dnamic

Whole-blood DNA-methylation predictor of intrinsic capacity, an average score across cognition, locomotion, psychological, sensory, and vitality domains; trained with tenfold cross-validated elastic net on INSPIRE-T and returning higher values for better capacity.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts	intrinsic capacity
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	elastic net regression
Year	2025

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["dnamic"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Fuentealba, M., Rouch, L., Guyonnet, S. et al. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nature Aging 5, 1207–1216 (2025).

https://doi.org/10.1038/s43587-025-00883-5