grimage

Age-calibrated mortality-risk estimator built in two stages from DNAm surrogates for plasma proteins and smoking pack-years, chronological age, and sex.

Model weights retain the original authors' terms; the pyaging software license does not relicense them. These weights are restricted to research use under the authors' terms.

Predicts mortality risk
Species Homo sapiens
Tissue whole blood
Data type DNA methylation
Model type two-stage elastic net + Cox regression
Year 2019

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["grimage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Lu, Ake T., et al. "DNA methylation GrimAge strongly predicts lifespan and healthspan." Aging (Albany NY) 11 (2019): 303–327.

https://doi.org/10.18632/aging.101684

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