connective tissue cell 152 0.00 0.00 0.92 0.35 0.00 0.50 0.23 0.35 0.92
neuro-medullary thymic epithelial cell 135 0.28 0.30 0.76 0.61 0.00 0.36 0.38 0.54 0.45
sebum secreting cell 133 0.00 0.01 0.90 0.56 0.00 0.48 0.64 0.75 0.90
endothelial cell of arteriole 132 0.00 0.00 0.91 0.00 0.00 0.64 0.45 0.44 0.97
male germ cell 116 0.00 0.00 0.86 0.70 0.00 0.92 1.00 0.85 1.00
type B pancreatic cell 102 0.00 0.00 0.91 0.78 0.00 0.94 0.94 0.91 1.00
hematopoietic cell 100 0.00 0.00 0.67 0.41 0.00 0.23 0.48 0.45 0.76
plasmacytoid dendritic cell 82 0.00 0.44 0.46 0.51 0.00 0.11 0.37 0.44 0.68
neuron 82 0.00 0.00 0.96 0.74 0.00 0.31 0.61 0.69 0.94
myeloid cell 81 0.00 0.00 0.44 0.00 0.00 0.50 0.24 0.28 0.83
myo-medullary thymic epithelial cell 77 0.00 0.00 0.90 0.70 0.00 0.78 0.66 0.91 0.96
Langerhans cell 73 0.00 0.00 0.72 0.39 0.00 0.18 0.27 0.35 0.74
interstitial cell of Cajal 71 0.00 0.00 0.95 0.13 0.00 0.33 0.37 0.55 0.95
peritubular myoid cell 67 0.21 0.00 0.56 0.36 0.00 0.48 0.72 0.56 0.74
retinal pigment epithelial cell 67 0.00 0.03 0.91 0.72 0.00 0.61 1.00 0.89 0.95
spermatogonium 64 0.00 0.00 0.54 0.29 0.00 0.40 0.90 0.78 0.74
retinal bipolar neuron 61 0.00 0.03 0.72 0.69 0.00 0.61 0.75 0.92 0.91
endothelial cell of venule 52 0.00 0.00 0.91 0.00 0.00 0.41 0.67 0.48 0.97
vestibular dark cell 49 0.00 0.00 0.31 0.18 0.00 0.75 0.99 0.84 1.00
pancreatic A cell 48 0.00 0.00 0.92 0.78 0.00 0.88 1.00 0.99 0.99
type L enteroendocrine cell 44 0.00 0.00 0.77 0.19 0.00 0.94 0.96 0.97 0.96
medullary thymic epithelial cell 43 0.00 0.00 0.46 0.00 0.00 0.23 0.26 0.70 0.83
adipocyte 39 0.00 0.00 0.72 0.44 0.00 0.32 0.66 0.51 0.86
transit amplifying cell of small intestine 34 0.00 0.00 0.32 0.19 0.00 0.17 0.60 0.62 0.91
taste receptor cell 32 0.00 0.00 0.73 0.00 0.00 0.33 0.57 0.29 0.88
enterochromaffin-like cell 27 0.00 0.05 0.60 0.56 0.00 0.83 0.76 0.90 0.90
enteroendocrine cell 25 0.00 0.00 0.86 0.38 0.00 0.62 0.89 0.93 0.94
pulmonary ionocyte 22 0.00 0.00 0.76 0.08 0.00 0.33 0.70 0.85 0.93
glial cell 20 0.00 0.00 0.70 0.00 0.00 0.13 0.49 0.34 0.58
oocyte 18 0.00 0.01 0.97 0.78 0.00 0.55 0.60 0.97 0.90
serous cell of epithelium of bronchus 11 0.00 0.00 0.17 0.00 0.00 0.13 0.08 0.92 1.00
radial glial cell 13 0.00 0.00 0.00 0.00 0.00 0.04 0.28 0.25 0.52
Leydig cell 10 0.00 0.00 0.00 0.00 0.00 0.02 0.33 0.69 0.95
unassigned 9 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic D cell 9 0.00 0.00 0.20 0.00 0.00 0.72 0.95 0.86 1.00
T follicular helper cell 6 0.00 0.00 0.00 0.00 0.00 0.05 0.06 0.33 0.67
retina horizontal cell 5 0.00 0.00 0.00 0.00 0.00 0.43 1.00 0.91 0.67
mesenchymal cell 2 0.00 0.00 0.00 0.00 0.00 0.04 0.03 0.18 0.00
erythroid lineage cell 2 0.00 0.00 0.00 0.00 0.00 0.67 0.02 1.00 0.00
epithelial fate stem cell 2 0.00 0.00 0.00 0.00 0.00 0.03 0.80 0.67 0.67
pancreatic PP cell 2 0.00 0.00 0.00 0.00 0.00 0.04 1.00 1.00 0.67
retinal ganglion cell 1 0.00 0.00 0.00 0.00 0.00 0.00 0.02 1.00 1.00

References

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues, The Tabula Sapiens Consortium; bioRxiv, doi: https://doi.org/10.1101/2024.12.03.626516

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