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File size: 3,418 Bytes
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# ============================================================
# Stage 1: Composer dependencies
# ============================================================
FROM composer:2.8 AS vendor
WORKDIR /app
RUN apk add --no-cache icu-dev libzip-dev oniguruma-dev \
&& docker-php-ext-install intl zip mbstring bcmath pcntl
# Add build argument for composer dev dependencies
COPY composer.json composer.lock ./
RUN composer install \
--no-interaction \
--no-scripts \
--prefer-dist \
--optimize-autoloader
COPY . .
RUN composer dump-autoload --optimize --classmap-authoritative
# ============================================================
# Stage 2: Frontend assets (Vite)
# ============================================================
FROM node:22-alpine AS assets
WORKDIR /app
COPY package.json package-lock.json ./
RUN npm ci
COPY vite.config.js ./
COPY resources ./resources
COPY public ./public
RUN npm run build
# ============================================================
# Stage 3: Runtime (PHP CLI on Debian — artisan serve)
# ============================================================
FROM php:8.3-cli AS runtime
RUN apt-get update && apt-get install -y \
libicu-dev \
libzip-dev \
libonig-dev \
libsqlite3-dev \
wget \
bzip2 \
ca-certificates \
openbabel \
supervisor \
&& docker-php-ext-install \
pdo_sqlite \
zip \
intl \
mbstring \
bcmath \
opcache \
pcntl \
&& rm -rf /var/lib/apt/lists/*
COPY docker/php/opcache.ini /usr/local/etc/php/conf.d/opcache.ini
# Install Miniconda
ENV CONDA_DIR=/opt/conda
RUN wget --quiet https://repo.anaconda.com/miniconda/Miniconda3-latest-Linux-x86_64.sh -O /tmp/miniconda.sh && \
/bin/bash /tmp/miniconda.sh -b -p $CONDA_DIR && \
rm /tmp/miniconda.sh
ENV PATH=$CONDA_DIR/bin:$PATH
# Accept Anaconda ToS (required in CI/Docker)
RUN conda tos accept --override-channels --channel https://repo.anaconda.com/pkgs/main && \
conda tos accept --override-channels --channel https://repo.anaconda.com/pkgs/r
# Create environment
RUN conda create -y -p /var/www/html/vina_env -c conda-forge \
vina=1.2.5 \
python=3.10 \
pip
# Install RDKit via pip to bypass Boost C++ solver compatibility conflicts
RUN /var/www/html/vina_env/bin/pip install rdkit==2025.09.5
# Install testing and service dependencies from requirements.txt
COPY requirements.txt /tmp/requirements.txt
RUN /var/www/html/vina_env/bin/pip install -r /tmp/requirements.txt
ENV PATH=/var/www/html/vina_env/bin:$PATH
WORKDIR /var/www/html
COPY --from=vendor --chown=www-data:www-data /app /var/www/html
COPY --from=assets --chown=www-data:www-data /app/public/build /var/www/html/public/build
COPY docker/entrypoint.sh /usr/local/bin/entrypoint.sh
COPY docker/supervisord.conf /etc/supervisor/conf.d/supervisord.conf
RUN chmod +x /usr/local/bin/entrypoint.sh \
&& mkdir -p storage/framework/{cache,sessions,views} storage/logs bootstrap/cache database \
&& chown -R www-data:www-data storage bootstrap/cache database /var/www/html/vina_env
USER www-data
EXPOSE 8000 7860
HEALTHCHECK --interval=15s --timeout=5s --start-period=40s --retries=5 \
CMD php -r "exit((int)(@file_get_contents('http://127.0.0.1:8000') === false));"
ENTRYPOINT ["/usr/local/bin/entrypoint.sh"]
CMD ["php", "artisan", "serve", "--host=0.0.0.0", "--port=8000"]
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