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README.md
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---
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# Liver Cell Biology Research Group(LIVR)
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Brussels Health Campus • Vrije Universiteit Brussel • Brussels • Belgium
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## Other Links
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* LIVR-VUB Hugging Face: [](https://huggingface.co/LIVR-VUB)
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## Continers for HPC (Only for LIVR members)
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When running large analysis or a custom program on HPC, its very important to run them containerized. Using containers prevents dependency conflicts and avoids issues that can arise from broken or mismatched software environments on the HPC.
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* Currently we support both **Singularity**  and **Docker** [](#) conatiners.
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* **Important:** On VSC clusters, only Singularity/Apptainer containers can be executed.
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* All of our custom containers are stored in **Pixiu** under the collection **LIVR-Containers**. If you need access to the the LIVR-Containers collection contact Arka.
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## Mission
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Advance understanding of liver cell diversity, regeneration and fibrosis to drive novel biomarkers, in vitro disease models and therapeutic strategies for chronic liver disorders.
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---
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## Research Objectives
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- **Cellular Characterization**
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Profile healthy vs. diseased liver cell types at single‑cell resolution.
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- **Fibrosis Mechanisms**
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Dissect pathways of hepatic stellate cell activation, fibrogenesis and resolution.
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- **Biomarker Discovery**
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Identify stellate‑cell‑specific markers for non‑invasive fibrosis staging.
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- **Disease Modeling**
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Build iPSC‑derived liver cell co‑cultures and organoids to recreate MASLD and other chronic conditions.
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- **Regeneration & Progenitors**
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Elucidate the role of liver progenitor cells in tissue repair.
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---
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## Key Collaborations & Networks
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- **ImAgE‑D** (Marie Skłodowska‑Curie ITN, Oct 2023 – Sep 2027)
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High‑speed, super‑resolution imaging of endothelial and liver cells.
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- **DeLIVERy** (EIC Pathfinder, May 2022 – Apr 2026)
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Personalized polypharmacy testing on patient‑derived mini‑livers.
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---
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## Publications & Resources
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- **Latest Publications**
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- *JHEP Reports*: “HSC single‑cell atlas reveals activation across etiologies”
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- *Biofabrication*: “iPSC‑derived liver spheroids to model fibrosis”
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- *Science*: “Hippo signaling instructs ectopic organ growth”
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- **Full Publication List:**
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Browse all [publications (2010–present)](https://pubmed.ncbi.nlm.nih.gov/?term=van+Grunsven+L&sort=date)
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Research Portal [Click here](https://researchportal.vub.be/en/organisations/liver-cell-biology/publications/).
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---
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## Team & Training
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- **Current Members** | **Former Members**
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Explore profiles and roles on our [Team page](https://livr.research.vub.be/livr-members/livr-members).
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- **Doctoral & Post‑doc Training**
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Interactive workshops, imaging courses, and 3R‑principle seminars for early‑career researchers.
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---
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## News & Events
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- **Belgian Stem Cell Meeting** – Nov 28 2025 @ ULB Erasme Campus
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- **Upcoming Seminars** & “Film Nights” showcasing 3R approaches and mini‑liver therapies
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- Follow live updates in [News & Events](https://livr.research.vub.be/news-events).
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---
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## Contact
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Laarbeeklaan 103, Building D – Room D022
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1090 Brussels, Belgium
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jmlazou@vub.be | +32 2 477 4409
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---
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> _“By unlocking liver cell biology, we pave the way for precision therapies in chronic liver disease.”_
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