| --- |
| license: mit |
| library_name: pyaging |
| tags: |
| - pyaging |
| - aging-clock |
| - biology |
| - dna-methylation |
| --- |
| |
| # corticalclock |
|
|
| Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years. |
|
|
| | | | |
| |---|---| |
| | **Predicts** | chronological age | |
| | **Species** | Homo sapiens | |
| | **Tissue** | brain cortex | |
| | **Data type** | DNA methylation | |
| | **Model type** | elastic net regression | |
| | **Year** | 2020 | |
|
|
| ## Use with pyaging |
|
|
| ```python |
| import pyaging as pya |
| |
| pya.pred.predict_age(adata, ["corticalclock"]) |
| ``` |
|
|
| Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io). |
|
|
| ## Citation |
|
|
| Shireby, G. L., et al. "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex." Brain 143.12 (2020): 3763-3775. |
|
|
| https://doi.org/10.1093/brain/awaa334 |
|
|
