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| title: DNA CASINO | |
| emoji: 🧬 | |
| colorFrom: green | |
| colorTo: blue | |
| sdk: gradio | |
| sdk_version: 5.35.0 | |
| app_file: app.py | |
| pinned: false | |
| license: apache-2.0 | |
| short_description: DNA Diffusion | |
| models: | |
| - VIDraft/Gemma-3-R1984-27B | |
| - VIDraft/Gemma-3-R1984-12B | |
| - VIDraft/Gemma-3-R1984-4B | |
| 🎰 DNA CASINO: Hit the Genetic Jackpot! 🧬 | |
| 🎲 When Biotech Meets Vegas = ?? | |
| Hey there! Today I'm thrilled to introduce something truly extraordinary. We've transformed DNA-Diffusion into a full-blown casino slot machine - welcome to DNA CASINO! 🎊 | |
| 🎯 What's This All About? | |
| 🧬 Generate 200bp DNA Regulatory Sequences: AI-powered generation of cell-type specific synthetic biology sequences | |
| 🎰 Slot Machine UI: Watch each nucleotide (A,T,C,G) spin like real casino reels! | |
| 🔬 Real-time Protein Analysis: Instantly translate generated DNA to protein and get AI-powered structure/function analysis | |
| 💫 Key Features | |
| 1️⃣ Choose Your Cell Type (Like Casino Chips!) | |
| 🟢 K562 - Leukemia cell line | |
| 🔵 GM12878 - Lymphoblastoid cell line | |
| 🟡 HepG2 - Liver cancer cell line | |
| 2️⃣ Pull the Lever to Begin! | |
| Just like a real slot machine - pull the lever or hit SPIN and watch 200 nucleotides whirl in spectacular fashion! 🎪 | |
| 3️⃣ AI-Powered Protein Analysis | |
| DNA → Protein translation | |
| Structure/function prediction via vidraft/gemma-3-r1984-27b (ranked #2 in medical reliability on FACTS Grounding Leaderboard) | |
| Cell-type specific insights | |
| 🛠️ Tech Stack | |
| python🎨 Frontend: HTML/CSS/JS (Pure vanilla goodness!) | |
| 🧠 Backend: Gradio + DNA-Diffusion model | |
| 🤖 AI Analysis: vidraft/gemma-3-r1984-27b | |
| ⚡ GPU Acceleration: Hugging Face Spaces GPU | |
| 🎮 How to Play | |
| Pick your cell-type chip 🎯 | |
| Pull the lever or hit SPIN! 🎰 | |
| Watch your DNA sequence generate ✨ | |
| Check out the protein analysis 🔬 | |
| 🌟 What Makes It Special | |
| Immersive casino theme: Neon lights, glowing effects, and that iconic 777 lever! | |
| Scientific accuracy: Real codon tables, precise protein translation | |
| Educational value: Learn DNA-protein relationships the fun way | |
| 🚀 Try It Now! | |
| [VIDraft/DNA-CASINO](https://huggingface.co/spaces/VIDraft/DNA-CASINO) | |
| Baed LLM Model: VIDraft/Gemma-3-R1984-27B | |
| Powered by VIDraft | |
| Based theory by 'pinello lab' | |
| ## Citation | |
| If you use this application in your research, please cite: | |
| ```bibtex | |
| @article{dnadiffusion2024, | |
| title={DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements}, | |
| author={DaSilva, Lucas Ferreira and Senan, Simon and Patel, Zain Munir and others}, | |
| journal={bioRxiv}, | |
| year={2024}, | |
| doi={10.1101/2024.02.01.578352} | |
| } | |
| ``` | |
| ## Links | |
| - [GitHub Repository](https://github.com/pinellolab/gradio-dna-diffusion) | |
| - [DNA-Diffusion Paper](https://www.biorxiv.org/content/10.1101/2024.02.01.578352v1) | |
| - [Pinello Lab](https://pinellolab.org) |