mccartneysmoking

Whole-blood DNAm LASSO score trained on log(smoking pack-years + 1), residualized for age, sex and ten genetic principal components. The returned linear score remains on that adjusted natural-log scale; it is not an absolute exposure in physical units. Evaluated out of sample in LBC1936.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts	smoking exposure
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	LASSO regression
Year	2018

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["mccartneysmoking"])

Browse every clock in the pyaging Clock Catalogue.

Citation

McCartney, D. L., et al. “Epigenetic prediction of complex traits and death.” Genome Biology 19, 136 (2018).

https://doi.org/10.1186/s13059-018-1514-1