Update data/rag/knowledge_base/Acinetobacter/junii.json
Browse files
data/rag/knowledge_base/Acinetobacter/junii.json
CHANGED
|
@@ -0,0 +1,44 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
{
|
| 2 |
+
"genus": "Acinetobacter",
|
| 3 |
+
"species": "junii",
|
| 4 |
+
"full_name": "Acinetobacter junii",
|
| 5 |
+
"clinical_significance": "A less pathogenic species compared to A. baumannii. Often isolated in neonates and immunocompromised patients, causing bacteremia, meningitis, and wound infections. Generally more susceptible to antibiotics.",
|
| 6 |
+
"phenotype_profile": {
|
| 7 |
+
"morphology": "Gram-negative coccobacilli; may appear slightly longer than baumannii.",
|
| 8 |
+
"culture": "Smooth, moist colonies on blood agar. Non-lactose fermenting on MacConkey agar.",
|
| 9 |
+
"biochemical": [
|
| 10 |
+
"Oxidase negative",
|
| 11 |
+
"Catalase positive",
|
| 12 |
+
"Non-fermenter",
|
| 13 |
+
"ONPG negative",
|
| 14 |
+
"Does not grow in 6.5% NaCl",
|
| 15 |
+
"Non-motile",
|
| 16 |
+
"Does NOT grow at 44°C",
|
| 17 |
+
"Weak or absent glucose oxidation"
|
| 18 |
+
]
|
| 19 |
+
},
|
| 20 |
+
"differentiation": {
|
| 21 |
+
"from_close_species": [
|
| 22 |
+
"Does not grow at 44°C, unlike A. baumannii.",
|
| 23 |
+
"More antibiotic susceptible than A. baumannii.",
|
| 24 |
+
"Colony morphology more moist and less adherent.",
|
| 25 |
+
"Genetic identification required for reliable distinction."
|
| 26 |
+
],
|
| 27 |
+
"from_other_genera": [
|
| 28 |
+
"Oxidase negative non-motile phenotype differentiates from Stenotrophomonas and Alcaligenes.",
|
| 29 |
+
"Coccobacillary morphology may mimic Neisseria, but oxidase negative result rules them out."
|
| 30 |
+
]
|
| 31 |
+
},
|
| 32 |
+
"confirmation_methods": [
|
| 33 |
+
"MALDI-TOF MS",
|
| 34 |
+
"16S rRNA sequencing",
|
| 35 |
+
"Inability to grow at 44°C (supports species assignment)",
|
| 36 |
+
"Genome-based identification for high accuracy"
|
| 37 |
+
],
|
| 38 |
+
"treatment_notes": "Typically susceptible to more antibiotics than baumannii. Standard beta-lactams, fluoroquinolones, and aminoglycosides may be effective.",
|
| 39 |
+
"notes": "Commonly isolated from neonatal intensive care units; pathogenicity lower than baumannii but still clinically relevant.",
|
| 40 |
+
"references": [
|
| 41 |
+
"Manual of Clinical Microbiology.",
|
| 42 |
+
"NICU infection surveillance literature."
|
| 43 |
+
]
|
| 44 |
+
}
|