Update data/rag/knowledge_base/Comamonas/testosteroni.json

data/rag/knowledge_base/Comamonas/testosteroni.json

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+{
+  "genus": "Comamonas",
+  "species": "testosteronii",
+  "full_name": "Comamonas testosteronii",
+  "clinical_significance": "Primarily an environmental organism involved in degradation of steroids such as testosterone. Rarely isolated from human clinical specimens. Most isolations represent colonization or contamination, though occasional opportunistic infections are reported in immunocompromised patients.",
+  "phenotype_profile": {
+    "morphology": "Motile Gram-negative rods with polar flagella.",
+    "culture": "Smooth, non-pigmented colonies on routine media. NLF on MacConkey.",
+    "biochemical": [
+      "Oxidase positive",
+      "Catalase positive",
+      "Non-fermentative",
+      "Indole negative",
+      "Nitrate reduction positive",
+      "ONPG negative",
+      "Urease negative",
+      "Motile"
+    ]
+  },
+  "differentiation": {
+    "from close species": [
+      "Less frequently pathogenic than C. kerstersii.",
+      "Distinguished by specific carbon assimilation patterns (e.g., steroid degradation).",
+      "MALDI-TOF MS required for reliable speciation."
+    ],
+    "from other genera": [
+      "Oxidase positivity and motility with non-fermentative metabolism resembles Delftia but lacks DNase activity.",
+      "No pigment differentiates from Pseudomonas aeruginosa."
+    ]
+  },
+  "virulence_factors": [
+    "Environmental persistence",
+    "Biofilm formation in water systems (rare clinical relevance)"
+  ],
+  "confirmation_methods": [
+    "MALDI-TOF MS",
+    "16S rRNA sequencing",
+    "Substrate assimilation testing (research)"
+  ],
+  "treatment_notes": "Typically susceptible to fluoroquinolones, carbapenems, and TMP-SMX. Treatment only required for confirmed infections.",
+  "notes": "Most reported clinical isolates are incidental; pathogenicity generally low.",
+  "references": [
+    "Environmental Comamonas literature",
+    "Rare Comamonas infection case reports"
+  ]
+}