giovp/dataset

README.md

@@ -20,10 +20,10 @@ SigSpace
 
 ## Members
 
-- Ishita Mangla - ishi.mangla@gmail.com
+- Ishita Mangla - Lila Sciences - imangla@stanford.edu
 - Giovanni Palla - Chan Zuckerberg Initiative - gpalla@chanzuckerberg.com
 - Rohit Khurana - Stanford - rkhurana@stanford.edu
-- Siddhant Sanghi - UC Davis - ssanghi@ucdavis.edu
+- Sid Sanghi - UC Davis - ssanghi@ucdavis.edu
 - Kuan Pang - Stanford - kuanpang@stanford.edu
 - Yanay Rosen - Stanford - yanay@stanford.edu
 - Yasha Ektefaie - Harvard - yasha_ektefaie@g.harvard.edu
@@ -47,22 +47,6 @@ Specifically:
 - JUMP: We use the JUMP dataset, which captures morphological profiles of cells in response to chemical and genetic perturbations. High-content imaging and automated feature extraction are used to quantify cellular changes, enabling large-scale profiling of perturbation effects across diverse biological contexts.
 - UCE-CXG-EMBEDDING: natural perturbation search using AI virtual cell.
 
-## Data
-The following datasets are used in our project:
-
-- **drug_metadata_inchikey.csv**: Drug metadata from Tahoe-100M including InChIKey identifiers for chemical structure representation.
-- **compound_genetic_perturbation_cosine_similarity_inchikey.csv**: Cosine similarity scores between compound and genetic perturbations in Jump dataset.
-- **Tahoe_PRISM_cell_by_drug_ic50_matrix_named.csv**: IC50 values showing drug sensitivity across cell lines.
-- **filtered_results.csv**: Filtered NCI60 LC50 data for drug response analysis.
-- **cell_line_metadata.csv**: Comprehensive metadata for cell lines in the Tahoe dataset.
-- **drug_metadata.csv**: Detailed information about drugs in the Tahoe dataset.
-- **tahoe_vision_scores.h5ad**: Vision scores in AnnData format capturing cellular morphological changes.
-- **Tahoe_PRISM_matched_cell_metadata_final.csv**: Cell metadata for PRISM-Tahoe matched cell lines.
-- **Tahoe_PRISM_matched_drug_metadata_final.csv**: Drug metadata for PRISM-Tahoe matched compounds.
-- **in_tahoe_search_result_df.csv**: Search results for perturbations within the Tahoe dataset embedded with UCE.
-- **cxg_search_result_df.csv**: Cross-dataset search results using CXG embeddings with UCE.
-
-
 ## Results
 
 We have developed a Gradio application that accesses these databases and performs complex queries, enhancing and grounding the reasoning in real biological measurements.

agent/agent.py

@@ -16,9 +16,8 @@ class SigSpace(Basic_Agent):
         self.conversation = []
         self.conversation.append({"role": "system", "content": self.system_prompt})
         
-        # initialize data path
-        # path = pathlib.Path("/home/ubuntu/giovanni/code/Tahoe_Hackathon/datasets") # on lambda
-        path = pathlib.Path("data")
+        # initialize data for jump
+        path = pathlib.Path("/home/ubuntu/giovanni/code/Tahoe_Hackathon/datasets")
         # jump_path = pathlib.Path("/home/ubuntu/giovanni/data")
         self.jump_tahoe_drug_metadata = pd.read_csv(path/"drug_metadata_inchikey.csv")
         self.jump_similarity_score = pd.read_csv(path/"compound_genetic_perturbation_cosine_similarity_inchikey.csv")

data/Tahoe_PRISM_cell_by_drug_ic50_matrix_named.csv

@@ -1,44 +0,0 @@
-depmap_id,5-fluorouracil,AT-7519,AZD2858,AZD5363,AZD8055,BI-78D3,FG-4592,GDC-0068,KD025,LGX818,LY2090314,MEK162,MLN0128,NVP-BHG712,PI3K-IN-2,PP242,TAK-733,TAK-901,abemaciclib,acetazolamide,afatinib,alpelisib,altretamine,amsacrine,artesunate,aspirin,azacitidine,baicalin,belinostat,bendamustine,betamethasone-dipropionate,bexarotene,bicalutamide,bortezomib,busulfan,ciclopirox,cinacalcet,clobetasol-propionate,clofarabine,clotrimazole,cobimetinib,crizotinib,crizotinib-(S),cyclosporine,dabrafenib,decitabine,digitoxin,dihydroartemisinin,dinaciclib,docetaxel,drospirenone,eplerenone,erdafitinib,erlotinib,everolimus,filgotinib,flutamide,fulvestrant,gefitinib,gemcitabine,glasdegib,harringtonine,hexylresorcinol,homoharringtonine,hydroxyurea,idoxuridine,irinotecan,ivermectin,ixazomib,lonafarnib,mebendazole,meloxicam,menadione,methotrexate,mifepristone,mozavaptan,naproxen,neratinib,olaparib,omeprazole,oxaliplatin,oxyquinoline,paclitaxel,palbociclib,panobinostat,pemetrexed,penfluridol,pentagastrin,ponatinib,posaconazole,raltitrexed,regorafenib,ribociclib,selinexor,sirolimus,sonidegib,sunitinib,temsirolimus,terfenadine,trametinib,tranilast,triamcinolone,trifluridine,tucatinib,ubenimex,uridine,vandetanib,vemurafenib,venetoclax,vincristine,vismodegib,volasertib
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-ACH-000396,1.93645121742948,1.6431807362905246,1.47034383788847,2.44449480866131,0.141921706383846,2.74548313097217,,,1.97583918167743,,1.19908560389337,2.0356191805503,0.0461069917935358,7.26775925634942,0.832835615955698,1.31714533819714,0.42885007570464,0.759633276609733,1.6098265469647708,,,,,,,,4.24803913685048,,1.1762165653798151,,,,,0.2509862924195815,,1.66544298359318,4.780174009295996,,0.14029527315787,,2.41182376655551,3.2805890869580527,1.65151902634263,,5.73312864554334,0.9408408045250529,0.147917011802461,,0.189790417293454,0.01223960930708345,5.95033598371184,2.34506928650052,,0.896963331573109,119.84074425597731,,,,3.95807307970834,0.003775502523254,,0.233041495455509,,0.1478425214866176,1.74228733601486,,0.24999325646806694,,0.0409708850045547,1.73306490990459,0.859101864415519,,5.49378974437061,0.11794065820054911,3.79607820696219,4.85879882679396,,1.72012988868823,3.48405232907738,6.78392716060108,0.749328646487044,6.49639992781623,0.0138806249039502,,0.01491922152446605,3.4630254193142345,0.62023677780973,,2.243979823656919,,0.0395340627489771,,3.38205747642875,0.1204399820696176,0.0093036484865859,,5275.69346179515,0.00631791180616675,,2.03764019600628,0.830923787704173,,0.441865195775647,,,,,,,0.0255232036560735,5.71609740384236,0.07683146375041465
-ACH-000437,1.02849387109899,1.6688647544418092,1.00882265615278,2.25147434095137,0.108042167003782,4.09083366637824,,,2.18311084333299,2.49734377151988,1.52038594464591,5.3858738368531,0.0577160310860252,,2.19992224209795,1.82805370527729,0.416994780488975,0.34368105381217,3.5092649045742963,,5.67404201253046,,,0.218881628192773,,,23.8654260165347,0.846380111149414,1.0971346244819085,5.52925392510299,,,,0.0144904592022002,4.64752706015357,0.901483432564622,3.6225579868943,,0.147482912779914,,0.178196178593731,3.754768483460379,0.836073656775767,,1.45947543635029,0.33197065929833736,0.0795787601905483,,0.14347138767730502,0.00668666586284205,,2.40964155066309,,1.0109462919583,0.0826900308850482,,,,5.63384765774877,0.000549833767872125,,0.287298048677163,2.00824365841619,0.462586123264359,1.06201674369083,1.22233200684854,0.3840515395695804,3.87304683108971,0.0483914921828725,0.437998481085189,1.60502478985437,,3.80937265968505,0.18291067480829828,7.14673178319067,6.62789587459821,,1.96385146441171,6.820863631527357,,1.85325915517502,7.895258188183375,0.0059752404919532,4.486642180140305,0.06583736138538171,2.777013342197447,0.973492142615697,,1.4872783964152037,,0.026643890212963,,1.76402377800909,0.24592046572452556,,5.04921393373566,4.517452708801772,0.0020872681012427,5.30800629033114,0.8970781037690634,1.21400318653208,,0.191445509598093,,,,,,,0.239212098597989,,0.10393061570705675
-ACH-000463,1.99403129284221,0.4726198394811546,1.75380587330001,2.06346859791476,0.112934553422745,2.23638500640637,,3.072760637643645,2.16177632654002,,2.98382509812103,0.783243456618271,0.02130628318575605,8.26248823016427,0.134547545830591,0.58056862397406,0.282669924602617,0.311808628903585,0.5832698889508046,,3.06061558503666,1.4717126499953153,,0.0778917586327192,6.61889271911539,,4.877675179012967,6.6184548689529,0.7217188401986396,6.49426970785163,,,,0.0210089630639219,2.50751370614966,1.55279218895342,4.467798826800961,,0.425995075926361,,0.4620482071665535,2.0209438282572285,2.40340005663243,,4.19759774115585,0.3510428392738057,0.111341081412471,,0.418061272859328,0.0335040817327916,3.06723618171372,2.48399990404227,,3.13519316840028,0.0363416421044493,,,,5.64318404142044,0.000935933113728644,,0.164369827015895,,0.06651968663129874,4.08999138904399,1.40165695083202,0.37673662497197624,3.93012265244049,0.0807737682821252,0.366740195553243,1.71153188586651,3.54507624571047,6.61817932461597,0.058400076502735446,2.53034016212653,5.847623861230965,,5.251235470131388,4.059094808485522,,0.586059225018828,8.101593398975835,0.00842812824205605,0.631627482502908,0.07603709917354196,1.4342000101495698,0.521539001194979,,1.7013560004777721,,0.0246040626122548,5.67386080066764,1.16598862350899,0.2848302241882975,0.0118675985927808,,2.158751217077877,0.0026493803823975,6.75381568206931,0.3869602398613998,2.12901122771606,2.76373447458752,0.122479325213348,,5.5385573860925,,,,,0.0484300658920239,8.59467476425374,0.04939463400234135
-ACH-000493,2.37178089229985,3.3022365745950855,2.06662057229731,3.24941066159506,0.115857178467513,2.90608265869834,,,2.17787741168932,,,0.925532017748069,0.033297058114792055,,0.985887947289669,1.02164859638299,1.58647802078009,0.445902088922998,1.0244710572846683,,4.93054564634905,3.22363563965736,,0.270722237987922,,,9.244128361239058,5.65031535059223,0.8389267014893635,6.77175524721402,2.04213336217388,,,0.01294946792425135,,1.63358695193315,6.753370268756365,,0.460773730831245,,2.08310178385977,3.2589803576510996,1.15847388795991,,2.16212666382682,0.4142739366407474,0.1113123820811,,0.1277502169968256,0.0049570300851563345,,5.7364479772923,9.18154918042138,2.04491085024201,6903.431262234846,,,,7.709808692135347,0.000686411094277283,,0.191915515540781,,0.507532094091784,,2.12526588578125,0.14864235555639466,3.65636207403184,0.0827237486319922,1.40200686810791,1.06284150502609,,3.1315008942949,0.2309855181712668,6.00306386810637,2.9678981985638195,,4.122682526130458,3.513760091514451,,,8.740489306914316,0.00561937266549325,1.0056764153578666,0.054601625390320756,2.262102878761901,0.606342072183372,6.78171936662026,1.6860310495186037,,0.0299154195524392,,,0.13864119723994242,0.0164386467231606,,8.737928885739397,0.00045054192256247113,5.69396614347532,0.7480328170160421,1.22431623462125,,0.234953488947565,,,,8.721449362270866,,,0.0150951211460278,,0.11037063747097381
-ACH-000496,2.1468570689806,1.8223604872180872,0.63928011139623,,0.121426786423287,5.47852258053291,,,1.80502196341424,,0.0195551576340802,0.321589221841779,0.01410599678590085,,0.595757380923407,0.491947075826837,0.603978354750655,0.566441407427733,0.7807007508709181,,5.88250440522791,,,0.116580766448221,,,1.944558296173803,3.91379788093151,0.6005039149063277,,,,,0.0344788538704907,3.24102103150651,1.08936189394386,0.79834956349582,,0.40218293628757,,0.6735088027376203,5.4342278684803835,2.62847272355451,,3.62103753747046,1.174220785731779,0.0634342029500668,,0.07721873304846301,0.057018841397000045,3.56331458779379,0.907056513490473,,6.399640988152071,,,,,1.97909019024474,,,0.244868932852988,,0.2099308315637531,1.25718144926217,,0.3671004458215743,,0.152416506490883,0.504183903442237,1.07520852183401,,3.9531479729955,0.152853556111942,4.38493971061811,6.90488534278407,,,1.8052953915728311,6.23312340067478,2.90660807765553,4.835234721604801,0.02197586160265065,,0.05814730748535275,,0.381209101300545,,1.164661274154128,,0.0449105429269842,,,0.2800948780877265,0.0266180714625115,,,0.0969720789166341,3.17802305425697,0.0739047722621572,1.22011061844787,,0.221727736608573,,,,,,11.0342437561794,0.0805623535460507,4.62375080068222,0.02512538908204175
-ACH-000521,2.46984120092955,3.1211076023935354,2.13284902197502,8.12158355751326,0.127251524340125,3.05449692628554,,,2.15711363692825,1.1999048674705,,0.942898346278657,0.015769110673602,5.58823058490271,0.371612763211063,0.776950482951618,0.311271659881679,0.615315928771594,1.8145855090606577,,2.98320992748608,7.756029306611927,,0.109185734532949,4.97732072235063,,9.12970365885877,5.85439511892586,1.66267353578433,7.70715440669138,2.86939301914611,,,0.0167178162252214,,1.30515213083805,7.018286554554128,,0.568969320088898,,0.678577778821683,2.23217827690512,1.53132451053091,,0.952001641828754,0.9618881024235055,0.12040746963035,,0.339918700202873,0.013733528662877751,4.13802195122624,2.04842827407615,6.98609628753586,2.167885582686807,0.0970077638140509,,,,6.620204433647135,0.000170219301080079,,0.230625369985494,,0.3460087723876992,3.39328934553916,4.01695886279394,0.3256161201523557,5.29721581971744,0.559837534161075,0.830399165089627,1.94391969592971,7.60214017314271,2.29256317144861,0.1528160410721954,4.0828793476584,7.09516356227215,,2.581787751543627,4.1127467682151115,,3.10560324024929,9.03384559658376,0.0063841145450912,1.063480173617722,0.0689402637857059,2.7391326363627435,0.891490910302176,,1.4118234567082695,12.9599211860878,0.0904608887780622,,1.94654980921931,0.24479952679720368,0.00059013828015103,,5.4482011609297,0.0007295819463223225,5.05926297653106,0.31084769897165915,1.91655167228092,,0.329633326620927,,7.04712000864782,,4.761613191045109,,,0.143131731676747,,0.1540710977622914
-ACH-000552,1.38420772980826,3.2877597343715634,2.7712539990662,3.03931867818738,0.733150227291681,3.89330749187338,,,,,4.96190931252693,0.229439851763134,0.2794994965291564,4.6307728841603,2.7477203041328,2.39272885880339,0.137425657562161,0.623239115619823,0.993612120543221,,2.69488039473449,1.21241839924425,,0.323283527866248,,,6.18618417347466,,0.744895813669077,,1.53544868915128,,,0.0118849981402299,,1.89895266183048,,,0.530980808704835,,0.22747843775824275,,1.88213210688416,,0.329934234378031,1679.63301416414,0.141567021635133,,0.424470283172686,0.05572297458754975,4.79664671909574,3.13235978863522,,,,,,,5.718162575126389,0.0032179205633734,,0.368589385758901,1.68977897009686,0.5560114556197773,6.51492308863813,,1.42573358772416,,0.104509863068221,1.91266178797314,2.00879258384453,,6.11736138939801,0.23493787558015544,,5.49744039522479,,1.42546960919298,,2.54188495182994,5.43721249705145,0.517400789756911,0.0091859483699888,5.269245865232475,0.06962781378385666,1.7837460944840136,1.48993905604755,0.0443590898762066,2.34490447230444,,0.0266359415760943,3.08150984095804,,0.34223718585198754,2.6639530470587,,7.501546488837209,1229282.00679214,4.17391054452942,0.06183345981087375,1.31164674305085,,0.397382888213736,,,,9.996585183699498,9.531727390876842,,0.0158726182039523,,0.0470902191292263
-ACH-000555,,1.1571712154659253,,,,,,,,,,,0.0068653755379825,,,,,,1.5784462684391205,,,,,,,,,,2.600097390007057,,,,,0.004010130035379,,,,,,,,2.7027239968533316,,,,0.1663852688849944,,,0.0324153291970798,0.0120965299913157,,,,,,,,,9.785904761236091,,,,,0.0443193830627116,,,,,,,,,,0.0198830572983752,,,,6.909961405203729,,,,,0.0117442546135299,4.233901650520055,0.0750039458832274,,,,1.4997674246464645,,,,,,,,1.442825969063774,,,0.861763207293211,,,,,,,9.818521759447693,,,,,0.5425537795549785
-ACH-000558,2.74087993547356,1.7271932636121723,2.53259703830762,,0.791289416160682,2.54064596661564,,,3.47239674968815,,0.138772524749716,2.51266528907598,0.054304380789313655,4.95437822791626,3.66696870104127,3.65692390267909,1.92931762738544,0.464973591901245,2.803551440413,,2.03239241584382,,,2.30909189421988,,,,8.29849407827526,2.0066710179514136,,,,,0.0090752852475438,2.5636436491708,2.3909790162691,5.2218578428950355,,0.724328057142571,,0.948522205748555,2.458094395674821,2.04493258571644,,1.25418815088675,,,,0.11778061777993525,0.01699215302740715,1.06644816147041,4.15942380282451,4.9679907949142,,0.040248070476712,,,,,7.99445196785308e-05,,0.206010353349331,,0.1781533678279362,,,,0.478827883821887,0.0357385328833135,,,,4.26422813092778,0.2420851334431064,,,,1.31961513912853,,,0.389708303301976,5.55523203251702,0.0086353020397033,,0.056919935652269354,6.923528102338639,0.766340510578728,,1.54437999674131,,0.417485629849586,,,0.059384365211474596,1.10386841804747,,9.55161386969951,0.23719859036556432,2.88280610818663,0.9537696132744871,1.88725664715444,,0.946042065394907,,,,,,,0.113845902073352,,0.7251005961597059
-ACH-000580,,0.1327898684233213,,,,,,,,,,,0.0101125803428855,,,,,,0.4073370485505989,,,,,,,,7.190676560891556,,0.506516794154616,,,,,0.0091956835062586,,,3.639503928780257,,,,0.0107954941008447,2.1901158200748574,,,0.0086622684172723,0.1684986631884947,,,0.0095038021636798,0.0019248938098636,,,,8.803949561812699,,,,,,,,,,0.048478923469169,,,0.0453577354362608,,,,,,,0.0034120475175316,,,,3.5252726531784027,8.23507659712562,,,,,0.4904428406804503,,1.4709653858627003,,,0.3670024361566182,,,,4.532637167986354,,,6.681960109548405,,0.00023369550214290017,,0.0060728585337769,,,,,,,8.894111924230172,0.4120585658442843,,,,
-ACH-000601,2.78112909247536,0.3885141255967653,1.97746263630102,7.44910881650089,0.183485434949236,2.15661082649443,,,1.99219218170554,,1.62538829376672,0.0778707002112669,0.0364837787897595,6.59714919969099,0.883788619039224,0.756815558849184,0.0614864022022132,0.56472110336482,1.944111331844492,,0.754472340372214,,,0.163331743756973,,,5.770008485090465,6.26618006625656,0.1861859475213417,7.50895314817431,,7.87963247214434,,0.0347188243896844,0.0225417233278692,1.47461162463404,8.515632918327013,,0.588428098901324,,0.3041467048062983,1.96130902702417,1.57072618320089,,0.884794490882401,0.9398979495561356,0.114511401728025,,0.0215063574982227,0.0151587396602236,4.21648766686592,2.48879797843408,8.7146316739815,1.102507925109,,,,,3.04006220320978,0.005144556992463,,0.186073903619991,,0.07754898345650026,4.11544382156138,1.7907166319412,0.560301198756829,,0.0373106380467597,0.650166755400896,1.06351393430688,6.09424220750255,6.58659314212657,0.2113019394977497,3.58698443960933,5.028678534671245,4.9191956972286,1.01068777287608,6.644400962145023,,0.609361874609596,2.92646508325259,0.0054421088739480495,1.727565866620889,0.015661472736354348,1.459373214549405,0.645139792462647,,2.038849978900896,,0.0425023159366687,3.53003965304579,1.75733344397083,0.1062963175526159,0.191850863971022,,17.482798759392054,1.19896200849535,6.12545207789703,0.15979795138476494,0.889811008120934,,0.144621693215178,,,,23.34145162506,,11.0891361641972,0.0027765004784413,,0.0643309117376419
-ACH-000628,2.57362435416001,2.52289922764491,,2.39717517312943,,2.99285524918678,,,2.24759941986345,,2.34618581287653,1.17870710278359,0.0181775014150084,5.48375009028569,0.480835055868343,,0.19561854892538,0.880018941700914,9.623992511758686,,,1.227586183416144,,,,,,,0.6189836984503267,9.10007397989346,,,,0.0191290161949631,,0.923337970420624,8.824162072324267,,,,0.1426031677391117,7.735803203149152,,,,3.864669114643938,,,0.373387875787238,0.0026360178793514,9.80572425105567,2.60729959386106,11.221979747566,,0.0042097025991008,,,,1.08308726988003,0.0062945157920852,,,,,,,0.1081199733491399,4.05551102033534,0.37628416834115,0.848576715082174,,,6.40313683316048,,6.85566784709631,,,5.192696787279239,2.6308730600814014,,2.64819711086711,6.3941746182688,0.0036684781384225,,0.0168985942476434,4.448327950421183,0.781626493565023,,1.0755594010225957,,0.0494230175041664,,,0.2254225615293331,0.0061670482713235,,8.561511936614064,0.00803483109070575,,0.3021567264647145,0.940317909848447,,0.665949928135433,,,,5.06348741680431,,8.343486928394672,0.085449809604051,,0.020119269852003
-ACH-000669,,2.390670878554963,1.1765838318966,,0.446026521118962,3.64055179337435,,,5.53645377103352,,0.572943217086303,2.84055729343307,0.05702857021808535,,1.35087739158317,1.26078419129756,0.45658505363279,0.615767738353369,3.259484398718625,,1.33619494729984,6.437478631945023,,0.208326729485418,,4.44707442531596,,3.99396251386787,1.70839025353741,7.07342486400445,,,,0.01860957793134725,1.59038816128051,1.3990152529562,3.8464019550439104,,0.85095133687774,,0.2192653072678531,2.0898246794913766,1.15638224811382,,,1.611029423051431,,,0.02394322489467245,0.0356924640816839,1.55075660953182,0.975407075860074,,,0.0037283184562296,,,,,4.58842239185451e-05,,0.258101725216375,,0.2927877080576313,,,0.0372448532868889,1.21337999685829,0.0743417363403084,,,,,,9.1652594751701,,,,3.204910115968177,6.08415604155879,0.825415709639543,4.974058693018275,0.011098367378156,,0.5097432638691825,4.322742655659445,0.627287585034695,0.0016985125965294,2.7152452745414566,,0.0742703940822147,6.21976772044251,,0.4128328831018965,0.360515188140639,,,0.0047171657463537,0.860027185267239,0.41979226446613277,,,0.533903214827957,,,,,,,0.0336831653835812,,0.13537531832846736
-ACH-000681,2.73549480945282,3.9863909265739,,,0.245257215933152,2.31565564790961,,,,,,0.23480583123747,0.0531984125010829,,1.28844765731545,1.48819725656139,0.0301012163275009,0.574941031860889,2.512273510419251,,,,,0.0818501445152602,,,9.71079724616527,6.07996086816826,1.4881767997607842,,,,,0.01760063017440685,3.41594173232285,2.50769597705589,9.87311679204398,,0.354625516590073,,0.0854590576311559,2.2501860256907276,2.6334345166831,,6.10855196722216,0.908754495667359,0.0873061989732176,,0.16118318888814,0.0255191023558122,2.84373256803605,6.38765142645704,7.32769837845209,,0.0062383417891064,,,,,0.005176870524358,,0.30153844423425,,0.6506979615411372,7.13499107873581,,3.936482979357364,0.602213649956837,0.189449145519242,2.59136473177298,5.19801377730154,,8.05159225012295,0.666294262995604,,7.136111585566775,,5.68141842260065,,,0.816447360014396,5.6814674438626,0.011673599948468399,1.4889991299085572,0.08382218279613005,2.70495556482538,1.54690613839141,,1.1521218777946383,,0.121859674230616,,4.06351571958752,0.3458268932880536,2.75909178691329,,2.8037671858086544,1.3124570101786366,0.681262530026543,0.049736311899564956,0.77094773639892,,0.688074536689543,,,,,,,,3.1206683321717,0.2794174255829518
-ACH-000750,,0.3061062459035666,1.81854287096191,5.83750832876983,,1.91309780259151,,,,0.0106152385458906,,0.006889921267936,0.035491153332857,,0.727666832634362,1.12439087382941,0.0071340263008306,0.14798664101031,0.6270092010022762,,5.00881082687849,4.070543684772842,,0.121866834684091,,,3.3231465173873636,8.68633037405096,1.0109496228569284,,,,,0.022574828714886898,,0.341787751340291,6.679690921686992,,0.672645743735824,,0.0184207930012091,2.1174128875721188,2.85624836173389,7.59995483503949,0.0051880386849576,0.1337498764083459,0.364343899416187,5.77995937654591,0.17904613664230307,0.006140754295694949,3.61200576802822,2.93491756288299,,3.1666350114926973,0.0240593261627544,,,,,0.0158124978790726,,0.068442910549546,,0.0846406849714617,,3.16406869038572,0.18158486846812194,,0.120346702485706,,0.558283632590695,,2.31231563347421,0.206688005388457,,4.63774932700793,,5.943107655814913,2.8281693658352,,3.20243559368263,5.877887443429605,0.0044124079208702,1.109703951726759,0.0420165171633727,1.752974831963632,1.35099819402102,0.0088376884595428,0.4035250727822901,,0.473584754434477,2.31630250205389,5.796667830390565,0.44480959834098827,0.256960895568585,,1.604818444608526,0.0047850299098342,2.02690432795991,0.012137558994403351,1.27849446367831,,0.155874522346438,,,,9.394709457279449,0.226067833919303,,0.0014557069636522,,0.0167213803372568
-ACH-000757,,,,,,,,,,,,,0.0306134157633001,,,,,,0.9942724839333578,,,,,,,,,,0.3225048101110562,,,,,,,,4.278627292827034,,,,0.0441055514327221,2.0091619185389837,,,2.970334483759966,0.1148276227186379,,,0.0101884626409755,0.0019816856938099,,,,3.8286067362624663,0.3108445856704842,,,,,,,,,0.028382590666652,,,0.0495659013476716,,,,,,,,,,,3.176388532849224,,,,,0.0023562760285323,1.5883329837758535,0.0144997747789085,2.670239253119644,,,0.4766655100685714,,,,4.424063720371171,,,,4.680833277602249,0.0180330230577441,,0.0098169668097028,,,,8.927189459736695,,,2.5617030582444396,,,,,0.0148337223893711
-ACH-000790,,1.9974278849135552,,,,,,,,,,,0.1270842824635578,,,,,,2.7899540785038313,,,,,,,,,,2.234762538675485,,,,,0.0101080893437686,,,9.64267978100388,,,,0.0314752611794713,9.529885948828529,,,,,,,0.026982656628486,0.012160290364043,,,,,0.2274826956016861,,,,,,,,,0.1396556268016611,,,0.1781430740974504,,,,,,,,,,,,,,,,0.0485357603466141,,0.0372263370391885,,,,2.8690113945798834,,,,,,,,7.033838558215637,0.083499422182839,,0.2303597053740767,,,,,,,,,,,,0.0415475391799989
-ACH-000793,,0.1907362984665653,,,,,,,,,,,0.0133348142192734,,,,,,0.5996536749752538,,,2.1189587098173748,,,,,,,1.7463074486085532,,,,,0.0076327676420433,,,7.991088159529823,,,,0.169780931084631,2.804266820897785,,,6.091663098076641,,,,0.0103720856422169,0.0014827896786648,,,,9.389729469879954,0.0031669112875415,,,,4.387928530725668,,,,,0.2572748968468152,,,0.1027542664780889,,,,,,,,,,,6.139559932465157,,,,,0.002339755145551,1.735515420915852,0.0310218889279646,,,,0.032584657563636,,,,,,,,1.8817528120167415,0.0084392544341993,,0.0560772379442035,,,,,,,,,,,,7.954040474002161
-ACH-000842,,0.6561509012079111,,4.41831246279989,0.371055313002694,3.47298067692719,,,4.91218731641795,,5.53894237885981,0.128293054916523,0.14951697216359175,,2.89024762068784e-16,,0.143413035936379,0.724455688835081,,,,,,,,,3.63848238006302,6.35008599365458,1.7744103868522672,,,,,0.027554231880665497,,0.790574188901204,5.2207264300132055,,1.4365613093635,,0.2947294136997668,8.695545390766311,4.0634130702194,,,0.6698390362913964,1.06687830705825,,0.099544858963709,0.0254229959340624,1.38143191410386,2.01398011811364,,,,,,,,5.81634667364309e-05,,0.365730561756235,,0.441241821200204,,,1.09674896713615,,0.0309238474733063,6.84228550854692,,,5.67736658574488,0.09314589563328796,,,4.05568708761763,,,,3.26408913580124,7.03168842745268,0.01346423450620815,,0.09129654482934545,,1.25601082324145,,2.5159068409777054,,0.0588417215041717,,,0.1222838215509897,2.28476541833221,,4.905319351869595,0.613353051750989,,0.0393674936380201,1.79148846025757,,0.468960513683969,,,,,,,0.0076972385493664,,0.3679800291875889
-ACH-000853,2.60734611957527,1.6842238680003838,2.15175318308622,4.50688858616175,0.168876573677405,3.81752898061278,,1.53773361966489,0.837087647615235,,2.36704743629936,3.07838397914426,0.01786445666095125,3.55611089518367,0.437176667361699,1.87381925059574,1.90544967829205,0.474947848754799,5.583570562838117,,0.543042894853297,,,0.125344859982041,2.2543747518978,,11.0525323040338,7.40436263431618,1.06106138221869,,,,,0.0642187241496212,,1.51174156677773,9.470211260597043,,0.49544572978174,,3.90580147909863,2.9469065678927224,3.37542848468684,,,,0.121633724279093,,0.0290071972506872,0.010869563004073601,,2.20231394276299,,0.966566472752723,0.0033207213335401,,,,,0.000415185854603565,,,,0.0581015745545659,8.18619817387452,,0.3423128334548802,0.385343688377781,0.766593069729375,1.04674787355222,1.51314539727631,,2.72914355205424,0.64767925475913,4.78841216817698,3.48456113939416,,0.678462150462955,8.935770896101069,,1.58268266230162,5.88458612684769,0.0071826849151407504,1.18692975865802,0.0556586865201759,,0.392114779780891,,1.8316157811482394,,0.123850896680765,4.49053112077829,2.55112632466171,0.36818645612038836,,2.96339032685823,8.734629208090741,0.0014924121916444,3.1791574411013,,1.44599208064225,,0.385552217856578,,,,7.66862712277395,,,0.000974607720688766,,0.0510794746433041
-ACH-000875,2.78645466560437,1.6133362243935698,,2.61871551600031,0.0374443505253684,2.59299974774944,10.9718035159652,,0.79083589835187,3.04420490459346,2.69098202106555,0.186571506746538,0.00538097390778965,3.71757098965787,0.154588075763351,0.344378668500911,0.0251605292094975,0.261599502987949,0.26742463402536404,,2.26083644295749,3.678716585058067,,0.14968020708823,,3.68203676127121,4.460587391868653,6.16168876386834,0.6375600765589104,8.48252490386573,0.915306529272271,,,0.01730074058880675,,1.14151005025418,4.3014638922019595,,0.515257773430307,,0.10011497227209296,2.88088366427064,1.28860463750565,,2.2300027924209314,0.840906312130355,,,0.0333477836473014,0.0305592112201811,1.2293938651259,3.11743926451765,5.87117161618643,2.2425890948535088,0.113633221419215,,,,7.610550805928234,0.000801618515602082,,0.217321341594904,3.82083174402181,0.3700823645169542,4.1378080926721,1.59336683603281,0.27461658979806186,3.83716662310289,0.131017580370234,2.47508511994463,1.49152855539611,2.84019921473838,5.52291551246188,,,4.57621761053439,,2.01229337436415,3.9696358060138097,5.76564042583206,1.89225892053755,3.98716399952472,0.00537910069105995,1.2981314151304848,0.0329783341148504,5.410593709483698,0.132976375798844,,1.1329039678099684,,0.0953186557900055,9.40697847403536,1.3512718257062328,0.062139926308723545,0.000579757546590684,,,0.0004912741583087016,3.99230576710779,0.02816766122807735,1.52596160024961,2.67709778025311,0.247895548458292,,,,5.806430837251183,,,0.0123421528956834,,0.29566162608598545
-ACH-000890,2.7508060408911,3.2221381979395565,2.00930135324649,3.96394027146475,0.150921332007931,,,,3.95370844388332,,3.20670209941215,,0.0283539647572326,5.82893175814953,0.238106387514545,0.776629959191433,0.600518070688572,0.289437573705355,2.335996043860893,,3.20437197709175,,,0.133449885376458,3.33560866809336,,,7.28174841717471,2.37104493239462,,2.69689265299203,,,0.0277007349994116,5.01188264617896,1.27904634063523,6.131658359568972,,0.58083171237083,7.74425662665852,,2.4734250831204765,1.89162789053524,,9.11040565253736,0.4940115179304094,0.110493524575618,,0.379897218118452,0.006970751606446817,1.78284896003452,4.11789700016331,6.08848193933091,,,,,,8.04125234708076,0.000682258007599765,,0.481402750207642,,0.6994699560514193,6.72386018308835,2.69922606432728,0.0580047450400361,4.63745335071485,0.110270760726862,0.966891416877307,1.28654786351508,,2.82040573676944,0.26646953306847404,3.65405496874578,6.85232610820879,,3.9180563736047,,5.03666769305997,0.842601706278309,5.03236871706428,0.0054548653473781,1.0987502324776148,0.0870095563036655,6.818098981205921,0.465021137170415,,0.8056092227423395,,0.096519961061911,,,0.1527687483076609,0.0186323121900556,,5.531869265602709,0.0009407016806603415,3.88243891659964,0.8960051733804536,1.17109279401018,,0.141190985482841,,,,9.313058995782903,,,0.0266185886056092,,0.1212970319581455
-ACH-000900,1.38370819171265,2.806032368460401,0.654601085209798,,0.334056531687867,2.8140039404339,,,1.21915725974297,,0.695171588344693,7.2186844953894,0.041606922745481695,6.10584329855366,0.285001414708178,1.76039928840006,0.467379058250874,0.668263960377666,2.8306047563272694,,2.14476396295619,8.91535958993476,,0.127336144905307,,,3.4037707765176677,5.45256290812066,0.6531380235891776,,,,,0.0202433468880238,,1.03820557293328,3.9199618892111823,,0.133207836653311,,,1.8104881977271972,1.23374433227046,,2.57640598365348,0.0790494146610218,0.109431586330368,5.10379936066493,0.0621879975338757,0.0158518557648085,3.5715531034829,1.07530778757976,,,0.218726881034112,,,,,,,0.201418107648371,,0.568042746819368,0.745424793872625,1.13803092429742,0.0604055052041594,0.656985905010782,0.0301879815581202,1.38924808495248,0.931710164863571,5.93389161204912,2.33229200327998,0.07361093734760266,3.51021033293909,2.78584792151788,,1.01996286435864,1.408628333696436,,1.32786051556613,3.268885665757275,0.01711055473338325,2.618976660967477,0.0419142505954838,2.234120818971676,0.593142343017171,5.58403780246823,1.412733601046408,32.1357894906399,0.0777819784316028,2.39881058011283,1.63192650235521,0.11002521970300891,0.0412723215546649,,1.89387900500696,0.023478734909137152,,0.48082515426429756,,,0.0407126090024265,4.72604091027732,,,,,,0.0025697659826796,,0.06249507768995525
-ACH-000916,0.648712776688353,0.8192222325461536,1.77328541476846,3.22031055755777,0.0504783510839098,2.71156664632029,,2.41467387246613,1.21206625873054,,0.231771440061462,2.12363801967147,0.026110662669113202,6.66696259951913,0.734978271312827,0.662661380385198,0.51990412859736,0.165108995985399,1.8435113623787314,,1.76240535923394,3.27844943525938,,0.167365266303002,7.70747190428984,,1.83777819513211,3.8750514416892,0.7600666191842385,,,,,0.01512775068677115,1.96430203206697,0.65810557720323,4.769167791995502,,0.356973492579981,,0.581122507442568,2.527965964248658,0.799312404944568,,,5.474844470157619,0.0889139289593584,,0.02696472984005535,0.0072919836057901005,,2.35915410621802,,2.57085306931365,0.07103609407718531,,,,4.1675034968825235,0.0041705483277959,,0.328424435124562,,0.1080407140537532,,,0.358653496916321,6.07043914771547,0.0180816063093845,,1.40229323235969,,3.57143530149594,0.130926070862047,6.15005713334224,18.228994827259033,,3.886293153580457,3.89816185398602,,3.48910202642567,,0.0042416165220879,4.463550024488913,0.0161435064457121,6.82182317041303,0.591596692640132,9.409938169713e-05,1.7385042663825951,,0.635763846356751,4.96511940403111,,0.17470626362343594,0.0341960977403955,,3.528307249289151,0.050657162421679,5.35260977021942,0.34278993605287233,0.25087380787602,,1.04634704848832,,,,,,,0.0078757857909424,,0.046742146323452596
-ACH-000927,,2.2681139921462794,2.0011832988346,1.54071049486999,0.244574411674849,5.75560363560281,,0.396234519061618,2.57183409204926,,3.86883823058415,1.76921653169987,0.041467214475967046,,0.902190228538233,0.740205019330116,,3.45603183457556,9.993952990277098,30.1467816808395,0.0556613656552938,3.1588831804606414,,0.560826724151296,,,,,1.6530415153262306,,,2.52423776560769,,0.04019316094918895,,,,,,,,,2.30920460669557,,9.0348859361774,,,,1.54044066223377,0.125784943970589,,2.32674524566577,,0.484847946430374,,,,,0.9823818126885351,0.746148622636962,,1.25576278921448,,0.7221487660543429,,,,0.570877503309668,0.500515334589006,,,,5.64095833694842,,4.32544885499831,9.46354207244591,,0.5804169190614394,,,0.000201554249783454,4.02176762247944,0.0331352430941517,,0.06884959034814955,,1.807867727686,,3.4739133255529455,,,,,0.630910577230685,0.165709078003927,,4.306220811242319,9.25332736552906e-07,,3.78109451677025,1.55776648348415,,,0.7417996327558085,,,,,8.36966890834872,0.116695623076943,,0.208483383922367
-ACH-000932,,0.5697162418722739,,,,,,,,,,,0.0142644768241029,,,,,,5.367609484277426,,,8.008132457897691,,,,,,,1.382746217691058,,,,,0.0134173918352311,,,5.655657809433571,,,,0.1771864367339777,,,,,0.1883333985457411,,,0.0089247826587056,0.001985231031436,,,,,,,,,,,,,,0.0388763680351454,,,0.0134772909856495,,,,,,,0.003330393538924,,,,9.284519182874003,4.344586869889667,,,,0.0015409020201657,4.5010801743886715,0.0368135306500594,0.7898389306539102,,,1.1854452073154222,,,,0.3402272845986082,,,,4.022225795401005,0.0021348600221872,,0.080957930877493,,,,,,,9.366514387566031,,,,,0.2206307567261353
-ACH-000940,2.1325862873353,,2.07317627504742,0.986141917779017,,1.44790629728634,,0.615445028093242,2.11247642453428,0.801568738992256,2.47684316976601,0.700140816967727,0.003277384462133,2.31902278381981,0.0232211743430808,,0.142261087742746,0.0524670383563823,2.16596906440006,,,,,,3.09313212170301,,1.95826402740749,5.63996527890517,0.9973947544202406,,,,,0.0158582830816824,,1.00341733662901,6.666149456983345,,0.424634416772438,,0.4357926813547134,2.05766948274153,1.7891314261344,,2.7110363893352085,0.3786891542996025,0.121275690604502,2.544958141812,0.0134892825978197,0.005969554582019765,,,0.0490465625550869,0.742979410309702,0.0156301785603895,2.70277602562095,,2.08506351098441,7.28979842566185,,,0.131287040446523,,0.14570692273039,6.91551653610699,2.31483516970372,0.21515370625876895,0.254117206665544,0.992226085938632,0.52781499974507,1.47611688433775,5.20402083942474,1.97922254136927,0.2797402210866427,4.26277634757172,2.639416466897372,,3.0964318852011337,3.844734267560296,1.03105075386043,0.345312744756708,5.89042409937885,0.00439962054283125,4.247783262076436,0.03200759855126305,3.520874273810823,,,0.10569351961808585,,0.174559620562442,2.10581707360042,,0.12694129502507012,,,3.500298284256294,0.00018275249652280584,,0.098325839270824,1.62727016843559,,,,,,0.6440306595062577,,3.72758603352402,0.000686690489987436,,
-ACH-000943,2.19594894771609,0.2271302841856338,1.4692596229156,5.18901551381257,0.234662415616853,,,,3.79848600705278,,0.0366402396912409,,0.1281293334543731,1.88069767871803,1.97104682121774,2.21967002851009,0.661153237085529,0.183130280673295,2.37581519090981,,,,,,,,5.917437287353478,6.60228113015253,1.2594007268182985,,,,,0.01919841736548205,,1.63943845467973,7.77279660111493,0.000118423389272352,0.384974988904151,,0.6125472029735846,4.923506161769801,3.17948564854294,,9.764262955874706,1.4584275792195454,0.129041733917927,,0.21226400374368432,0.0336137056439502,3.57741566811012,5.00814186702709,,,,,,3.50984483673411,4.2906976252788,0.00053017707983415,,0.236069751411152,,0.2505895283598841,,,0.42394719095676475,0.344123071832996,0.0253904341672316,,0.742042753841095,,5.5868926150895,0.08252842367569965,,2.61799212452665,,3.03861783997269,,,0.660513751639871,6.81429206673643,0.006273767918282,2.902140662543169,0.12301014735901705,2.990376365921877,0.500165935124423,,2.2522857757649946,,0.0200292254887084,8.65076978054769,,0.2374465118997201,0.478729928404924,,,0.0383195644132161,,0.616186449026626,,,0.414984608186946,9.872477955817311,,,,,,0.000830279399972811,,0.0375153434712083
-ACH-000950,,2.311818385509464,6.94784838869121,1.13703033931569,0.0742301067708214,,,0.8732761114714855,1.45181650797708,1.04440029625423,2.92862937997326,0.190217272241348,0.0091681450752793,2.80736243208935,0.262825723959431,0.371346435160012,0.0500658832262797,0.479744947441835,1.0981853104974983,,0.520071989025732,,,0.512771076297633,,,2.20664673904254,,1.3591967192155368,,,,,0.0160648925482714,0.71234103919704,1.54196209279662,6.555030109552375,,0.223382826009147,,0.13576089970714833,0.51843127698911,1.40107324948567,,1.70761899696456,,,,0.350339162068272,0.038143238188563904,,,2.94473814605841,3.220753025406844,,,,,3.1238860143660103,3.45291902219308e-05,,0.157139767129519,,0.38370429482966417,,,0.1516307134850568,,0.383633710651772,,,,,,3.45355784493635,,,0.800861567597408,9.810029666247152,,0.835746508434987,6.34323251398568,0.0196421841642019,0.573728397209792,0.128034526417841,,0.873862235350955,6.59812177613263,1.1298006584064046,,0.0935933146387523,,,0.3250950134805683,0.516176214988085,,2.915020833747244,0.156223676912364,6.15133054743493,0.1057921448455891,,,0.170519558909563,,,,5.736831956128524,,,0.0149362642219637,,0.037252763153661654
-ACH-000954,0.740683754456556,1.2598061038387698,1.19698569593722,2.86245036016889,0.123651067931747,1.34163335123139,,,3.28868540805145,,0.399348374715695,2.88120308375686,0.0294402086110644,3.09732662152525,0.649063200668293,1.02170602625909,0.594469898923594,0.406532381278055,1.7488185169014678,,1.25686990887899,2.254987258958545,,0.510785553405728,,7.95691366700131,5.451165779776972,,0.6977310174126432,,,,,0.018755075013122652,2.10144576298142,1.49098265669882,5.177650220491065,,0.249050976589302,3.92563418727586,1.480362629675986,1.89429141425891,1.60877460443668,,,0.695387822039375,0.150034275251941,,0.0328580807792313,0.009450397885094,3.10706931609297,4.12215927498649,,,0.0057336970805601,,6.556964773694,,6.7491409675835,0.000511881460575635,,0.184166961458396,,0.2915989691318791,,,0.508218715340766,0.468387296341923,0.0841721778983927,0.928336342449516,1.29998085767275,5.14161385090364,19.7695094642955,0.2284933652099704,2.30829363406741,6.79277318381269,,5.46770596478848,,6.45478592599583,,4.720428744752425,0.004937469934586099,3.226606248904575,0.026697185034931396,7.658545176229043,0.64314829263676,,0.627211305875563,,0.0301181612928226,5.46346605717571,1.85247576352959,0.176622719417797,0.0817492696825632,3.33425649351707,4.694668678701968,0.0251522412592679,5.00862138989879,1.27562590446075,1.07047619246302,,0.297317817891458,,,,7.207142839004339,,7.05674474069691,0.0032070331691031,,0.06243676678446635
-ACH-000957,1.10632127745778,1.4486495845791412,1.41047359308063,,0.214925058073068,2.33541238034157,,2.440785176353338,,,0.5459124361392,0.0811538212450774,0.0678466997898729,5.27754004548763,0.778027497656938,1.39567749931365,,0.361664401941392,2.3910630974922955,,0.0531199192016637,4.50162267416762,,0.126943392789253,4.13392297398728,,7.411950969843618,,1.7608185333485857,7.72268660353903,,,,0.024698137780868552,1.75677407976515,1.60012122425754,4.75083354910034,,0.51217632243398,,0.1343810413251524,2.4796644925925184,5.65385514290211,,,2.562788176299388,0.23135296504261,,0.0392785950856021,0.02177635209338695,5.7248013909335,2.43805364050918,,,,,,,5.249769682078663,,,0.237945994038211,,0.0997099775929578,,2.80423573024746,0.0969070367834799,7.4291429438116,0.416893353204647,,1.46924633322975,,2.70136524043782,0.25600704110607914,3.34936644803774,5.8946074220389,,0.610523950314952,,1.46635971397137,0.362171765365368,,0.00952390880833015,1.97215777698904,0.0508298929537359,2.1957497862912665,1.56789782182353,1.6695397185901098e+43,2.054871683218742,0.724725617991879,0.0320230164812522,,9.62129808057135,0.26871623732888217,0.186209766870621,9.43217410052109,3.0020654584987225,21.0365630282281,5.23505113027003,0.0471552405374267,1.31016211181432,,0.118078050172234,,,,4.927843830185069,,,0.143523390121798,7.11442926921064,0.3327573239601252
-ACH-000958,,1.0544329001324442,0.28585911226709,0.757714017093275,0.142148593366709,1.23887360940324,,,6.1614497281546,,2.46134512336068,0.882531060693129,0.0875869460423442,,,1.27992751657834,,0.0286105606647994,5.248110183217237,,0.619103693190185,,,0.20626674197921,,,,0.717920453089732,1.5713561414720985,,,,,0.014842850024576651,1.33178814636329,2.18080672709883,4.5547166451692,,0.155116873035734,,0.115474452446181,0.877057757110407,2.07184230658106,,,,,,0.33938603329996,0.00791848855254035,,0.835497738625489,,0.143563899836001,0.000422130317547165,,,,1.15974515151385,,,0.180364326006865,,0.0849275404539349,,,0.400374480398333,,0.0984865370441754,1.23365005360738,,,2.67041615046714,,,,,,,,3.6961447535308,,0.0103379378373555,,0.10169458580964194,,0.722959956649924,,2.101285047023895,,0.0554640219277222,,2.51574943141052,0.109612327359444,0.823198762398031,,,0.255153745462608,,0.592731500370735,0.655555251814385,,159078826040706.0,,,,4.87248932600936,,,,,0.076282453346538
-ACH-000997,2.0057272066279,6.618374622780075,2.12660694725441,,0.0876190190266411,2.94983568191352,,,2.33688158104895,,3.47540358233991,4.79751923050418,0.0436358502966694,6.07004519962432,0.487452939587524,0.576768611799226,,0.743380712527379,1.948947911792462,,1.17711680172593,2.12397903975444,,0.201423299794973,2.41608374482904,4.41592956377153,2.63953779054371,3.61359664530799,2.19228354684769,,1.2378757043508,,,0.034686157754758,,1.57707236963523,2.7071776404718424,,0.231348393566658,,3.25133856167015,2.8102249554268557,1.60794279502494,,,0.241155939539196,0.205698248214977,7.79384913934585,0.24531867471694296,0.1374930074578282,2.6477580372549,3.00078737061505,,1.60431409888173,0.7695762014936072,,,,7.056256659538638,9.82949027829766e-05,,0.57644564538172,6.95097457270314,0.40076065816440165,4.65207284946115,1.52217698430927,0.59076236186395,0.96783029955574,0.0685311423517203,0.916641851206042,0.915868837180163,,5.39394376007802,0.2717413673021758,3.21407155423499,2.68721496816792,,1.59245119759128,,,3.6193331540438,3.81469720026562,0.1078802741875167,4.727726206047662,0.211860593359669,3.2361126086591137,0.743012351658684,,1.6576917206965467,,0.103428455893353,4.05307378298957,,0.32528133610438703,0.0017795015259759,,3.5303648541353327,0.0542079136509819,6.63124842967025,1.86861114517364,7.02884686581777,,0.223364522977808,,2.99724436917308,,9.349055189497758,1.426977350006,,0.343646517777822,,0.22936551711617487
-ACH-001190,,3.149146970701027,1.31339796271594,6.55950451298889,0.454167591938334,5.70342466398214,,,8.48860707522369,0.393495934347373,0.168157679166606,0.721422578821297,0.1173890329392295,6.2719264877625,0.427220229789527,1.7315386686419,0.10850852486775,0.550322606132422,4.413704276462094,,2.74933977963333,3.37289072854325,,0.113484268026635,7.17421926591136,,4.082775052309703,4.77525624405892,1.96074224039168,,,,,0.0111951052686322,0.156348389696606,1.09673228534239,3.3168965159394315,,0.186086161056099,,0.1534771891796894,2.66160942667004,2.9126418537359,,4.38412151939935,0.41776767994341074,,,0.1151739203926357,0.0141164133596094,5.07382202353909,2.4448384494125,,,,,,,2.74933512692748,0.000499241922546411,,0.628641412691738,,0.531808099268597,,,,,0.158667404535077,,1.07256390815725,,4.55568987055293,0.0078908837785465,5.20126184931048,4.616482052226261,4.61133831463408e-07,5.157638890344152,9.917388081670213,2.88144672479148,,6.40963938430844,0.0038406473124671,3.099226024567968,0.0448771235881556,2.2977510038291653,1.13846581035298,0.0127264532210063,0.9724612287411853,,0.0642652471750521,,,0.09556987824743775,1.36809334997038,,7.2335511767253635,,5.46132655085541,0.107229541888037,1.10785816268889,,0.600529536684675,,,,,,,0.0015528362221169,,0.07801597989880721

data/Tahoe_PRISM_matched_cell_metadata_final.csv

@@ -1,48 +0,0 @@
-depmap_id,cell_name,Cell_ID_DepMap,Cell_ID_Cellosaur,Organ,Driver_Gene_Symbol,Driver_VarZyg,Driver_VarType,Driver_ProtEffect_or_CdnaEffect,Driver_Mech_InferDM,Driver_GeneType_DM,ccle_name,primary_tissue,secondary_tissue,tertiary_tissue,passed_str_profiling,row_name
-ACH-000120,CHP-212,ACH-000120,CVCL_1125,Peripheral Nervous System,NRAS,Het,Missense,p.Q61K,GoF,Oncogene,CHP212_AUTONOMIC_GANGLIA,peripheral_nervous_system,neuroblastoma,,True,PR500_ACH-000120
-ACH-000120,CHP-212,ACH-000120,CVCL_1125,Peripheral Nervous System,NRAS,Het,Missense,p.Q61K,GoF,Oncogene,CHP212_AUTONOMIC_GANGLIA,peripheral_nervous_system,neuroblastoma,,True,PR300_ACH-000120
-ACH-000138,CFPAC-1,ACH-000138,CVCL_1119,Pancreas,KRAS,Het,Missense,p.G12V,GoF,Oncogene,CFPAC1_PANCREAS,pancreas,,,True,PR500_ACH-000138
-ACH-000139,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,ATM,Het,Missense,p.E2351G,LoF,Suppressor,PANC0327_PANCREAS,pancreas,,,True,PR500_ACH-000139
-ACH-000164,PANC-1,ACH-000164,CVCL_0480,Pancreas,AKT2,,Gain,GAIN,GoF,Oncogene,PANC1_PANCREAS,pancreas,,,True,PR500_ACH-000164
-ACH-000178,Hs 766T,ACH-000178,CVCL_0334,Pancreas,ARID1A,Het,Stopgain,p.Q538*,LoF,Suppressor,HS766T_PANCREAS,pancreas,,,True,PR500_ACH-000178
-ACH-000222,AsPC-1,ACH-000222,CVCL_0152,Pancreas,CDKN2A,Het,Frameshift,p.L27fs,LoF,Suppressor,ASPC1_PANCREAS,pancreas,,,True,PR500_ACH-000222
-ACH-000311,NCI-H2122,ACH-000311,CVCL_1531,Lung,CDKN2A,,Deletion,DEL,LoF,Suppressor,NCIH2122_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000311
-ACH-000348,RPMI-7951,ACH-000348,CVCL_1666,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene,RPMI7951_SKIN,skin,melanoma,,True,PR500_ACH-000348
-ACH-000348,RPMI-7951,ACH-000348,CVCL_1666,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene,RPMI7951_SKIN,skin,melanoma,,True,PR300_ACH-000348
-ACH-000389,H4,ACH-000389,CVCL_1239,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,H4_CENTRAL_NERVOUS_SYSTEM,central_nervous_system,glioma,,True,PR500_ACH-000389
-ACH-000396,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,APC,Het,Missense,p.S770P,,Suppressor,J82_URINARY_TRACT,urinary_tract,,,True,PR500_ACH-000396
-ACH-000437,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,SW1088_CENTRAL_NERVOUS_SYSTEM,central_nervous_system,glioma,,True,PR500_ACH-000437
-ACH-000463,NCI-H460,ACH-000463,CVCL_0459,Lung,ARID1A,Hom,Missense,p.LI1917del,,Suppressor,NCIH460_LUNG,lung,lung_NSC,lung_large,True,PR500_ACH-000463
-ACH-000493,SNU-423,ACH-000493,CVCL_0366,Liver,ARID1A,Hom,Stopgain,p.G623*,LoF,Suppressor,SNU423_LIVER,liver,,,True,PR500_ACH-000493
-ACH-000496,NCI-H1792,ACH-000496,CVCL_1495,Lung,CDKN2A,Het,Stopgain,p.W110*,LoF,Suppressor,NCIH1792_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000496
-ACH-000521,NCI-H2030,ACH-000521,CVCL_1517,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene,NCIH2030_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000521
-ACH-000552,HT-29,ACH-000552,CVCL_0320,Bowel,APC,Het,Stopgain,p.E853*,LoF,Suppressor,HT29_LARGE_INTESTINE,colorectal,,,True,PR500_ACH-000552
-ACH-000555,A498,ACH-000555,CVCL_1056,Kidney,APC,Het,Missense,p.C1270R,LoF,Suppressor,A498_KIDNEY,kidney,,,True,PR500_ACH-000555
-ACH-000555,A498,ACH-000555,CVCL_1056,Kidney,APC,Het,Missense,p.C1270R,LoF,Suppressor,A498_KIDNEY,kidney,,,True,PR300_ACH-000555
-ACH-000558,A-172,ACH-000558,CVCL_0131,CNS/Brain,ABL1,,Fusion,ABL1-CBFB,,Oncogene,A172_CENTRAL_NERVOUS_SYSTEM,central_nervous_system,glioma,glioblastoma,True,PR500_ACH-000558
-ACH-000580,C32,ACH-000580,CVCL_1097,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene,C32_SKIN,skin,melanoma,,True,PR500_ACH-000580
-ACH-000580,C32,ACH-000580,CVCL_1097,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene,C32_SKIN,skin,melanoma,,True,PR300_ACH-000580
-ACH-000601,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,ARID1A,Het,Missense,p.P1723L,,Suppressor,MIAPACA2_PANCREAS,pancreas,,,True,PR500_ACH-000601
-ACH-000628,NCI-H596,ACH-000628,CVCL_1571,Lung,KMT2D,Het,Missense,p.M4058V,,Suppressor,NCIH596_LUNG,lung,lung_NSC,,True,PR500_ACH-000628
-ACH-000669,SW 900,ACH-000669,CVCL_1731,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,SW900_LUNG,lung,lung_NSC,lung_squamous,True,PR500_ACH-000669
-ACH-000681,A549,ACH-000681,CVCL_0023,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,A549_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000681
-ACH-000750,LOX-IMVI,ACH-000750,CVCL_1381,Skin,ARID1A,Het,Stopgain,p.Q1212*,LoF,Suppressor,LOXIMVI_SKIN,skin,melanoma,,True,PR500_ACH-000750
-ACH-000757,A-427,ACH-000757,CVCL_1055,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,A427_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR300_ACH-000757
-ACH-000790,SHP-77,ACH-000790,CVCL_1693,Lung,ABL1,Het,Missense,p.V1128E,,Oncogene,SHP77_LUNG,lung,lung_small,,True,PR300_ACH-000790
-ACH-000793,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,ATM,Het,Missense,p.S2581I,,Suppressor,KATOIII_STOMACH,gastric,gastric_adenocarcinoma,,True,PR300_ACH-000793
-ACH-000842,SW480,ACH-000842,CVCL_0546,Bowel,APC,Hom,Stopgain,p.Q1338*,LoF,Suppressor,SW480_LARGE_INTESTINE,colorectal,,,True,PR500_ACH-000842
-ACH-000853,NCI-H661,ACH-000853,CVCL_1577,Lung,BRCA2,Het,Missense,p.G2584V,LoF,Suppressor,NCIH661_LUNG,lung,lung_NSC,lung_large,True,PR500_ACH-000853
-ACH-000875,NCI-H2347,ACH-000875,CVCL_1550,Lung,B2M,Hom,Stopgain,p.Q28*,LoF,Suppressor,NCIH2347_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000875
-ACH-000890,SW 1271,ACH-000890,CVCL_1716,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor,SW1271_LUNG,lung,lung_small,,True,PR500_ACH-000890
-ACH-000900,NCI-H23,ACH-000900,CVCL_1547,Lung,ATM,Hom,Missense,p.Q1919P,LoF,Suppressor,NCIH23_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000900
-ACH-000916,NCI-H1573,ACH-000916,CVCL_1478,Lung,CDKN2A,Het,Missense,p.D23P,,Suppressor,NCIH1573_LUNG,lung,lung_NSC,lung_adenocarcinoma,True,PR500_ACH-000916
-ACH-000927,BT-474,ACH-000927,CVCL_0179,Breast,ACVR2A,Het,Missense,p.S17F,,Suppressor,BT474_BREAST,breast,TPBC,,True,PR500_ACH-000927
-ACH-000932,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor,SNU1_STOMACH,gastric,,,True,PR300_ACH-000932
-ACH-000940,AN3 CA,ACH-000940,CVCL_0028,Uterus,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor,AN3CA_ENDOMETRIUM,uterus,uterus_endometrium,,True,PR500_ACH-000940
-ACH-000943,RKO,ACH-000943,CVCL_0504,Bowel,ACVR2A,Het,Frameshift,p.K437fs,LoF,Suppressor,RKO_LARGE_INTESTINE,colorectal,colorectal_MSI,,True,PR500_ACH-000943
-ACH-000950,LoVo,ACH-000950,CVCL_0399,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor,LOVO_LARGE_INTESTINE,colorectal,colorectal_MSI,,True,PR500_ACH-000950
-ACH-000954,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ACVR2A,Het,Missense,p.A349T,,Suppressor,HEC1A_ENDOMETRIUM,uterus,uterus_endometrium,,True,PR500_ACH-000954
-ACH-000957,LS 180,ACH-000957,CVCL_0397,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor,LS180_LARGE_INTESTINE,colorectal,colorectal_MSI,,True,PR500_ACH-000957
-ACH-000958,SW48,ACH-000958,CVCL_1724,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor,SW48_LARGE_INTESTINE,colorectal,colorectal_MSI,,True,PR500_ACH-000958
-ACH-000997,HCT15,ACH-000997,CVCL_0292,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor,HCT15_LARGE_INTESTINE,colorectal,colorectal_MSI,,True,PR500_ACH-000997
-ACH-001190,SK-MEL-2,ACH-001190,CVCL_0069,Skin,CCND1,,Gain,GAIN,GoF,Oncogene,SKMEL2_SKIN,skin,melanoma,,True,PR500_ACH-001190

data/Tahoe_PRISM_matched_drug_metadata_final.csv

@@ -1,94 +0,0 @@
-drug_x,drug_y,targets,moa-broad,moa-fine,human-approved,clinical-trials,gpt-notes-approval,canonical_smiles,pubchem_cid
-5-fluorouracil,5-Fluorouracil,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used chemotherapy drug. Approved for cancer treatment.,C1=C(C(=O)NC(=O)N1)F,3385.0
-AZD2858,AZD2858,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,no,Investigated in rodent models.,CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N,10138980.0
-BI-78D3,BI-78D3,,inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigated for Alzheimer's and inflammatory diseases, not approved for human use.",C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-],2747117.0
-LY2090314,LY2090314,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,yes,Investigated for Alzheimer's; not approved for any condition.,C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7,10029385.0
-NVP-BHG712,NVP-BHG712,EPHB4,inhibitor/antagonist,unclear,no,yes,Investigated as angiogenesis inhibitor; not approved for human use.,CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=C4C=NN(C4=NC(=N3)C5=CN=CC=C5)C,16747388.0
-TAK-733,TAK-733,MAP2K1,inhibitor/antagonist,MEK inhibitor,no,yes,Investigated as anti-cancer MEK inhibitor; not approved for human use.,CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O,24963252.0
-TAK-901,TAK-901,AURKB,inhibitor/antagonist,unclear,no,yes,Investigational cancer drug; not approved for human use yet.,CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C,16124208.0
-abemaciclib,Abemaciclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,"FDA approved for HR-positive, HER2-negative breast cancer.",CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F,46220502.0
-acetazolamide,Acetazolamide,,inhibitor/antagonist,unclear,yes,yes,"Used to treat glaucoma, epilepsy, and altitude sickness since 1950s.",CC(=O)NC1=NN=C(S1)S(=O)(=O)N,1986.0
-afatinib,Afatinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,"Approved for treatment of certain cancers, such as non-small cell lung cancer.",CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4,10184653.0
-alpelisib,Alpelisib,PIK3CA,inhibitor/antagonist,PI3K/AKT inhibitor,yes,yes,Approved for HR+/HER2- advanced breast cancer in combination with fulvestrant.,CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F,56649450.0
-altretamine,Altretamine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as a chemotherapy drug for ovarian cancer.,CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C,2123.0
-amsacrine,Amsacrine,TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in the treatment of acute leukemias.,COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42,2179.0
-artesunate,Artesunate,,inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,"Used for severe malaria, often partnered with other antimalarial drugs.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C,6917864.0
-aspirin,Aspirin,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used widely for pain relief and anti-inflammatory purposes.,CC(=O)OC1=CC=CC=C1C(=O)O,2244.0
-baicalin,Baicalin,,activator/agonist,unclear,no,yes,"Used in traditional medicine, researched for various pharmacological effects.",C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O,64982.0
-belinostat,Belinostat,HDAC6,inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for relapsed/refractory peripheral T-cell lymphoma.,C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO,6918638.0
-bendamustine,Bendamustine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in leukemia and lymphoma treatment.,CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O,65628.0
-bexarotene,Bexarotene,"RXRA, RXRB, RXRG",activator/agonist,Retinoic receptor agonist,yes,yes,Approved for treating cutaneous T-cell lymphoma.,CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C,82146.0
-bicalutamide,Bicalutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Approved as antiandrogen for prostate cancer treatment.,CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O,2375.0
-bortezomib,Bortezomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma and mantle cell lymphoma.,B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O,387447.0
-busulfan,Busulfan,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in bone marrow transplantation.,CS(=O)(=O)OCCCCOS(=O)(=O)C,2478.0
-ciclopirox,Ciclopirox,,unclear,unclear,yes,yes,"Approved for antifungal use, primarily in nail and skin treatments.",CC1=CC(=O)N(C(=C1)C2CCCCC2)O,2749.0
-cinacalcet,Cinacalcet,CASR,activator/agonist,unclear,yes,yes,Used to treat secondary hyperparathyroidism and parathyroid carcinoma.,CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F,156419.0
-clofarabine,Clofarabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for leukemia treatment in pediatric patients.,C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N,119182.0
-clotrimazole,Clotrimazole,"CYP2A6, CYP51A1",inhibitor/antagonist,unclear,yes,yes,Antifungal used in topical and oral preparations.,C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4,2812.0
-cobimetinib,Cobimetinib,MAP2K1,inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma in combination with vemurafenib.,C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O,16222096.0
-crizotinib,crizotinib,"ALK, MET, ROS1",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for NSCLC treatment.,CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N,11626560.0
-dabrafenib,Dabrafenib,"BRAF, RAF1",inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for melanoma treatment.,CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F,44462760.0
-decitabine,Decitabine,"DNMT1, DNMT3A, DNMT3B",inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,Approved for treatment of myelodysplastic syndromes and acute myeloid leukemia.,C1C(C(OC1N2C=NC(=NC2=O)N)CO)O,451668.0
-digitoxin,Digitoxin,,unclear,unclear,no,yes,"Clinical trials for certain conditions, but not FDA approved for human use.",CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O,441207.0
-dihydroartemisinin,Dihydroartemisinin,,unclear,unclear,yes,yes,"Active metabolite of artemisinin, approved for malaria treatment.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C,3000518.0
-dinaciclib,Dinaciclib,"CDK1, CDK2, CDK5, CDK9",inhibitor/antagonist,CDK inhibitor,no,yes,Investigated in trials; not yet approved for human use.,CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO,46926350.0
-docetaxel,Docetaxel,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,"Approved anticancer drug, often used in chemotherapy treatments.",CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O,148124.0
-drospirenone,Drospirenone,,unclear,unclear,yes,yes,"Found in birth control, often combined with ethinyl estradiol.",CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C,68873.0
-eplerenone,Eplerenone,NR3C2,inhibitor/antagonist,unclear,yes,yes,Used to treat heart failure and hypertension.,CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC,443872.0
-erdafitinib,Erdafitinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for bladder cancer treatment.,CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC,67462786.0
-erlotinib,Erlotinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use for non-small cell lung cancer.,COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC,176870.0
-everolimus,Everolimus,"MTOR, FKBP1A",inhibitor/antagonist,MTOR inhibitor,yes,yes,"Approved for certain types of cancer, organ transplantation, and tuberous sclerosis.",CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC,6442177.0
-filgotinib,Filgotinib,"JAK1, JAK2, TYK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved in Japan and EU for rheumatoid arthritis.,C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5,49831257.0
-flutamide,Flutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Used to treat prostate cancer as an antiandrogen.,CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F,3397.0
-fulvestrant,Fulvestrant,ESR1,inhibitor/antagonist,unclear,yes,yes,Estrogen receptor antagonist used for hormone receptor-positive breast cancer.,CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F,104741.0
-gefitinib,Gefitinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for non-small cell lung cancer.,COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4,123631.0
-gemcitabine,Gemcitabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment like pancreatic and non-small cell lung cancer.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F,60750.0
-glasdegib,Glasdegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Glasdegib is approved for acute myeloid leukemia.,CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N,25166913.0
-harringtonine,Harringtonine,,unclear,Protein synthesis inhibitor,no,yes,"Investigated in trials mainly for cancer treatment, often used as basis for derivatives.",CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,276389.0
-hexylresorcinol,Hexylresorcinol,,inhibitor/antagonist,unclear,yes,yes,Used in throat lozenges and skin creams for antiseptic purposes.,CCCCCCC1=C(C=C(C=C1)O)O,3610.0
-homoharringtonine,Homoharringtonine,,inhibitor/antagonist,Protein synthesis inhibitor,yes,yes,"Used in leukemia treatment, also known as Omacetaxine.",CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,285033.0
-hydroxyurea,Hydroxyurea,"RRM2, RRM1",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for sickle cell anemia and certain cancers.,C(=O)(N)NO,3657.0
-idoxuridine,Idoxuridine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as topical antiviral in eye infections. Approved for human use.,C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O,5905.0
-irinotecan,Irinotecan,TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,"Used in cancer treatment, especially for colorectal cancer.",CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7,60838.0
-ivermectin,Ivermectin,,unclear,unclear,yes,yes,Approved for infections in humans and animals.,CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C,6321424.0
-ixazomib,Ixazomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma treatment.,B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O,25183872.0
-lonafarnib,Lonafarnib,"HRAS, KRAS, NRAS",inhibitor/antagonist,RAS inhibitor,yes,yes,Approved for progeria treatment in children.,C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N,148195.0
-mebendazole,Mebendazole,"TUBA1A, TUBA1B, TUBA1C, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB4B, TUBB6",inhibitor/antagonist,Microtubule inhibitor,yes,yes,Approved for treating parasitic worm infestations.,COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3,4030.0
-meloxicam,Meloxicam,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Meloxicam is an approved NSAID for pain and inflammation.,CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O,54677470.0
-menadione,Menadione,,unclear,unclear,no,yes,"Used in trials; a vitamin K analog, not fully approved for human use.",CC1=CC(=O)C2=CC=CC=C2C1=O,4055.0
-methotrexate,Methotrexate,DHFR,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used for cancer and autoimmune diseases treatments.,CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O,126941.0
-mifepristone,Mifepristone,"NR3C1, PGR",inhibitor/antagonist,unclear,yes,yes,Approved for medical abortion and Cushing's syndrome treatment.,CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O,55245.0
-mozavaptan,Mozavaptan,AVPR2,inhibitor/antagonist,unclear,no,yes,In trials for conditions like hyponatremia but not approved for use.,CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C,119369.0
-naproxen,Naproxen,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used as non-prescription NSAID in many countries.,CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O,156391.0
-neratinib,Neratinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for breast cancer treatment.,CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C,9915743.0
-olaparib,olaparib,"PARP1, PARP2",unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for BRCA-mutated cancers.,C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F,23725625.0
-omeprazole,Omeprazole,,inhibitor/antagonist,unclear,yes,yes,Used as part of racemic mixture for acid-related conditions.,CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC,4594.0
-oxaliplatin,Oxaliplatin,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for use in chemotherapy treatments.,C1CCC(C(C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2],9887053.0
-paclitaxel,Paclitaxel,,unclear,Microtubule inhibitor,yes,yes,Chemotherapy drug approved for cancer treatment.,CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C,36314.0
-palbociclib,palbociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use as a cancer treatment.,CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C,5330286.0
-panobinostat,Panobinostat,"HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, HDAC11",inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for multiple myeloma treatment.,CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO,6918837.0
-pemetrexed,Pemetrexed,"TYMS, DHFR, GART",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Chemotherapy drug for mesothelioma and non-small cell lung cancer.,C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O,135410875.0
-penfluridol,Penfluridol,DRD2,inhibitor/antagonist,unclear,yes,yes,Long-acting antipsychotic drug approved for human use.,C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F,33630.0
-pentagastrin,Pentagastrin,CCKBR,inhibitor/antagonist,unclear,yes,yes,Used mainly in diagnostic tests for gastric functions.,CC(C)(C)OC(=O)NCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N,9853654.0
-ponatinib,Ponatinib,"ABL1, PDGFRA, KDR, FGFR1, SRC, KIT",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for treatment of certain types of leukemia.,CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5,24826799.0
-posaconazole,Posaconazole,,unclear,unclear,yes,yes,Broad-spectrum antifungal approved for human use.,CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F,468595.0
-raltitrexed,Raltitrexed,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment as thymidylate synthase inhibitor.,CC1=NC2=C(C=C(C=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1,135400182.0
-regorafenib,Regorafenib,"BRAF, FLT1, FLT4, KDR, KIT, PDGFRB, RAF1, RET, TEK",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,"Used for metastatic colorectal cancer, GIST, HCC.",CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F,11167602.0
-ribociclib,Ribociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use in combination with letrozole for breast cancer.,CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5,44631912.0
-selinexor,Selinexor,XPO1,inhibitor/antagonist,unclear,yes,yes,Approved for certain cancer treatments.,C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F,71481097.0
-sonidegib,Sonidegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for basal cell carcinoma treatment.,CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F,24775005.0
-sunitinib,Sunitinib,"KDR, PDGFRB",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved anticancer drug used for renal cell carcinoma and gastrointestinal stromal tumors.,CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C,5329102.0
-temsirolimus,Temsirolimus,MTOR,inhibitor/antagonist,MTOR inhibitor,yes,yes,Approved for treating renal cell carcinoma.,CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC,6918289.0
-terfenadine,Terfenadine,HRH1,inhibitor/antagonist,unclear,no,yes,Withdrawn due to cardiac toxicity; replaced by fexofenadine.,CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O,5405.0
-trametinib,Trametinib,"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma treatment.,CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5,11707110.0
-tranilast,Tranilast,"PLA2G2A, EGR1",inhibitor/antagonist,unclear,yes,yes,Approved for asthma and allergic disorders in some countries.,COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC,5282230.0
-triamcinolone,Triamcinolone,NR3C1,unclear,Glucocorticoid receptor agonist,yes,yes,Approved corticosteroid for various inflammatory and allergic conditions.,CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O,31307.0
-trifluridine,Trifluridine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used to treat viral infections and in cancer therapy (with tipiracil).,C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O,6256.0
-tucatinib,Tucatinib,ERBB2,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use in advanced HER2-positive breast cancer.,CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5,51039094.0
-uridine,Uridine,,unclear,unclear,no,yes,"Studied in trials; not approved as standalone drug, essential body metabolite.",C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O,6029.0
-vandetanib,Vandetanib,"EGFR, KDR",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for use in medullary thyroid cancer.,CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC,3081361.0
-vemurafenib,Vemurafenib,BRAF,inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for treating BRAF V600E mutation-positive melanoma.,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F,42611257.0
-venetoclax,venetoclax,BCL2,inhibitor/antagonist,unclear,yes,yes,Approved for chronic lymphocytic leukemia and other cancers.,CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C,49846579.0
-vincristine,vincristine,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,Used in chemotherapy for various cancers.,CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,249332.0
-vismodegib,Vismodegib,"SMO, ABCB1, ABCG2",inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for treating basal cell carcinoma.,CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl,24776445.0
-volasertib,Volasertib,"PLK1, PLK2, PLK3",inhibitor/antagonist,unclear,no,yes,"Investigated for cancer treatment, not approved for human use.",CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C,10461508.0

data/cell_line_metadata.csv

@@ -1,1001 +0,0 @@
-cell_name,Cell_ID_DepMap,Cell_ID_Cellosaur,Organ,Driver_Gene_Symbol,Driver_VarZyg,Driver_VarType,Driver_ProtEffect_or_CdnaEffect,Driver_Mech_InferDM,Driver_GeneType_DM
-A549,ACH-000681,CVCL_0023,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-A549,ACH-000681,CVCL_0023,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-A549,ACH-000681,CVCL_0023,Lung,KRAS,Hom,Missense,p.G12S,GoF,Oncogene
-A549,ACH-000681,CVCL_0023,Lung,SMARCA4,Hom,Frameshift,p.Q729fs,LoF,Suppressor
-A549,ACH-000681,CVCL_0023,Lung,STK11,Hom,Stopgain,p.Q37*,LoF,Suppressor
-A549,ACH-000681,CVCL_0023,Lung,ZFHX3,Het,Missense,p.L1473F,,Suppressor
-HOP-92,ACH-000825,CVCL_1286,Lung,ACVR2A,Het,Missense,p.K133M,LoF,Suppressor
-HOP-92,ACH-000825,CVCL_1286,Lung,GNAS,Het,Missense,p.V117M,,Oncogene
-HOP-92,ACH-000825,CVCL_1286,Lung,NF1,Het,Frameshift,p.M799fs,LoF,Suppressor
-HOP-92,ACH-000825,CVCL_1286,Lung,SOS1,Het,Missense,p.N233Y,GoF,Oncogene
-HOP-92,ACH-000825,CVCL_1286,Lung,TP53,Hom,Missense,p.R175L,LoF,Suppressor
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,B2M,Hom,Deletion,DEL,LoF,Suppressor
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,BRAF,Het,Missense,p.G469V,GoF,Oncogene
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,BRCA2,Het,Missense,p.M784V,,Suppressor
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,RB1,Het,Missense,p.L819V,,Suppressor
-HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,TP53,Het,Missense,p.N268I,LoF,Suppressor
-Hs 936.T(C1),,CVCL_1034,Skin,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-MM485,ACH-001973,CVCL_2610,Skin,APC,Het,Missense,p.P2783S,LoF,Suppressor
-MM485,ACH-001973,CVCL_2610,Skin,CDKN2A,Hom,Stopgain,p.W59*,LoF,Suppressor
-MM485,ACH-001973,CVCL_2610,Skin,NRAS,Het,Missense,p.Q61R,GoF,Oncogene
-MM485,ACH-001973,CVCL_2610,Skin,SMARCB1,Het,Missense,p.W349L,LoF,Suppressor
-MM485,ACH-001973,CVCL_2610,Skin,TP53,Hom,Stopgain,p.R196*,LoF,Suppressor
-MM415,ACH-001569,CVCL_2608,Skin,KMT2D,Het,Missense,p.T680P,,Suppressor
-MM415,ACH-001569,CVCL_2608,Skin,MTOR,Het,Missense,p.L2185F,,Oncogene
-MM415,ACH-001569,CVCL_2608,Skin,NF1,Het,Stopgain,p.R1276*,LoF,Suppressor
-MM415,ACH-001569,CVCL_2608,Skin,NRAS,Het,Missense,p.Q61L,GoF,Oncogene
-MM415,ACH-001569,CVCL_2608,Skin,SMARCB1,Het,Missense,p.T214M,LoF,Suppressor
-MM415,ACH-001569,CVCL_2608,Skin,TP53,Hom,Missense,p.A347V,,Suppressor
-MCF-7,ACH-000019,CVCL_0031,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-MCF-7,ACH-000019,CVCL_0031,Breast,GNAS,,Gain,GAIN,GoF,Oncogene
-MCF-7,ACH-000019,CVCL_0031,Breast,NRAS,,Gain,GAIN,GoF,Oncogene
-MCF-7,ACH-000019,CVCL_0031,Breast,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
-MCF-7,ACH-000019,CVCL_0031,Breast,SMAD3,Het,Splice_site,p.V90F,LoF,Suppressor
-MCF-7,ACH-000019,CVCL_0031,Breast,WNK2,Het,Missense,p.L312Q,,Suppressor
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,APC,Het,Missense,p.G1339R,,Suppressor
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,APC,Het,Stopgain,p.Q1406*,LoF,Suppressor
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,BRAF,Het,Missense,p.E275K,,Oncogene
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,CDKN2A,Hom,Missense,p.P63L,LoF,Suppressor
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,TP53,Het,Missense,p.R273H,LoF,Suppressor
-SK-MEL-30,ACH-000810,CVCL_0039,Skin,TP53,Het,Frameshift,p.T284fs,LoF,Suppressor
-SW620,ACH-000651,CVCL_0547,Bowel,APC,Hom,Stopgain,p.Q1338*,LoF,Suppressor
-SW620,ACH-000651,CVCL_0547,Bowel,EGFR,Het,Missense,p.C186S,,Oncogene
-SW620,ACH-000651,CVCL_0547,Bowel,EP300,Het,Missense,p.P1440L,LoF,Suppressor
-SW620,ACH-000651,CVCL_0547,Bowel,KRAS,,Gain,GAIN,GoF,Oncogene
-SW620,ACH-000651,CVCL_0547,Bowel,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
-SW620,ACH-000651,CVCL_0547,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
-SW620,ACH-000651,CVCL_0547,Bowel,TP53,Hom,Missense,p.P309S,LoF,Suppressor
-SW620,ACH-000651,CVCL_0547,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
-COLO 205,ACH-001039,CVCL_0218,Bowel,APC,Hom,Frameshift,p.T1556fs,LoF,Suppressor
-COLO 205,ACH-001039,CVCL_0218,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-COLO 205,ACH-001039,CVCL_0218,Bowel,CTNNB1,Hom,Missense,p.N287S,,Oncogene
-COLO 205,ACH-001039,CVCL_0218,Bowel,GNAS,Het,Missense,p.S95I,,Oncogene
-COLO 205,ACH-001039,CVCL_0218,Bowel,MTOR,Het,Missense,p.P1193L,,Oncogene
-COLO 205,ACH-001039,CVCL_0218,Bowel,PMS2,Het,Missense,p.E504Q,,Suppressor
-COLO 205,ACH-001039,CVCL_0218,Bowel,TP53,Hom,Frameshift,p.Y103fs,LoF,Suppressor
-COLO 205,ACH-001039,CVCL_0218,Bowel,TP53,Hom,Frameshift,p.Y107fs,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ACVR2A,Het,Stopgain,p.E112*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.I2167S,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Stopgain,p.L665*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.N2720K,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.R168I,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.S1864Y,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ARID1A,Het,Stopgain,p.R1772*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.E1133K,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Stopgain,p.E277*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.L1439I,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Stopgain,p.R250*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.R337C,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,B2M,Het,Stopgain,p.E56*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.D1177N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.E3342K,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.K817N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.K981N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.L2136V,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.P288S,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.R2896C,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,CDKN2A,Het,Missense,p.A36G,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,EP300,Het,Stopgain,p.E465*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,EP300,Het,Missense,p.L1584R,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,FBXW7,Het,Missense,p.R609W,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,JAK1,Het,Missense,p.R755Q,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,KMT2D,Het,Missense,p.T2131P,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,KRAS,Het,Missense,p.A146T,GoF,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,MSH6,Het,Missense,p.K885N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,MTOR,Het,Missense,p.I2500M,GoF,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,MYCL,Het,Missense,p.R357I,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,NF1,Het,Missense,p.K609N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,NF2,Het,Missense,p.K99T,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3CB,Het,Missense,p.R149Q,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3CB,Het,Missense,p.R562Q,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3R1,Het,Stopgain,p.R98*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3R1,Het,Splice_site,,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PMS2,Het,Missense,p.A854T,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PMS2,Het,Missense,p.D286E,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,POLE,Het,Missense,p.P286R,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PRDM2,Het,Missense,p.L595V,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PRDM2,Het,Missense,p.S470Y,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.F341V,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.R130Q,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.Y46C,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,PTPN11,Het,Missense,p.I54T,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,RAF1,Het,Missense,p.S257L,GoF,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Stopgain,p.E137*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Missense,p.F473C,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Missense,p.K80N,,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD2,Het,Missense,p.R321Q,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD2,Het,Missense,p.S276L,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD3,Het,Missense,p.S222L,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,SOS1,Het,Missense,p.I736R,,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,TP53,Het,Stopgain,p.R213*,LoF,Suppressor
-HCC-2998,ACH-001081,CVCL_1266,Bowel,XPO1,Het,Missense,p.E571K,GoF,Oncogene
-HCC-2998,ACH-001081,CVCL_1266,Bowel,XPO1,Het,Missense,p.R712I,,Oncogene
-NCI-H1385,ACH-000737,CVCL_1466,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-SW1463,ACH-000470,CVCL_1718,Bowel,APC,Hom,Frameshift,p.V452fs,LoF,Suppressor
-SW1463,ACH-000470,CVCL_1718,Bowel,ARID1A,Het,Missense,p.L2042V,,Suppressor
-SW1463,ACH-000470,CVCL_1718,Bowel,FBXW7,Het,Missense,p.R399Q,LoF,Suppressor
-SW1463,ACH-000470,CVCL_1718,Bowel,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
-SW1463,ACH-000470,CVCL_1718,Bowel,MTOR,Het,Missense,p.A1099G,,Oncogene
-SW1463,ACH-000470,CVCL_1718,Bowel,RNF43,Het,Missense,p.R223P,,Suppressor
-SW1463,ACH-000470,CVCL_1718,Bowel,SMAD4,Hom,Missense,p.R265G,LoF,Suppressor
-SW1463,ACH-000470,CVCL_1718,Bowel,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,ACVR2A,Hom,Splice_site,,LoF,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,APC,Het,Stopgain,p.R213*,LoF,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,ATM,Het,Missense,p.H448R,,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,EGFR,Het,Missense,p.C186S,,Oncogene
-SW837,ACH-000421,CVCL_1729,Bowel,EGFR,Het,Missense,p.R264G,,Oncogene
-SW837,ACH-000421,CVCL_1729,Bowel,FBXW7,Hom,Frameshift,p.L323fs,LoF,Suppressor
-SW837,ACH-000421,CVCL_1729,Bowel,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-SW837,ACH-000421,CVCL_1729,Bowel,TP53,Hom,Missense,p.R248W,LoF,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,CDKN2A,Het,Missense,p.D23P,,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,CDKN2A,Hom,Missense,p.H15R,LoF,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,EGFR,Het,Missense,p.L858R,,Oncogene
-LU65,ACH-000438,CVCL_1392,Lung,KRAS,,Gain,GAIN,GoF,Oncogene
-LU65,ACH-000438,CVCL_1392,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-LU65,ACH-000438,CVCL_1392,Lung,RB1,Hom,Stopgain,p.S82*,LoF,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,STK11,Hom,Splice_site,,LoF,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,TP53,Het,Missense,p.E11Q,,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,TP53,Hom,Splice_site,p.T125T,LoF,Suppressor
-LU65,ACH-000438,CVCL_1392,Lung,WNK2,Hom,Missense,p.V1821M,,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,BRCA2,Het,Missense,p.M784V,,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,EP300,Hom,Frameshift,p.I967fs,LoF,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-LU99,ACH-000444,CVCL_3015,Lung,NF2,Hom,Splice_site,,LoF,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,PIK3CA,Het,Missense,p.T1025A,GoF,Oncogene
-LU99,ACH-000444,CVCL_3015,Lung,POLE,Het,Missense,p.D535Y,LoF,Suppressor
-LU99,ACH-000444,CVCL_3015,Lung,ZFHX3,Hom,Missense,p.E1900A,,Suppressor
-HT-29,ACH-000552,CVCL_0320,Bowel,APC,Het,Stopgain,p.E853*,LoF,Suppressor
-HT-29,ACH-000552,CVCL_0320,Bowel,APC,Het,Frameshift,p.T1556fs,LoF,Suppressor
-HT-29,ACH-000552,CVCL_0320,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-HT-29,ACH-000552,CVCL_0320,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
-HT-29,ACH-000552,CVCL_0320,Bowel,PIK3CA,Het,Missense,p.P449T,,Oncogene
-HT-29,ACH-000552,CVCL_0320,Bowel,SMAD4,Hom,Stopgain,p.Q311*,LoF,Suppressor
-HT-29,ACH-000552,CVCL_0320,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
-HT-29,ACH-000552,CVCL_0320,Bowel,ZFHX3,Het,Missense,p.I1217M,,Suppressor
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,APC,Het,Missense,p.D1810E,,Suppressor
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,ATM,Het,Missense,p.R924W,,Suppressor
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,CCND1,,Gain,GAIN,GoF,Oncogene
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,ERBB2,,Gain,GAIN,GoF,Oncogene
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,KMT2D,Het,Missense,p.Q3904H,,Suppressor
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,SMARCA4,Het,Missense,p.V1207I,,Suppressor
-KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,TP53,Hom,Missense,p.R337C,LoF,Suppressor
-NCI-H358,ACH-000860,CVCL_1559,Lung,ERBB3,Het,Missense,p.R421K,,Oncogene
-NCI-H358,ACH-000860,CVCL_1559,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-NCI-H358,ACH-000860,CVCL_1559,Lung,POLE,Het,Missense,p.V1270F,,Suppressor
-NCI-H358,ACH-000860,CVCL_1559,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
-NCI-H358,ACH-000860,CVCL_1559,Lung,ZFHX3,Het,Missense,p.R1402C,LoF,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,ATM,Het,Stopgain,p.E2943*,LoF,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,CDKN2A,Hom,Stopgain,p.C21*,LoF,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,CHEK2,Het,Missense,p.D207Y,,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-NCI-H1373,ACH-000845,CVCL_1465,Lung,NF1,Het,Missense,p.I1806M,LoF,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,TP53,Hom,Stopgain,p.E339*,LoF,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,TP53,Hom,Missense,p.P47L,,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.G431R,,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.P1097S,,Suppressor
-NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.S1520I,,Suppressor
-Calu-1,ACH-000511,CVCL_0608,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-Calu-1,ACH-000511,CVCL_0608,Lung,SETD1B,Het,Missense,p.Q1589P,,Suppressor
-Calu-1,ACH-000511,CVCL_0608,Lung,TERT,,Promoter,1-124C>T,GoF,Oncogene
-Calu-1,ACH-000511,CVCL_0608,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Hom,Frameshift,p.I1417fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Missense,p.K993N,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Stopgain,p.R2166*,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Missense,p.R727M,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,B2M,Het,Stopgain,p.Y30*,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,B2M,Het,Splice_site,,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Missense,p.L1053S,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Missense,p.R2784Q,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,CHEK2,Het,Missense,p.A247D,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,CHEK2,Het,Missense,p.R145W,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,EP300,Het,Stopgain,p.E1014*,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,EP300,Het,Missense,p.R838C,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,ERBB3,Het,Missense,p.R667H,,Oncogene
-DLD-1,ACH-001061,CVCL_0248,Bowel,FBXW7,Het,Missense,p.P29S,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,GNAS,Het,Missense,p.K338N,,Oncogene
-DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.E1517D,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.E1667D,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.F5284L,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.L2304M,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.P1931H,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
-DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Frameshift,p.D1171fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Frameshift,p.L290fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Missense,p.R1172del,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Missense,p.Y469F,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,NF1,Het,Missense,p.A2596V,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3CA,Het,Missense,p.D549N,GoF,Oncogene
-DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
-DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3R1,Het,Missense,p.P312L,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,RNF43,Het,Missense,p.L214M,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Missense,p.D159N,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Missense,p.Q780H,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,SMARCA4,Het,Missense,p.R885C,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,TGFBR2,Het,Frameshift,p.K128fs,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,TP53,Het,Missense,p.S241F,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,TP53,Het,Splice_site,,LoF,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,ZFHX3,Het,Missense,p.P1707H,,Suppressor
-DLD-1,ACH-001061,CVCL_0248,Bowel,ZFHX3,Het,Missense,p.P3069T,LoF,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,ACVR2A,Het,Missense,p.R400H,LoF,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Missense,p.M431I,,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Stopgain,p.Q625*,LoF,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,KRAS,Het,Missense,p.G12S,GoF,Oncogene
-LS123,ACH-000501,CVCL_1383,Bowel,MTOR,Het,Missense,p.A1099G,,Oncogene
-LS123,ACH-000501,CVCL_1383,Bowel,SMAD4,Hom,Stopgain,p.E234*,LoF,Suppressor
-LS123,ACH-000501,CVCL_1383,Bowel,TP53,Hom,Missense,p.R175H,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,APC,Hom,Stopgain,p.Q1367*,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,CHEK2,,Deletion,DEL,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,CTNNB1,Het,Missense,p.G245A,,Oncogene
-Caco-2,ACH-000003,CVCL_0025,Bowel,EP300,,Deletion,DEL,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,NF2,,Deletion,DEL,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,SMAD4,Hom,Missense,p.D351H,,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,SMARCB1,,Deletion,DEL,LoF,Suppressor
-Caco-2,ACH-000003,CVCL_0025,Bowel,TP53,Hom,Stopgain,p.E204*,LoF,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Frameshift,p.I1417fs,LoF,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Missense,p.K993N,,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Stopgain,p.R2166*,LoF,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Missense,p.R727M,LoF,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,CTNNB1,,Missense,p.V79I,,Oncogene
-HCT-8,ACH-001084,CVCL_2478,Bowel,KRAS,,Missense,p.G13D,GoF,Oncogene
-HCT-8,ACH-001084,CVCL_2478,Bowel,PIK3CA,,Missense,p.D549N,GoF,Oncogene
-HCT-8,ACH-001084,CVCL_2478,Bowel,PIK3CA,,Missense,p.E545K,GoF,Oncogene
-HCT-8,ACH-001084,CVCL_2478,Bowel,SMAD2,,Frameshift,p.P164fs,LoF,Suppressor
-HCT-8,ACH-001084,CVCL_2478,Bowel,SMAD3,,Missense,p.V244I,,Suppressor
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,APC,Het,Frameshift,p.F1089fs,LoF,Suppressor
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,APC,Het,Frameshift,p.P1443fs,LoF,Suppressor
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,EP300,Het,Missense,p.P842S,,Suppressor
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,GNAS,Het,Missense,p.R201C,,Oncogene
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,KRAS,Het,Missense,p.G12V,GoF,Oncogene
-SK-CO-1,ACH-000400,CVCL_0626,Bowel,SETD1B,Het,Missense,p.Q1589P,,Suppressor
-SW480,ACH-000842,CVCL_0546,Bowel,APC,Hom,Stopgain,p.Q1338*,LoF,Suppressor
-SW480,ACH-000842,CVCL_0546,Bowel,ATM,Het,Missense,p.R2461P,LoF,Suppressor
-SW480,ACH-000842,CVCL_0546,Bowel,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
-SW480,ACH-000842,CVCL_0546,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
-SW480,ACH-000842,CVCL_0546,Bowel,TP53,Hom,Missense,p.P309S,LoF,Suppressor
-SW480,ACH-000842,CVCL_0546,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
-SW 1573,ACH-000677,CVCL_1720,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-SW 1573,ACH-000677,CVCL_1720,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-SW 1573,ACH-000677,CVCL_1720,Lung,CTNNB1,Het,Missense,p.S33F,GoF,Oncogene
-SW 1573,ACH-000677,CVCL_1720,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
-SW 1573,ACH-000677,CVCL_1720,Lung,PIK3CA,Het,Missense,p.K111E,GoF,Oncogene
-SW 1573,ACH-000677,CVCL_1720,Lung,PRDM2,Hom,Missense,p.L824Q,,Suppressor
-SW 1573,ACH-000677,CVCL_1720,Lung,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
-SW 1573,ACH-000677,CVCL_1720,Lung,SMARCB1,Hom,Splice_site,,LoF,Suppressor
-HCC1143,ACH-000374,CVCL_1245,Breast,AKT1,,Gain,GAIN,GoF,Oncogene
-HCC1143,ACH-000374,CVCL_1245,Breast,CCND1,,Gain,GAIN,GoF,Oncogene
-HCC1143,ACH-000374,CVCL_1245,Breast,FGFR2,Het,Missense,p.R203C,,Oncogene
-HCC1143,ACH-000374,CVCL_1245,Breast,SMARCA4,Het,Missense,p.R1323H,LoF,Suppressor
-HCC1143,ACH-000374,CVCL_1245,Breast,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
-HS-578T,ACH-000148,CVCL_0332,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-HS-578T,ACH-000148,CVCL_0332,Breast,HNF1A,Het,Missense,p.K273E,LoF,Suppressor
-HS-578T,ACH-000148,CVCL_0332,Breast,HRAS,Het,Missense,p.G12D,GoF,Oncogene
-HS-578T,ACH-000148,CVCL_0332,Breast,NF1,Het,Missense,p.G2724R,,Suppressor
-HS-578T,ACH-000148,CVCL_0332,Breast,PIK3R1,Hom,Missense,p.89_90insN,,Suppressor
-HS-578T,ACH-000148,CVCL_0332,Breast,TP53,Hom,Missense,p.V157F,LoF,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,APC,Het,Frameshift,p.Q1429fs,LoF,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,APC,Het,Stopgain,p.Q264*,LoF,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,FBXW7,Het,Missense,p.H380Y,LoF,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,KRAS,Het,Missense,p.G12A,GoF,Oncogene
-SW1116,ACH-000489,CVCL_0544,Bowel,TP53,Hom,Missense,p.A159D,LoF,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,WNK2,Het,Missense,p.A1048G,,Suppressor
-SW1116,ACH-000489,CVCL_0544,Bowel,ZFHX3,Het,Missense,p.G918R,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Frameshift,p.M1431fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Stopgain,p.R1114*,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Missense,p.R2816Q,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,ARID1A,Het,Frameshift,p.F1924fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,B2M,Hom,Frameshift,p.L15fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,CHEK2,Het,Frameshift,p.T389fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,FBXW7,Het,Missense,p.R425C,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,FGFR3,Het,Missense,p.I533V,,Oncogene
-LoVo,ACH-000950,CVCL_0399,Bowel,HNF1A,Het,Missense,p.V446M,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,KMT2D,Het,Frameshift,p.H77fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
-LoVo,ACH-000950,CVCL_0399,Bowel,NF1,Het,Missense,p.R1674Q,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,PIK3CB,Het,Missense,p.E1051K,,Oncogene
-LoVo,ACH-000950,CVCL_0399,Bowel,PRDM2,Het,Missense,p.S1618G,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,PRDM2,Het,Frameshift,p.V1490fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,RAF1,Het,Missense,p.V98A,,Oncogene
-LoVo,ACH-000950,CVCL_0399,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,SETD1B,Het,Missense,p.V1447I,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,SMAD2,Het,Missense,p.A292V,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,WNK2,Het,Missense,p.R2073C,,Suppressor
-LoVo,ACH-000950,CVCL_0399,Bowel,WNK2,Het,Missense,p.V1544A,,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,APC,Het,Stopgain,p.Q1429*,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,APC,Het,Stopgain,p.R1114*,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,ARID1A,Het,Missense,p.G701A,,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,ATM,Het,Stopgain,p.Q2210*,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,EP300,Het,Splice_site,,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,KMT2D,Het,Missense,p.N2030H,,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,KMT2D,Het,Missense,p.R5120C,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,KRAS,Het,Missense,p.Q61L,GoF,Oncogene
-SW948,ACH-000680,CVCL_0632,Bowel,PIK3CA,Hom,Missense,p.E542K,GoF,Oncogene
-SW948,ACH-000680,CVCL_0632,Bowel,SMAD4,Hom,Missense,p.D441Y,LoF,Suppressor
-SW948,ACH-000680,CVCL_0632,Bowel,TP53,Hom,Frameshift,p.T118fs,LoF,Suppressor
-LS 174T,,CVCL_1384,Bowel,CTNNB1,Hom,Missense,p.S45F,GoF,Oncogene
-LS 174T,,CVCL_1384,Bowel,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-LS 174T,,CVCL_1384,Bowel,PIK3CA,,Missense,p.H1047R,GoF,Oncogene
-SW1417,ACH-000236,CVCL_1717,Bowel,APC,Hom,Stopgain,p.R1450*,LoF,Suppressor
-SW1417,ACH-000236,CVCL_1717,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-SW1417,ACH-000236,CVCL_1717,Bowel,PIK3R1,Hom,Deletion,DEL,LoF,Suppressor
-SW1417,ACH-000236,CVCL_1717,Bowel,TP53,Hom,Frameshift,p.C238fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,ACVR2A,Het,Frameshift,p.K437fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,ARID1A,Het,Frameshift,p.P1115fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,B2M,Het,Stopgain,p.R117*,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-RKO,ACH-000943,CVCL_0504,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,EP300,Het,Frameshift,p.K292fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,HNF1A,Het,Frameshift,p.P379fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Frameshift,p.G1960fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Stopgain,p.G3465*,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Missense,p.L1600P,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Missense,p.L5056P,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Frameshift,p.P2550fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,MSH6,Het,Frameshift,p.Y1066fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Frameshift,p.N2320fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Missense,p.V2184A,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Frameshift,p.Y628fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,NF2,Het,Frameshift,p.P275fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
-RKO,ACH-000943,CVCL_0504,Bowel,POLE,Het,Missense,p.K995E,,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,PRDM2,Het,Missense,p.S876G,,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,RNF43,Hom,Frameshift,p.G659fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,RNF43,Het,Missense,p.H549N,,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,SETD1B,Het,Missense,p.T1700A,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,SMAD3,Het,Missense,p.A13T,,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,TGFBR2,Het,Frameshift,p.K128fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,ZFHX3,Het,Frameshift,p.F1596fs,LoF,Suppressor
-RKO,ACH-000943,CVCL_0504,Bowel,ZFHX3,Het,Missense,p.S112N,,Suppressor
-T84,ACH-000381,CVCL_0555,Bowel,APC,Hom,Frameshift,p.L1488fs,LoF,Suppressor
-T84,ACH-000381,CVCL_0555,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
-T84,ACH-000381,CVCL_0555,Bowel,PIK3CA,Het,Missense,p.E542K,GoF,Oncogene
-T84,ACH-000381,CVCL_0555,Bowel,SMAD4,Hom,Missense,p.K244N,LoF,Suppressor
-T84,ACH-000381,CVCL_0555,Bowel,TP53,Hom,Splice_site,,LoF,Suppressor
-T84,ACH-000381,CVCL_0555,Bowel,ZFHX3,Het,Missense,p.A3398P,,Suppressor
-SHP-77,ACH-000790,CVCL_1693,Lung,ABL1,Het,Missense,p.V1128E,,Oncogene
-SHP-77,ACH-000790,CVCL_1693,Lung,ACVR2A,Hom,Missense,p.L147R,LoF,Suppressor
-SHP-77,ACH-000790,CVCL_1693,Lung,ARID1A,Het,Missense,p.P253S,,Suppressor
-SHP-77,ACH-000790,CVCL_1693,Lung,EGFR,Het,Missense,p.Q656R,,Oncogene
-SHP-77,ACH-000790,CVCL_1693,Lung,KMT2D,Hom,Missense,p.Q3950R,,Suppressor
-SHP-77,ACH-000790,CVCL_1693,Lung,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
-SHP-77,ACH-000790,CVCL_1693,Lung,RAC1,Het,Missense,p.Y32C,,Oncogene
-SHP-77,ACH-000790,CVCL_1693,Lung,SETD1B,Het,Missense,p.T482M,,Suppressor
-SHP-77,ACH-000790,CVCL_1693,Lung,TP53,Hom,Missense,p.C176W,LoF,Suppressor
-SW 900,ACH-000669,CVCL_1731,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-SW 900,ACH-000669,CVCL_1731,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-SW 900,ACH-000669,CVCL_1731,Lung,KMT2D,Hom,Stopgain,p.K5522*,LoF,Suppressor
-SW 900,ACH-000669,CVCL_1731,Lung,KRAS,Het,Missense,p.G12V,GoF,Oncogene
-SW 900,ACH-000669,CVCL_1731,Lung,SMAD3,Hom,Missense,p.K334E,LoF,Suppressor
-SW 900,ACH-000669,CVCL_1731,Lung,TP53,Hom,Stopgain,p.Q167*,LoF,Suppressor
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,ARID1A,Het,Missense,p.P1723L,,Suppressor
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,ARID1A,Hom,Stopgain,p.Q321*,LoF,Suppressor
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
-MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,TP53,Hom,Missense,p.R248W,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.E2550Q,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Hom,Frameshift,p.I1417fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.I1779M,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.K1561N,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.K993N,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Stopgain,p.R2166*,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.R727M,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ARID1A,Het,Missense,p.R270H,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ATM,Het,Missense,p.E586D,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,B2M,Het,Stopgain,p.Y30*,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,B2M,Het,Splice_site,,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Missense,p.A487V,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Missense,p.R2784Q,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,CHEK2,Het,Missense,p.A247D,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,CHEK2,Het,Missense,p.R145W,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,EP300,Hom,Stopgain,p.E1014*,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ERBB3,Het,Missense,p.R667H,,Oncogene
-HCT15,ACH-000997,CVCL_0292,Bowel,GNAS,Het,Missense,p.K338N,,Oncogene
-HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.E1517D,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.P1152H,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.P1931H,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
-HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Frameshift,p.D1171fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Frameshift,p.L290fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Missense,p.R1172del,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Missense,p.T1189I,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.A2596V,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.A74D,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.P2456S,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,PIK3CA,Het,Missense,p.D549N,GoF,Oncogene
-HCT15,ACH-000997,CVCL_0292,Bowel,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
-HCT15,ACH-000997,CVCL_0292,Bowel,PIK3R1,Het,Missense,p.P312L,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,POLE,Het,Missense,p.A1375V,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,PRDM2,Het,Stopgain,p.E1259*,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,PRDM2,Het,Stopgain,p.Q1699*,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,RNF43,Het,Missense,p.L214M,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,SETD1B,Het,Missense,p.D159N,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,SETD1B,Het,Missense,p.Q780H,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,SMARCA4,Het,Missense,p.R885C,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,TP53,Het,Missense,p.S241F,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,TP53,Het,Splice_site,,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,WNK2,Het,Missense,p.V1971M,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Frameshift,p.E763fs,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.P1707H,,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.P3069T,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.R1402C,LoF,Suppressor
-HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.S1180N,,Suppressor
-CFPAC-1,ACH-000138,CVCL_1119,Pancreas,KRAS,Het,Missense,p.G12V,GoF,Oncogene
-CFPAC-1,ACH-000138,CVCL_1119,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
-CFPAC-1,ACH-000138,CVCL_1119,Pancreas,TP53,Hom,Missense,p.C242R,LoF,Suppressor
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,CDKN2A,Het,Frameshift,p.L27fs,LoF,Suppressor
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,FBXW7,Het,Missense,p.R385C,LoF,Suppressor
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,KRAS,Hom,Missense,p.G12D,GoF,Oncogene
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,RNF43,Hom,Stopgain,p.S720*,LoF,Suppressor
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,SMAD4,Hom,Missense,p.R100T,LoF,Suppressor
-AsPC-1,ACH-000222,CVCL_0152,Pancreas,TP53,Hom,Frameshift,p.C135fs,LoF,Suppressor
-Panc 02.13,ACH-000031,CVCL_1634,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-Panc 02.13,ACH-000031,CVCL_1634,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-Panc 02.13,ACH-000031,CVCL_1634,Pancreas,KRAS,Het,Missense,p.Q61R,GoF,Oncogene
-Panc 02.13,ACH-000031,CVCL_1634,Pancreas,SMARCA4,Het,Missense,p.T910M,LoF,Suppressor
-Panc 02.13,ACH-000031,CVCL_1634,Pancreas,TP53,Hom,Missense,p.R273C,LoF,Suppressor
-Hs 766T,ACH-000178,CVCL_0334,Pancreas,ARID1A,Het,Stopgain,p.Q538*,LoF,Suppressor
-Hs 766T,ACH-000178,CVCL_0334,Pancreas,CDKN2A,Hom,Splice_site,,LoF,Suppressor
-Hs 766T,ACH-000178,CVCL_0334,Pancreas,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
-Hs 766T,ACH-000178,CVCL_0334,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,BRAF,Het,Missense,p.V487_492NA,,Oncogene
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,EP300,Het,Stopgain,p.R397*,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,RNF43,Hom,Missense,p.S495Y,,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,SMARCB1,Hom,Deletion,DEL,LoF,Suppressor
-BxPC-3,ACH-000535,CVCL_0186,Pancreas,TP53,Hom,Missense,p.Y220C,LoF,Suppressor
-PANC-1,ACH-000164,CVCL_0480,Pancreas,AKT2,,Gain,GAIN,GoF,Oncogene
-PANC-1,ACH-000164,CVCL_0480,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-PANC-1,ACH-000164,CVCL_0480,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-PANC-1,ACH-000164,CVCL_0480,Pancreas,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-PANC-1,ACH-000164,CVCL_0480,Pancreas,TP53,Hom,Missense,p.R273H,LoF,Suppressor
-KLE,ACH-000293,CVCL_1329,Uterus,AKT2,,Gain,GAIN,GoF,Oncogene
-KLE,ACH-000293,CVCL_1329,Uterus,CCNE1,,Gain,GAIN,GoF,Oncogene
-KLE,ACH-000293,CVCL_1329,Uterus,FBXW7,Het,Missense,p.R399Q,LoF,Suppressor
-KLE,ACH-000293,CVCL_1329,Uterus,KRAS,,Gain,GAIN,GoF,Oncogene
-KLE,ACH-000293,CVCL_1329,Uterus,TP53,Hom,Missense,p.R175H,LoF,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,ACVR2A,Het,Missense,p.S17F,,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,ATM,Het,Missense,p.E2468K,LoF,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,BRCA2,Het,Stopgain,p.S3094*,LoF,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,ERBB2,,Gain,GAIN,GoF,Oncogene
-BT-474,ACH-000927,CVCL_0179,Breast,HNF1A,Het,Stopgain,p.Q495*,LoF,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,KMT2D,Het,Missense,p.E1623K,,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,LASP1,,Gain,GAIN,GoF,Oncogene
-BT-474,ACH-000927,CVCL_0179,Breast,MAPK1,Het,Missense,p.H61Q,,Oncogene
-BT-474,ACH-000927,CVCL_0179,Breast,PIK3CA,Het,Missense,p.K111N,GoF,Oncogene
-BT-474,ACH-000927,CVCL_0179,Breast,TGFBR2,Het,Missense,p.M36I,,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,TP53,Hom,Missense,p.E285K,LoF,Suppressor
-BT-474,ACH-000927,CVCL_0179,Breast,WNK2,Het,Missense,p.E398Q,,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,APC,Het,Missense,p.R2714C,,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,ARID1A,Het,Frameshift,p.A339fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,B2M,Het,Stopgain,p.Q22*,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,B2M,Het,Frameshift,p.V69fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,BRCA2,Het,Frameshift,p.K1691fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,CTNNB1,Het,Missense,p.S33Y,GoF,Oncogene
-SW48,ACH-000958,CVCL_1724,Bowel,EGFR,Het,Missense,p.G674S,GoF,Oncogene
-SW48,ACH-000958,CVCL_1724,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,EP300,Het,Missense,p.T594M,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,FBXW7,Het,Frameshift,p.S588fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,KMT2D,Het,Stopgain,p.R4904*,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,KMT2D,Het,Frameshift,p.R755fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,MAP2K1,Het,Missense,p.D175G,,Oncogene
-SW48,ACH-000958,CVCL_1724,Bowel,MAP2K1,Het,Missense,p.Q56P,GoF,Oncogene
-SW48,ACH-000958,CVCL_1724,Bowel,PIK3CA,Het,Missense,p.G914R,GoF,Oncogene
-SW48,ACH-000958,CVCL_1724,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,RNF43,Het,Frameshift,p.V299fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,SMARCA4,Het,Missense,p.A703V,,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
-SW48,ACH-000958,CVCL_1724,Bowel,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,APC,Het,Stopgain,p.Q789*,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,APC,Het,Frameshift,p.T1556fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,ARID1A,Het,Frameshift,p.P1326fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,BRCA2,Het,Missense,p.E3111K,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,CHEK2,Het,Missense,p.P85H,,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,EP300,Het,Frameshift,p.H2324fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,ERBB2,Het,Missense,p.E744K,,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,FBXW7,Het,Missense,p.R425H,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,GNAS,Het,Missense,p.R160C,,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,GNAS,Het,Missense,p.R356C,,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,HNF1A,Het,Missense,p.L408I,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Missense,p.E1018D,,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Missense,p.G4437V,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Frameshift,p.P853fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,MAPK3,Het,Missense,p.S172C,,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,MET,Het,Missense,p.T86I,,Oncogene
-LS411N,ACH-000985,CVCL_1385,Bowel,NF1,Het,Missense,p.T2784I,,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,PTEN,Het,Frameshift,p.C105fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,PTEN,Het,Frameshift,p.K164fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Frameshift,p.K42fs,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Missense,p.V65A,,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Missense,p.V723A,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,TP53,Hom,Stopgain,p.Y126*,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,WNK2,Het,Splice_site,p.S612S,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,WNK2,Het,Splice_site,,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,ZFHX3,Het,Missense,p.C3029Y,LoF,Suppressor
-LS411N,ACH-000985,CVCL_1385,Bowel,ZFHX3,Het,Missense,p.P802L,,Suppressor
-HOP62,ACH-000861,CVCL_1285,Lung,B2M,Het,Missense,p.E70Q,,Suppressor
-HOP62,ACH-000861,CVCL_1285,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-HOP62,ACH-000861,CVCL_1285,Lung,MSH6,Het,Missense,p.E221D,,Suppressor
-HOP62,ACH-000861,CVCL_1285,Lung,POLE,Het,Missense,p.K604N,,Suppressor
-HOP62,ACH-000861,CVCL_1285,Lung,RAF1,Het,Missense,p.R143Q,,Oncogene
-HOP62,ACH-000861,CVCL_1285,Lung,TERT,Het,Promoter,1-124C>T,GoF,Oncogene
-HOP62,ACH-000861,CVCL_1285,Lung,TP53,Hom,Splice_site,,LoF,Suppressor
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,APC,Het,Missense,p.S770P,,Suppressor
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,ERBB2,Het,Missense,p.R678Q,GoF,Oncogene
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,FGFR3,Het,Missense,p.K651E,GoF,Oncogene
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,PIK3CA,Het,Missense,p.P124L,,Oncogene
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,PTEN,Hom,Frameshift,p.N212fs,LoF,Suppressor
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,RB1,Hom,Splice_site,,LoF,Suppressor
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TERT,,Promoter,1-124C>T,GoF,Oncogene
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TP53,Het,Missense,p.E271K,LoF,Suppressor
-J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TP53,Het,Missense,p.K320N,LoF,Suppressor
-CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,ARID1A,Het,Missense,p.P1144T,,Suppressor
-CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,PTEN,Hom,Missense,p.L112R,LoF,Suppressor
-CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,PTPN11,Het,Missense,p.R498W,GoF,Oncogene
-BT-20,ACH-000536,CVCL_0178,Breast,BRCA2,Hom,Missense,p.T3357R,,Suppressor
-BT-20,ACH-000536,CVCL_0178,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-BT-20,ACH-000536,CVCL_0178,Breast,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-BT-20,ACH-000536,CVCL_0178,Breast,EGFR,,Gain,GAIN,GoF,Oncogene
-BT-20,ACH-000536,CVCL_0178,Breast,NRAS,,Gain,GAIN,GoF,Oncogene
-BT-20,ACH-000536,CVCL_0178,Breast,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
-BT-20,ACH-000536,CVCL_0178,Breast,PIK3CA,Het,Missense,p.P539R,GoF,Oncogene
-BT-20,ACH-000536,CVCL_0178,Breast,RB1,Hom,Missense,p.I388S,LoF,Suppressor
-BT-20,ACH-000536,CVCL_0178,Breast,RB1,Het,Missense,p.P515L,LoF,Suppressor
-BT-20,ACH-000536,CVCL_0178,Breast,TP53,Hom,Missense,p.K132Q,LoF,Suppressor
-DU4475,ACH-000258,CVCL_1183,Breast,APC,Hom,Stopgain,p.E1577*,LoF,Suppressor
-DU4475,ACH-000258,CVCL_1183,Breast,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-DU4475,ACH-000258,CVCL_1183,Breast,RB1,Hom,Deletion,DEL,LoF,Suppressor
-DU4475,ACH-000258,CVCL_1183,Breast,SETD1B,Het,Missense,p.Q1402R,,Suppressor
-DU4475,ACH-000258,CVCL_1183,Breast,ZFHX3,Het,Missense,p.A2398D,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,APC,Het,Missense,p.R1788C,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,ARID1A,Het,Frameshift,p.K1094fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,BRAF,Het,Missense,p.D211G,,Oncogene
-LS 180,ACH-000957,CVCL_0397,Bowel,BRCA2,Het,Frameshift,p.T3033fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,CTNNB1,Hom,Missense,p.S45F,GoF,Oncogene
-LS 180,ACH-000957,CVCL_0397,Bowel,EP300,Het,Missense,p.G30V,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,JAK1,Het,Missense,p.R681W,,Oncogene
-LS 180,ACH-000957,CVCL_0397,Bowel,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-LS 180,ACH-000957,CVCL_0397,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
-LS 180,ACH-000957,CVCL_0397,Bowel,PRDM2,Het,Frameshift,p.V1490fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,PTEN,Het,Missense,p.I67K,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,RNF43,Het,Missense,p.K108E,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,RNF43,Het,Missense,p.R389H,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,SETD1B,Het,Frameshift,p.Q1589fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,STK11,Het,Missense,p.I46T,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,WNK2,Het,Missense,p.A1529T,,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
-LS 180,ACH-000957,CVCL_0397,Bowel,ZFHX3,Het,Missense,p.D3699G,LoF,Suppressor
-COLO 201,ACH-000253,CVCL_1987,Bowel,APC,Hom,Frameshift,p.T1556fs,LoF,Suppressor
-COLO 201,ACH-000253,CVCL_1987,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-COLO 201,ACH-000253,CVCL_1987,Bowel,CTNNB1,Hom,Missense,p.N287S,,Oncogene
-COLO 201,ACH-000253,CVCL_1987,Bowel,GNAS,Het,Missense,p.S95I,,Oncogene
-COLO 201,ACH-000253,CVCL_1987,Bowel,MTOR,Het,Missense,p.P1193L,,Oncogene
-COLO 201,ACH-000253,CVCL_1987,Bowel,TP53,Hom,Frameshift,p.Y103fs,LoF,Suppressor
-COLO 201,ACH-000253,CVCL_1987,Bowel,TP53,Hom,Frameshift,p.Y107fs,LoF,Suppressor
-HepG2/C3A,ACH-001021,CVCL_1098,Liver,ATM,Het,Missense,p.V2906I,,Suppressor
-HepG2/C3A,ACH-001021,CVCL_1098,Liver,EGFR,Het,Missense,p.C186S,,Oncogene
-HepG2/C3A,ACH-001021,CVCL_1098,Liver,ERBB3,Het,Missense,p.R421K,,Oncogene
-HepG2/C3A,ACH-001021,CVCL_1098,Liver,NRAS,Het,Missense,p.Q61L,GoF,Oncogene
-HepG2/C3A,ACH-001021,CVCL_1098,Liver,TERT,,Promoter,1-124C>T,GoF,Oncogene
-RPMI-7951,ACH-000348,CVCL_1666,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-RPMI-7951,ACH-000348,CVCL_1666,Skin,CDKN2A,Hom,Missense,p.L16R,LoF,Suppressor
-RPMI-7951,ACH-000348,CVCL_1666,Skin,PTEN,Hom,Deletion,DEL,LoF,Suppressor
-RPMI-7951,ACH-000348,CVCL_1666,Skin,TERT,,Promoter,242_243CC>TT,,Oncogene
-RPMI-7951,ACH-000348,CVCL_1666,Skin,TP53,Hom,Stopgain,p.S166*,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ACVR2A,Het,Frameshift,p.K437fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ARID1A,Het,Frameshift,p.Y551fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,CDKN2B,Het,Missense,p.A23V,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,FBXW7,Het,Missense,p.G104V,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KMT2D,Het,Missense,p.G4397V,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KMT2D,Het,Missense,p.P4209Q,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KRAS,Het,Missense,p.G13C,GoF,Oncogene
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,MSH6,Het,Missense,p.A35T,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,NF1,Het,Frameshift,p.P678fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PIK3CA,Het,Missense,p.H1047Y,GoF,Oncogene
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,POLE,Het,Missense,p.D2166N,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,POLE,Het,Missense,p.S828Y,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PRDM2,Het,Missense,p.E278D,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PTEN,Het,Frameshift,p.K267fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,RNF43,Het,Missense,p.C298Y,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,SETD1B,Het,Missense,p.E1078D,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,SMARCA4,Het,Stopgain,p.E419*,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,STK11,Hom,Frameshift,p.P281fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Stopgain,p.G1139*,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Missense,p.L71P,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Missense,p.S1520N,,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
-TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ZFHX3,Het,Missense,p.P2787L,,Suppressor
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,EP300,Hom,Frameshift,p.K1488fs,LoF,Suppressor
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,NF1,Het,Missense,p.G1417S,LoF,Suppressor
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,RNF43,Hom,Frameshift,p.M18fs,LoF,Suppressor
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,TGFBR2,Hom,Frameshift,p.S156fs,LoF,Suppressor
-Panc 10.05,ACH-000060,CVCL_1639,Pancreas,TP53,Hom,Missense,p.I255N,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,ABL1,Het,Missense,p.Y276C,,Oncogene
-HCT116,ACH-000971,CVCL_0291,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,ATM,Het,Missense,p.A1127V,,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,BRCA2,Het,Frameshift,p.I2675fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,CDKN2A,Het,Frameshift,p.E33fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,CDKN2A,Het,Frameshift,p.R24fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,CHEK2,Het,Missense,p.L355P,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,CTNNB1,Het,Missense,p.S45NA,,Oncogene
-HCT116,ACH-000971,CVCL_0291,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,EP300,Het,Frameshift,p.N1700fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,GNAS,Het,Missense,p.Y318C,,Oncogene
-HCT116,ACH-000971,CVCL_0291,Bowel,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,KMT2D,Het,Frameshift,p.R2443fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,KMT2D,Het,Missense,p.V160M,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
-HCT116,ACH-000971,CVCL_0291,Bowel,NF1,Het,Missense,p.P388T,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
-HCT116,ACH-000971,CVCL_0291,Bowel,PRDM2,Hom,Frameshift,p.V1490fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Het,Frameshift,p.R1623fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Het,Frameshift,p.S1055fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,SMARCA4,Het,Missense,p.L1163P,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,SMARCA4,Het,Frameshift,p.S122fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,WNK2,Het,Frameshift,p.H758fs,LoF,Suppressor
-HCT116,ACH-000971,CVCL_0291,Bowel,ZFHX3,Het,Missense,p.G3519S,,Suppressor
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,ATM,Het,Missense,p.E2351G,LoF,Suppressor
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,KRAS,Het,Missense,p.G12V,GoF,Oncogene
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,TP53,Hom,Splice_site,375+5G>T,LoF,Suppressor
-Panc 03.27,ACH-000139,CVCL_1635,Pancreas,ZFHX3,Hom,Missense,p.P802A,,Suppressor
-Hs 852.T,ACH-000274,CVCL_0950,Skin,CCND1,,Gain,GAIN,GoF,Oncogene
-Hs 852.T,ACH-000274,CVCL_0950,Skin,EGFR,,Gain,GAIN,GoF,Oncogene
-Hs 852.T,ACH-000274,CVCL_0950,Skin,FGFR3,,Gain,GAIN,GoF,Oncogene
-Hs 852.T,ACH-000274,CVCL_0950,Skin,NRAS,Het,Missense,p.G12V,GoF,Oncogene
-Hs 852.T,ACH-000274,CVCL_0950,Skin,POLE,Het,Missense,p.R2159H,,Suppressor
-Hs 852.T,ACH-000274,CVCL_0950,Skin,TERT,,Gain,GAIN,GoF,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CDKN2A,Het,Missense,p.D23P,,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CDKN2B,Het,Missense,p.D76A,LoF,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CTNNB1,Het,Missense,p.G34E,GoF,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Stopgain,p.E1025*,LoF,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Stopgain,p.E643*,LoF,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Missense,p.K350R,LoF,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,GNAS,Het,Missense,p.F219V,,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,NF1,Het,Missense,p.E1438G,LoF,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PIK3CA,Het,Missense,p.E453K,GoF,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PIK3CA,Het,Missense,p.E545A,GoF,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PRDM2,Het,Missense,p.P1326S,,Suppressor
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,SOS1,Het,Missense,p.E783G,,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,XPO1,Het,Missense,p.C585F,,Oncogene
-AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,ZFHX3,Het,Missense,p.F3474L,LoF,Suppressor
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,ERBB2,,Gain,GAIN,GoF,Oncogene
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,ERBB3,,Missense,p.T757K,,Oncogene
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,KMT2D,Het,Missense,p.S537F,,Suppressor
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,LASP1,,Gain,GAIN,GoF,Oncogene
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,SETD1B,Het,Missense,p.Q1589P,,Suppressor
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
-NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,ARID1A,Hom,Deletion,DEL,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,BRCA2,Het,Missense,p.E2292A,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,CDKN2A,Hom,Stopgain,p.R29*,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,MET,,Gain,GAIN,GoF,Oncogene
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,STK11,Het,Missense,p.P149L,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,TP53,,Missense,p.G262_269NA,,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,TP53,Het,Splice_site,,LoF,Suppressor
-SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,ZFHX3,Hom,Missense,p.S1608G,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ACVR2A,Het,Missense,p.A349T,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ACVR2A,Het,Missense,p.L329M,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Missense,p.G1544C,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Stopgain,p.Q1618*,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Stopgain,p.Q1898*,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Missense,p.Q404H,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ATM,Het,Missense,p.P2353H,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,BRAF,Het,Missense,p.R682Q,,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,EP300,Het,Missense,p.D1399N,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ERBB2,Het,Missense,p.T798I,GoF,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ERBB2,Het,Missense,p.V842I,GoF,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,KMT2D,Het,Missense,p.P2641H,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,MET,Het,Missense,p.V1350D,,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,MSH6,Het,Frameshift,p.F1088fs,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,MSH6,Het,Splice_site,,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,MTOR,Het,Missense,p.R2254M,,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,NF1,Het,Missense,p.L792I,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,PIK3CA,Het,Missense,p.G1049R,GoF,Oncogene
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,PMS2,Hom,Stopgain,p.R802*,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,PRDM2,Het,Missense,p.N1324I,,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,SETD1B,Het,Frameshift,p.P1361fs,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,SMAD4,Het,Missense,p.L344S,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,SMARCA4,Het,Frameshift,p.G271fs,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ZFHX3,Het,Stopgain,p.R1114*,LoF,Suppressor
-HEC-1-A,ACH-000954,CVCL_0293,Uterus,ZFHX3,Het,Frameshift,p.S2505fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,ARID1A,Het,Frameshift,p.Q758fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,BRCA2,Het,Missense,p.A3029T,,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Frameshift,p.A2119fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Missense,p.R1614W,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Missense,p.R1617W,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Frameshift,p.V1244fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,PIK3CA,Het,Missense,p.R88Q,GoF,Oncogene
-C-33 A,ACH-001333,CVCL_1094,Cervix,PTEN,Het,Stopgain,p.R130*,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,PTEN,Het,Stopgain,p.R233*,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,RB1,Hom,Splice_site,,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Missense,p.R980W,,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Missense,p.T482M,,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Missense,p.M527T,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Missense,p.Q1248R,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Stopgain,p.Q1537*,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,TP53,Hom,Missense,p.R273C,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,WNK2,Het,Missense,p.A678T,,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
-C-33 A,ACH-001333,CVCL_1094,Cervix,ZFHX3,Het,Frameshift,p.R1893fs,LoF,Suppressor
-SK-HEP-1,ACH-000361,CVCL_0525,Liver,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-SK-HEP-1,ACH-000361,CVCL_0525,Liver,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-SK-HEP-1,ACH-000361,CVCL_0525,Liver,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-SK-HEP-1,ACH-000361,CVCL_0525,Liver,NF2,Het,Missense,p.I264V,,Suppressor
-SK-HEP-1,ACH-000361,CVCL_0525,Liver,SMARCA4,Hom,Stopgain,p.E1582*,LoF,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,CDKN2A,Het,Missense,p.D23P,,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,EGFR,,Gain,GAIN,GoF,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,ERBB3,Het,Missense,p.E332K,GoF,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,FBXW7,Het,Missense,p.V619L,,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,FBXW7,Het,Stopgain,p.W593*,LoF,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,KMT2D,Het,Missense,p.L2398P,,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,KMT2D,Het,Missense,p.V361F,,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,KRAS,Het,Missense,p.G12A,GoF,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,MET,,Gain,GAIN,GoF,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,PIK3R1,Het,Stopgain,p.G71*,LoF,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,PTPN11,Het,Stopgain,p.R351*,,Oncogene
-NCI-H1573,ACH-000916,CVCL_1478,Lung,RNF43,Het,Missense,p.A605G,,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,SMARCA4,Hom,Stopgain,p.E1399*,LoF,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,STK11,Het,Missense,p.S216F,LoF,Suppressor
-NCI-H1573,ACH-000916,CVCL_1478,Lung,TP53,Hom,Missense,p.R248L,LoF,Suppressor
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,CCND1,,Gain,GAIN,GoF,Oncogene
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,EP300,Het,Missense,p.P989S,,Suppressor
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,NRAS,Het,Missense,p.Q61R,GoF,Oncogene
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,POLE,Het,Missense,p.T1052A,,Suppressor
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,SETD1B,Het,Frameshift,p.L1255fs,LoF,Suppressor
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,TERT,,Promoter,1-146C>T,GoF,Oncogene
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,TP53,Hom,Missense,p.G245S,LoF,Suppressor
-SK-MEL-2,ACH-001190,CVCL_0069,Skin,ZFHX3,Het,Frameshift,p.H3611fs,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,APC,Het,Stopgain,p.R232*,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,EGFR,Het,Missense,p.R264G,,Oncogene
-NCI-H1155,ACH-000980,CVCL_1456,Lung,EP300,Hom,Splice_site,,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,KMT2D,Het,Missense,p.A3561D,,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,KMT2D,Het,Missense,p.V38M,,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
-NCI-H1155,ACH-000980,CVCL_1456,Lung,LASP1,Het,Missense,p.A209V,,Oncogene
-NCI-H1155,ACH-000980,CVCL_1456,Lung,MSH6,Hom,Stopgain,p.R911*,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,NF2,Het,Missense,p.A403T,,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,PIK3CA,Het,Missense,p.D843E,,Oncogene
-NCI-H1155,ACH-000980,CVCL_1456,Lung,PTEN,Hom,Stopgain,p.R233*,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,RB1,Het,Stopgain,p.R467*,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,SMAD4,Het,Frameshift,p.R38fs,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,SMARCA4,Het,Missense,p.R466L,,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,SMARCA4,Het,Missense,p.S1238P,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,TP53,Hom,Missense,p.R273H,LoF,Suppressor
-NCI-H1155,ACH-000980,CVCL_1456,Lung,ZFHX3,Het,Missense,p.A896T,,Suppressor
-NCI-H460,ACH-000463,CVCL_0459,Lung,ARID1A,Hom,Missense,p.LI1917del,,Suppressor
-NCI-H460,ACH-000463,CVCL_0459,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-NCI-H460,ACH-000463,CVCL_0459,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-NCI-H460,ACH-000463,CVCL_0459,Lung,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
-NCI-H460,ACH-000463,CVCL_0459,Lung,MAP2K1,Het,Missense,p.Y134C,,Oncogene
-NCI-H460,ACH-000463,CVCL_0459,Lung,MYC,,Gain,GAIN,GoF,Oncogene
-NCI-H460,ACH-000463,CVCL_0459,Lung,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
-NCI-H460,ACH-000463,CVCL_0459,Lung,STK11,Hom,Stopgain,p.Q37*,LoF,Suppressor
-NCI-H460,ACH-000463,CVCL_0459,Lung,ZFHX3,Het,Missense,p.P3675Q,,Suppressor
-NCI-H1299,ACH-000510,CVCL_0060,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-NCI-H1299,ACH-000510,CVCL_0060,Lung,SMARCA4,Hom,Splice_site,,LoF,Suppressor
-NCI-H1299,ACH-000510,CVCL_0060,Lung,SOS1,Het,Missense,p.Y215H,,Oncogene
-NCI-H1299,ACH-000510,CVCL_0060,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
-NCI-H1299,ACH-000510,CVCL_0060,Lung,ZFHX3,Het,Missense,p.F3044V,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,BRCA2,Het,Missense,p.G2584V,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,CDKN2A,Hom,Splice_site,,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,LASP1,Het,Stopgain,p.E48*,,Oncogene
-NCI-H661,ACH-000853,CVCL_1577,Lung,PTPN11,Het,Missense,p.N58S,,Oncogene
-NCI-H661,ACH-000853,CVCL_1577,Lung,SMARCA4,Hom,Frameshift,p.L1161fs,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,TP53,Het,Missense,p.R158L,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,TP53,Het,Missense,p.S215I,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,WNK2,Hom,Frameshift,p.G64fs,LoF,Suppressor
-NCI-H661,ACH-000853,CVCL_1577,Lung,ZFHX3,Het,Missense,p.H2506P,,Suppressor
-NCI-H596,ACH-000628,CVCL_1571,Lung,KMT2D,Het,Missense,p.M4058V,,Suppressor
-NCI-H596,ACH-000628,CVCL_1571,Lung,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
-NCI-H596,ACH-000628,CVCL_1571,Lung,RB1,Hom,Frameshift,p.S182fs,LoF,Suppressor
-NCI-H596,ACH-000628,CVCL_1571,Lung,TGFBR2,Hom,Frameshift,p.S75fs,LoF,Suppressor
-NCI-H596,ACH-000628,CVCL_1571,Lung,TP53,Hom,Missense,p.G245C,LoF,Suppressor
-A-427,ACH-000757,CVCL_1055,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-A-427,ACH-000757,CVCL_1055,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-A-427,ACH-000757,CVCL_1055,Lung,CTNNB1,Hom,Missense,p.T41A,GoF,Oncogene
-A-427,ACH-000757,CVCL_1055,Lung,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-A-427,ACH-000757,CVCL_1055,Lung,POLE,Hom,Missense,p.R37L,,Suppressor
-A-427,ACH-000757,CVCL_1055,Lung,SMARCA4,Het,Missense,p.A1307D,LoF,Suppressor
-Panc 08.13,ACH-000417,CVCL_1638,Pancreas,ATM,Het,Missense,p.F1234S,LoF,Suppressor
-Panc 08.13,ACH-000417,CVCL_1638,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-Panc 08.13,ACH-000417,CVCL_1638,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-Panc 08.13,ACH-000417,CVCL_1638,Pancreas,KRAS,Hom,Missense,p.G12D,GoF,Oncogene
-Panc 08.13,ACH-000417,CVCL_1638,Pancreas,SMAD4,Hom,Frameshift,p.C123fs,LoF,Suppressor
-CHP-212,ACH-000120,CVCL_1125,Peripheral Nervous System,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-H4,ACH-000389,CVCL_1239,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-H4,ACH-000389,CVCL_1239,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-H4,ACH-000389,CVCL_1239,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
-H4,ACH-000389,CVCL_1239,CNS/Brain,TERT,,Promoter,1-124C>T,GoF,Oncogene
-A498,ACH-000555,CVCL_1056,Kidney,APC,Het,Missense,p.C1270R,LoF,Suppressor
-A498,ACH-000555,CVCL_1056,Kidney,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-A498,ACH-000555,CVCL_1056,Kidney,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-A498,ACH-000555,CVCL_1056,Kidney,PIK3CB,Het,Missense,p.D1067V,GoF,Oncogene
-A498,ACH-000555,CVCL_1056,Kidney,SMARCA4,Het,Missense,p.A923P,LoF,Suppressor
-A498,ACH-000555,CVCL_1056,Kidney,VHL,Hom,Frameshift,p.G144fs,LoF,Suppressor
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,POLE,Het,Missense,p.V1270F,,Suppressor
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
-SW 1088,ACH-000437,CVCL_1715,CNS/Brain,TP53,Hom,Missense,p.R273C,LoF,Suppressor
-BT-483,ACH-000818,CVCL_2319,Breast,APC,Het,Missense,p.T1160K,LoF,Suppressor
-BT-483,ACH-000818,CVCL_2319,Breast,NF1,Het,Missense,p.R1204W,LoF,Suppressor
-BT-483,ACH-000818,CVCL_2319,Breast,PIK3CA,Het,Missense,p.E542K,GoF,Oncogene
-BT-483,ACH-000818,CVCL_2319,Breast,TP53,Het,Missense,p.M246I,LoF,Suppressor
-BT-483,ACH-000818,CVCL_2319,Breast,WNK2,Het,Missense,p.L1162P,,Suppressor
-SNU-423,ACH-000493,CVCL_0366,Liver,ARID1A,Hom,Stopgain,p.G623*,LoF,Suppressor
-SNU-423,ACH-000493,CVCL_0366,Liver,RNF43,Het,Missense,p.I485V,,Suppressor
-SNU-423,ACH-000493,CVCL_0366,Liver,TERT,,Promoter,1-124C>T,GoF,Oncogene
-SNU-423,ACH-000493,CVCL_0366,Liver,TP53,Hom,Splice_site,,LoF,Suppressor
-SW 1271,ACH-000890,CVCL_1716,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-SW 1271,ACH-000890,CVCL_1716,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-SW 1271,ACH-000890,CVCL_1716,Lung,NRAS,Hom,Missense,p.Q61R,GoF,Oncogene
-SW 1271,ACH-000890,CVCL_1716,Lung,PMS2,Het,Missense,p.H88Y,,Suppressor
-SW 1271,ACH-000890,CVCL_1716,Lung,SMARCA4,Hom,Missense,p.N774K,LoF,Suppressor
-SW 1271,ACH-000890,CVCL_1716,Lung,TP53,Hom,Missense,p.C277F,LoF,Suppressor
-Hs 695T,ACH-000799,CVCL_0851,Skin,ATM,Hom,Stopgain,p.Q1825*,LoF,Suppressor
-Hs 695T,ACH-000799,CVCL_0851,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-Hs 695T,ACH-000799,CVCL_0851,Skin,BRCA2,Het,Missense,p.K2950N,,Suppressor
-Hs 695T,ACH-000799,CVCL_0851,Skin,NF1,Het,Stopgain,p.Q959*,LoF,Suppressor
-Hs 695T,ACH-000799,CVCL_0851,Skin,POLE,Het,Missense,p.V1270F,,Suppressor
-Hs 695T,ACH-000799,CVCL_0851,Skin,TERT,,Promoter,1-146C>T,GoF,Oncogene
-C32,ACH-000580,CVCL_1097,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-C32,ACH-000580,CVCL_1097,Skin,CDKN2A,Hom,Stoploss,Ter157Serext*13,,Suppressor
-C32,ACH-000580,CVCL_1097,Skin,PTEN,Hom,Deletion,DEL,LoF,Suppressor
-C32,ACH-000580,CVCL_1097,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,ATM,Het,Missense,p.S2581I,,Suppressor
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,BRCA2,Het,Missense,p.G2044V,,Suppressor
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,CTNNB1,,Gain,GAIN,GoF,Oncogene
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,FGFR2,,Gain,GAIN,GoF,Oncogene
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,KMT2D,Het,Missense,p.A3242P,,Suppressor
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,KMT2D,Het,Stopgain,p.E1747*,LoF,Suppressor
-KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,TP53,,Deletion,DEL,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Missense,p.P121S,,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Frameshift,p.Q372fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ATM,Het,Frameshift,p.L1154fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,BRCA2,Het,Missense,p.R1190W,,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,BRCA2,Het,Frameshift,p.S309fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,JAK1,Het,Frameshift,p.K860fs,,Oncogene
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Frameshift,p.A2119fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Missense,p.P2363del,,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Missense,p.R5030C,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KRAS,Het,Missense,p.G12D,GoF,Oncogene
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,PRDM2,Het,Missense,p.S67F,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SMAD3,Het,Frameshift,p.V380fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SMAD4,Het,Missense,p.R265H,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,TGFBR2,Het,Frameshift,p.S409fs,LoF,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,WNK2,Het,Missense,p.G1850C,,Suppressor
-SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,WNK2,Het,Missense,p.W547C,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,ARID1A,Het,Missense,p.LEMLRENT1836del,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,FBXW7,Het,Missense,p.R361W,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,FGFR2,Het,Missense,p.K82R,GoF,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,FGFR2,Hom,Missense,p.N321K,GoF,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,HRAS,Het,Missense,p.F82L,,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,KMT2D,Het,Frameshift,p.P2210fs,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,MAPK3,Het,Missense,p.P373S,,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,MET,Het,Missense,p.G344R,,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,PIK3R1,Het,Missense,p.R557_561NA,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,POLE,Het,Missense,p.S30L,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,PTEN,Hom,Frameshift,p.R130fs,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,SETD1B,Het,Frameshift,p.P749fs,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,SMARCA4,Het,Missense,p.P1456L,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,TERT,Het,Missense,p.D848G,,Oncogene
-AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Missense,p.G389W,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Missense,p.R213Q,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Frameshift,p.S90fs,LoF,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,WNK2,Het,Missense,p.P702S,,Suppressor
-AN3 CA,ACH-000940,CVCL_0028,Uterus,ZFHX3,Het,Frameshift,p.R1893fs,LoF,Suppressor
-NCI-H2347,ACH-000875,CVCL_1550,Lung,B2M,Hom,Stopgain,p.Q28*,LoF,Suppressor
-NCI-H2347,ACH-000875,CVCL_1550,Lung,EP300,Het,Missense,p.V5L,,Suppressor
-NCI-H2347,ACH-000875,CVCL_1550,Lung,KRAS,Het,Missense,p.L19F,GoF,Oncogene
-NCI-H2347,ACH-000875,CVCL_1550,Lung,NF1,Het,Missense,p.H31L,LoF,Suppressor
-NCI-H2347,ACH-000875,CVCL_1550,Lung,NRAS,Hom,Missense,p.Q61R,GoF,Oncogene
-NCI-H2347,ACH-000875,CVCL_1550,Lung,TP53,Hom,Splice_site,p.T125T,LoF,Suppressor
-NCI-H2347,ACH-000875,CVCL_1550,Lung,TP53,Hom,Synonymous_splicing,Thr125Thr,,Suppressor
-EKVX,ACH-000706,CVCL_1195,Lung,SMARCA4,Hom,Stopgain,p.Q418*,LoF,Suppressor
-EKVX,ACH-000706,CVCL_1195,Lung,STK11,Hom,Missense,p.S216F,LoF,Suppressor
-EKVX,ACH-000706,CVCL_1195,Lung,TP53,Hom,Stopgain,p.E204*,LoF,Suppressor
-EKVX,ACH-000706,CVCL_1195,Lung,VHL,Het,Missense,p.S111I,,Suppressor
-NCI-H2087,ACH-000841,CVCL_1524,Lung,ATM,Het,Missense,p.E848Q,,Suppressor
-NCI-H2087,ACH-000841,CVCL_1524,Lung,ATM,Het,Missense,p.L2965F,LoF,Suppressor
-NCI-H2087,ACH-000841,CVCL_1524,Lung,BRAF,Het,Missense,p.L597V,GoF,Oncogene
-NCI-H2087,ACH-000841,CVCL_1524,Lung,MYC,,Gain,GAIN,GoF,Oncogene
-NCI-H2087,ACH-000841,CVCL_1524,Lung,MYC,Het,Missense,p.E54K,,Oncogene
-NCI-H2087,ACH-000841,CVCL_1524,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
-NCI-H2087,ACH-000841,CVCL_1524,Lung,PRDM2,Hom,Missense,p.P619S,,Suppressor
-NCI-H2087,ACH-000841,CVCL_1524,Lung,RB1,Het,Splice_site,,LoF,Suppressor
-NCI-H2087,ACH-000841,CVCL_1524,Lung,TP53,Hom,Missense,p.V157F,LoF,Suppressor
-A-172,ACH-000558,CVCL_0131,CNS/Brain,ABL1,,Fusion,ABL1-CBFB,,Oncogene
-A-172,ACH-000558,CVCL_0131,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-A-172,ACH-000558,CVCL_0131,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-A-172,ACH-000558,CVCL_0131,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
-A-172,ACH-000558,CVCL_0131,CNS/Brain,RB1,Het,Missense,p.V852L,,Suppressor
-hTERT-HPNE,,CVCL_C466,Pancreas,TERT,,Transgene,,,Oncogene
-NCI-H23,ACH-000900,CVCL_1547,Lung,ATM,Hom,Missense,p.Q1919P,LoF,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,KMT2D,Het,Missense,p.G3465V,,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,KMT2D,Het,Missense,p.S4328T,,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-NCI-H23,ACH-000900,CVCL_1547,Lung,MYC,,Gain,GAIN,GoF,Oncogene
-NCI-H23,ACH-000900,CVCL_1547,Lung,PMS2,Het,Missense,p.E491K,,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,SMARCA4,Hom,Stopgain,p.1566_1567KE>N*,LoF,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,STK11,Hom,Stopgain,p.W332*,LoF,Suppressor
-NCI-H23,ACH-000900,CVCL_1547,Lung,TP53,Hom,Missense,p.M246I,LoF,Suppressor
-NCI-H1792,ACH-000496,CVCL_1495,Lung,CDKN2A,Het,Stopgain,p.W110*,LoF,Suppressor
-NCI-H1792,ACH-000496,CVCL_1495,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
-NCI-H1792,ACH-000496,CVCL_1495,Lung,MYC,,Gain,GAIN,GoF,Oncogene
-NCI-H1792,ACH-000496,CVCL_1495,Lung,SOS1,,Gain,GAIN,GoF,Oncogene
-NCI-H1792,ACH-000496,CVCL_1495,Lung,TP53,Hom,Splice_site,,LoF,Suppressor
-NCI-H2122,ACH-000311,CVCL_1531,Lung,CDKN2A,,Deletion,DEL,LoF,Suppressor
-NCI-H2122,ACH-000311,CVCL_1531,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
-NCI-H2122,ACH-000311,CVCL_1531,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
-NCI-H2122,ACH-000311,CVCL_1531,Lung,MYC,,Gain,GAIN,GoF,Oncogene
-NCI-H2122,ACH-000311,CVCL_1531,Lung,STK11,Hom,Frameshift,p.P281fs,LoF,Suppressor
-NCI-H2122,ACH-000311,CVCL_1531,Lung,TP53,Het,Missense,p.C176F,LoF,Suppressor
-NCI-H2122,ACH-000311,CVCL_1531,Lung,TP53,Het,Missense,p.Q16L,LoF,Suppressor
-NCI-H2030,ACH-000521,CVCL_1517,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
-NCI-H2030,ACH-000521,CVCL_1517,Lung,POLE,Hom,Missense,p.S780L,,Suppressor
-NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Stopgain,p.E317*,LoF,Suppressor
-NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Missense,p.E357K,,Suppressor
-NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Missense,p.M392I,,Suppressor
-NCI-H2030,ACH-000521,CVCL_1517,Lung,TP53,Hom,Missense,p.G262V,LoF,Suppressor
-LOX-IMVI,ACH-000750,CVCL_1381,Skin,ARID1A,Het,Stopgain,p.Q1212*,LoF,Suppressor
-LOX-IMVI,ACH-000750,CVCL_1381,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
-LOX-IMVI,ACH-000750,CVCL_1381,Skin,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
-LOX-IMVI,ACH-000750,CVCL_1381,Skin,NF1,Het,Stopgain,p.Q1174*,LoF,Suppressor
-LOX-IMVI,ACH-000750,CVCL_1381,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene

data/drug_metadata.csv

@@ -1,380 +0,0 @@
-drug,targets,moa-broad,moa-fine,human-approved,clinical-trials,gpt-notes-approval,canonical_smiles,pubchem_cid
-Talc,,unclear,unclear,yes,yes,Talc used in pharma and cosmetics; safety under review for some uses.,[OH-].[OH-].[O-][Si]12O[Si]3(O[Si](O1)(O[Si](O2)(O3)[O-])[O-])[O-].[Mg+2].[Mg+2].[Mg+2],165411828.0
-Bortezomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma and mantle cell lymphoma.,B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O,387447.0
-Ixazomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma treatment.,B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O,25183872.0
-Ixazomib citrate,"PSMB1, PSMB2, PSMB5",inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma treatment as part of a combination therapy.,B1(OC(=O)C(O1)(CC(=O)O)CC(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl,56844015.0
-Lactate (calcium),,unclear,unclear,yes,yes,"Used in medical settings, but not specifically approved as a standalone drug.",C.CC(C(=O)[O-])O.[Ca+2],168311648.0
-Bisoprolol (hemifumarate),ADRB1,inhibitor/antagonist,Adrenoceptor agonist,yes,yes,"Approved for hypertension, heart failure, and angina.",C.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O,168312271.0
-Fumaric acid,,inhibitor/antagonist,unclear,yes,yes,Used in psoriasis treatment as part of fumaric acid esters.,C(=CC(=O)O)C(=O)O,444972.0
-Hydroxyurea,"RRM2, RRM1",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for sickle cell anemia and certain cancers.,C(=O)(N)NO,3657.0
-L-Eflornithine (monohydrochloride),ODC1,inhibitor/antagonist,unclear,yes,yes,Used to treat sleeping sickness. Approved for human use.,C(CC(C(F)F)(C(=O)O)N)CN.Cl,16048568.0
-Cysteamine (hydrochloride),,unclear,unclear,yes,yes,FDA-approved for cystinosis treatment.,C(CS)N.Cl,9082.0
-Darinaparsin,,unclear,unclear,no,yes,Used in clinical trials for certain cancers only.,C[As](C)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N,11683005.0
-Entecavir (monohydrate),,unclear,unclear,yes,yes,Approved for treating hepatitis B infection.,C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N.O,135526609.0
-Allantoin,,unclear,unclear,yes,yes,Allantoin is approved as a skin protectant by the FDA.,C1(C(=O)NC(=O)N1)NC(=O)N,204.0
-5-Fluorouracil,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used chemotherapy drug. Approved for cancer treatment.,C1=C(C(=O)NC(=O)N1)F,3385.0
-L-Thyroxine (sodium salt pentahydrate),,unclear,unclear,yes,yes,"Approved for hypothyroidism, a form of standard thyroid hormone replacement therapy.",C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.O.O.O.O.O.[Na+],23665037.0
-Gallic acid,,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,"Used in supplements, studied for antioxidant properties.",C1=C(C=C(C(=C1O)O)O)C(=O)O,370.0
-Gallic acid (hydrate),,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Evaluated in trials but not approved as a standalone drug.,C1=C(C=C(C(=C1O)O)O)C(=O)O.O,24721416.0
-ERK5-IN-2,MAPK7,inhibitor/antagonist,Other MAPK inhibitor,no,no,Not found in clinicaltrials.gov database as of the latest available data.,C1=CC(=C(C(=C1)Br)C(=O)C2=CNC(=C2)C(=O)NC3=CN=CC=C3)F,118959080.0
-Vilanterol,ADRB2,activator/agonist,Adrenoceptor agonist,yes,yes,Combined with fluticasone furoate for asthma and COPD treatment.,C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)Cl,10184665.0
-Niclosamide (olamine),STAT3,inhibitor/antagonist,unclear,yes,yes,"Approved for parasitic infections, investigated for other uses.",C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.C(CO)N,14992.0
-Norepinephrine (hydrochloride),"ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1",activator/agonist,Adrenoceptor agonist,yes,yes,Approved for human use as a medication to treat low blood pressure.,C1=CC(=C(C=C1C(CN)O)O)O.Cl,11672905.0
-Triclosan,,inhibitor/antagonist,unclear,no,yes,Banned in soaps; used in some consumer products and healthcare settings.,C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl,5564.0
-Mitoxantrone (dihydrochloride),"TOP2A, TOP2B, PRKCA",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer and multiple sclerosis treatment.,C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl,51082.0
-Pentamidine (isethionate),PRLR,inhibitor/antagonist,unclear,yes,yes,Used to treat Pneumocystis pneumonia and African trypanosomiasis.,C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O,8813.0
-Folic acid,,unclear,unclear,yes,yes,Widely used as a dietary supplement and in fortified foods.,C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N,135398658.0
-Balsalazide (sodium hydrate),"IL6, STAT3",unclear,JAK/STAT inhibitor,yes,yes,Used for ulcerative colitis treatment in humans.,C1=CC(=CC=C1C(=O)NCCC(=O)[O-])N=NC2=CC(=C(C=C2)[O-])C(=O)O.O.O.[Na+].[Na+],92044433.0
-Resveratrol,SIRT1,unclear,unclear,no,yes,"Studies showed promising results, but no approval for therapeutic use.",C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O,445154.0
-PF-06260933,MAP4K4,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for treating pain; not approved for human use.,C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl,118701008.0
-Daidzin,ALDH2,inhibitor/antagonist,unclear,no,yes,investigated for alcoholism; not approved for treatment,C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O,107971.0
-Pemetrexed,"TYMS, DHFR, GART",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Chemotherapy drug for mesothelioma and non-small cell lung cancer.,C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O,135410875.0
-Econazole,,unclear,unclear,yes,yes,Antifungal approved for dermatological use.,C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl,3198.0
-XRK3F2,,inhibitor/antagonist,unclear,no,no,No results found on clinicaltrials.gov,C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl,135397144.0
-Arbutin,"MYC, KLF4",inhibitor/antagonist,unclear,no,yes,"Used in cosmetics, trials for skin-lightening, not approved as a drug.",C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O,440936.0
-Tucidinostat,"HDAC1, HDAC2, HDAC3, HDAC10, HDAC8, HDAC11",inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for use in China for certain cancers.,C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N,12136798.0
-Pexidartinib (hydrochloride),"CSF1R, KIT, FLT3",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for tenosynovial giant cell tumor in 2019.,C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl,73053710.0
-Sodium Salicylate,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,"Used in studies, NSAID-related research, not approved for standard human therapy.",C1=CC=C(C(=C1)C(=O)[O-])O.[Na+],16760658.0
-Salicylic acid,,inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used topically for acne and in aspirin synthesis.,C1=CC=C(C(=C1)C(=O)O)O,338.0
-Ataluren,CFTR,inhibitor/antagonist,unclear,yes,yes,For Duchenne muscular dystrophy with specific genetic mutation.,C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F,11219835.0
-4EGI-1,EIF4E,inhibitor/antagonist,Protein synthesis inhibitor,no,no,No clinical trials found for 4EGI-1 on clinicaltrials.gov.,C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-],5717952.0
-Clotrimazole,"CYP2A6, CYP51A1",inhibitor/antagonist,unclear,yes,yes,Antifungal used in topical and oral preparations.,C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4,2812.0
-Phenytoin (sodium),,inhibitor/antagonist,unclear,yes,yes,Commonly used as an anti-seizure medication.,C1=CC=C(C=C1)C2(C(=O)NC(=N2)[O-])C3=CC=CC=C3.[Na+],23679632.0
-SBI-0640756,,inhibitor/antagonist,Protein synthesis inhibitor,no,no,No record found on clinicaltrials.gov.,C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)C=CC4=CC(=CN=C4)F,121241171.0
-Oxaprozin,"PTGS1, PTGS2, NFKB1",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for arthritis treatment.,C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3,4614.0
-Baicalin,,activator/agonist,unclear,no,yes,"Used in traditional medicine, researched for various pharmacological effects.",C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O,64982.0
-Belinostat,HDAC6,inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for relapsed/refractory peripheral T-cell lymphoma.,C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO,6918638.0
-Carbamazepine,,inhibitor/antagonist,HDAC inhibitor,yes,yes,Used for epilepsy and neuropathic pain.,C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N,2554.0
-HI-TOPK-032,PBK,inhibitor/antagonist,unclear,no,no,No results found on clinicaltrials.gov.,C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N,1936439.0
-8-Hydroxyquinoline,,unclear,unclear,no,yes,"Used in some clinical trial formulations, not approved as standalone drug.",C1=CC2=C(C(=C1)O)N=CC=C2,1923.0
-Riluzole hydrochloride,,inhibitor/antagonist,unclear,yes,yes,Used in ALS treatment.,C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl,6419992.0
-Minodronic acid,"P2RX2, P2RX3",inhibitor/antagonist,unclear,no,yes,Investigated for osteoporosis; not approved in major markets.,C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O,130956.0
-GSK1059615,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, MTOR",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,"Investigated in trials, not approved for human use.",C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4,23582824.0
-Gemcitabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment like pancreatic and non-small cell lung cancer.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F,60750.0
-Cytarabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapy for leukemia and other cancers.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O,6253.0
-Cytarabine (hydrochloride),,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapy for leukemia and lymphoma.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl,6252.0
-Uridine,,unclear,unclear,no,yes,"Studied in trials; not approved as standalone drug, essential body metabolite.",C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O,6029.0
-Selinexor,XPO1,inhibitor/antagonist,unclear,yes,yes,Approved for certain cancer treatments.,C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F,71481097.0
-Furosemide,"SLC12A1, SLC12A2",inhibitor/antagonist,unclear,yes,yes,"Widely used diuretic, approved for various conditions like hypertension and edema.",C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl,3440.0
-Adenosine,"ADORA1, ADORA2A, ADORA2B, ADORA3",unclear,unclear,yes,yes,Used for certain arrhythmias; approved as a drug.,C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N,60961.0
-5-Azacytidine,DNMT1,inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,"Approved for use in specific cancers, such as myelodysplastic syndromes.",C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N,9444.0
-Clofarabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for leukemia treatment in pediatric patients.,C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N,119182.0
-Adenine,,unclear,unclear,no,no,Commonly found in supplements; not a drug approved by itself.,C1=NC2=NC=NC(=C2N1)N,190.0
-Allopurinol,XDH,inhibitor/antagonist,unclear,yes,yes,"Approved for gout treatment, reduces uric acid levels.",C1=NNC2=C1C(=O)NC=N2,135401907.0
-Trifluridine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used to treat viral infections and in cancer therapy (with tipiracil).,C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O,6256.0
-Brivudine,,unclear,unclear,yes,yes,"Approved in Europe, not widely used in the US.",C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O,446727.0
-Idoxuridine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as topical antiviral in eye infections. Approved for human use.,C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O,5905.0
-Decitabine,"DNMT1, DNMT3A, DNMT3B",inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,Approved for treatment of myelodysplastic syndromes and acute myeloid leukemia.,C1C(C(OC1N2C=NC(=NC2=O)N)CO)O,451668.0
-Lenalidomide (hemihydrate),"CRBN, IKZF1, IKZF3",inhibitor/antagonist,unclear,yes,yes,Approved for multiple myeloma and other conditions.,C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.O,46220375.0
-DT-061,,activator/agonist,unclear,no,yes,"Investigated for oncology, no approval yet for human use.",C1CC(C(C(C1)N2C3=CC=CC=C3OC4=CC=CC=C42)O)NS(=O)(=O)C5=CC=C(C=C5)OC(F)(F)F,91885558.0
-BAY1125976,"AKT1, AKT2, AKT3",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,Cancer treatment trials but not approved for human use.,C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N,70817911.0
-Larotrectinib,"NTRK1, NTRK2, NTRK3",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved specifically as a cancer treatment for tumors with NTRK gene fusions.,C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F,46188928.0
-Larotrectinib sulfate,"NTRK1, NTRK2, NTRK3",inhibitor/antagonist,Other TK inhibitor,yes,yes,Larotrectinib sulfate is approved to treat TRK fusion-positive cancers.,C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O,67330085.0
-olaparib,"PARP1, PARP2",unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for BRCA-mutated cancers.,C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F,23725625.0
-Filgotinib,"JAK1, JAK2, TYK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved in Japan and EU for rheumatoid arthritis.,C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5,49831257.0
-ULK-101,"ULK1, ULK2",inhibitor/antagonist,unclear,no,no,No clinical trial data found on clinicaltrials.gov.,C1CC1C(C(F)(F)F)NC(=O)C2=CC(=CS2)C3=C4N=CC(=CN4N=C3)C5=CC=C(C=C5)F,137628686.0
-Oxaliplatin,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for use in chemotherapy treatments.,C1CCC(C(C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2],9887053.0
-Cilostazol,PDE3A,inhibitor/antagonist,unclear,yes,yes,Used to treat intermittent claudication associated with peripheral artery disease.,C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4,2754.0
-LY2090314,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,yes,Investigated for Alzheimer's; not approved for any condition.,C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7,10029385.0
-Cobimetinib,MAP2K1,inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma in combination with vemurafenib.,C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O,16222096.0
-Asciminib,ABL1,inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for chronic myeloid leukemia (CML) treatment.,C1CN(CC1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4,72165228.0
-Capivasertib,"AKT1, AKT2, AKT3, RPS6KB1, PRKACA, ROCK2, ROCK1",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,In clinical trials for cancer. Not yet approved for human use.,C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4,25227436.0
-Penfluridol,DRD2,inhibitor/antagonist,unclear,yes,yes,Long-acting antipsychotic drug approved for human use.,C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F,33630.0
-Lonafarnib,"HRAS, KRAS, NRAS",inhibitor/antagonist,RAS inhibitor,yes,yes,Approved for progeria treatment in children.,C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N,148195.0
-Pimozide,"DRD2, DRD3",inhibitor/antagonist,unclear,yes,yes,Approved antipsychotic used mainly for Tourette's syndrome and chronic schizophrenia.,C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F,16362.0
-Clonidine (hydrochloride),"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Used for hypertension and ADHD among other conditions.,C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl,20179.0
-Brimonidine,"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Used in the form of brimonidine tartrate for glaucoma treatment.,C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br,2435.0
-AT7519,"CDK2, CDK4, CDK5, CDK6, CDK9, CDK1, CDK7, GSK3B",inhibitor/antagonist,CDK inhibitor,no,yes,Tested in trials for cancer treatments.,C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl,11338033.0
-Hydroxyfasudil,"ROCK1, ROCK2, PRKACA",inhibitor/antagonist,unclear,no,yes,"Studied for therapeutic potential; derivative of fasudil, which is approved.",C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O,3064778.0
-BI-78D3,,inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigated for Alzheimer's and inflammatory diseases, not approved for human use.",C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-],2747117.0
-ETC-206,,inhibitor/antagonist,Protein synthesis inhibitor,no,yes,"Investigational drug for cancer, not yet approved for human use.",C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3,71766360.0
-LJI308,"RPS6KA1, RPS6KA3, RPS6KA2",inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigational compound, not approved for human use as a drug.",C1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F,118704762.0
-Bimiralisib,"PIK3CA, PIK3CB, MTOR",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,Investigational PI3K/mTOR inhibitor; not approved for human use as of 2023.,C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4,58507717.0
-Bentamapimod,"MAPK8, MAPK9, MAPK10",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for ovarian cancer; not approved for human use.,C1COCCN1CC2=CC=C(C=C2)COC3=NC=CC(=N3)C(C#N)C4=NC5=CC=CC=C5S4,10195250.0
-Lipoic acid,,unclear,unclear,yes,yes,"Approved as dietary supplement, not as a drug for specific indications.",C1CSSC1CCCCC(=O)O,6112.0
-Peretinoin,"RXRA, RXRB, RXRG",unclear,Retinoic receptor agonist,no,yes,"Studied for liver cancer, not approved for human use.",CC(=CCCC(=CCCC(=CC=CC(=CC(=O)O)C)C)C)C,6437836.0
-IQ 1,,unclear,unclear,no,yes,Investigational drug; not approved for human use yet.,CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N,5823908.0
-Acetohexamide,,activator/agonist,unclear,yes,yes,"First-generation sulfonylurea, used for type 2 diabetes treatment.",CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2,1989.0
-Pentoxifylline,,inhibitor/antagonist,unclear,yes,yes,Used to improve blood flow in peripheral artery disease.,CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C,4740.0
-DTP3,,inhibitor/antagonist,unclear,no,yes,Currently being investigated in clinical trials in the UK.,CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)N,86295191.0
-Acetazolamide,,inhibitor/antagonist,unclear,yes,yes,"Used to treat glaucoma, epilepsy, and altitude sickness since 1950s.",CC(=O)NC1=NN=C(S1)S(=O)(=O)N,1986.0
-Pasireotide (acetate),"SSTR1, SSTR2, SSTR3, SSTR5",activator/agonist,unclear,yes,yes,Approved for Cushing's disease and acromegaly.,CC(=O)O.C1C(CN2C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN,72205932.0
-Chlorhexidine (diacetate),,unclear,unclear,yes,yes,Used as antiseptic and disinfectant. Approved for human use.,CC(=O)O.CC(=O)O.C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl,9562059.0
-Aspirin,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used widely for pain relief and anti-inflammatory purposes.,CC(=O)OC1=CC=CC=C1C(=O)O,2244.0
-Abiraterone acetate,CYP17A1,inhibitor/antagonist,unclear,yes,yes,Approved for prostate cancer treatment.,CC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CC=C4C5=CN=CC=C5)C)C,9821849.0
-Sivelestat (sodium tetrahydrate),ELANE,inhibitor/antagonist,unclear,no,yes,"Approved in Japan, not approved in US/EU.",CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+],23663985.0
-Atazanavir (sulfate),CYP3A4,inhibitor/antagonist,unclear,yes,yes,"Antiretroviral, approved for HIV treatment.",CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O,158550.0
-Terfenadine,HRH1,inhibitor/antagonist,unclear,no,yes,Withdrawn due to cardiac toxicity; replaced by fexofenadine.,CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O,5405.0
-Bosentan (hydrate),"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Approved for treating pulmonary arterial hypertension.,CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC.O,185462.0
-Dabrafenib,"BRAF, RAF1",inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for melanoma treatment.,CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F,44462760.0
-Ralimetinib dimesylate,"MAPKAPK2, MAPK14, MAPK11",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated as cancer treatment; not approved for human use.,CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O,11570805.0
-Saquinavir,,inhibitor/antagonist,unclear,yes,yes,Approved as part of antiretroviral therapy for HIV/AIDS.,CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)NC(=O)C4=NC5=CC=CC=C5C=C4)O,441243.0
-Pentagastrin,CCKBR,inhibitor/antagonist,unclear,yes,yes,Used mainly in diagnostic tests for gastric functions.,CC(C)(C)OC(=O)NCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N,9853654.0
-Anastrozole,CYP19A1,inhibitor/antagonist,unclear,yes,yes,Used to treat breast cancer in postmenopausal women.,CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N,2187.0
-Harringtonine,,unclear,Protein synthesis inhibitor,no,yes,"Investigated in trials mainly for cancer treatment, often used as basis for derivatives.",CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,276389.0
-Homoharringtonine,,inhibitor/antagonist,Protein synthesis inhibitor,yes,yes,"Used in leukemia treatment, also known as Omacetaxine.",CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,285033.0
-Flutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Used to treat prostate cancer as an antiandrogen.,CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F,3397.0
-Thymopentin,,unclear,unclear,no,yes,In clinical trials for immune deficiency and autoimmune diseases.,CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N,451417.0
-Aliskiren,REN,inhibitor/antagonist,unclear,yes,yes,Renin inhibitor for hypertension. Approved in the US and EU.,CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N,5493444.0
-Verapamil,"CYP3A4, ABCB1",inhibitor/antagonist,unclear,yes,yes,Used as a racemic mixture for hypertension and angina.,CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC,2520.0
-(R)-Verapamil (hydrochloride),ABCB1,inhibitor/antagonist,unclear,no,yes,"Racemic verapamil is approved, but not specifically (R)-enantiomer alone.",CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl,170014.0
-Ritonavir,,inhibitor/antagonist,unclear,yes,yes,Used in combination HIV therapies.,CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O,392622.0
-Goserelin (acetate),GNRHR,activator/agonist,unclear,yes,yes,It's approved for prostate and breast cancer treatment.,CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O,16052011.0
-Bestatin,ANPEP,inhibitor/antagonist,unclear,no,yes,Studied in trials; not approved for human therapeutic use.,CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O,72172.0
-Bestatin (hydrochloride),,inhibitor/antagonist,unclear,no,yes,Investigated in clinical trials but not approved for human use.,CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O.Cl,11957481.0
-Imiquimod (maleate),TLR7,activator/agonist,unclear,yes,yes,"Approved for skin conditions; imiquimod itself, not specifically maleate salt.",CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N.C(=CC(=O)O)C(=O)O,11595577.0
-Imiquimod (hydrochloride),TLR7,activator/agonist,unclear,yes,yes,Approved for topical treatment of skin conditions like actinic keratosis.,CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N.Cl,13982876.0
-Encorafenib,BRAF,inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for use in BRAF-mutant melanoma.,CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC,50922675.0
-AZD1390,ATM,inhibitor/antagonist,unclear,no,yes,"Investigational ATM kinase inhibitor in clinical trials, not approved for human use.",CC(C)N1C2=C(C=NC3=CC(=C(C=C32)C4=CN=C(C=C4)OCCCN5CCCCC5)F)N(C1=O)C,126689157.0
-Sapanisertib,MTOR,inhibitor/antagonist,MTOR inhibitor,no,yes,"Investigational mTOR inhibitor, not approved yet but studied for cancer treatment.",CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N,45375953.0
-Torkinib,"MTOR, PDGFRA, PRKDC, PIK3CD, PIK3CG, PIK3CA, PIK3CB, HCK, SRC, KDR, ABL1, EPHB4, EGFR",inhibitor/antagonist,MTOR inhibitor,no,yes,In clinical trials for cancer treatment but not yet approved.,CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N,135565635.0
-Belumosudil,"ROCK2, ROCK1",inhibitor/antagonist,unclear,yes,yes,Approved for chronic graft-versus-host disease in the US.,CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5,11950170.0
-Belumosudil (mesylate),"ROCK2, ROCK1",inhibitor/antagonist,unclear,yes,yes,Approved for chronic graft-versus-host disease.,CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5.CS(=O)(=O)O,146681181.0
-Esmolol (hydrochloride),ADRB1,inhibitor/antagonist,unclear,yes,yes,Used as a beta-1 blocker for acute heart issues.,CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O.Cl,104769.0
-Erdafitinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for bladder cancer treatment.,CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC,67462786.0
-Malotilate,ALOX5,inhibitor/antagonist,unclear,no,yes,"Investigated, but not approved for human use.",CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C,4006.0
-Fenofibrate,"CYP2C19, CYP2B6, CYP2C9, CYP2C8, CYP3A4, PPARA",unclear,unclear,yes,yes,Fenofibrate is approved for human use in treating hypercholesterolemia.,CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl,3339.0
-MK-8353,"MAPK3, MAPK1",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for cancer treatment in clinical trials.,CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)C4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC,58282870.0
-crizotinib,"ALK, MET, ROS1",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for NSCLC treatment.,CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N,11626560.0
-(S)-Crizotinib,NUDT1,inhibitor/antagonist,unclear,no,yes,"Racemic mixture Crizotinib is approved, not specific enantiomer.",CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N,56671814.0
-Crizotinib (hydrochloride),"ALK, MET, ROS1",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for ALK-positive NSCLC treatment.,CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl,71576688.0
-Aprepitant,TACR1,inhibitor/antagonist,unclear,yes,yes,Aprepitant is approved for preventing chemotherapy-induced nausea and vomiting.,CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F,135413536.0
-Cinacalcet,CASR,activator/agonist,unclear,yes,yes,Used to treat secondary hyperparathyroidism and parathyroid carcinoma.,CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F,156419.0
-Naproxen,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used as non-prescription NSAID in many countries.,CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O,156391.0
-Zileuton,ALOX5,inhibitor/antagonist,unclear,yes,yes,Approved for asthma treatment; 5-lipoxygenase inhibitor.,CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O,60490.0
-Voriconazole,,inhibitor/antagonist,unclear,yes,yes,Approved for treating invasive fungal infections.,CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O,71616.0
-Carbidopa (monohydrate),AHR,inhibitor/antagonist,unclear,yes,yes,Used in combination with levodopa for Parkinson's treatment.,CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN,2563.0
-Silodosin,"ADRA1A, ADRA1B, ADRA1D",inhibitor/antagonist,unclear,yes,yes,Approved for benign prostatic hyperplasia treatment.,CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F,5312125.0
-Darolutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Approved for treating non-metastatic castration-resistant prostate cancer.,CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=NNC(=C3)C(C)O,67171867.0
-Benproperine (phosphate),ARPC2,inhibitor/antagonist,unclear,yes,yes,Studied as a cough suppressant; not widely approved.,CC(COC1=CC=CC=C1CC2=CC=CC=C2)N3CCCCC3.OP(=O)(O)O,167811.0
-Bicalutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Approved as antiandrogen for prostate cancer treatment.,CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O,2375.0
-Captopril,ACE,inhibitor/antagonist,unclear,yes,yes,First ACE inhibitor approved for hypertension and heart failure.,CC(CS)C(=O)N1CCCC1C(=O)O,44093.0
-Tirabrutinib,BTK,inhibitor/antagonist,Other TK inhibitor,no,yes,"In clinical trials, not approved for human use yet.",CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N,54755438.0
-Tirabrutinib (hydrochloride),BTK,inhibitor/antagonist,Other TK inhibitor,no,yes,Not approved in US/EU; used investigationally in some regions.,CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl,71571562.0
-Mifepristone,"NR3C1, PGR",inhibitor/antagonist,unclear,yes,yes,Approved for medical abortion and Cushing's syndrome treatment.,CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O,55245.0
-Fostamatinib (disodium hexahydrate),"SYK, FLT3, LYN, LCK",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for treatment of chronic immune thrombocytopenia in adults.,CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+],146673142.0
-Temuterkib,,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Temuterkib is in clinical trials for cancer treatment.,CC1(C2=C(C=C(S2)C3=NC(=NC=C3)NC4=CC=NN4C)C(=O)N1CCN5CCOCC5)C,121408882.0
-Tetracycline (hydrochloride),,unclear,unclear,yes,yes,Approved antibiotic often used as tetracycline hydrochloride.,CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl,54704426.0
-Glycyrrhizic acid,,inhibitor/antagonist,unclear,no,yes,"Tested for therapeutic effects, not approved for human use.",CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C,14982.0
-Diammonium Glycyrrhizinate,,unclear,unclear,no,yes,Used in trials for hepatitis. Not approved for general human use.,CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N.N,656656.0
-venetoclax,BCL2,inhibitor/antagonist,unclear,yes,yes,Approved for chronic lymphocytic leukemia and other cancers.,CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C,49846579.0
-Delamanid,,inhibitor/antagonist,unclear,yes,yes,Approved for MDR-TB treatment.,CC1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F,6480466.0
-Dexmedetomidine,"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Approved as sedative and analgesic.,CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C,5311068.0
-Ranolazine,,inhibitor/antagonist,unclear,yes,yes,Approved for treating chronic angina.,CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O,56959.0
-Lopinavir,,inhibitor/antagonist,unclear,yes,yes,Combined with ritonavir for HIV treatment. Approved for human use.,CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O,92727.0
-Valdecoxib,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Withdrawn due to safety concerns related to cardiovascular risks.,CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N,119607.0
-Cloxacillin (sodium),,inhibitor/antagonist,unclear,yes,yes,Approved as a penicillinase-resistant antibiotic for human use.,CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+],23675320.0
-Elagolix sodium,GNRHR,inhibitor/antagonist,unclear,yes,yes,Approved for endometriosis pain in women.,CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)C(F)(F)F)CC(C3=CC=CC=C3)NCCCC(=O)[O-])C4=C(C(=CC=C4)OC)F.[Na+],24785956.0
-palbociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use as a cancer treatment.,CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C,5330286.0
-Retinoic acid,"RARB, RARG, RARA, PPARD",activator/agonist,Retinoic receptor agonist,yes,yes,Approved for acne and leukemia treatment.,CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C,444795.0
-PH-797804,MAPK14,inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigated as an anti-inflammatory agent, not approved for human use.",CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C,22049997.0
-Ponatinib,"ABL1, PDGFRA, KDR, FGFR1, SRC, KIT",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for treatment of certain types of leukemia.,CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5,24826799.0
-Radotinib,ABL1,inhibitor/antagonist,Other TK inhibitor,no,yes,"Tested for chronic myeloid leukemia, not approved in major markets.",CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=NC=CN=C5,16063245.0
-NVP-BHG712,EPHB4,inhibitor/antagonist,unclear,no,yes,Investigated as angiogenesis inhibitor; not approved for human use.,CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=C4C=NN(C4=NC(=N3)C5=CN=CC=C5)C,16747388.0
-Canagliflozin,SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for type 2 diabetes treatment.,CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F,24812758.0
-MK-3903,PRKAA1,activator/agonist,unclear,no,yes,"Investigated for NASH, not yet approved for human use.",CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C(=O)O,45256689.0
-EX229,PRKAA1,activator/agonist,unclear,no,no,No clinical trial information found on clinicaltrials.gov.,CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O,45256693.0
-Flumatinib (mesylate),ABL1,inhibitor/antagonist,Other TK inhibitor,no,yes,Used in trials for chronic myeloid leukemia.,CC1=C(C=C(C=N1)NC(=O)C2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O,46910592.0
-Tucatinib,ERBB2,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use in advanced HER2-positive breast cancer.,CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5,51039094.0
-Trimetrexate,DHFR,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used with leucovorin for treating certain types of pneumonia.,CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC,5583.0
-APTO-253,"MYC, KLF4",unclear,unclear,no,yes,"Investigated for cancer, but development discontinued.",CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6,11960271.0
-Vitamin K4,,unclear,unclear,no,yes,Investigated in a clinical trial in Egypt.,CC1=C(C2=CC=CC=C2C(=C1)OC(=O)C)OC(=O)C,11310.0
-Panobinostat,"HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, HDAC11",inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for multiple myeloma treatment.,CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO,6918837.0
-Rimonabant,CNR1,inhibitor/antagonist,unclear,no,yes,Withdrawn due to psychiatric side effects.,CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl,104850.0
-Rimonabant (Hydrochloride),CNR1,inhibitor/antagonist,unclear,no,yes,"Withdrawn due to psychiatric side effects, once used as anti-obesity drug.",CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl.Cl,104849.0
-Ligustrazine,,unclear,unclear,no,yes,"Mainly used in traditional Chinese medicine, limited human trials exist.",CC1=C(N=C(C(=N1)C)C)C,14296.0
-Sulfisoxazole,"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Discontinued in U.S.; previously used for bacterial infections.,CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N,5344.0
-Alpelisib,PIK3CA,inhibitor/antagonist,PI3K/AKT inhibitor,yes,yes,Approved for HR+/HER2- advanced breast cancer in combination with fulvestrant.,CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F,56649450.0
-Trametinib,"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma treatment.,CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5,11707110.0
-Nevirapine,,inhibitor/antagonist,unclear,yes,yes,Antiretroviral for HIV treatment approved for human use.,CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4,4463.0
-Tomivosertib,,inhibitor/antagonist,Protein synthesis inhibitor,no,yes,In clinical trials for cancer; not FDA approved for human use yet.,CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3,118598754.0
-Paclitaxel,,unclear,Microtubule inhibitor,yes,yes,Chemotherapy drug approved for cancer treatment.,CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C,36314.0
-Docetaxel,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,"Approved anticancer drug, often used in chemotherapy treatments.",CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O,148124.0
-Docetaxel (Trihydrate),"TUBB1, TUBB3, TUBB4B, TUBB4A, TUBB2A, TUBB2B",unclear,Microtubule inhibitor,yes,yes,"Approved cancer treatment, commonly used in chemotherapy.",CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O.O.O.O,148123.0
-Roxadustat,,inhibitor/antagonist,unclear,yes,yes,"Approved for anemia treatment in some countries, e.g., China, Japan.",CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3,11256664.0
-Thymol,TRPA1,activator/agonist,unclear,no,yes,Used in clinical trials as antiseptic and antifungal.,CC1=CC(=C(C=C1)C(C)C)O,6989.0
-Gemfibrozil,"PPARA, CYP2C9, CYP2C19, CYP2C8, CYP1A2",unclear,unclear,yes,yes,Approved for dyslipidemia treatment.,CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O,3463.0
-Vortioxetine,"SLC6A4, HTR3A, HTR7",unclear,unclear,yes,yes,Approved for major depressive disorder.,CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C,9966051.0
-OTS514,MAP3K8,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigational drug in preclinical and early phase clinical trials.,CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN)O,67448836.0
-Pralsetinib,RET,inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for RET fusion-positive cancers.,CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC,129073603.0
-Menadione,,unclear,unclear,no,yes,"Used in trials; a vitamin K analog, not fully approved for human use.",CC1=CC(=O)C2=CC=CC=C2C1=O,4055.0
-Ciclopirox,,unclear,unclear,yes,yes,"Approved for antifungal use, primarily in nail and skin treatments.",CC1=CC(=O)N(C(=C1)C2CCCCC2)O,2749.0
-Methylthiouracil,,unclear,unclear,no,yes,"Used in research, not approved for human therapeutic use.",CC1=CC(=O)NC(=S)N1,667493.0
-Tolcapone,COMT,inhibitor/antagonist,unclear,yes,yes,"Used in Parkinson's treatment, subject to liver monitoring.",CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-],4659569.0
-Tolmetin,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for pain and inflammation.,CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O,5509.0
-Celecoxib,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used for arthritis pain and inflammation; approved NSAID.,CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F,2662.0
-S-Adenosyl-L-methionine (disulfate tosylate),,unclear,unclear,yes,yes,Used as dietary supplement; approved in some countries for depression treatment.,CC1=CC=C(C=C1)S(=O)(=O)O.C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O.OS(=O)(=O)O.OS(=O)(=O)[O-],9875462.0
-Lapatinib ditosylate,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for use in breast cancer treatment.,CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O,11557040.0
-LY-2584702 (tosylate salt),RPS6KB1,inhibitor/antagonist,MTOR inhibitor,no,yes,Investigated in clinical trials for cancer treatment. Not approved for human use.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F,46205871.0
-Edoxaban (tosylate monohydrate),F10,inhibitor/antagonist,unclear,yes,yes,Approved as an anticoagulant for preventing stroke and blood clots.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O,25022378.0
-Lumateperone (tosylate),"HTR2A, DRD2",unclear,unclear,yes,yes,Approved for schizophrenia; marketed as Caplyta.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN2C3CCN(CC3C4=C2C1=CC=C4)CCCC(=O)C5=CC=C(C=C5)F,44241743.0
-Mozavaptan,AVPR2,inhibitor/antagonist,unclear,no,yes,In trials for conditions like hyponatremia but not approved for use.,CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C,119369.0
-Bexarotene,"RXRA, RXRB, RXRG",activator/agonist,Retinoic receptor agonist,yes,yes,Approved for treating cutaneous T-cell lymphoma.,CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C,82146.0
-Sulfatinib,"FLT1, KDR, FLT4, FGFR1, CSF1R",inhibitor/antagonist,Multi-TK inhibitor,no,yes,"Investigated in trials for neuroendocrine tumors, not yet approved for use.",CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C,52920501.0
-Olanzapine,"HTR2A, HTR2C, DRD2, DRD4, ADRA1A, ADRA1B, ADRA1D, HTR6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5",inhibitor/antagonist,unclear,yes,yes,Olanzapine is used in treatment of schizophrenia and bipolar disorder.,CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C,135398745.0
-AZD-7648,PRKDC,inhibitor/antagonist,DNA synthesis/repair inhibitor,no,yes,"Inhibitor studied for DNA repair, not yet approved for human use.",CC1=CC2=NC=NN2C=C1NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCOCC5,135151360.0
-Megestrol,,unclear,unclear,yes,yes,Used for appetite loss and weight gain in cancer/AIDS patients.,CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C,19090.0
-Omeprazole (sodium),,inhibitor/antagonist,unclear,yes,yes,Approved in salt form as acid reflux treatment.,CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+],12108541.0
-Omeprazole,,inhibitor/antagonist,unclear,yes,yes,Used as part of racemic mixture for acid-related conditions.,CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC,4594.0
-Fedratinib (hydrochloride hydrate),"JAK2, FLT3, RET",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for treatment of myelofibrosis.,CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4.O.Cl.Cl,67517580.0
-Meloxicam,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Meloxicam is an approved NSAID for pain and inflammation.,CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O,54677470.0
-Pyridoxine,,unclear,unclear,yes,yes,Vitamin B6; essential nutrient approved for various health conditions.,CC1=NC=C(C(=C1O)CO)CO,1054.0
-Pyridoxine (hydrochloride),,unclear,unclear,yes,yes,"Vitamin B6, approved for various medical conditions.",CC1=NC=C(C(=C1O)CO)CO.Cl,6019.0
-Ornidazole,,unclear,unclear,yes,yes,"Used for bacterial and protozoal infections, common in some countries.",CC1=NC=C(N1CC(CCl)O)[N+](=O)[O-],28061.0
-Raltitrexed,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment as thymidylate synthase inhibitor.,CC1=NC2=C(C=C(C=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1,135400182.0
-BI-3406,"KRAS, SOS1",inhibitor/antagonist,RAS inhibitor,no,yes,"Investigational compound, clinical trials for KRAS-driven cancers.",CC1=NC2=CC(=C(C=C2C(=N1)NC(C)C3=CC(=CC(=C3)N)C(F)(F)F)OC4CCOC4)OC,138911318.0
-Triamcinolone,NR3C1,unclear,Glucocorticoid receptor agonist,yes,yes,Approved corticosteroid for various inflammatory and allergic conditions.,CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O,31307.0
-Drospirenone,,unclear,unclear,yes,yes,"Found in birth control, often combined with ethinyl estradiol.",CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C,68873.0
-Eplerenone,NR3C2,inhibitor/antagonist,unclear,yes,yes,Used to treat heart failure and hypertension.,CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC,443872.0
-Quinestrol,,unclear,unclear,yes,yes,Estrogen approved for use in menopausal therapy and contraceptives.,CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5,9046.0
-Estrone sulfate (potassium),,unclear,unclear,no,yes,Estrone sulfate used in hormone therapy; potassium salt not specifically approved.,CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[K+],23674502.0
-Finasteride,SRD5A2,inhibitor/antagonist,unclear,yes,yes,Used for benign prostatic hyperplasia and male pattern baldness.,CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C,57363.0
-Fulvestrant,ESR1,inhibitor/antagonist,unclear,yes,yes,Estrogen receptor antagonist used for hormone receptor-positive breast cancer.,CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F,104741.0
-Monocrotaline,"SLC22A1, SLC22A2",inhibitor/antagonist,unclear,no,no,"Toxic pyrrolizidine alkaloid, not approved for human use.",CC1C(=O)OC2CCN3C2C(=CC3)COC(=O)C(C1(C)O)(C)O,9415.0
-Ouabain (Octahydrate),,unclear,unclear,no,yes,Investigated for heart failure but not approved for human use.,CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O,6364534.0
-Rutin (trihydrate),,unclear,unclear,no,no,Commonly used in supplements; lacks regulatory approval as a drug.,CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O.O.O.O,16218542.0
-Hesperidin,,unclear,unclear,no,yes,"Studied for various health benefits, but not approved as a drug.",CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O,10621.0
-Digitoxin,,unclear,unclear,no,yes,"Clinical trials for certain conditions, but not FDA approved for human use.",CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O,441207.0
-Doxorubicin (hydrochloride),"TOP2A, TOP2B, TOP1",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Commonly used chemotherapy drug for several cancers.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl,443939.0
-Epirubicin (hydrochloride),TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapies as single agent or in combination treatments.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl,65348.0
-Idarubicin (hydrochloride),TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in acute myeloid leukemia treatment.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl,636362.0
-Plicamycin,"SP1, GSTM2",inhibitor/antagonist,unclear,yes,yes,Plicamycin is used to treat testicular cancer and hypercalcemia.,CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O,163659.0
-Rifaximin,,unclear,unclear,yes,yes,Approved for treatment of IBS and hepatic encephalopathy.,CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C,6436173.0
-Doxycycline (monohydrate),"MMP7, MMP8, MMP9, MMP13, MMP14",inhibitor/antagonist,unclear,yes,yes,Approved antibiotic for bacterial infections.,CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O,54684461.0
-Fusidic acid,,inhibitor/antagonist,unclear,yes,yes,Used topically and orally for bacterial infections.,CC1C2CCC3(C(C2(CCC1O)C)C(CC4C3(CC(C4=C(CCC=C(C)C)C(=O)O)OC(=O)C)C)O)C,3000226.0
-Ipatasertib,"AKT1, AKT2, AKT3",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,"Investigational cancer drug, not approved for human use.",CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O,24788740.0
-Medroxyprogesterone acetate,PGR,unclear,unclear,yes,yes,Approved as a contraceptive and for hormone therapy.,CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C,6279.0
-Methylprednisolone succinate,NR3C1,unclear,Glucocorticoid receptor agonist,yes,yes,Corticosteroid; approved for reducing inflammation in various conditions.,CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O,16923.0
-Dexamethasone,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,Commonly used glucocorticoid for inflammation and immune response regulation.,CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C,5743.0
-Dihydroartemisinin,,unclear,unclear,yes,yes,"Active metabolite of artemisinin, approved for malaria treatment.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C,3000518.0
-Artesunate,,inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,"Used for severe malaria, often partnered with other antimalarial drugs.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C,6917864.0
-Artemether,,unclear,unclear,yes,yes,Artemether is used in combination with lumefantrine to treat malaria.,CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C,68911.0
-Rapamycin,"MTOR, FKBP1A",inhibitor/antagonist,MTOR inhibitor,yes,yes,Approved mainly for organ transplantation and cancer treatment.,CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC,5284616.0
-Temsirolimus,MTOR,inhibitor/antagonist,MTOR inhibitor,yes,yes,Approved for treating renal cell carcinoma.,CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC,6918289.0
-Everolimus,"MTOR, FKBP1A",inhibitor/antagonist,MTOR inhibitor,yes,yes,"Approved for certain types of cancer, organ transplantation, and tuberous sclerosis.",CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC,6442177.0
-Tofacitinib,"JAK1, JAK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for rheumatoid arthritis and other conditions.,CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N,9926791.0
-Tofacitinib (citrate),"JAK1, JAK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for rheumatoid arthritis and other conditions.,CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O,10174505.0
-Sonidegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for basal cell carcinoma treatment.,CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F,24775005.0
-AZD-8055,MTOR,inhibitor/antagonist,MTOR inhibitor,no,yes,Investigational drug; explored in trials mainly for cancer treatment.,CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C,25262965.0
-Elimusertib hydrochloride,ATR,inhibitor/antagonist,unclear,no,yes,Tested in trials for cancer but not approved for human use.,CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C,118869362.0
-Clobetasol propionate,"CYP3A5,CYP3A4",inhibitor/antagonist,unclear,yes,yes,It's a potent corticosteroid for skin conditions.,CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl,32798.0
-Betamethasone dipropionate,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,A corticosteroid approved and used in topical formulations for inflammation.,CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)OC(=O)CC,21800.0
-Posaconazole,,unclear,unclear,yes,yes,Broad-spectrum antifungal approved for human use.,CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F,468595.0
-Pravastatin (sodium),HMGCR,inhibitor/antagonist,unclear,yes,yes,Approved as a cholesterol-lowering agent.,CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O.[Na+],16759173.0
-Ivermectin,,unclear,unclear,yes,yes,Approved for infections in humans and animals.,CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C,6321424.0
-Topotecan (hydrochloride),TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,"Approved for treating ovarian, small cell lung, and cervical cancer.",CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl,60699.0
-Vinblastine (sulfate),,inhibitor/antagonist,Microtubule inhibitor,yes,yes,"Used in cancer treatment, notably Hodgkin's lymphoma.",CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,5388983.0
-vincristine,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,Used in chemotherapy for various cancers.,CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,249332.0
-Indacaterol (maleate),ADRB2,activator/agonist,Adrenoceptor agonist,yes,yes,Approved for COPD as a long-acting bronchodilator.,CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O,9827599.0
-Pimitespib,"HSP90AA1, HSP90AB1",inhibitor/antagonist,unclear,no,yes,Investigated in trials for cancer; not approved for human use yet.,CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C,67501411.0
-Irinotecan,TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,"Used in cancer treatment, especially for colorectal cancer.",CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7,60838.0
-Irinotecan (hydrochloride),TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment as a topoisomerase inhibitor.,CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl,74990.0
-Dinaciclib,"CDK1, CDK2, CDK5, CDK9",inhibitor/antagonist,CDK inhibitor,no,yes,Investigated in trials; not yet approved for human use.,CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO,46926350.0
-Pioglitazone,PPARG,activator/agonist,unclear,yes,yes,Approved for type 2 diabetes treatment.,CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3,4829.0
-Volasertib,"PLK1, PLK2, PLK3",inhibitor/antagonist,unclear,no,yes,"Investigated for cancer treatment, not approved for human use.",CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C,10461508.0
-Cyclosporin A,"PPP3CA, PPP3CB, PPP3CC",inhibitor/antagonist,unclear,yes,yes,Immunosuppressant approved for organ transplant patients.,CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C,5284373.0
-Erythromycin,,inhibitor/antagonist,unclear,yes,yes,Antibiotic used to treat infections; approved for human use.,CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O,12560.0
-Azithromycin (hydrate),,unclear,unclear,yes,yes,Approved as an antibiotic for bacterial infections.,CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O,3033819.0
-Perindopril (erbumine),"STAT3, ACE",inhibitor/antagonist,unclear,yes,yes,Approved ACE inhibitor for hypertension and heart failure.,CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N,441313.0
-Sildenafil,PDE5A,inhibitor/antagonist,unclear,yes,yes,Approved for erectile dysfunction and pulmonary arterial hypertension.,CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C,135398744.0
-Budesonide,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,"Used for asthma, Crohn's disease, ulcerative colitis.",CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C,5281004.0
-Hexylresorcinol,,inhibitor/antagonist,unclear,yes,yes,Used in throat lozenges and skin creams for antiseptic purposes.,CCCCCCC1=C(C=C(C=C1)O)O,3610.0
-Oleic acid,,activator/agonist,unclear,yes,yes,"Used in food, cosmetics, and as an excipient in pharmaceuticals.",CCCCCCCCC=CCCCCCCCC(=O)O,445639.0
-Fingolimod (hydrochloride),PAK1,unclear,unclear,yes,yes,Approved for multiple sclerosis treatment.,CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl,107969.0
-Daptomycin,,unclear,unclear,yes,yes,Approved as an antibiotic for skin infections.,CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C,21585658.0
-Orlistat,,inhibitor/antagonist,unclear,yes,yes,Used to treat obesity by preventing fat absorption.,CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O,3034010.0
-Levobupivacaine (hydrochloride),SCN5A,inhibitor/antagonist,unclear,yes,yes,Approved as an enantiomer of bupivacaine for anesthetic use.,CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl,117965.0
-Proglumide,"CCKBR, CCKAR",inhibitor/antagonist,unclear,no,yes,"Proglumide investigated for gastrointestinal use, not widely approved for humans.",CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1,4922.0
-Ropivacaine (hydrochloride monohydrate),,inhibitor/antagonist,unclear,yes,yes,A local anesthetic used in surgeries and pain management.,CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl,6918111.0
-Macitentan,"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Approved for pulmonary arterial hypertension treatment.,CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br,16004692.0
-Vemurafenib,BRAF,inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for treating BRAF V600E mutation-positive melanoma.,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F,42611257.0
-Lidocaine (hydrochloride),"MAP2K1, MAPK1, NFKB1",unclear,unclear,yes,yes,Lidocaine hydrochloride is approved as a local anesthetic.,CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl,6314.0
-Sunitinib,"KDR, PDGFRB",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved anticancer drug used for renal cell carcinoma and gastrointestinal stromal tumors.,CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C,5329102.0
-Procainamide (hydrochloride),DNMT1,inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,Used for arrhythmias; often as its hydrochloride salt form.,CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl,66068.0
-Lucanthone,,inhibitor/antagonist,unclear,no,yes,"Investigated for cancer treatment, not approved for human use.",CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O,10180.0
-RMC-6236,KRAS,inhibitor/antagonist,RAS inhibitor,no,yes,"Investigated as a potential cancer treatment, but not approved for human use.",CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C)C(C)OC)(C)C)NC(=O)C8CC8C,164726578.0
-Pemigatinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for treating cholangiocarcinoma.,CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5,86705695.0
-Infigratinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Used for bile duct cancer treatment.,CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl,53235510.0
-NG25,"MAP4K2, MAP3K7, LYN, ABL1, ABL2, FER, SRC, EPHA2, EPHB2, EPHB4, ZAK, ZKSCAN1, RAF1",inhibitor/antagonist,Other MAPK inhibitor,no,yes,"NG25 is in preclinical stages, not approved for humans.",CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F,53340664.0
-Abemaciclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,"FDA approved for HR-positive, HER2-negative breast cancer.",CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F,46220502.0
-Bimatoprost,,unclear,unclear,yes,yes,Approved for treating glaucoma and cosmetic lash applications.,CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O,5311027.0
-Dorzolamide (hydrochloride),CA2,inhibitor/antagonist,unclear,yes,yes,Approved for glaucoma treatment.,CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl,6918132.0
-Tazarotene,"RARA, RARB, RARG",activator/agonist,Retinoic receptor agonist,yes,yes,Topical retinoid approved for psoriasis and acne treatment.,CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C,5381.0
-Neratinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for breast cancer treatment.,CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C,9915743.0
-Neratinib (maleate),"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for HER2-positive breast cancer treatment.,CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C.C(=CC(=O)O)C(=O)O,67307512.0
-Dapagliflozin,SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for diabetes treatment.,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl,9887712.0
-"Dapagliflozin ((2S)-1,2-propanediol, hydrate)",SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved SGLT2 inhibitor for type 2 diabetes and heart failure.,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CC(CO)O.O,24906252.0
-Auranofin,"TXNRD1, TXNRD2",inhibitor/antagonist,unclear,yes,yes,Approved for rheumatoid arthritis treatment since 1985.,CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+],24199313.0
-TAK-901,AURKB,inhibitor/antagonist,unclear,no,yes,Investigational cancer drug; not approved for human use yet.,CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C,16124208.0
-Loperamide (hydrochloride),,unclear,unclear,yes,yes,"Approved for diarrhea treatment, limited CNS penetration due to P-gp substrate.",CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl,71420.0
-Ribociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use in combination with letrozole for breast cancer.,CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5,44631912.0
-Altretamine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as a chemotherapy drug for ovarian cancer.,CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C,2123.0
-Demeclocycline,,inhibitor/antagonist,unclear,yes,yes,"Used off-label for SIADH, primarily an antibiotic.",CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O,54680690.0
-Afatinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,"Approved for treatment of certain cancers, such as non-small cell lung cancer.",CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4,10184653.0
-Relugolix,GNRHR,inhibitor/antagonist,unclear,yes,yes,Approved for prostate cancer and uterine fibroids treatment.,CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC,10348973.0
-Citalopram (hydrobromide),SLC6A4,inhibitor/antagonist,unclear,yes,yes,Approved antidepressant; selective serotonin reuptake inhibitor (SSRI).,CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br,77995.0
-Almonertinib (hydrochloride),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved in China for non-small cell lung cancer.,CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.Cl,137319707.0
-Almonertinib (mesylate),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved in China for NSCLC treatment.,CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O,162368359.0
-Diphenhydramine,HRH1,inhibitor/antagonist,unclear,yes,yes,"Approved antihistamine, used for allergies and as a sleep aid.",CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2,3100.0
-ML264,KLF5,inhibitor/antagonist,unclear,no,no,No clinical trials found on clinicaltrials.gov.,CN(C1CCS(=O)(=O)CC1)C(=O)CNC(=O)C=CC2=CC(=CC=C2)Cl,51003603.0
-Methotrexate,DHFR,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used for cancer and autoimmune diseases treatments.,CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O,126941.0
-Ivabradine (hydrochloride),HCN4,inhibitor/antagonist,unclear,yes,yes,"Approved for human use, primarily for heart failure and angina management.",CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl,3045381.0
-Rosiglitazone,"PPARG, TRPC5, TRPM3",unclear,unclear,yes,yes,Approved for diabetes; risk of heart failure in some patients.,CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3,77999.0
-Piroxicam,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for arthritis and pain relief.,CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3,54676228.0
-c-Kit-IN-1,"KIT, MET, KDR, PDGFRA, PDGFRB",inhibitor/antagonist,Multi-TK inhibitor,no,no,Experimental compound with no clinical trials reported.,CN1C=C(C=N1)C2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)F,46208890.0
-CP21R7,"GSK3B, PRKCA",inhibitor/antagonist,GSK3 inhibitor,no,yes,Investigational drug in research for neurodegenerative diseases.,CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CC(=CC=C4)N,5327711.0
-9-ING-41,GSK3B,inhibitor/antagonist,GSK3 inhibitor,no,yes,"Investigational drug, not approved for human use yet.",CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F,44582816.0
-Binimetinib,"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,no,yes,"Investigated for cancer, not approved for human use.",CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO,10288191.0
-TAK-733,MAP2K1,inhibitor/antagonist,MEK inhibitor,no,yes,Investigated as anti-cancer MEK inhibitor; not approved for human use.,CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O,24963252.0
-Bendamustine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in leukemia and lymphoma treatment.,CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O,65628.0
-Benztropine (mesylate),,inhibitor/antagonist,unclear,yes,yes,Used for Parkinson's disease and drug-induced extrapyramidal symptoms.,CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)O,238053.0
-Tadalafil,PDE5A,inhibitor/antagonist,unclear,yes,yes,Used for erectile dysfunction and pulmonary arterial hypertension.,CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36,110635.0
-Vandetanib,"EGFR, KDR",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for use in medullary thyroid cancer.,CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC,3081361.0
-Glasdegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Glasdegib is approved for acute myeloid leukemia.,CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N,25166913.0
-Isocorydine,,unclear,unclear,no,no,No clinical trials found on clinicaltrials.gov,CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)OC)OC,10143.0
-Berbamine,CACNA1C,inhibitor/antagonist,unclear,no,no,"Studied for cancer treatment, but not approved for human use yet.",CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC,275182.0
-Berbamine (dihydrochloride),,inhibitor/antagonist,unclear,no,no,No clinical trial data found on clinicaltrials.gov.,CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl,16217067.0
-Cepharanthine,"CYP3A4, CYP2E1, CYP2C9",inhibitor/antagonist,unclear,no,yes,Studied for cancer and viral diseases; not approved for human use yet.,CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3,10206.0
-Sinomenine,OPRM1,unclear,unclear,no,yes,Used in trials for pain and arthritis.,CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC,5459308.0
-Adagrasib,KRAS,inhibitor/antagonist,RAS inhibitor,yes,yes,Approved for treating KRAS G12C-mutated non-small cell lung cancer.,CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(C6)CC#N)C(=O)C(=C)F,138611145.0
-LB-100,"PPP2CA, PPP2CB",inhibitor/antagonist,unclear,no,yes,LB-100 is in clinical trials for cancer treatment.,CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3,3578572.0
-Entrectinib,"NTRK1, NTRK2, NTRK3, ROS1, ALK",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for use in cancers with NTRK gene fusions.,CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6,25141092.0
-AZD2858,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,no,Investigated in rodent models.,CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N,10138980.0
-Capmatinib,MET,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for NSCLC treatment by FDA in May 2020.,CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F,25145656.0
-Apalutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Used for non-metastatic castration-resistant prostate cancer.,CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F,24872560.0
-Regorafenib,"BRAF, FLT1, FLT4, KDR, KIT, PDGFRB, RAF1, RET, TEK",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,"Used for metastatic colorectal cancer, GIST, HCC.",CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F,11167602.0
-Phenylephrine (hydrochloride),"ADRA1A, ADRA1B, ADRA1D",activator/agonist,Adrenoceptor agonist,yes,yes,Widely used as a decongestant and in eye drops.,CNCC(C1=CC(=CC=C1)O)O.Cl,5284443.0
-Rucaparib (phosphate),"PARP1, PARP2, PARP3",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved as a cancer therapy PARP inhibitor.,CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O,9931953.0
-Clopidogrel,P2RY12,inhibitor/antagonist,unclear,yes,yes,"Antiplatelet drug approved for preventing stroke, heart attack in high-risk patients.",COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3,60606.0
-Dimethyl fumarate,NFE2L2,activator/agonist,unclear,yes,yes,Approved for multiple sclerosis treatment.,COC(=O)C=CC(=O)OC,637568.0
-Methyl aminolevulinate (hydrochloride),,unclear,unclear,yes,yes,Used in photodynamic therapy for actinic keratosis.,COC(=O)CCC(=O)CN.Cl,157921.0
-Mebendazole,"TUBA1A, TUBA1B, TUBA1C, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB4B, TUBB6",inhibitor/antagonist,Microtubule inhibitor,yes,yes,Approved for treating parasitic worm infestations.,COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3,4030.0
-Tranilast,"PLA2G2A, EGR1",inhibitor/antagonist,unclear,yes,yes,Approved for asthma and allergic disorders in some countries.,COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC,5282230.0
-Gefitinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for non-small cell lung cancer.,COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4,123631.0
-Simotinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,no,yes,"Investigated in trials, but not approved for human use.",COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCN4CC5(CC5)C6(C4)OCCO6,16735117.0
-Bergenin,,unclear,unclear,no,yes,Investigated for anti-inflammatory and antiulcer effects in clinical trials.,COC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O,66065.0
-Ferulic acid,"FGFR1, FGFR2",inhibitor/antagonist,Other TK inhibitor,no,yes,Used in skincare; not an FDA-approved drug.,COC1=C(C=CC(=C1)C=CC(=O)O)O,445858.0
-Amsacrine,TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in the treatment of acute leukemias.,COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42,2179.0
-Palmatine (chloride),"IDO1, WNV NS2B-NS3",inhibitor/antagonist,unclear,no,yes,Used in some traditional medicine; lacks formal approval for human use.,COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-],73442.0
-Berberine (chloride hydrate),,unclear,unclear,no,yes,"Used in trials for metabolic/heart diseases, not FDA-approved.",COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.O.[Cl-],155074.0
-Futibatinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Used for cholangiocarcinoma; FDA approved.,COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)C4CCN(C4)C(=O)C=C)OC,71621331.0
-Tubulin inhibitor 6,,inhibitor/antagonist,Microtubule inhibitor,no,no,No available data on human use or clinical trials.,COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl,2359994.0
-Anethole trithione,,unclear,unclear,no,yes,Investigated for dry mouth in clinical trials.,COC1=CC=C(C=C1)C2=CC(=S)SS2,2194.0
-Cabozantinib (S-malate),"MET, KDR, AXL",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for medullary thyroid cancer and renal cell carcinoma.,COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O,25102846.0
-Fluvoxamine,SLC6A4,unclear,unclear,yes,yes,SSRI approved for treating OCD and depression.,COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F,5324346.0
-Fluvoxamine (maleate),,inhibitor/antagonist,unclear,yes,yes,Approved for treating OCD and depression-related disorders in humans.,COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F.C(=CC(=O)O)C(=O)O,9560989.0
-Erlotinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use for non-small cell lung cancer.,COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC,176870.0
-Belzutifan,EPAS1,inhibitor/antagonist,unclear,yes,yes,Approved for treating certain cancer types.,CS(=O)(=O)C1=C2C(C(C(C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O,117947097.0
-Vismodegib,"SMO, ABCB1, ABCG2",inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for treating basal cell carcinoma.,CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl,24776445.0
-Nimesulide,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Withdrawn in some countries due to safety concerns; not FDA-approved.,CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2,4495.0
-Nafamostat (mesylate),,inhibitor/antagonist,unclear,yes,yes,"Approved in some countries, often used as anticoagulant.",CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N,5311180.0
-Busulfan,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in bone marrow transplantation.,CS(=O)(=O)OCCCCOS(=O)(=O)C,2478.0
-18β-Glycyrrhetinic acid,,unclear,unclear,no,yes,"Used in cosmetics, derived from licorice root, no approval for human drugs.",C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O,10114.0
-Trametinib (DMSO_TF solvate),"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,yes,yes,"Approved for use in cancer treatment (e.g., melanoma).", CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5  ,11707110.0
-Sacubitril/Valsartan,AGTR1,inhibitor/antagonist,unclear,yes,yes,"Combination drug known as Entresto, used for heart failure treatment.",,
-Pitavastatin (Calcium),HMGCR,inhibitor/antagonist,unclear,yes,yes,"Approved for lowering cholesterol, part of statins class of drugs.", C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2],5282451.0
-Verteporfin,YAP1,inhibitor/antagonist,unclear,yes,yes,Used in photodynamic therapy for macular degeneration.,,
-Quinidine (15% dihydroquinidine),KCNH2,inhibitor/antagonist,unclear,yes,yes,Approved for arrhythmias as part of quinine alkaloids.,COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O  ,441074.0
-Canagliflozin (hemihydrate),SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for type 2 diabetes.,CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.O,24997615.0
-Osimertinib (mesylate),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for non-small cell lung cancer treatment.,CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O  ,78357807.0
-γ-Oryzanol,,inhibitor/antagonist,DNA methyltransferase inhibitor,no,yes,Used in supplements; limited human data.,C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/C6=CC(=C(C=C6)O)OC)C)C,5282164.0