docs/LIMITATIONS.md

Project Limitations

Variant Risk Explainer is an AI/ML research demonstration only.

Key limitations:

• The model is trained on DNA sequence patterns only.
• The prediction does not include full clinical evidence.
• The prediction does not include family history.
• The prediction does not include population frequency.
• The prediction does not include functional studies.
• ClinVar labels can be incomplete, conflicting, biased, or updated over time.
• Model performance is limited, with AUC ROC around 0.5928.
• The model may not generalize to variants outside the training distribution.
• The system is not for diagnosis or treatment decisions.
• The project is intended only for AI/ML research demonstration and education.

Any real genetic or medical decision requires validated clinical testing, clinical databases, and review by qualified clinical genetics professionals.