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 timestamp_utc,session_id,first_name,last_name,question,answer,rating,comment
-2025-09-15T01:57:03.517513+00:00,50f50ee0-0bcb-4c1a-b1f8-3f9ed70da18c,Shubh,Laiwala,Mechanism of thyroxine hornone,"[LLM fallback — ungrounded]
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-Thyroid hormones play a crucial role in the development and maintenance of musculosketal systems, including bone metabolism. Thyroxin (T4) and triiodothyronine (T3) bind to thyroid hormone receptors (TRs) in osteoblasts, stimulating the expression of genes involved in bone formation and resorption, thereby promoting bone growth and remodeling. The thyroid gland secretes T4 and T3, which are transported to target tissues by thyroid-binding globulin (TBG), thyroid binding prealbumin (transthyretin), and albumin. In bone, thyroid receptores are expressed in ossification cells, chondrocytes, and osteoclasts. Thryoid hormones increase osteogenic differentiation of mesenchymal stem cells, enhance osteoprogenitor cell proliferation, and promote osteocalcin expression. They also inhibit osteo-clastogenesis and increase bone turnover. In addition, thyroids regulate the expression and activity of other growth factors, such as IGF-1 and BMPs, and",2,
+2025-09-15T15:39:35.937361+00:00,18d7d836-9d64-4cb7-ab69-6aa252b1bc76,Gaia,Dupont,How does sterilization of dECM influence mechanical properties of dECM gels?,"Answer: Sterilization methods can significantly affect the mechanical properties and biological activity of dEM. For example, gamma irradiation can lead to crosslinking of collagen fibers, altering its mechanical properties, while ethylene oxide can cause denaturation of proteins and loss of bioactivity. Therefore, it is essential to optimize the sterilizing conditions to minimize these effects and maintain the structural integrity and biological function of the dECMs. In addition, the use of additives such as antimicrobials and preservatives may further impact the mechanical and biological properties of the final constructs. The choice of sterilized method depends on the specific application and desired outcome. For instance, gelling agents like alginate and gelatin methacrylate can be used to enhance the mechanical strength of dEBM hydrogels, while preservatives like glutaraldehyde can improve shelf life but reduce cell viability. Ultimately, the optimal balance between sterilizability, mechanical properties (e.g., stiffness, viscoelasticity), and biological functionality must be achieved for effective tissue engineering applications.",5,