README.md

---
title: ProtoBind Diff
emoji: 💊
colorFrom: yellow
colorTo: gray
sdk: gradio
sdk_version: 5.35.0
app_file: app.py
pinned: false
license: mit
short_description: Structure-free target-specific molecule generation
---

## A Structure-Free Diffusion Language Model for Protein Sequence-Conditioned Ligand Design

<a href="https://www.biorxiv.org/content/10.1101/2025.06.16.659955v1">
    <img
      src="https://img.shields.io/badge/bioRxiv-paper-blue?logo=biorxiv&logoColor=white"
      alt="Paper on bioRxiv"
    />
  </a>
<a href="https://github.com/gero-science/ProtoBind-Diff">
    <img 
      src="https://img.shields.io/badge/GitHub-code-black?logo=github&logoColor=white"
      alt="View on GitHub"
    />
</a>

## Citation

```bibtex
@article {Mistryukova2025.06.16.659955,
	author = {Mistryukova, Lukia and Manuilov, Vladimir and Avchaciov, Konstantin and Fedichev, Peter O.},
	title = {ProtoBind-Diff: A Structure-Free Diffusion Language Model for Protein Sequence-Conditioned Ligand Design},
	year = {2025},
	journal = {bioRxiv}
}
```

## License 
The code and model weights are released under MIT license. See the [LICENSE](LICENSE) file for details.