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Role: You are a senior front-end engineer + interaction designer. Build a production-ready, accessible, fast scrollytelling website that explains a synthetic-biology system.
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| <title>Technical Notes - Synthetic Biology QC System</title> | |
| <meta name="description" content="Detailed technical documentation for the synthetic biology QC system"> | |
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| <h1 class="text-4xl font-bold text-blue-400 mb-8">Technical Notes</h1> | |
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| <h2 class="text-2xl font-bold text-blue-400 mb-4">System Architecture</h2> | |
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| <h3>Core Components</h3> | |
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| <li><strong>Dual Stress Sensors:</strong> σ32 (cytosolic) and σE/Cpx (envelope)</li> | |
| <li><strong>ProductionMode Gate:</strong> (Scyt ∨ Senv) ∧ PM logic</li> | |
| <li><strong>Actuator & Latch:</strong> Flp(ssrA) recombinase with FRT cassette</li> | |
| <li><strong>Translation Certificate:</strong> Ribosomal re-initiation mechanism</li> | |
| <li><strong>Antidote:</strong> Dual transcriptional and sRNA inhibition</li> | |
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| <h3>Partitioning Strategy</h3> | |
| <p>The system is divided between genome-integrated components (sensors, gate, actuator, latch) and plasmid-based elements (target protein, certificate, ProductionMode).</p> | |
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| <h2 class="text-2xl font-bold text-blue-400 mb-4">Implementation Details</h2> | |
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| <h3>Stress Pathway Integration</h3> | |
| <p>The system leverages native E. coli stress response pathways without requiring genetic modifications to the host chassis.</p> | |
| <h3>Quality Control Metrics</h3> | |
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| <li>Target enrichment: ≥10×</li> | |
| <li>False commit risk: ≤0.001</li> | |
| <li>ProductionMode threshold: tunable parameter</li> | |
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| <h2 class="text-2xl font-bold text-blue-400 mb-4">References</h2> | |
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| <li>σ32 heat shock response pathway</li> | |
| <li>σE/Cpx envelope stress sensing</li> | |
| <li>Flp/FRT recombination system</li> | |
| <li>Ribosomal re-initiation mechanisms</li> | |
| </ul> | |
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