README.md

metadata

title: BloomOne
emoji: 🧬
colorFrom: blue
colorTo: purple
sdk: gradio
sdk_version: 5.31.0
python_version: '3.12'
app_file: app.py
pinned: true
license: apache-2.0
short_description: AI-powered personalized neoantigen mRNA vaccine design

🧬 BloomOne

Personalized Neoantigen Vaccine Pipeline — powered by Gemma 4 12B

Transform tumor DNA into personalized mRNA neoantigen vaccine constructs through a 7-stage computational pipeline, orchestrated by an AI assistant.

Pipeline Stages

1. Data Ingestion — Fetch mutations from TCGA/cBioPortal
2. Mutation Calling — Strelka2 somatic variant calling
3. Peptide Generation — 8-11mer mutant peptide candidates
4. HLA Binding Prediction — MHCflurry/NetMHCpan
5. Safety Filter — Remove self-matching peptides
6. Candidate Ranking — Score by binding + VAF + expression
7. mRNA Design — Codon-optimized vaccine constructs

⚠️ All outputs are for RESEARCH USE ONLY. Not validated for clinical use.