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Update data/rag/knowledge_base/Acinetobacter/junii.json

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data/rag/knowledge_base/Acinetobacter/junii.json CHANGED
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+ {
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+ "genus": "Acinetobacter",
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+ "species": "junii",
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+ "full_name": "Acinetobacter junii",
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+ "clinical_significance": "A less pathogenic species compared to A. baumannii. Often isolated in neonates and immunocompromised patients, causing bacteremia, meningitis, and wound infections. Generally more susceptible to antibiotics.",
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+ "phenotype_profile": {
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+ "morphology": "Gram-negative coccobacilli; may appear slightly longer than baumannii.",
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+ "culture": "Smooth, moist colonies on blood agar. Non-lactose fermenting on MacConkey agar.",
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+ "biochemical": [
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+ "Oxidase negative",
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+ "Catalase positive",
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+ "Non-fermenter",
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+ "ONPG negative",
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+ "Does not grow in 6.5% NaCl",
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+ "Non-motile",
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+ "Does NOT grow at 44°C",
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+ "Weak or absent glucose oxidation"
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+ ]
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+ },
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+ "differentiation": {
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+ "from_close_species": [
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+ "Does not grow at 44°C, unlike A. baumannii.",
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+ "More antibiotic susceptible than A. baumannii.",
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+ "Colony morphology more moist and less adherent.",
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+ "Genetic identification required for reliable distinction."
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+ ],
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+ "from_other_genera": [
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+ "Oxidase negative non-motile phenotype differentiates from Stenotrophomonas and Alcaligenes.",
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+ "Coccobacillary morphology may mimic Neisseria, but oxidase negative result rules them out."
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+ ]
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+ },
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+ "confirmation_methods": [
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+ "MALDI-TOF MS",
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+ "16S rRNA sequencing",
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+ "Inability to grow at 44°C (supports species assignment)",
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+ "Genome-based identification for high accuracy"
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+ ],
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+ "treatment_notes": "Typically susceptible to more antibiotics than baumannii. Standard beta-lactams, fluoroquinolones, and aminoglycosides may be effective.",
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+ "notes": "Commonly isolated from neonatal intensive care units; pathogenicity lower than baumannii but still clinically relevant.",
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+ "references": [
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+ "Manual of Clinical Microbiology.",
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+ "NICU infection surveillance literature."
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+ ]
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+ }