README.md

metadata

title: TSA Shiny Agent
emoji: 📊
colorFrom: blue
colorTo: green
sdk: docker
app_port: 7860
pinned: false
license: mit

TSA Shiny Agent

Trial Sequential Analysis with AI Assistant

A modern R Shiny web interface for Trial Sequential Analysis (TSA) with an integrated Claude AI assistant.

Features

• Meta-Analysis: Fixed and random effects models (DerSimonian-Laird, Sidik-Jonkman)
• Effect Measures: Odds Ratio, Relative Risk, Risk Difference, Mean Difference
• TSA Boundaries: O'Brien-Fleming, Pocock, Haybittle-Peto alpha spending
• Visualizations: Z-curve plots, Forest plots, Funnel plots
• AI Assistant: Claude-powered chat for statistical guidance

Architecture

┌─────────────────────────────────────────────────────────┐
│                   Docker Container                       │
│                                                          │
│  ┌─────────────┐                      ┌──────────────┐  │
│  │  Shiny App  │◄────── rJava ──────► │   TSA.jar    │  │
│  │  (port 7860)│                      │  (Java)      │  │
│  └──────┬──────┘                      └──────────────┘  │
│         │                                               │
│         │ HTTP                                          │
│         ▼                                               │
│  ┌─────────────┐     localhost:8000   ┌──────────────┐  │
│  │ Agent Chat  │◄───────────────────► │ Plumber API  │  │
│  │  (Claude)   │                      │  (R Bridge)  │  │
│  └─────────────┘                      └──────────────┘  │
└─────────────────────────────────────────────────────────┘

Usage

1. Create Meta-Analysis: Set effect model and measure
2. Add Trials: Enter dichotomous or continuous trial data
3. Calculate Boundaries: Configure TSA parameters
4. View Results: Interactive graphs and statistics
5. Ask AI: Get explanations and guidance

Environment Variables

Variable	Description	Required
ANTHROPIC_API_KEY	Claude API key for AI chat	Optional

Local Development

# With Docker
docker-compose up

# Without Docker
./start_tsa.sh

Credits

• TSA algorithms: Copenhagen Trial Unit
• AI: Claude by Anthropic
• Framework: R Shiny + rJava